MabCure, Inc. Files Provisional Patent in the U.S. for Ovarian Cancer Antibodies
03 Agosto 2010 - 8:00AM
Business Wire
Biotechnology company MabCure, Inc. (OTCBB: MBCI) today
announced the company has filed a provisional patent application
for its ovarian cancer diagnostic antibodies with the U.S. Patent
and Trademark Office. The filing was based on positive results of a
recent study that showed MabCure’s tumor-specific monoclonal
antibodies (MAbs) successfully identified ovarian cancer in blood
(94 percent) and distinguished it from benign tumors of the ovaries
or healthy blood obtained from men and women. The patent
application covers a panel of MAbs, each of which is capable of
diagnosing ovarian cancer, and several that can correctly
distinguish between ovarian cancer and benign tumors.
“Filing the patent on these important discoveries is a
significant step towards securing our intellectual property
position and moving forward with potential strategic relationships
and commercialization of what would be a highly specific serum
diagnostic test for ovarian cancer,” said Amnon Gonenne, Ph.D., CEO
of MabCure.
In a blinded study of 54 blood samples, MabCure’s MAbs correctly
diagnosed 16 of the 17 ovarian cancers with a diagnostic
sensitivity of 94 percent and 100 percent specificity. The samples
were comprised of 17 patients with ovarian cancer, 5 patients with
benign tumors of the ovaries, 24 healthy young females and 8
males.
“Beyond the value of our test to diagnose ovarian cancer in a
highly accurate manner and with no false positives, the potential
value of our proprietary MAbs is also in helping to identify
tumor-specific antigens or cancer-specific targets for the ultimate
treatment of ovarian cancer,” said Gonenne.
About Ovarian Cancer
Each year, 230,000 women worldwide are diagnosed with ovarian
cancer, or cancer that forms in the tissues of the ovary,
accounting for three percent of cancers in women. More than 125,000
women die from ovarian cancer annually, making it the fifth leading
cause of cancer death in women and the deadliest of all
gynecological cancers.
About MabCure’s Technology
MabCure has re-engineered classic hybridoma technology. Classic
hybridoma technology is based on the generation of immortal hybrid
cells or hybridoma, which follows the fusion of antibody-producing
B-cells with myeloma tumor cells. Each hybridoma continuously
manufactures a single monoclonal antibody. MabCure’s enhanced
technology has improved upon this process by increasing MAb yield,
improving production times exponentially, and enhancing
specificity.
MabCure has successfully generated hybridoma libraries for four
different cancers that produce, respectively, antibodies to
melanoma, to an aggressive form of prostate cancer, to ovarian
cancer, and to colon carcinomas. These antibodies have been shown
to be specific and "universal" to each cancer, respectively, (i.e.
they recognize every cancer from different individuals having that
particular disease and do not react with any normal antigen tested
so far). These MAbs are the first candidates for the development of
novel diagnostic tools, imaging agents and drugs to treat the
corresponding cancers.
About MabCure
MabCure is a U.S. biotechnology company whose mission is to
change the perception of cancer as being a largely incurable
disease. MabCure owns proprietary technology for the creation of
unique and highly specific monoclonal antibodies (MAbs), which the
company plans to develop as diagnostic tools, imaging agents and
therapeutic drugs to treat lethal cancers. The company’s initial
focus is on the development of novel diagnostic tests for the early
detection of ovarian, prostate, and colorectal cancers, each with
multi-billion dollar global market potential. MabCure is also
currently exploring the potential of its anti-melanoma antibodies
for the development of imaging and therapeutic agents. The company
is headquartered in Hasselt, Belgium. For more information about
MabCure and to sign up for e-mail updates, visit
www.mabcure.com.
This news release contains “forward-looking statements.”
Statements in this news release which are not purely historical are
forward-looking statements and include any statements regarding
beliefs, plans, expectations or intentions regarding the future.
Actual results could differ from those projected in any
forward-looking statements due to numerous factors. Such factors
include, among others, the change of business focus of the
management of the Company and the inability of the Company to
pursue its current objectives. These forward-looking statements are
made as of the date of this news release and the Company assumes no
obligation to update the forward-looking statements, or to update
the reasons why actual results could differ from those projected in
the forward-looking statements.
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