TIDMEVG

Evgen Pharma PLC

10 November 2021

Evgen Pharma plc

("Evgen" or the "Company")

Peer reviewed publication of data on SFX-01 in glioblastoma

Substantial pre-clinical data set generated by collaborators at the University of Aquila and other Italian centres.

Evgen Pharma plc (AIM: EVG), a clinical stage drug development company developing sulforaphane based medicines for the treatment of multiple diseases, notes the publication of data in preclinical models of glioblastoma (GBM) generated by Dr Claudio Festuccia and colleagues at the Universities of Aquila, Rome and Rieti, Italy (Colapietro et al, Pharmaceuticals, 2021, 14, 1082).

GBM, also known as glioblastoma multiforme, is an aggressive type of cancer (a type of malignant glioma) that can occur in the brain or spinal cord. GBM is very difficult to treat, and a cure is most often not possible; treatments generally slow progression of the cancer and reduce signs and symptoms. The average survival time is 12-18 months, with only 25% of glioblastoma patients surviving more than one year, and only 5% of patients surviving more than five years.

The in vitro data, in GBM cells and patient-derived glioma-initiating cells, show anti-tumour activity of the Company's lead asset SFX-01. The work goes on to show in vivo anti-tumour activity in both sub-cutaneous and orthotopic xenograft (tumour cell lines are implanted in the brain) models of GBM. In both models, SFX-01 reduced tumour growth substantially and demonstrated statistically significant improved survival. The in vitro work was complemented by a recent pre-print publication from a different laboratory, the University of Auckland, New Zealand, in patient derived cells and 3D spheroid models of GBM (Leung et al 2021).

Evgen recently announced the grant of Orphan Drug Designation in the USA for Malignant Glioma, affording the programme additional data protection and other incentives.

Dr Huw Jones, CEO of Evgen, commented: "We are very pleased to see the publication of this important work by Dr Festuccia and colleagues. The data generated underpin our decision to focus on glioblastoma as one of our core programmes. Our design work on a Phase 2 study in glioblastoma patients is well advanced and we are discussing the design with a number of prominent UK and European clinical centres. In due course we hope to contribute a new treatment option for patients with this devastating disease."

Enquiries:

 
  Evgen Pharma plc www.evgen.com                                          via Walbrook 
  Dr Huw Jones, CEO 
  Richard Moulson, CFO 
 
  finnCap www.finncap.com                                          +44 (0)20 7220 0500 
  Geoff Nash / Teddy Whiley (Corporate 
   Finance) 
  Alice Lane (ECM) 
 
  Walbrook PR                             +44 (0)20 7933 87870 or evgen@walbrookpr.com 
                                                    +44 (0)7876 741 001 / + 44 (0)7867 
  Anna Dunphy / Phillip Marriage                                               984 082 
 
 

About Evgen Pharma plc

Evgen Pharma is a clinical stage drug development company developing sulforaphane based medicines for the treatment of multiple diseases. The Company's core technology is Sulforadex(R), a method for synthesising and stabilising the naturally occurring compound sulforaphane and novel proprietary analogues based on sulforaphane. The lead product, SFX-01, is a patented composition of synthetic sulforaphane and alpha-cyclodextrin.

Clinical data from the Company's open-label Phase II STEM trial has shown that SFX-01 can halt the growth of progressing tumours in patients with oestrogen-positive (ER+) metastatic breast cancer, and in some cases significantly shrink the tumour, whilst causing very few side effects.

The has its headquarters at Alderley Park, Cheshire, and its registered office is at the Liverpool Science Park, Liverpool. It is listed on the AIM market of the London Stock Exchange and trades under the ticker symbol EVG.

For further information, please visit: www.evgen.com

For research on the Company, please visit: http://evgen.com/investors/analyst-coverage/

This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the London Stock Exchange. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

Reach is a non-regulatory news service. By using this service an issuer is confirming that the information contained within this announcement is of a non-regulatory nature. Reach announcements are identified with an orange label and the word "Reach" in the source column of the News Explorer pages of London Stock Exchange's website so that they are distinguished from the RNS UK regulatory service. Other vendors subscribing for Reach press releases may use a different method to distinguish Reach announcements from UK regulatory news.

RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy.

END

NRAUKVNRASUARAA

(END) Dow Jones Newswires

November 10, 2021 02:00 ET (07:00 GMT)

Evgen Pharma (LSE:EVG)
Gráfica de Acción Histórica
De Dic 2021 a Ene 2022 Haga Click aquí para más Gráficas Evgen Pharma.
Evgen Pharma (LSE:EVG)
Gráfica de Acción Histórica
De Ene 2021 a Ene 2022 Haga Click aquí para más Gráficas Evgen Pharma.