FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public
Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

MITRO THOMAS A
2. Issuer Name and Ticker or Trading Symbol

ISTA PHARMACEUTICALS INC [ ISTA ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
VP, Sales & Marketing
(Last)          (First)          (Middle)

50 TECHNOLOGY
3. Date of Earliest Transaction (MM/DD/YYYY)

5/22/2012
(Street)

IRVINE, CA 92618
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   5/22/2012     (1) M    30000   A $8.5000   145202   D    
Common Stock   5/22/2012     (1) F    28084   D $9.0800   117118   D    
Common Stock   5/22/2012     (1) M    1253   A $3.4900   118371   D    
Common Stock   5/22/2012     (1) F    482   D $9.0800   117889   D    
Common Stock   5/22/2012     (1) M    15334   A $6.7700   133223   D    
Common Stock   5/22/2012     (1) F    11433   D $9.0800   121790   D    
Common Stock   5/22/2012     (1) M    15729   A $7.4300   137519   D    
Common Stock   5/22/2012     (1) F    12871   D $9.0800   124648   D    
Common Stock   5/22/2012     (1) M    21780   A $4.4600   146428   D    
Common Stock   5/22/2012     (1) F    10698   D $9.0800   135730   D    
Common Stock   5/22/2012     (1) M    21731   A $1.0400   157461   D    
Common Stock   5/22/2012     (1) F    2489   D $9.0800   154972   D    
Common Stock   5/22/2012     (1) M    9862   A $3.6300   164834   D    
Common Stock   5/22/2012     (1) F    3943   D $9.0800   160891   D    
Common Stock   5/22/2012     (1) M    1115   A $6.8200   162006   D    
Common Stock   5/22/2012     (1) F    837   D $9.0800   161169   D    

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Incentive Stock Option (right to buy)   $1.0400   5/22/2012     (1) M         21731    3/3/2009   2/3/2019   Common Stock   21731   $9.0800   11504   D    
Incentive Stock Option (right to buy)   $3.4900   5/22/2012     (1) M         1253    1/16/2003   12/16/2012   Common Stock   1253   $9.0800   0   D    
Incentive Stock Option (right to buy)   $3.6300   5/22/2012     (1) M         9862    3/2/2010   2/2/2020   Common Stock   9862   $9.0800   26842   D    
Incentive Stock Option (right to buy)   $4.4600   5/22/2012     (1) M         21780    3/8/2008   2/8/2018   Common Stock   21780   $9.0800   0   D    
Incentive Stock Option (right to buy)   $6.7700   5/22/2012     (1) M         15334    3/16/2006   2/16/2016   Common Stock   15334   $9.0800   0   D    
Incentive Stock Option (right to buy)   $6.8200   5/22/2012     (1) M         1115    3/7/2011   2/7/2021   Common Stock   1115   $9.0000   22256   D    
Incentive Stock Option (right to buy)   $7.4300   5/22/2012     (1) M         15729    3/2/2007   2/2/2017   Common Stock   15729   $9.0800   0   D    
Incentive Stock Option (right to buy)   $8.5000   5/22/2012     (1) M         30000    7/1/2003   6/21/2012   Common Stock   30000   $9.0800   0   D    

Explanation of Responses:
( 1)  Mr. Mitro exercised options for 116,804 of Issuer's shares under his Employee Stock Option (as shown in Table II of this Form 4). Of that amount, Mr. Mitro elected to have the Issuer withhold 70,837 shares to cover the exercise price in connection with the exercise of his Employee Stock Option (as shown in Table II of the Form 4). Mr. Mitro continues to hold the net remaining amount of 45,967 shares.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
MITRO THOMAS A
50 TECHNOLOGY
IRVINE, CA 92618


VP, Sales & Marketing

Signatures
/s/ Brian G. Drazba Attorney-in-fact For: Thomas A. Mitro 5/22/2012
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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