Lorus Toxicology Program Supports Novel Route of Administration of the Anticancer Drug LOR-2040 in Bladder Cancer
05 Agosto 2008 - 7:00AM
Marketwired
TORONTO, ONTARIO (AMEX: LRP) ("Lorus"), a biopharmaceutical
company specializing in the research and development of
pharmaceutical products and technologies for the management of
cancer, today announced the successful completion of GLP toxicology
studies to explore a novel route of administration for its
clinical-stage anticancer drug, LOR-2040.
Two studies were conducted to assess toxicity of LOR-2040 when
administered by intravesical (direct) administration into the
bladder. In both studies, no evidence of toxicity was seen
following single or repeated doses of LOR-2040 given with this
method of administration. Toxicity was evaluated based on a wide
range of observations including detailed examination of urinary
tract tissues.
The intravesical toxicology studies are the first assessment of
local tissue toxicity of this drug. LOR-2040 has previously
demonstrated low toxicity when administered intravenously, which is
the current route of administration for this drug in clinical
trials.
Successful completion of these studies supports Lorus' plan to
submit an Investigational New Drug (IND) application for the use of
LOR-2040 in the treatment of bladder cancer during Q4, 2008.
"By completing this development program we have demonstrated
that LOR-2040 can be given safely with this new route of
administration", said Dr. Aiping Young, Lorus' President and CEO.
"The results of these studies provide further confirmation of the
high safety profile seen with LOR-2040 and of the potential utility
of this drug for the treatment of bladder cancer. I am pleased that
we are on schedule to advance LOR-2040 for the treatment of this
indication".
About LOR-2040
LOR-2040 (formerly GTI-2040) is an RNA-targeted drug that
specifically targets the R2 component of ribonucleotide reductase,
which is required for DNA synthesis and cell proliferation. Through
downregulation of R2, LOR-2040 has demonstrated strong antitumor
and antimetastatic activity in a variety of tumor types in both in
vivo and in vitro models and is under study in a multiple Phase
I/II clinical program, including an advanced Phase II clinical
trial with LOR-2040 and high dose Ara-C (HiDAC) in refractory and
relapsed Acute Myeloid Leukemia (AML). The R2 target has been
described as a malignant determinant that is elevated in a wide
range of tumors, and can cooperate with a variety of cellular
cancer causing genes known as oncogenes to enhance tumor growth and
metastatic potential.
About Lorus
Lorus is a biopharmaceutical company focused on the research and
development of novel therapeutics in cancer. Lorus' goal is to
capitalize on its research, preclinical, clinical and regulatory
expertise by developing new drug candidates that can be used,
either alone, or in combination with other drugs, to successfully
manage cancer. Through its own discovery efforts and an acquisition
and in-licensing program, Lorus is building a portfolio of
promising anticancer drugs. Lorus Therapeutics Inc. is listed on
the Toronto Stock Exchange under the symbol LOR, and on the
American Stock Exchange under the symbol LRP.
Forward Looking Statements
This press release may contain forward-looking statements within
the meaning of Canadian and U.S. securities laws. Such statements
include, but are not limited to, statements relating to: our
research program plans, our plans to conduct clinical trials, the
successful and timely completion of clinical studies and the
regulatory approval process, our ability to fund future research,
our plans to obtain partners to assist in the further development
of our product candidates, the establishment of corporate
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could cause our actual results, performance or achievements to be
materially different from any future results, performance, or
achievements that may be expressed or implied by such
forward-looking statements, including, among others: our ability to
obtain the capital required for research and operations, the
inherent risks in early stage drug development including
demonstrating efficacy, development time/cost and the regulatory
approval process; the progress of our clinical trials; our ability
to find and enter into agreements with potential partners; our
ability to attract and retain key personnel; changing market
conditions; and other risks detailed from time-to-time in our
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and annual filings with Canadian securities regulators and the
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Should one or more of these risks or uncertainties materialize,
or should the assumptions set out in the section entitled "Risk
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materially from those described herein. These forward-looking
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not intend, and do not assume any obligation, to update these
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and accordingly investors are cautioned not to put undue reliance
on forward-looking statements due to the inherent uncertainty
therein.
Lorus Therapeutics Inc.'s recent press releases are available
through the Company's website at www.lorusthera.com. For Lorus'
regulatory filings on SEDAR, please go to www.Sedar.com. For SEDAR
filings prior to July 10, 2007 you will find these under the
company profile for Global Summit Real Estate Inc. (Old Lorus).
Contacts: Lorus Therapeutics Inc. Dr. Saeid Babaei (416)
798-1200 ext. 490 Email: ir@lorusthera.com Website:
www.lorusthera.com
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