| FireStar Software, Inc. |  |  1.62% |  |    1.48% | 
+-------------------------+--+--------+--+----------+ 
| Kromek                  |  |  1.66% |  |    1.20% | 
+-------------------------+--+--------+--+----------+ 
| Motif BioSciences, Inc. |  |  3.81% |  |    3.91% | 
+-------------------------+--+--------+--+----------+ 
| Myconostica Limited     |  |  0.34% |  |    0.26% | 
+-------------------------+--+--------+--+----------+ 
| PrivateMarkets Inc.     |  |  3.01% |  |     -    | 
+-------------------------+--+--------+--+----------+ 
| WellGen, Inc.           |  |  4.59% |  |    4.57% | 
+-------------------------+--+--------+--+----------+ 
 
 
The Directors who held office at 31 December 2008 had the following interests in 
the Company's ordinary share capital: 
 
 
+--------------------+----------+-------------+-+---------------+ 
|                    |          |        2008 | |          2007 | 
+--------------------+----------+-------------+-+---------------+ 
|                    |          |    Ordinary | |      Ordinary | 
+--------------------+----------+-------------+-+---------------+ 
|                    |          |      Shares | |        Shares | 
+--------------------+----------+-------------+-+---------------+ 
|                    |          |             | |               | 
+--------------------+----------+-------------+-+---------------+ 
| Richard M.         |          |             | |   2,398,163   | 
| Mansell-Jones      |          | 2,693,774   | |               | 
+--------------------+----------+-------------+-+---------------+ 
| Richard C.E.       |          |             | |   20,734,155  | 
| Morgan             |          | 21,698,211  | |               | 
+--------------------+----------+-------------+-+---------------+ 
| Robert J. Bertoldi |          |             | |   5,643,237   | 
|                    |          | 5,674,844   | |               | 
+--------------------+----------+-------------+-+---------------+ 
| R. James Macaleer  |          |             | |   19,769,248  | 
|                    |          | 19,917,054  | |               | 
+--------------------+----------+-------------+-+---------------+ 
| Anthony W. Henfrey |          | 904,352     | |   858,861     | 
+--------------------+----------+-------------+-+---------------+ 
 
 
 
 
Aggregate Directors' remuneration 
 
 
The total amounts for Directors' remuneration was as follows: 
+------------+-----------+----------+----------+ 
|            |           |          |          | 
+------------+-----------+----------+----------+ 
|            |      Year |          |     Year | 
|            |     ended |          |    ended | 
+------------+-----------+----------+----------+ 
|            |        31 |          |       31 | 
|            |  December |          | December | 
|            |      2008 |          |     2007 | 
+------------+-----------+----------+----------+ 
|            |       US$ |          |      US$ | 
+------------+-----------+----------+----------+ 
|            |           |          |          | 
+------------+-----------+----------+----------+ 
| Emoluments | 1,093,775 |          |  988,163 | 
+------------+-----------+----------+----------+ 
 
 
 
 
 
24. Related party transactions, (continued) 
 
 
Directors' emoluments and compensation 
 
 
 
 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
|                        |      Group |          |    Group |          |    Group |          |      Year |          |     Year | 
|                        |            |          |          |          |          |          |     ended |          |    ended | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
|                        | Fees/Basic |          | Benefits |          |   Annual |          |        31 |          |       31 | 
|                        |            |          |       in |          |          |          |  December |          | December | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
|                        |     salary |          |     kind |          |  bonuses |          |      2008 |          |     2007 | 
|                        |            |          |          |          |          |          |     total |          |    total | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
|                        |        US$ |          |      US$ |          |      US$ |          |       US$ |          |      US$ | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Name of Director       |            |          |          |          |          |          |           |          |          | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Executive - salary     |            |          |          |          |          |          |           |          |          | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Richard C.E. Morgan    |    350,000 |          |   14,343 |          |  164,900 |          |   529,243 |          |  474,034 | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Robert J. Bertoldi     |    300,000 |          |   19,322 |          |   85,210 |          |   404,532 |          |  354,129 | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Non-executive - fees   |            |          |          |          |          |          |           |          |          | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Richard M.             |     70,000 |          |        - |          |        - |          |    70,000 |          |   70,000 | 
| Mansell-Jones          |            |          |          |          |          |          |           |          |          | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| R. James Macaleer      |     35,000 |          |        - |          |        - |          |    35,000 |          |   35,000 | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Anthony W. Henfrey     |     35,000 |          |        - |          |        - |          |    35,000 |          |   35,000 | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Ronald E. Thomas       |     20,000 |          |        - |          |        - |          |    20,000 |          |   20,000 | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
|                        |            |          |          |          |          |          |           |          |          | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
| Aggregate emoluments   |    810,000 |          |   33,665 |          |  250,110 |          | 1,093,775 |          |  988,163 | 
+------------------------+------------+----------+----------+----------+----------+----------+-----------+----------+----------+ 
 
 
 
 
The annual bonuses were issued in cash and shares of the Company. 
 
 
Directors' share options 
 
 
Aggregate emoluments disclosed above do not include any amounts for the value of 
options to acquire ordinary shares in the company granted to or held by the 
Directors. Details of options for Directors who served during the year are as 
follows: 
 
 
+-----------+-+---------------------+--------------------+--+-------------+--+---------+-+--------------+-+----------+-+-------------+-+--------------------+ 
|           | |                                          |  |             |  |         | |              | |          | |        Date | |                    | 
|           | |                                          |  |             |  |         | |              | |          | |        from | |                    | 
+-----------+-+------------------------------------------+--+-------------+--+---------+-+--------------+-+----------+-+-------------+-+--------------------+ 
|   Name of | |                                          |  |           1 |  |         | |           31 | | Exercise | |       which | |   Expiry           | 
|           | |                                          |  |     January |  |         | |     December | |          | |             | |                    | 
+-----------+-+------------------------------------------+--+-------------+--+---------+-+--------------+-+----------+-+-------------+-+--------------------+ 
|  Director |                       |             Scheme |  |        2008 |  | Granted | |         2008 | |    price | | exercisable | |   date             | 
+-----------+-----------------------+--------------------+--+-------------+--+---------+-+--------------+-+----------+-+-------------+-+--------------------+ 
|           | |                                          |  |             |  |         | |              | |          | |             | |                    | 
+-----------+-+------------------------------------------+--+-------------+--+---------+-+--------------+-+----------+-+-------------+-+--------------------+ 
| Richard   | | 2006 Unapproved Share Option Plan           |   2,000,000 |  |   -     | |   2,000,000  | |  GBP0.23 | | 1           | |  30 June 2021      | 

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