RNS Number:9123K
Amvescap PLC
09 May 2003

                                              FORM SAR 3


Lodge with Company Announcements Office and the Panel.  A copy must also be sent to the company the
shares of which are acquired.

                                                                          Date of disclosure 9 MAY 2003

                             DISCLOSURE UNDER RULE 3 OF THE RULES GOVERNING
                               SUBSTANTIAL ACQUISITIONS OF SHARES ("SARs")

Date of acquisition 8 MAY 2003

Acquisition in ........ PHYTOPHARM PLC ...... (name of company)


(1)     Class of voting shares          Number of shares/rights          If rights over shares
        (eg ordinary shares)            over shares acquired             acquired, as opposed
                                                                         to the shares
                                                                         themselves, specify
                                                                         nature of rights

        ORDINARY 1P                     70,000 shares                            -
             -                          N/A    rights                            -

(2)     Resultant total holding         Resultant total holding          Total percentage
        of voting shares (and %         of rights over shares
        of total voting shares          (and % of total voting
        in issue)                       shares in issue)

        8,520,434 (22.04%)                             -                 8,520,434 (22.04%)

(3)     Party making disclosure................ AMVESCAP PLC ..................


(4)     (a)   Name of person acquiring shares or rights over shares  DISCRETIONARY MANAGED CLIENTS OF AMVESCAP

              and, if different, beneficial owner ................................

        (b)   Names of any other persons acting by
              agreement or understanding (see SAR 5)............................


Signed, for and on behalf of the party named in (3) above........R CLYDE.....

(Also print name of signatory)............ROBERT CLYDE.......................

Telephone and extension number............020 7065 3720......................



Note. Under SAR 5, the holdings of and acquisitions by persons acting by
agreement or understanding must be aggregated and treated as a holding of or
acquisition by one person.  Note 3 on SAR 5 requires persons who must aggregate
holdings to disclose certain disposals.

For full details of the SARs disclosure requirements, see Rules 3 and 5 of the
SARs.  If in doubt, contact the Panel on Takeovers and Mergers, Monitoring
Section, Tel. No: 020 7638 0129. Email:monitoring@disclosure.org.uk


                      This information is provided by RNS
            The company news service from the London Stock Exchange
END

SADNKCKQDBKDFPK_SN_RNS9123K_SU_RNSTEST_XX_114929.9507_RZ__RT_R.xRoute.000
~