CYTO Altamira Therapeutics Ltd

Exhibit 99.2

 

MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

 

This management’s discussion and analysis is designed to provide you with a narrative explanation of our financial condition and results of operations. We recommend that you read this in conjunction with our Unaudited Condensed Consolidated Interim Financial Statements as of and for the six months ended June 30, 2022 and 2021 included as Exhibit 99.1 to this Report on Form 6-K, which have been prepared in accordance with International Accounting Standard (“IAS”) 34, Interim Financial Reporting. We also recommend that you read our management’s discussion and analysis and our audited consolidated financial statements and the notes thereto, which appear in our Annual Report on Form 20-F for the year ended December 31, 2021 (the “Annual Report”) filed with the U.S. Securities and Exchange Commission (the “SEC”) pursuant to the U.S. Securities and Exchange Act of 1934, as amended.

 

Unless otherwise indicated or the context otherwise requires, all references in this report to “Altamira Therapeutics Ltd.” or “Altamira,” the “Company,” “we,” “our,” “ours,” “us” or similar terms refer to (i) Auris Medical Holding Ltd. (formerly Auris Medical Holding AG), or Auris Medical (Switzerland), together with its subsidiaries, prior to our corporate reorganization by way of the Merger (as defined below) on March 13, 2018 (i.e. to the transferring entity), (ii) to Auris Medical Holding AG (formerly Auris Medical NewCo Holding AG), together with its subsidiaries after the Merger (i.e. to the surviving entity) and prior to the Redomestication (as defined below) and (iii) to Auris Medical Holding Ltd., a Bermuda company, or Auris Medical (Bermuda), the successor issuer to Auris Medical (Switzerland) under Rule 12g-3(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), after the effective time of the Redomestication, which occurred on March 18, 2019. The trademarks, trade names and service marks appearing in this report are property of their respective owners.

 

Altamira Therapeutics Ltd. is an exempted company incorporated under the laws of Bermuda. We began our operations as a corporation organized in accordance with Swiss law and domiciled in Switzerland under the name Auris Medical Holding AG (“Auris Medical (Switzerland)”). Following shareholder approval at an extraordinary general meeting of shareholders held on March 8, 2019 and upon the issuance of a certificate of continuance by the Registrar of Companies in Bermuda on March 18, 2019, we discontinued as a Swiss company and, pursuant to Article 163 of the Swiss Federal Act on Private International Law and pursuant to Section 132C of the Companies Act 1981 of Bermuda (the “Companies Act”), continued existence under the Companies Act as a Bermuda company with the name “Auris Medical Holding Ltd.” (the “Redomestication”). On March 18, 2019, the common shares of Auris Medical Holding Ltd. began trading on the Nasdaq Capital Market under the trading symbol “EARS”. Our registered office is located at Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda. On May 1, 2019, we effected a one-for-twenty reverse share split (the “2019 Reverse Share Split”) of our issued and outstanding common shares. Following shareholders’ approval at an extraordinary general meeting of shareholders held on July 21, 2021 we changed our name to Altamira Therapeutics Ltd. On October 25, 2022, the Company effected a one-for-twenty reverse share split (the “2022 Reverse Share Split”) of the Company’s issued and outstanding common shares. All per share amounts and numbers of common shares in this report reflect the 2019 Reverse Share Split and the 2022 Reverse Share Split.

 

Unless indicated or the context otherwise requires, (i) all references in this report to our common shares as of any date prior to March 13, 2018 refer to the common shares of Auris Medical (Switzerland) (having a par value of CHF 0.40 per share (pre-2019 Reverse Share Split and 2022 Reverse Share Split)) prior to the 10:1 “reverse share split” effected through the Merger, (ii) all references to the our common shares as of, and after, March 13, 2018 and prior to the Redomestication refer to the common shares of Auris Medical (Switzerland) (having a par value of CHF 0.02 per share (pre-2019 Reverse Share Split and 2022 Reverse Share Split)) after the 10:1 “reverse share split” effected through the Merger (iii) all references to our common shares as of, and after, the Redomestication on March 18, 2019 refer to the common shares of the Company (having a par value of CHF 0.02 per share pre-2019 Reverse Share Split and 2022 Reverse Share Split)), (iv) the Company’s common shares after May 1, 2019, the date of the 2019 Reverse Share Split have a par value of CHF 0.40 each (pre-2022 Reverse Share Split) and (v) the Company’s common shares after October 25, 2022, the date of the 2022 Reverse Share Split have a par value of CHF 0.20 each. As of June 30, 2020, we reduced the par value of our shares to CHF 0.01 each (pre-2022 Reverse Share Split).

 

We prepare and report our consolidated financial statements and financial information in accordance with International Financial Reporting Standards (“IFRS”) as issued by the International Accounting Standards Board (the “IASB”). None of our financial statements were prepared in accordance with generally accepted accounting principles in the United States (“U.S. GAAP”). We maintain our books and records in Swiss Francs. We have made rounding adjustments to some of the figures included in this management’s discussion and analysis. Accordingly, numerical figures shown as totals in some tables may not be an arithmetic aggregation of the figures that precede them. Unless otherwise indicated, all references to currency amounts in this discussion and analysis are in Swiss Francs.

 

This discussion and analysis is dated as of November 28, 2022.

 

Overview

 

We are a clinical-and commercial-stage biopharmaceutical company developing therapeutics that address important unmet medical needs. We are currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore™ / SemaPhore™ platforms; preclinical), nasal sprays for protection against airborne allergens, and where approved, viruses (Bentrio™; commercial) or the treatment of vertigo (AM-125; Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen^® and Sonsuvi^®, Phase 3). We have announced our intention to reposition the Company around RNA therapeutics while exploring strategic options to either divest our traditional businesses or spin them off as a separate entity to shareholders.

 

 

Recent Developments

 

Development and commercial launch of Bentrio™ nasal spray

 

In June 2021 we announced the market launch of Bentrio™, our drug-free nasal spray for protection against airborne viruses and allergens, in Germany, and our intention to expand market coverage progressively through additional distribution channels and in further countries. Bentrio™ is marketed as an “over-the-counter” medical device. Bentrio™ is based on a gel emulsion which works by forming a protective layer on the nasal mucosa that acts as a physical barrier. In its natural state, Bentrio™ is viscous; for application via spray it must be briefly shaken, rendering it liquid. Upon contacting the nasal mucosa, the formulation reverts to its normal viscous state, which supports an extended nasal residence time. Development of the product had been initiated under code name AM-301 in summer 2020. For the project, we set up a new subsidiary, Altamira Medica Ltd. (“Altamira”), based in Zug, Switzerland.

 

On March 4, 2022 we announced that we had entered into an exclusive licensing and distribution agreement for Bentrio™ with Nuance Pharma Ltd. (“Nuance”) in Chinese Mainland, Hong Kong, Macau and South Korea (the “Territory”). Under the terms of the agreement, we will initially supply Bentrio™ to Nuance. Nuance made an upfront payment of USD 1 million and may pay to Altamira development and commercial milestones of up to USD 3 million and up to USD 19.5 million, respectively. In a second stage, Nuance will assume local production of the product for the Territory upon certain milestones. Once Nuance assumes local production of Bentrio™, it will pay to us a staggered royalty on net sales in the Territory at a high-single to low-double-digit percentage.

 

On May 20, 2022 we announced the results from a clinical trial with Bentrio™ in house dust mite (HDM) allergic rhinitis. The trial enrolled a total of 37 patients with a history of perennial allergic rhinitis (“PAR”) caused by HDM exposure. Study participants were randomized under an open label, three-period crossover design to receive either Bentrio™ in a single or double dose, or no treatment, prior to controlled allergen exposure in an environmental exposure chamber for three hours. Bentrio™ treatment reduced the increase in mean total nasal symptoms score (TNSS) by 1.1 points (-1.87 to -0.28 in the 95% confidence interval; p<0.01) vs. no treatment. The protective effect was observed both with a single or double puff per nostril with no meaningful difference between the two treatment approaches. Bentrio™ treatment was safe and well tolerated.

 

On June 25, 2022 we received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market Bentrio™ (“Bentrio Allergy Blocker”) for the treatment of allergic rhinitis (hay fever) in the US. Clearance was obtained for the following indication for use:

 

●

Bentrio is intended to treat hay fever and allergy sufferers by promoting alleviation of mild allergic symptoms (i.e. mild nasal irritation including itchy, runny, or congested nasal passages) triggered by the inhalation of various airborne allergens including indoor and outdoor environmental pollens, house dust, animal hair and dust mites.

 

●

Application of Bentrio produces a mucous-like gel barrier that coats the nasal membranes, traps inhaled allergens within the nasal cavity and helps with their clearance.

 

We intend to market and distribute Bentrio™ Allergy Blocker in the US, and going forward also in Europe, through well-established OTC consumer health companies.

 

AM-125 Phase 2 trial in acute vertigo (“TRAVERS”)

 

On June 13. 2022 we announced positive top-line data from our Phase 2 TRAVERS trial with AM-125 (intranasal betahistine) in acute vertigo. The randomized, double-blind, placebo-controlled TRAVERS trial enrolled at more than ten study sites across Europe a total of 124 patients who suffered from acute vertigo following surgery for the removal of a tumor. Patients were randomized to receive either AM-125 at up to 20 mg or a placebo three times daily for four weeks, which was followed by a two-week treatment-free observation period. In addition, all trial participants followed a standardized course of vestibular rehabilitation therapy. Improvement in the “Tandem Romberg” test, which measures how long patients are able to maintain balance with their two feet aligned one after the other while they have their eyes closed, served as the primary efficacy outcome. For reference, the trial also included 16 patients who received ‘open label’ oral betahistine at 16 mg three times daily (the approved dose in most countries worldwide).

 

The TRAVERS trial demonstrated good safety and tolerability of AM-125. Further, administration of AM-125 resulted in a dose- and time-dependent improvement in balance and vestibular compensation. At treatment period end, mean Tandem Romberg improvement was 10.9 sec. for the 20 mg group vs. 7.4 sec. for the placebo group (mixed model repeated measures, p=0.08, significant at α = 0.05, one-sided). This was corroborated by higher frequency of complete spontaneous nystagmus resolution (34.5 vs. 20.0% of patients). Based on the outcomes, we are planning to file an investigational new drug application with the US Food and Drug Administration (FDA) in the fourth quarter of 2022.

 

Acquisition of Trasir Therapeutics and strategic repositioning around RNA therapeutics

 

On June 1, 2021, we acquired 100% of the share capital of privately held Trasir Therapeutics Inc. (“Trasir”) through the merger of our subsidiary Auris Medical Inc. with and into Trasir (the “Merger”), with Trasir surviving the merger as the surviving entity. Trasir was subsequently renamed Altamira Therapeutics, Inc. and redomiciled in Dover, Delaware. Founded in 2014, Trasir has been a pioneer in the development of nanoparticles for extrahepatic oligonucleotide delivery.

 

The transaction has been the starting point for a strategic repositioning under which the Company intends to focus on the development of RNA therapeutics while in the medium term aiming to spin off or divest our non-RNA assets, which are our assets in neurotology, rhinology and allergology, including Bentrio™, AM-125, Keyzilen®, Sonsuvi® and certain early-stage drug product candidates. Dr. Samuel Wickline, Trasir’s founder and Professor of Medicine, was appointed Chief Scientific Officer and joined the Company’s leadership team. In addition, to reflect the Company’s strategic repositioning, the shareholders convened for a Special General Meeting on July 21, 2021 to approve the change of its corporate name to Altamira Therapeutics Ltd. and elected Margrit Schwarz, PhD, MBA, as an additional Board member. Further, on July 26, 2021, the Company’s common shares started trading under the ticker symbol “CYTO” instead of “EARS”.

 

 

Trasir’s core technology is the proprietary peptide polyplex platform OligoPhore™ and its equivalent SemaPhore™ that can engage any type of short interfering RNA (siRNA) or messenger RNA (mRNA), respectively, in rapid self-assembly. The technology allows for safe and effective systemic delivery of RNA payloads with efficient cellular uptake and full endosomal release. Importantly, it enables delivery to target tissues outside the liver, creating the potential for developing RNA-based therapies for a range of indications with substantial unmet need.

 

In various murine models of disease, OligoPhore™ and SemaPhore™ have been shown to protect the RNA payload (siRNA and/or mRNA) from degradation in the circulation, while enabling pH-dependent nucleotide endosomal escape and cytoplasmic delivery. Proof-of-concept for efficient delivery and target knockdown has been demonstrated for targets in the NF-kB family, various members of the ETS transcription factor family, and targets in the JNK and TAM pathways, enabling a preclinical development pathway for several oncology indications, rare diseases, as well as rheumatoid and osteoarthritis and inflammatory pathologies such as atherosclerosis.

 

In July 2021, we announced the selection of mutant KRAS-driven colorectal cancer as the first therapeutic indication for our OligoPhore™ oligonucleotide delivery platform and the launch of a development program under product development code AM-401. In July 2022 we announced the initiation of a second development program, AM-411, which is intended for the treatment of rheumatoid arthritis.

 

Russian invasion of Ukraine

 

In the context of Russia’s recent invasion of the Ukraine, oil and gas prices, which are key input factors for plastic parts such as those used for the primary packaging of Bentrio™, as well as other components such as cardboard for packaging have increased significantly and shown high volatility. Continued escalation of political tensions, economic instability, military activity or civil hostilities in Ukraine could result in significant price increases for such components or difficulties of our component suppliers to supply such components on a timely basis. If we are unable to pass on such price increases, or if component supplies are interrupted, our business, financial condition and results of operation could be adversely affected.

 

COVID-19 Pandemic

 

In December 2019, a novel strain of coronavirus COVID-19 was reported to have surfaced in Wuhan, China. The extent to which COVID-19 may impact our preclinical and clinical trial operations will depend on future developments, which are highly uncertain and cannot be predicted with confidence, such as the duration and geographic reach of the outbreak, the severity of COVID-19, and the effectiveness of actions to contain and treat COVID-19. For example, the COVID-19 outbreak delayed enrollment of patients into our “TRAVERS” phase 2 trial with AM-125. Candidates for participation in this trial undergo certain types of neurosurgery, which are classified as elective procedures. Due to the COVID-19 outbreak, many sites participating in the “TRAVERS” trial postponed elective procedures and temporarily reduced or suspended clinical research activities. The effect was particularly felt in spring 2020 and then again in early 2021.

 

The continued spread of COVID-19 globally could otherwise adversely impact our clinical trial operations, including our ability to recruit and retain patients and principal investigators and site staff who, as healthcare providers, may have heightened exposure to COVID-19 if an outbreak occurs in their geography. Disruptions or restrictions on our ability to travel to monitor data from our clinical trials, or to conduct clinical trials, or the ability of patients enrolled in our studies to travel, or the ability of staff at study sites to travel, as well as temporary closures of our facilities or the facilities of our clinical trials partners and their contract manufacturers, would negatively impact our clinical trial activities. In addition, we rely on independent clinical investigators, contract research organizations and other third-party service providers to assist us in managing, monitoring and otherwise carrying out our preclinical studies and clinical trials, including the collection of data from our clinical trials, and the outbreak may affect their ability to devote sufficient time and resources to our programs or to travel to sites to perform work for us. Similarly, our preclinical trials could be delayed and/or disrupted by the outbreak. As a result, the expected timeline for data readouts of our preclinical studies and clinical trials and certain regulatory filings may be negatively impacted, which would adversely affect our ability to obtain regulatory approval for and to commercialize our product candidates, increase our operating expenses and have a material adverse effect on our financial results. Finally, the COVID-19 outbreak and its impact on the global financial markets may limit our ability to raise additional funds to continuously fund our operations and complete the research and development of all our product candidates.

 

2022 Reverse Share Split

 

On October 25, 2022, we effected a reverse share split (the “2022 Reverse Share Split”) of our common shares at a ratio of one-for-twenty. When the reverse share split became effective, every 20 of our pre-split issued and outstanding common shares, par value 0.01 per share, were combined into one common share, par value CHF 0.20 per share. Effecting the 2022 Reverse Share Split reduced the number of our issued and outstanding common shares from 21,494,261 common shares to 1,074,713 common shares. It also simultaneously adjusted outstanding options issued under our equity incentive plan and outstanding warrants to purchase common shares. All per share amounts and numbers of common shares in this management’s discussion and analysis reflect the 2022 Reverse Share Split.

 

 

Collaboration and License Agreements

 

On December 11, 2020, Trasir entered into an Exclusive License Agreement with Washington University located in St. Louis, Missouri (“WU”), which Exclusive License Agreement was subsequently amended and restated in June 2021 (as so amended and restated, the “Agreement”), with effect as of December 11, 2020. Pursuant to the Agreement, WU granted Trasir an exclusive, worldwide, royalty-bearing license (with the right to sublicense) during the term of the Agreement under certain patent rights owned or controlled by WU to research, develop, make, have made, sell, offer for sale, use and import pharmaceutical products covered under such patent rights for all fields of use. Such licensed products may include “silencing RNA” (siRNAs) pharmaceutical preparations formulated in combination with Trasir’s proprietary delivery technologies. In consideration for such worldwide, exclusive license, the Company (through its acquisition of Trasir, described above) will be obligated to pay WU: annual license maintenance fees in the low five figures through first commercial sale; pre-clinical and clinical regulatory milestones; sales milestones; and a low single digit royalty based on annual net sales of licensed products worldwide for at least the applicable patent term or period of marketing exclusivity, whichever is longer, but in no case less than a minimum royalty term of 12 years; and a percentage share (in the double digits) of sublicensing revenues received by the Company in connection with licensed products. Such regulatory and sales milestones may total up to an aggregate of USD 4,375,000. In the event the Company fails to meet certain regulatory diligence milestones, WU will have the right to terminate the license. The Agreement also contains customary representations, warranties and covenants by both parties, as well as customary provisions relating to indemnification, confidentiality and other matters.

 

Research and Development Expense

 

Our research and development expense is highly dependent on the development phases of our research projects and therefore may fluctuate substantially from period to period. Our research and development expense mainly relates to the following key programs:

 

●

AM-301 for protection against airborne viruses and allergens. Since the initiation of the development program in September 2020, we have conducted a variety of in vitro and in vivo studies as well as clinical investigations to determine the tolerability, safety and efficacy of Bentrio™ and to meet various regulatory requirements for marketing the nasal spray as a medical device in various countries and regions. . While these assessments for obtaining market clearance and related expenditures were essentially completed in the third quarter of 2022, we have various other studies either ongoing or planned to further expand the body of evidence for current or additional uses of the product.

 

●

AM-401 for the treatment of mutant KRAS-driven colorectal cancer. Since the acquisition of Trasir became effective only on June 1, 2021, we have initiated additional pharmacology studies and the development and scale-up of the peptide carrier and siRNA payloads as well as analytical development. Expenditure levels are expected to increase further as we plan to conduct various IND-enabling studies, including toxicology in non-human primates, and move into larger-scale production of the peptide, siRNA payloads and nanoparticles.

 

●

AM-411 for the treatment of rheumatoid arthritis. We initiated in July 2022 a second development program based on our OligoPhore™ delivery platform, using siRNA targeting NF-kB (p65) for the treatment of rheumatoid arthritis. The program will benefit from substantial synergies with program AM-401.

 

●

AM-125 for the treatment of acute vestibular syndrome. We evaluated intranasal betahistine for the treatment of acute vestibular syndrome in the Phase 2 TRAVERS clinical trial. In June 2022 we reported positive results from the TRAVERS trial, which showed a time- and dose-dependent improvement in balance and vestibular compensation. In parallel, we have been conducting several IND-enabling preclinical studies which we completed during the second half of 2021 and the first half of 2022. We intend to file an IND with the FDA in the fourth quarter of 2022 and subsequently to initiate a Phase 3 clinical program.

 

●

AM-201 for Antipsychotic-Induced Weight Gain. We evaluated intranasal betahistine in a Phase 1b clinical trial in the prevention of antipsychotic-induced weight gain and somnolence. The study was initiated in March 2019 at a single site in Europe and completed in 2020. While the trial showed a dose dependent reduction in antipsychotic-induced weight gain, in the context of our strategic repositioning, we have decided to deprioritize project AM-201 and suspended all development work.

 

Other research and development expenses mainly relate to our pre-clinical studies of AM-102 (second generation tinnitus treatment). The expenses mainly consist of costs for synthesis of the pre-clinical compounds and costs paid to academic and other research institutions in conjunction with pre-clinical testing.

 

For a discussion of our other key financial statement line items, please see “Item 5—Operating and Financial Review and Prospects–Operating results — Financial Operations Overview” in the Annual Report.

 

 

Results of Operations

 

The numbers below have been derived from our Unaudited Condensed Consolidated Interim Financial Statements as of and for the six months ended June 30, 2022 and 2021. The discussion below should be read along with this financial information, and it is qualified in its entirety by reference to them.

 

Adjustment of June 30, 2022 Revenue

 

In the Company's Unaudited Condensed Consolidated Interim Financial Statements as of June 30, 2022 and for the six months ended June 30, 2022, furnished with the SEC on November 30, 2022 with a Report of Foreign Private Issuer on Form 6-K (the “Original Form 6-K”),, an upfront payment of $1 million (CHF 0.9 million) related to the exclusive licensing and distribution agreement with Nuance Pharma for Bentrio® was incorrectly recorded as revenue. In the audited financial statements as of December 31, 2022 included in the Company’s Annual Report on Form 20-F filed with the SEC on May 16, 2023, the upfront payment was recorded as deferred income, following the correction of the identified misstatement. Adjustments for this correction are reflected in the restated condensed consolidated interim financial statements as of June 30, 2022 and for the six months ended June 30, 2022 included in this report. The table below reflects the impact of the adjustments on key income statement and balance sheet line items.

 

Six months ended June 30, 2022

 

Adjusted consolidated Balance Sheet

 

		As of June 30, 2022
		As reported				Adjustment				Adjusted
Deferred income			-				932,200				932,200
Total non-current liabilities			1,014,188				932,200				1,946,388
Total liabilities			10,804,712				932,200				11,736,912
Accumulated deficit			(182,602,921	)			(932,200	)			(183,535,121	)
Total shareholders’ equity attributable to owners of the company			7,675,164				(932,200	)			6,742,964

 

Adjusted consolidated Statement of Profit or Loss and Other Comprehensive Loss

 

		Half-Year ended June 30, 2022
		As reported				Adjustment				Adjusted
Revenue			1,222,998				(932,200	)			290,798
Gross profit			30,766				(932,200	)			(901,434	)
Operating loss			(7,483,561	)			(932,200	)			(8,415,761	)
Loss before tax			(7,352,403	)			(932,200	)			(8,284,603	)
Net loss attributable of owners of the Company			(7,306,318	)			(932,200	)			(8,238,518	)
Total comprehensive loss attributable to owners of the Company			(7,160,269	)			(932,200	)			(8,092,469	)
Basic and diluted loss per share			(9.43	)			(1.20	)			(10.63	)

 

 

Comparison of the six months ended June 30, 2022 and 2021:          

 

		Six months ended
		June 30,
		2022
		(restated)				2021				Change
		(in thousands of CHF)								%
Revenue			291				-				n/a
Cost of sales			(1,192	)			-				n/a
Gross profit			(901	)			-				n/a
Other operating income			256				-				n/a
Research and development			(3,564	)			(3,394	)			5	%
Sales and marketing			(2,130	)			-				n/a
General and administrative			(2,076	)			(3,062	)			(32	)%
Operating loss			(8,415	)			(6,456	)			30	%
Interest expense			(377	)			(172	)			119	%
Foreign currency exchange gain (loss), net			58				292				(80	)%
Revaluation (loss)/gain from derivative financial instruments			451				(429	)			(205	)%
Transaction costs			(1	)			-				n/a
Loss before tax			(8,284	)			(6,765	)			22	%
Income tax gain			46				10				360	%
Net loss attributable to owners of the Company			(8,238	)			(6,755	)			22	%
Other comprehensive income:
Items that will never be reclassified to profit or loss
Remeasurements of defined benefit liability			210				449				(53	)%
Items that are or may be reclassified to profit and loss
Foreign currency translation differences			(64	)			(42	)			52	%
Other comprehensive loss			146				407				(64	)%
Total comprehensive loss attributable to owners of the company			(8,092	)			(6,348	)			27	%

 

Revenue

 

The revenue for the first half-year of 2022 includes product sales of Bentrio™.

 

Cost of Sales                  

 

		Six months ended
		June 30,
		2022				2021				Change
		(in thousands of CHF)								%
Product purchases, packaging and logistics			(348	)			-				n/a
Employee benefits and expenses			(79	)			-				n/a
Inventory write-down			(765	)			-				n/a
Total			(1,192	)			-				n/a

 

As of June 30, 2022, the Company’s inventory consisted of the product Bentrio, a drug-free nasal spray for protection against airborne viruses and allergens. Bentrio has a limited shelf life, which may affect the salability of the product, and is packaged in various configurations (stock keeping units, “SKUs”) for different markets and in different languages to address specific requirements under national rules and regulations or by trade channels. Based on a management review of the inventory as at June 30, 2022 for any obsolete or slow-moving items, the Company wrote down finished good inventories in the amount of CHF 0.8 million. The amount of the write down was expensed to the income statement under Cost of Sales.

 

 

Research and development expense                

 

		Six months ended
		June 30,
		2022				2021				Change
		(in thousands of CHF)								%
Clinical projects			(1,375	)			(1,181	)			16	%
Pre-clinical projects			(274	)			(231	)			19	%
Drug manufacturing and substance			(348	)			(765	)			(55	)%
Employee benefits			(1,324	)			(743	)			78	%
Other research and development expenses			(243	)			(474	)			(49	)%
Total			(3,564	)			(3,394	)			5	%

 

Research and development expenses amounted to CHF 3.6 million in the six months ended June 30, 2022. This represents an increase of CHF 0.2 million compared to the six months ended June 30, 2021. Research and development expenses reflected the following:

 

●

Capitalization of internal costs for AM-125. In the six months ended June 30, 2022, we capitalized direct costs related to our AM-125 program for a total amount of CHF 1.5 million compared to CHF 1.7 million for the six months ended June 30, 2021.

 

●

Clinical projects. In the six months ended June 30, 2022 clinical expenses were higher than in the six months ended June 30, 2021 by CHF 0.2 million due to higher trial activity levels.

 

●

Pre-clinical projects. In the six months ended June 30, 2022, pre-clinical expenses were essentially unchanged compared to the six months ended June 30, 2021.

 

●

Drug manufacture and substance. In the six months ended June 30, 2022, drug manufacture and substance related costs decreased by CHF 0.4 million compared to the six months ended June 30, 2021 due to lower levels of project work related to our AM-301 program.

 

●

Employee benefits. Employee expenses increased by CHF 0.6 million in the six months ended June 30, 2022 compared to the same period in 2021 due to a higher headcount and recruiting costs.

 

●

Other research and development expenses. Other research and development expenses decreased by CHF 0.2 million in the six months ended June 30, 2022 compared to the same period in 2021 as we incurred lower expenditures for intellectual property and regulatory consulting services to our AM-301 program.

 

Sales and marketing expense                

 

		Six months ended
		June 30,
		2022				2021				Change
		(in thousands of CHF)								%
Marketing and sales expenses			(2,028	)			-				n/a
Employee benefits and expenses			(102	)			-				n/a
Total			(2,130	)			-				n/a

 

Marketing and sales expenses are related to the commercial launch of Bentrio™ in selected European countries.

 

General and administrative expense                  

 

		Six months ended
		June 30,
		2022				2021				Change
		(in thousands of CHF)								%
Employee benefits			(405	)			(1,362	)			(70	)%
Lease expenses			(7	)			(26	)			(73	)%
Business development			(7	)			(521	)			(99	)%
Travel and representation			(33	)			(45	)			(27	)%
Administration costs			(1,565	)			(1,108	)			41	%
Depreciation Right-of-use assets			(59	)			-				n/a
Total			(2,076	)			(3,062	)			(32	)%

 

 

General and administrative expense decreased to CHF 2.1 million in the six months ended June 30, 2022 compared to CHF 3.1 million in the same period in the previous year, primarily due to lower employee benefits as there were lower shared-based bonus payments, which was partly offset by an increase in general administration costs.

 

Interest expense

 

Interest expense in the six months ended June 30, 2022 amounted to CHF 376,848 (June 30, 2021: CHF 172,462) included CHF 357,930 related to the FiveT convertible loan, as well as interest related to lease liabilities and bank charges.

 

Foreign currency exchange gain / (loss), net

 

For the six months ended June 30, 2022, fluctuations in foreign currency exchange rates resulted in a gain of CHF 0.06 million, compared to a gain of CHF 0.3 million during the same period in the previous year.

 

Revaluation gain / (loss) from derivative financial instruments

 

For the six months ended June 30, 2022, CHF 449,614 of the revaluation gain from derivative financial instruments is related to the revaluation of the financial derivatives embedded in the FiveT convertible loan. In the six months ended June 30, 2021, there was a revaluation loss from derivative financial instruments of CHF 428,742.

 

On January 30, 2018 we issued 1,875 warrants in connection with a direct offering of 3,125common shares, each warrant entitling its holder to purchase one common share at an exercise price of USD 2,000.00 per common share. As of March 13, 2018, following the consummation of the Merger, the warrants became exercisable for an aggregate of 1,875 of our common shares (assuming we decide to round up fractional common shares to the next whole common share), at an exercise price of USD 2,000.00 per common share. As of June 30, 2022 the fair value of the warrants amounted CHF 0. The revaluation gain of the derivative for the six months ended June 30, 2022 amounted to CHF 1,233, compared to a revaluation loss of CHF 12,740 in the same period in 2021.

 

On May 15, 2019, we issued 86,064 pre-funded warrants and 108,064 warrants in connection with the May 2019 Registered Offering of 22,000 common shares, with each pre-funded warrant entitling its holder to purchase one common share at an exercise price of CHF 0.20 and each warrant entitling its holder to purchase one common share at an exercise price of CHF 86.80. All warrants were exercised between December 2020 and March 2021.

 

Cash flows

 

Comparison of the six months ended June 30, 2022 and 2021      

 

The table below summarizes our cash flows for the six months ended June 30, 2022 and 2021:

 

		Six months ended
		June 30,
		2022				2021
		(in thousands of CHF)
Net cash used in operating activities			(5,584	)			(4,919	)
Net cash used in investing activities			(1,533	)			(1,989	)
Net cash from financing activities			6,542				3,845
Net effect of currency translation on cash			(36	)			271
Cash and cash equivalents at beginning of the period			984				11,259
Cash and cash equivalents at end of the period			373				8,467

 

Cash and funding sources

 

On February 4, 2022, the Company entered into a convertible loan agreement with FiveT Investment Management Ltd. The cash inflow from financing activities for the six months ended June 30, 2022, includes CHF 5.0 million from the Five T convertible loan as well as proceeds from equity issues.

 

 

On December 1, 2020, a tranche of the convertible loan provided by FiveT in the amount of CHF 895,455 was converted into 36,850 common shares at a conversion price of USD 27.00. The remaining amount of CHF 604,545 plus accumulated interest was converted into 25,841 common shares at a conversion price of USD 27.00 on March 4, 2021.

 

On December 3, 2020, the Company entered into securities purchase agreements with several institutional investors for the purchase and sale of 100,000 common shares at an offering price of USD 80.00 per share, pursuant to a registered direct offering. The net proceeds of the offering were approximately USD 7.3 million.

 

On May 15, 2019, the Company completed a public offering of (i) 22,000 common shares, together with warrants to purchase 22,000 common shares, and (ii) 86,064 pre-funded warrants, with each pre-funded warrant exercisable for one common share, together with warrants to purchase 86,064 common shares, including 5,500 common shares and warrants to purchase 5,500 common shares sold pursuant to a partial exercise by the underwriters of the underwriters’ over-allotment option (the “May 2019 Registered Offering”). The exercise price for the pre-funded warrants is CHF 0.20 per common share and for the warrants is CHF 86.80. The net proceeds to us from the May 2019 Registered Offering were approximately USD 7.6 million, after deducting underwriting discounts and other offering expenses payable by us. In December 2020, 63,192 warrants were exercised, leaving 44,872 warrants outstanding as of December 31, 2020. These remaining warrants were exercised in March 2021.

 

On November 30, 2018, the Company entered into a sales agreement, as amended (the “A.G.P. Sales Agreement”) with A.G.P./Alliance Global Partners (“A.G.P.”). Pursuant to the terms of the A.G.P. Sales Agreement, the Company may offer and sell its common shares, from time to time through A.G.P. by any method deemed to be an “at-the-market” offering as defined in Rule 415(a)(4) promulgated under the Securities Act. Pursuant to the A.G.P. Sales Agreement, the Company may sell common shares up to a maximum aggregate offering price of USD 25.0 million. As of June 30, 2022, the Company has sold 147,166 of its common shares for an aggregate offering price of USD 6.7 million pursuant to the A.G.P. Sales Agreement, and as of the date of this report, the Company has sold a total of 228,666 common shares for an aggregate offering price of USD 7.8 million pursuant to the A.G.P. Sales Agreement.

 

On July 17, 2018 the Company completed a public offering of 44,872 common shares, Series A warrants each entitling its holder to purchase 0.35 of a common share for an aggregate of 15,705 common shares, and Series B warrants entitling its holder to purchase 0.25 of a common share for an aggregate of 11,218 common shares (the “July 2018 Registered Offering”). The exercise price for both series Warrants at the time of the July 2018 Registered Offering was CHF 156.00 per common share. In accordance with the terms of certain Series B warrants, the exercise price for certain Series B warrants was reduced in two steps to ultimately CHF 29.40. The net proceeds to us from the July 2018 Registered Offering were approximately CHF 6.2 million, after deducting underwriting discounts and other offering expenses payable by us.

 

On April 23, 2020, the Company entered into a purchase agreement and a Registration Rights Agreement with Lincoln Park Capital Fund, LLC (the “2020 Commitment Purchase Agreement”). Pursuant to the purchase agreement, LPC agreed to subscribe for up to USD 10,000,000 of our common shares over the 30-month term of the purchase agreement. Through June 30, 2022, we issued a total of 165,000 of our common shares to LPC for an aggregate amount of USD 2,806,605 under the 2020 Commitment Purchase Agreement. During the six months ended June 30, 2022, we issued 105,000 of our common shares to LPC for an aggregate amount of USD 1,698,450 under the 2020 Commitment Purchase Agreement, and as of the date of this report, we have issued a total of 325,000 of our common shares to LPC for an aggregate amount of USD 4,003,820 under the 2020 Commitment Purchase Agreement.

 

On January 30, 2018, the Company completed a public offering of 3,125 common shares and concurrent offering of 1,875 warrants, each warrant entitling its holder to purchase one common share (the “January 2018 Registered Offering”). The net proceeds to the Company from the January 2018 Registered Offering were approximately CHF 4.5 million, after deducting placement agent fees and other estimated offering expenses payable by the Company. As of March 13, 2018, following the consummation of the Merger, the outstanding warrants issued in the January 2018 Registered Offering were exercisable for up to 1,875 common shares (assuming the Company rounds up fractional common shares to the next whole common share) at an exercise price of USD 2000.00 per common share.

 

Due to the COVID pandemic, Swiss banks granted special COVID-19 loans under certain conditions with a guarantee by the Swiss Government. Our Company was eligible for a loan of CHF 50,000, which was granted on March 26^th, 2020. The loan is interest-free and may be repaid at any time with a maximum term of five years. We repaid the loan on June 16, 2021.

 

We have no other ongoing material financial commitments, such as lines of credit or guarantees that are expected to affect our liquidity over the next five years, other than leases.

 

 

Funding requirements

 

We have incurred recurring losses and negative cash flows from operations since inception and we expect to generate losses from operations for the foreseeable future primarily due to research and development costs for our potential product candidates. We expect our total cash need for funding operations in 2022 to be in the range of CHF 12.0 to 13.0 million. We believe that our cash position of CHF 372,647 at June 30, 2022, together with revenues from Bentrio product sales, the receipt of grants, proceeds from the issuance of Common Shares under the A.G.P. Sales Agreement and the 2020 Commitment Purchase Agreement of USD 2.2 million up to the reporting date as well as from further issuances under the A.G.P. Sales Agreement and the 2022 Commitment Purchase Agreement, and the $2.2 million upfront payment we expect to receive under the Share Purchase Agreement and Option Agreement, dated October 19, 2022 and amended on November 23, 2022 (as discussed below), will fund our projected operations through the fourth quarter of 2022. We expect that our funding requirements for operations and financial obligations until the end of 2023 will amount to CHF 22.0 to 25.0 million and to CHF 17.0 to 20 million if the convertible loan provided by FiveT will be converted into Common Shares. To the extent that we will be unable to generate sufficient cash proceeds from the planned divestiture or spin-off of our legacy assets or other partnering activities, we will need substantial additional financing to meet these funding requirements.

 

We have based the above estimate on assumptions that may prove to be wrong, and we could use our capital resources sooner than we currently expect. Our future funding requirements will depend on many factors, including but not limited to:

 

●

the ability to monetize our legacy assets, including the ability to close agreed divestiture transactions, and the terms and timing of future divestiture transactions with third parties;

 

●

the scope, rate of progress, results and cost of our clinical trials, nonclinical testing, and other related activities;

 

●

the cost of manufacturing clinical supplies, and establishing commercial supplies, of our product candidates and any products that we may develop;

 

●

the number and characteristics of product candidates that we pursue;

 

●

the cost, timing, and outcomes of regulatory approvals;

 

●

the cost and timing of establishing sales, marketing, and distribution capabilities; and

 

●

the terms and timing of any collaborative, licensing, and other arrangements that we may establish, including any required milestone and royalty payments thereunder.

 

On October 21, 2022, we announced the sale of (i) 90% of the share capital of its subsidiary Zilentin AG and (ii) an option to purchase the subsidiaries Auris Medical AG, Otolanum AG, Auris Medical Ltd. and Auris Medical Pty Ltd (the “Additional Subsidiaries”) – representing our inner ear therapeutic assets – to a European family office (the “Buyer”) for a cash consideration of USD 1 million each, for a total of USD 2 million. Under the terms of the option agreement (the “Option”) Zilentin will be entitled to purchase the Additional Subsidiaries for an upfront payment of USD 25 million plus potential milestone royalty payments. The Option may be exercised for 30 days from October 19, 2022 (the “Closing Date”); beyond that period, Zilentin will have a right of first refusal to acquire these companies until year end with the upfront payment increasing by USD 1 million per month. There is no assurance that Buyer will exercise its option, triggering the additional upfront payment of USD 25 million. Due to a delay in the closing of the Zilentin Transaction, the Company and the Buyer agreed on November 23, 2022 to amend their agreement, extending the Closing Date to December 15, 2022 at the latest, increasing the share capital of Zilentin AG to be sold under the transaction from 90 to 100% and raising the amount of the initial payment for the purchase of Zilentin and for the option to purchase the Additional Subsidiaries from USD 2 million to USD 2.2 million.

 

Apart from the inner ear therapeutic assets, we intend to spin off or divest also our OTC consumer health products business, in order to focus on the development of our OligoPhore/SemaPhore RNA delivery platform.

 

We expect that we will require additional funding, including under the 2020 Commitment Purchase Agreement and A.G.P. Sales Agreement to continue our ongoing clinical development activities and seek to obtain regulatory approval for, and commercialize, our product candidates. If we receive regulatory approval for any of our product candidates, and if we choose not to grant any licenses to partners, we expect to incur significant commercialization expenses related to product manufacturing, sales, marketing and distribution, depending on where we choose to commercialize. Additional funds may not be available on a timely basis, on favorable terms, or at all, and such funds, if raised, may not be sufficient to enable us to continue to implement our long-term business strategy. If we are not able to raise capital when needed, we could be forced to delay, reduce or eliminate our product development programs or commercialization efforts.

 

On June 3, 2021, in connection with the acquisition of Trasir, we announced our intention to reposition the Compound around RNA therapeutics and to prepare for the separation of the Company’s legacy assets either through a divestiture or a spin-off to shareholders within the next 12-18 months. At this point, there can be no assurance that the Buyer and Zilentin will exercise the Option or purchase the Additional Subsidiaries under its right of first refusal or that the Company will be successful in its efforts to divest the Bentrio™ asset in the near term and/or at reasonable and attractive terms and conditions. Should the Company be unable to execute on the divestiture of both the Additional Subsidiaries and Bentrio™, it may have to reduce or stop certain activities and will have to raise additional capital through the sale of equity or convertible debt securities. In such an event, the ownership interest of the Company’s current shareholders will be diluted, and the terms of these new securities may include liquidation or other preferences that adversely affect their rights as a holder of our common shares.

 

For more information as to the risks associated with our future funding needs, see “Item 3—Key Information-D. Risk factors” in the Annual Report.

 

 

Contractual Obligations and Commitments                  

 

The following table presents information relating to our contractual obligations as of June 30, 2022:          

 

		Payments Due by Period
		Less Than				Between				Between
		1 Year				1 and 3 Years				3 and 5				Years Total
						(in thousands of CHF)
Convertible loan			5,000				—				—				5,000
Loan agreement			600				—				—				600
Lease obligations (3)			3				—				—				3
Total			5,603				—				—				5,603

 

(1)	On February 4, 2022, the Company entered into a convertible loan agreement with FiveT Investment Management Ltd. The loan bears interest at the rate of 10% and matures 12 months from the disbursement date, if not converted into common shares.

(2)

On September 9, 2022 the Company entered into a loan agreement with FiveT Investment Management Ltd., Dominik Lysek and Thomas Meyer. The loan bears interest at the rate of 5% and matures as of March 31, 2023.

(3)

Lease obligations consist of payments pursuant to a short-term lease agreement not accounted for on the balance sheet. The lease term is indefinite and can be terminated with a six month notice period.

 

Under the terms of our collaboration and license agreement with Xigen, we are obliged to make development milestone payments on an indication-by-indication basis of up to CHF 1.5 million upon the successful completion of a Phase 2 clinical trial and regulatory milestone payments on a product-by-product basis of up to CHF 2.5 million, subject to a mid-twenties percentage reduction for smaller indications, e.g., those qualifying for orphan drug status, upon receiving marketing approval for a product. The milestones are not included in the table above as they have not met the recognition criteria for provisions and the timing of these is not yet determinable as it is dependent upon the achievement of earlier mentioned milestones.

 

Under the terms of the asset purchase agreement with Otifex Therapeutics Pty Ltd, we made a one-time, final development milestone payment of USD 100,000 related to AM-125.

 

Off-Balance Sheet Arrangements

 

As of the date of this discussion and analysis, we do not have any, and during the periods presented we did not have any, off-balance sheet arrangements except for the short-term lease mentioned in “Item 5—Operating and Financial Review and Prospects-F. Tabular disclosure of contractual obligations” in the Annual Report.

 

Significant Accounting Policies and Use of Estimates and Judgment

 

There have been no material changes to the significant accounting policies and estimates described in “Item 5—Operating and Financial Review and Prospects–A. Operating results—Significant accounting policies and use of estimates and judgment” in the Annual Report.

 

Recent Accounting Pronouncements

 

See Note 4 to our audited financial statements included in our most recent Annual Report on Form 20-F for a full description of recent accounting pronouncements, including the expected dates of adoption and effects on the Company’s financial condition, results of operations and cash flows.

 

 

Cautionary Statement Regarding Forward Looking Statements

 

Forward-looking statements appear in a number of places in this discussion and analysis and include, but are not limited to, statements regarding our intent, belief or current expectations. Forward-looking statements are based on our management’s beliefs and assumptions and on information currently available to our management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including, but not limited to:

 

●

our operation as a development-stage company with limited operating history and a history of operating losses;

 

●

the COVID-19 outbreak, which continues to evolve, and which could significantly disrupt our preclinical studies and clinical trials, and therefore our receipt of necessary regulatory approvals;

 

●

our need for substantial additional funding to continue the development of our product candidates before we can expect to become profitable from sales of our products and the possibility that we may be unable to raise additional capital when needed, particularly in light of the global outbreak of the novel coronavirus, which continues to evolve;

 

●

the timing, scope, terms and conditions of a potential divestiture or spin-off of the Company’s traditional business as well as the cash such transaction(s) may generate;

 

●

the market acceptance and resulting sales from Bentrio™ in international markets;

 

●

our dependence on the success of AM-125, AM-301, AM-401, AM-411, Keyzilen® (AM-101) and Sonsuvi® (AM-111), which are still in clinical development, may eventually prove to be unsuccessful;

 

●

the chance that we may become exposed to costly and damaging liability claims resulting from the testing of our product candidates in the clinic or in the commercial stage;

 

●

the chance our clinical trials may not be completed on schedule, or at all, as a result of factors such as delayed enrollment or the identification of adverse effects, particularly in light of the global outbreak of the novel coronavirus, which continues to evolve;

 

●

uncertainty surrounding whether any of our product candidates will receive regulatory approval, which is necessary before they can be commercialized;

 

●

if our product candidates obtain regulatory approval, our product candidates being subject to expensive, ongoing obligations and continued regulatory overview;

 

●

enacted and future legislation may increase the difficulty and cost for us to obtain marketing approval and commercialization;

 

●

the chance that we do not obtain orphan drug exclusivity for Sonsuvi®, which would allow our competitors to sell products that treat the same conditions;

 

●

dependence on governmental authorities and health insurers establishing adequate reimbursement levels and pricing policies;

 

●

our products may not gain market acceptance, in which case we may not be able to generate product revenues;

 

●

our reliance on our current strategic relationships with INSERM or Xigen and the potential success or failure of strategic relationships, joint ventures or mergers and acquisitions transactions;

 

●

our reliance on third parties to conduct our nonclinical and clinical trials and on third-party, single-source suppliers to supply or produce our product candidates;

 

●

our ability to obtain, maintain and protect our intellectual property rights and operate our business without infringing or otherwise violating the intellectual property rights of others;

 

●

our ability to meet the continuing listing requirements of Nasdaq and remain listed on The Nasdaq Capital Market;

 

●

the chance that certain intangible assets related to our product candidates will be impaired; and

 

●

other risk factors set forth in our most recent Annual Report on Form 20-F.

 

Our actual results or performance could differ materially from those expressed in, or implied by, any forward-looking statements relating to those matters. Accordingly, no assurances can be given that any of the events anticipated by the forward-looking statements will transpire or occur, or if any of them do so, what impact they will have on our results of operations, cash flows or financial condition. Except as required by law, we are under no obligation, and expressly disclaim any obligation, to update, alter or otherwise revise any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future events or otherwise.

 

 

v3.23.2

Document And Entity Information	6 Months Ended
	Jun. 30, 2022
Document Information Line Items
Entity Registrant Name	Altamira Therapeutics Ltd.
Document Type	6-K/A
Current Fiscal Year End Date	--12-31
Amendment Flag	true
Amendment Description	This Amendment No. 1 (this “Amendment No. 1”) to the Report of Foreign Private Issuer on Form 6-K originally filed on November 30, 2022 (the “Original Form 6-K”) is being furnished solely to correct an identified misstatement. In the Unaudited Condensed Consolidated Interim Financial Statements of Altamira Therapeutics Ltd. (the “Company”) as of June 30, 2022 and for the six months ended June 30, 2022, furnished with the Securities and Exchange Commission (the “SEC”) on November 30, 2022 with the Original Form 6-K, an upfront payment of $1 million (CHF 0.9 million) related to the exclusive licensing and distribution agreement with Nuance Pharma for Bentrio® was incorrectly recorded as revenue. In the audited financial statements as of December 31, 2022 included in the Company’s Annual Report on Form 20-F filed with the SEC on May 16, 2023, the upfront payment is recorded as deferred income, following the correction of the identified misstatement. Adjustments for this correction are reflected in the restated financial statements as of and for the six months ended June 30, 2022 furnished with this Amendment No. 1 in Exhibit 99.1 and the related management’s discussion and analysis in Exhibit 99.2. This Amendment No. 1 makes no other changes to the Original 6-K, and no attempt has been made in this Amendment No. 1 to modify or update the other disclosures presented in the Original Form 6-K. This Amendment No. 1 does not reflect subsequent events occurring after the initial furnishing of the Original Form 6-K (i.e., those events occurring after November 30, 2022) or modify or update in any way those disclosures that may be affected by subsequent events. Accordingly, this Amendment No. 1 should be read in conjunction with the Reports on Form 6-K furnished, and our other filings made, with the SEC.
Entity Central Index Key	0001601936
Document Period End Date	Jun. 30, 2022
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q2
Entity File Number	001-36582

v3.23.2

Condensed Consolidated Interim Statement of Profit or Loss and Other Comprehensive Income or Loss (Unaudited) - CHF (SFr)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Condensed Consolidated Interim Statement Of Profit Or Loss And Other Comprehensive Income Or Loss Unaudited Abstract
Revenue	SFr 290,798
Cost of Sales	(1,192,232)
Gross profit	(901,434)
Other operating income	255,820
Research and development	(3,563,883)	(3,393,710)
Sales and marketing	(2,129,881)
General and administrative	(2,076,383)	(3,062,199)
Operating loss	(8,415,761)	(6,455,909)
Interest expense	(376,848)	(172,462)
Foreign currency exchange gain (loss), net	58,296	291,892
Revaluation (loss) gain from derivative financial instruments	450,847	(428,742)
Transaction costs	(1,137)
Loss before tax	(8,284,603)	(6,765,221)
Income tax gain	46,085	10,642
Net loss attributable to owners of the Company	(8,238,518)	(6,754,579)
Items that will never be reclassified to profit or loss
Remeasurement of defined benefit liability, net of taxes of CHF 0.00	209,526	448,946
Items that are or may be reclassified to Profit or loss
Foreign currency translation differences, net of taxes of CHF 0.00	(63,477)	(41,922)
Other comprehensive income/(loss), net of taxes of CHF 0	146,049	407,024
Total comprehensive loss attributable to owners of the Company	SFr (8,092,469)	SFr (6,347,555)
Basic and diluted loss per share (in Francs per share)	SFr (10.63)	SFr (10.85)

v3.23.2

Condensed Consolidated Interim Statement of Profit or Loss and Other Comprehensive Income or Loss (Unaudited) (Parentheticals)	6 Months Ended
	Jun. 30, 2022 CHF (SFr) SFr / shares	Jun. 30, 2021 CHF (SFr) SFr / shares
Condensed Consolidated Interim Statement Of Profit Or Loss And Other Comprehensive Income Or Loss Unaudited Abstract
Remeasurement of defined benefit liability, net of taxes	SFr 0	SFr 0
Foreign currency translation differences, net of taxes	0	0
Other comprehensive income/(loss), net of taxes	SFr 0	SFr 0
Diluted loss per share (in Francs per share) | (per share)	SFr (10.63)	SFr (10.85)

v3.23.2

Condensed Consolidated Interim Statement of Financial Position (Unaudited) - CHF (SFr)	Jun. 30, 2022	Dec. 31, 2021
Non-current assets
Property and equipment	SFr 1	SFr 1
Right-of-use assets	505,270	564,714
Intangible assets	15,851,501	14,314,877
Other non-current financial assets	195,421	199,105
Total non-current assets	16,552,193	15,078,697
Current assets
Inventories	146,366	839,221
Trade receivables	182,167	21,746
Other receivables	444,034	671,340
Prepayments	782,469	1,575,126
Cash and cash equivalents	372,647	984,191
Total current assets	1,927,683	4,091,624
Total assets	18,479,876	19,170,321
Equity
Share capital	170,643	149,643
Share premium	190,108,850	188,511,476
Foreign currency translation reserve	(1,408)	62,069
Accumulated deficit	(183,535,121)	(175,686,937)
Total shareholders’ equity attributable to owners of the Company	6,742,964	13,036,251
Non-current liabilities
Derivative financial instruments		1,233
Non-current lease liabilities	403,015	461,485
Employee benefits	515,174	668,319
Deferred income	932,200
Deferred tax liabilities	95,999	142,484
Total non-current liabilities	1,946,388	1,273,521
Current liabilities
Loan	4,701,906
Derivative financial instruments	284
Current lease liabilities	116,040	114,251
Trade and other payables	3,164,754	3,697,723
Accrued expenses	1,807,540	1,048,575
Total current liabilities	9,790,524	4,860,549
Total liabilities	11,736,912	6,134,070
Total equity and liabilities	SFr 18,479,876	SFr 19,170,321

v3.23.2

Condensed Consolidated Interim Statement of Changes in Equity (Unaudited) - CHF (SFr)	Share Capital	Share Premium	FX Translation Reserve	Accumulated Deficit (restated)	Total
Balance at Dec. 31, 2020	SFr 114,172	SFr 177,230,300	SFr 61,297	SFr (160,635,879)	SFr 16,769,890
Total comprehensive loss
Net loss				(6,754,579)	(6,754,579)
Other comprehensive income/(loss)			(41,922)	448,946	407,024
Total comprehensive loss			(41,922)	(6,305,633)	(6,347,555)
Transactions with owners of the Company
Capital increase /Exercise of warrants	8,974	3,885,764			3,894,738
Conversion of loan	5,168	1,366,087			1,371,255
Share based/Asset purchase	7,735	2,266,735		1,078,800	3,353,270
Share based payments	382	92,181		952,349	1,044,912
Balance at Jun. 30, 2021	136,431	184,841,067	19,375	(164,910,363)	20,086,510
Balance at Dec. 31, 2020	114,172	177,230,300	61,297	(160,635,879)	16,769,890
Balance at Dec. 31, 2021	149,643	188,511,476	62,069	(175,686,937)	13,036,251
Balance at Jun. 30, 2021	136,431	184,841,067	19,375	(164,910,363)	20,086,510
Balance at Jun. 30, 2022	170,643	190,108,850	(1,408)	(183,535,121)	6,742,964
Balance at Dec. 31, 2021	149,643	188,511,476	62,069	(175,686,937)	13,036,251
Total comprehensive loss
Net loss				(8,238,518)	(8,238,518)
Other comprehensive income/(loss)			(63,477)	209,526	146,049
Total comprehensive loss			(63,477)	(8,028,992)	(8,092,469)
Transactions with owners of the Company
Capital increase	21,000	1,597,374			1,618,374
Share based payments				180,808	180,808
Balance at Jun. 30, 2022	SFr 170,643	SFr 190,108,850	SFr (1,408)	SFr (183,535,121)	SFr 6,742,964

v3.23.2

Condensed Consolidated Interim Statement of Cash Flows (Unaudited) - CHF (SFr)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities
Net loss	SFr (8,238,518)	SFr (6,754,579)
Adjustments for:
Depreciation	59,444	23,636
Deferred income	932,200
Unrealized foreign currency exchange (gain)/loss, net	(33,129)	(318,319)
Net interest expense	366,343	170,906
Share based payments	180,808	1,044,912
Employee benefits	56,381	26,101
Transaction costs	1,138
Fair value derivative financial instruments	(450,847)	428,742
Deferred tax (gain)/loss	(47,316)	(10,642)
Total	(7,173,496)	(5,389,243)
Changes in:
Inventories	692,855	(196,415)
Other receivables	23,346	(59,446)
Prepayments	785,834	(66,403)
Trade and other payables	(419,075)	714,292
Accrued expenses	506,806	78,646
Net cash used in operating activities	(5,583,730)	(4,918,569)
Cash flows from investing activities
Purchase of intangibles	(1,533,568)	(1,988,907)
Net cash used in investing activities	(1,533,568)	(1,988,907)
Cash flows from financing activities
Proceeds from equity issuance and public offering	1,618,374	3,894,739
Proceeds from loan	4,988,626
Repayment of loan		(50,000)
Repayment of lease liability	(56,682)
Interest paid	(8,413)	(13)
Net cash from financing activities	6,541,905	3,844,726
Net increase/(decrease) in cash and cash equivalents	(575,393)	(3,062,750)
Cash and cash equivalents at beginning of the period	984,191	11,258,870
Net effect of currency translation on cash	(36,151)	270,878
Cash and cash equivalents at end of the period
Cash and cash equivalents at end of the period	SFr 372,647	SFr 8,466,998

v3.23.2

Reporting Entity	6 Months Ended
	Jun. 30, 2022
Reporting Entity [Abstract]
Reporting entity	1. Reporting entity   Altamira Therapeutics Ltd. (the “Company”) is an exempted company incorporated under the laws of Bermuda. The Company began its operations as a corporation organized in accordance with Swiss law and domiciled in Switzerland under the name Auris Medical Holding AG (“Auris Medical (Switzerland)”). Following shareholder approval at an extraordinary general meeting of shareholders held on March 8, 2019 and upon the issuance of a certificate of continuance by the Registrar of Companies in Bermuda on March 18, 2019, the Company discontinued as a Swiss company and, pursuant to Article 163 of the Swiss Federal Act on Private International Law and pursuant to Section 132C of the Companies Act 1981 of Bermuda (the “Companies Act”), continued existence under the Companies Act as a Bermuda company with the name “Auris Medical Holding Ltd.” (the “Redomestication”). On March 18, 2019, the common shares of the Company began trading on the Nasdaq Capital Market under the trading symbol “EARS”. The Company’s registered office is located at Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda. On July 21, 2021, the Company changed its name to Altamira Therapeutics Ltd. Since July 26, 2021, the Company’s common shares are traded under the trading symbol “CYTO”. On October 25, 2022, the Company effected a one-for-twenty reverse share split (the “2022 Reverse Share Split”) of the Company’s issued and outstanding common shares. Unless indicated or the context otherwise requires, all per share amounts and numbers of common shares in this report have been retrospectively adjusted for the 2022 Reverse Share Split, as if such 2022 Reverse Share Split occurred on the first day of the periods presented.   These condensed consolidated interim financial statements comprise the Company and its subsidiaries (together referred to as the “Group” and individually as “Group entities”). The Company is the ultimate parent of the following Group entities:   ● Auris Medical AG, Basel, Switzerland (100%) with a nominal share capital of CHF 2,500,000   ● Otolanum AG, Zug, Switzerland (100%) with a nominal share capital of CHF 100,000   ● Altamira Therapeutics, Inc., Dover, Delaware, United States (100%) with a nominal share capital of USD 100   ● Auris Medical Ltd., Dublin, Ireland (100%) with a nominal share capital of EUR 100   ● Zilentin AG, Zug, Switzerland (100%) with a nominal share capital of CHF 100,000   ● Auris Medical Pty Ltd, Collingwood, Australia (100%) with a nominal share capital of AUD 100   ● Altamira Medica AG, Zug, Switzerland (100%) with a nominal share capital of CHF 3,000,000   The Group is primarily involved in the development of novel products that address important unmet medical needs through RNA therapeutics, allergy and viral infection protection, and inner ear therapeutics. The Group is focusing on the development of RNA therapeutics for extrahepatic therapeutic targets (AM-401 and AM-411), nasal sprays for protection against airborne viruses and allergens (AM-301; Bentrio™) or the treatment of vertigo (AM-125), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (AM-101; Keyzilen® and AM-111; Sonsuvi®).

v3.23.2

Basis of Preparation Statement of Compliance	6 Months Ended
	Jun. 30, 2022
Basis of Preparation [Abstract]
Basis of preparation Statement of compliance	2. Basis of preparation Statement of compliance   These condensed consolidated interim financial statements as of June 30, 2022 and for the six months ended June 30, 2022 have been prepared in accordance with International Accounting Standard 34 Interim Financial Reporting (“IAS 34”) and should be read in conjunction with the audited consolidated financial statements as of and for the year ended December 31, 2021.   These condensed consolidated interim financial statements include all adjustments that are necessary to fairly state the results of the interim period. The Group believes that the disclosures are adequate to make the information presented not misleading. Interim results are not necessarily indicative of results to be expected for the full year. Management does not consider the business to be seasonal or cyclical.   Certain information and footnote disclosures normally included in consolidated financial statements prepared in accordance with International Financial Reporting Standards (“IFRS”), as issued by the International Accounting Standards Board, have been condensed or omitted as permitted by IAS 34. The condensed consolidated statement of financial position as of December 31, 2021 was derived from the audited consolidated financial statements.   The interim condensed consolidated financial statements were authorized for issuance by the Company’s Audit Committee on November 28, 2022   Functional and reporting currency   These interim condensed consolidated financial statements are presented in Swiss Francs (“CHF”), which is the Company’s functional currency (“functional currency”) and the Group’s reporting currency.   Significant accounting policies   The accounting policies applied by the Group in these condensed consolidated interim financial statements are the same as those applied by the Group in its audited consolidated financial statements as of and for the year ended December 31, 2021 and have been applied consistently to all periods presented in these condensed consolidated interim financial statements, unless otherwise indicated.   New standards, amendments and interpretations adopted by the Group   Amendments to IAS 16   Property, Plant and Equipment: Proceeds before Intended Use Amendments to IAS 37   Provisions, Contingent Liabilities and Contingent Assets - Onerous contracts – Costs of fulfilling a Contract Amendments to IFRS 3   Business Combinations - Reference to the Conceptual Framework Annual Improvements to IFRS Standards 2018-2020 – Amendments to IFRS 1, IFRS 9, IFRS 16, IAS 41   The application of these new standards, amendments to standards and interpretations does not have material impact on the financial statements of the Group.   Convertible loan   The convertible loan obtained from FiveT Investment Management Ltd. (see Note 5) is classified as a hybrid contract containing a host that is a financial liability and embedded derivatives separated from the host and measured at fair value with all changes in fair value recognized in profit or loss. The embedded financial derivatives are valued by an independent consultant initially and at period end at fair value, applying a simulation-based valuation approach.   The carrying amount of the host contract at initial recognition is the difference between the carrying amount of the hybrid contract and the fair value of the embedded derivatives. The host is then subsequently measured at amortized cost, using the effective interest rate method.   Intangible assets   As of June 30, 2022, Intangible assets amounted to CHF 15,851,501, compared to CHF 14,314,877 as of December 31, 2021. The increase is due to the capitalization of development costs related to the AM-125 program.   Going concern   The Company has incurred recurring losses and negative cash flows from operations since inception and it expects to generate losses from operations for the foreseeable future primarily due to research and development costs for its potential product candidates. The Company believes its cash of CHF 372,647 at June 30, 2022, together with revenues from Bentrio product sales, the receipt of grants, proceeds from the issuance of Common Shares under the A.G.P. Sales Agreement and the 2020 Commitment Purchase Agreement of USD 2.2 million up to the reporting date as well as from further issuances under the A.G.P. Sales Agreement and the 2022 Commitment Purchase Agreement, and the USD 2.2 million upfront payment it expects to receive under the Share Purchase Agreement and Option Agreement, dated October 19, 2022 and amended on November 23, 2022 (as discussed below), will fund the Company’s projected operations through the fourth quarter of 2022. We expect that our funding requirements for operations and financial obligations until the end of 2023 will amount to CHF 22.0 to 25.0 million and to CHF 17.0 to 20 million if the convertible loan provided by FiveT will be converted into Common Shares. To the extent that we will be unable to generate sufficient cash proceeds from the planned divestiture or spin-off of our legacy assets or other partnering activities, we will need substantial additional financing to meet these funding requirements both through the fourth quarter of 2022 and thereafter. These factors raise substantial doubt about the Company’s ability to continue as a going concern. The financial statements have been prepared on a going concern basis, which contemplates the continuity of normal activities and realisation of assets and settlement of liabilities in the normal course of business. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.   As is often the case with drug development companies, the ability of the consolidated entity to continue its development activities as a going concern is dependent upon it deriving sufficient cash from investors, from licensing and partnering activities, in particular the intended divestiture or spin-off of the Company’s legacy assets in the fields of inner ear therapeutics and OTC consumer health products, and from other sources of revenue such as grant funding.   On October 21, 2022, the Company announced the sale of (i) 90% of the share capital of its subsidiary Zilentin AG and (ii) an option to purchase the subsidiaries Auris Medical AG, Otolanum AG, Auris Medical Ltd. and Auris Medical Pty Ltd (the “Additional Subsidiaries”) – representing the Company’s inner ear therapeutic assets – to a European family office (the “Buyer”) for a cash consideration of USD 1 million each, for a total of USD 2 million (the “Zilentin Transaction”). Under the terms of the option agreement (the “Option”) Zilentin will be entitled to purchase the Additional Subsidiaries for an upfront payment of USD 25. million plus potential milestone royalty payments. The Option may be exercised for 30 days from October 19, 2022 (the “Closing Date”); beyond that period, Zilentin will have a right of first refusal to acquire these companies until year end with the upfront payment increasing by USD 1 million per month. There is no assurance that Buyer will exercise its option, triggering the additional upfront payment of USD 25 million. Due to a delay in the closing of the Zilentin Transaction, the Company and the Buyer agreed on November 23, 2022 to amend their agreement, extending the Closing Date to December 15, 2022 at the latest, increasing the share capital of Zilentin AG to be sold under the transaction from 90 to 100% and raising the amount of the initial payment for the purchase of Zilentin and for the option to purchase the Additional Subsidiaries from USD 2 million to USD 2.2 million.   The directors have considered the cash flow forecasts and the funding requirements of the business and continue to explore grant funding, licensing opportunities and equity investment opportunities in the Company. Apart from the inner ear therapeutic assets, the Company intends to spin off or divest also its OTC consumer health products business, in order to focus on the development of its OligoPhore/SemaPhore RNA delivery platform. At the date of issuing these financial statements, such plans have not yet been realized.   Accordingly, the directors have prepared the financial statements on a going concern basis. Should the above assumptions not prove to be appropriate, there is material uncertainty whether the consolidated entity will continue as a going concern and therefore whether it will realize its assets and extinguish its liabilities in the normal course of business and at the amounts stated in these financial statements.   The Company plans to secure additional capital in the future through equity or debt financings, partnerships, collaborations, or other sources to carry out the Company’s planned development activities. If additional capital is not available when required, the Company may need to delay or curtail its operations until such funding is received. Various internal and external factors will affect whether and when the Company’s product candidates become approved for marketing and successful commercialization. The regulatory approval and market acceptance of the Company’s product candidates, length of time and cost of developing and commercializing these product candidates and/or failure of them at any stage of the approval process will materially affect the Company’s financial condition and future operations. Such matters are not within the control of the Company and thus all associated outcomes are uncertain.   Accounting for divestiture   From the date of entering into the agreement for the disposal of Zilentin and the sale of the purchase option for the Additional Subsidiaries, the respective assets and liabilities are classified as held for sale and measured at the lower of carrying amount and fair value less costs to sell. As the agreement was entered into after June 30, 2022, and consequently the criteria for held for sale were met only after the reporting period, the disposal group is presented in the subsequent events and not yet as held for sale in the financial statements. The assets held for sale mainly comprise capitalized development costs related to the AM-125 program, which amounted to CHF 12.0 million as of June 30, 2022.   Adjustment of June 30, 2022 Revenue   In the Company's Unaudited Condensed Consolidated Interim Financial Statements as of June 30, 2022 and for the six months ended June 30, 2022, furnished with the SEC on November 30, 2022 with a Report of Foreign Private Issuer on Form 6-K (the “Original Form 6-K”), an upfront payment of $1 million (CHF 0.9 million) related to the exclusive licensing and distribution agreement with Nuance Pharma for Bentrio® was incorrectly recorded as revenue. In the audited financial statements as of December 31, 2022 included in the Company’s Annual Report on Form 20-F filed with the SEC on May 16, 2023, the upfront payment was recorded as deferred income, following the correction of the identified misstatement. Adjustments for this correction are reflected in these restated condensed consolidated interim financial statements as of June 30, 2022 and for the six months ended June 30, 2022. The table below reflects the impact of the adjustments on key income statement and balance sheet line items.   Six months ended June 30, 2022   Adjusted consolidated Balance Sheet       As of June 30, 2022       As reported     Adjustment     Adjusted   Deferred income     -       932,200       932,200   Total non-current liabilities     1,014,188       932,200       1,946,388   Total liabilities     10,804,712       932,200       11,736,912   Accumulated deficit     (182,602,921 )     (932,200 )     (183,535,121 ) Total shareholders’ equity attributable to owners of the company     7,675,164       (932,200 )     6,742,964     Adjusted consolidated Statement of Profit or Loss and Other Comprehensive Loss       Half-Year ended June 30, 2022       As reported     Adjustment     Adjusted   Revenue     1,222,998       (932,200 )     290,798   Gross profit     30,766       (932,200 )     (901,434 ) Operating loss     (7,483,561 )     (932,200 )     (8,415,761 ) Loss before tax     (7,352,403 )     (932,200 )     (8,284,603 ) Net loss attributable of owners of the Company     (7,306,318 )     (932,200 )     (8,238,518 ) Total comprehensive loss attributable to owners of the Company     (7,160,269 )     (932,200 )     (8,092,469 ) Basic and diluted loss per share     (9.43 )     (1.20 )     (10.63 )

v3.23.2

Taxation	6 Months Ended
	Jun. 30, 2022
Taxation [Abstract]
Taxation	3. Taxation   The Group’s income tax expense recognized in the condensed interim consolidated statement of profit or loss is presented as follows:       Six Months Ended       June 30,     June 30,       2022     2021   Current income tax expense     (1,231 )     —   Deferred income tax gain     47,316       10,642   Total income tax (expense)/gain     46,085       10,642     The tax effect of taxable temporary differences that give rise to deferred income tax liabilities or to deferred income tax assets as of June 30, 2022 and 2021 is presented as follows:       June 30,     December 31,       2022     2021   Deferred Tax liabilities             Intangible assets     (47,590 )     (51,914 ) Other receivables     (81,184 )     (122,449 ) Total     (128,774 )     (174,363 ) Deferred Tax assets                 Net operation loss (NOL)     32,775       31,879   Total     32,775       31,879   Deferred Tax, net     (95,999 )     (142,484 )

v3.23.2

Capital and Reserves	6 Months Ended
	Jun. 30, 2022
Capital and Reserves [Abstract]
Capital and reserves	4. Capital and reserves   Share capital   The issued share capital of the Company consisted of:       Common Shares       Number       2022     2021   As of January 1     748,213       570,858   Common shares issued     105,000       111,299   Total, as of June 30     853,213       682,157     As of June 30, 2022, the par value of the 853,213 issued shares amounted to CHF 170,643 with a par value of CHF 0.20 for each common share (as of June 30, 2021, the par value of 682,157 issued shares amounted to CHF 136,431 with a par value of CHF 0.20 for each common share).   Equity Offerings   On June 1, 2021, the company completed the acquisition of Trasir Therapeutics Inc. The upfront acquisition price of USD 2.5 million was paid with 38,218 non-registered common shares at the Reference Price of USD 65.40 to the selling shareholders. In addition, 459 non-registered common shares were issued based on the Reference Price to reimburse USD 30,000 in expenses incurred by certain selling Trasir shareholders.   On March 4, 2021, the remaining convertible loan by FiveT in the amount of CHF 604,545 plus accumulated interests of CHF 40,268 was converted into 25,841 common shares at a conversion price of USD 27.00.   On April 23, 2020, the Company entered into a purchase agreement and a Registration Rights Agreement with Lincoln Park Capital Fund, LLC (the “2020 Commitment Purchase Agreement”). Pursuant to the 2020 Commitment Purchase Agreement, LPC agreed to subscribe for up to USD 10,000,000 of our common shares over the 30-month term of the 2020 Commitment Purchase Agreement. Through June 30, 2022, we issued a total of 165,000 of our common shares to LPC for an aggregate amount of USD 2,806,605 under the 2020 Commitment Purchase Agreement. During the six months ended June 30, 2022, we issued 105,000 of our common shares to LPC for an aggregate amount of USD 1,698,450 under the 2020 Commitment Purchase Agreement, and as of the date of this report, we have issued a total of 325,000 of our common shares to LPC for an aggregate amount of USD 4,003,820 under the 2020 Commitment Purchase Agreement.   The remaining 44,872 warrants of the May 2019 Registered Offering were exercised in March 2021.   On November 30, 2018, as amended on April 5, 2019 the Company entered into a sales agreement, as amended (the “A.G.P. Sales Agreement”) with A.G.P./Alliance Global Partners (“A.G.P.”). Pursuant to the terms of the A.G.P. Sales Agreement, the Company may offer and sell its common shares, from time to time through A.G.P. by any method deemed to be an “at-the-market” offering as defined in Rule 415(a)(4) promulgated under the Securities Act. Pursuant to the A.G.P. Sales Agreement, the Company may sell common shares up to a maximum aggregate offering price of USD 25.0 million. As of June 30, 2022, the Company has sold a total of 147,166 common shares for an aggregate offering price of USD 6.7 million pursuant to the A.G.P. Sales Agreement (June 30, 2021: 87,931 common shares for an aggregate offering price of USD 2.9 million), and as of the date of this report, the Company has sold a total of 228,666 common shares for an aggregate offering price of USD 7.8 million pursuant to the A.G.P. Sales Agreement.   As of June 30, 2022 the fair value of the warrants issued in the January 2018 Registered Offering amounted to zero. Therefore, the fair value decreased by the total amount of CHF 1,233 in the first six months of 2022 (fair value as of December 31, 2021: CHF 1,233).   The warrants issued in the February 2017 public offering expired on February 22, 2022, without any warrants having been exercised.   Issue of common shares upon exercise of options   During the six months ended June 30, 2022, no options were exercised.

v3.23.2

Loans	6 Months Ended
	Jun. 30, 2022
Loans [Abstract]
Loans	5. Loans   On February 4, 2022, the Company entered into a convertible loan agreement (the “Loan Agreement”) with FiveT Investment Management Ltd. (the “Lender”), pursuant to which the Lender has agreed to loan to the Company CHF 5,000,000 (the “Loan”), which Loan bears interest at the rate of 10% per annum and matures 12 months from the date (the “Disbursement Date”) the Loan proceeds were disbursed to the Company, which occurred on February 8, 2022. The Company may prepay all or part of the Loan after six months after the Disbursement Date; provided that the Company will pay an amount equal to 130% of the desired prepayment amount. The Lender has the right to convert all or part of the Loan, including accrued and unpaid interest, at its option, into common shares, subject to the limitation that the Lender own no more than 9.99% of the common shares at any time. The conversion price of the Loan into common shares is USD 38.916, which corresponds to 150% of USD 25.944 (the trading volume weighted average price, the “VWAP”, per common share on the NASDAQ stock exchange on the Disbursement Date), converted into Swiss Francs at the midpoint of the interbank exchange rate shown by UBS on the day of receipt of the conversion notice at 4:00 pm Central European Time. The conversion price shall be lowered in the event that the Company raises equity before the maturity date of the Loan through a public or private offering of common shares at an issue price that is at least 10 (ten)  % below the VWAP (the “New Issue”), according to the formula set forth in the Loan Agreement (the “Adjustment”). Sales of common shares through equity line or at-the-market programs are not considered New Issues triggering the Adjustment.   As of June 30, 2022, the carrying amount of the host for the unconverted outstanding loan amounted to CHF 4,701,906 and is included in the balance sheet under current liabilities. The fair value of the embedded derivatives amounted to CHF 284 (at initial recognition February 8, 2022: CHF 449,898) included in current derivative financial instruments. A revaluation gain related to fair value measurement of embedded derivatives of CHF 449,614 as well as effective interest expenses and transaction costs of CHF 359,068 in total were recorded in profit or loss.   Due to the COVID-19 pandemic, Swiss banks granted special COVID-19 loans under certain conditions with a guarantee by the Swiss Government. Our Company was eligible for a loan of CHF 50,000, which was granted on March 26, 2020. The loan is interest-free and may be repaid at any time with a maximum term of five years. We repaid the entire loan as of June 16, 2021.

v3.23.2

Employee Benefits	6 Months Ended
	Jun. 30, 2022
Employee Benefits [Abstract]
Employee Benefits	6. Employee benefits       Six Months Ended       June 30,     June 30,       2022     2021   Salaries     1,439,578       812,158   Pension costs     132,784       66,002   Share based compensation expense     180,808       969,739   Other employee costs and social benefits     157,358       257,108   Total employee benefits     1,910,528       2,105,007     Expenditures for employee benefits increased in the first six months ended June 30, 2022 primarily due to increased headcount compared to the first six months ended June 30, 2021. Share based compensation included expense related to employee stock options of CHF 180,808 in the first six months ended June 30, 2022 compared to CHF 159,487 in the first six months ended June 30, 2021. In 2021, share based compensation expense included CHF 810,252 for a share bonus grant related to the strategic repositioning of the Company, including CHF 360,112 for a future share grant contingent on achieving certain results related to the Trasir transaction.   A total of 27,861 options were granted in the six months ended June 30, 2022 (6,862 options in the corresponding six-month period in 2021). The exercise price of the options granted as share based compensation under the Equity Incentive Plan was USD 20.80 (for the six months ended June 30, 2021 USD 70.20). The methodology for computation of share based compensation expense for the period is consistent with the methodology used in 2021.

v3.23.2

Write-down of Inventories	6 Months Ended
	Jun. 30, 2022
Write-down of Inventories [Abstract]
Write-down of inventories	7. Write-down of inventories   The Company’s inventory consists of the product Bentrio, a drug-free nasal spray for protection against airborne viruses and allergens. Bentrio has a limited shelf life, which may affect the salability of the product, and is packaged in various configurations (stock keeping units, “SKUs”) for different markets. During the six months ended June 30, 2022, the Company wrote down finished goods inventories by CHF 764,844, based on a management review for any obsolete or slow-moving items. The write-down is included in Cost of Sales in the condensed consolidated statement of profit or loss and other comprehensive income. There were no inventory write-downs recognized during the six months ended June 30, 2021.

v3.23.2

Revision of Prior Period Financial Statements	6 Months Ended
	Jun. 30, 2022
Disclosure Of Separate Financial Statements Text Block Abstract
Revision of Prior Period Financial Statements	8. Revision of Prior Period Financial Statements   In connection with the preparation of our consolidated financial statements, we identified an immaterial error with regard to advance payments for research and development costs and related tax credits for the annual period ended December 31, 2021. The error was mainly related to investigator float payments to a contract research organization. Due to COVID and other reasons, the scheduled services had not been provided by the end of the year and therefore the payments should have been recognized as advance payments and not as R&D expenses. We evaluated the error and determined that the related impact was not material to our financial statements for any prior periods, but that correction of the impact of the error would be significant to our results of operations for the six months ended June 30, 2022. Accordingly, we have revised previously reported financial information for such immaterial error, as previously disclosed in our Annual Report on Form 20-F for the year ended December 31, 2021. A summary of revisions to our previously reported financial statements presented herein for comparative purposes is included below.   Revised consolidated Balance Sheet                   As of December 31, 2021       As reported     Adjustment     As revised   Other receivables     917,833       (246,493 )     671,340   Prepayments     996,910       578,216       1,575,126   Total current assets     3,759,901       331,723       4,091,624   Total assets     18,838,598       331,723       19,170,321   Accumulated deficit     (176,018,660 )     331,723       (175,686,937 ) Total shareholders’ equity attributable to owners of the company     12,704,528       331,723       13,036,251   Total equity and liabilities     18,838,598       331,723       19,170,321     Revised consolidated Statement of Profit or Loss and Other Comprehensive Loss                               Year ended December 31, 2021       As reported     Adjustment     As revised   Other income     460,710       (246,493 )     214,217   Research and development     (8,939,037 )     578,216       (8,360,821 ) Total operating expenses     (15,137,338 )     331,723       (14,805,615 ) Operating loss     (17,099,793 )     331,723       (16,768,070 ) Loss before tax     (17,368,546 )     331,723       (17,036,823 ) Net loss attributable of owners of the Company     (17,390,166 )     331,723       (17,058,443 ) Total comprehensive loss attributable to owners of the Company     (17,124,410 )     331,723       (16,792,687 ) Basic and diluted loss per share     (26.26 )     0.50       (25.76 )   Basic and diluted loss per share as presented in the financial statements as of December 31, 2021, prior to the one-for-twenty reverse share split on October 25, 2022 was CHF 1.31, and the revised number would have been CHF 1.29.   Revised consolidated Statement of Cash Flows   We revised our consolidated statement of cash flows for the year ended December 31, 2021. There was no impact on net cash used in operating activities.       Year ended December 31, 2021       As reported     Adjustment     As revised   Net loss     (17,390,166 )     331,723       (17,058,443 ) Changes in:                         Trade and other receivables     (586,612 )     246,493       (340,119 ) Prepayments     (719,321 )     (578,216 )     (1,297,537 ) Cash used in operating activities     (13,627,738 )     —       (13,672,738 )

v3.23.2

Loss Per Share	6 Months Ended
	Jun. 30, 2022
Loss Per Share [Abstract]
Loss per share	9. Loss per share       Six Months Ended       June 30,             2022     June 30,       (restated)     2021   Loss attributable to owners of the Company     (8,238,518 )     (6,754,579 ) Weighted average number of shares outstanding     774,898       622,741   Basic and diluted loss per share     (10.63 )     (10.85 )   For the six months ended June 30, 2022 and June 30, 2021 basic and diluted loss per share are calculated based on the weighted average number of shares issued and outstanding and excludes shares to be issued under the stock option plans or for warrants, as they would be anti-dilutive. As of June 30, 2022, the Company had 94,337 options outstanding under its stock option plan. The average number of options outstanding between January 1, 2022 and June 30, 2022 was 74,996 (54,025 for the period between January 1, 2021 and June 30, 2021).

v3.23.2

Events After the Reporting Period	6 Months Ended
	Jun. 30, 2022
Events After the Reporting Period [Abstract]
Events after the Reporting Period	10. Events after the Reporting Period   Loan Agreement   On September 9, 2022 the Company entered into a loan agreement with FiveT Investment Management Ltd., Dominik Lysek and Thomas Meyer (the “Lenders”), pursuant to which the Lenders have agreed to loan to the Company an aggregate of CHF 600,000.00, which loan bears interest at the rate of 5% per annum and matures as of March 31, 2023. The Company agreed to grant to the Lenders warrants (the “Warrants”) to purchase an aggregate 41,667 common shares. The Warrants will be exercisable at an exercise price of CHF 7.20 per share for up to five years from October 1, 2022.   Divestiture of inner ear therapeutic assets   On October 21, 2022, the Company announced the sale of 90% of the share capital of its subsidiary Zilentin AG and of an option to purchase the subsidiaries Auris Medical AG, Otolanum AG, Auris Medical Ltd. and Auris Medical Pty Ltd (the “Additional Subsidiaries”) – representing the Company’s inner ear therapeutic assets – to a European family office (the “Buyer”) for a cash consideration of USD 1 million each. Under the terms of the option agreement (the “Option”) Zilentin will be entitled to purchase the Additional Subsidiaries for an upfront payment of USD 25 million plus up to USD 55 million upon reaching certain clinical and regulatory milestones as well as royalties on revenues generated with products based on Altamira’s RNA delivery technology for certain inner ear targets at a mid-single digit percentage. The Option may be exercised for 30 days from October 19, 2022 (the “Closing Date”); beyond that period, Zilentin will have a right of first refusal to acquire these companies until year end with the upfront payment increasing by USD 1 million per month. Due to a delay in the closing of the Zilentin Transaction, the Company and the Buyer agreed on November 23, 2022 to amend their agreement, extending the Closing Date to December 15, 2022 at the latest, increasing the share capital of Zilentin AG to be sold under the transaction from 90 to 100% and raising the amount of the initial payment for the purchase of Zilentin and for the option to purchase the Additional Subsidiaries from USD 2 million to USD 2.2 million.   Subsequent to June 30, 2022, and after completion of the disposal of Zilentin and the sale of the purchase option for the Additional Subsidiaries, the respective assets and liabilities associated with the purchase option will be classified as held for sale and measured at the lower of carrying amount and fair value less costs to sell. The assets held for sale mainly comprise capitalized development costs related to the AM-125 program, which amounted to CHF 12.0 million as of June 30, 2022.   Reverse share split   On October 25, 2022, the Company effected a one-for-twenty reverse stock split. Following the share split, the Company had 1,074,713 common shares at a par value of CHF 0.20 each outstanding. No fractional common shares were issued as fractional common shares were settled in cash.   Commitment purchase agreement   On November 14, 2022, we entered into a term sheet with LPC for the conclusion of a purchase agreement under which LPC would commit to subscribe for up to USD 10,000,000 of our common shares over the 24-month term of the purchase agreement. The Company and LPC endeavor to enter into a mutually acceptable purchase agreement (the “2022 Commitment Purchase Agreement”) and related documentation within ten business days from the date of the term sheet. The Company shall pay to LPC upon signing of the 2022 Commitment Purchase Agreement a commitment fee at its sole discretion of either (i) USD 250,000 in cash or (ii) issue 50,000 Common Shares and prepare and file as soon as practicable a resale registration statement registering the shares issuable under the 2022 Commitment Purchase Agreement.

v3.23.2

Accounting Policies, by Policy (Policies)	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Functional and reporting currency	Functional and reporting currency These interim condensed consolidated financial statements are presented in Swiss Francs (“CHF”), which is the Company’s functional currency (“functional currency”) and the Group’s reporting currency.
Significant accounting policies	Significant accounting policies The accounting policies applied by the Group in these condensed consolidated interim financial statements are the same as those applied by the Group in its audited consolidated financial statements as of and for the year ended December 31, 2021 and have been applied consistently to all periods presented in these condensed consolidated interim financial statements, unless otherwise indicated.
New standards, amendments and interpretations adopted by the Group	New standards, amendments and interpretations adopted by the Group Amendments to IAS 16   Property, Plant and Equipment: Proceeds before Intended Use Amendments to IAS 37   Provisions, Contingent Liabilities and Contingent Assets - Onerous contracts – Costs of fulfilling a Contract Amendments to IFRS 3   Business Combinations - Reference to the Conceptual Framework Annual Improvements to IFRS Standards 2018-2020 – Amendments to IFRS 1, IFRS 9, IFRS 16, IAS 41 The application of these new standards, amendments to standards and interpretations does not have material impact on the financial statements of the Group.
Convertible loan	Convertible loan The convertible loan obtained from FiveT Investment Management Ltd. (see Note 5) is classified as a hybrid contract containing a host that is a financial liability and embedded derivatives separated from the host and measured at fair value with all changes in fair value recognized in profit or loss. The embedded financial derivatives are valued by an independent consultant initially and at period end at fair value, applying a simulation-based valuation approach. The carrying amount of the host contract at initial recognition is the difference between the carrying amount of the hybrid contract and the fair value of the embedded derivatives. The host is then subsequently measured at amortized cost, using the effective interest rate method.
Intangible assets	Intangible assets As of June 30, 2022, Intangible assets amounted to CHF 15,851,501, compared to CHF 14,314,877 as of December 31, 2021. The increase is due to the capitalization of development costs related to the AM-125 program.
Going concern	Going concern The Company has incurred recurring losses and negative cash flows from operations since inception and it expects to generate losses from operations for the foreseeable future primarily due to research and development costs for its potential product candidates. The Company believes its cash of CHF 372,647 at June 30, 2022, together with revenues from Bentrio product sales, the receipt of grants, proceeds from the issuance of Common Shares under the A.G.P. Sales Agreement and the 2020 Commitment Purchase Agreement of USD 2.2 million up to the reporting date as well as from further issuances under the A.G.P. Sales Agreement and the 2022 Commitment Purchase Agreement, and the USD 2.2 million upfront payment it expects to receive under the Share Purchase Agreement and Option Agreement, dated October 19, 2022 and amended on November 23, 2022 (as discussed below), will fund the Company’s projected operations through the fourth quarter of 2022. We expect that our funding requirements for operations and financial obligations until the end of 2023 will amount to CHF 22.0 to 25.0 million and to CHF 17.0 to 20 million if the convertible loan provided by FiveT will be converted into Common Shares. To the extent that we will be unable to generate sufficient cash proceeds from the planned divestiture or spin-off of our legacy assets or other partnering activities, we will need substantial additional financing to meet these funding requirements both through the fourth quarter of 2022 and thereafter. These factors raise substantial doubt about the Company’s ability to continue as a going concern. The financial statements have been prepared on a going concern basis, which contemplates the continuity of normal activities and realisation of assets and settlement of liabilities in the normal course of business. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.   As is often the case with drug development companies, the ability of the consolidated entity to continue its development activities as a going concern is dependent upon it deriving sufficient cash from investors, from licensing and partnering activities, in particular the intended divestiture or spin-off of the Company’s legacy assets in the fields of inner ear therapeutics and OTC consumer health products, and from other sources of revenue such as grant funding. On October 21, 2022, the Company announced the sale of (i) 90% of the share capital of its subsidiary Zilentin AG and (ii) an option to purchase the subsidiaries Auris Medical AG, Otolanum AG, Auris Medical Ltd. and Auris Medical Pty Ltd (the “Additional Subsidiaries”) – representing the Company’s inner ear therapeutic assets – to a European family office (the “Buyer”) for a cash consideration of USD 1 million each, for a total of USD 2 million (the “Zilentin Transaction”). Under the terms of the option agreement (the “Option”) Zilentin will be entitled to purchase the Additional Subsidiaries for an upfront payment of USD 25. million plus potential milestone royalty payments. The Option may be exercised for 30 days from October 19, 2022 (the “Closing Date”); beyond that period, Zilentin will have a right of first refusal to acquire these companies until year end with the upfront payment increasing by USD 1 million per month. There is no assurance that Buyer will exercise its option, triggering the additional upfront payment of USD 25 million. Due to a delay in the closing of the Zilentin Transaction, the Company and the Buyer agreed on November 23, 2022 to amend their agreement, extending the Closing Date to December 15, 2022 at the latest, increasing the share capital of Zilentin AG to be sold under the transaction from 90 to 100% and raising the amount of the initial payment for the purchase of Zilentin and for the option to purchase the Additional Subsidiaries from USD 2 million to USD 2.2 million. The directors have considered the cash flow forecasts and the funding requirements of the business and continue to explore grant funding, licensing opportunities and equity investment opportunities in the Company. Apart from the inner ear therapeutic assets, the Company intends to spin off or divest also its OTC consumer health products business, in order to focus on the development of its OligoPhore/SemaPhore RNA delivery platform. At the date of issuing these financial statements, such plans have not yet been realized. Accordingly, the directors have prepared the financial statements on a going concern basis. Should the above assumptions not prove to be appropriate, there is material uncertainty whether the consolidated entity will continue as a going concern and therefore whether it will realize its assets and extinguish its liabilities in the normal course of business and at the amounts stated in these financial statements. The Company plans to secure additional capital in the future through equity or debt financings, partnerships, collaborations, or other sources to carry out the Company’s planned development activities. If additional capital is not available when required, the Company may need to delay or curtail its operations until such funding is received. Various internal and external factors will affect whether and when the Company’s product candidates become approved for marketing and successful commercialization. The regulatory approval and market acceptance of the Company’s product candidates, length of time and cost of developing and commercializing these product candidates and/or failure of them at any stage of the approval process will materially affect the Company’s financial condition and future operations. Such matters are not within the control of the Company and thus all associated outcomes are uncertain.
Accounting for divestiture	Accounting for divestiture From the date of entering into the agreement for the disposal of Zilentin and the sale of the purchase option for the Additional Subsidiaries, the respective assets and liabilities are classified as held for sale and measured at the lower of carrying amount and fair value less costs to sell. As the agreement was entered into after June 30, 2022, and consequently the criteria for held for sale were met only after the reporting period, the disposal group is presented in the subsequent events and not yet as held for sale in the financial statements. The assets held for sale mainly comprise capitalized development costs related to the AM-125 program, which amounted to CHF 12.0 million as of June 30, 2022.
Adjustment Revenue	Adjustment of June 30, 2022 Revenue In the Company's Unaudited Condensed Consolidated Interim Financial Statements as of June 30, 2022 and for the six months ended June 30, 2022, furnished with the SEC on November 30, 2022 with a Report of Foreign Private Issuer on Form 6-K (the “Original Form 6-K”), an upfront payment of $1 million (CHF 0.9 million) related to the exclusive licensing and distribution agreement with Nuance Pharma for Bentrio® was incorrectly recorded as revenue. In the audited financial statements as of December 31, 2022 included in the Company’s Annual Report on Form 20-F filed with the SEC on May 16, 2023, the upfront payment was recorded as deferred income, following the correction of the identified misstatement. Adjustments for this correction are reflected in these restated condensed consolidated interim financial statements as of June 30, 2022 and for the six months ended June 30, 2022. The table below reflects the impact of the adjustments on key income statement and balance sheet line items.   Six months ended June 30, 2022 Adjusted consolidated Balance Sheet     As of June 30, 2022       As reported     Adjustment     Adjusted   Deferred income     -       932,200       932,200   Total non-current liabilities     1,014,188       932,200       1,946,388   Total liabilities     10,804,712       932,200       11,736,912   Accumulated deficit     (182,602,921 )     (932,200 )     (183,535,121 ) Total shareholders’ equity attributable to owners of the company     7,675,164       (932,200 )     6,742,964   Adjusted consolidated Statement of Profit or Loss and Other Comprehensive Loss     Half-Year ended June 30, 2022       As reported     Adjustment     Adjusted   Revenue     1,222,998       (932,200 )     290,798   Gross profit     30,766       (932,200 )     (901,434 ) Operating loss     (7,483,561 )     (932,200 )     (8,415,761 ) Loss before tax     (7,352,403 )     (932,200 )     (8,284,603 ) Net loss attributable of owners of the Company     (7,306,318 )     (932,200 )     (8,238,518 ) Total comprehensive loss attributable to owners of the Company     (7,160,269 )     (932,200 )     (8,092,469 ) Basic and diluted loss per share     (9.43 )     (1.20 )     (10.63 )

v3.23.2

Basis of Preparation Statement of Compliance (Tables)	6 Months Ended
	Jun. 30, 2022
Disclosure Of Basis Of Preparation Of Financial Statements Text Block Abstract
Schedule of adjusted consolidated balance sheet	As of June 30, 2022       As reported     Adjustment     Adjusted   Deferred income     -       932,200       932,200   Total non-current liabilities     1,014,188       932,200       1,946,388   Total liabilities     10,804,712       932,200       11,736,912   Accumulated deficit     (182,602,921 )     (932,200 )     (183,535,121 ) Total shareholders’ equity attributable to owners of the company     7,675,164       (932,200 )     6,742,964
Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss	Half-Year ended June 30, 2022       As reported     Adjustment     Adjusted   Revenue     1,222,998       (932,200 )     290,798   Gross profit     30,766       (932,200 )     (901,434 ) Operating loss     (7,483,561 )     (932,200 )     (8,415,761 ) Loss before tax     (7,352,403 )     (932,200 )     (8,284,603 ) Net loss attributable of owners of the Company     (7,306,318 )     (932,200 )     (8,238,518 ) Total comprehensive loss attributable to owners of the Company     (7,160,269 )     (932,200 )     (8,092,469 ) Basic and diluted loss per share     (9.43 )     (1.20 )     (10.63 )

v3.23.2

Taxation (Tables)	6 Months Ended
	Jun. 30, 2022
Taxation [Abstract]
Schedule of income tax expense	Six Months Ended       June 30,     June 30,       2022     2021   Current income tax expense     (1,231 )     —   Deferred income tax gain     47,316       10,642   Total income tax (expense)/gain     46,085       10,642
Schedule of deferred income tax liabilities or to deferred income tax assets	June 30,     December 31,       2022     2021   Deferred Tax liabilities             Intangible assets     (47,590 )     (51,914 ) Other receivables     (81,184 )     (122,449 ) Total     (128,774 )     (174,363 ) Deferred Tax assets                 Net operation loss (NOL)     32,775       31,879   Total     32,775       31,879   Deferred Tax, net     (95,999 )     (142,484 )

v3.23.2

Capital and Reserves (Tables)	6 Months Ended
	Jun. 30, 2022
Disclosure of Capital and Reserves [Abstract]
Schedule of Issued Share Capital	The issued share capital of the Company consisted of:     Common Shares       Number       2022     2021   As of January 1     748,213       570,858   Common shares issued     105,000       111,299   Total, as of June 30     853,213       682,157

v3.23.2

Employee Benefits (Tables)	6 Months Ended
	Jun. 30, 2022
Disclosure Of Employee Benefits Text Block Abstract
Schedule of Employee Benefits	Six Months Ended       June 30,     June 30,       2022     2021   Salaries     1,439,578       812,158   Pension costs     132,784       66,002   Share based compensation expense     180,808       969,739   Other employee costs and social benefits     157,358       257,108   Total employee benefits     1,910,528       2,105,007

v3.23.2

Revision of Prior Period Financial Statements (Tables)	6 Months Ended
	Jun. 30, 2022
Disclosure Of Separate Financial Statements Text Block Abstract
Schedule of Revised Consolidated Balance Sheet	As of December 31, 2021       As reported     Adjustment     As revised   Other receivables     917,833       (246,493 )     671,340   Prepayments     996,910       578,216       1,575,126   Total current assets     3,759,901       331,723       4,091,624   Total assets     18,838,598       331,723       19,170,321   Accumulated deficit     (176,018,660 )     331,723       (175,686,937 ) Total shareholders’ equity attributable to owners of the company     12,704,528       331,723       13,036,251   Total equity and liabilities     18,838,598       331,723       19,170,321
Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss	Year ended December 31, 2021       As reported     Adjustment     As revised   Other income     460,710       (246,493 )     214,217   Research and development     (8,939,037 )     578,216       (8,360,821 ) Total operating expenses     (15,137,338 )     331,723       (14,805,615 ) Operating loss     (17,099,793 )     331,723       (16,768,070 ) Loss before tax     (17,368,546 )     331,723       (17,036,823 ) Net loss attributable of owners of the Company     (17,390,166 )     331,723       (17,058,443 ) Total comprehensive loss attributable to owners of the Company     (17,124,410 )     331,723       (16,792,687 ) Basic and diluted loss per share     (26.26 )     0.50       (25.76 )
Schedule of Consolidated Statement of Cash Flows	We revised our consolidated statement of cash flows for the year ended December 31, 2021. There was no impact on net cash used in operating activities.     Year ended December 31, 2021       As reported     Adjustment     As revised   Net loss     (17,390,166 )     331,723       (17,058,443 ) Changes in:                         Trade and other receivables     (586,612 )     246,493       (340,119 ) Prepayments     (719,321 )     (578,216 )     (1,297,537 ) Cash used in operating activities     (13,627,738 )     —       (13,672,738 )

v3.23.2

Loss Per Share (Tables)	6 Months Ended
	Jun. 30, 2022
Disclosure Of Earnings Per Share Text Block Abstract
Schedule of loss per share	Six Months Ended       June 30,             2022     June 30,       (restated)     2021   Loss attributable to owners of the Company     (8,238,518 )     (6,754,579 ) Weighted average number of shares outstanding     774,898       622,741   Basic and diluted loss per share     (10.63 )     (10.85 )

v3.23.2

Reporting Entity (Details) - 6 months ended Jun. 30, 2022	CHF (SFr)	USD ($)	EUR (€)	AUD ($)
Auris Medical AG [Member]
Reporting Entity (Details) [Line Items]
Name of subsidiary	Auris Medical AG
Principal place of business	Basel
Country of incorporation	Switzerland
Ownership percentage in subsidiary	100.00%
Otolanum AG [Member]
Reporting Entity (Details) [Line Items]
Name of subsidiary	Otolanum AG
Principal place of business	Zug
Country of incorporation	Switzerland
Ownership percentage in subsidiary	100.00%
Altamira Therapeutics, Inc [Member]
Reporting Entity (Details) [Line Items]
Name of subsidiary	Altamira Therapeutics, Inc.
Principal place of business	Dover, Delaware
Country of incorporation	United States
Ownership percentage in subsidiary	100.00%
Auris Medical Ltd. [Member]
Reporting Entity (Details) [Line Items]
Name of subsidiary	Auris Medical Ltd.
Principal place of business	Dublin
Country of incorporation	Ireland
Ownership percentage in subsidiary	100.00%
Zilentin AG [Member]
Reporting Entity (Details) [Line Items]
Name of subsidiary	Zilentin AG
Principal place of business	Zug
Country of incorporation	Switzerland
Ownership percentage in subsidiary	100.00%
Auris Medical Pty Ltd [Member]
Reporting Entity (Details) [Line Items]
Name of subsidiary	Auris Medical Pty Ltd
Principal place of business	Collingwood
Country of incorporation	Australia
Ownership percentage in subsidiary	100.00%
Altamira Medica AG [Member]
Reporting Entity (Details) [Line Items]
Name of subsidiary	Altamira Medica AG
Principal place of business	Zug
Country of incorporation	Switzerland
Ownership percentage in subsidiary	100.00%
Switzerland [Member] | Auris Medical AG [Member]
Reporting Entity (Details) [Line Items]
Share capital of subsidiary	SFr 2,500,000
Switzerland [Member] | Otolanum AG [Member]
Reporting Entity (Details) [Line Items]
Share capital of subsidiary	100,000
Switzerland [Member] | Zilentin AG [Member]
Reporting Entity (Details) [Line Items]
Share capital of subsidiary	100,000
Switzerland [Member] | Altamira Medica AG [Member]
Reporting Entity (Details) [Line Items]
Share capital of subsidiary	SFr 3,000,000
USD [member] | Altamira Therapeutics, Inc [Member]
Reporting Entity (Details) [Line Items]
Share capital of subsidiary | $		$ 100
EUR [Member] | Auris Medical Ltd. [Member]
Reporting Entity (Details) [Line Items]
Share capital of subsidiary | €			€ 100
Australia [Member] | Auris Medical Pty Ltd [Member]
Reporting Entity (Details) [Line Items]
Share capital of subsidiary | $				$ 100

v3.23.2

Basis of Preparation Statement of Compliance (Details) $ in Millions	1 Months Ended	6 Months Ended
	Oct. 21, 2022 USD ($)	Jun. 30, 2022 CHF (SFr)	Jun. 30, 2022 USD ($)	Dec. 31, 2021 CHF (SFr)
Basis of Preparation Statement of Compliance (Details) [Line Items]
Intangible asset (in Francs) | SFr		SFr 15,851,501		SFr 14,314,877
Agreement description		The Company believes its cash of CHF 372,647 at June 30, 2022, together with revenues from Bentrio product sales, the receipt of grants, proceeds from the issuance of Common Shares under the A.G.P. Sales Agreement and the 2020 Commitment Purchase Agreement of USD 2.2 million up to the reporting date as well as from further issuances under the A.G.P. Sales Agreement and the 2022 Commitment Purchase Agreement, and the USD 2.2 million upfront payment it expects to receive under the Share Purchase Agreement and Option Agreement, dated October 19, 2022 and amended on November 23, 2022 (as discussed below), will fund the Company’s projected operations through the fourth quarter of 2022. We expect that our funding requirements for operations and financial obligations until the end of 2023 will amount to CHF 22.0 to 25.0 million and to CHF 17.0 to 20 million if the convertible loan provided by FiveT will be converted into Common Shares.	The Company believes its cash of CHF 372,647 at June 30, 2022, together with revenues from Bentrio product sales, the receipt of grants, proceeds from the issuance of Common Shares under the A.G.P. Sales Agreement and the 2020 Commitment Purchase Agreement of USD 2.2 million up to the reporting date as well as from further issuances under the A.G.P. Sales Agreement and the 2022 Commitment Purchase Agreement, and the USD 2.2 million upfront payment it expects to receive under the Share Purchase Agreement and Option Agreement, dated October 19, 2022 and amended on November 23, 2022 (as discussed below), will fund the Company’s projected operations through the fourth quarter of 2022. We expect that our funding requirements for operations and financial obligations until the end of 2023 will amount to CHF 22.0 to 25.0 million and to CHF 17.0 to 20 million if the convertible loan provided by FiveT will be converted into Common Shares.
Sale percentage of share capital	90.00%
Cash consideration	$ 1.0
Total, cash consideration	2.0
Additional Subsidiaries upfront payment	25.0
Upfront payment increasing per month amount	$ 1.0
Unconverted outstanding loan amount		SFr 4,701,906	$ 25.0
Option to purchase percentage		90.00%	90.00%
Capitalized development costs (in Francs) | SFr		SFr 12,000,000
Eexclusive licensing		SFr 900,000	$ 1.0
Bottom of range [member]
Basis of Preparation Statement of Compliance (Details) [Line Items]
Not yet received initial amount			2.0
Top of range [member]
Basis of Preparation Statement of Compliance (Details) [Line Items]
Not yet received initial amount			$ 2.2

v3.23.2

Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated balance sheet	Jun. 30, 2022 USD ($)
As Reported [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated balance sheet [Line Items]
Deferred income
Total non-current liabilities	1,014,188
Total liabilities	10,804,712
Accumulated deficit	(182,602,921)
Total shareholders’ equity attributable to owners of the company	7,675,164
Adjustment [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated balance sheet [Line Items]
Deferred income	932,200
Total non-current liabilities	932,200
Total liabilities	932,200
Accumulated deficit	(932,200)
Total shareholders’ equity attributable to owners of the company	(932,200)
Adjusted [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated balance sheet [Line Items]
Deferred income	932,200
Total non-current liabilities	1,946,388
Total liabilities	11,736,912
Accumulated deficit	(183,535,121)
Total shareholders’ equity attributable to owners of the company	$ 6,742,964

v3.23.2

Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss - USD ($)	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
As Reported [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss [Line Items]
Revenue	$ 1,222,998
Gross profit	30,766
Operating loss	(7,483,561)	$ (17,099,793)
Loss before tax	(7,352,403)	(17,368,546)
Net loss attributable of owners of the Company	(7,306,318)	$ (17,390,166)
Total comprehensive loss attributable to owners of the Company	$ (7,160,269)
Basic loss per share (in Dollars per share)	$ (9.43)	$ (26.26)
Adjustment [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss [Line Items]
Revenue	$ (932,200)
Gross profit	(932,200)
Operating loss	(932,200)	$ 331,723
Loss before tax	(932,200)	331,723
Net loss attributable of owners of the Company	(932,200)	$ 331,723
Total comprehensive loss attributable to owners of the Company	$ (932,200)
Basic loss per share (in Dollars per share)	$ (1.2)	$ 0.5
Adjusted [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss [Line Items]
Revenue	$ 290,798
Gross profit	(901,434)
Operating loss	(8,415,761)
Loss before tax	(8,284,603)
Net loss attributable of owners of the Company	(8,238,518)
Total comprehensive loss attributable to owners of the Company	$ (8,092,469)
Basic loss per share (in Dollars per share)	$ (10.63)

v3.23.2

Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss (Parentheticals) - $ / shares	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
As Reported [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss (Parentheticals) [Line Items]
Diluted loss per share	$ (9.43)	$ (26.26)
Adjustment [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss (Parentheticals) [Line Items]
Diluted loss per share	(1.20)	$ 0.50
Adjusted [Member]
Basis of Preparation Statement of Compliance (Details) - Schedule of adjusted consolidated statement of profit or loss and other comprehensive loss (Parentheticals) [Line Items]
Diluted loss per share	$ (10.63)

v3.23.2

Taxation (Details) - Schedule of income tax expense - CHF (SFr)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Schedule Of Income Tax Expense Abstract
Current income tax expense	SFr (1,231)
Deferred income tax gain	47,316	10,642
Total income tax (expense)/gain	SFr 46,085	SFr 10,642

v3.23.2

Taxation (Details) - Schedule of deferred income tax liabilities or to deferred income tax assets - CHF (SFr)	Jun. 30, 2022	Dec. 31, 2021
Deferred Tax liabilities
Total	SFr (128,774)	SFr (174,363)
Deferred Tax assets
Total	32,775	31,879
Deferred Tax, net	(95,999)	(142,484)
Net operation loss (NOL) [Member]
Deferred Tax assets
Total	32,775	31,879
Intangible assets [Member]
Deferred Tax liabilities
Total	(47,590)	(51,914)
Other Receivables [Member]
Deferred Tax liabilities
Total	SFr (81,184)	SFr (122,449)

v3.23.2

Capital and Reserves (Details)				1 Months Ended			6 Months Ended			12 Months Ended
	Jun. 01, 2021 USD ($) shares	Dec. 01, 2020	May 15, 2019 shares	Apr. 23, 2020	Nov. 30, 2018 USD ($)	Jan. 30, 2018 shares	Jun. 30, 2022 CHF (SFr) SFr / shares shares	Jun. 30, 2022 USD ($) shares	Jun. 30, 2021 CHF (SFr) SFr / shares shares	Dec. 31, 2021 CHF (SFr)	Jun. 30, 2021 USD ($) shares
Capital and Reserves (Details) [Line Items]
Upfront acquisition price (in Dollars) | $	$ 2,500,000
Non registered common shares	38,218
Reference price (in Dollars) | $	$ 65.4
Additional non registered price	459
Additional reference price (in Dollars) | $	$ 30,000
Description of public offering		On March 4, 2021, the remaining convertible loan by FiveT in the amount of CHF 604,545 plus accumulated interests of CHF 40,268 was converted into 25,841 common shares at a conversion price of USD 27.00.
Purchase agreement, description				On April 23, 2020, the Company entered into a purchase agreement and a Registration Rights Agreement with Lincoln Park Capital Fund, LLC (the “2020 Commitment Purchase Agreement”). Pursuant to the 2020 Commitment Purchase Agreement, LPC agreed to subscribe for up to USD 10,000,000 of our common shares over the 30-month term of the 2020 Commitment Purchase Agreement. Through June 30, 2022, we issued a total of 165,000 of our common shares to LPC for an aggregate amount of USD 2,806,605 under the 2020 Commitment Purchase Agreement. During the six months ended June 30, 2022, we issued 105,000 of our common shares to LPC for an aggregate amount of USD 1,698,450 under the 2020 Commitment Purchase Agreement, and as of the date of this report, we have issued a total of 325,000 of our common shares to LPC for an aggregate amount of USD 4,003,820 under the 2020 Commitment Purchase Agreement.
Warrants			44,872
Proceeds from issue of ordinary shares (in Dollars) | $					$ 25,000,000
Shares issued							147,166	147,166
Aggregate offering price (in Dollars) | $								$ 6,700,000
Common shares											87,931
Aggregate offering price (in Dollars) | $											$ 2,900,000
Share Capital [Member]
Capital and Reserves (Details) [Line Items]
Issued shares							853,213	853,213	682,157
Amount of stock (in Francs) | SFr							SFr 170,643		SFr 136,431
Nominal value per share (in Francs per share) | SFr / shares							SFr 0.2		SFr 0.2
LPC Agreement [Member]
Capital and Reserves (Details) [Line Items]
Purchase agreement, description					On November 30, 2018, as amended on April 5, 2019 the Company entered into a sales agreement, as amended (the “A.G.P. Sales Agreement”) with A.G.P./Alliance Global Partners (“A.G.P.”).
AGP Sales Agreement [Member]
Capital and Reserves (Details) [Line Items]
Shares issued							228,666	228,666
Aggregate offering price (in Dollars) | $								$ 7,800,000
Warrants [Member]
Capital and Reserves (Details) [Line Items]
Warrants exercisable shares						459
Changes in fair value of warrants issued (in Francs) | SFr							SFr 1,233			SFr 1,233

v3.23.2

Capital and Reserves (Details) - Schedule of Issued Share Capital - shares	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Schedule Of Issued Share Capital Abstract
Beginning balance	748,213	570,858
Common shares issued	105,000	111,299
Ending balance	853,213	682,157

v3.23.2

Loans (Details) $ in Millions				6 Months Ended
	Feb. 08, 2022 CHF (SFr)	Feb. 04, 2022 CHF (SFr)	Mar. 26, 2020 CHF (SFr)	Jun. 30, 2022 CHF (SFr)	Jun. 30, 2022 USD ($)	Sep. 09, 2022 CHF (SFr)
Description Of Accounting Policy For Loans And Receivables Text Block Abstract
Loan amount		SFr 5,000,000				SFr 600,000
Loan bears interest rate		10.00%
Loan agreement, description		The Company may prepay all or part of the Loan after six months after the Disbursement Date; provided that the Company will pay an amount equal to 130% of the desired prepayment amount. The Lender has the right to convert all or part of the Loan, including accrued and unpaid interest, at its option, into common shares, subject to the limitation that the Lender own no more than 9.99% of the common shares at any time. The conversion price of the Loan into common shares is USD 38.916, which corresponds to 150% of USD 25.944 (the trading volume weighted average price, the “VWAP”, per common share on the NASDAQ stock exchange on the Disbursement Date), converted into Swiss Francs at the midpoint of the interbank exchange rate shown by UBS on the day of receipt of the conversion notice at 4:00 pm Central European Time. The conversion price shall be lowered in the event that the Company raises equity before the maturity date of the Loan through a public or private offering of common shares at an issue price that is at least 10 (ten)  % below the VWAP (the “New Issue”), according to the formula set forth in the Loan Agreement (the “Adjustment”).
Unconverted outstanding loan amount				SFr 4,701,906	$ 25
Fair value of the embedded derivatives amount				SFr 284
Initial recognition	SFr 449,898
Fair value measurement of embedded derivatives	449,614
Effective interest expenses and transaction costs	SFr 359,068
Loan eligible amount			SFr 50,000
Loan interest free repaid term			5 years

v3.23.2

Employee Benefits (Details)	6 Months Ended
	Jun. 30, 2022 CHF (SFr) shares	Jun. 30, 2022 $ / shares	Jun. 30, 2021 CHF (SFr) shares	Jun. 30, 2021 $ / shares
Disclosure Of Employee Benefits Text Block Abstract
Stock options	SFr 180,808		SFr 159,487
Share based compensation expense			810,252
Future share grant contingent			SFr 360,112
Granted options (in Shares) | shares	27,861		6,862
Equity incentive plans (in Dollars per share) | $ / shares		$ 20.8		$ 70.2

v3.23.2

Employee Benefits (Details) - Schedule of Employee Benefits - CHF (SFr)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Schedule Of Employee Benefits Abstract
Salaries	SFr 1,439,578	SFr 812,158
Pension costs	132,784	66,002
Share based compensation expense	180,808	969,739
Other employee costs and social benefits	157,358	257,108
Total employee benefits	SFr 1,910,528	SFr 2,105,007

v3.23.2

Write-down of Inventories (Details)	6 Months Ended
	Jun. 30, 2022 CHF (SFr)
Writedown Of Inventories Abstract
Write down finished goods inventories	SFr 764,844

v3.23.2

Revision of Prior Period Financial Statements (Details) - Non-adjusting events after reporting period [member]	1 Months Ended
	Oct. 25, 2022 CHF (SFr)
Revision of Prior Period Financial Statements (Details) [Line Items]
Reverse share split	SFr 1.31
revised reverse share split	SFr 1.29

v3.23.2

Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Balance Sheet	Dec. 31, 2021 USD ($)
As Reported [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Balance Sheet [Line Items]
Other receivables	$ 917,833
Prepayments	996,910
Total current assets	3,759,901
Total assets	18,838,598
Accumulated deficit	(176,018,660)
Total shareholders’ equity attributable to owners of the company	12,704,528
Total equity and liabilities	18,838,598
Adjustment [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Balance Sheet [Line Items]
Other receivables	(246,493)
Prepayments	578,216
Total current assets	331,723
Total assets	331,723
Accumulated deficit	331,723
Total shareholders’ equity attributable to owners of the company	331,723
Total equity and liabilities	331,723
As Revised [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Balance Sheet [Line Items]
Other receivables	671,340
Prepayments	1,575,126
Total current assets	4,091,624
Total assets	19,170,321
Accumulated deficit	(175,686,937)
Total shareholders’ equity attributable to owners of the company	13,036,251
Total equity and liabilities	$ 19,170,321

v3.23.2

Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss - USD ($)	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
As Reported [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss [Line Items]
Other income		$ 460,710
Research and development		(8,939,037)
Total operating expenses		(15,137,338)
Operating loss	$ (7,483,561)	(17,099,793)
Loss before tax	(7,352,403)	(17,368,546)
Net loss attributable of owners of the Company	$ (7,306,318)	(17,390,166)
Total comprehensive loss attributable to owners of the Company		$ (17,124,410)
Basic and diluted loss per share (in Dollars per share)	$ (9.43)	$ (26.26)
Adjustment [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss [Line Items]
Other income		$ (246,493)
Research and development		578,216
Total operating expenses		331,723
Operating loss	$ (932,200)	331,723
Loss before tax	(932,200)	331,723
Net loss attributable of owners of the Company	$ (932,200)	331,723
Total comprehensive loss attributable to owners of the Company		$ 331,723
Basic and diluted loss per share (in Dollars per share)	$ (1.2)	$ 0.5
As Revised [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss [Line Items]
Other income		$ 214,217
Research and development		(8,360,821)
Total operating expenses		(14,805,615)
Operating loss		(16,768,070)
Loss before tax		(17,036,823)
Net loss attributable of owners of the Company		(17,058,443)
Total comprehensive loss attributable to owners of the Company		$ (16,792,687)
Basic and diluted loss per share (in Dollars per share)		$ (25.76)

v3.23.2

Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss (Parentheticals) - $ / shares	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
As Reported [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss (Parentheticals) [Line Items]
Basic and diluted loss per share	$ (9.43)	$ (26.26)
Adjustment [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss (Parentheticals) [Line Items]
Basic and diluted loss per share	$ (1.20)	0.50
As Revised [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Revised Consolidated Statement of Profit or Loss and Other Comprehensive Loss (Parentheticals) [Line Items]
Basic and diluted loss per share		$ (25.76)

v3.23.2

Revision of Prior Period Financial Statements (Details) - Schedule of Consolidated Statement of Cash Flows	12 Months Ended
	Dec. 31, 2021 USD ($)
As Reported [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Consolidated Statement of Cash Flows [Line Items]
Net loss	$ (17,390,166)
Changes in:
Trade and other receivables	(586,612)
Prepayments	(719,321)
Cash used in operating activities	(13,627,738)
Adjustment [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Consolidated Statement of Cash Flows [Line Items]
Net loss	331,723
Changes in:
Trade and other receivables	246,493
Prepayments	(578,216)
Cash used in operating activities
As Revised [Member]
Revision of Prior Period Financial Statements (Details) - Schedule of Consolidated Statement of Cash Flows [Line Items]
Net loss	(17,058,443)
Changes in:
Trade and other receivables	(340,119)
Prepayments	(1,297,537)
Cash used in operating activities	$ (13,672,738)

v3.23.2

Loss Per Share (Details) - shares	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Loss Per Share (Details) [Line Items]
Average number of options outstanding	74,996	54,025
Stock Options [Member]
Loss Per Share (Details) [Line Items]
Options outstanding	94,337

v3.23.2

Loss Per Share (Details) - Schedule of loss per share - CHF (SFr)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Loss Per Share [Abstract]
Loss attributable to owners of the Company	SFr (8,238,518)	SFr (6,754,579)
Weighted average number of shares outstanding	774,898	622,741
Basic loss per share	SFr (10.63)	SFr (10.85)

v3.23.2

Loss Per Share (Details) - Schedule of loss per share (Parentheticals)	6 Months Ended
	Jun. 30, 2022 SFr / shares	Jun. 30, 2021 SFr / shares	Jun. 30, 2021 $ / shares
Loss Per Share [Abstract]
Diluted loss per share | (per share)	SFr (10.63)	SFr (10.85)	$ (10.85)

v3.23.2

Events After the Reporting Period (Details) SFr / shares in Units, $ in Millions				1 Months Ended		6 Months Ended
	Nov. 14, 2022	Oct. 21, 2022 USD ($)	Sep. 09, 2022 CHF (SFr) SFr / shares shares	Oct. 26, 2022 CHF (SFr)	Oct. 25, 2022 shares	Jun. 30, 2022 CHF (SFr)	Feb. 04, 2022 CHF (SFr)
Events After the Reporting Period [Abstract]
Aggregate amount (in Francs) | SFr			SFr 600,000				SFr 5,000,000
Interest rate			5.00%
Maturity date			March 31, 2023
Aggregate common shares (in Shares) | shares			41,667
Exercise price, per share (in Francs per share) | SFr / shares			SFr 7.2
Share capital percentage		90.00%
Cash consideration		$ 1
Additional subsidiaries		25
Revenues from royalties		55
Upfront payment		$ 1
Divestiture of inner ear therapeutic assets description						Due to a delay in the closing of the Zilentin Transaction, the Company and the Buyer agreed on November 23, 2022 to amend their agreement, extending the Closing Date to December 15, 2022 at the latest, increasing the share capital of Zilentin AG to be sold under the transaction from 90 to 100% and raising the amount of the initial payment for the purchase of Zilentin and for the option to purchase the Additional Subsidiaries from USD 2 million to USD 2.2 million.
Capitalized development costs (in Francs) | SFr						SFr 12,000,000
Share split of common shares (in Shares) | shares					1,074,713
Nominal value (in Francs) | SFr				SFr 0.2
Commitment purchase agreement description	On November 14, 2022, we entered into a term sheet with LPC for the conclusion of a purchase agreement under which LPC would commit to subscribe for up to USD 10,000,000 of our common shares over the 24-month term of the purchase agreement. The Company and LPC endeavor to enter into a mutually acceptable purchase agreement (the “2022 Commitment Purchase Agreement”) and related documentation within ten business days from the date of the term sheet. The Company shall pay to LPC upon signing of the 2022 Commitment Purchase Agreement a commitment fee at its sole discretion of either (i) USD 250,000 in cash or (ii) issue 50,000 Common Shares and prepare and file as soon as practicable a resale registration statement registering the shares issuable under the 2022 Commitment Purchase Agreement.

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