| Explanation of Responses: |
| (1) | Helix Holdings LLC is the record holder of these securities. Bihua Chen is the manager of Helix Holdings LLC and has voting and investment discretion with respect to the securities held of record by Helix Holdings LLC. Ms. Chen disclaims any beneficial ownership of the securities held by Helix Holdings LLC other than to the extent of any pecuniary interest she may have therein, directly or indirectly. |
| (2) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $36.20 to 37.00 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (3) | Various funds (the "Cormorant Funds") managed by Cormorant Asset Management, LP are the record holders of these securities. Bihua Chen is the founder and managing member of Cormorant Asset Management, LP and has voting and investment discretion with respect to the ordinary shares held by the Cormorant Funds. Ms. Chen disclaims any beneficial ownership of such securities other than to the extent of any pecuniary interest she may have therein, directly or indirectly. |
| (4) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $37.50 to $38.49 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (5) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $38.51 to $39.50 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (6) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $39.51 to $40.50 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (7) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $40.52 to $41.51 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (8) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $41.70 to $42.69 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (9) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $42.80 to $43.79 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (10) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $43.80 to $44.79 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (11) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $44.80 to $45.00 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (12) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $48.27 to $49.26 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (13) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $49.27 to $50.26 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (14) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $50.27 to $51.24 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (15) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $51.28 to $52.25 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (16) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $52.31 to $53.29 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (17) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $53.31 to $54.30 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (18) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $54.31 to $55.30 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (19) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $55.32 to $56.24 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (20) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $56.40 to $57.31 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (21) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $57.48 to $58.00 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (22) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $58.49 to $59.45 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (23) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $59.57 to $60.41 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (24) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $62.01 to $62.50 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (25) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $63.17 to $64.11 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (26) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $64.24 to $64.58 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |
| (27) | Represents ordinary shares purchased in a series of open market transactions on the transaction date at prices ranging from $72.41 to $72.50 per ordinary share. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of ordinary shares purchased at each price. |