Studies Validate Advantages of Administering Drugs to Pets via IntelGenx’s VetaFilm® Platform
05 Febrero 2024 - 7:00AM
IntelGenx Corp. (TSX:IGX) (OTCQB:IGXT) (the "Company" or
"IntelGenx") today announced positive results from a
proof-of-concept (“POC”) study to assess the palatability,
owner-perceived acceptability, and ease of repeated administration
of IntelGenx’s VetaFilm® platform in healthy dogs and cats. The POC
study was conducted through a research collaboration with the
University Prince Edward Island (“UPEI”), one of North America’s
leading veterinary universities.
The reliable administration of medications to
dogs and cats is a concern for many owners and veterinarians. There
are few prescribed medications that dogs and cats will eagerly
accept. Forced administration of capsules, tablets and liquids may
be stressful for both the pet and its owner(s). Additionally, many
owners report that medicating their pet becomes more difficult with
each dose, often leading to decreased owner compliance, missed
doses and potentially treatment failures. IntelGenx’s
VetaFilm®-based fast dissolving oral films (“VetaFilm® FDOFs”)
present a new and potentially superior way to medicate companion
animals.
The research collaboration with UPEI evaluated:
(1) the acceptance rate of various VetaFilm® placebo formulations
in dogs and cats at first exposure; (2) preference between flavours
of VetaFilm® placebo formulations in dogs and cats; (3) changes in
acceptance rates over longer periods; and (4), owner perception of
ease of administration, acceptance and other behaviors associated
with VetaFilm® placebo formulations.
Key findings included:
- The VetaFilm®
FDOFs were well accepted and well tolerated by both dogs and
cats;
- Repeated dosing
(twice a day for one week) showed high continued acceptance rates
in both species with little or no effect of time on the continued
acceptance of the VetaFilm® FDOFs;
- Overall, 100% of
dog owners and 67% of cat owners felt that administration of the
VetaFilm® FDOFs was “very easy” or “easy”; and
- 95% of dog
owners and 82% of cat owners identified VetaFilm® FDOFs as the
preferred method of medication administration.
“These results come at an opportune time as we
continue to expand our Animal Health business and work toward
establishing our proprietary VetaFilm® drug delivery platform as a
standard administration method for dogs and cats,” commented Dwight
Gorham, IntelGenx’s CEO. “We would like to thank the esteemed
clinicians and researchers at UPEI, the many pet owners, and of
course the cherished dogs and cats that participated in these
studies.”
About
VetaFilm®
In addition to increased compliance and
convenience, there are a number of clinical advantages with
administering drugs to pets via IntelGenx’s proprietary VetaFilm®
platform. Studies have demonstrated that, when administering
capsules and tablets to dogs and cats, there can be a delay in
reaching the stomach. But more importantly, certain medication can
cause significant mucosal damage when allowed to sit in the
esophagus for a prolonged period, which is often the case when
‘dry-pilling’. Finally, from a pharmacokinetic standpoint, buccal
absorption may decrease the overall amount of drug required as
first pass metabolism would be largely avoided.
About IntelGenx
IntelGenx is a leading drug delivery company
focused on the development and manufacturing of pharmaceutical
films.
IntelGenx’s superior film technologies,
including VersaFilm®, DisinteQ™, VetaFilm® and transdermal
VevaDerm™, allow for next generation pharmaceutical products that
address unmet medical needs. IntelGenx’s innovative product
pipeline offers significant benefits to patients and physicians for
many therapeutic conditions.
IntelGenx's highly skilled team provides
comprehensive pharmaceuticals services to pharmaceutical partners,
including R&D, analytical method development, clinical
monitoring, IP and regulatory services. IntelGenx's
state-of-the-art manufacturing facility offers full service by
providing lab-scale to pilot- and commercial-scale production. For
more information, visit www.intelgenx.com.
Forward-Looking Information and
Statements
This document may contain forward-looking
information about IntelGenx's operating results and business
prospects that involve substantial risks and uncertainties.
Statements that are not purely historical are forward-looking
statements within the meaning of Section 21E of the Securities
Exchange Act of 1934, as amended, and Section 27A of the Securities
Act of 1933, as amended. These statements include, but are not
limited to, statements about IntelGenx's plans, objectives,
expectations, strategies, intentions or other characterizations of
future events or circumstances and are generally identified by the
words "may," "expects," "anticipates," "intends," "plans,"
"believes," "seeks," "estimates," "could," "would," and similar
expressions. All forward looking statements are expressly qualified
in their entirety by this cautionary statement. Because these
forward-looking statements are subject to a number of risks and
uncertainties, IntelGenx's actual results could differ materially
from those expressed or implied by these forward-looking
statements. Factors that could cause or contribute to such
differences include, but are not limited to, those discussed under
the heading "Risk Factors" in IntelGenx's annual report on Form
10-K, filed with the United States Securities and Exchange
Commission and available at www.sec.gov, and also filed with
Canadian securities regulatory authorities at www.sedarplus.com.
IntelGenx assumes no obligation to update any such forward-looking
statements.
Source: IntelGenx Technologies Corp.
For IntelGenx:
Stephen KilmerInvestor Relations(647)
872-4849stephen@kilmerlucas.com
Or
Andre Godin, CPA, CAPresident and CFOIntelGenx Corp.(514)
331-7440 ext 203andre@intelgenx.com
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