DOW JONES NEWSWIRES 
 

Avigen Inc. (AVGN) said it has stopped takeover talks and warned the small biopharmaceutical concern would develop a liquidation plan if a slate of candidates for the board from suitor Biotechnology Value Fund LP aren't elected at Friday's special shareholders meeting.

Avigen's board also declined to take a position on BVF's sweetened $35.7 million takeover offer while saying several executives, including President and Chief Executive Kenneth Chahine, are no longer with the company. It said they left as part of a headcount reduction, which follows a 27-position, or 70%, slashing of its work force late last year.

Shares were flat at $1.16 in recent trading, slightly below BVF's latest offer of $1.20. On Thursday, Avigen's board noted the offer is roughly the same as the company's net cash value minus wind-down costs but doesn't reflect the value of other assets, including its nerve-pain and addiction drug under development and $6 million in upcoming payments from Genzyme Corp. (GENZ).

Fellow biopharma concern MediciNova Inc. (MNOV) has been seeking due-diligence access from Avigen, as it, too, is interested in potentially buying the company. But so far the requests have been blocked.

BVF, which owns nearly 30% of Avigen's stock, began agitating for change in October after a trial of a drug to treat multiple sclerosis failed to meet its objectives. In seeking to sack Avigen's board, the investment fund said it has gotten management and the board to cut costs and shed "programs that they do not have the necessary expertise to develop."

Since the company has stopped takeover talks, Avigen said most employees that were taking part in that effort, including former CEO Chahine, were no longer needed. Chief Financial Officer Andrew Sauter will take over from Chahine.

Many small biotech companies are gasping for cash as many can no longer find investors to fund continued drug development. Nearly a dozen have declared bankruptcy in the past four months, while nearly one-third of publicly traded biotechs have less than six months of cash left, according to Burrill & Co., a venture-capital concern in San Francisco that follows the industry.

-By Tess Stynes, Dow Jones Newswires; 201-938-2473; tess.stynes@dowjones.com