USA News Group
Commentary
Issued on behalf of Oncolytics Biotech
Inc.
VANCOUVER, BC, May 3, 2024
/CNW/ -- According to a "highly troubling" new study, the rising
number of cancer cases in young people is being attributed to
"accelerated aging." Further alarm is being spread by the United
Nations, whose health authorities are predicting global cancer
cases to rise around 77% by 2050, with richer countries expected to
have the greatest absolute increase in cancer, with an additional
4.8 million new cases predicted in 2050. With the global cancer
immunotherapy market projected by analysts at Custom Market
Insights to reach US$314.4
billion by 2032, growing at a 7.2% CAGR, the biotech sector
continues to make significant developments in cancer treatment and
diagnostics, with recent updates coming from Oncolytics
Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Celcuity Inc.
(NASDAQ: CELC), Olema Pharmaceuticals, Inc. (NASDAQ: OLMA),
Bio-Rad Laboratories, Inc. (NYSE: BIO), and AstraZeneca
PLC (NASDAQ: AZN).
Since receiving Fast Track Designation from the FDA
in late 2022 for its leading cancer treatment, pelareorep, in the
treatment of pancreatic cancer, Oncolytics Biotech Inc.
(NASDAQ: ONCY) (TSX: ONC) has maintained strong progress. The
company recently announced that it has requested a Type C
meeting with the FDA to discuss an upcoming
registration-enabling trial of pelareorep for treating HR+/HER2-
metastatic breast cancer (mBC) patients.
"A key focus for Oncolytics in 2024 is defining the
regulatory path for pelareorep in breast cancer treatment," said
Matt Coffey, President and CEO of
Oncolytics. "We are optimistic that pelareorep, in
combination with paclitaxel, could significantly enhance clinical
outcomes for patients with HR+/HER2- metastatic breast cancer. Our
position is strengthened by encouraging data from two randomized
studies (BRACELET-1 and IND-213) and the AWARE-1 study, paving the
way for the next phase of pelareorep's development and
registration."
Dr. Coffey has noted that ongoing collaborations with clinical
collaborators have been key to preparing a comprehensive and
convincing briefing document. Oncolytics Biotech requested
to meet with the FDA in Q2 2024 to finalize the
registrational trial design and objectives for using pelareorep to
treat metastatic breast cancer. This meeting is essential for
moving this promising treatment closer to patient use. With
forthcoming survival data from its BRACELET-1 study and productive
discussions with the FDA, Oncolytics is hopeful that
2024 will mark a significant milestone for the company and its
stakeholders.
"The data from the randomized BRACELET-1 trial showcased
compelling results for the pelareorep/paclitaxel combination
therapy in HR+/HER2- metastatic breast cancer patients, with a
nearly tripled confirmed response rate, a 50% improvement in median
progression-free survival, and a hazard ratio of 0.29 compared to
the paclitaxel alone control," said Thomas
Heineman, M.D., Ph.D., Chief Medical Officer at
Oncolytics. "Importantly, these data support the
statistically significant near doubling of median overall survival
in another randomized phase 2 study, IND-213, which also evaluated
pelareorep and paclitaxel in HR+/HER2- metastatic breast cancer
patients."
Another company that's developing targeted therapies for
multiple cancer indications is Celcuity Inc. (NASDAQ: CELC).
Within its latest Q4/FY 2023 financial results and corporate
update, Celcuity spoke of how it had dosed its first
patient in a Phase 1b/2 trial
evaluating gedatolisib in combination with darolutamide for the
treatment of metastatic castration-resistant prostate cancer.
"We are excited to begin enrolling patients in our 201 trial and
advancing towards our ultimate goal of providing a transformative
therapeutic option for patients with prostate cancer,"
said Igor Gorbatchevsky, M.D., Chief Medical Officer of
Celcuity. "A significant unmet need remains for patients
with metastatic castration-resistant prostate cancer who have
become resistant to a next generation androgen receptor
inhibitor."
Late last year, Celcuity also presented preclinical
data on the therapeutic effects of gedatolisib in breast
cancer models at the 2023 San Antonio Breast Cancer Symposium. As
its flagship asset, Celcuity's gedatolisib is a potent,
reversible dual inhibitor that selectively targets all Class I PI3K
isoforms and mTOR.
In the process of becoming an impressive comeback story,
Olema Pharmaceuticals, Inc. (NASDAQ: OLMA) has moved from
making job cuts in 2023 to moving forward with pivotal drug
studies in 2024. Recently in March, Olema announced the
publication of data highlighting its proprietary treatment
palazestrant's (OP-1250) ability to inhibit wild-type and mutant
ER+ breast cancer both as monotherapy and in combination with
CDK4/6 inhibitors through a paper titled "Palazestrant (OP-1250), a
Complete Estrogen Receptor Antagonist, Inhibits Wild-type and
Mutant ER-positive Breast Cancer Models as Monotherapy and in
Combination."
"The research described in this paper reviews the deliberate
design and processes used in discovering and optimizing
palazestrant as a molecule purpose-built to address a crucial unmet
need in the treatment of women's cancers, and we are delighted that
Molecular Cancer Therapeutics has featured our work," said
David C. Myles, Ph.D.,
Olema's Chief Discovery and Non-Clinical Development
Officer. "What's even more exciting is to see how faithfully the
pre-clinical research predicted the behavior of palazestrant now
that it is in late-stage clinical development. We saw the potential
then, as told in the paper, and we believe that every day brings us
closer to having a real impact transforming the treatment paradigm
for women with cancer."
Helping to potentially detect breast cancer more easily,
Bio-Rad Laboratories, Inc. (NYSE: BIO) recently
launched its first ultrasensitive multiplexed digital PCR
assay for breast cancer mutation detection in clinical research.
The newly launched ddPLEX ESR1 Mutation Detection Kit assay expands
Bio-Rad's Droplet Digital PCR (ddPCR™) offering for the
oncology market, where highly sensitive and multiplexed mutation
detection assays aid translational research, therapy selection, and
disease monitoring.
"With the ddPLEX ESR1 Mutation Detection Kit, our customers can
achieve new levels of sensitivity and multiplexing without
compromising throughput," said Stephen
Kulisch, Vice President of Marketing for Bio-Rad's
Digital Biology Group. "This launch reflects our ongoing menu
expansion in oncology and our commitment to providing oncology
researchers with technologies that enable everything from biomarker
discovery to clinical trials that support improvements in patient
monitoring."
Shortly after the launch, Bio-Rad partnered with
Alleghany Health Network (AHN) to advance clinical evidence
for monitoring solid tumor cancers using the ddPCR technology. The
collaboration will use ddPCR technology for molecular residual
disease (MRD) monitoring of patients across a range of solid tumor
types.
Even more promising breast cancer data has come out
recently from AstraZeneca PLC (NASDAQ: AZN) and partners
Daiichi Sankyo for their jointly developed antibody drug
conjugate Enhertu (trastuzumab deruxtecan), from their phase 3
breast cancer trial. Results from the DESTINY-Breast06
trial demonstrated a statistically significant and clinically
meaningful improvement in progression-free survival (PFS) compared
to standard-of-care chemotherapy in the primary trial population of
patients with HR-positive, HER2-low metastatic breast cancer
following one or more lines of endocrine therapy.
"DESTINY-Breast06 shows that ENHERTU could become a new standard
of care for patients with HER2-low and HER2-ultralow metastatic
breast cancer following one or more lines of endocrine therapy,"
said Susan Galbraith, Executive Vice
President, Oncology R&D, AstraZeneca. "These data
underscore the potential for treatment with ENHERTU across the
spectrum of HR-positive breast cancer, further redefining the
treatment of metastatic breast cancer."
Article Source:
https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/
USA NEWS
GROUP
info@usanewsgroup.com
(604) 265-2873
DISCLAIMER: Nothing in this publication should be
considered as personalized financial advice. We are not licensed
under securities laws to address your particular financial
situation. No communication by our employees to you should be
deemed as personalized financial advice. Please consult a licensed
financial advisor before making any investment decision. This is a
paid advertisement and is neither an offer nor recommendation to
buy or sell any security. We hold no investment licenses and are
thus neither licensed nor qualified to provide investment advice.
The content in this report or email is not provided to any
individual with a view toward their individual circumstances.
USA News Group is a wholly-owned
subsidiary of Market IQ Media Group, Inc. ("MIQ"). MIQ has been
paid a fee for Oncolytics Biotech Inc. advertising and digital
media from the company directly. There may be 3rd parties who may
have shares of Oncolytics Biotech Inc., and may liquidate their
shares which could have a negative effect on the price of the
stock. This compensation constitutes a conflict of interest as to
our ability to remain objective in our communication regarding the
profiled company. Because of this conflict, individuals are
strongly encouraged to not use this publication as the basis for
any investment decision. The owner/operator of MIQ own shares of
Oncolytics Biotech Inc. which were purchased in the open market,
and reserve the right to buy and sell, and will buy and sell shares
of Oncolytics Biotech Inc. at any time without any further notice
commencing immediately and ongoing. We also expect further
compensation as an ongoing digital media effort to increase
visibility for the company, no further notice will be given, but
let this disclaimer serve as notice that all material, including
this article, which is disseminated by MIQ has been approved by
Oncolytics Biotech Inc.; this is a paid advertisement, we currently
own shares of Oncolytics Biotech Inc. and will buy and sell shares
of the company in the open market, or through private placements,
and/or other investment vehicles.
While all information is believed to be reliable, it is not
guaranteed by us to be accurate. Individuals should assume that all
information contained in our newsletter is not trustworthy unless
verified by their own independent research. Also, because events
and circumstances frequently do not occur as expected, there will
likely be differences between the any predictions and actual
results. Always consult a licensed investment professional before
making any investment decision. Be extremely careful, investing in
securities carries a high degree of risk; you may likely lose some
or all of the investment.
View original
content:https://www.prnewswire.com/news-releases/top-five-cancer-types-dominate-new-us-cases-as-biotech-sector-eyes-314b-market-by-2032-302135764.html
SOURCE USA News Group