TIDMN4P

RNS Number : 7479Z

N4 Pharma PLC

16 January 2024

16 January 2024

N4 Pharma plc

("N4 Pharma" or the "Company")

Nanogenics Update

N4 Pharma Plc (AIM: N4P), the specialist pharmaceutical company developing Nuvec(R), a novel delivery system for cancer treatments, gene therapy and vaccines, is pleased to provide an update on its subsidiary, Nanogenics Limited ("Nanogenics").

Nanogenics has signed a contract to start the formulation and sequence selection work to prepare its ECP105 product for testing in pre-clinical studies at Kings College, London.

Nanogenics' ECP105 product for the recovery of post-surgical treatment of Glaucoma contains a proprietary siRNA sequence to silence the fibrotic gene MRTF-B. Glaucoma patients who have failed to respond to medication need surgery to lower intraocular pressure which causes fibrosis at the surgery site. This fibrosis often leads to failure of the surgery and frequently patients have to undergo further surgery. ECP105 is intended for injection into the ocular cavity to switch off the gene responsible for the fibrosis. Unlike current off-label treatment using toxic chemotherapy drugs, ECP105 is intended for repeat use to prevent the need for further surgery.

The work involves creating and testing a novel formulation containing Nanogenics' proprietary siRNA sequence to undertake a proof of concept in-vivo study, to demonstrate that a single dose of its Glaucoma surgery treatment ECP105 can match the anti-fibrotic effect of current post surgical treatment using Mitomycin C, but without the cytotoxic side effects seen with this approach.

Nigel Theobald, Chief Executive Officer of the Company, commented:

"We are very excited for the potential of ECP105, which is a unique product for an unmet clinical need in the ophthalmology market. More than 75 million people worldwide are affected by Glaucoma and the total Glaucoma treatment market size in 2021 exceeded $5.5 billion and is growing. A novel product in this space alone represents a good opportunity for Nanogenics and importantly the antifibrotic siRNA sequence can also be used to investigate other fibrotic treatments for liver and lung fibrosis."

For more information please contact:

 
 N4 Pharma plc 
  Nigel Theobald, CEO                             Via N4 Pharma Investor 
  Luke Cairns, Executive Director                 Hub 
 
  Engage with us directly at N4 Pharma 
  Investor Hub                                    Sign up at investors.n4pharma.com 
 
  To hear more, visit                             https://investors.n4pharma.com/link/GyVdGr 
 SP Angel Corporate Finance LLP                 Tel: +44(0)20 3470 0470 
  Nominated Adviser and Joint Broker 
  Matthew Johnson/Kasia Brzozowska (Corporate 
  Finance) 
  Vadim Alexandre/Abigail Wayne/Rob Rees 
  (Corporate Broking) 
                                               --------------------------------------------- 
 Turner Pope Investments (TPI) Limited          Tel: +44(0)20 3657 0050 
  Joint Broker 
  Andy Thacker 
  James Pope 
                                               --------------------------------------------- 
 IFC Advisory Ltd                               Tel: +44(0)20 3934 6630 
  Financial PR 
  Graham Herring 
  Zach Cohen 
                                               ---------------------------------------------

About N4 Pharma

N4 Pharma is a specialist pharmaceutical company developing a novel delivery system for oncology, gene therapy and vaccines using its unique silica nanoparticle delivery system called Nuvec(R) and Liptide, a unique peptide/lipid delivery system via its subsidiary Nanogenics.

N4 Pharma's business model is to partner with companies developing products in these fields to use Nuvec(R) or Liptide(R) as the delivery vehicle for these products. As these products progress through pre--clinical and clinical programs, N4 Pharma will seek to receive upfront payments, milestone payments and ultimately royalty payments once products reach the market.

For further information on the Company visit www.n4pharma.com or sign up at investors.n4pharma.com .

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