UCL & Ondine Awarded GBP1 Million by UK Medical Research Council to Develop Infection Prevention Technology for Catheters
18 Enero 2011 - 8:10AM
UK Regulatory
TIDMOBP
UCL & Ondine Awarded GBP1 Million by UK Medical Research Council to Develop Infection Prevention Technology for Catheters
FOR: ONDINE BIOMEDICAL INC.
TSX, AIM SYMBOL: OBP
January 18, 2011
UCL & Ondine Awarded GBP1 Million by UK Medical Research Council to Develop Infection Prevention Technology for
Catheters
VANCOUVER, BRITISH COLUMBIA--(Marketwire - Jan. 18, 2011) - Ondine Biomedical Inc. ("Ondine" or the "Company")
(TSX:OBP)(AIM:OBP) today announced that University College London (UCL) Professors Ivan P. Parkin and Michael
Wilson and colleagues, in collaboration with Ondine, have been awarded a Medical Research Council (MRC)
Developmental Pathway Funding Scheme Award of GBP 1 million to develop a light activated antimicrobial
application for the prevention of catheter-associated infections such as urinary tract infections. This two and
one-half year project is scheduled to initiate on February 1, 2011, and represents the first of its kind for
Ondine.
This project will be managed by Professor Ivan Parkin, Head of the Department of Chemistry, UCL, and Professor
Michael Wilson, Professor of Microbiology, UCL Eastman Dental Institute ("UCLEDI"), to take existing
fundamental basic and clinical research findings towards the clinic. The stated purpose of the Award is to help
strengthen the translation of fundamental research towards patient benefit. This project is intended to enhance
the exclusive license that Ondine has with University College London on Light-Activated Antimicrobial Agents
nanoparticle conjugates and mixtures, and leverages expertise acquired by Ondine during the development of
Endowave(TM), a ventilator associated pneumonia (VAP) prevention product and MRSAid(TM), a MRSA nasal
decolonization product based on photodynamic disinfection.
"We consider this initiative to be a significant step towards the development of a major class of new medical
devices that may have the potential to reduce the number of urinary tract infections acquired in hospital,
thereby significantly reducing healthcare costs," stated Professor Ivan Parkin. "Furthermore, proof of concept
for application to urinary catheters will demonstrate a step-change in the prevention of catheter associated
infections (CAIs) and provide opportunity for the potential application of this novel approach to other
catheter types, including Cardiovascular, Intravenous & Neurovascular catheters."
Professor Michael Wilson, Professor of Microbiology, UCLEDI, and Pro-Provost for Europe at UCL, stated: "What
makes this undertaking unique is that the development work will be carried out by a multi-disciplinary team
from clinics, academia and industry consisting of chemists, bacteriologists, photobiologists, medical laser
physicists and clinicians experienced in the management of catheter-associated infections. This level of
collaboration across a number of disciplines is clearly of tremendous benefit to the project and builds on many
years of independent research, clinical experience and historic product development efforts."
"Ondine and UCL have a successful partnership that spans over ten years," said Derek Reay, Senior Business
Manager of UCLB, the business development arm of University College London. "Together, we are recognized as
global leaders in developing applications based on photodisinfection (also known as anti-microbial photodynamic
therapy). Jointly, Ondine and UCL have developed the Periowave(TM) Photodisinfection System, a light activated
antimicrobial technology for the dental market. Development of the anti-microbial catheter is a natural
extension of our past research and is an ideal collaboration between our two groups. We are therefore very
pleased for this opportunity to translate our collective expertise into a significant new product development
initiative. Combining a research approach with upfront corporate integration has proven to be very effective.
We look forward to working with Ondine on this, and future, development programs addressing antibiotic
resistant pathogens and biofilm-based infections."
"The use of light activated antimicrobials to prevent catheter associated urinary tract infections leverages
our existing product development efforts related to ventilator associated pneumonia as well as our clinical and
regulatory expertise," said Carolyn Cross, Chairman and CEO of Ondine Biomedical Inc. "Successful results from
this catheter associated infection prevention project would have immediate benefit in today's hospital
environment, and translate into sizable savings of hospital costs and improve patient outcomes since urinary
tract infections represent the largest source of healthcare-associated infections (HAIs). HAI's globally
represent tens of billions of dollars of direct and indirect costs each year as HAIs prolong hospital
treatment, increase morbidity and mortality. Photodisinfection, we believe, is ideally suited for this
application given its proven antimicrobial efficacy combined with its excellent safety profile."
About Healthcare-Associated Infections
Healthcare-associated infections (HAIs) occur when a patient acquires an infection during the course of
treatment at, or a visit to, a healthcare facility. The World Health Organization has called healthcare-
associated infections one of the biggest causes of avoidable harm and unnecessary deaths in the developed
world. Every year in the UK, hundreds of thousands patients develop HAIs that prolong hospital treatment,
increase morbidity & mortality, and add an estimated GBP 1 billion to healthcare costs. More than 5,000 people
die every year as a result of these infections. In the US, 1.7 million HAIs occur annually, resulting in more
than 99,000 deaths. On average, HAIs add 19 days to a patient's hospital stay, and increase medical expenses by
more than US$45,000. The US Centers for Disease Control and Prevention estimate that HAIs add $35-$45 billion
in costs to the healthcare system every year.
About Urinary Tract Infections
Urinary tract infections, or UTIs, are the most common type of healthcare-associated infection, accounting for
more than 30% of all reported cases. Urinary catheters, which are inserted in more than five million patients
each year in the US, are associated with 75% of these infections. These patients are placed at higher risk of
developing an infection in their urinary tract. Long term urinary catheterization is used on patients who are
immobile. As a result of catheterization, UTIs affect 10%-12% of all urinary catheter users, adding billions of
dollars in additional costs to the healthcare system, and killing over 13,000 patients in the US every year.
About Ondine Biomedical Inc.
Ondine is developing non-antibiotic therapies for the treatment of a broad spectrum of bacterial, fungal and
viral infections. The Company is focused on developing leading edge products utilizing its patented light-
activated technology, primarily for the healthcare-associated infection (HAI) market. Photodisinfection
provides broad-spectrum antimicrobial efficacy without encouraging the formation and spread of antibiotic
resistance. The Company is based in Vancouver, British Columbia, Canada, with a research and development
laboratory in Bothell, Washington, USA. For additional information, please visit the Company's website at:
www.ondinebio.com.
Forward-Looking Statements:
Certain statements contained in this release containing words like "believe", "intend", "may", "expect" and
other similar expressions, are forward-looking statements that involve a number of risks and uncertainties.
Factors that could cause actual results to differ materially from those projected in the Company's forward-
looking statements include the following: market acceptance of our technologies and products; our ability to
obtain financing; our financial and technical resources relative to those of our competitors; our ability to
keep up with rapid technological change; government regulation of our technologies; our ability to enforce our
intellectual property rights and protect our proprietary technologies; the ability to obtain and develop
partnership opportunities; the timing of commercial product launches; the ability to achieve key technical
milestones in key products and other risk factors identified from time to time in the Company's public filings.
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FOR FURTHER INFORMATION PLEASE CONTACT:
Ondine Biomedical Inc.
Carolyn Cross
Chairman and CEO
ccross@ondinebio.com
www.ondinebio.com
OR
Canaccord Genuity Limited
Ryan Gaffney/Bhavesh Patel
Nominated Adviser
+4420 7050 6500
Ondine Biomedical Inc.
Ondine Biomed (LSE:OBP)
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