ISON Isonics Corporation New (CE)

If the notification relates to a portion of the filing checked above, identify the Item(s) to which the notification relates:

PART I — REGISTRANT INFORMATION

PART II — RULES 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense and the registrant seeks relief pursuant to Rule 12b-25(b), the following should be completed. (Check box if appropriate)

PART III — NARRATIVE

State below in reasonable detail why Forms 10 - K, 20 - F, 11 - K, 10 - Q, 10 - D, N - SAR, N - CSR, or the transition report or portion thereof, could not be filed within the prescribed time period.

(Attach extra Sheets if Needed)

Because Isonics Corporation (the “Company”) is short-staffed, it could not compile its financial information and corresponding disclosure contained in its quarterly report in a timely manner in order to allow management to complete a review of the financial statements and corresponding disclosure by the filing deadline.

PART IV — OTHER INFORMATION

ISONICS CORPORATION

(Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned hereunto duly authorized.

INSTRUCTION: The form may be signed by an executive officer of the registrant or by any other duly authorized representative. The name and title of the person signing the form shall be typed or printed beneath the signature. If the statement is signed on behalf of the registrant by an authorized representative (other than an executive officer), evidence of the representative’s authority to sign on behalf of the registrant shall be filed with the form.

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ATTACHMENT 1 TO

FORM 12b-25

NOTIFICATION OF LATE FILING

For the three and six month periods ended October 31, 2008, the Company’s revenues decreased by approximately 34% and 26% respectively when compared to the comparable periods in our previous fiscal year.   These decreases were caused by declines in revenues for both of our business segments. The decrease in revenue for our security services segment for the three and six months ended October 31, 2008, is primarily due to the effect of the loss of several security services contracts during the year ended April 30, 2008 and the six months ended October 31, 2008.    Effective August 1, 2008, a customer that accounted for $1,459,000 of revenue for the six months ended October 31, 2007 ceased using our services.   Our silicon products and services business segment experienced decreased revenues in part as a result of the weakened business results and inventory buildups experienced by many of our customers.   Our operating loss for the three months ended October 31, 2008 was approximately half of that realized in the second quarter of fiscal 2008, however, our operating loss for the six months ended October 31, 2008 was approximately 8% greater during the six month period ended October 31, 2008 as compared to the comparable period in the previous year.  In large part the decrease in loss from operations during the second quarter was the result of the cost cutting initiatives we implemented.  Our operating loss for the six month period ended October 31, 2008 was negatively impacted by the inclusion of a $2,346,000 non-cash write-down of goodwill during the period which resulted from the loss of a significant customer for our security services business unit.

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