Noticias Fate Therapeutics Inc - FATE | Acciones NASDAQ

Mejore su cartera: debates en tiempo real e ideas comerciales prácticas.

Premium

Fate Therapeutics Presents New Phase 1 Clinical Data of FT819 Off-the-shelf, CAR T-cell Product Candidate for Systemic Lupus Erythematosus

All Three Patients Treated in First Dose Cohort Administered Fludarabine-free Conditioning and Show Rapid...

Fate Therapeutics Reports New Employee Inducement Award Under Nasdaq Listing Rule 5635(c)(4)

SAN DIEGO, Dec. 03, 2024 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage...

Form 8-K - Current report

Fate Therapeutics Announces Leadership Transition

Bob Valamehr, Ph.D. MBA, To Become President and CEO January 1, 2025 Scott Wolchko To Retire as President and...

Fate Therapeutics to Present at Upcoming December Investor Conferences

SAN DIEGO, Nov. 26, 2024 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage...

Fate Therapeutics Presents 6-Month Follow-up Data on First Patient Treated in Phase 1 Autoimmunity Study with Fludarabine-free Conditioning and FT819 Off-the-shelf, 1XX CAR T-cell Product Candidate at ACR Convergence

27-year-old African American-Asian Woman with Active Lupus Nephritis Achieved DORIS Clinical Remission; Patient...

Fate Therapeutics Highlights FT522 Off-the-shelf, ADR-armed CAR NK Cell Product Candidate at 2024 ACR Convergence

Phase 1 Basket Study for B Cell-mediated Autoimmune Diseases to Assess FT522 as Add-on to Standard-of-care...

Form SC 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Form 10-Q - Quarterly report [Sections 13 or 15(d)]

Form 8-K - Current report

Fate Therapeutics Reports Third Quarter 2024 Financial Results and Business Updates

Initial Clinical Data from Phase 1 Autoimmunity Study of FT819 1XX CAR T-cell Product Candidate to be Presented...

Fate Therapeutics Highlights Cancer-selective, HER2-Targeting Profile of FT825 / ONO-8250 CAR T-cell Product Candidate for Treatment of Advanced Solid Tumors at 2024 SITC Annual Meeting

Novel H2CasMab-2 Antigen Binding Domain Shown to Preferentially Target HER2 Expressed on Tumor Cells in...

Form SC 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Fate Therapeutics Presents Pan-tumor Targeting Preclinical Data for FT836 MICA/B-targeted CAR T-cell Product Candidate at 2024 SITC Annual Meeting

Multiplexed-engineered, iPSC-derived CAR T Cell Targets Proteins Expressed on Cancer Cells in Response to...

Fate Therapeutics Reports New Employee Inducement Award Under Nasdaq Listing Rule 5635(c)(4)

SAN DIEGO, Nov. 04, 2024 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage...

NY1972 15 horas hace

Ft825 - 4 more sites added

👍️0

NY1972 3 días hace

FT819 can act as a ligand sink and change DC/CD8, NLR ratios in 2nd lymphoid and inflammed tissues. Creating a new Bronx so to speak.

CXCR4 is critical for the organization of secondary lymphoid tissues, such as lymph nodes and spleen, where immune responses are initiated.
Dysregulation of CXCR4 signaling may contribute to abnormal germinal center reactions and the development of autoreactive immune cells.

👍️0

jondoeuk 3 días hace

Maybe they thought that better penetration into the bone marrow could allow for greater effectiveness in targeting certain types, such as B-ALL. CXCR4 is critical for bone marrow homing of T-cells https://onlinelibrary.wiley.com/doi/10.1002/eji.201747438 https://journals.aai.org/jimmunol/article/193/3/1013/108777/Cutting-Edge-CXCR4-Is-Critical-for-CD8-Memory-T

I know they have a patent for hematopoietic stem or progenitor cells being contacted with an agent that increases CXCR4 gene expression in the cells.

However, the iTs (that are either contacted with that agent or not) express high levels of Fas https://www.jci.org/articles/view/121491 https://www.nature.com/articles/s41467-017-00784-1 https://www.nature.com/articles/nm.3541

To overcome it, this was created https://aacrjournals.org/cancerres/article/84/6_Supplement/3995/740628/Abstract-3995-A-novel-chimeric-Fas-signal-redirect

👍️0

NY1972 4 días hace

Why FT819 has high CXCR4 expression?

👍️0

NY1972 6 días hace

Rearranging the deck.
Follicular structures were disrupted and FDCs were depleted in the lymph nodes after CD19-CAR T-cell therapy, but not after RTX
Let see if FT825 can do the same with LD and Cetuximab.
https://ard.bmj.com/content/annrheumdis/early/2024/09/11/ard-2024-226142.full.pdf

👍️0

NY1972 7 días hace

The key is in CART and neutrophil interactions within the draining lymph nodes. Neutrophils build TME and suppress CD8+ /NK via Treg. For the primary tumor, CART will need mAb to deal with antigen escape.

https://aacrjournals.org/cancerrescommun/article/4/2/588/734969/Characterizing-Neutrophil-Subtypes-in-Cancer-Using

👍️0

jondoeuk 1 semana hace

I want to say one of two, but can't remember off the top of my head.

👍️0

jondoeuk 1 semana hace

Metastatic cancer cells can develop multiple (suppressive) mechanisms that enable the evasion of NKs, such as this https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01206-3

In one patent the same group goes on to show that EP2/EP4 KO enables the NKs to secrete chemokines, such as XCL1 that recruit key immune cell populations required for T-cell mediated tumour immunity https://www.cell.com/cell/fulltext/S0092-8674(18)30039-4

In another paper, a different group identifies IGSF8 as a new immune checkpoint that suppresses NKs (and dendritic cells) in antigen presentation deficient cancer cells https://www.cell.com/cell/abstract/S0092-8674(24)00355-6

So I think the right combination of edits will be needed to overcome trafficking, infiltration, potency, expansion, persistence, while also preventing exhaustion/dysfunction, suppression, tackle antigen heterogeneity and evasion.

👍️0

NY1972 2 semanas hace

Which other bios have CART with CXCR2? That feature is critical after lymphodepletion causing BM suppression for 2 weeks.

👍️0

NY1972 2 semanas hace

Sounds like what one would find in SLE, cancer pts with a reset immune system.

?d T-cell proliferation was dependent upon CD137L expression on aAPC and addition of exogenous IL2 and IL21. Propagated ?d T cells were polyclonal

👍️0

jondoeuk 2 semanas hace

For many, many years the focus was on the Vd2 subset, but recent evidence in multiple tumours showed associations of other subsets (Vd1 and/or Vd3) with increased patient survival and/or clinical benefit https://www.nature.com/articles/s43018-022-00376-z https://www.science.org/doi/10.1126/scitranslmed.aax9364

There is also preclinical data which show that the Vd1 subset has superior cytotoxicity over Vd2 https://aacrjournals.org/clincancerres/article/20/22/5708/117332/Activating-and-Propagating-Polyclonal-Gamma-Delta

👍️0

NY1972 2 semanas hace

NK is fine for SLE since the depletion of the memory B cells is the goal. For solid, creating polyclonal T cells with memory phenotype is the key for OR duration.
From ChatGPT:
Studies with 1XX CAR T cells highlight their enhanced capacity for cytokine production and survival, suggesting a stronger potential for interaction with and modulation of DCs compared to conventional CAR T cells. Dendritic cells in the TME can process these antigens and cross-prime endogenous T cells against TAAs, creating a polyclonal immune response that complements the CAR T-cell activity.

👍️0

jondoeuk 2 semanas hace

They should get a B7-H3 CAR into the clinic https://www.oncologypipeline.com/apexonco/fourth-challenger-dualitybio-and-biontech

Based on preclinical data targeting the IgC domain is more effective https://www.nature.com/articles/s41467-023-41631-w

👍️0

jondoeuk 2 semanas hace

Unlike NKs, the differentiation of T-cells from iPSCs is (far) more complex. Also, the NKs from iPSCs are more comparable functionality to PB/CB NKs, and can kill independent from the CAR.

It would make sense to test the two https://aacrjournals.org/cancerimmunolres/article/7/3/363/469550/NK-Cells-Expressing-a-Chimeric-Activating-Receptor

But there are still hurdlers (for the NKs) to overcome, including persistence and lack of expansion. The use of an IL15-RF may impair NK functions as well https://insight.jci.org/articles/view/96219 https://www.pnas.org/doi/10.1073/pnas.1012128107

👍️0

NY1972 2 semanas hace

1xx, autologous T cells and lactate
https://pmc.ncbi.nlm.nih.gov/articles/PMC11588660/

👍️0

NY1972 2 semanas hace

SP from 100 to 1 while revamped pipeline from 1 to 100

👍️0

NY1972 2 semanas hace

CEO was pretty bullish on 825 + cetuximab. I think Ig1 is as effective as TCE as it activates the innate arm.

👍️0

jondoeuk 2 semanas hace

FT825 would require an additional receptor https://ashpublications.org/blood/article/140/Supplement%201/7429/491146/A-CD3-Fusion-Receptor-CD3-FR-Uniquely-Enables

👍️0

NY1972 2 semanas hace

Failure to revive old cells
https://www.merck.com/news/merck-provides-update-on-keyvibe-and-keyform-clinical-development-programs-evaluating-investigational-vibostolimab-and-favezelimab-fixed-dose-combinations-with-pembrolizumab/

👍️0

NY1972 3 semanas hace

FATE revamped it's cell to deal with TME. Yet the SP is 1.8% of what it used to be. 95% investors were in it for ride because J&J was on board. They had little understanding of science.

👍️0

NY1972 3 semanas hace

Why bother with CARNK after they licensed 1xx from MSK. CAR T 1xx lowers the activation and energy req'd to survive in the hypoxic TME. More durable and lower CRS CART therapy will beat ADC in terms of AE and OS long term.

👍️0

jondoeuk 3 semanas hace

Hard to say. After the termination of a 2020 collaboration agreement with Johnson & Johnson's subsidiary Janssen, FATE slashed its pipeline, including FT536, FT516, FT596 and FT538.

👍️0

NY1972 3 semanas hace

The combination of p95HER2.CAR T cells and HER2?x?CD3 bispecific antibodies lead to a complete regression in three HER2-positive, patient-derived mouse xenografts tumor models
https://pmc.ncbi.nlm.nih.gov/articles/PMC11574131/

👍️0

NY1972 3 semanas hace

So they abandoned FT536 after looking at PK in 6 pts.

👍️0

jondoeuk 3 semanas hace

I am looking for some FT536 P1 data to figure out why they decided on 3 day dosing at U of M?

Either based on data from other trials and/or the biology of NKs (they do not typically expand upon encounter with antigen and lack long-term persistence). It looks to be a compressed dosing schedule, which could extend exposure and increase Cmax levels.

That poster only listed 3 pts dosed at 100M cells mono, how about higher dosages?

Monotherapy escalation was continuing at 300 million cells/dose. So I assume (rightly or wrongly) that those two patients had been treated at this dose level. From memory, they were going to test at least a third dose level as well (500 million cells/dose). Also, had an option to add IL-2 once the MTD had been reached.

👍️0

NY1972 3 semanas hace

I am looking for some FT536 P1 data to figure out why they decided on 3 day dosing at U of M? That poster only listed 3 pts dosed at 100M cells mono, how about higher dosages?

👍️0

jondoeuk 3 semanas hace

They presented initial data at SITC '22 (another two were enrolled before it was terminated) https://fatetherapeutics.com/wp-content/uploads/2022/11/SITC2022_FT536_FinalDraft-VFINAL.pdf

Another trial (not sponsored by FATE) is ongoing https://clinicaltrials.gov/study/NCT06342986

👍️0

jondoeuk 3 semanas hace

A number of biotechs were hit (hard) this week.

👍️0

NY1972 3 semanas hace

Have you seen the clinical data from FT536 P1?

👍️0

NY1972 3 semanas hace

What is the hidden message that caused the selloff?

👍️0

NY1972 3 semanas hace

2025 is the year of 1xx. HER2 ADC sales is $5B. 825 + cetuximab beats ADCs

👍️0

jondoeuk 3 semanas hace

The news https://www.globenewswire.com/news-release/2024/12/09/2994080/24675/en/Fate-Therapeutics-Presents-New-Phase-1-Clinical-Data-of-FT819-Off-the-shelf-CAR-T-cell-Product-Candidate-for-Systemic-Lupus-Erythematosus.html

👍️0

jondoeuk 3 semanas hace

Hopefully, another (small) pop tomorrow based on the latest news.

👍️0

glenn1919 4 semanas hace

FATE...........................https://stockcharts.com/h-sc/ui?s=FATE&p=W&b=5&g=0&id=p86431144783

👍️0

NY1972 4 semanas hace

"Different subsets are important for activity"
I think that just reflect the ever changing immune makeup as body reacts to new and existing stimulus. Just like macrophages that are not 100% M1 or M2.

👍️0

jondoeuk 4 semanas hace

For oncology, it will be put on the back burner.

👍️0

jondoeuk 4 semanas hace

Turns out a few companies screened a CAR panel, including CD3 family, ITAM silent, etc. So it could be possible. As for gd-T cells, results from one group indicated that igd-T cells have differences when compared to PB-derived gd-T cells https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(23)00057-7

Different subsets are important for activity https://www.nature.com/articles/s41586-022-05593-1

👍️0

NY1972 1 mes hace

Improved Memory Phenotypes: The reduced stress allows a greater proportion of 1XX CAR T cells to retain central memory and effector memory phenotypes, which are crucial for long-term persistence and functionality.
Lower Cytokine Production: By producing cytokines at more moderate levels, 1XX CAR T cells avoid the excessive metabolic demands and inflammatory feedback loops that can lead to early cell death or dysfunction.
the higher stress in CAR T cells can make them more susceptible to NK cell-mediated clearance.

👍️0

NY1972 1 mes hace

New CEO before ASH. PhD likes CAR T with 1xx.

👍️0

NY1972 1 mes hace

Other ipsc bios can't use 1xx
"We have exclusively licensed from MSKCC foundational intellectual property covering iPSC-derived cellular immunotherapy, including T-cells and
NK cells derived from iPSCs engineered with CARs, for human therapeutic use. We have also licensed from MSKCC intellectual property covering
compositions of novel CAR constructs, including the use of a novel 1XX co-stimulatory domain, and of genetically engineered CAR T-cells, including
methods of making these cells using CRISPR for certain targeted gene modifications."

👍️0

jondoeuk 1 mes hace

Dr. Huntington is the CSO. From this https://acir.org/weekly-digests/2024/november/sitc-39th-annual-meeting-2024#2

''A 2008 NCI survey identified IL-15 as one of the top cytokines for potential immunotherapy, and multiple subsequent studies have demonstrated a critical role for IL-15 in multiple immune cell types. Further, direct and correlative data have linked IL-15 to good outcomes in animals and humans. Nonetheless, IL-15R agonists have failed in the clinic due to severe toxicity.

Spurred on by this challenge, Nicholas Huntington focused on how to target the signaling-induced inhibitory pathway, reasoning that although IL-15R is widespread throughout the body, IL-15 levels are very low in healthy tissue (but high in tumors) and that by preventing receptor degradation, cells would be hyperresponsive to the IL-15 produced in the tumor and not activated systemically. A CRISPR knockout screen in human NK cells under conditions of low IL-15 identified a number of genes (UBE2F, ARIH2, CISH, CUL5, RNF7, DCUN1D3, UBE2L3, ELOC), whose elimination allowed better NK cell growth.

All these genes were involved in protein homeostasis affecting neddylation and subsequent ubiquitination, leading to degradation. Functionally validating these results, individual knockouts of these genes in NK cells and the NK-92 cell line enhanced proliferation, cytokine production, and metabolic features of the NK cells, and the expected upregulation of IL-15R surface detection. Importantly, an inhibitor of pan-neddylation phenocopied the effects of UBE2F-gene knockouts, supporting that the pathway could be targeted for therapy.

Serial cytotoxicity studies with gene knockouts in NK cells or CAR NK cells demonstrated robust serial killing, indicating the cells were metabolically very fit and resistant to exhaustion, which translated to enhanced control of MHC-I-expressing or -deficient tumors in syngeneic mouse models. The unexpected observation of activity against MHC-I-expressing tumors was a direct effect of CD8+ T cells, but enhanced by hyperactive NK-mediated improvements to the T cell response. Most of the identified gene targets were part of a degradative pathway; some could be deleted with minimal effects, and so were non-essential. Importantly, some of these targets were enzymes, setting up the opportunity to identify small molecular inhibitors specific to this class of drug targets.''

👍️0

jondoeuk 1 mes hace

A number of companies have licensed it. Based on new data is seems that there is no one-size-fits-all, so pooled screening of different CARs to try and find the best for specific types will be needed https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(23)00495-1

👍️0

NY1972 1 mes hace

Can they license CAR 1xx from MSK?

👍️0

NY1972 1 mes hace

3 pts remain on study. No relapse. Sounds like a telegraph?

👍️0

glenn1919 1 mes hace

FATE.........................https://stockcharts.com/h-sc/ui?s=FATE&p=W&b=5&g=0&id=p86431144783

👍️0

jondoeuk 1 mes hace

A post on LinkedIn (by Alex Shih-Min Huang who is VP, Head of Cell Therapy at BGNE): ''Though our very first experiment was initiated only 2.5 years ago amidst ongoing laboratory construction and pandemic, fast forward to this day, we have already 1) generated a proprietary, well-characterized GMP grade iPSC clone collection designated for our future gd T and ab T cellular products, 2) established our unique efficient, enrichment-free, feeder-free methodologies that deliver impressively high purity and high expansion fold for our iPSC derived gd T and iPSC derived CD8 ab T platforms, and 3) engineered proprietary genetic elements that further enhance the longevity and potential efficacy of our effector cell populations. Our platforms are designed to allow plug-and-play for a variety of CAR-T and TCR-T cell therapies with potential to address unmet needs in diverse indications.''

👍️0

jondoeuk 1 mes hace

One for FT819 as well https://www.globenewswire.com/news-release/2024/11/18/2982757/24675/en/Fate-Therapeutics-Presents-6-Month-Follow-up-Data-on-First-Patient-Treated-in-Phase-1-Autoimmunity-Study-with-Fludarabine-free-Conditioning-and-FT819-Off-the-shelf-1XX-CAR-T-cell-P.html

👍️0

jondoeuk 1 mes hace

The PR https://www.globenewswire.com/news-release/2024/11/18/2982736/24675/en/Fate-Therapeutics-Highlights-FT522-Off-the-shelf-ADR-armed-CAR-NK-Cell-Product-Candidate-at-2024-ACR-Convergence.html

👍️0

jondoeuk 1 mes hace

They need to pick up the pace of enrolment. If they don't see activity at DL2, I think it could be in trouble.

👍️0

jondoeuk 1 mes hace

Big volume into the close, over 12 million. Someone knows something.

👍️0

Datos

Noticias

Herramientas

Mercados

Descubrir

Hot Features

Follow Feed

Flujo de Opciones

Monitor

Fate Therapeutics Inc (FATE)

Mejore su cartera: debates en tiempo real e ideas comerciales prácticas.

FATE Noticias

Fate Therapeutics Presents New Phase 1 Clinical Data of FT819 Off-the-shelf, CAR T-cell Product Candidate for Systemic Lupus Erythematosus

Fate Therapeutics Reports New Employee Inducement Award Under Nasdaq Listing Rule 5635(c)(4)

Form 8-K - Current report

Fate Therapeutics Announces Leadership Transition

Fate Therapeutics to Present at Upcoming December Investor Conferences

Fate Therapeutics Presents 6-Month Follow-up Data on First Patient Treated in Phase 1 Autoimmunity Study with Fludarabine-free Conditioning and FT819 Off-the-shelf, 1XX CAR T-cell Product Candidate at ACR Convergence

Fate Therapeutics Highlights FT522 Off-the-shelf, ADR-armed CAR NK Cell Product Candidate at 2024 ACR Convergence

Form SC 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Form 10-Q - Quarterly report [Sections 13 or 15(d)]

Form 8-K - Current report

Fate Therapeutics Reports Third Quarter 2024 Financial Results and Business Updates

Fate Therapeutics Highlights Cancer-selective, HER2-Targeting Profile of FT825 / ONO-8250 CAR T-cell Product Candidate for Treatment of Advanced Solid Tumors at 2024 SITC Annual Meeting

Form SC 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Fate Therapeutics Presents Pan-tumor Targeting Preclinical Data for FT836 MICA/B-targeted CAR T-cell Product Candidate at 2024 SITC Annual Meeting

Fate Therapeutics Reports New Employee Inducement Award Under Nasdaq Listing Rule 5635(c)(4)

FATE Discussion

Su Consulta Reciente

Empresa

Negocios

Popular

Obtener la aplicación

Tendencias Ahora

Listas Principales

Datos

Noticias

Herramientas

Mercados

Descubrir

Hot Features

Follow Feed

Flujo de Opciones

Monitor

Fate Therapeutics Inc (FATE) Noticias

Fate Therapeutics Inc (FATE)

Mejore su cartera: debates en tiempo real e ideas comerciales prácticas.

FATE Noticias

Fate Therapeutics Presents New Phase 1 Clinical Data of FT819 Off-the-shelf, CAR T-cell Product Candidate for Systemic Lupus Erythematosus

Fate Therapeutics Reports New Employee Inducement Award Under Nasdaq Listing Rule 5635(c)(4)

Form 8-K - Current report

Fate Therapeutics Announces Leadership Transition

Fate Therapeutics to Present at Upcoming December Investor Conferences

Fate Therapeutics Presents 6-Month Follow-up Data on First Patient Treated in Phase 1 Autoimmunity Study with Fludarabine-free Conditioning and FT819 Off-the-shelf, 1XX CAR T-cell Product Candidate at ACR Convergence

Fate Therapeutics Highlights FT522 Off-the-shelf, ADR-armed CAR NK Cell Product Candidate at 2024 ACR Convergence

Form SC 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Form 10-Q - Quarterly report [Sections 13 or 15(d)]

Form 8-K - Current report

Fate Therapeutics Reports Third Quarter 2024 Financial Results and Business Updates

Fate Therapeutics Highlights Cancer-selective, HER2-Targeting Profile of FT825 / ONO-8250 CAR T-cell Product Candidate for Treatment of Advanced Solid Tumors at 2024 SITC Annual Meeting

Form SC 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Fate Therapeutics Presents Pan-tumor Targeting Preclinical Data for FT836 MICA/B-targeted CAR T-cell Product Candidate at 2024 SITC Annual Meeting

Fate Therapeutics Reports New Employee Inducement Award Under Nasdaq Listing Rule 5635(c)(4)

FATE Discussion

Su Consulta Reciente

Empresa

Negocios

Popular

Obtener la aplicación