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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM 8-K

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): December 19, 2024

 

 

IO Biotech, Inc.

(Exact name of Registrant as Specified in Its Charter)

 

 

 

Delaware   001-41008   87-0909276

(State or Other Jurisdiction

of Incorporation)

 

(Commission

File Number)

 

(IRS Employer

Identification No.)

Ole Maaløes Vej 3

DK-2200 Copenhagen N

Denmark

(Address of Principal Executive Offices) (Zip Code)

Registrant’s Telephone Number, Including Area Code: +45 7070 2980

N/A

(Former Name or Former Address, if Changed Since Last Report)

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class

 

Trading
Symbol(s)

 

Name of each exchange

on which registered

Common Stock, par value $0.001 per share   IOBT   The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. 

 

 

 


Item 1.01.

Entry into a Material Definitive Agreement.

Finance Contract and Guarantee Agreement

On December 19, 2024, IO Biotech ApS, a private limited liability company incorporated in Denmark and wholly-owned subsidiary (the “Borrower”) of IO Biotech, Inc., a Delaware corporation (the “Company”) entered into a Finance Contract (the “Finance Contract”) with the European Investment Bank (“EIB”), establishing three tranches of potential financing in an aggregate principal amount of up to €37.5 million, subject to certain conditions precedent (the “EIB Loan Facility”).

Pursuant to the Finance Contract, the Company (through the Borrower) will have €10.0 million available to draw in an initial tranche of the term loan facility (“Tranche A”), subject to satisfaction of certain customary conditions and the issuance of warrants pursuant to a Warrant Issuance Agreement (described below). The Tranche A loan is expected to be available in January 2025.

The Finance Contract provides for two potential additional term loan tranches in principal amounts of €12.5 million (“Tranche B”) and €15.0 million (“Tranche C” and, together with Tranche A and Tranche B, each a “Tranche”), respectively, each of which is subject to specified conditions, including, but not limited, the issuance of warrants and achievement of certain clinical trial and other milestones. The milestone for the Tranche B loan has already been achieved, and accordingly the Tranche B loan is expected to be available in January 2025. The Borrower has 36 months to satisfy the conditions for Tranche C, which include raising an additional $50 million in cash and submission of an application for marketing authorization for IO102-IO103 in the U.S. or the EU.

Each of the Tranche A, Tranche B, and Tranche C loans will bear interest at a fixed rate of 8% that accrues annually and will become payable at their respective maturity dates, which will be six years after disbursement of such loan. The proceeds of each loan are expected to be used to continue to fund the Company’s ongoing clinical trials.

Any unpaid balance owed under the Finance Contract may be accelerated upon an Investment Cost Reduction Event, a Change-of-Control Event, a Change-of-Law Event, an Illegality Event or a Voluntary Non-EIB Prepayment Event (each as defined in the Finance Contract).

If the Borrower elects to voluntarily prepay any Tranche, the Borrower will be required to additionally pay to EIB a prepayment fee ranging from 5% of the Tranche, if repaid within twelve months of disbursement of such Tranche, to 1% of the Tranche, if repaid after the third anniversary of disbursement of such Tranche. No such prepayment fee is payable after the fourth anniversary of disbursement of the applicable Tranche.

Also on December 19, 2024, the Company entered into a guarantee agreement (the “Guarantee Agreement”) with EIB, pursuant to which it granted a first-demand payment guarantee in favor of EIB regarding the obligations of the Borrower under the Finance Contract.

The Finance Contract and the Guarantee Agreement contain customary representations, warranties and covenants that were made solely for the benefit of the parties to the Finance Contract and the Guarantee Agreement. Such representations, warranties and covenants (i) are intended as a way of allocating risk between the parties to the Finance Contract and Guarantee Agreement and not as statements of fact, and (ii) may apply standards of materiality in a way that is different from what may be viewed as material by stockholders of, or other investors in, the Company. Accordingly, the Finance Contract and Guarantee Agreement are included with this filing only to provide investors with information regarding the terms of the transaction and not to provide investors with any other factual information regarding the Company. Investors should not rely on the representations, warranties and covenants or any descriptions thereof as characterizations of the actual state of facts or condition of the Company or any of its subsidiaries or affiliates. Moreover, information concerning the subject matter of the representations and warranties may change after the date of the Finance Contract and Guarantee Agreement, which subsequent information may or may not be fully reflected in public disclosures.

Side Letter

Concurrently with the execution of the Finance Contract, the Borrower entered into a non-binding side letter, pursuant to which EIB may, in its discretion and subject to approvals by its investment committee, make available to the Borrower an additional €20.0 million in funding related to the Company’s ongoing clinical trials.


Warrants

In connection with the Finance Contract, the Company also entered into a warrant issuance agreement (the “Warrant Issuance Agreement”) on December 19, 2024, pursuant to which the Company agreed to sell and issue to EIB certain warrants to purchase shares of the Company’s common stock, par value $0.001 per share (the “Common Stock”) in connection with the disbursement of each of the Tranche A loan (such warrants, the “Tranche A Warrants”), Tranche B loan (such warrants, the “Tranche B Warrants”) and Tranche C loan (such warrants, the “Tranche C Warrants” and, together with the Tranche A Warrants and the Tranche B Warrants, the “Warrants”). The number of shares for which the Warrants will be exercisable will be determined at the time of issuance of each Warrant in accordance with the formulas set forth in the Warrant Issuance Agreement, which formulas generally provide that the number of shares will decrease as the price of the Common Stock increases.

Under the terms of each Warrant, each share of Common Stock issuable upon exercise thereof shall have an exercise price equal to the greater of (x) the Company’s 5-Day VWAP on the date of execution of the applicable Warrant and (y) the applicable “Minimum Price” as defined in Nasdaq Rule 5635(d), in each case subject to adjustment. The Tranche A Warrant shall become initially exercisable on the date of disbursement of the Tranche A loan; the Tranche B Warrant shall become initially exercisable on the date of disbursement of the Tranche B loan; and the Tranche C Warrant shall become initially exercisable on the date of disbursement of the Tranche C loan. Each Warrant shall be exercisable until the earlier of one day prior to the closing of an Acquisition (as such term is defined in the applicable Warrant) and twenty years following the date of issuance.

Under the terms of each Warrant, the Company has a call option to repurchase the Warrants upon a Change of Control Event, a Qualifying Tender Offer, or a Transformational Transaction (each, as defined in the Warrant).

In connection with an exercise of the Company’s call option, the purchase price for the shares issuable upon exercise of the portion of the Warrant subject to the call option would be equal to the greater of (x) 30% of the amount disbursed under the Finance Contract as of the date of the call option multiplied by a fraction, the numerator of which is (i) the number of Warrant Shares (as defined in the Warrant Agreement) purchasable under the Warrant Agreement and (ii) the denominator which is the number of shares of Common Stock purchasable with respect to all Warrants under the Warrant Issuance Agreement, whether or not remaining outstanding, and (y) the aggregate value of the Warrant Shares purchasable upon exercise of the call option in the event of any of a Qualifying Tender Offer, Transformational Transaction or other transaction, in each case as calculated in accordance with the terms of the Warrant Agreement.

Under the terms of the Warrant Issuance Agreement, EIB has a put option to sell the Warrants to the Company on or following the maturity date of the applicable Tranche or upon the occurrence of an Event Date (as defined in the Warrant Issuance Agreement), subject to certain limitations in the event that the Company publishes a Material Press Release (as defined in the Warrant Issuance Agreement).

In connection with an exercise of EIB’s put option, the purchase price for the shares purchasable in connection with the put option would be equal to (x) in the case of a Qualifying Tender Offer (as defined in the Warrant Issuance Agreement), the aggregate price per share of Common Stock being offered minus the aggregate Strike Price (as defined in the Warrant Issuance Agreement) payable to the Company with respect to the Warrants for which the put option is being exercised and (y) in all other cases, an amount equal to the aggregate Fair Market Value (as defined in the Warrant Issuance Agreement) of the Warrant Shares purchasable upon exercise of the put option minus the aggregate Strike Price payable to the Company with respect to the Warrants for which the put option is being exercised.

Registration Rights Agreement

The Company also entered into a registration rights agreement (the “Registration Rights Agreement”) with EIB related to the issuance of the Warrants. Under the terms of the Registration Rights Agreement, the Company has agreed to prepare and file, by the later of (i) 30 days after the date of issuance of any of the Warrants and (ii) May 15, 2025 (the “Filing Deadline”), one or more registration statements with the Securities and Exchange Commission (the “SEC”) to register for resale the Common Stock issued under the Warrant Issuance Agreement and the shares of Common Stock issuable upon conversion of the Warrants issued pursuant to the Warrant Issuance Agreement, and to cause the applicable registration statements to become effective within a specified period after the Filing Deadline.

The foregoing is only a summary of the terms of the Finance Contract, the Guarantee Agreement, the Side Letter, the Warrant Issuance Agreement, the Warrants issued thereunder, and the Registration Rights Agreement, does not purport to be complete and is qualified in its entirety by reference to the full text of (i) the Finance Contract, a copy


of which is attached to this report as Exhibit 10.1, (ii) the Guarantee Agreement, a copy of which is attached to this report as Exhibit 10.2, (iii) the Side Letter, a copy of which is attached hereto as Exhibit 10.3, (iv) the Warrant Issuance Agreement, a copy of which is attached to this report as Exhibit 10.4, (v) the Registration Rights Agreement, a copy of which is attached to this report as Exhibit 10.5 and (v) the form of Warrant, a copy of which is attached to this report as Exhibit 4.1.

 

Item 2.03

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant.

The disclosure regarding the terms of the Finance Contract as set forth in Item 1.01 of this report is incorporated by reference under this Item 2.03

 

Item 3.02.

Unregistered Sales of Equity Securities.

The disclosure regarding the securities to be sold and issued under the Warrant Issuance Agreement as set forth under Item 1.01 of this report is incorporated by reference under this Item 3.02.

The securities described above under Item 1.01 have not been registered under the Securities Act of 1933, as amended (the “Securities Act”). The Company relied on the exemption from the registration requirements of the Securities Act by virtue of Section 4(a)(2) thereof on the basis that the transaction did not involve a public offering.

 

Item 7.01.

Regulation FD Disclosure.

On December 19, 2024, the Company issued a press release announcing the EIB Loan Facility and expectations regarding extension of its cash runway into the second quarter of 2026. A copy of this press release is attached hereto as Exhibit 99.1.

The information contained in this Item 7.01 and in Exhibit 99.1 hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any other filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

 

Item 9.01

Financial Statements and Exhibits.

(d) Exhibits

 

 4.1    Form of Warrant.
10.1    Finance Contract, dated December 19, 2024, by and between the Borrower and EIB.
10.2    Guarantee Agreement, dated December 19, 2024, by and between the Company and EIB.
10.3    Side Letter, dated December 19, 2024, by and between the Borrower and EIB.
10.4    Warrant Issuance Agreement, dated December 19, 2024, by and between the Company and EIB.
10.5    Registration Rights Agreement, dated December 19, 2024, by and between the Company and EIB.
99.1    Press Release dated December 20, 2024.
104    Cover Page Interactive Data File (embedded within the Inline XBRL document)


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 

    IO Biotech, Inc.
Date: December 20, 2024     By:  

/s/ Mai-Britt Zocca, Ph.D.

      Mai-Britt Zocca, Ph.D.
      Chief Executive Officer

Exhibit 4.1

NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS. THIS SECURITY AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS SECURITY MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN SECURED BY SUCH SECURITIES.

COMMON STOCK WARRANT

IO BIOTECH, INC.

 

Number of Warrant Shares: [___]1

Tranche [A/B/C] 2

   Issue Date: [___]

THIS COMMON STOCK WARRANT (this “Warrant”) certifies that, for value received, [___] or its assigns (the “Warrantholder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) and on or prior to 5:00 p.m. Eastern time on the earlier of (i) [___],3 and (ii) one (1) day prior to the closing of an Acquisition (as defined below) (the earliest of the foregoing, the “Termination Date”) but not thereafter, to subscribe for and purchase from IO Biotech, Inc., a Delaware corporation (the “Company”), up to [___]4 Shares of Common Stock (as subject to adjustment hereunder, the “Warrant Shares”). The purchase price of one Share of Common Stock under this Warrant shall be equal to the Strike Price, as defined in Section 2(b). This Warrant is being issued pursuant to that certain Warrant Issuance Agreement, dated as of December 19, 2024, by and between the Company and the European Investment Bank, as amended and/or restated from time to time (the “Warrant Issuance Agreement”).

Section 1. DEFINITIONS AND INTERPRETATION

 

1.1

Definitions. In this Warrant the following words and expressions will have the following meanings, save where the context requires otherwise:

Acquisition” has the meaning ascribed to it in Section 3(d)(i).

Affiliate” means, in respect of any entity, another entity that directly or indirectly is in Control of, or is Controlled by, or is under common Control with that entity.

 

1 

NOTE TO FORM: To be the number of Warrant Shares purchasable with respect to the given tranche of Warrants calculated in accordance with the Warrant Issuance Agreement.

2 

NOTE TO FORM: To be the applicable Tranche of this Warrant.

3 

NOTE TO FORM: Date to be twenty years from the Issue Date.

4 

NOTE TO FORM: To be the number of Warrant Shares purchasable with respect to the given tranche of Warrants calculated in accordance with the Warrant Issuance Agreement.

 

1


Alternate Consideration has the meaning ascribed to it in Section 3(c).

Applicable Law” means all applicable law and regulation which from time to time is binding on the Company or the Warrantholder.

Attribution Parties” has the meaning ascribed to it in Section 2(e).

Beneficial Ownership Limitation” has the meaning ascribed to it in Section 2(e).

Black Scholes Value has the meaning ascribed to it in Section 3(c).

Bloomberg has the meaning ascribed to it in Section 3(c).

Board of Directors” means the board of directors of the Company from time to time.

Borrower” means IO Biotech ApS, a private limited liability company incorporated in Denmark, and a Subsidiary of the Company, having its registered office at C/O COBISOle Maaløes Vej 3, 2200 København N, Denmark.

Business Day” means a day (other than a Saturday or Sunday) on which the Original Warrantholder and commercial banks are open for general business in Copenhagen, Luxembourg and New York, New York.

Call Option” means the right, but not the obligation, of the Company to repurchase this Warrant (in whole, but not in part) from the Warrantholder in consideration of the payment by the Company to the Warrantholder of the Call Option Price in accordance with the terms of Section 5; provided, however, that the Call Option may only be exercised if the Company simultaneously exercises it under each warrant then issued pursuant to the Warrant Issuance Agreement. For the avoidance of doubt, the Call Option may only be exercised once with respect to each warrant issued pursuant to the Warrant Issuance Agreement and not once with regard to all of the warrants.

Call Option Objection Period” means fifteen (15) Business Days from delivery of the draft Company Call Option Notice.

Call Option Price” means the fee payable in cash by the Company to the Warrantholder following the delivery of the Company Call Option Notice, being an amount equal to the greater of (x) the product of (1) 30% (thirty percent) of the amount disbursed pursuant to the Finance Contract as of the date the Company Call Option Notice is delivered pursuant to Section 5 multiplied by (2) a fraction, the numerator of which is the number of Warrant Shares purchasable hereunder as of such date and the denominator of which is the number of Shares of Common Stock purchasable with respect to all warrants issued pursuant to the Warrant Issuance Agreement (whether or not remaining outstanding) and (y) as applicable:

 

  (a)

with respect to a Call Option exercised in connection with a Qualifying Tender Offer, an amount equal to (i) the product of (1) the price per Share of Common Stock being offered by the applicable offeror multiplied by (2) the number of Warrant Shares purchasable hereunder as of such date minus (ii) the aggregate Strike Price payable to the Company to exercise this Warrant in full as of such date;

 

2


  (b)

with respect to a Call Option exercised in connection with a Transformational Transaction, an amount equal to the positive difference of (i) the greater of (A) the aggregate Fair Market Value of the Warrant Shares purchasable hereunder as of the date that is five Trading Days prior to the announcement of such Transformational Transaction and (B) the aggregate Fair Market Value of the Warrant Shares purchasable hereunder as of the date that is five Trading Days following the announcement of such Transformational Transaction minus (ii) the aggregate Strike Price payable to the Company to exercise this Warrant with respect to such Warrant Shares as of such date; or

 

  (c)

with respect to a Call Option not exercised in connection with a Qualifying Tender Offer or a Transformational Transaction, an amount equal to the positive difference of (i) the aggregate Fair Market Value of the Warrant Shares purchasable hereunder as of the date that the Company Call Option Notice is delivered pursuant to Section 5 minus (ii) the aggregate Strike Price payable to the Company to exercise this Warrant with respect to such Warrant Shares as of such date.

Cash Consideration” has the meaning ascribed to it in Section 3(d)(i).

Change of Control Event” means (i) any person or group of persons acting in concert gains Control of the Company or of any entity directly or ultimately Controlling the Company or (ii) the Company, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially all of its assets in one or a series of related transactions.

Charter” means, with respect to the Company, the Amended and Restated Certificate of Incorporation, filed with the Secretary of State of the State of Delaware on June 8, 2023, as amended or restated from time to time.

Common Stock” means the common stock of the Company, par value $0.001 per Share, provided that upon the occurrence of any event whereby all of the outstanding Shares of common stock of the Company are reclassified, exchanged, combined, substituted, or replaced for, into, with or by securities of a different person or securities of the Company of a different class and/or series, then from and after the consummation of such event, the term “Common Stock” shall mean such securities (and for the avoidance of doubt, such principle shall apply to successive reclassifications, exchanges, combinations, substitutions, replacements or other similar events).

Company Call Option Notice” means a call option notice served by the Company on the Warrantholder in substantially the form set out in Exhibit C.

Control” means the power to direct the management and policies of an entity, whether through the ownership of voting capital, by contract or otherwise; for the avoidance of doubt, owning more than 50% of the shares of an entity would be deemed to constitute Control; “Controlling” has the corresponding meaning.

 

3


Convertible Securities” means any securities (directly or indirectly) convertible into or exercisable or exchangeable for Common Stock, but excluding Options.

Current Market Price” has the meaning ascribed to it in Section 2(c).

DWAC” has the meaning ascribed to it in Section 2(d)(i).

Encumbrance” means any encumbrance, debenture, mortgage, blocking order, court decision, court order, leases, subleases, preliminary agreements on the conclusion of subleases, arrest, execution order, order preventing the sale of any assets, charge, pledge, lien, restriction, assignment, hypothecation, security interest, title retention or any other agreement or arrangement the effect of which is the creation of security, or any other interest, equity or other right of any person (including any right to acquire, option, right of first refusal or right of pre-emption), or any agreement or arrangement to create any of the same.

EUR” or “euro” means the lawful currency of the Member States of the European Union which adopt or have adopted it as their currency in accordance with the relevant provisions of the Treaty on European Union and the Treaty on the Functioning of the European Union or their succeeding treaties.

Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

Expert” means a reputable independent expert appointed in accordance with Exhibit D.

Expert’s Certificate” has the meaning set out in Exhibit D.

Fair Market Value means, on the date of the Company Call Option Notice, the value of a Warrant Share as determined in accordance with the valuation principles set out in paragraph 3 of Exhibit D (for the avoidance of doubt, such principles will apply regardless of whether the valuation is being determined by the Warrantholder, the Company, or the Expert as contemplated by any provision of this Warrant).

Finance Contract” means the Finance Contract (governed by Danish law) dated on or about December 19, 2024, by and between the Borrower and the Original Warrantholder, as lender, as such finance contract may be amended from time to time.

Fundamental Transaction has the meaning ascribed to it in Section 3(c).

Instruments” means:

 

  (d)

all issued and outstanding Shares;

 

  (e)

all Shares capable of being issued by the Company pursuant to the exercise in full of all outstanding rights (whether or not contingent and assuming full performance of any equity-linked or performance-linked rights or instruments) to subscribe for or convert into Shares (including under this Warrant); and

 

4


  (f)

all other issued shares, convertible securities, options, warrants, restricted stock units (RSUs), participation rights, conversion privileges or other rights or instruments which are granted to purchase, subscribe for, convert into or otherwise acquire any shares of the Company.

Material Press Release” means a press release that causes the price per share of Common Stock of the Company to increase or decrease by 5% (five per cent.) or more:

 

  (a)

if the press release is issued prior to the market opening on a Trading Day, during the course of such Trading Day; or

 

  (b)

if the press release is issued during market opening hours on a Trading Day or after market close on a Trading Day, during the course of the subsequent Trading Day.

Nasdaq” has the meaning ascribed to it in Section 2(c).

Notice of Exercise” has the meaning ascribed to it in Section 2(a).

Options” means any warrants or other rights or options to subscribe for or purchase Common Stock or Convertible Securities.

Original Warrantholder” means the European Investment Bank, having its seat at 98-100 Boulevard Konrad Adenauer, L-2950 Luxembourg.

Person” means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.

Qualifying Tender Offer” means any, direct or indirect, purchase offer, tender offer or exchange offer (whether by the Company or another person) pursuant to which all holders of Shares of Common Stock are permitted to sell, tender or exchange all of their Shares for other securities, cash or property, which has been accepted by the holders of 50% or more of the outstanding Shares of Common Stock or 50% or more of the voting power of the Common Stock.

SEC” means the United States Securities and Exchange Commission.

Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

Shares” means the issued shares of any class of capital stock of the Company or, as applicable, shares of any class of capital stock of the Company to be issued, at any given point in time.

 

5


Standard Settlement Period” has the meaning ascribed to it in Section 2(d)(i).

Strike Price” has the meaning ascribed to it in Section 2(b).

Subsidiary” means an entity of which a person has direct or indirect control or owns directly or indirectly more than 50% of the voting capital or similar right of ownership and “control” for this purpose means the power to direct the management and the policies of the entity, whether through the ownership of voting capital, by contract or otherwise.

Supporting Calculations” means the basis of calculation, assumptions, and working papers used to determine Fair Market Value.

Successor Entity has the meaning ascribed to it in Section 3(c).

Trading Day” means a day on which the principal Trading Market is open for trading.

Trading Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on the date in question: the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange, OTCQB, OTCQX or Pink Open Market (or any successors to any of the foregoing).

Transfer Agent” means Computershare Trust Company, N.A., the current transfer agent of the Company, with a mailing address of 150 Royall Street, Suite 101, Canton, Massachusetts 02021 and a telephone number of (800) 736-3001, and any successor transfer agent of the Company.

Transformational Transaction” means any transaction or series of related transactions, other than a Change of Control Event or Qualifying Tender Offer, that results in either (i) a merger with a third party in which the Company is a constituent corporation and the enterprise value of such third party implied by such transaction or transactions exceeds EUR 10,000,000 (ten million euros) (or its equivalent in another currency or currencies), or (ii) the acquisition by the Company of one or more businesses of a third party where the consideration exceeds EUR 10,000,000 (ten million euros) (or its equivalent in another currency or currencies), which in either case of (i) or (ii) would require a public company to file financial statements of the acquired business(es) pursuant to Rule 3-05(b)(2)(iii) or Rule 3-05(b)(2)(iv) of Regulation S-X promulgated under the Securities Act, regardless of whether the Company is then subject to Rule 3-05.

USD” or “$” means United States Dollars, the lawful currency of the United States of America.

VWAP” means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed or quoted on a Trading Market other than OTCQB or OTCQX, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on a Trading Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b) if the foregoing

 

6


clause (a) is not applicable and the Common Stock is then listed on OTCQB or OTCQX, the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable, or (c) if the foregoing clauses (a) and (b) are not applicable and if prices for the Common Stock are then reported on the Pink Open Market (or a similar organization or agency succeeding to its functions of reporting prices), the most recent bid price per Share of the Common Stock so reported, or (d) in all other cases, the fair market value of a Share of Common Stock as determined by an independent appraiser selected in good faith by the Warrantholder and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.

Warrant Register” has the meaning ascribed to it in Section 4(c).

Warrant Share Delivery Date” has the meaning ascribed to it in Section 2(d)(i).

 

1.2

Interpretation

Unless a contrary indication appears, a reference in this Warrant:

 

  (a)

to this Warrant or any other agreement or instrument is a reference to this Warrant or other agreement or instrument as amended, novated, supplemented, extended or restated at any time;

 

  (b)

to Section, paragraph or schedule is, unless stated otherwise, a reference to a Section or paragraph of, or schedule to, this Warrant;

 

  (c)

in a Section or schedule to a paragraph is, unless otherwise stated, a reference to a paragraph in that Section or schedule, where that schedule is split into parts, a reference to a paragraph in that part of that schedule;

 

  (d)

to a statute or statutory provision includes a reference to any subordinate legislation and is a reference to:

 

  (i)

that statute, statutory provision or subordinate legislation as modified, consolidated, superseded, re-enacted, re-numbered, or replaced (whether with or without modification) from time to time after the date of this Warrant; and

 

  (ii)

any statute, statutory provision or subordinate legislation which it consolidates, supersedes, re-enacts or replaces (whether with or without modification);

 

  (e)

to a party will be deemed to be a reference to any successor to such party or to any person or persons to whom that party assigns or otherwise transfers any or its rights or obligations under this Warrant in accordance with this Warrant;

 

  (f)

to the Warrantholder in the context of any Warrant or related Warrant Share means the person or persons within the definition of “Warrantholder” who at that time holds or hold that Warrant;

 

7


  (g)

to one gender is a reference to all or any genders, and references to the singular include the plural and vice versa;

 

  (h)

to a legal term for a legal document, court, judicial process, action, remedy, legal status, official or any other legal concept or thing which is specific to a particular jurisdiction shall, in respect of any other jurisdiction, be deemed to be a reference to whatever most closely equates to that legal term in the relevant jurisdiction;

 

  (i)

or” is not exclusive; and

 

  (j)

to “including” or “includes” does not limit the scope of the meaning of the words preceding it but shall be taken as meaning “including without limitation” or “includes without limitation.

 

1.3

The exhibits form part of this Warrant and a reference to “this Warrant” includes its exhibits.

 

1.4

The recitals, index and headings in this Warrant do not affect its interpretation.

Section 2. EXERCISE.

 

  (a)

Exercise of Warrant. Exercise of the purchase rights represented by this Warrant may be made, in whole or in part, at any time or times on or after the Initial Exercise Date and on or before the Termination Date by delivery to the Company of a duly executed PDF copy submitted by e-mail (or e-mail attachment) of the Notice of Exercise substantially in the form set out in Exhibit A hereto (the “Notice of Exercise”). Within the earlier of (i) two (2) Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period following the date of exercise as aforesaid, the Warrantholder shall deliver the aggregate Strike Price for the Warrant Shares specified in the applicable Notice of Exercise by wire transfer unless the cashless exercise procedure specified in Section 2(c) below is specified in the applicable Notice of Exercise. No wet ink-original Notice of Exercise shall be required, nor shall any medallion guarantee (or other type of guarantee or notarization) of any Notice of Exercise be required. Notwithstanding anything herein to the contrary, the Warrantholder shall not be required to physically surrender this Warrant to the Company until the Warrantholder has purchased all of the Warrant Shares available hereunder and this Warrant has been exercised in full, in which case, the Warrantholder shall surrender this Warrant to the Company for cancellation within three (3) Trading Days of the date on which the final Notice of Exercise is delivered to the Company. Partial exercises of this Warrant resulting in purchases of a portion of the total number of Warrant Shares available hereunder shall have the effect of lowering the outstanding number of Warrant Shares purchasable hereunder in an amount equal to the applicable number of Warrant Shares purchased. The Warrantholder and the Company shall maintain records showing the number of Warrant Shares purchased and the date of such purchases. The Company shall deliver any objection to any Notice of Exercise within one (1) Trading Day of receipt of such notice. The Warrantholder and any assignee, by acceptance of this Warrant, acknowledge and agree that, by reason of the provisions of this paragraph, following the purchase of a portion of the Warrant Shares hereunder, the number of Warrant Shares available for purchase hereunder at any given time may be less than the amount stated on the face hereof.

 

8


  (b)

Strike Price. The exercise price per Share of Common Stock under this Warrant shall be [___]5, subject to adjustment as contemplated hereunder (the “Strike Price”).

 

  (c)

Cashless Exercise. If at any time after the Initial Exercise Date, there is no effective registration statement registering, or no current prospectus available for, the issuance or resale of the Warrant Shares to the Warrantholder, then this Warrant may also be exercised, in whole or in part, at such time by means of a “cashless exercise” in which the Warrantholder shall be entitled to receive a number of Shares of Common Stock computed using the following formula:

 

   X =   

Y (B-A)

  B

Where:    X =    the number of Shares of Common Stock to be issued to the Warrantholder.
   Y =    the number of Shares of Common Stock purchasable upon exercise of all of this Warrant or, if only a portion of this Warrant is being exercised, the portion of this Warrant being exercised.
   A =    the Strike Price.
   B =    the Current Market Price of one Share of Common Stock.

Current Market Price” means on any particular date:

 

  (a)

if the Common Stock is traded on The Nasdaq Stock Market (“Nasdaq”), the closing price of the Common Stock of the Company on such market on the day prior to the applicable date of valuation;

 

  (b)

if the Common Stock is traded on any registered national stock exchange but is not traded on Nasdaq, the closing price of the Common Stock of the Company on such exchange on the day prior to the applicable date of valuation;

 

  (c)

if the Common Stock is traded over-the-counter, but not on Nasdaq or another registered national stock exchange, the closing bid price of the Common Stock of the Company on the day prior to the applicable date of valuation; and

 

5 

NOTE TO FORM: To be the initial strike price calculated in accordance with the Warrant issuance Agreement.

 

9


  (d)

if there is no active public market for the Common Stock, the fair market value of a Share of Common Stock, as determined by an independent appraiser selected in good faith by the Warrantholder, the fees and expenses of which shall be paid by the Company.

 

  (d)

Mechanics of Exercise.

 

  (i)

Delivery of Warrant Shares Upon Exercise. The Company shall cause the Warrant Shares purchased hereunder to be transmitted by the Transfer Agent to the Warrantholder by crediting the account of the Warrantholder’s or its designee’s balance account with The Depository Trust Company through its Deposit or Withdrawal at Custodian system (“DWAC”) if the Company is then a participant in such system and either (A) there is an effective registration statement permitting the issuance of the Warrant Shares to or resale of the Warrant Shares by the Warrantholder or (B) the Warrant Shares are eligible for resale by the Warrantholder without volume or manner of sale limitations pursuant to Rule 144 (assuming cashless exercise of this Warrant, if then permitted), and otherwise by book-entry form or, if requested by the Warrantholder, a physical delivery of a stock certificate, registered in the Company’s share register in the name of the Warrantholder or its designee, for the number of Warrant Shares to which the Warrantholder is entitled pursuant to such exercise to the address specified by the Warrantholder in the Notice of Exercise by the date that is the earlier of (i) two (2) Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period after the delivery to the Company of the Notice of Exercise (such date, the “Warrant Share Delivery Date”). Upon delivery of the Notice of Exercise, the Warrantholder shall be deemed for all corporate purposes to have become the holder of record of the Warrant Shares with respect to which this Warrant has been exercised, irrespective of the date of delivery of the Warrant Shares, provided that payment of the aggregate Strike Price (other than in the case of a cashless exercise) is received within the earlier of (i) two (2) Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period following delivery of the Notice of Exercise. The Company agrees to maintain a transfer agent that is a participant in the Fast Automated Security Transfer program so long as this Warrant remains outstanding and exercisable. As used herein, “Standard Settlement Period” means the standard settlement period, expressed in a number of Trading Days, on the Company’s primary Trading Market with respect to the Common Stock as in effect on the date of delivery of the Notice of Exercise.

 

  (ii)

Delivery of New Warrants Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at the request of a Warrantholder and upon surrender of this Warrant, at the time of delivery of the Warrant Shares, deliver to the Warrantholder a new Warrant evidencing the rights of the Warrantholder to purchase the unpurchased Warrant Shares called for by this Warrant, which new Warrant shall in all other respects be identical with this Warrant.

 

10


  (iii)

Rescission Rights. If the Company fails to cause the Transfer Agent to transmit to the Warrantholder the Warrant Shares pursuant to Section 2(d)(i) by the Warrant Share Delivery Date, then the Warrantholder will have the right to rescind such exercise, including in the event of a Buy-In, as described in Section 2(d)(iv) below.

 

  (iv)

Compensation for Buy-In on Failure to Timely Deliver Warrant Shares Upon Exercise. In addition to any other rights available to the Warrantholder, if the Company fails to cause the Transfer Agent to transmit to the Warrantholder the Warrant Shares in accordance with the provisions of Section 2(d)(i) above pursuant to an exercise on or before the Warrant Share Delivery Date, and if after such date the Warrantholder is required by its broker to purchase (in an open market transaction or otherwise) or the Warrantholder’s brokerage firm otherwise purchases, Shares of Common Stock to deliver in satisfaction of a sale by the Warrantholder of the Warrant Shares which the Warrantholder anticipated receiving upon such exercise (a “Buy-In”), then the Company shall (A) pay in cash to the Warrantholder the amount, if any, by which (x) the Warrantholder’s total purchase price (including brokerage commissions, if any) for the Shares of Common Stock so purchased exceeds (y) the amount obtained by multiplying (1) the number of Warrant Shares that the Company was required to deliver to the Warrantholder in connection with the exercise at issue times (2) the price at which the sell order giving rise to such purchase obligation was executed, and (B) at the option of the Warrantholder (pursuant to notice to be sent by the Warrantholder to the Company within ten (10) calendar days following the Warrant Share Delivery Date; if such notice is not provided by that date, the Company shall instead have the right to decide), either reinstate the portion of this Warrant and equivalent number of Warrant Shares for which such exercise was not honored (in which case such exercise shall be deemed rescinded) or deliver to the Warrantholder the number of Shares of Common Stock that would have been issued had the Company timely complied with its exercise and delivery obligations hereunder. For example, if the Warrantholder purchases Common Stock having a total purchase price of $11,000 to cover a Buy-In with respect to an attempted exercise of Shares of Common Stock with an aggregate sale price giving rise to such purchase obligation of $10,000, under clause (A) of the immediately preceding sentence the Company shall be required to pay the Warrantholder $1,000. The Warrantholder shall provide the Company written notice indicating the amounts payable to the Warrantholder in respect of the Buy-In and, upon request of the Company, evidence of the amount of such loss. Nothing herein shall limit a Warrantholder’s right to pursue any other remedies available to it hereunder, at law or in equity including, without limitation, a decree of specific performance and/or injunctive relief with respect to the Company’s failure to timely deliver Shares of Common Stock upon exercise of this Warrant as required pursuant to the terms hereof.

 

11


  (v)

No Fractional Shares or Scrip. No fractional Shares or scrip representing fractional Shares shall be issued upon the exercise of this Warrant. As to any fraction of a Share which the Warrantholder would otherwise be entitled to purchase upon such exercise, the Company shall, at its election, either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the Strike Price or round up to the next whole Share.

 

  (vi)

Charges, Taxes and Expenses. Issuance of Warrant Shares shall be made without charge to the Warrantholder for any issue or transfer tax or other incidental expense in respect of the issuance of such Warrant Shares, all of which taxes and expenses shall be paid by the Company, and such Warrant Shares shall be issued in the name of the Warrantholder or in such name or names as may be directed by the Warrantholder; provided, however, that in the event that Warrant Shares are to be issued in a name other than the name of the Warrantholder, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form substantially in the form attached hereto as Exhibit B, duly executed by the Warrantholder and transferee and the Company may require, as a condition thereto, the payment of a sum sufficient to reimburse it for any transfer tax incidental thereto. The Company shall pay all Transfer Agent fees required for same-day processing of any Notice of Exercise and all fees to the Depository Trust Company (or another established clearing corporation performing similar functions) required for same-day electronic delivery of the Warrant Shares.

 

  (vii)

Closing of Books. The Company will not close its stockholder books or records in any manner which prevents the timely exercise of this Warrant, pursuant to the terms hereof.

 

  (e)

Warrantholders Exercise Limitations. The Company shall not effect any exercise of this Warrant, and a Warrantholder shall not have the right to exercise any portion of this Warrant, pursuant to Section 2 or otherwise, to the extent that after giving effect to such issuance after exercise as set forth on the applicable Notice of Exercise, the Warrantholder (together with the Warrantholder’s Affiliates, and any other Persons acting as a group together with the Warrantholder or any of the Warrantholder’s Affiliates (such Persons, “Attribution Parties”)), would beneficially own in excess of the Beneficial Ownership Limitation. For purposes of the foregoing sentence, the number of Shares of Common Stock beneficially owned by the Warrantholder and its Affiliates and Attribution Parties shall include the number of Shares of Common Stock issuable upon exercise of this Warrant with respect to which such determination is being made, but shall exclude the number of Shares of Common Stock which would be issuable upon (i) exercise of the remaining, nonexercised portion of this Warrant beneficially owned by the Warrantholder or any of its Affiliates or Attribution Parties and (ii) exercise or conversion of the unexercised or nonconverted portion of any other securities of the Company (including, without limitation, Convertible Securities) subject to a limitation on conversion or exercise analogous to the limitation contained herein

 

12


  beneficially owned by the Warrantholder or any of its Affiliates or Attribution Parties. Except as set forth in the preceding sentence, for purposes of this Section 2(e), beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder, it being acknowledged by the Warrantholder that the Company is not representing to the Warrantholder that such calculation is in compliance with Section 13(d) of the Exchange Act and the Warrantholder is solely responsible for any schedules required to be filed in accordance therewith. To the extent that the limitation contained in this Section 2(e) applies, the determination of whether this Warrant is exercisable (in relation to other securities owned by the Warrantholder together with any Affiliates and Attribution Parties) and of which portion of this Warrant is exercisable shall be in the sole discretion of the Warrantholder, and the submission of a Notice of Exercise shall be deemed to be the Warrantholder’s determination of whether this Warrant is exercisable (in relation to other securities owned by the Warrantholder together with any Affiliates and Attribution Parties) and of which portion of this Warrant is exercisable, in each case subject to the Beneficial Ownership Limitation, and the Company shall have no obligation to verify or confirm the accuracy of such determination. In addition, a determination as to any group status as contemplated above shall be determined in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section 2(e), in determining the number of outstanding Shares of Common Stock, a Warrantholder may rely on the number of outstanding Shares of Common Stock as reflected in (A) the Company’s most recent periodic or annual report filed with the SEC, as the case may be, (B) a more recent public announcement by the Company or (C) a more recent written notice by the Company or the Transfer Agent setting forth the number of Shares of Common Stock outstanding. Upon the written or oral request of a Warrantholder, the Company shall within one (1) Trading Day confirm orally and in writing to the Warrantholder the number of Shares of Common Stock then outstanding. In any case, the number of outstanding Shares of Common Stock shall be determined after giving effect to the conversion or exercise of securities of the Company, including this Warrant, by the Warrantholder or its Affiliates or Attribution Parties since the date as of which such number of outstanding Shares of Common Stock was reported. The “Beneficial Ownership Limitation” shall be 4.99% of the number of Shares of Common Stock outstanding immediately after giving effect to the issuance of Shares of Common Stock issuable upon exercise of this Warrant. The Warrantholder, upon notice to the Company, may increase or decrease the Beneficial Ownership Limitation provisions of this Section 2(e), provided that the Beneficial Ownership Limitation in no event exceeds 19.99% of the number of the Shares of Common Stock outstanding immediately after giving effect to the issuance of Shares of Common Stock upon exercise of this Warrant held by the Warrantholder and the provisions of this Section 2(e) shall continue to apply. Any increase in the Beneficial Ownership Limitation will not be effective until the sixty first (61st) calendar day after such notice is delivered to the Company. The provisions of this paragraph shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this Section 2(e) to correct this paragraph (or any portion hereof) which may be defective or inconsistent with the intended Beneficial Ownership Limitation herein contained or to make changes or supplements necessary or desirable to properly give effect to such limitation. The limitations contained in this paragraph shall apply to a successor holder of this Warrant.

 

13


Notwithstanding anything to the contrary in this Warrant or otherwise, (i) if and as required, prior to obtaining stockholder approval as required by the rules of the Nasdaq Stock Market, LLC, the Company shall not be required to effect any exercise of this Warrant, and (ii) a Warrantholder shall not have the right to exercise any portion of this Warrant, pursuant to this Section 2 or otherwise, if the Company determines in good faith that such exercise would result in requiring a vote of the Company’s stockholders pursuant to the applicable rules of the Trading Market, including, without limitation because such exercise (1) would result in the Warrantholder and its Affiliates and Attribution Parties beneficially owning (x) in excess of 19.99% of the number of Shares of Common Stock outstanding immediately after giving effect to the issuance of Shares of Common Stock upon exercise of this Warrant and (y) the largest ownership position in the Company, or (2) would otherwise result in a “change of control” of the Company as defined under the rules of the Trading Market.

Section 3. CERTAIN ADJUSTMENTS.

 

  (a)

Stock Dividends; Splits; Combinations; Reclassifications. If the Company, at any time while this Warrant is outstanding: (i) pays a stock dividend or otherwise makes a distribution or distributions on Shares of its Common Stock or any Convertible Securities (which, for avoidance of doubt, shall not include any Shares of Common Stock issued by the Company upon exercise of this Warrant), (ii) subdivides (by any stock split, recapitalization, or otherwise) outstanding Shares of Common Stock into a larger number of Shares, (iii) combines (including by way of reverse stock split) outstanding Shares of Common Stock into a smaller number of Shares or (iv) issues by reclassification of Shares of Common Stock any Shares of capital stock of the Company; then in each case the Strike Price shall be multiplied by a fraction of which the numerator shall be the Shares of Common Stock outstanding immediately before such event and of which the denominator shall be the Shares of Common Stock outstanding immediately after such event, and the number of Shares issuable upon exercise of this Warrant shall be proportionately adjusted such that the aggregate Strike Price of this Warrant shall remain unchanged, provided that the Strike Price per Share shall in any case be no lower than the par value of the Common Stock. Any adjustment made pursuant to this Section 3(a) shall become effective immediately after the record date for the determination of stockholders entitled to receive such dividend or distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or re-classification. The provisions of this Section 3(a) shall similarly apply to successive stock dividends, combinations, reclassifications, or other similar events.

 

14


  (b)

Voluntary Adjustment By Company. The Company may at any time during the term of this Warrant reduce the then current Strike Price of this Warrant to any amount and for any period of time deemed appropriate by the Board of Directors with the prior written consent of the Warrantholder, provided that the Strike Price per underlying Share of Common Stock shall be no lower than the par value of the Common Stock as of the relevant time.

 

  (c)

Fundamental Transaction. If, at any time while this Warrant is outstanding, (i) the Company, directly or indirectly, in one or more related transactions effects any merger or consolidation of the Company with or into another Person, (ii) the Company, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer, tender offer or exchange offer (whether by the Company or another Person) is completed pursuant to which holders of Shares of Common Stock are permitted to sell, tender or exchange their Shares for other securities, cash or property and has been accepted by the holders of 50% or more of the outstanding Shares of Common Stock or 50% or more of the voting power of the Common Stock, (iv) the Company, directly or indirectly, in one or more related transactions effects any reclassification, reorganization or recapitalization of the Shares of Common Stock or any compulsory share exchange pursuant to which the Shares of Common Stock are effectively converted into or exchanged for other securities, cash or property, or (v) the Company, directly or indirectly, in one or more related transactions consummates a stock or share purchase agreement or other business combination (including, without limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with another Person or group of Persons whereby such other Person or group acquires more than 50% of the outstanding Shares of Common Stock or 50% or more of the voting power of the Common Stock (in each case, not including any Shares of Common Stock held by the other Person or other Persons making or party to, or associated or affiliated with the other Persons making or party to, such stock or share purchase agreement or other business combination) (each a “Fundamental Transaction”), in each case, other than in connection with an Acquisition which shall be governed by Section 3(d), then, upon any subsequent exercise of this Warrant, the Warrantholder shall have the right to receive, for each Warrant Share that would have been issuable upon such exercise immediately prior to the occurrence of such Fundamental Transaction, at the option of the Warrantholder (without regard to any limitation in Section 2(e) on the exercise of this Warrant), the number of Shares of Common Stock of the successor or acquiring corporation or of the Company, if it is the surviving corporation, and any additional consideration (the “Alternate Consideration”) receivable as a result of such Fundamental Transaction by a holder of the number of Shares of Common Stock for which this Warrant is exercisable immediately prior to such Fundamental Transaction (without regard to any limitation in Section 2(e) on the exercise of this Warrant). For purposes of any such exercise, the determination of the Strike Price shall be appropriately adjusted to apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one Share of Common Stock in such Fundamental Transaction, and the Company shall apportion the

 

15


  Strike Price among the Alternate Consideration in a reasonable manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Shares of Common Stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Warrantholder shall be given the same choice as to the Alternate Consideration it receives upon any exercise of this Warrant following such Fundamental Transaction. Notwithstanding anything to the contrary, in the event of a Fundamental Transaction other than in connection with an Acquisition, which shall be governed by Section 3(d), the Company or any Successor Entity shall, at the Warrantholder’s option, exercisable at any time concurrently with, or within thirty (30) calendar days after, the consummation of the Fundamental Transaction (or, if later, the date of the public announcement of the applicable Fundamental Transaction), purchase this Warrant from the Warrantholder by paying to the Warrantholder an amount of cash equal to the Black Scholes Value of the remaining unexercised portion of this Warrant on the date of the consummation of such Fundamental Transaction; provided, however, that, if the Fundamental Transaction is not within the Company’s control, including not approved by the Board of Directors, Warrantholder shall only be entitled to receive from the Company or any Successor Entity the same type or form of consideration (and in the same proportion), at the Black Scholes Value of the unexercised portion of this Warrant, that is being offered and paid to the holders of Common Stock of the Company in connection with the Fundamental Transaction, whether that consideration be in the form of cash, stock or any combination thereof, or whether the holders of Common Stock are given the choice to receive from among alternative forms of consideration in connection with the Fundamental Transaction; provided, further, that if holders of Common Stock of the Company are not offered or paid any consideration in such Fundamental Transaction, such holders of Common Stock will be deemed to have receive common stock of the Successor Entity (which Successor Entity may be the Company following such Fundamental Transaction) in such Fundamental Transaction. “Black Scholes Value” means the value of this Warrant based on the Black-Scholes Option Pricing Model obtained from the “OV” function on Bloomberg, L.P. (“Bloomberg”) determined as of the day of consummation of the applicable contemplated Fundamental Transaction for pricing purposes and reflecting (A) a risk-free interest rate corresponding to the U.S. Treasury rate for a period equal to the time between the date of the public announcement of the applicable Fundamental Transaction and the Termination Date, (B) an expected volatility equal to the greater of 100% and the one hundred (100) day volatility obtained from the “HVT” function on Bloomberg (determined utilizing a three hundred and sixty-five (365) day annualization factor) as of the Trading Day immediately following the public announcement of the applicable contemplated Fundamental Transaction, (C) the underlying price per Share used in such calculation shall be the greater of (i) the sum of the price per Share being offered in cash, if any, plus the value of any non-cash consideration, if any, being offered in such Fundamental Transaction and (ii) the highest VWAP during the period beginning on the Trading Day immediately preceding the public announcement of the applicable contemplated Fundamental Transaction (or the consummation of the

 

16


  applicable Fundamental Transaction, if earlier) and ending on the Trading Day of the Warrantholder’s request pursuant to this Section 3(c), (D) a remaining option time equal to the time between the date of the public announcement of the applicable contemplated Fundamental Transaction and the Termination Date, and (E) a zero cost of borrow. The payment of the Black Scholes Value will be made by wire transfer of immediately available funds (or such other consideration) within five (5) Business Days of the Warrantholder’s election (or, if later, on the date of consummation of the Fundamental Transaction). The Company shall cause any successor entity in a Fundamental Transaction in which the Company is not the survivor (the “Successor Entity”) to assume in writing all of the obligations of the Company under this Warrant in accordance with the provisions of this Section 3(c) pursuant to written agreements in form and substance reasonably satisfactory to the Warrantholder prior to such Fundamental Transaction and shall, at the option of the Warrantholder, deliver to the Warrantholder in exchange for this Warrant a security of the Successor Entity evidenced by a written instrument substantially similar in form and substance to this Warrant which is exercisable for a corresponding number of shares of capital stock of such Successor Entity (or its parent entity) equivalent to the Shares of Common Stock acquirable and receivable upon exercise of this Warrant (without regard to any limitations on the exercise of this Warrant) prior to such Fundamental Transaction, and with an exercise price which applies the exercise price hereunder to such shares of capital stock (but taking into account the relative value of the Shares of Common Stock pursuant to such Fundamental Transaction and the value of such shares of capital stock, such number of shares of capital stock and such exercise price being for the purpose of protecting the economic value of this Warrant immediately prior to the consummation of such Fundamental Transaction), and which is reasonably satisfactory in form and substance to the Warrantholder. Upon the occurrence of any such Fundamental Transaction, the Successor Entity shall succeed to, and be substituted for (so that from and after the date of such Fundamental Transaction, the provisions of this Warrant referring to the “Company” shall refer instead to the Successor Entity), and may exercise every right and power of the Company and shall assume all of the obligations of the Company under this Warrant with the same effect as if such Successor Entity had been named as the Company herein. Notwithstanding anything in this Section 3(c) to the contrary, if the Company is permitted to exercise the Call Option with respect to a Fundamental Transaction and so exercises the Call Option, this Section 3(c) shall not apply to such Fundamental Transaction and the provisions of Section 5 shall instead apply.

 

  (d)

Treatment of Warrant Upon Acquisition of Company.

 

  (i)

Notwithstanding anything in Section 3(c) to the contrary, in the event of any Fundamental Transaction in which all of the Shares underlying the Warrant Shares, including the outstanding Common Stock and/or such other shares or securities issued pursuant to the adjustment provision set forth in Section 3(c) is converted into or exchanged for only the right to receive cash, which rights may include any future payments, earnouts or contingent value payment that is payable in cash or otherwise has a predetermined cash value

 

17


  (an “Acquisition” and such amount of cash, the “Cash Consideration”), (1) the Company shall provide the Warrantholder at least ten (10) Business Days’ advance written notice of the anticipated closing of such Acquisition, (2) subject to any other limitations on exercise in this Warrant, the Warrantholder shall have the right to exercise this Warrant until the day prior to the closing of the Acquisition, and (3) if the Warrantholder shall not have elected to exercise this Warrant in full, any outstanding Warrant Shares shall be treated in accordance with Section 3(d)(ii) below.

 

  (ii)

If, immediately prior to the Acquisition, the Cash Consideration payable upon conversion or exchange of one Warrant Share would be greater than the applicable Strike Price in effect on such date, then effective upon the consummation of the Acquisition, this Warrant shall automatically be deemed, on and as of such date, to be converted into only the right to receive an amount in cash equal to (x) the excess of the Cash Consideration payable upon conversion or exchange of one Warrant Share over the Strike Price in effect on such date, multiplied by (y) the number of Warrant Shares for which this Warrant shall not have previously been exercised. If, immediately prior to the Acquisition, the Cash Consideration payable upon conversion or exchange of one Warrant Share would be less than the applicable Strike Price in effect on such date, then effective upon the consummation of the Acquisition, this Warrant shall automatically be deemed on and as of such date to be cancelled for no consideration. To the extent that the Cash Consideration includes any future or contingent payment, the fair market value of such future or contingent payment for the purpose of the determination of the Cash Consideration amount under this Section 3(d)(ii) shall be determined in good faith by the Company’s Board of Directors.

 

  (iii)

Notwithstanding anything in this Section 3(d) to the contrary, if the Company is permitted to exercise the Call Option with respect to an Acquisition and so exercises the Call Option, this Section 3(d) shall not apply to such Acquisition and the provisions of Section 5 shall instead apply.

 

  (e)

Calculations. All calculations under this Section 3 shall be made to the nearest cent or the nearest 1/100th of a Share, as the case may be. For purposes of this Section 3, the number of Shares of Common Stock deemed to be issued and outstanding as of a given date shall be the sum of the number of Shares of Common Stock (excluding treasury Shares, if any) issued and outstanding.

 

18


  (f)

Notice to Warrantholder.

 

  (i)

Adjustment to Strike Price. Upon the occurrence of any adjustment pursuant to this Section 3, the Company at its expense shall promptly deliver to the Warrantholder a written notice setting forth the adjustment, including a statement of the adjusted Strike Price and adjusted number of Warrant Shares, describing the transactions giving rise to such adjustments and the facts upon which such adjustment is based. The Company shall, upon written request from the Warrantholder, furnish the Warrantholder with a certificate of its Chief Financial Officer or Chief Executive Officer, including computations of such adjustment and the Strike Price, class, and number of Shares in effect upon the date of such adjustment.

 

  (ii)

Notice to Allow Exercise by Holder. Upon the occurrence of any of the scenarios set forth in Section 3(a) through Section 3(d), unless otherwise provided in such section, then, in each case, the Company shall cause to be delivered by email to the Warrantholder at its last email address as it shall appear upon the Warrant Register of the Company, at least ten (10) calendar days prior to the applicable record or effective date hereinafter specified, a notice stating (x) the date on which a record is to be taken for the purpose of any issuance, dividend, distribution, redemption, rights or warrants, or if a record is not to be taken, the date as of which the holders of the Shares of Common Stock of record to be entitled to such issuance, dividend, distributions, redemption, rights or warrants are to be determined or (y) the date on which any reclassification, consolidation, merger, sale, transfer or stock exchange is expected to become effective or close, and the date as of which it is expected that holders of the Shares of Common Stock of record shall be entitled to exchange their Shares of Common Stock for securities, cash or other property deliverable upon such reclassification, consolidation, merger, sale, transfer or stock exchange; provided that the failure to deliver such notice or any defect therein or in the delivery thereof shall not affect the validity of the corporate action required to be specified in such notice and provided, further that no notice shall be required if the information is disseminated in a press release or document filed with the SEC. To the extent that any notice provided in this Warrant constitutes, or contains, material, non-public information regarding the Company or any of the Subsidiaries, the Company shall simultaneously file such notice with the SEC pursuant to a Current Report on Form 8-K. The issuance of a press release or the filing of a Form 8-K or other suitable filing with the SEC shall satisfy this notice requirement. The Warrantholder shall remain entitled to exercise this Warrant during the period commencing on the date of such notice to the effective date of the event triggering such notice except as may otherwise be expressly set forth herein.

Section 4. TRANSFER OF WARRANT.

 

  (a)

Transferability. Subject to compliance with any Applicable Laws, including applicable securities laws and the conditions set forth in Section 4(c) hereof, this Warrant and all rights hereunder are transferable, in whole or in part, following the delivery of a notice by the Warrantholder to the Company which specifies the identity of the purchaser or transferee, upon surrender of this Warrant at the principal office of the Company or its designated agent, together with a written assignment of this Warrant substantially in the form attached hereto duly executed

 

19


  by the Warrantholder or its agent or attorney and funds sufficient to pay any transfer taxes payable upon the making of such transfer. Upon such surrender and, if required, such payment, the Company shall execute and deliver a new Warrant or Warrants in the name of the assignee or assignees, as applicable, and in the denomination or denominations specified in such instrument of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not so assigned, and this Warrant shall promptly be cancelled. Notwithstanding anything herein to the contrary, the Warrantholder shall not be required to physically surrender this Warrant to the Company unless the Warrantholder has assigned this Warrant in full, in which case, the Warrantholder shall surrender this Warrant to the Company within three (3) Trading Days of the date on which the Warrantholder delivers an assignment form to the Company assigning this Warrant in full. This Warrant, if properly assigned in accordance herewith, may be exercised by a new holder for the purchase of Warrant Shares without having a new Warrant issued.

 

  (b)

Warrant Register. The Company shall register this Warrant, upon records to be maintained by the Company for that purpose (the “Warrant Register”), in the name of the record Warrantholder hereof from time to time. The Company may deem and treat the registered Warrantholder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any distribution to the Warrantholder, and for all other purposes, absent actual notice to the contrary.

 

  (c)

Transfer Restrictions. If, at the time of the surrender of this Warrant in connection with any permitted transfer of this Warrant, the transfer of this Warrant shall not be either (i) registered pursuant to an effective registration statement under the Securities Act and under applicable state securities or blue sky laws or (ii) eligible for resale without volume or manner-of-sale restrictions or current public information requirements pursuant to Rule 144, the Company may require, as a condition of allowing such transfer, that the Warrantholder or transferee of this Warrant, as the case may be, comply with the provisions of Section 4(e).

 

  (d)

Representation by the Warrantholder. The Warrantholder, by the acceptance hereof, represents and warrants that it is acquiring this Warrant and, upon any exercise hereof, will acquire the Warrant Shares issuable upon such exercise, for its own account and not with a view to or for distributing or reselling such Warrant Shares or any part thereof in violation of the Securities Act or any applicable state securities law, except pursuant to sales registered or exempted under the Securities Act.

 

  (e)

Removal of Legends.

  (i)

In connection with any sale, assignment, transfer or other disposition of the Warrant Shares by a Warrantholder pursuant to Rule 144 or pursuant to any other exemption under the Securities Act such that the purchaser acquires freely tradable shares and upon compliance by the Warrantholder with the requirements of this Warrant, if requested by the Warrantholder by notice

 

20


  to the Company, the Company shall request the Transfer Agent to remove any restrictive legends related to the book entry account holding such Shares, including the Warrant Register, and make a new, unlegended entry for such book entry Shares sold or disposed of without restrictive legends as soon as reasonably practicable following any such request therefor from such Warrantholder, provided that the Company has timely received from the Warrantholder customary representations and other documentation reasonably acceptable to the Company in connection therewith. The Company shall be responsible for the fees of its Transfer Agent and its legal counsel associated with such legend removal.

 

  (ii)

Subject to receipt from the Warrantholder by the Company and the Transfer Agent of customary representations and other documentation reasonably acceptable to the Company and the Transfer Agent in connection therewith, upon the earliest of such time as the Warrant Shares (i) have been registered under the Securities Act pursuant to an effective registration statement or (ii) have been sold pursuant to Rule 144, the Company shall, in accordance with the provisions of this Section 4(e)(ii) and as soon as reasonably practicable following any request therefor from a Warrantholder accompanied by such customary and reasonably acceptable documentation referred to above, (A) deliver to the Transfer Agent irrevocable instructions that the Transfer Agent shall make a new, unlegended entry for such book entry Shares, and (B) cause its counsel to deliver to the Transfer Agent one or more opinions to the effect that the removal of such legends in such circumstances may be effected under the Securities Act if required by the Transfer Agent to effect the removal of the legend in accordance with the provisions of this Warrant.

Section 5. CALL OPTION.

 

  (a)

The Warrantholder irrevocably grants the Call Option to the Company on the terms set forth in this Warrant. The Call Option may be exercised by the Company at its sole discretion in relation to this Warrant (i) upon a Change of Control Event, at any time from 15 (fifteen) Business Days prior to (but conditional on completion thereof) until 15 (fifteen) Business Days after the Change of Control Event, (ii) in the case of a Qualifying Tender Offer, no less than 15 (fifteen) Business Days prior the completion of a Qualifying Tender Offer (and conditional on completion thereof), or (iii) in the case of a Transformational Transaction, at any time from 15 (fifteen) Business Days prior to (but conditional on completion thereof) until 15 (fifteen) Business Days after the Transformational Transaction. In the event that a Material Press Release has been made public by the Company, the Call Option may not be exercised by the Company until at least 5 (five) Business Days following the date of such Material Press Release.

 

21


  (b)

The Company may exercise the Call Option by serving upon the Warrantholder a draft Company Call Option Notice, which upon being served is irrevocable except with the consent of the Warrantholder. The Company shall specify the aggregate Call Option Price in the draft Company Call Option Notice.

 

  (c)

The Warrantholder shall have the Call Option Objection Period to agree or dispute the Company’s calculation of the aggregate Call Option Price. If, by the end of the Call Option Objection Period:

 

  (i)

the Warrantholder has not delivered a notice in writing to the Company disputing the aggregate Call Option Price, the Warrantholder shall be deemed to have agreed the aggregate Call Option Price specified in the draft Company Call Option Notice, and the draft Company Call Option Notice shall automatically become final and binding on the Company and the Warrantholder; or

 

  (ii)

to the extent that the Warrantholder has delivered a notice in writing to the Company disputing the aggregate Call Option Price, either or both of the Warrantholder and the Company shall refer the matter to the Expert for determination in accordance with Exhibit D.

 

  (d)

Within five (5) Business Days of the Expert’s decision, the Company must deliver to the Warrantholder a revised Company Call Option Notice (together with the Supporting Calculations) incorporating such adjustments, if any, as have been determined by the Expert, provided that the Company shall have the option to withdraw the Company Call Option Notice and cancel the proposed exercise of the Call Option if the aggregate Call Option Price is greater than 110% of the aggregate estimated Call Option Price included in the Company Call Option Notice. The revised Company Call Option Notice will supersede the initial draft Company Call Option Notice and will be final and binding on the Parties from the date of its delivery to the Warrantholder provided that it reflects the changes that have been determined by the Expert.

 

  (e)

Within twenty (20) Business Days of the Company Call Option Notice becoming final and binding in accordance with this Section 5, the Company must pay the aggregate Call Option Price in respect of the relevant portion of this Warrant in cash by electronic transfer of funds for same day value to such bank account as the Warrantholder has specified to the Company in advance in writing, whereupon the relevant portion of this Warrant will be cancelled and of no further force and effect.

Section 6. MISCELLANEOUS.

 

  (a)

No Rights as Stockholder Until Exercise. This Warrant does not entitle the Warrantholder to any voting rights, dividends or other rights as a stockholder of the Company prior to the exercise hereof as set forth in Section 2(d)(i).

 

22


  (b)

Loss, Theft, Destruction or Mutilation of Warrant. The Company covenants that upon receipt by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant or any stock certificate relating to the Warrant Shares, and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which, in the case of this Warrant, shall not include the posting of any bond), and upon surrender and cancellation of such Warrant or stock certificate, if mutilated, the Company will make and deliver a new Warrant or stock certificate of like tenor and dated as of such cancellation, in lieu of such Warrant or stock certificate.

 

  (c)

Business Day. Any payment under this Warrant which is due to be made on a day that is not a Business Day shall be made on the next Business Day in the same calendar month (if there is one) or the preceding Business Day (if there is not).

 

  (d)

Authorized Shares. The Company covenants that, during the period this Warrant is outstanding, it will reserve from its authorized and unissued Shares of Common Stock a sufficient number of Shares to provide for the issuance of the Warrant Shares upon the exercise of any purchase rights under this Warrant. The Company further covenants that its issuance of this Warrant shall constitute full authority to its officers who are charged with the duty of issuing the necessary Warrant Shares upon the exercise of the purchase rights under this Warrant. The Company will take all such reasonable action as may be necessary to assure that such Warrant Shares may be issued as provided herein without violation of any Applicable Law or regulation, or of any requirements of the Trading Market upon which the Shares of Common Stock may be listed. The Company covenants that all Warrant Shares which may be issued upon the exercise of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant and payment for such Warrant Shares in accordance herewith, be duly authorized, validly issued, fully paid and nonassessable and free from all taxes and Encumbrances created by the Company in respect of the issue thereof (other than taxes in respect of any transfer occurring contemporaneously with such issue or Encumbrances imposed by the Warrantholder).

Except and to the extent as waived or consented to by the Warrantholder, the Company shall not by any action, including, without limitation, amending its Charter or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such actions as may be necessary or appropriate to protect the rights of Warrantholder as set forth in this Warrant against impairment. Without limiting the generality of the foregoing, the Company will (i) not increase the par value of any Warrant Shares above the amount payable therefor upon such exercise immediately prior to such increase in par value, (ii) take all such action as may be necessary or appropriate in order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant and (iii) use commercially reasonable efforts to obtain all such authorizations, exemptions or consents from any public regulatory body having jurisdiction thereof, as may be, necessary to enable the Company to perform its obligations under this Warrant.

 

23


Before taking any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the Strike Price, the Company shall obtain all such authorizations or exemptions thereof, or consents thereto, as may be necessary from any public regulatory body or bodies having jurisdiction thereof.

 

  (e)

Governing Law; Jurisdiction; Waiver of Trial by Jury.

 

  (i)

This Warrant and any non-contractual obligations arising out of or in connection with it shall be governed by and construed in accordance with the laws of the State of New York, without regard to any to principles of conflicts or choice of law in the State of New York or in any other state.

 

  (ii)

Each of the parties hereto irrevocably and unconditionally submits, for itself and its property, to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan, in any action or proceeding arising out of or relating to this Warrant for recognition or enforcement of any judgment, and each of the parties hereto irrevocably and unconditionally agrees, to the fullest extent permitted by Applicable Law, that all claims in respect of any such action or proceeding may be heard and determined in such state or federal court sitting in the City of New York in the Borough of Manhattan. Each of the parties hereto agrees that a final judgment in any such action or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by law.

 

  (iii)

EACH OF THE PARTIES TO THIS WARRANT IRREVOCABLY AND UNCONDITIONALLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY RIGHT IT MAY HAVE TO TRIAL BY JURY IN RESPECT OF ANY LEGAL ACTION OR LITIGATION ARISING OUT OF, OR IN CONNECTION WITH, OR RELATING TO, THIS WARRANT OR THE TRANSACTIONS CONTEMPLATED HEREBY, IN EACH CASE WHETHER NOW EXISTING OR HEREAFTER ARISING, AND WHETHER IN CONTRACT, TORT, EQUITY, OR OTHERWISE.

 

  (f)

Restrictions Upon Resale. The Warrantholder acknowledges that the Warrant Shares acquired upon the exercise of this Warrant, if not registered and the Warrantholder does not utilize cashless exercise, will have restrictions upon resale imposed by state and federal securities laws.

 

  (g)

Waiver. Failure to exercise, or a delay in exercising, a right or remedy provided by this Warrant or by law does not constitute a waiver of the right or remedy or a waiver of other rights or remedies. No single or partial exercise of a right or remedy provided by this Warrant or by law prevents the further exercise of the right or remedy or the exercise of another right or remedy. A waiver of a breach of this Warrant does not constitute a waiver of a subsequent or prior breach of this Warrant.

 

24


  (h)

Notices. Notices and other communications given under or in connection with this Warrant addressed to a party hereto shall be made in writing to either (i) the address or (ii) the e-mail address (and the department for whose attention the communication is to be made), each as set out below, or to such other address or e-mail address as a party previously notifies to the other party in writing:

 

  (i)

For the Warrantholder:

 

Attention:    OPS/EGPF/2-EGILS/[LSB]/[SI]
Address:    The European Investment Bank
   100 boulevard Konrad Adenauer
   L-2950 Luxembourg

With a copy to (which shall not constitute notice):

 

Attention:    Matthew K. Warner
   Partner
Address:    Clifford Chance US LLP
   Two Manhattan West
   375 9th Avenue
   New York, NY 10019
   USA
E-mail address:    matthew.warner@cliffordchance.com

 

  (ii)

For the Company:

 

Attention:    Mai-Britt Zocca
Address:    IO Biotech, Inc.
   Ole Maaløes Vej 3
   DKK-220 Copenhagen N
   Denmark

With copies to (which shall not constitute notice):

 

Attention:    Devin Smith
   General Counsel
Address:    IO Biotech, Inc.
   430 E 29th St
   Suite 940
   New York, NY 10016
   USA

 

25


and:   
Attention:    Frank Rahmani
Address:    Sidley Austin LLP
   1001 Page Mill Rd., Building 1
   Palo Alto, California 94304
   USA
E-mail address:    frahmani@sidley.com

 

  (iii)

Changes to notice address. Each party hereto shall promptly notify the other party in writing of any change in its communication details.

 

  (iv)

Language for notices. Any notice or other communication given under this Warrant must be in writing and in the English language.

 

  (v)

Notice setting deadlines. Notices and other communications, for which fixed periods are laid down in this Warrant or which themselves fix periods binding on the addressee, may be made by hand delivery or registered letter with acknowledgement of receipt. Such notices and communications shall be deemed to have been received by the relevant party on the date of delivery.

 

  (vi)

Other notices. Other notices and communications may be made may be made by hand delivery, registered letter, or e-mail, which shall be effective upon confirmation of receipt.

 

  (vii)

Evidence of signing authority. Notices issued by the Company pursuant to any provision of this Warrant shall, where required by the Warrantholder, be delivered to the Warrantholder together with satisfactory evidence of the authority of the person or persons authorized to sign such notice on behalf of the Company and the authenticated specimen signature of such person or persons.

 

  (i)

Limitation of Liability. No provision hereof, in the absence of any affirmative action by the Warrantholder to exercise this Warrant to purchase Warrant Shares, and no enumeration herein of the rights or privileges of the Warrantholder, shall give rise to any liability of the Warrantholder for the purchase price of any Shares of Common Stock or as a stockholder of the Company, whether such liability is asserted by the Company or by creditors of the Company.

 

  (j)

Remedies. The Warrantholder, in addition to being entitled to exercise all rights granted by Applicable Law, including recovery of damages, will be entitled to specific performance of its rights under this Warrant. The Company agrees that monetary damages would not be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Warrant and hereby agrees to waive and not to assert the defense in any action for specific performance that a remedy at law would be adequate.

 

26


  (k)

Successors and Assigns. Subject to Applicable Law, including applicable securities laws, this Warrant and the rights and obligations evidenced hereby shall inure to the benefit of and be binding upon the successors and permitted assigns of the Company and the successors and permitted assigns of Warrantholder. The provisions of this Warrant are intended to be for the benefit of any Warrantholder from time to time of this Warrant and shall be enforceable by the Warrantholder or holder of Warrant Shares.

 

  (l)

Amendment. Any amendment to this Warrant shall be made in writing and shall be signed by the parties hereto. For the avoidance of doubt, any accession to this Warrant pursuant to Section 4 shall not be deemed to be an amendment to this Warrant, provided, however, that the second paragraph of Section 2(e) may not be modified or amended or waived prior to obtaining the requisite stockholder approval.

 

  (m)

Invalidity. If, at any time, any term of this Warrant is or becomes illegal, invalid or unenforceable in any respect, or this Warrant is or becomes ineffective in any respect, under the laws of any jurisdiction, such illegality, invalidity, unenforceability, or ineffectiveness shall not affect:

 

  (i)

the legality, validity, or enforceability in that jurisdiction of any other term of this Warrant or the effectiveness in any other respect of this Warrant in that jurisdiction; or

 

  (ii)

the legality, validity or enforceability in other jurisdictions of that or any other term of this Warrant or the effectiveness of this Warrant under the laws of such other jurisdictions.

 

  (n)

Rights and Remedies are Cumulative. The rights and remedies provided by this Warrant are cumulative and do not exclude any rights and remedies provided by law.

 

  (o)

No Partnership. Nothing in this Warrant constitutes a partnership between the parties hereto or constitutes any party as agent of the other party for any purpose whatever and, no party has authority or power to bind the other or to contract in the name of or create liability against the other party in any way or for any purpose.

 

  (p)

Costs. The Company shall bear the costs and expenses of the Original Warrantholder in relation to the preparation, negotiation, execution, implementation, enforcement and termination of this Warrant or any ancillary documents, as well as any subsequent amendments, supplements, or waivers of or to this Warrant or any ancillary document, including the costs of any legal, accountancy, and other advisors and any exchange charges incurred, provided that the Company shall not be responsible for any costs or expenses of the Original Warrantholder in connection with a transfer or sale of this Warrant or Warrant Shares by the Warrantholder.

 

27


  (q)

Set-Off.

 

  (i)

No set-off by the Company. All payments to be made by the Company under this Warrant shall be calculated and be made without (and free and clear of any deduction for) set-off or counterclaim.

 

  (ii)

Set-off by Warrantholder. Original Warrantholder may set off any matured obligation due from the Company (to the extent beneficially owned by the Original Warrantholder) against any obligation (whether or not matured) owed by the Original Warrantholder to the Company (including the Strike Price owed with respect to any Warrants), regardless of the place of payment, booking branch, or currency of either obligation. If the obligations are in different currencies, the Original Warrantholder may convert either obligation at a market rate of exchange in its usual course of business for the purpose of the set-off. If either obligation is unliquidated or unascertained, the Original Warrantholder may set off in an amount estimated by it in good faith to be the amount of that obligation. All payments to be made by a Warrantholder other than the Original Warrantholder under this Warrant shall be calculated and be made without (and free and clear of any deduction for) set-off or counterclaim.

 

  (r)

Taxes, Duties, and Fees; Interest on Overdue Sums; Payments.

 

  (i)

Company to pay all taxes. The Company shall pay all taxes, duties, fees, and other impositions of whatsoever nature, including stamp duty and registration fees, arising out of the creation, preparation, execution, implementation, perfection, registration, enforcement, amendment (including supplements and waivers) or termination arising out of the Warrant Issuance Agreement, this Warrant or any additional Warrant issued pursuant to the Warrant Issuance Agreement, or any ancillary document, provided that the Company shall not be responsible for (i) any transfer tax payable in connection with the Warrantholder transferring or selling this Warrant or Warrant Shares, (ii) any capital gains and income taxes and any similar taxes and duties attributable to the Warrantholder, or (iii) any incremental tax due to the identity or tax characteristics of the Warrantholder as compared to the Original Warrantholder.

 

  (ii)

Company to gross up. The Company (or any nominee thereof paying any amount due under this Warrant) shall pay all amounts due under this Warrant gross without any withholding or deduction of any national or local impositions whatsoever, provided that if any such withholding or deduction is required by law or by an agreement with a governmental authority or otherwise, the Company (or such nominee) will gross up the payment to the Warrantholder so that after withholding or deduction, the net amount received by the Warrantholder is equivalent to the sum due; provided further that, the parties hereto shall cooperate and use their commercially reasonable efforts to deliver any documentation that may be required as will permit such amounts to be made without withholding or at a reduced rate of withholding.

 

28


  (iii)

Interest. If the Company fails to pay any amount payable by it under this Warrant on its due date, interest shall accrue on any such overdue amount from the due date to the date of actual payment at an annual rate equal to EURIBOR plus 2% (two hundred (200) basis points) and shall be payable in accordance with the demand of the Warrantholder. The Company hereby agrees in advance to have the unpaid interest due for a period of more than one year compounded and such unpaid interest will in turn produce interest at the interest rate set out in this Section 6(r)(iii).

 

  (iv)

Currency. If the overdue amount is in a currency other than Euros, the relevant interbank rate, or as determined by the Warrantholder, the relevant risk-free rate that is generally retained by the Warrantholder for transactions in Euros plus 2% (200 (two hundred) basis points) shall apply, calculated in accordance with the market practice for such rate.

 

  (v)

Fractional time. Any amount due under this Warrant and calculated in respect of a fraction of a year shall be determined based on a year of three hundred and sixty (360) days and the number of days elapsed.

 

  (s)

Third Party Rights. A person who is not a party hereto is not entitled to any rights under this Warrant.

 

  (t)

Mutual Drafting. This Warrant is the joint product of the Warrantholder and the Company and each provision hereof has been subject to the mutual consultation, negotiation and agreement of such parties and shall not be construed for or against any party hereto.

 

  (u)

Entire Agreement. This Warrant, the Warrant Issuance Agreement, and the other agreements and documents referred to herein constitute the entire agreement between the parties hereto in relation to the grant of this Warrant and the issuance of Warrant Shares, and supersedes any previous agreement, whether express or implied, on the same matter.

 

  (v)

Counterparts. This Warrant may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument. Each counterpart is an original, but all counterparts shall together constitute one and the same instrument.

[Signature Page Follows]

 

29


IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by its duly authorized officer as of the date first above indicated.

 

COMPANY

 

IO BIOTECH, INC.

By:  

 

Name:  
Title:  

[Signature Page to Common Stock Warrant – Tranche [___]]


ACKNOWLEDGED AND AGREED:

 

WARRANTHOLDER

 

THE EUROPEAN INVESTMENT BANK

By:  

 

Name:  
Title:  
By:  

 

Name:  
Title:  

[Signature Page to Common Stock Warrant – Tranche [___]]


EXHIBIT A

NOTICE OF EXERCISE

TO: IO BIOTECH, INC.

 

  (1)

The undersigned hereby elects to purchase ________ Warrant Shares of the Company pursuant to the terms of the attached Warrant (only if exercised in full), and tenders herewith payment of the exercise price in full, together with all applicable transfer taxes, if any.

 

  (2)

Payment shall take the form of (check applicable box):

[___] in lawful money of the United States; or

[___] if permitted, the cancellation of such number of Warrant Shares as is necessary, in accordance with the formula set forth in Section 2(c) (Cashless Exercise), to exercise this Warrant with respect to the maximum number of Warrant Shares purchasable pursuant to the cashless exercise procedure set forth in Section 2(c) (Cashless Exercise).

 

  (3)

Please issue said Warrant Shares in the name of the undersigned or in such other name as is specified below:

The Warrant Shares shall be delivered to the following DWAC Account Number:

 

  (4)

Accredited Investor. The undersigned is an “accredited investor” as defined in Regulation D promulgated under the Securities Act of 1933, as amended.

[SIGNATURE OF WARRANTHOLDER]

 

Name of Investing Entity:
                       
Signature of Authorized Signatory of Investing Entity:
                       
Name of Authorized Signatory:
                       
Title of Authorized Signatory:
                       
Date:
                       

 

[Exh A-1]


EXHIBIT B

ASSIGNMENT FORM

(To assign the foregoing Warrant, execute this form and supply required information. Do not use this form to purchase shares.)

FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned to:

 

Name:   

 

  
   (Please Print)   
Address:   

 

  
   (Please Print)   
Phone
Number:
 

 

Email
Address:
 

 

Dated: ___________________________________________

 

Transferee Warrantholder’s Signature:
By:  

 

Name:

Title:

 
Transferee Warrantholder’s Address:

 

 

[Exh B-1]


Name:   

 

  
   (Please Print)   
Address:   

 

  
   (Please Print)   

 

Phone
Number:
 

 

Email
Address:
 

 

Dated: ___________________________________________

 

Warrantholder’s Signature:
By:  

 

Name:

Title:

 
Warrantholder’s Address:

 

 

[Exh B-2]


EXHIBIT C

COMPANY CALL OPTION NOTICE

(THE “NOTICE”)

To: [ *** ]

FAO: [ *** ]

Common Stock Purchase Warrant issued on [___________], 202[_] (the “Warrant Agreement”)

We refer to the Warrant Agreement. Capitalized terms used in this Notice have the meanings ascribed to them in the Warrant Agreement.

We hereby provide this notice for the exercise of the Call Option with respect to the right to purchase the [ *** ] Warrant Shares purchasable under the Warrant.

Our good faith calculations of Fair Market Value and the Call Option Price applicable to such exercise of the Call Option are set out in the annex to this Notice, where the basis of calculation, assumptions and working papers are shown.

Pursuant to such calculations, the Call Option Price for such exercise of the Call Option is EUR [ *** ].

Please countersign this Notice to indicate your acceptance of this Notice, and confirm the account to which the Call Option Price should be remitted.

Signed by               

for and on behalf of

IO Biotech, Inc.

Full Name               

Address:

IO Biotech, Inc.

Ole Maaløes Vej 3

DKK-220 Copenhagen N

Denmark

Attention: Mai-Britt Zocca

 

[Exh C-1]


We hereby confirm our agreement to the Company Call Option Notice becoming final and binding. Please remit the Call Option Price to the account set forth below.

 

Warrantholder’s Signature:
By:  

 

Name:

Title:

 
Warrantholder’s Address:

 

 

Bank:    [ *** ]
Branch:    [ *** ]
Sort Code:    [ *** ]
Account Number:    [ *** ]
Account name:    [ *** ]
BIC:    [ *** ]
SWIFT:    [ *** ]
IBAN:    [ *** ]
Reference:    Call Option of IO Biotech, Inc. Warrants

 

[Exh C-2]


ANNEX A

SUPPORTING CALCULATIONS

[To be prepared at the time of a Notice]

 

[Exh C-3]


EXHIBIT D

EXPERT DETERMINATION

 

1.

IDENTITY AND SELECTION OF EXPERT

The Expert will be an independent and leading investment bank, an independent, leading global firm of accountants, or an independent, leading valuation firm, as jointly appointed by the Company and the Warrantholder which has not rendered material services to either the Company or the Warrantholder during the period commencing 3 (three) years prior to the date of the Warrant Issuance Agreement through to the date of exercise of the Call Option. Failing agreement as to such appointment after twenty (20) Business Days of the proposed referral to the Expert pursuant to Section 5(c)(ii) by the Warrantholder or the Company, the Warrantholder shall (in its sole discretion acting reasonably) appoint an Expert satisfying the above criteria ensuring that they are an independent valuation firm of recognized standing engaged in the business of valuing venture capital backed companies at all stages of development (from start-up to maturity).

 

2.

DUTIES OF EXPERT

The Expert will:

 

  (a)

determine (as appropriate) the Fair Market Value for any Warrant Shares on the basis set out in paragraph 3; and

 

  (b)

within one (1) month of the matter being referred to it, give written notice of its determination to the Company and the Warrantholder (the “Expert’s Certificate”), together with a written explanation setting out in reasonable detail the basis and methods used for the purposes of the calculations performed under the previous subparagraph.

 

3.

BASIS OF VALUATION

Fair Market Value shall be determined as follows:

 

  (a)

if Shares of Common Stock are listed on a Trading Market, Fair Market Value shall be equal to the 5-Day VWAP; or

 

  (b)

if Shares of Common Stock are not listed on a Trading Market, the fair market value of a Share of Common Stock as determined in accordance with the following valuation principles:

 

  1.

based on the full equity value of the Company and the terms of its outstanding securities without any discount for lack of liquidity, lack of control, restrictions on marketability, minority interests or lack of other rights of equity holders;

 

[Exh D-1]


  2.

by applying techniques that are appropriate in light of the nature, facts, and circumstances of such Shares;

 

  3.

using reasonable current market data and inputs combined with market participant assumptions; and

 

  4.

taking into account valuations retained in previous transaction or offers related to Instruments of the Company over the preceding twelve (12) month period;

 

  5.

based on the price that would be received for an asset or paid to transfer a liability in an Orderly Transaction, given market conditions at the measurement date, between market participants that are (i) independent of each other, (ii) knowledgeable of the market, (iii) able to transact and willing to transact, that is, they are motivated but not forced or otherwise compelled to do so. For the purposes hereof, any preferred rights shall be taken into consideration for the purposes of such valuation.

 

  6.

adding up any common and preferred distributions made to stockholders of the Company or holders of Instruments giving rise to any kind of distribution or profit entitlement since the date of issuance of the respective Warrants which have not been paid to the Warrantholder;

 

  7.

such valuation to be by guided by the International Private Equity and Venture Capital Valuation Guidelines as such are amended from time to time.

For the purposes of this paragraph 3 (Basis of Valuation), “Orderly Transaction” means a transaction that assumes exposure to the market for a period prior to the measurement date to allow for marketing activities that are usual and customary for transactions involving the respective assets or liabilities of a company or business like the Company at such time.

 

4.

TERMS OF APPOINTMENT OF EXPERT

The Company and the Warrantholder shall cooperate with each other and shall take all reasonable action as is necessary to ensure that the terms of appointment of the Expert will enable the Expert to give effect to and act in accordance with the provisions of this Exhibit D.

 

5.

EXPERT REFUSING OR CEASING TO ACT

If the Expert is unable for whatever reason to act, or does not deliver the decision within the time required by paragraph 2(b), the Company and the Warrantholder shall appoint a replacement expert in accordance with paragraph 1 of this Exhibit D.

 

[Exh D-2]


6.

LANGUAGE

All matters under this Exhibit D will be conducted, and the Expert’s decision will be written, in the English language.

 

7.

PARTIES TO PROVIDE INFORMATION AND MAKE SUBMISSIONS

The Company and the Warrantholder are entitled to make submissions to the Expert including oral submissions and shall provide (or procure that others provide) the Expert with such information, assistance, and documents necessary or as the Expert reasonably requires for the purpose of reaching a decision, subject to the Expert agreeing to give such confidentiality undertakings as the Company and the Warrantholder may reasonably require.

Any information disclosed to the Expert by the Company, or any person for or on behalf the Company shall also be disclosed simultaneously to the Warrantholder.

 

8.

EXPERT MAY DETERMINE PROCEDURES

To the extent not provided for by this Exhibit D, the Expert may, in its reasonable discretion, determine such other procedures consistent with best practices to assist with the conduct of the determination as such Expert considers just or appropriate, including (to the extent it considers necessary) instructing professional advisers to assist it in reaching its determination.

 

9.

CONDUCT OF PARTIES

The Company and the Warrantholder shall promptly take all such reasonable action which is necessary to give effect to the terms of this Exhibit D.

 

10.

EXPERT NOT ARBITRATOR

The Expert will act as an expert and not as an arbitrator. The Expert will determine any dispute arising in connection with the provisions of this Exhibit D, its jurisdiction to determine the matters and issues referred to it, or its terms of reference. The Expert’s written decision on the matters referred to it will be final and binding in the absence of manifest error or fraud.

 

11.

COSTS OF THE EXPERT

The Expert’s fees and any costs properly incurred by it in arriving at any determination (including any fees and costs of any advisers appointed by the Expert) will be paid to the Expert by the Company.

[The remainder of this page is intentionally left blank.]

 

[Exh D-3]

Exhibit 10.1

 

     

Contract number (FI No): 97869

 

Serapis No: 2024-0179

 

EIB Internal Classification Level –

Corporate Use

IO BIOTECH (IEU LS)

Finance Contract

between the

European Investment Bank

and

IO Biotech ApS

Luxembourg and Copenhagen 19 December 2024


WHEREAS:

     6  

ARTICLE 1

     7  

1.1

  

INTERPRETATION

     7  

1.2

  

CALCULATIONS OF BASKETS, ETC.

     8  

1.3

  

DEFINITIONS

     8  

ARTICLE 2

     18  

2.1

  

AMOUNT OF CREDIT

     18  

2.2

  

DISBURSEMENT PROCEDURE

     18  

2.2.1

  

TRANCHES

     18  

2.2.2

  

DISBURSEMENT OFFER

     18  

2.2.3

  

DISBURSEMENT ACCEPTANCE

     19  

2.3

  

DISBURSEMENT ACCOUNT

     19  

2.4

  

CURRENCY OF DISBURSEMENT

     19  

2.5

  

CONDITIONS OF DISBURSEMENT

     19  

2.5.1

  

INITIAL DOCUMENTARY CONDITIONS PRECEDENT

     19  

2.5.2

  

ALL TRANCHES - DOCUMENTARY CONDITIONS PRECEDENT

     20  

2.5.3

  

ALL TRANCHES – OTHER CONDITIONS

     20  

2.5.4

  

TRANCHE A – ADDITIONAL CONDITIONS PRECEDENT

     20  

2.5.5

  

TRANCHE B – ADDITIONAL CONDITIONS PRECEDENT

     20  

2.5.6

  

TRANCHE C – ADDITIONAL CONDITIONS PRECEDENT

     21  

2.6

  

CANCELLATION

     21  

2.7

  

FEE FOR CANCELLATION OF AN ACCEPTED TRANCHE

     22  

2.8

  

CANCELLATION AFTER EXPIRY OF THE CREDIT

     22  

2.9

  

DROP DEAD FEES

     22  

2.10

  

SUMS DUE UNDER ARTICLE 2

     22  

ARTICLE 3

     23  

3.1

  

AMOUNT OF LOAN

     23  

3.2

  

CURRENCY OF REPAYMENT, INTEREST AND OTHER CHARGES

     23  

ARTICLE 4

     23  

4.1

  

PAYMENT IN KIND (PIK) INTEREST

     23  

4.2

  

WARRANTS

     23  

4.3

  

INTEREST ON OVERDUE SUMS

     23  

ARTICLE 5

     24  

5.1

  

SINGLE INSTALMENT

     24  

5.2

  

VOLUNTARY PREPAYMENT

     24  

5.2.1

  

PREPAYMENT OPTION

     24  

5.2.2

  

PREPAYMENT FEE

     24  

5.2.3

  

PREPAYMENT MECHANICS

     24  

5.3

  

COMPULSORY PREPAYMENT AND CANCELLATION

     24  

5.3.1

  

INVESTMENT COST REDUCTION EVENT

     24  

5.3.2

  

CHANGE EVENTS

     25  

5.3.3

  

ILLEGALITY EVENT

     25  

5.3.4

  

VOLUNTARY NON-EIB PREPAYMENT EVENT

     25  

5.3.5

  

DISPOSALS

     25  

5.3.6

  

PREPAYMENT FEE

     26  

 

2


5.3.7

  

PREPAYMENT MECHANICS

     26  

5.4

  

GENERAL

     26  

ARTICLE 6

     26  

6.1

  

DAY COUNT CONVENTION

     26  

6.2

  

TIME AND PLACE OF PAYMENT

     26  

6.3

  

NO SET-OFF BY THE BORROWER

     27  

6.4

  

DISRUPTION TO PAYMENT SYSTEMS

     27  

6.5

  

APPLICATION OF SUMS RECEIVED

     27  

6.5.1

  

GENERAL

     27  

6.5.2

  

PARTIAL PAYMENTS

     27  

6.5.3

  

ALLOCATION OF SUMS RELATED TO TRANCHES

     27  

ARTICLE 7

     27  

7.1

  

REPRESENTATIONS AND WARRANTIES

     27  

7.2

  

UNDERTAKINGS

     28  

ARTICLE 8

     28  

8.1

  

TAXES, DUTIES AND FEES

     28  

8.2

  

OTHER CHARGES

     28  

8.3

  

INCREASED COSTS, INDEMNITY AND SET-OFF

     28  

ARTICLE 9

     29  

9.1

  

RIGHT TO DEMAND REPAYMENT

     29  

9.2

  

OTHER RIGHTS AT LAW

     30  

9.3

  

PREPAYMENT FEE

     30  

9.4

  

NON-WAIVER

     30  

9.5

  

AUTOMATIC ACCELERATION

     30  

ARTICLE 10

     31  

10.1

  

GOVERNING LAW

     31  

10.2

  

JURISDICTION

     31  

10.3

  

PLACE OF PERFORMANCE

     31  

10.4

  

EVIDENCE OF SUMS DUE

     31  

10.5

  

ENTIRE AGREEMENT

     31  

10.6

  

INVALIDITY

     31  

10.7

  

AMENDMENTS

     31  

10.8

  

COUNTERPARTS

     31  

10.9

  

ASSIGNMENT AND TRANSFER BY THE BANK

     32  

10.10

  

NO MNPI OR PROHIBITED DISCLOSURES

     32  

ARTICLE 11

     34  

11.1

  

NOTICES

     34  

11.1.1

  

FORM OF NOTICE

     34  

11.1.2

  

ADDRESSES

     34  

11.1.3

  

DEMAND AFTER NOTICE TO REMEDY

     35  

11.2

  

US PATRIOT ACT

     35  

 

3


11.3

  

ENGLISH LANGUAGE

     35  

SCHEDULE A

     37  

INVESTMENT SPECIFICATION AND REPORTING

     37  

INVESTMENT INFORMATION TO BE SENT TO THE BANK AND METHOD OF TRANSMISSION

     38  

SCHEDULE B

     41  

DEFINITION OF EURIBOR

     41  

SCHEDULE C

     43  

FORM OF DISBURSEMENT OFFER/ACCEPTANCE

     43  

SCHEDULE D

     45  

FORM OF DRAWDOWN CERTIFICATE

     45  

SCHEDULE E

     46  

FORM OF COMPLIANCE CERTIFICATE

     46  

SCHEDULE F

     47  

INITIAL DOCUMENTARY CONDITIONS PRECEDENT

     47  

SCHEDULE G

     49  

REPRESENTATIONS AND WARRANTIES

     49  

SCHEDULE H

     52  

GENERAL UNDERTAKINGS

     52  

SCHEDULE I

     63  

INFORMATION AND VISITS

     63  

SCHEDULE J

     67  

POSITIVE PHASE II STUDY

     67  

 

4


THIS CONTRACT IS MADE BETWEEN:

 

the European Investment Bank having its seat at 100 blvd Konrad Adenauer, Luxembourg, L-2950 Luxembourg, represented by Maria-Teresa Massaad and Yu Zhang

   (the “Bank”)

of the first part, and

  

IO Biotech ApS (company number 36474483) a private limited liability company incorporated in Denmark, having its registered office at C/O COBIS Ole Maaløes Vej 3, 2200 København N represented by Mai-Britt Zocca

   (the “Borrower”)

of the second part.

The Bank and the Borrower together are referred to as the “Parties” and any of them is a “Party”.

 

5


WHEREAS:

 

  (A)

The Borrower has stated that it is undertaking a research and development project relating to an innovative immunotherapeutic cancer vaccine to treat melanoma as more particularly described in the technical description (the “Technical Description”) set out in Schedule A (Investment Specification and Reporting) (the “Investment”). The total cost of the Investment, as estimated by the Bank, is EUR 100,000,000.00 (one hundred million euro).

 

  (B)

The Bank, considering that the financing of the Investment falls within the scope of its functions, agreed to provide the Borrower with a credit in an amount of EUR 37,500,000.00 (thirty-seven million five hundred thousand euro) under this Finance Contract (the “Contract”) to finance the Investment; provided that the amount of the loan hereunder and any loan provided by another implementing partner under the InvestEU Fund (as defined below) shall not, in any case, together exceed 50% (fifty per cent.) of the total cost of the Investment.

 

  (C)

The Borrower is a subsidiary of IO Biotech, Inc. (file no. 5924808), a company incorporated in Delaware, having its registered office at 430 E 29th St., Suite 940, New York, NY 10016 and publicly listed on the NASDAQ stock exchange (NASDAQ: IOBT) (the “Parent”).

 

  (D)

The Parent has further agreed to grant the Bank certain rights to purchase shares of the common stock of Parent pursuant to the Warrant Agreements (as defined below) in the Parent as remuneration for the Loan (as defined below) and in accordance with the terms of a Warrant Issuance Agreement (as defined below) and to take all actions available to it and its corporate bodies (including passing all necessary corporate resolutions) to enable the Parent to grant such rights and to execute such Warrant Agreements as set out in the Warrant Issuance Agreement.

 

  (E)

On or around the date of this Contract, the Parties have entered into a side letter to reflect their non-binding commercial understanding that, subject to the Bank’s credit approval and to agreement on terms, the Bank will consider a subsequent request by the Borrower to provide additional funding to the Investment or other project investment costs acceptable to the Bank in an amount to be agreed but not exceeding EUR 20,000,000 (twenty million euro).

 

  (F)

This operation benefits from support from the European Union under the InvestEU Fund.

 

  (G)

The statute of the Bank provides that the Bank shall ensure that its funds are used as rationally as possible in the interests of the European Union; and, accordingly, the terms and conditions of the Bank’s loan operations must be consistent with relevant policies of the European Union.

 

  (H)

The Bank considers that access to information plays an essential role in the reduction of environmental and social risks, including human rights violations, linked to the projects it finances and has therefore established its transparency policy, the purpose of which is to enhance the accountability of the Bank’s group towards its stakeholders and the citizens of the European Union in general.

 

  (I)

The processing of personal data shall be carried out by the Bank in accordance with applicable EU Law on the protection of individuals with regard to the processing of personal data by the European Union institutions and bodies and on the free movement of such data. For the purposes of the GDPR (as defined below) and Regulation (EU) 2018/1725, the Parties acknowledge their mutual understanding that each Party will act as an independent controller, and not a processor on behalf of or joint controller with the other Party, when processing personal data in connection with this Contract.

 

6


  (J)

The Bank supports the implementation of international and European Union standards in the field of anti-money laundering and countering the financing of terrorism and promotes tax good governance standards. It has established policies and procedures to avoid the risk of misuse of its funds for purposes which are illegal or abusive in relation to applicable laws. The Bank’s group statement on tax fraud, tax evasion, tax avoidance, aggressive tax planning, money laundering and financing of terrorism is available on the Bank’s website and offers further guidance to the Bank’s contracting counterparties.

It is hereby agreed as follows:

ARTICLE 1

Interpretation and definitions

 

1.1

Interpretation

In this Contract:

 

  (a)

references to “Articles”, “Recitals”, “Schedules” and “(Sub-)Paragraphs” are, save if explicitly stipulated otherwise, references respectively to articles of, and recitals, schedules and (sub-)paragraphs of schedules to, this Contract. All Recitals and Schedules form part of this Contract;

 

  (b)

references to “law” or “laws” mean:

 

  (i)

any applicable law and any applicable treaty, constitution, statute, legislation, decree, normative act, rule, regulation, judgement, order, writ, injunction, determination, award or other legislative or administrative measure or judicial or arbitral decision in any jurisdiction which is binding or applicable case law; and

 

  (ii)

EU Law;

 

  (c)

references to “applicable law”, “applicable laws” or “applicable jurisdiction” mean:

 

  (i)

a law or jurisdiction applicable to the Borrower and/or any other Obligor (as the context requires), its rights and/or obligations (in each case arising out of or in connection with the Finance Documents), its capacity and/or assets and/or the Investment; and/or, as applicable;

 

  (ii)

a law or jurisdiction (including in each case the Bank’s Statute) applicable to the Bank, its rights, obligations, capacity and/or assets;

 

  (d)

references to a provision of law or a treaty are references to that provision as amended, supplemented, restated or re-enacted;

 

  (e)

references to any Finance Document or other agreement or instrument are references to that Finance Document or other agreement or instrument as amended, novated, supplemented, extended or restated;

 

  (f)

words and expressions in plural shall include singular and vice versa;

 

  (g)

a Default (other than an Event of Default) is “continuing” if it has not been remedied or waived and an Event of Default is “continuing” if it has not been waived;

 

  (h)

terms defined in the GDPR (as defined below), including the terms “controller”, “data subject”, “personal data”, “processing” and “processor”, have the same meanings when used in Recital (I) to, or Paragraph 25 (Data Protection) of Schedule H (General Undertakings) of, this Contract;

 

  (i)

references to “month” mean a period starting on one day in a calendar month and ending on the numerically corresponding day in the next calendar month, except that and subject to the definition of Payment Date, Article 6.1 (Day count convention) and Schedule B (Definition of EURIBOR) and unless provided otherwise in this Contract:

 

  (i)

if the numerically corresponding day is not a Business Day, that period shall end on the next Business Day in that calendar month in which that period is to end if there is one, or if there is not, on the immediately preceding Business Day; and

 

7


  (ii)

if there is no numerically corresponding day in the calendar month in which that period is to end, that period shall end on the last Business Day in that calendar month; and

 

  (j)

a reference in this Contract to a page or screen of an information service displaying a rate shall include:

 

  (i)

any replacement page of that information service which displays that rate; and

 

  (ii)

the appropriate page of such other information service which displays that rate from time to time in place of that information service,

and, if such page or service ceases to be available, shall include any other page or service displaying that rate specified by the Bank.

 

1.2

Calculations of baskets, etc.

Any amounts incurred or transaction undertaken on the basis of any basket, test or permission in this Contract where an element is determined by reference to Total Assets (a “Relevant Basket”) shall (provided that such amounts are, at the time of incurrence, duly and properly incurred in accordance with the relevant basket, test or permission) be treated as having been duly and properly incurred without the occurrence of a Default or an Event of Default even in the event that such Relevant Basket subsequently decreases by virtue of the operation of that calculation.

 

1.3

Definitions

In this Contract:

4th and 5th AML Directives” means Directive 2015/849 of the European Parliament and of the Council of 20 May 2015 on the prevention of the use of the financial system for the purposes of money laundering or terrorist financing (the “4th AML Directive”), as amended by Directive 2018/843 of the European Parliament and of the Council of 30 May 2018.

Accepted Tranche” means a Tranche in respect of which a Disbursement Offer has been duly accepted by the Borrower in accordance with its terms on or before the Disbursement Acceptance Deadline

acting in concert” means acting together pursuant to an agreement or understanding (whether formal or informal).

Affiliate” means in respect of any entity, another entity that directly or indirectly is in Control of, is Controlled by, or is under common Control with that entity.

AML Criminal Law Directive” means Directive (EU) 2018/1673 of the European Parliament and of the Council of 23 October 2018 on combating money laundering by criminal law.

AML Directives” means the 4th and 5th AML Directives and the AML Criminal Law Directive.

Authorisation” means an authorisation, permit, consent, approval, resolution, licence, exemption, filing, notarisation or registration.

Authorised Signatory” means a person authorised to sign individually or jointly (as the case may be) Disbursement Acceptances on behalf of the Borrower and named in the most recent List of Authorised Signatories and Accounts received by the Bank prior to the receipt of the relevant Disbursement Acceptance.

Automatic Acceleration Event” has the meaning given to that term in Article 9.5 (Automatic Acceleration).

Business Day” means a day (other than a Saturday or Sunday) on which the Bank and commercial banks are open for general business in Copenhagen and Luxembourg.

Cancellation Fee” means, in relation to the cancellation of an Accepted Tranche by the Borrower under sub-paragraph (a) of Article 2.7 (Fee for cancellation of an Accepted Tranche), or in relation to an amount cancelled by the Bank under sub-paragraphs (b) or (c) of Article 2.7 (Fee for cancellation of an Accepted Tranche), a fee of 2% (two hundred basis points) of the cancelled amount.

 

8


Change in the Beneficial Ownership” means a change in the ultimate ownership or control of an entity according to the definition of “beneficial owner” set out in article 3(6) of the 4th AML Directive it being specified that, for the purposes of this Contract the threshold of beneficial ownership is set at 10% (ten per cent.).

Change-of-Control Event” means any person or group of persons acting in concert gains Control of the Parent or of any entity directly or ultimately Controlling the Parent.

Change-of-Law Event” means the enactment, promulgation, execution or ratification of or any change in or amendment to any law, rule or regulation (or in the application or official interpretation of any law, rule or regulation) that occurs after the date of this Contract and which, in the reasonable opinion of the Bank, would materially impair an Obligor’s ability to perform its obligations under the Finance Documents.

Code” means the US Internal Revenue Code of 1986.

Compliance Certificate” means a certificate substantially in the form set out in Schedule E (Form of Compliance Certificate).

Contract” has the meaning given to it in Recital (B).

Contract Number” means the Bank generated number identifying this Contract and indicated on the cover page of this Contract after the letters “FI N°”.

Control” means the power to direct the management and policies of an entity, whether through the ownership of voting capital, by contract or otherwise and, for the avoidance of doubt, owning more than 50% (fifty per cent.) of the shares of an entity would constitute Control, and “Controlling” has corresponding meaning.

Credit” has the meaning given to it in Article 2.1 (Amount of Credit).

Cross-border Project” means a financing operation which:

 

  (a)

involves entities located or established in one or more Member State(s); and

 

  (b)

extends to one or more third countries, including acceding States, candidate countries and potential candidates, countries falling within the scope of the European Neighbourhood Policy, the European Economic Area or the European Free Trade Area, to an overseas country or territory linked to a Member State as set out in Annex II to the TFEU (OCT).

Declaration of Honour” means the “Declaration of Honour under InvestEU operations” signed by the Borrower on 6 December 2024.

Default” means an Event of Default or any event or circumstance specified in Article 9 (Events of Default) which would (with the expiry of a grace period, the giving of notice, the making of any determination under this Contract or any combination of any of the foregoing) be an Event of Default.

Disbursement Acceptance” means a copy of the Disbursement Offer duly countersigned by the Borrower in accordance with the List of Authorised Signatories and Accounts.

Disbursement Acceptance Deadline” means the date and time of expiry of a Disbursement Offer as specified therein.

Disbursement Account” means, in respect of each Tranche, the bank account to which disbursements may be made under this Contract, as set out in the most recent List of Authorised Signatories and Accounts.

Disbursement Date” means the date on which disbursement of a Tranche is made by the Bank.

Disbursement Offer” means a letter substantially in the form set out in Schedule C (Form of Disbursement Offer/Acceptance).

Dispute” has the meaning given to it in Article 10.2 (Jurisdiction).

 

9


Disruption Event” means either or both of:

 

  (a)

a material disruption to those payment or communications systems or to those financial markets which are, in each case, required to operate in order for payments to be made in connection with this Contract; or

 

  (b)

the occurrence of any other event which results in a disruption (of a technical or systems-related nature) to the treasury or payments operations of either the Bank or the Borrower, preventing that Party from:

 

  (i)

performing its payment obligations under this Contract; or

 

  (ii)

communicating with the other Party in accordance with the terms of this Contract,

and which disruption (in either such case as per (a) or (b) above) is not caused by, and is beyond the control of, the Party whose operations are disrupted.

Drop Dead Fees” has the meaning given to such term in Article 2.9 (Drop Dead Fees).

EBITDA” means, in respect of any Relevant Period, the consolidated operating profit of the Group before taxation (excluding the results from discontinued operations):

 

  (a)

before deducting any interest, commission, fees, discounts, prepayment fees, premiums or charges and other finance payments whether paid, payable or capitalised by any Group Company (calculated on a consolidated basis) in respect of that Relevant Period;

 

  (b)

not including any accrued interest owing to any Group Company;

 

  (c)

after adding back any amount attributable to the amortisation or depreciation of assets of members of the Group;

 

  (d)

before taking into account any Exceptional Items;

 

  (e)

after deducting the amount of any profit (or adding back the amount of any loss) of any Group Company which is attributable to minority interests;

 

  (f)

plus or minus the Group’s share of the profits or losses (after finance costs and tax) of entities which are not Group Companies;

 

  (g)

before taking into account any unrealised gains or losses on any financial instrument (other than any derivative instrument which is accounted for on a hedge accounting basis); and

 

  (h)

before taking into account any gain arising from an upward revaluation of any other asset,

in each case, to the extent added, deducted or taken into account, as the case may be, for the purposes of determining operating profits of the Group before taxation.

Eligible Territory” means the territory of:

 

  (a)

a Member State or an overseas country or territory linked to a Member State as set out in Annex II to the TFEU (OCT);

 

  (b)

Norway and Iceland;

 

  (c)

a third country to which the Contract extends in case of Cross-border Projects; or

 

  (d)

another third country, where necessary for the financing of a project in a country or territory referred to in points (a), (b) or (c) above.

Environment” means the following:

 

  (a)

fauna and flora, living organisms including the ecological systems;

 

  (b)

land, soil, water (including marine and coastal waters), air, climate and the landscape (natural or man-made structures, whether above or below ground);

 

  (c)

cultural heritage (natural, tangible and intangible);

 

  (d)

the built environment; and

 

10


  (e)

human health and wellbeing.

Environmental and Social Approval” means any Authorisation required by Environmental and Social Law.

Environmental or Social Claim” means any claim, proceeding, formal notice or investigation by any person in respect of any Environmental and Social Law.

Environmental and Social Law” means:

 

  (a)

EU Law, including principles and standards;

 

  (b)

Danish national laws; and

 

  (c)

applicable international treaties,

in each case of which a principal objective is the preservation, protection or improvement of the Environment and/or the protection or improvement of Social Matters.

EU Law” means the acquis communautaire of the European Union as expressed through the Treaties of the European Union, the regulations, directives, delegated acts, implementing acts, principles, decisions and the case law of the Court of Justice of the European Union.

EUR” or “euro” means the lawful currency of the Member States of the European Union which adopt or have adopted it as their currency in accordance with the relevant provisions of the Treaty on European Union and the Treaty on the Functioning of the European Union.

EURIBOR” has the meaning given to it in Schedule B (Definition of EURIBOR).

Event of Default” means any of the circumstances, events or occurrences specified in Article 9 (Events of Default).

Exceptional Items” means any material items of an unusual or non-recurring nature which represent gains or losses including those arising on:

 

  (a)

the restructuring of the activities of an entity and reversals of any provisions for the cost of restructuring;

 

  (b)

disposals, revaluations, write downs or impairment of non-current assets or any reversal of any write down or impairment;

 

  (c)

disposals of assets associated with discontinued operations; and

 

  (d)

any other examples of “exceptional items” (as such term has the meaning attributed to it in IFRS).

Exclusion Policy” means the European Investment Bank Exclusion Policy as published on the Bank’s website.

FATCA” means:

 

  (a)

Sections 1471 to 1474 of the Code or any associated regulations;

 

  (b)

any treaty, law, regulation or other official guidance enacted in any other jurisdiction, or relating to an intergovernmental agreement between the United States and any other jurisdiction, which (in either case) facilitates the implementation of any law or regulation referred to in paragraph (a) above; or

 

  (c)

any agreement pursuant to the implementation of any treaty, law or regulation referred to in paragraphs (a) or (b) above with the US Internal Revenue Service, the US government or any governmental or taxation authority in any other jurisdiction.

FATCA Deduction” means a deduction or withholding from a payment under a Finance Document required by FATCA.

FATCA Exempt Party” means a Party that is entitled to receive payments free from any FATCA Deduction.

FATCA FFI” means a foreign financial institution as defined in section 1471(d)(4) of the Code which, if the Bank is not a FATCA Exempt Party, could be required to make a FATCA Deduction.

 

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Fee Letter” means the letter from the Bank to the Borrower dated 19 July 2024 (OPS/EGPF/-2-DTLS/2024-0179/ADL/ms).

Final Availability Date” means:

 

  (a)

for Tranche A, the day falling 6 (six) months after the date of this Contract;

 

  (b)

for Tranche B, the day falling 24 (twenty-four) months after the date of this Contract; and

 

  (c)

for Tranche C, the day falling 36 (thirty-six) months after the date of this Contract.

Finance Documents” means:

 

  (a)

this Contract;

 

  (b)

any Guarantee Agreement;

 

  (c)

the Warrant Issuance Agreement;

 

  (d)

any Warrant Agreement;

 

  (e)

the Registration Rights Agreement;

 

  (f)

the Fee Letter; and

 

  (g)

any other document designated a “Finance Document” by the Borrower and the Bank.

Finance Lease” means any lease or hire purchase contract which would, in accordance with IFRS in force prior to 1 January 2019, be treated as a finance or capital lease.

Fixed Assets” means a long-term tangible property or equipment used by the Group to operate its business as shown in the Parent’s latest consolidated financial statements, as at the end of any Relevant Period.

GAAP” means generally accepted accounting principles in Denmark, including IFRS.

GDPR” means General Data Protection Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC.

Group” means the Group Companies, taken together as a whole.

Group Company” means the Parent and its Subsidiaries.

Guarantee Agreement” means the Parent Guarantee Agreement, a Guarantee Agreement duly executed by IOB US and any other guarantee and indemnity agreement in form and substance satisfactory to the Bank to be entered into by a Guarantor as guarantor and the Bank as beneficiary.

Guarantor” means:

 

  (a)

the Parent;

 

  (b)

IOB US; and

 

  (c)

each Material Subsidiary (and any other Group Company, as the case may be) which enters into a Guarantee Agreement, including in accordance with sub-paragraph (b) of Paragraph 16 (Guarantees) of Schedule H (General Undertakings), allowing the Borrower to fulfil its undertaking under Paragraph 29 (Obligors’ revenues, assets and EBITDA threshold) of Schedule H (General Undertakings).

IFRS” means international accounting standards within the meaning of IAS Regulation 1606/2002 to the extent applicable to the relevant financial statements.

Illegal Activities” means any of the following illegal activities or activities carried out for illegal purposes according to applicable laws in any of the following areas: (i) fraud, corruption, coercion, collusion or obstruction, (ii) money laundering, financing of terrorism or tax crimes each as defined in the AML Directives, and (iii) other illegal activity against the financial interests of the European Union as defined in the PIF Directive.

Illegality Event” has the meaning given to it in Article 5.3.3 (Illegality Event).

 

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Indebtedness” means any:

 

  (a)

obligations for borrowed money;

 

  (b)

indebtedness under any acceptance credit;

 

  (c)

indebtedness under any bond, debenture, note or similar instrument;

 

  (d)

instrument under any bill of exchange;

 

  (e)

indebtedness in respect of any interest rate or currency swap or forward currency sale or purchase or other form of interest or currency hedging transaction (including without limit caps, collars and floors);

 

  (f)

indebtedness under any Finance Lease;

 

  (g)

indebtedness (actual or contingent) under any guarantee, bond security, indemnity or other agreement;

 

  (h)

indebtedness (actual or contingent) under any instrument entered into for the purpose of raising finance;

 

  (i)

indebtedness in respect of a liability to reimburse a purchaser of any receivables sold or discounted in the event that any amount of those receivables is not paid;

 

  (j)

indebtedness arising under a securitisation; or

 

  (k)

other transaction which has the commercial effect of borrowing.

Intellectual Property Rights” means intellectual property rights of every designation (including, without limitation, patents, utility patents, copyrights, design rights, trademarks, service marks and know how) whether capable of registration or not.

Intercompany Loan” means a loan between 2 (two) Group Companies.

InvestEU Fund” means the InvestEU Fund as established, inter alia, under the InvestEU Regulation.

InvestEU Fund MSS Declaration” means the “InvestEU Minimum Social Safeguards (MSS) Declaration signed by the Borrower on 6 December 2024.

InvestEU Regulation” means the regulation (EU) of the European Parliament and of the Council of 24 March 2021 establishing the InvestEU Programme and amending regulation (EU) 2015/1017 (OJ L 107, 26.3.2021, p. 30).

Investment” has the meaning given to that term in Recital (A).

Investment Cost Reduction Event” has the meaning given to it in Article 5.3.1 (Investment Cost Reduction Event)

IOB US” means IO Bio US, Inc. (file no. 5956026), a company incorporated in Delaware, having its registered office at 5640 Fishers Lane, Suite C, Rockville, MD 20852.

Lead Organisation” means the European Union, the United Nations and international standard setting organisations including the International Monetary Fund, the Financial Stability Board, the Financial Action Task Force, the Organisation for Economic Cooperation and Development and the Global Forum on Transparency and Exchange of Information for Tax Purposes and any successor organisations.

Legal Reservations” means:

 

  (a)

the principle that equitable remedies may be granted or refused at the discretion of a court and the limitation of enforcement by laws relating to insolvency, reorganization and other laws generally affecting the rights of creditors;

 

  (b)

the time barring of claims under statutes of limitation, and defences of set-off or counterclaim under mandatory law of any relevant jurisdiction;

 

  (c)

similar principles, rights and defences under the mandatory laws of any relevant jurisdiction; and

 

13


  (d)

any other matters which are set out as qualifications or reservations as to matters of law of general application in any legal opinion delivered to the Bank under or in connection with the Finance Documents.

List of Authorised Signatories and Accounts” means a list, in form and substance satisfactory to the Bank, setting out:

 

  (a)

the Authorised Signatories, accompanied by evidence of signing authority of the persons named on the list and specifying if they have individual or joint signing authority;

 

  (b)

the specimen signatures of such persons;

 

  (c)

the bank account(s) to which disbursements may be made under this Contract (specified by IBAN code if the country is included in the IBAN Registry published by SWIFT, or in the appropriate account format in line with the local banking practice), BIC/SWIFT code of the bank and the name of the bank account(s) beneficiary, together with evidence that such account(s) have been opened in the name of the beneficiary; and

 

  (d)

the bank account(s) from which payments under this Contract will be made by the Borrower (specified by IBAN code if the country is included in the IBAN Registry published by SWIFT, or in the appropriate account format in line with the local banking practice), BIC/SWIFT code of the bank and the name of the bank account(s) beneficiary, together with evidence that such account(s) have been opened in the name of the beneficiary.

Loan” means the aggregate of the amounts disbursed from time to time by the Bank under this Contract.

Loan Outstanding” means the aggregate of the amounts disbursed from time to time by the Bank under this Contract that remains outstanding.

Material Adverse Change” means any event or change of condition, which, in the reasonable opinion of the Bank, has a material adverse effect on:

 

  (a)

the ability of any Obligor to perform its payment or other material obligations under the Finance Documents;

 

  (b)

the business, operations or property of any Obligor (other than IOB US provided that it is not a Material Subsidiary) or the Group as a whole; or

 

  (c)

subject to the Legal Reservations, the legality, validity or enforceability of, or the effectiveness or ranking of, any Security granted to the Bank, or the rights or remedies of the Bank under the Finance Documents.

Material Press Release” means a press release that causes the price per share of common stock of the Parent to increase or decrease by 5% (five per cent.) or more:

 

  (a)

if the press release is issued prior to the market opening on a Trading Day, during the course of such Trading Day; or

 

  (b)

if the press release is issued during market opening hours on a Trading Day or after market close on a Trading Day, during the course of the subsequent Trading Day.

Material Subsidiary” means any Subsidiary from time to time, whose gross revenues, total assets or EBITDA represents more than 10% of:

 

  (a)

the consolidated gross revenues of the Group;

 

  (b)

the Total Assets; or

 

  (c)

the consolidated EBITDA of the Group,

as calculated based on the then latest consolidated audited accounts of the Group.

Maturity Date” means, for each Tranche, the sole repayment date, which shall be a Payment Date, of that Tranche as specified in the relevant Disbursement Offer, being 6 years from the Disbursement Date of the relevant Tranche.

 

14


MNPI” has the meaning given to it in paragraph (c) of Article 10.10 (No MNPI or prohibited disclosures).

Non-EIB Financing” means any loan (save for the Loan and any other direct loans from the Bank to the Borrower or a Guarantor), credit bond or other form of Indebtedness or any obligation for the payment or repayment of money originally granted to the Borrower or a Guarantor) in each case provided that any debt with an original maturity date that falls prior to the Maturity Date applicable to any disbursed Tranche shall not constitute Non-EIB Financing.

Obligor” means the Borrower and each Guarantor.

Parent” has the meaning given to that term in Recital (C).

Parent Guarantee Agreement” means the Guarantee Agreement to be provided by the Parent to the Bank.

Payment Account” means the bank account from which payments under this Contract will be made by the Borrower, as set out in the most recent List of Authorised Signatories and Accounts.

Payment Date” means the annual dates specified in the Disbursement Offer until and including the Maturity Date, save that, in case any such date is not a Relevant Business Day, it means the following Relevant Business Day, without adjustment to the interest under Article 4.1 (Payment in Kind (PIK) Interest) except for the final interest capitalisation only, when it shall mean the preceding Relevant Business Day, with adjustment to the interest under Article 4.1 (Payment in Kind (PIK) Interest).

Permitted Guarantees” means each and every guarantee permitted in accordance with Paragraph 16 (Guarantees) of Schedule H (General Undertakings).

Permitted Hedging” has the meaning given to such term in Paragraph 17 (Hedging) of Schedule H (General Undertakings).

Permitted Indebtedness” means Indebtedness of the Borrower and/or any Group Company which is permitted in accordance with Paragraph 15 (Indebtedness) of Schedule H (General Undertakings).

Permitted Security” means Security of the Borrower and/or any Group Company which is permitted in accordance with sub-paragraph (c) of Paragraph 23 (Negative pledge) of Schedule H (General Undertakings).

PIF Directive” means Directive (EU) 2017/1371 of the European Parliament and of the Council of 5 July 2017 on the fight against fraud to the European Union’s financial interests by means of criminal law.

PIK Interest Rate” means 8% (eight hundred basis points) per annum.

Prepayment Amount” means the amount of a Tranche to be prepaid by the Borrower in accordance with Articles 5.2 (Voluntary prepayment), 5.3 (Compulsory prepayment and cancellation) or 9.1 (Right to demand repayment).

Prepayment Date” means the date as requested by the Borrower and agreed by the Bank or indicated by the Bank, as applicable, on which the Borrower shall effect prepayment of a Prepayment Amount.

Prepayment Event” means any of the events described in Article 5.3 (Compulsory Prepayment).

Prepayment Fee” means, in relation to a Prepayment Amount in respect of a Tranche, a fee as follows:

 

  (a)

a fee of 5% (five hundred basis points) of the Prepayment Amount if the Prepayment Date is after the relevant Disbursement Date but before or on the first anniversary of such Disbursement Date;

 

  (b)

a fee of 3% (three hundred basis points) of the Prepayment Amount if the Prepayment Date is after the first anniversary of the relevant Disbursement Date but before or on the second anniversary of such Disbursement Date;

 

15


  (c)

a fee of 2% (two hundred basis points) of the Prepayment Amount if the Prepayment Date is after the second anniversary of the relevant Disbursement Date but before or on the third anniversary of such Disbursement Date; or

 

  (d)

a fee of 1% (one hundred basis points) of the Prepayment Amount if the Prepayment Date is after the third anniversary of the relevant Disbursement Date but before or on the fourth anniversary of such Disbursement Date,

with such fee being payable on the applicable Prepayment Date. For the avoidance of doubt, no Prepayment Fee shall be payable if the Prepayment Date is after the fourth anniversary of the relevant Disbursement Date but before or on the Maturity Date.

Prepayment Notice” means a written notice from the Bank to the Borrower in accordance with Article 5.2.3 (Prepayment mechanics).

Prepayment Request” means a written request from the Borrower to the Bank to prepay all or part of the Loan Outstanding, in accordance with Article 5.2.1 (Prepayment option).

Registration Rights Agreement” means the registration rights agreement contemplating the registration for resale of any shares of common stock of the Parent purchased by the Bank pursuant to the Warrant Agreements, to be entered into by and between the Parent and the Bank, in form and substance satisfactory to the Bank.

Relevant Business Day” means a day on which real time gross settlement system operated by the Eurosystem (T2), or any successor system, is open for settlement of payments in EUR.

Relevant Party” has the meaning given to it in Schedule I (Information and Visits).

Relevant Period” means each period of 12 (twelve) months ending on or about the last day of the financial year.

Relevant Person” means, with respect to any Obligor, any member of its management bodies; or any person acting for it, on its behalf or under its control, having the power to give directions and/or exercise control with respect to the Credit, the Loan or the Investment.

Repeating Representations” means each of the representations set out in Schedule G (Representations and Warranties) other than those Paragraphs thereof which are identified with the words “(Non-repeating)” at the end of the Paragraphs.

Sanctioned Person” means any individual or entity (for the avoidance of doubt, the term entity includes, but is not limited to, any government, group or terrorist organisation) who is a designated target of, or who is otherwise a subject of, Sanctions (including, without limitation, as a result of being owned or otherwise controlled, directly or indirectly, by any individual or entity, who is a designated target of, or who is otherwise a subject of, Sanctions).

Sanctions” means the economic or financial sanctions laws, regulations, trade embargoes or other restrictive measures (including, in particular, but not limited to, measures in relation to the financing of terrorism) enacted, administered, implemented and/or enforced from time to time by any of the following:

 

  (a)

the United Nations, including, inter alia, the United Nations Security Council;

 

  (b)

the European Union, including, inter alia, the Council of the European Union and the European Commission, and any other competent bodies/institutions or agencies of the European Union;

 

  (c)

the government of the United States of America, and any department, division, agency, or office thereof, including, inter alia, the Office of Foreign Asset Control (OFAC) of the United States Department of the Treasury, the United States Department of State and/or the United States Department of Commerce; and

 

  (d)

the government of the United Kingdom, and any department, division, agency, office or authority, including, inter alia, the Office of Financial Sanctions Implementation of His Majesty’s Treasury and the Department for International Trade of the United Kingdom.

Security” means any mortgage, pledge, lien, charge, assignment, hypothecation, or other security interest securing any obligation of any person or any other agreement or arrangement having a similar effect.

 

16


Social Matters” means all, or any of, the following:

 

  (a)

labour and working conditions;

 

  (b)

occupational health and safety;

 

  (c)

rights and interests of vulnerable groups;

 

  (d)

rights and interests of indigenous peoples;

 

  (e)

gender equality;

 

  (f)

public health, safety and security;

 

  (g)

avoidance of forced evictions and alleviation of hardship arising from involuntary resettlement; and

 

  (h)

stakeholder engagement.

Subsidiary” means an entity of which the Parent has direct or indirect control or owns directly or indirectly more than 50% (fifty per cent.) of the voting capital or similar right of ownership and ‘control’ for this purpose means the power to direct the management and the policies of the entity, whether through the ownership of voting capital, by contract or otherwise.

Tax” means any tax, levy, impost, duty or other charge or withholding of a similar nature (including any penalty or interest payable in connection with any failure to pay or any delay in paying any of the same).

Technical Description” has the meaning given to it in Recital (A).

Total Assets” means the total consolidated assets of the Group, as shown in the Parent’s latest consolidated financial statements, as at the end of any Relevant Period.

Trade Payables” means amounts owed by a Goup Company to suppliers following the purchase of products or services, and payable in the short term.

Trade Receivables” means amounts owed by clients to a Group Company following the sale of products or services, and to be paid in the short term.

Trading Day” means a day on which the principal Trading Market is open for trading.

Trading Market” means the following markets or exchanges on which the common stock of the Parent is listed or quoted for trading on the date in question: the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange, OTCQB, OTCQX or Pink Open Market (or any successors to any of the foregoing).

Tranche” means each disbursement made or to be made under this Contract consisting of Tranche A, Tranche B and Tranche C. In the event that no Disbursement Acceptance has been received, Tranche shall mean a Tranche as offered under Article 2.2.2. (Disbursement Offer).

Tranche A” means the first Tranche in the amount set out in paragraph (a) of Article 2.2.1 (Tranches), in relation to which warrants are granted to the Bank in accordance with the Warrant Issuance Agreement and a PIK Interest Rate shall be paid in accordance with Article 4.1 (Payment in Kind (PIK) Interest).

Tranche A Warrant Agreement” means the warrant agreement to be issued to the Bank in connection with disbursement of Tranche A pursuant to the terms of the Warrant Issuance Agreement.

Tranche B” means the second Tranche in the amount set out in paragraph (b) of Article 2.2.1 (Tranches), in relation to which warrants are granted to the Bank in accordance with the Warrant Issuance Agreement and a PIK Interest Rate shall be paid in accordance with Article 4.1 (Payment in Kind (PIK) Interest).

Tranche B Warrant Agreement” means the warrant agreement to be issued to the Bank in connection with disbursement of Tranche B pursuant to the terms of the Warrant Issuance Agreement.

 

17


Tranche C” means the third Tranche in the amount set out in paragraph (c) of Article 2.2.1 (Tranches), in relation to which warrants are granted to the Bank in accordance with the Warrant Issuance Agreement and a PIK Interest Rate shall be paid in accordance with Article 4.1 (Payment in Kind (PIK) Interest).

Tranche C Warrant Agreement” means the warrant agreement to be issued to the Bank in connection with disbursement of Tranche C pursuant to the terms of the Warrant Issuance Agreement.

US” or “United States” means the United States of America, its territories, possessions and other areas subject to the jurisdiction of the United States of America.

USD” or “United States dollar” denotes that lawful currency of the United States of America.

Voluntary Non-EIB Prepayment Event” means a voluntary prepayment by the Borrower or a Guarantor (for the avoidance of doubt, prepayment shall include a repurchase, redemption or cancellation where applicable) of a part or the whole of any Non-EIB Financing, unless such prepayment is made out of the proceeds of a loan or other indebtedness having a term at least equal to the unexpired term of the Non-EIB Financing prepaid.

Warrant Agreements” means the Tranche A Warrant Agreement, the Tranche B Warrant Agreement, and the Tranche C Warrant Agreement.

Warrant Issuance Agreement” means the warrant issuance agreement with respect to the right to receive certain warrants entitling the Bank (or its permitted successors or assignees) to purchase shares in the share capital of the Parent, to be entered into between the Parent as the company and the Bank as the original warrantholder, in form and substance satisfactory to the Bank.

ARTICLE 2

Credit and Disbursements

 

2.1

Amount of Credit

By this Contract the Bank establishes in favour of the Borrower, and the Borrower accepts, a credit in an aggregate amount of up to EUR 37,500,000 (thirty-seven million five hundred thousand euro) for the financing of the Investment (the “Credit”).

 

2.2

Disbursement procedure

 

2.2.1

Tranches

The Bank shall disburse the Credit in 3 (three) Tranches, as set out below:

 

  (a)

Tranche A, in an amount of EUR 10,000,000 (ten million euro);

 

  (b)

Tranche B, in an amount of EUR 12,500,000 (twelve million five hundred thousand euro); and

 

  (c)

Tranche C, in an amount of EUR 15,000,000 (fifteen million euro).

Each Tranche may only be disbursed in full.

 

2.2.2

Disbursement Offer

Upon request by the Borrower and subject to Article 2.5 (Conditions of Disbursement), provided that no event mentioned in sub-paragraph (c) of Article 2.6 (Cancellation) has occurred and is continuing, the Bank shall send to the Borrower a Disbursement Offer for the disbursement of a Tranche. The latest time for receipt by the Borrower of a Disbursement Offer is 6 (six) Business Days before the Final Availability Date. The Disbursement Offer shall specify:

 

  (a)

the amount of the Tranche;

 

18


  (b)

the Disbursement Date, which shall be a Relevant Business Day, falling at least 6 (six) Business Days after the date of the Disbursement Acceptance and on or before the Final Availability Date;

 

  (c)

the interest rate basis of the Tranche, namely:

 

  (i)

the PIK Interest Rate applicable to such Tranche and

 

  (ii)

the Payment Dates and interest periods;

 

  (d)

the Maturity Date;

 

  (e)

the Disbursement Acceptance Deadline; and

 

  (f)

the relevant number of shares of common stock of the Parent issuable pursuant to the terms of the Warrant Agreement applicable to such Tranche.

 

2.2.3

Disbursement Acceptance

 

  (a)

The Borrower may accept a Disbursement Offer by delivering a Disbursement Acceptance to the Bank no later than the Disbursement Acceptance Deadline, which shall in any case be at least 6 (six) Business Days before the Disbursement Date. The Disbursement Acceptance shall be signed by an Authorised Signatory with individual representation rights or 2 (two) or more Authorised Signatories with joint representation right and shall specify the Disbursement Account to which disbursement of the Tranche should be made in accordance with Article 2.3 (Disbursement Account).

 

  (b)

If a Disbursement Offer is duly accepted by the Borrower in accordance with its terms on or before the Disbursement Acceptance Deadline, and provided the conditions in Article 2.5.3 (All Tranches – Other Conditions) are met, the Bank shall make the Accepted Tranche available to the Borrower in accordance with the relevant Disbursement Offer and subject to the terms and conditions of this Contract.

 

  (c)

The Borrower shall be deemed to have refused any Disbursement Offer which has not been duly accepted in accordance with its terms on or before the Disbursement Acceptance Deadline, in which case the Tranche shall not be made available to the Borrower by the Bank, and the Credit shall not be affected.

 

  (d)

The Bank may rely on the information set out in the most recent List of Authorised Signatories and Accounts provided to the Bank by the Borrower. If a Disbursement Acceptance is signed by a person defined as Authorised Signatory under the most recent List of Authorised Signatories and Accounts provided to the Bank by the Borrower, the Bank may assume that such person has the power to sign and deliver in the name and on behalf of the Borrower such Disbursement Acceptance.

 

2.3

Disbursement Account

 

  (a)

Disbursement shall be made to the Disbursement Account specified in the relevant Disbursement Acceptance, provided that such Disbursement Account is acceptable to the Bank.

 

  (b)

Only one Disbursement Account may be specified for each Tranche.

 

2.4

Currency of disbursement

The Bank shall disburse each Tranche in EUR.

 

2.5

Conditions of Disbursement

 

2.5.1

Initial Documentary Conditions Precedent

No Disbursement Offer in respect of Tranche A will be provided by the Bank under this Contract unless the Bank has confirmed that it has received in form and substance satisfactory to it no later than the date falling 10 (ten) Business Days before the Disbursement Date all of the documents and other evidence listed in Schedule F (Initial Documentary Conditions Precedent).

 

19


2.5.2

All Tranches - Documentary Conditions Precedent

No Disbursement Offer, including the first Disbursement Offer, will be provided by the Bank under this Contract unless the Bank has confirmed that it has received, in form and substance satisfactory to it no later than the date falling 10 (ten) Business Days before the Disbursement Date:

 

  (a)

a certificate from the Borrower in the form of Schedule D (Form of Drawdown Certificate), signed by an Authorised Signatory(ies) and dated no earlier than the date falling 14 (fourteen) Business Days before the Disbursement Date;

 

  (b)

evidence of the Borrower’s solvency position on the basis of an up-to-date transcript from the Danish Business Authority; and

 

  (c)

evidence of any Guarantor’s solvency position in the form of a Guarantor’s solvency certificate in which the relevant Guarantor makes representation about its solvency and (if available in a given jurisdiction) attaches to it relevant evidence of such solvency status from competent public registers.

 

2.5.3

All Tranches – Other Conditions

The Bank will only be obliged to make any Accepted Tranche available to the Borrower if on the Disbursement Date for the proposed Tranche:

 

  (a)

the Repeating Representations are correct in all respects; and

 

  (b)

no event or circumstance which constitutes or would with the passage of time or the giving of notice or the making of any determination under this Contract (or any combination of the foregoing) constitute:

 

  (i)

an Event of Default; or

 

  (ii)

a Prepayment Event other than pursuant to Article 5.3.1 (Investment Cost Reduction Event),

has occurred and is continuing unremedied or unwaived or would result from the disbursement of the proposed Tranche.

 

2.5.4

Tranche A – Additional Conditions Precedent

Without prejudice to the generality of Articles 2.5.1 (Initial Documentary Conditions Precedent) to 2.5.3 (All Tranches – Other Conditions), no Disbursement Offer will be provided by the Bank under this Contract in respect of Tranche A unless the Bank has confirmed that it has received in form and substance satisfactory to it, no earlier than the date falling 15 (fifteen) Business Days, and no later than the date falling 10 (ten) Business Days, before the Disbursement Date, and in any event at least 5 (five) Trading Days after any Material Press Release, the execution by the Parent and delivery to the Bank of the Tranche A Warrant Agreement in accordance with the Warrant Issuance Agreement.

 

2.5.5

Tranche B – Additional Conditions Precedent

Without prejudice to the generality of Articles 2.5.1 (Initial Documentary Conditions Precedent) to 2.5.3 (All Tranches – Other Conditions), no Disbursement Offer will be provided by the Bank under this Contract in respect of Tranche B unless Tranche A has been disbursed in full and the Bank has confirmed that it has received in form and substance satisfactory to it no earlier than the date falling 15 (fifteen) Business Days, and no later than the date falling 10 (ten) Business Days, before the Disbursement Date, and in any event at least 5 (five) Trading Days after any Material Press Release:

 

  (a)

the execution by the Parent and delivery to the Bank of the Tranche B Warrant Agreement in accordance with the Warrant Issuance Agreement; and

 

  (b)

either:

 

  (i)

evidence of positive phase III study in first line advanced melanoma study with IO102-IO103 on the full population of the study (i.e. documentation of having achieved statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the treatment arm); or

 

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  (ii)

evidence of positive phase II study in another indication (e.g. first line Metastatic solid tumors such as NSCLC, or SCCHN, or Neo-adjuvant / Adjuvant solid tumors in Melanoma or SCCHN) and as further set out in either one of Paragaphs 1 to 4 of Schedule J (Positive Phase II Study).

 

2.5.6

Tranche C – Additional Conditions Precedent

Without prejudice to the generality of Articles 2.5.1 (Initial Documentary Conditions Precedent) to 2.5.3 (All Tranches – Other Conditions), no Disbursement Offer will be provided by the Bank under this Contract in respect of Tranche C unless Tranche B has been disbursed in full and the Bank has confirmed that it has received in form and substance satisfactory to it no earlier than the date falling 15 (fifteen) Business Days, and no later than the date falling 10 (ten) Business Days, before the Disbursement Date, and in any event at least 5 (five) Trading Days after any Material Press Release:

 

  (a)

the execution by the Parent and delivery to the Bank of the Tranche C Warrant Agreement in accordance with the Warrant Issuance Agreement;

 

  (b)

evidence that at least USD 50,000,000 in cash has been injected into or received by the Parent after the date of this Contract through the issuance of new shares in the Parent or through payments to the Parent or the Borrower from partnerships; and

 

  (c)

evidence that the Borrower has:

 

  (i)

submitted regulatory application for marketing approval in the United States or the European Union based on positive phase III study in first line advanced melanoma study IO102-IO103 either based on interim analysis for accelerated approval in the United States or based on the full population of the study for standard approval in the United States or the European Union; or

 

  (ii)

submitted a regulatory application for market authorisation for earlier lines of melanoma treatment (i.e. neoadjuvant or adjuvant setting) in the United States or the European Union.

 

2.6

Cancellation

 

  (a)

The Borrower may send a written notice to the Bank requesting a cancellation of the undisbursed Credit or a portion thereof. In its written notice the Borrower:

 

  (i)

must specify whether the Credit shall be cancelled in whole or in part and, if in part, the amount of the Credit to be cancelled; and

 

  (ii)

must not request any cancellation of an Accepted Tranche which has a Disbursement Date falling within 5 (five) Business Days of the date of such written notice.

Upon receipt of such written notice, the Bank shall cancel the requested portion of the Credit with immediate effect.

 

  (b)

No part of Tranche A or Tranche B may be cancelled pursuant to sub-paragraph (a) above unless no part of Tranche C is available for disbursement under this Contract and no part of Tranche A may be cancelled pursuant to sub-paragraph (a) above unless no part of Tranche B and Tranche C is available for disbursement under this Contract.

 

  (c)

At any time upon the occurrence of the following events, the Bank may notify the Borrower in writing that the undisbursed portion of the Credit shall be cancelled in whole or in part:

 

  (i)

a Prepayment Event, which for the avoidance of doubt and only in case of an event pursuant to Article 5.3.1 (Investment Cost Reduction Event) or 5.3.4 (Voluntary Non-EIB Prepayment Event), by an amount equal to the amount by which it is entitled to cancel the Credit;

 

  (ii)

an Event of Default; or

 

21


  (iii)

an event or circumstance which would, with the passage of time or the giving of notice or the making of any determination under this Contract (or any combination of the foregoing) constitute a Prepayment Event other than pursuant to Article 5.3.1 (Investment Cost Reduction Event) or an Event of Default.

On the date of such written notification from the Bank the relevant undisbursed portion of the Credit shall be cancelled with immediate effect.

 

2.7

Fee for cancellation of an Accepted Tranche

 

  (a)

If pursuant to sub-paragraph (a) of Article 2.6 (Cancellation) the Borrower cancels an Accepted Tranche, the Borrower shall pay to the Bank the Cancellation Fee.

 

  (b)

If pursuant to sub-paragraph (c) of Article 2.6 (Cancellation) the Bank cancels all or part of an Accepted Tranche, the Borrower shall pay to the Bank the Cancellation Fee.

 

  (c)

If an Accepted Tranche is not disbursed on the Disbursement Date because the conditions precedent set out in Article 2.5.3 (All Tranches – Other Conditions) are not satisfied on such date, such Tranche shall be cancelled and the Borrower shall pay to the Bank the relevant Cancellation Fee.

 

2.8

Cancellation after expiry of the Credit

On the day following the Final Availability Date, unless otherwise specifically notified in writing by the Bank to the Borrower, any part of the Credit in respect of which no Disbursement Acceptance has been received in accordance with Article 2.2.3 (Disbursement Acceptance) shall be automatically cancelled, without any further notice from the Bank to the Borrower.

 

2.9

Drop Dead Fees

 

  (a)

If no disbursement of Tranche A has been made within 6 (six) months from the date of this Contract or in case the Credit is cancelled in full under Article 2.6 (Cancellation) prior to the expiry of such term, the Borrower shall pay to the Bank a one-off contractual fee equal to 1% (one hundred basis points) of Tranche A.

 

  (b)

If no disbursement of Tranche B has been made on the Final Availability Date and provided that that the technical condition precedent applicable to Tranche B set out in sub-paragraph (b) of Article 2.5.5 (Tranche B – Additional Conditions Precedent) has been satisfied, the Borrower shall pay to the Bank a one-off contractual fee equal to 1% (one hundred basis points) of Tranche B.

 

  (c)

If no disbursement of Tranche C has been made on the Final Availability Date and provided that that the conditions precedent applicable to Tranche C set out in sub-paragraphs (b) and (c) of Article 2.5.6 (Tranche C—Additional Conditions Precedent) have been satisfied, the Borrower shall pay to the Bank a one-off contractual fee equal to 1% (one hundred basis points) of Tranche C.

 

  (d)

In case of cancellation of Tranche B and/or Tranche C under paragraph (a) of Article 2.6 (Cancellation) on or prior to the Final Availability Date, the Borrower shall pay to the Bank a one-off contractual fee equal to 1% (one hundred basis points) of the cancelled amount.

 

  (e)

The fees payable under this Article 2.9 (Drop Dead Fees) (the “Drop Dead Fees”) shall be payable by the Borrower to the Bank in EUR within 15 (fifteen) days of the Borrower’s receipt of the Bank’s demand or within any longer period specified in the Bank’s demand.

 

  (f)

For the avoidance of doubt, the Drop Dead Fees payable under this Article 2.9 (Drop Dead Fees) are independent of any other fees stipulated in this Contract.

 

2.10

Sums due under Article 2

Sums due under Article 2.6 (Cancellation) shall be payable in EUR. Sums due under Article 2.6 (Cancellation) shall be payable within 15 (fifteen) days of the Borrower’s receipt of the Bank’s demand or within any longer period specified in the Bank’s demand.

 

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ARTICLE 3

The Loan

 

3.1

Amount of Loan

The Loan shall comprise the aggregate amount of Tranches disbursed by the Bank under the Credit.

 

3.2

Currency of repayment, interest and other charges

 

  (a)

The Borrower shall pay interest, principal and other charges payable in respect of each Tranche in EUR.

 

  (b)

Any other payment shall be made in the currency specified by the Bank having regard to the currency of the expenditure to be reimbursed by means of that payment.

ARTICLE 4

Interest

 

4.1

Payment in Kind (PIK) Interest

Interest shall accrue on the outstanding balance of each Tranche at the PIK Interest Rate, calculated on the basis of Article 6.1 (Day count convention). Such interest shall be capitalised on each Payment Date in respect of the relevant Tranche and added to the outstanding principal amount of the Loan. Any such accrued interest shall, after being so capitalised, be treated as part of the principal amount of that Loan, shall bear all interest in accordance with this Article 4 (Interest) and shall be payable on the Maturity Date of such Tranche or, where a Tranche is prepaid, on the Prepayment Date.

 

4.2

Warrants

In addition to the interest payable pursuant to Article 4.1 (Payment in Kind (PIK) Interest) above, the Bank shall be entitled to receive any amounts due under the Warrant Issuance Agreement or the Warrant Agreements.

 

4.3

Interest on overdue sums

Without prejudice to Article 9 (Events of default), if the Borrower fails to pay any amount payable by it under this Contract on its due date, or if the Parent fails to pay any amount payable by it under the Warrant Issuance Agreement, interest shall accrue on any such overdue amount from the due date to the date of actual payment at an annual rate equal to:

 

  (a)

for overdue sums related to each Tranche, the higher of:

 

  (i)

the applicable PIK Interest Rate plus 2% (two hundred basis points); or

 

  (ii)

EURIBOR plus 2% (two hundred basis points); or

 

  (b)

for overdue sums other than under sub-paragraph (a) of Article 4.3 (Interest on overdue sums) above, EURIBOR plus 2% (two hundred basis points),

and shall be payable in accordance with the demand of the Bank. For the purpose of determining EURIBOR in relation to this Article 4.3 (Interest on overdue sums), the relevant periods within the meaning of Schedule B (Definition of EURIBOR) shall be successive periods of 1 (one) month commencing on the due date.

If the overdue sum is in a currency other than EUR, the relevant interbank rate, or, as determined by the Bank, the relevant risk-free rate that is generally retained by the Bank for transactions in that currency plus 2% (two hundred basis points) shall apply, calculated in accordance with the market practice for such rate.

 

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ARTICLE 5

Repayment

 

5.1

Single instalment

The Borrower shall repay each Tranche, together with all other amounts outstanding under this Contract in relation to that Tranche, in a single instalment on the Maturity Date of that Tranche.

 

5.2

Voluntary prepayment

 

5.2.1

Prepayment option

 

  (a)

Subject to Articles 5.2.2 (Prepayment Fee) and 5.4 (General), the Borrower may prepay all or part of any Tranche, together with accrued interest (including any interest under Article 4.1 (Payment in Kind (PIK) Interest)), any Prepayment Fee and indemnities if any and any amount due under any Finance Document in connection to such Tranche, upon giving a Prepayment Request with at least 30 (thirty) calendar days prior notice specifying:

 

  (i)

the Prepayment Amount;

 

  (ii)

the Prepayment Date, which shall be a Payment Date; and

 

  (iii)

the Contract Number.

 

  (b)

The Prepayment Request shall be irrevocable.

 

5.2.2

Prepayment Fee

If the Borrower prepays a Tranche, the Borrower shall pay the relevant Prepayment Fee on the Prepayment Date.

 

5.2.3

Prepayment mechanics

Upon presentation by the Borrower to the Bank of a Prepayment Request, the Bank shall issue a Prepayment Notice to the Borrower, not later than 15 (fifteen) days prior to the Prepayment Date. The Prepayment Notice shall specify the Prepayment Amount, the accrued interest due thereon, and the Prepayment Fee. If the Prepayment Notice specifies the Prepayment Fee, it shall also specify the deadline by which the Borrower may accept the Prepayment Notice, and the Borrower must accept the Prepayment Notice no later than such deadline as a condition to prepayment.

The Borrower shall make a prepayment in accordance with the Prepayment Notice and shall accompany the prepayment by the payment of accrued interest (including any interest under Article 4.1 (Payment in Kind (PIK) Interest)) and Prepayment Fee or indemnity, if any, due on the Prepayment Amount, as specified in the Prepayment Notice, and shall identify the Contract Number in the prepayment transfer.

 

5.3

Compulsory prepayment and cancellation

 

5.3.1

Investment Cost Reduction Event

 

  (a)

The Borrower shall promptly inform the Bank if an Investment Cost Reduction Event has occurred or is likely to occur. At any time after the occurrence of an Investment Cost Reduction Event the Bank may, by notice to the Borrower, cancel the undisbursed portion of the Credit and/or demand prepayment of the Loan Outstanding, in either case, up to the amount by which the Credit exceeds the limits referred to in paragraph (b) below together with accrued interest and all other amounts accrued and outstanding under this Contract or any other Finance Document in relation to the proportion of the Loan Outstanding to be prepaid.

 

24


  (b)

For the purpose of this Article, “Investment Cost Reduction Event” means that the total cost of the Investment at completion by the final date specified in the Technical Description falls below the figure stated in Recital (A) so that the amount of the Credit exceeds:

 

  (i)

50% (fifty per cent.);

 

  (ii)

when aggregated with the amount of any other funds from the European Union made available for the Investment, 70% (seventy per cent.); or

 

  (iii)

when aggregated with the principal amount of any loan provided by another implementing partner under the InvestEU Fund to finance the Investment, 50% (fifty per cent.),

of such total cost of the Investment.

 

5.3.2

Change Events

The Borrower shall promptly inform the Bank if:

 

  (a)

a Change-of-Control Event has occurred; or

 

  (b)

a Change-of-Law Event has occurred or is likely to occur.

In such case, the Borrower shall, on request of the Bank, consult with the Bank as to the impact of such event. If a Change-of-Control Event has occurred or a Change-of-Law Event has occurred or is likely to occur, the Bank may by notice to the Borrower, cancel the undisbursed portion of the Credit and/or demand prepayment of the Loan Outstanding, together with accrued interest and all other amounts accrued or outstanding under this Contract or any other Finance Document.

 

5.3.3

Illegality Event

 

  (a)

Upon becoming aware of an Illegality Event:

 

  (i)

the Bank shall promptly notify the Borrower, and

 

  (ii)

the Bank may immediately (A) suspend or cancel the undisbursed portion of the Credit, and/or (B) demand prepayment of the Loan Outstanding, together with accrued interest and all other amounts accrued and outstanding under this Contract or any other Finance Document on the date indicated by the Bank in its notice to the Borrower.

 

  (b)

For the purposes of this Article, “Illegality Event” means that it becomes unlawful in any applicable jurisdiction, or if it becomes contrary to any Sanctions, for the Bank to:

 

  (i)

perform any of its obligations as contemplated in this Contract; or

 

  (ii)

fund or maintain the Loan.

 

5.3.4

Voluntary Non-EIB Prepayment Event

 

  (a)

The Borrower shall promptly inform the Bank if a Voluntary Non-EIB Prepayment Event has occurred or is likely to occur. At any time after the occurrence of a Voluntary Non-EIB Prepayment Event the Bank may, by notice to the Borrower, cancel the undisbursed portion of the Credit and demand prepayment of the Loan Outstanding, together with accrued interest and all other amounts accrued and outstanding under this Contract or any other Finance Document in relation to the proportion of the Loan Outstanding to be prepaid.

 

  (b)

The proportion of the Credit that the Bank may cancel and the proportion of the Loan Outstanding that the Bank may require to be prepaid shall be the same as the proportion that the prepaid amount of the Non-EIB Financing bears to the aggregate outstanding amount of all Non-EIB Financing.

 

5.3.5

Disposals

If any Group Company disposes of assets forming part of the Investment or shares in subsidiaries holding assets forming part of the Investment, without the approval of the Bank, the Borrower shall apply all proceeds of such disposal to prepay the Loan Outstanding (in part or in whole), together with accrued interest, promptly following receipt of such proceeds in accordance with sub-paragraph (b) of Paragraph 7 (Disposal of assets) of Schedule H (General Undertakings).

 

25


5.3.6

Prepayment Fee

In the case of a Prepayment Event (other than pursuant to (i) a Change-of-Law Event under Article 5.3.2 (Change Events), or (ii) Article 5.3.3 (Illegality Event)) in relation to a Tranche, the Borrower shall pay a prepayment fee in an amount equal to 50% of the relevant Prepayment Fee.

 

5.3.7

Prepayment mechanics

Any sum demanded by the Bank pursuant to Articles 5.3.1 (Investment Cost Reduction Event) to 5.3.4 (Voluntary Non-EIB Prepayment Event) shall be paid on the date indicated by the Bank in its notice of demand, such date being a date falling not less than 30 (thirty) days from the date of the demand (or, if earlier, the last day of any applicable grace period permitted by law in respect of the event in Article 5.3.3 (Illegality Event)).

 

5.4

General

 

  (a)

A repaid or prepaid amount may not be reborrowed.

 

  (b)

If the Borrower prepays a Tranche on a date other than a relevant Payment Date, under Article 5.2 (Voluntary prepayment), or if the Bank exceptionally accepts, solely upon the Bank’s discretion, a Prepayment Request with prior notice of less than 30 (thirty) calendar days, the Borrower shall pay to the Bank an administrative fee in such an amount as the Bank shall notify to the Borrower.

ARTICLE 6

Payments

 

6.1

Day count convention

Any amount due under this Contract and calculated in respect of a fraction of a year shall be determined based on a year of 360 (three hundred and sixty) days and a month of 30 (thirty) days.

 

6.2

Time and place of payment

 

  (a)

If neither this Contract nor the Bank’s demand specifies a due date, all sums other than sums of interest, indemnity and principal are payable within 15 (fifteen) days of the Borrower’s receipt of the Bank’s demand.

 

  (b)

Each sum payable by the Borrower under this Contract shall be paid to the following account:

or such other account notified by the Bank to the Borrower.

 

  (c)

The Borrower shall provide the Contract Number as a reference for each payment made under this Contract.

 

26


  (d)

Any disbursements by and payments to the Bank under this Contract shall be made using the Disbursement Account (for disbursements by the Bank) and the Payment Account (for payments to the Bank).

 

6.3

No set-off by the Borrower

All payments to be made by the Borrower under this Contract shall be calculated and be made without (and free and clear of any deduction for) set-off or counterclaim.

 

6.4

Disruption to Payment Systems

If either the Bank determines (in its discretion) that a Disruption Event has occurred or the Bank is notified by the Borrower that a Disruption Event has occurred:

 

  (a)

the Bank may, and shall if requested to do so by the Borrower, consult with the Borrower with a view to agreeing with the Borrower such changes to the operation or administration of this Contract as the Bank may deem necessary in the circumstances;

 

  (b)

the Bank shall not be obliged to consult with the Borrower in relation to any changes mentioned in sub-paragraph (a) above if, in its opinion, it is not practicable to do so in the circumstances and, in any event, shall have no obligation to agree to such changes; and

 

  (c)

the Bank shall not be liable for any damages, costs or losses whatsoever arising as a result of a Disruption Event or for taking or not taking any action pursuant to or in connection with this Article 6.4 (Disruption to Payment Systems).

 

6.5

Application of sums received

 

6.5.1

General

Sums received from the Borrower shall only discharge its payment obligations if and when received in accordance with the terms of this Contract.

 

6.5.2

Partial payments

If the Bank receives a payment that is insufficient to discharge all the amounts then due and payable by the Borrower under this Contract, the Bank shall apply that payment in or towards payment of:

 

  (a)

first, any unpaid fees, costs, indemnities and expenses due under this Contract;

 

  (b)

secondly, any accrued interest due but unpaid under this Contract;

 

  (c)

thirdly, any principal due but unpaid under this Contract; and

 

  (d)

fourthly, any other sum due but unpaid under this Contract.

 

6.5.3

Allocation of sums related to Tranches

In case of receipt of sums which cannot be identified as applicable to a specific Tranche, and on which there is no agreement between the Bank and the Borrower on their application, the Bank may apply these between Tranches at its discretion.

ARTICLE 7

Borrower undertakings and representations

 

7.1

Representations and Warranties

 

  (a)

The Borrower makes the representations and warranties set out in Schedule G (Representations and Warranties) to the Bank on the date of this Contract in respect of itself and, where applicable, the other Obligors.

 

27


  (b)

The Repeating Representations are deemed to be made by the Borrower (in respect of itself and, where applicable, the other Obligors) on the date of each Disbursement Acceptance, each Disbursement Date and each Payment Date by reference to the facts and circumstances then existing.

 

7.2

Undertakings

The undertakings in Schedule H (General Undertakings) and Schedule I (Information and Visits) remain in force from the date of this Contract for so long as any amount is outstanding under this Contract or the Credit is available.

ARTICLE 8

Charges and expenses

 

8.1

Taxes, duties and fees

The Borrower shall, or/and shall ensure that the relevant Obligor will, pay all Taxes, duties, fees and other impositions of whatsoever nature, including stamp duty and registration fees, arising out of the execution or implementation of each Finance Document or any related document and in the creation, perfection, registration or enforcement of any Security for the Loan to the extent applicable.

The Borrower shall, or/and shall ensure that the relevant Obligor will, pay all principal, interest, indemnities and other amounts due under this Contract or any other Finance Document gross without any withholding or deduction of any national or local impositions whatsoever, provided that if the Borrower or the relevant Obligor (as applicable) is required by law or an agreement with a governmental authority or otherwise to make any such withholding or deduction, it will gross up the payment to the Bank so that after withholding or deduction, the net amount received by the Bank is equivalent to the sum due.

 

8.2

Other charges

The Borrower shall bear all charges and expenses, including professional, legal, banking or exchange charges incurred in connection with the preparation, execution, implementation, enforcement and termination of the Finance Documents (including, but not limited to, any Guarantee Agreement entered into pursuant to Paragraph 16 (Guarantees) of Schedule H (General Undertakings)) or any related document, any amendment, supplement or waiver in respect of the Finance Documents or any related document, and in the amendment, creation, management, enforcement and realisation of any Security for the Loan.

 

8.3

Increased costs, indemnity and set-off

 

  (a)

The Borrower shall pay to the Bank any costs or expenses incurred or suffered by the Bank as a consequence of the introduction of or any change in (or in the interpretation, administration or application of) any law or regulation or compliance with any law or regulation which occurs after the date of this Contract, in accordance with or as a result of which (i) the Bank is obliged to incur additional costs in order to fund or perform its obligations under this Contract, or (ii) any amount owed to the Bank under this Contract or the financial income resulting from the granting of the Credit or the Loan by the Bank to the Borrower is reduced or eliminated.

 

  (b)

Without prejudice to any other rights of the Bank under this Contract or under any applicable law, the Borrower shall indemnify and hold the Bank harmless from and against any loss incurred as a result of any full or partial discharge that takes place in a manner other than as expressly set out in this Contract.

 

28


  (c)

The Bank may set off any matured obligation due from the Borrower under each Finance Document (to the extent beneficially owned by the Bank) against any obligation (whether or not matured) owed by the Bank to the Borrower regardless of the place of payment, booking branch or currency of either obligation. If the obligations are in different currencies, the Bank may convert either obligation at a market rate of exchange in its usual course of business for the purpose of the set-off. If either obligation is unliquidated or unascertained, the Bank may set off in an amount estimated by it in good faith to be the amount of that obligation.

ARTICLE 9

Events of default

 

9.1

Right to demand repayment

The Bank may demand (in writing) without prior notice or any judicial or extra judicial step immediate repayment by the Borrower of all or part of the Loan Outstanding (as requested by the Bank), together with accrued interest, any Prepayment Fee and all other accrued or outstanding amounts under this Contract or any other Finance Document, if:

 

  (a)

any amount payable pursuant to any Finance Document is not paid on the due date at the place and in the currency in which it is expressed to be payable, unless:

 

  (i)

its failure to pay is caused by an administrative or technical error or a Disruption Event; and

 

  (ii)

payment is made within 3 (three) Business Days of its due date;

 

  (b)

any information or document given to the Bank by or on behalf of any Obligor or any representation, warranty or statement made or deemed to be made by the Borrower in, pursuant to or for the purposes of entering into any Finance Document or in connection with the negotiation or performance of any Finance Document is or proves to have been incorrect, incomplete or misleading in any material respect;

 

  (c)

following any default of any Obligor in relation to any loan, or any obligation arising out of any financial transaction, other than the Loan:

 

  (i)

such Obligor is required or is capable of being required to prepay, discharge, close out or terminate ahead of maturity such other loan or obligation; or

 

  (ii)

any financial commitment for such other loan or obligation is cancelled or suspended;

and such other loans or obligations or commitments falling under sub-paragraphs (i) and/or (ii) above are in an aggregate principal amount in excess of EUR 50,000 (fifty thousand euro) or its equivalent in any other currency or currencies;

 

  (d)

any Obligor is unable to pay its debts as they fall due, or suspends its debts, or makes or seeks to make a composition with its creditors (excluding the Bank) including a moratorium, or, by reason of financial difficulties, commences negotiations with one or more of its creditors (excluding the Bank) with a view to rescheduling any of its Indebtedness;

 

  (e)

any of the following occurs: (i) the admission by any Obligor of its inability to pay its debts when and as they become due; (ii) the execution by any Obligor of a general assignment for the benefit of creditors; (iii) the filing by or against any Obligor of a petition in bankruptcy or any petition for relief under any bankruptcy, insolvency, or debtor’s relief law, or, in the case of any involuntary filing of a petition against any Obligor, the continuation of such petition without dismissal for a period of sixty (60) days or more; (iv) the appointment of a receiver or trustee to take possession of the property or assets of any Obligor; or (v) any other corporate action, legal proceedings or other procedure or step is taken in relation to the suspension of payments, a moratorium of any indebtedness, dissolution, administration or reorganisation (by way of voluntary arrangement, scheme of arrangement or otherwise) or an order is made or an effective resolution is passed for the winding up of any Obligor, or if any Obligor is declared insolvent or ceases or resolves to cease to carry on the whole or any substantial part of its business or activities or any situation similar to any of the above occurs under any applicable law, unless such action, proceeding or procedure is frivolous or vexatious and is discharged, stayed or dismissed within 30 (thirty) days of commencement;

 

29


  (f)

an encumbrancer takes possession of, or a receiver, liquidator, administrator, administrative receiver or similar officer is appointed, whether by a court of competent jurisdiction or by any competent administrative authority or by any person, of or over, any part of the business or assets of any Obligor or any property forming part of the Investment;

 

  (g)

any Obligor defaults in the performance of any obligation in respect of any other loan granted by the Bank or financial instrument entered into with the Bank;

 

  (h)

any Obligor defaults in the performance of any obligation in respect of any other loan or financial instrument made to it from the resources of the Bank or the European Union;

 

  (i)

any distress, execution, sequestration or other process is levied or enforced upon the property of any Obligor or any property forming part of the Investment and is not discharged or stayed within 30 (thirty) days;

 

  (j)

a Material Adverse Change occurs, as compared with the position at the date of this Contract;

 

  (k)

it is or becomes unlawful for any Obligor to perform any of its obligations under the Finance Documents, or any Finance Document is not effective in accordance with its terms or is alleged by any Obligor to be ineffective in accordance with its terms; or

 

  (l)

any Obligor fails to comply with any other provision under the Finance Documents (including, without limitation, each of the undertakings in Schedule A (Investment Specification and Reporting), Schedule H (General Undertakings) and Schedule I (Information and Visits)), unless the non-compliance or circumstance giving rise to the non-compliance is capable of remedy and is remedied within 20 (twenty) Business Days from the earlier of the Borrower becoming aware of the non-compliance and a notice served by the Bank on the Borrower.

 

9.2

Other rights at law

Article 9.1 (Right to demand repayment) shall not restrict any other right of the Bank at law to require prepayment of the Loan Outstanding.

 

9.3

Prepayment Fee

In case of demand under Article 9.1 (Right to demand repayment), the Borrower shall pay the Bank the amount demanded together with the relevant Prepayment Fee.

 

9.4

Non-Waiver

No failure or delay or single or partial exercise by the Bank in exercising any of its rights or remedies under this Contract shall be construed as a waiver of such right or remedy. The rights and remedies provided in this Contract are cumulative and not exclusive of any rights or remedies provided by law.

 

9.5

Automatic Acceleration

If an Event of Default under sub-paragraphs (d), (e) or (f) of Article 9.1 (Right to demand repayment) shall occur in a US court of competent jurisdiction (an “Automatic Acceleration Event”) in respect of the Borrower, then without notice to the Borrower or any other person, or any other act by the Bank or any other person, the Credit shall automatically terminate and the principal of the Loan to the Borrower, together with all accrued interest thereon, and all other amounts owed by the Borrower under the Finance Documents shall become immediately due and payable without presentment, demand, protest or notice of any kind, all of which are expressly waived.

 

30


ARTICLE 10

Law and jurisdiction, miscellaneous

 

10.1

Governing Law

This Contract shall be governed by Danish law (excluding Danish choice of law rules to the extent they would lead to the application of the laws of another jurisdiction).

 

10.2

Jurisdiction

 

  (a)

The courts Denmark (with the Copenhagen City Court (Københavns Byret) as the court of first instance) have exclusive jurisdiction to settle any dispute (a “Dispute”) arising out of or in connection with this Contract (including a dispute regarding the existence, validity or termination of this Contract or the consequences of its nullity).

 

  (b)

The Parties agree that the courts of Denmark are the most appropriate and convenient courts to settle Disputes between them and, accordingly, that they will not argue to the contrary.

 

10.3

Place of performance

Unless otherwise specifically agreed by the Bank in writing, the place of performance under this Contract, shall be the seat of the Bank.

 

10.4

Evidence of sums due

In any legal action arising out of this Contract the certificate of the Bank as to any amount or rate due to the Bank under this Contract shall, in the absence of manifest error, be prima facie evidence of such amount or rate.

 

10.5

Entire Agreement

This Contract constitutes the entire agreement between the Bank and the Borrower in relation to the provision of the Credit hereunder, and supersedes any previous agreement, whether express or implied, on the same matter.

 

10.6

Invalidity

If at any time any term of this Contract is or becomes illegal, invalid or unenforceable in any respect, or this Contract is or becomes ineffective in any respect, under the laws of any jurisdiction, such illegality, invalidity, unenforceability or ineffectiveness shall not affect:

 

  (a)

the legality, validity or enforceability in that jurisdiction of any other term of this Contract or the effectiveness in any other respect of this Contract in that jurisdiction; or

 

  (b)

the legality, validity or enforceability in other jurisdictions of that or any other term of this Contract or the effectiveness of this Contract under the laws of such other jurisdictions.

 

10.7

Amendments

Any amendment to this Contract shall be made in writing and shall be signed by the Parties hereto.

 

10.8

Counterparts

This Contract may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument. Each counterpart is an original, but all counterparts shall together constitute one and the same instrument.

 

31


10.9

Assignment and transfer by the Bank

 

  (a)

Subject to sub-paragraph (b) of this Article 10.9 (Assignment and transfer by the Bank), the consent of the Borrower is required for an assignment or transfer (by way of novation, sub-participation or otherwise) by the Bank of all or part of its rights, benefits or obligations under the Finance Documents, unless the assignment or transfer:

 

  (i)

is to a Bank Affiliate; or

 

  (ii)

is made at a time when an Event of Default has occurred and is continuing; or

 

  (iii)

is made in respect of a sub-participation or securitisation (or similar transaction of broadly equivalent economic effect) where the Bank remains the lender of record of the Loan.

 

  (b)

The consent of the Borrower to an assignment or transfer must not be unreasonably withheld or delayed. The Borrower will be deemed to have given its consent 5 (five) Business Days after the Bank has requested it unless consent is expressly refused by the Borrower within that time.

 

  (c)

The Bank shall have the right to disclose all information relating to or concerning the Borrower, the Group, the Finance Documents and the Loan in connection with or in contemplation of any such assignment or transfer.

 

  (d)

For the purpose of this Article 10.9 (Assignment and transfer by the Bank):

Affiliate” means any entity directly or indirectly Controlling, Controlled by or under common Control with the Bank.

Bank Affiliate” means an Affiliate of the Bank and any other entity or platform initiated, managed or advised by the Bank.

Control” means with respect to a given entity, the power to:

 

  (i)

cast, or control the casting of, votes corresponding to more than 50% of the issued voting share capital of that entity; or

 

  (ii)

appoint or remove all, or the majority, of the directors or other equivalent officers of that entity; or

 

  (iii)

give directions with respect to the operating and financial policies of that entity with which the directors or other equivalent officers of such entity are obliged to comply,

and “Controlling” and “Controlled” have corresponding meanings.

 

10.10

No MNPI or prohibited disclosures

 

  (a)

Notwithstanding anything set out in this Contract (including, but not limited to, in Schedule I (Information and Visits) and in Schedule Schedule H (General Undertakings)), no Group Company shall be required to submit any information to the Bank to the extent:

 

  (i)

such information constitutes confidential information of a third party and disclosure is prohibited by agreement between that Group Company and such third party;

 

  (ii)

such information is not in that Group Company’s possession and is not reasonably obtainable; or

 

  (iii)

this would be contrary to applicable mandatory laws.

 

  (b)

If considered necessary by the Bank and to the extent possible pursuant to applicable laws, the Parties shall cooperate or conclude separate arrangements in order to grant the Bank access to such information or documents that cannot otherwise be provided to the Bank pursuant to paragraph (a) above, specifically resulting from relevant provisions of other confidentiality agreements or relevant laws regulating access to such information or documents.

 

32


  (c)

To the extent any information is disclosed to the Bank and such information constitutes, in the Borrower’s reasonable judgment, material non-public information (“MNPI”), the Borrower shall:

 

  (i)

clearly designate the information as such and the Borrower shall provide notice to the Bank in advance of providing to the Bank any such MNPI;

 

  (ii)

only provide the Bank with such information and only to the persons that the Bank has disclosed to the Borrower as being authorised to receive such information;

 

  (iii)

label the information such that it is clear that the information qualifies as MNPI;

 

  (iv)

clearly designate the information and indicate the sections of the information provided to the Bank that qualify as “MNPI”;

 

  (v)

clearly indicate the basis on which the information is being disclosed to the Bank and confirm that the information has not been unlawfully disclosed; and

 

  (vi)

provide the Bank with information as to the time at which the Borrower expects such information will no longer be classified as MNPI.

 

  (d)

To the extent that the Borrower discloses information to the Bank and does not believe such information constitutes MNPI and the Bank disagrees with the Borrower’s determination, the Bank may submit a request for information reasonably required to understand the rationale behind the Borrower’s determination and the Borrower will provide such information within two (2) Business Days following the Bank’s request for information.

 

  (e)

Without prejudice to the other rights of the Bank set forth in the Finance Documents, the Bank may at any time deliver written notice (an “Opt-out Notice”) to the Borrower requesting that the Bank not receive materials designated as containing MNPI; provided however that such Opt-out Notice may be subsequently revoked by the Bank at any time. Following receipt of an Opt-Out Notice from the Bank (unless subsequently revoked):

 

  (i)

the Borrower shall not deliver, and shall procure that no other Group Company delivers, any MNPI to the Bank, except as required by applicable law; and

 

  (ii)

for the avoidance of doubt, the Borrower shall not be required to deliver any MNPI to the Bank notwithstanding the provisions of this Contract.

 

  (f)

To the extent that the Bank does receive MNPI in accordance with this Contract, the Bank will:

 

  (i)

take all reasonable steps to hold in trust and confidence such MNPI and not use such MNPI for any purpose other than to evaluate its rights under the Finance Documents (the “Purpose”);

 

  (ii)

not disclose such MNPI, except to its Affiliates and its and their employees, consultants, contractors, subcontractors and agents who:

 

  (1)

require access to such MNPI for the Purpose; and

 

  (2)

have been informed of the limitations on use and disclosure of such MNPI created by this Contract;

 

  (iii)

maintain the confidentiality of the MNPI with at least the same degree of care as it maintains the confidentiality of its own confidential information, and in any event, at least a reasonable standard of care; and

 

  (iv)

process any personal data contained in MNPI solely in accordance with applicable data protection legislation.

 

33


ARTICLE 11

Final Articles

 

11.1

Notices

 

11.1.1

Form of notice

 

  (a)

Any notice or other communication given under this Contract must be in writing and, unless otherwise stated, may be made by letter or electronic mail.

 

  (b)

Notices and other communications for which fixed periods are laid down in this Contract or which themselves fix periods binding on the addressee, may be made by hand delivery, registered letter or by electronic mail. Such notices and communications shall be deemed to have been received by the other Party:

 

  (i)

on the date of delivery in relation to a hand-delivered or registered letter; or

 

  (ii)

in the case of any electronic mail, only when such electronic mail is actually received in readable form and only if it is addressed in such a manner as the other Party shall specify for this purpose.

 

  (c)

Any notice provided by the Borrower to the Bank by electronic mail shall:

 

  (i)

mention the Contract Number in the subject line; and

 

  (ii)

be in the form of a non-editable electronic image (pdf, tif or other common non-editable file format agreed between the Parties) of the notice signed by an Authorised Signatory with individual representation right or by two or more Authorised Signatories with joint representation rights of the Borrower as appropriate, attached to the electronic mail.

 

  (d)

Notices issued by the Borrower pursuant to any provision of this Contract shall, where required by the Bank, be delivered to the Bank together with satisfactory evidence of the authority of the person or persons authorised to sign such notice on behalf of the Borrower and the authenticated specimen signature of such person or persons.

 

  (e)

Without affecting the validity of electronic mail notices or communication made in accordance with this Article 11.1 (Notices), the following notices, communications and documents shall also be sent by registered letter to the relevant Party at the latest on the immediately following Business Day:

 

  (i)

Disbursement Acceptance;

 

  (ii)

any notices and communication in respect of the cancellation of a disbursement of any Tranche, Prepayment Request, Prepayment Notice, Event of Default, any demand for prepayment; and

 

  (iii)

any other notice, communication or document required by the Bank.

 

  (f)

The Parties agree that any above communication (including via electronic mail) is an accepted form of communication, shall constitute admissible evidence in court and shall have the same evidential value as an agreement under hand.

 

11.1.2

Addresses

The address and electronic mail address (and the department for whose attention the communication is to be made) of each Party for any communication to be made or document to be delivered under or in connection with this Contract is:

 

For the Bank   

Attention: OPS/EGPF/2-DTLS/LSB

 

100 boulevard Konrad Adenauer

 

L-2950 Luxembourg

 

Luxembourg

 

 

34


For the Borrower   

Attention: CFO

C/O COBIS

Ole Maaløes Vej 3

2200 København N

Denmark

 

11.1.3

Demand after notice to remedy

Each Party shall promptly notify the other Party in writing of any change in their respective communication details.

 

11.2

US Patriot Act

The Bank hereby notifies the Borrower that pursuant to the requirements of the US Patriot Act, the Bank may be required to obtain, verify, and record information that identifies each or any Obligor, which information includes the name and address of such Obligor and other information that will allow the Bank to identify such Obligor in accordance with the US Patriot Act.

 

11.3

English language

 

  (a)

Any notice or communication given under or in connection with this Contract must be in English.

 

  (b)

All other documents provided under or in connection with this Contract must be:

 

  (i)

in English; or

 

  (ii)

if not in English, and if so required by the Bank, accompanied by a certified English translation and, in this case, the English translation will prevail.

 

35


IN WITNESS WHEREOF the Parties hereto have caused this Contract to be executed in 3 (three) originals in the English language.

At Luxembourg and Copenhagen, this 19th December 2024

 

/s/ Maria-Teresa Massaad

Head of Division

 

/s/ Yu Zhang

Head of Division

   /s/ Mai-Britt Zocca

Signed for and on behalf of

 

EUROPEAN INVESTMENT BANK

  

Signed for and on behalf of

 

IO BIOTECH ApS

 

36


Schedule A

Investment Specification and Reporting

A.1 Technical Description

 

A.1.1

Purpose, Location

The Investment finances the Borrower’s R&D expenses over the next 3 years, mainly related to the development of IO102-IO103, IO112 and IO170, as well as pre-clinical stages—discovery programs still for new leads.

The Investment will be managed mainly in Copenhagen, Denmark.

 

A.1.2

Description

The scope of the Investment is to support the development of targeted treatments for various cancers. The Investment cover inter alia R&D costs related to non-clinical studies and clinical trial expenses, the necessary activities to enable regulatory approvals and market access as well as manufacturing, intellectual property and G&A related costs of assets mentioned under A.1.1 (Purpose, Location) above.

 

A.1.3

Calendar

The investment plan is expected to be implemented in 3 (three) years, from 1 September 2024 to 30 September 2027. The investment shall be completed no later than on 30 September 2027.

 

A.1.4

Investment costs

Total project investment costs over the Investment period are estimated to be at least EUR 100,000,000 (one hundred million euro) or its equivalent in another currency or currencies, with the majority of expenditures to be incurred in Europe.

As summarised under A.1.2 (Description) above, financing will cover inter alia:

 

   

the finalisation of the IO102-IO103 clinical studies in advanced melanoma and potentially the initiation of clinical studies in other indications;

 

   

the regulatory approval of IO102-103 and the market access of the product;

 

   

preclinical and clinical studies with IO112, IO 170 as well as potential new products;

 

   

R&D staff costs.

R&D costs are expected to breakdown as follow over the forecasted period:

 

Project Costs (in EURm)

   2024 Q4      2025      2026      2027 Q1-Q3  

Eligible expenses *

     14.4        32.7        29.7        23.2  

 

*

based on the nature of cost described above

 

37


Investment information to be sent to the Bank and method of transmission

A.2 Information Duties

 

A.2.1

Dispatch of information: designation of the person responsible

The information below has to be sent to the Bank under the responsibility of:

 

   Financial Contact
Company    IO Biotech
Contact person    Amy Sullivan
Function    Chief Financial Officer
   Technical Contact
Company    IO Biotech
Contact person    Mai-Britt Zocca
Function    Chief Executive Officer

The above-mentioned contact person is the responsible contact for the time being. The Borrower shall inform the Bank immediately in case of any change.

 

38


A.2.2

Information on the Investment’s implementation

The Borrower shall deliver to the Bank the following information on the Investment progress during implementation at the latest by the deadline indicated below.

 

Document / information

  

Deadlines**

  

Frequency
of reporting

Investment Progress Report, including:

 

-    A brief update on the Technical Description, explaining the reasons for significant changes vs. initial scope;

 

-    Update on the date of completion of each of the main Investment’s components, explaining reasons for any possible delay;

 

-    Update on the cost of the Investment, explaining reasons for any possible cost variations vs. initial budgeted cost;

 

-    A description of any major issue with impact on the Environment;

 

-    Update on the Investment’s demand or usage and comments;

 

-    Update on any new partnerships / collaboration agreements including any new governmental agreements;

 

-    Any significant issue that has occurred and any significant risk that may affect the Investment’s operation;

 

-    Update on any major changes in the R&D organisation with impact on the Investment’s completion;

 

-    Any legal action concerning the Investment that may be ongoing;

 

-    Non-confidential project-related pictures, if available.

  

01/09/2025*

01/09/2026**

01/09/2027***

   annual

 

*

For the period 01/09/2024 to 30/06/2025

**

For the period 01/07/2025 to 30/06/2026

***

For the period 01/07/2026 to 30/06/2027

 

A.2.3

Information on the end of the works and first year of operation

The Borrower shall deliver to the Bank the following information on the Investment completion and initial operation at the latest by the deadline indicated below.

 

Document / information

  

Date of delivery
to the Bank

Investment Completion Report, including:

 

-    A final Technical Description of the Investment as completed, explaining the reasons for any significant change compared to the Technical Description in A.1.;

 

-    Update on the overall company and any technical developments update;

 

-    The date of completion of each of the main Investment’s components, explaining reasons for any possible delay;

 

-    The final cost of the Investment, explaining reasons for any possible cost variations vs. initial budgeted cost;

 

-    Employment effects of the Investment: person-days required during implementation split by year and compared to baseline as well as permanent new jobs created;

 

-    Overview of new positions created broken down by geographical region, department (R&D, manufacturing etc.), and gender;

 

-    A description of any major issue with impact on the Environment or social impacts;

 

-    Revenues and sales generated by the Company during 2025-2027;

 

-    Number of patents filed and granted per year during 2025-2027;

 

-    Number of publications in international journals during 2025-2027;

 

-    Overview of all current partnerships / collaboration agreements including any governmental agreements;

   31/03/2028*

 

39


-    Update on the Investment’s demand or usage and comments;

 

-    Any significant issue that has occurred and any significant risk that may affect the Investment’s operation;

 

-    Any legal action concerning the project that may be on going;

 

-    Non-confidential project-related pictures, if available.

  

 

*

As of 30/09/2027

 

A.2.4

Language of reports

All reports shall be delivered in English.

 

40


Schedule B

Definition of EURIBOR

EURIBOR” means:

 

  (a)

in respect of a relevant period of less than one month, the Screen Rate (as defined below) for a term of one month;

 

  (b)

in respect of a relevant period of one or more months for which a Screen Rate is available, the applicable Screen Rate for a term for the corresponding number of months; and

 

  (c)

in respect of a relevant period of more than one month for which a Screen Rate is not available, the rate resulting from a linear interpolation by reference to two Screen Rates, one of which is applicable for a period next shorter and the other for a period next longer than the length of the relevant period,

(the period for which the rate is taken or from which the rates are interpolated being the “Representative Period”).

For the purposes of paragraphs (a) to (c) above:

 

  (i)

available” means the rates, for given maturities, that are calculated and published by Global Rate Set Systems Ltd (GRSS), or such other service provider selected by the European Money Markets Institute (EMMI), or any successor to that function of EMMI, as determined by the Bank; and

 

  (ii)

Screen Rate” means the rate of interest for deposits in EUR for the relevant period as published at 11:00 a.m., Brussels time, or at a later time acceptable to the Bank on the day (the “Reset Date”) which falls 2 (two) Relevant Business Days prior to the first day of the relevant period, on Reuters page EURIBOR 01 or its successor page or, failing which, by any other means of publication chosen for this purpose by the Bank.

If such Screen Rate is not so published, the Bank shall request the principal offices of four major banks in the euro-zone, selected by the Bank, to quote the rate at which EUR deposits in a comparable amount are offered by each of them, as at approximately 11:00 a.m., Brussels time, on the Reset Date to prime banks in the euro-zone interbank market for a period equal to the Representative Period. If at least 2 (two) quotations are provided, the rate for that Reset Date will be the arithmetic mean of the quotations. If no sufficient quotations are provided as requested, the rate for that Reset Date will be the arithmetic mean of the rates quoted by major banks in the euro-zone, selected by the Bank, at approximately 11:00 a.m., Brussels time, on the day which falls 2 (two) Relevant Business Days after the Reset Date, for loans in EUR in a comparable amount to leading European banks for a period equal to the Representative Period.

The Bank shall inform the Borrower without delay of the quotations received by the Bank.

All percentages resulting from any calculations referred to in this Schedule will be rounded, if necessary, to the nearest one thousandth of a percentage point, with halves being rounded up.

If any of the foregoing provisions becomes inconsistent with provisions adopted under the aegis of EMMI (or any successor to that function of EMMI as determined by the Bank) in respect of EURIBOR, the Bank may by notice to the Borrower amend the provision to bring it into line with such other provisions.

If the Screen Rate becomes permanently unavailable, the EURIBOR replacement rate will be the rate (inclusive of any spreads or adjustments) formally recommended by (i) the working group on euro risk-free rates established by the European Central Bank (ECB), the Financial Services and Markets Authority (FSMA), the European Securities and Markets Authority (ESMA) and the European Commission, or (ii) the European Money Market Institute, as the administrator of EURIBOR, or (iii) the competent authority responsible under Regulation (EU) 2016/1011 for supervising the European Money Market Institute, as the administrator of the EURIBOR, or (iv) the national competent authorities designated under Regulation (EU) 2016/1011, or (v) the European Central Bank.

 

41


If the Screen Rate becomes permanently unavailable and no EURIBOR replacement rate is formally recommended as provided above, EURIBOR shall be the rate (expressed as a percentage rate per annum) which is determined by the Bank to be the all-inclusive cost to the Bank for the funding of the relevant Tranche based upon the then applicable internally generated Bank reference rate or an alternative rate determination method reasonably determined by the Bank.

 

42


Schedule C

Form of Disbursement Offer/Acceptance

 

To:    IO Biotech ApS
From:    European Investment Bank
Date:    [•]
Subject:    Disbursement Offer/Acceptance for the Finance Contract between European Investment Bank and IO Biotech ApS dated 19 December 2024 (the “Finance Contract”)
   Contract Number 97869    Serapis Number 2024-0179

 

 

Dear Sirs,

We refer to the Finance Contract. Terms defined in the Finance Contract have the same meaning when used in this letter.

Following your request for a Disbursement Offer from the Bank, in accordance with Article 2.2.2 (Disbursement Offer) of the Finance Contract, we hereby offer to make available to you the following Tranche:

 

  (a)

Tranche [A/B/C]

 

  (b)

Amount to be disbursed:

 

  (c)

Disbursement Date:

 

  (d)

PIK Interest Rate:

 

  (e)

Payment Dates:

 

  (f)

Maturity Date:

 

  (g)

Number of shares of common stock of the Parent issuable pursuant to the terms of the Warrant Agreement applicable to the Tranche:

To make the Tranche available subject to the terms and conditions of the Finance Contract, the Bank must receive a Disbursement Acceptance in the form of a copy of this Disbursement Offer duly signed on your behalf, to the following electronic mail [***] no later than the Disbursement Acceptance Deadline of [time], Luxembourg time, on [date].

The Disbursement Acceptance below must be signed by an Authorised Signatory and must be fully completed as indicated, to include the details of the Disbursement Account.

If not duly accepted by the above stated time, the offer contained in this document shall be deemed to have been refused and shall automatically lapse.

If you do accept the Tranche as described in this Disbursement Offer, all the related terms and conditions of the Finance Contract shall apply, in particular, the provisions of Article 2.5 (Conditions of Disbursement).

Yours faithfully,

EUROPEAN INVESTMENT BANK

 

43


We hereby accept the above Disbursement Offer for and on behalf of the Borrower:

__________________________________________________

Date: 

Account to be credited:

Account N°:

Account Holder/Beneficiary:

(please, provide IBAN format if the country is included in IBAN Registry published by SWIFT, otherwise an appropriate format in line with the local banking practice should be provided)

Bank name, identification code (BIC) and address:

Payment details to be provided:

Please transmit information relevant to:

Name(s) of the Borrower’s Authorised Signatory(ies):

………………………………………………………..……………………………………………….. …………………..

Signature(s) of the Borrower’s Authorised Signatory(ies):

 

IMPORTANT NOTICE TO THE BORROWER:

 

BY COUNTERSIGNING ABOVE YOU CONFIRM THAT THE LIST OF AUTHORISED SIGNATORIES AND ACCOUNTS PROVIDED TO THE BANK WAS DULY UPDATED PRIOR TO THE PRESENTATION OF THE ABOVE DISBURSEMENT OFFER BY THE BANK.

 

IN THE EVENT THAT ANY SIGNATORIES OR ACCOUNTS APPEARING IN THIS DISBURSEMENT ACCEPTANCE ARE NOT INCLUDED IN THE LATEST LIST OF AUTHORISED SIGNATORIES AND ACCOUNTS RECEIVED BY THE BANK, THE ABOVE DISBURSEMENT OFFER SHALL BE DEEMED AS NOT HAVING BEEN MADE.

 

44


Schedule D

Form of Drawdown Certificate

 

To:    European Investment Bank
From:    IO Biotech ApS
Date:    [•]
Subject:    Finance Contract between European Investment Bank and IO Biotech ApS dated 19 December 2024 (the “Finance Contract”)
   Contract Number 97869    Serapis Number 2024-0179

 

Dear Sirs,

Terms defined in the Finance Contract have the same meaning when used in this letter.

For the purposes of Article 2.5 (Conditions of Disbursement) of the Finance Contract we hereby certify to you as follows:

 

  (a)

no Prepayment Event has occurred and is continuing unremedied;

 

  (b)

no Security of the type prohibited under Paragraph 23 (Negative pledge) of Schedule H (General Undertakings) has been created or is in existence;

 

  (c)

there has been no material change to any aspect of the Investment or in respect of which we are obliged to report under the Finance Contract, save as previously communicated by us;

 

  (d)

no Default, Event of Default or a Prepayment Event other than pursuant to Article 5.3.1 (Investment Cost Reduction Event) of the Finance Contract has occurred or is continuing, or would, in each case, result from the disbursement of the proposed Tranche;

 

  (e)

no litigation, arbitration administrative proceedings or investigation is current or to our knowledge is threatened or pending before any court, arbitral body or agency which has resulted or if adversely determined is reasonably likely to result in a Material Adverse Change, nor is there subsisting against us or any of our Subsidiaries any unsatisfied judgement or award;

 

  (f)

the Repeating Representations are correct in all respects;

 

  (g)

no Material Adverse Change has occurred, as compared with the situation at the date of the Finance Contract;

 

  (h)

the borrowing of the Credit, or any part thereof, by the Borrower is within the corporate powers of the Borrower; and

 

  (i)

the most recent List of Authorised Signatories and Accounts provided to the Bank by the Borrower is up-to-date and the Bank may rely on the information set out therein.

We undertake to immediately notify the Bank if any the above fails to be true or correct as of the Disbursement Date for the proposed Tranche.

Yours faithfully,

For and on behalf of IO Biotech ApS

Date:

 

45


Schedule E

Form of Compliance Certificate

 

To:    European Investment Bank
From:    IO Biotech ApS
Date:    [•]
Subject:    Finance Contract between European Investment Bank and IO Biotech ApS dated 19 December 2024 (the “Finance Contract”)
   Contract Number 97869    Serapis Number 2024-0179

 

Dear Sirs,

We refer to the Finance Contract. This is a Compliance Certificate. Terms defined in the Finance Contract have the same meaning when used in this Compliance Certificate.

We hereby confirm:

 

  (a)

that the Obligors’ revenues, assets and EBITDA continue to represent at any time 80% (eighty per cent.) of the Group’s revenues, assets and EBITDA;

 

  (b)

[insert information regarding asset disposal, if any];

 

  (c)

no Security of the type prohibited under Paragraph 23 (Negative pledge) of Schedule H (General Undertakings) has been created or is in existence; and

 

  (d)

no Default, Event of Default or a Prepayment Event other than pursuant to Article 5.3.1 (Investment Cost Reduction Event) of the Finance Contract has occurred or is continuing. [If this statement cannot be made, this certificate should identify any potential event of default that is continuing and the steps, if any, being taken to remedy it].

Yours faithfully,

For and on behalf of IO Biotech ApS

 

46


Schedule F

Initial Documentary Conditions Precedent

 

  (a)

The duly executed Finance Documents which are required by the Bank to be entered into at that time, including in particular the Finance Contract, the Warrant Issuance Agreement, the Registration Rights Agreement, the Fee Letter, the Parent Guarantee Agreement, a Guarantee Agreement duly executed by IOB US and any other Guarantee Agreement required to be entered into pursuant to this Contract.

 

  (b)

The constitutional documents of each Obligor.

 

  (c)

A copy of the resolution of the competent body (board of directors, management board, supervisory board or general meeting of shareholders) of each Obligor duly authorising the execution of the Finance Documents to which it is a party and duly authorising the relevant signatories (to the extent required by law or constitutional documents of each Obligor).

 

  (d)

The List of Authorised Signatories and Accounts.

 

  (e)

A copy of any power of attorney authorising the signatories to sign the relevant Finance Documents (if any).

 

  (f)

Legal opinion as to the matters of Danish law, in the English language, issued by an external legal counsel of the Bank, amongst others, on the legality, validity and enforceability of the Finance Documents.

 

  (g)

Legal opinion(s), in the English language, issued by external legal adviser(s) to the Borrower, addressed to the Bank on the due incorporation, valid existence and registration of the Borrower, the authority and capacity of the Borrower to enter into the Finance Documents and perform its obligations thereunder, non-conflict with constitutional documents and on any existing Danish laws applicable to companies generally that would render the opinion documents invalid, no consents, registrations or filings are required and no stamp duty is to be paid in respect of the Finance Documents, all corporate and other action required to be taken has indeed been taken, the due execution of the Finance Documents, choice of law and enforceability of judgments and that the Borrower is not entitled to claim immunity.

 

  (h)

Legal opinion, in the English language, issued by external legal adviser(s) to the Parent, addressed to the Bank:

 

  (i)

that the Parent and IOB US is each a corporation duly organised and validly existing in good standing and has the requisite corporate power and authority to (A) enter into the relevant Finance Documents and (B) perform its obligations under such Finance Documents;

 

  (ii)

that the Parent and IOB US has each duly authorised, entered into, executed, and delivered the relevant Finance Documents, and such Finance Documents constitute its valid and binding obligations enforceable against it in accordance with their terms;

 

  (iii)

on non-conflict with organisational documents or applicable laws;

 

  (iv)

that no consents, registrations, or filings are required under US federal law in respect of the relevant Finance Documents;

 

  (v)

that the warrants set forth in the Warrant Agreements, when issued in accordance with the terms of the Warrant Issuance Agreement, shall be duly authorised and validly issued by the Parent and constitute a legal, valid, and binding obligation enforceable against it in accordance with its terms;

 

  (vi)

that all shares issued upon exercise of the warrants set forth in the Warrant Agreements shall be duly authorised and validly issued, fully paid, and non-assessable and shall not have been issued in violation of any pre-emptive or other similar rights; and

 

47


  (vii)

that no stamp, registration, documentary, or similar tax levied by the United States is required to be paid in connection with the execution, delivery, or enforcement of the relevant Finance Documents.

 

  (i)

A structure chart showing the Group certified as being complete and correct by an Authorised Signatory(ies) of the Borrower provided such certification is dated no earlier than the date falling 14 (fourteen) Business Days before the Disbursement Date.

 

  (j)

The latest audited financial statements of the Obligors.

 

  (k)

Evidence of payment of all the fees and expenses as required under the Finance Documents.

 

  (l)

A certificate of an authorised signatory of each Obligor certifying that each copy document relating to it specified in Schedule F (Initial Documentary Conditions Precedent) is correct, complete and in full force and effect as at a date no earlier than the date falling 14 (fourteen) Business Days before the Disbursement Date.

 

  (m)

A copy of any other document, authorisation, opinion or assurance which the Bank has notified the Borrower is necessary or desirable in connection with the entry into and performance of, and the transactions contemplated by, the Finance Documents or the validity and enforceability of the same.

 

48


Schedule G

Representations and Warranties

 

  1.

Authorisations and Binding Obligations

 

  (a)

Each Obligor is duly incorporated and validly existing as a company with limited liability under the laws of its jurisdiction of incorporation. No Obligor’s shares are publicly traded with the exception of the shares of the Parent.

 

  (b)

Each Obligor has the power to carry on its business as it is now being conducted and to own its property and other assets, and to execute, deliver and perform its obligations under the Finance Documents.

 

  (c)

Each Obligor has obtained all necessary Authorisations in connection with the execution, delivery and performance of the Finance Documents and in order to lawfully comply with its obligations thereunder, and in respect of the Investment, and all such Authorisations are in full force and effect and admissible in evidence.

 

  (d)

The execution and delivery of, the performance of each Obligor’s obligations under and compliance with the provisions of the Finance Documents do not and will not contravene or conflict with:

 

  (i)

subject to the Legal Reservations, any applicable law, statute, rule or regulation, or any judgement, decree or permit to which it is subject;

 

  (ii)

any agreement or other instrument binding upon it which might reasonably be expected to have a material adverse effect on its ability to perform its obligations under the Finance Documents; or

 

  (iii)

any provision of its constitutional documents.

 

  (e)

The obligations expressed to be assumed by each Obligor in each Finance Document to which it is a party are, subject to the Legal Reservations, legal, valid, binding and enforceable obligations.

 

  2.

Eligible Territory

The Borrower is established in an Eligible Territory.

 

  3.

No default or other adverse event

 

  (a)

There has been no Material Adverse Change since 17 December 2024. (Non-repeating)

 

  (b)

No event or circumstance which constitutes an Event of Default has occurred and is continuing unremedied or unwaived.

 

  4.

No proceedings

 

  (a)

No litigation, arbitration, administrative proceedings or investigation is current or to its knowledge is threatened or pending before any court, arbitral body or agency which has resulted or if adversely determined is reasonably likely to result in a Material Adverse Change, nor is there subsisting against it or any of its Subsidiaries any unsatisfied judgement or award.

 

  (b)

To the best of its knowledge and belief (having made due and careful enquiry) no material Environmental or Social Claim has been commenced or is threatened against any Obligor or any relevant Affiliate in relation to the Investment.

 

  (c)

As at the date of this Contract, no Obligor has taken any action to commence proceedings for, nor have any other steps been taken or legal proceedings commenced or, so far as the Borrower is aware, threatened against any Obligor for its insolvency, winding up or dissolution, or for any Obligor to enter into any arrangement or compositions for the benefit of creditors, or for the appointment of an administrator, receiver, administrative receiver, examiner, trustee or similar officer. (Non-repeating)

 

49


  5.

Security

At the date of this Contract, no Security exists over the assets of any Group Company other than Permitted Security. (Non-repeating)

 

  6.

Ranking

 

  (a)

Its payment obligations under this Contract rank not less than pari passu in right of payment with all other present and future unsecured and unsubordinated obligations under any of its debt instruments except for obligations mandatorily preferred by law applying to companies generally.

 

  (b)

No financial covenants have been concluded with any other creditor of any Obligor. (Non-repeating)

 

  (c)

No Voluntary Non-EIB Prepayment Event has occurred. (Non-repeating)

 

  7.

Anti-Corruption

 

  (a)

Each Obligor is in compliance with all applicable European Union and national legislation regarding Illegal Activities.

 

  (b)

No Obligor is engaged in any Illegal Activities and to the best of the Borrower’s knowledge no Illegal Activities have occurred in connection with the Loan and the Investment. (Non-repeating)

 

  8.

Accounting and Tax

 

  (a)

The latest available consolidated and unconsolidated audited accounts of the Borrower and the other Obligors have been prepared on a basis consistent with previous years and have been approved by its auditors and fairly presents, in all material respects, the financial condition and result of operations of the Borrower and the other Obligors, as relevant.

 

  (b)

The accounting reference date of the Borrower is 31st December.

 

  (c)

No Obligor is required to make any deduction for or on account of any Tax from any payment it may make under the Finance Documents. (Non-repeating)

 

  (d)

All Tax returns required to have been filed by each Obligor or on its behalf under any applicable law have been filed when due and contain the information required by applicable law to be contained in them.

 

  (e)

Each Obligor has paid when due all Taxes payable by it under applicable law except to the extent that it is contesting payment in good faith and by appropriate means.

 

  (f)

With respect to Taxes which have not fallen due or which it is contesting, each Obligor is maintaining reserves adequate for their payment and in accordance, where applicable, with GAAP.

 

  (g)

Under the laws of the jurisdiction of incorporation of each Obligor, it is not necessary that the Finance Documents be filed, recorded or enrolled with any court or other authority or that any stamp, registration or similar tax be paid on or in relation to the Finance Documents, or the transactions contemplated by the Finance Documents. (Non-repeating)

 

  (h)

No Obligor is a FATCA FFI.

 

  9.

Information provided

 

  (a)

Any information provided by any Group Company for the purposes of entering into this Contract and any related documentation was true and accurate in all material respects as at the date it was provided or as at the date (if any) at which it is stated and continues to be true and accurate in all material respect as at the date of this Contract;

 

50


  (b)

The Group structure chart is true, complete and accurate in all material respects and represents the complete corporate structure of the Group as at the date of this Contract, and other than as set out therein the Borrower owns no other equity and/or shares in any other business entity. (Non-repeating);

 

  (c)

As at the date of this Contract:

 

  (i)

the information provided by the Borrower under the Declaration of Honour and InvestEU Fund MSS Declaration is complete, accurate and true in all respects; and

 

  (ii)

the Borrower (and the Group as a whole where relevant) complies with the eligibility and exclusion criteria to be the beneficiary of the Credit as such criteria are listed in the Declaration of Honour and InvestEU Fund MSS Declaration. (Non-repeating)

 

  10.

No indebtedness

No Obligor has Indebtedness outstanding other than Permitted Indebtedness. (Non-repeating).

 

  11.

No Immunity

No Obligor, nor any of its assets, is entitled to immunity from suit, execution, attachment or other legal process.

 

  12.

Pensions

The pension schemes for the time being operated by the Obligors (if any) are funded in accordance with their rules and to the extent required by law or otherwise comply with the requirements of any law applicable in the jurisdiction in which the relevant pension scheme is maintained.

 

  13.

Sanctions

No Obligor and/or any Relevant Person

 

  (a)

is a Sanctioned Person; or

 

  (b)

is in breach of any Sanctions.

It is acknowledged and agreed that the representations set out in this Paragraph 13 (Sanctions) are only sought by and given to the Bank to the extent that to do so would be permissible pursuant to any applicable anti-boycott rule of the EU such as Regulation (EC) 2271/96.

 

51


Schedule H

General Undertakings

 

  1.

Use of Loan

The Borrower shall use all amounts borrowed by it under the Loan exclusively to carry out the Investment. In any event, the Borrower shall ensure that the amount of the Credit together with any principal loan amount provided by another implementing partner under the InvestEU Fund shall not exceed 50% (fifty per cent.) of the total cost of the Investment set out in Recital (A).

 

  2.

Completion of Investment

The Borrower shall or shall procure that the Investment is carried out in accordance with the Technical Description as may be modified from time to time with the approval of the Bank, and complete it by the final date specified therein.

 

  3.

Procurement procedure

 

  (a)

The Borrower shall procure works, goods and services for the Investment:

 

  (i)

in accordance with EU Law in general and in particular with the relevant European Union procurement directives, if the latter are applicable;

 

  (ii)

in accordance with procurement procedures which, to the satisfaction of the Bank (acting reasonably), respect the criteria of economy and efficiency and the principles of transparency, equal treatment and non-discrimination on the basis of nationality in case of public contracts not subject to the European Union procurement directives; or

 

  (iii)

in accordance with procurement procedures which, to the satisfaction of the Bank (acting reasonably), respect the criteria of economy and efficiency in case of contracts other than public contracts not subject to the European Union procurement directives.

 

  (b)

For cases (i) and (ii) of paragraph (a) above, the Borrower shall request in the tender documents or other reference documents for the procurement procedures referred to in sub-paragraph (a) above that the bidder declares whether or not it is subject to any exclusion decision or temporary suspension pursuant to the Exclusion Policy.

 

  (c)

If a bidder declares to the Borrower prior to the contract award that it is subject to any exclusion decision or temporary suspension covered by the Exclusion Policy, the Borrower shall engage with the Bank in good faith and shall make best efforts in order to:

 

  (i)

achieve an exclusion of such a bidder under applicable law so that the bidder does not participate in the Investment or, should such an exclusion not be possible,

 

  (ii)

restructure the scope of the Investment so that no proceeds of the Loan be applied towards any works or services under any contract awarded to that bidder, unless otherwise agreed with the Bank.

 

  4.

Compliance with laws

 

  (a)

Each Obligor shall comply in all respects with all laws to which it or the Investment is subject, if failure so to comply would materially impair the ability of any Obligor to perform its obligations under any Finance Document.

 

  (b)

Notwithstanding paragraph (a) above, each Obligor shall comply in all respects with any laws to which it may be subject and the breach of which would constitute an Illegal Activity.

 

52


  5.

Environment and Social Matters

The Borrower shall:

 

  (a)

implement and operate the Investment materially in compliance with Environmental and Social Law;

 

  (b)

obtain and maintain requisite Environmental and Social Approvals for the Investment; and

 

  (c)

materially comply with any such Environmental and Social Approvals;.

and upon becoming aware of any breach of this Paragraph 5 (Environment and Social Matters):

 

  (d)

the Borrower shall promptly notify the Bank;

 

  (e)

the Borrower and the Bank will consult for up to 15 (fifteen) Business Days from the date of notification with a view to agreeing the manner in which the breach should be rectified; and

 

  (f)

the Borrower shall remedy the breach within 30 (thirty) Business Days of the end of the consultation period.

 

  6.

Integrity

The Borrower shall not engage in (and shall not authorise or permit any person acting on its behalf or under its control to engage in) any conduct of Illegal Activity in connection with the Loan and the Investment.

 

  7.

Disposal of assets

 

  (a)

Except as provided below, the Borrower shall not, and shall procure that no Group Company shall, either in a single transaction or in a series of transactions whether related or not and whether voluntarily or involuntarily dispose of all or any part of any Group Company’s business, undertaking or assets (including any shares or security of any entity or a business or undertaking, or any interest in any of them).

 

  (b)

Sub-paragraph (a) above does not apply to any such disposal:

 

  (i)

made with the prior written consent of the Bank;

 

  (ii)

made on arm’s length terms in the ordinary course of business of a Group Company (including, for the avoidance of doubt, any partnership and similar agreements);

 

  (iii)

made on arm’s length terms and at fair market value for cash, which is reinvested in assets of comparable or superior type, value and quality;

 

  (iv)

made on arm’s length terms in exchange for other assets comparable or superior as to type, value and quality;

 

  (v)

made by one Obligor to another Obligor;

 

  (vi)

made by a Group Company which is not an Obligor to another Group Company;

 

  (vii)

constituted by a licence of Intellectual Property Rights made on arm’s length terms;

 

  (viii)

made in relation to non-material assets which have depreciated to less than 25% (twenty five per cent.) of their initial value or which are obsolete;

 

  (ix)

disposals made in relation to non-core assets on arm’s length terms (including disposals of IO112 or IO170);

 

  (x)

made on arm’s length terms and consisting of a conveyance to a third party of a right to receive royalties on future sales pursuant to a Royalty Agreement as set out in sub-paragraph (g) of Paragraph 15 (Indebtedness);

 

53


  (xi)

excluding any disposal otherwise permitted under sub-paragraphs (ii) to (x) above, disposals where the higher of the market value or consideration receivable for such disposals does not exceed (x) 10% (ten per cent.) of Total Assets during any financial year, and (y) 25% (twenty five per cent.) of Total Assets during the term of the Credit; or

 

  (xii)

arising as a result of Permitted Security,

provided that, in respect of sub-paragraphs (ii) to (iv), (viii), (ix) and (xi) to (xii) above (unless otherwise agreed between the Parties), the disposal is not of assets forming part of the Investment or shares in subsidiaries holding assets forming part of the Investment, which may not be disposed of unless either (a) the Borrower consults the Bank in relation to such disposal, and the Bank approves the disposal, or (b) the proceeds of the disposal are applied to prepay the Bank in accordance with Article 5.3.5 (Disposals),

and further provided that any disposal on arm’s length terms of IO112 or IO170 completed before the relevant asset enters phase II development shall not require prepayment pursuant to Article 5.3.5 (Disposals).

For the purposes of this Paragraph 7 (Disposal of assets), “dispose” and “disposal” includes any act effecting sale, transfer, lease or other disposal.

 

  8.

Maintenance of assets

The Borrower shall maintain, repair, overhaul and renew all assets required in relation to the Investment as required to keep such assets in good working order.

 

  9.

Insurances

The Borrower shall, and shall procure that each Group Company shall, maintain insurances on and in relation to its business and assets with reputable underwriters or insurance companies against those risks and to the extent as is usual for companies carrying on the same or substantially similar business.

 

  10.

Change in business

The Borrower shall procure that no substantial change is made to the general nature business of the Borrower or the Group as a whole from that carried on at the date of this Contract.

 

  11.

Merger

The Borrower shall not, and shall procure that no Group Company shall, enter into any amalgamation, demerger, merger or corporate reconstruction unless:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

that merger implements an acquisition permitted under Paragraph 14 (Acquisitions) below, provided that a Group Company (and if the Borrower is part of that merger, the Borrower) is the continuing entity; or

 

  (c)

such amalgamation, demerger, merger or corporate reconstruction does not result in a Material Adverse Change and is on a solvent basis, and provided that:

 

  (i)

only Group Companies are involved;

 

  (ii)

the resulting entity will not be incorporated or located in a country which is in a jurisdiction that is blacklisted by any Lead Organisation in connection with activities such as money laundering, financing of terrorism, tax fraud and tax evasion or harmful tax practices as such blacklist may be amended from time to time; and

 

54


  (iii)

if the Borrower is involved, (1) the rights and obligations of the Borrower under this Contract will remain with the Borrower, (2) the surviving entity will be the Borrower and the statutory seat of the Borrower would not as a result of such merger be transferred to a different jurisdiction, (3) the merger will not have an adverse effect on the validity, legality or enforceability of the Borrower’s obligations under this Contract or any other Finance Document; and (4) all of the business and assets of the Borrower are retained by it.

 

  12.

Books and records

Each Obligor shall ensure that it has kept and will continue to keep proper books and records of account, in which full and correct entries shall be made of all financial transactions and its assets and business, including expenditures in connection with the Investment, in accordance with GAAP as in effect from time to time.

 

  13.

Ownership

 

  (a)

The Borrower shall, and shall procure that the Parent will, maintain more than 50% (fifty per cent.) of the share capital, directly or indirectly, of each of its Material Subsidiaries, unless a prior written consent of the Bank is received by the Borrower.

 

  (b)

The Borrower shall, and shall procure that the Parent will, in aggregate maintain more than 50% (fifty per cent.) of the share capital, directly or indirectly, of each Guarantor (other than the Parent), unless prior written consent of the Bank is received by the Borrower.

 

  (c)

The Borrower shall ensure that the Parent directly maintains 100% (one hundred per cent.) of the share capital of the Borrower, unless a prior written consent of the Bank is received by the Borrower.

 

  (d)

The Borrower shall immediately notify the Bank in the event of a new entity becoming a Subsidiary through any means, including but not limited to acquisition, creation and spin-off.

 

  (e)

The undertakings in sub-paragraphs (a), (b) and (c) above shall be calculated in accordance with GAAP as applied by the Borrower on the date of this Contract and as GAAP is amended from time to time and tested annually.

 

  14.

Acquisitions

The Borrower shall not, and shall procure that no Group Company shall, invest in or acquire any entity or a business going concern or an undertaking (whether whole or substantially the whole of the assets or business), or any division or operating unit thereof, or any shares or securities of any entity or a business or undertaking (or in each case, any interest in any of them) (or agree to any of the foregoing), save for an acquisition or investment:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

made by a Group Company as part of treasury transactions;

 

  (c)

of assets pursuant to disposals permitted pursuant to sub-paragraphs (b)(v) and (b)(vi) of Paragraph 7 (Disposal of assets) above;

 

  (d)

consisting of the formation of a new company or the acquisition of an off-the-shelf company (i.e. an existing, registered, but not operating company), provided that;

 

  (i)

such entity has not yet commenced commercial operations, has no liabilities and has not generated any loss from any activity;

 

  (ii)

such entity is incorporated in a country that is a member of either or both of the European Union or the Organisation of Economic Co-Operation and Development; and

 

  (iii)

no Event of Default is continuing on the date the relevant acquisition agreement is entered into or would occur as a result of the acquisition;

 

55


  (e)

by a Group Company of all the shares or other ownership interests in any limited liability company or corporation, limited liability partnership or any equivalent company, provided that:

 

  (i)

such entity has commenced commercial operations;

 

  (ii)

such entity is incorporated in a country that is a member of either or both of the European Union or the Organisation of Economic Co-Operation and Development; and

 

  (iii)

no Event of Default is continuing on the date the relevant acquisition agreement is entered into or would occur as a result of the acquisition;

 

  (f)

of shares or other ownership interest in any limited liability company or corporation, provided that such acquisition is directly or indirectly funded by way of equity into the Parent or shareholder loans to the Parent subordinated to the satisfaction of the Bank; and

 

  (g)

of shares or other ownership interests in any limited liability company or corporation, limited liability partnership or any equivalent company or of the whole or substantially the whole of the assets or business of such entity or of any division or operating unit thereof, the consideration for which is paid in shares or does not exceed an amount in aggregate for the Group equal to 5% of Total Assets at the date of the acquisition, provided that:

 

  (i)

no Event of Default is continuing on the date the relevant acquisition agreement is entered into or would occur as a result of the acquisition;

 

  (ii)

the acquired entity is engaged in a business similar or complementary to the business carried on by the Group as at the date of this Contract;

 

  (iii)

the acquired entity is not incorporated or located in a jurisdiction that is blacklisted by any Lead Organisation in connection with activities such as money laundering, financing of terrorism, tax fraud and tax evasion or harmful tax practices as such blacklist may be amended from time to time;

 

  (iv)

in respect of any acquisition where the consideration exceeds EUR 10,000,000 (ten million euro) (or its equivalent in another currency or currencies), legal and financial due diligence reports (including customary reliance letters in favour of the Bank) and a business plan (in the form of the most recent budget adjusted for the expected effects of the acquisition) in respect of the 3 (three) next following financial years and any other due diligence reports received in connection with the acquisition (if any) are provided to the Bank; and

 

  (v)

the Borrower provides a Compliance Certificate for the 2 (two) 12 (twelve) month financial periods immediately following the acquisition, updated on a pro forma basis as if the acquisition has occurred.

 

  15.

Indebtedness

The Borrower shall not, and shall procure that no other Group Company shall, incur any Indebtedness, save for Indebtedness incurred:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

under this Contract;

 

  (c)

under any loan permitted pursuant to Paragraph 19 (Restrictions on loans) below;

 

  (d)

in the ordinary course of business with trade suppliers or customers;

 

  (e)

in the ordinary course of business under an agreement to pay discounts, rebates or chargebacks on a Group Company’s product;

 

  (f)

and which is subordinated to the Credit on terms satisfactory to the Bank;

 

56


  (g)

under a royalty deal agreement (a “Royalty Agreement”) under which the Borrower may receive one or several lump sum payment(s) in consideration for a percentage of the future sales of a product, provided that the annual aggregate amount to be paid by the Borrower under the Royalty Agreement does not exceed an amount equal to 10% (ten per cent.) of the annual net sales of the product as defined and determined in such Royalty Agreement;

 

  (h)

under any convertible loans and/or convertible loan notes issued by the Parent, provided that:

 

  (i)

no payments of interest or repayments or prepayments of principal are scheduled or made prior to the latest Maturity Date; and

 

  (ii)

either:

 

  (1)

the Indebtedness thereunder and the relevant creditor’s rights are subordinated to the Credit on terms acceptable to the Bank; or

 

  (2)

all Indebtedness thereunder automatically converts into common equity of the Parent immediately upon the occurrence of the Parent’s insolvency;

 

  (i)

under any Finance Lease if the aggregate liability in respect of the equipment leased under all Finance Leases does not at any time exceed an amount equal to 10% of Fixed Assets;

 

  (j)

under any factoring arrangement, provided that the aggregate face value of outstanding receivables subject to such arrangement does not at any time exceed an amount equal to 10% of Trade Receivables;

 

  (k)

under Permitted Hedging;

 

  (l)

under any letters of credit provided that such Indebtedness does not, singularly or in aggregate, exceed an amount equal to 10% of Trade Payables;

 

  (m)

in respect of a Permitted Guarantee; or

 

  (n)

not permitted by the preceding sub-paragraphs and the outstanding amount of which, when aggregated with the amount of all Indebtedness permitted pursuant to sub-paragraphs (i), (j), (l) or (m) above, does not exceed an amount in aggregate for the Group at any time equal to 10% (ten per cent.) of Total Assets.

 

  16.

Guarantees

 

  (a)

The Borrower shall not, and shall procure that no other Group Company shall, issue or allow to remain outstanding any guarantees in respect of any liability or obligation of any person save for:

 

  (i)

with the prior written consent of the Bank; or

 

  (ii)

guarantees issued in the ordinary course of trade by any Group Company:

 

  (1)

under any Guarantee Agreement;

 

  (2)

under any negotiable instruments;

 

  (3)

in connection with any performance bond; or

 

  (4)

in connection with any Permitted Indebtedness;

 

  (iii)

guarantees issued by one Obligor for the obligations of another Obligor;

 

  (iv)

guarantees issued by a Group Company which is not an Obligor for the obligations of another Group Company;

 

  (v)

customary guarantee and indemnity obligations in connection with any disposal permitted pursuant to Paragraph 7 (Disposal of assets) above, provided that the Group’s liability under any such guarantee and indemnity obligation does not exceed an amount equal to the cash consideration received by the Group in connection with that disposal; and

 

57


  (vi)

any other guarantees the aggregate liabilities of which do not at any time exceed an amount equal to 5% of Total Assets.

 

  (b)

The Borrower shall procure that, as soon as any Group Company becomes a Material Subsidiary (as identified in any accounts delivered to the Bank from time to time pursuant to Paragraph 2 (Information concerning the Borrower) of Schedule I (Information and Visits)), that Group Company shall promptly notify the Bank and promptly, but not later than within 60 (sixty) days of the Bank’s request, enter into a Guarantee Agreement and provide the Bank with:

 

  (i)

a certified copy of the resolution of the competent body (management board, supervisory board, board of directors and/or general meeting of shareholders) of such Material Subsidiary duly authorising the execution of such Guarantee Agreement and duly authorising the person or persons signing such Guarantee Agreement on behalf of such Material Subsidiary together with the specimen signature of each such person or persons;

 

  (ii)

evidence that such Material Subsidiary has obtained all necessary Authorisations required in connection with such Guarantee Agreement and, where applicable, any accession deed in respect of such Guarantee Agreement;

 

  (iii)

a legal opinion of a reputable law firm in the jurisdiction of incorporation of such Material Subsidiary, addressed to the Bank on the valid existence of such Material Subsidiary, the authority and capacity of such Material Subsidiary to enter into the Guarantee Agreement and on the due execution and choice of law of the Guarantee Agreement; and

 

  (iv)

evidence of the solvency position of the Material Subsidiary in the form of a solvency certificate in which the Material Subsidiary makes a representation about its solvency and (if available in a given jurisdiction) attaches to it relevant evidence of such solvency status from competent public registers,

each in form and substance satisfactory to the Bank.

 

  17.

Hedging

The Borrower shall not, and shall procure that no other Group Company shall, enter into any derivative transaction other than Permitted Hedging, where “Permitted Hedging” means:

 

  (a)

any derivative transaction by a Group Company to hedge actual or projected exposure arising in the ordinary course of trading and not for speculative purposes; and

 

  (b)

any derivative instrument of a Group Company which is accounted for on a hedge accounting basis but is not entered into for speculative purposes.

 

  18.

Restrictions on distributions

The Parent shall not declare or distribute dividends, or return or purchase shares, save for with the prior written consent of the Bank.

 

  19.

Restrictions on loans

The Borrower shall not, and shall ensure that no other Group Company will, be a creditor in respect of any Indebtedness, save for:

 

  (a)

any trade credit extended by any Group Company to its customers on normal commercial terms and in the ordinary course of its trading activities;

 

  (b)

(subject to compliance with Paragraph 20 (Restrictions on Intercompany Loans) below) loans by an Obligor to another Obligor;

 

58


  (c)

(subject to compliance with Paragraph 20 (Restrictions on Intercompany Loans) below) any loan made by a Group Company (other than an Obligor) to another Group Company;

 

  (d)

(subject to compliance with Paragraph 20 (Restrictions on Intercompany Loans) below) loans by an Obligor to a Group Company which is not an Obligor provided that the aggregate outstanding amount of such loans does not exceed an amount equal to the higher of USD 1,000,000 (one million United States dollars) (or its equivalent in another currency or currencies) and 1% of Total Assets;

 

  (e)

any other loans not exceeding in aggregate a principal amount of USD 100,000 (one hundred thousand United States dollars) (or its equivalent in another currency or currencies); or

 

  (f)

any other Indebtedness or loan advanced to or made available by any Group Company with the prior written consent of the Bank.

 

  20.

Restrictions on Intercompany Loans

The Borrower shall not, and shall procure that no other Group Company shall, make any payment in respect of any Intercompany Loan, save for:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

where the creditor of the Intercompany Loan is an Obligor; or

 

  (c)

payments to a Group Company as a result of a solvent liquidation or reorganisation of a Group Company which is not an Obligor.

 

  21.

Intellectual Property Rights

The Borrower shall, and shall procure that each other Group Company shall:

 

  (a)

obtain, safeguard and maintain its rights with respect to the Intellectual Property Rights required for the implementation of the Investment in accordance with this Contract, including complying with all material contractual provisions and that the implementation of the Investment in accordance with this Contract will not result in the infringement of the rights of any person with regard to the Intellectual Property Rights; and

 

  (b)

ensure that any Intellectual Property Rights required for the implementation of the Investment will be owned by or licensed to the Borrower and/or other Group Companies, and where such Intellectual Property Rights which are owned by a Group Company are capable of registration, are registered to such party.

 

  22.

Maintenance of Status

The Borrower shall, and shall procure that each other Group Company shall, remain duly incorporated and validly existing as a corporate entity with limited liability under the jurisdiction in which it is incorporated and that it will have no centre of main interests, permanent establishment or place of business outside the jurisdiction in which it is incorporated, and that it will continue to have the power to carry on its business as it is now being conducted and continue to own its property and other assets.

 

  23.

Negative pledge

 

  (a)

The Borrower shall not (and shall procure that no other Group Company shall) create or permit to subsist any Security over any of its assets.

 

59


  (b)

For the purposes of this Paragraph 23 (Negative pledge), the term Security shall also include any arrangement or transaction on assets or receivables or money (such as the sale, transfer or other disposal of assets on terms whereby they are or may be leased to or re-acquired by any Group Company, the sale, transfer or other disposal of any receivables on recourse terms or any arrangement under which money or the benefit of a bank account or other account may be applied or set off or any preferential arrangement having a similar effect) in circumstances where the arrangement or transaction is entered into primarily as a method of raising credit or of financing the acquisition of an asset.

 

  (c)

Sub-paragraph (a) above does not apply to any Security, listed below:

 

  (i)

any netting or set-off arrangement entered into by any Group Company in the ordinary course of its banking arrangements for the purpose of netting debit and credit balances;

 

  (ii)

any payment or close out netting or set-off arrangement pursuant to any Permitted Hedging, but excluding any Security under a credit support arrangement in relation to a hedging transaction;

 

  (iii)

any lien arising by operation of law and in the ordinary course of trading;

 

  (iv)

any Security over or affecting any asset acquired by Group Company after the date of this Contract if:

 

  (1)

the Security was not created in contemplation of the acquisition of that asset by a Group Company;

 

  (2)

the principal amount secured has not been increased in contemplation of or since the acquisition of that asset by a Group Company; and

 

  (3)

the Security is removed or discharged within 3 (three) months of the date of acquisition of such asset;

 

  (v)

any Security over or affecting any asset of any company which becomes a Group Company after the date of this Contract, where the Security is created prior to the date on which that company becomes a Group Company, if:

 

  (1)

the Security was not created in contemplation of the acquisition of that company;

 

  (2)

the principal amount secured has not increased in contemplation of or since the acquisition of that company; and

 

  (3)

the Security is removed or discharged within 3 (three) months of that company becoming a Group Company;

 

  (vi)

any Security arising under any retention of title, hire purchase or conditional sale arrangement or arrangements having similar effect in respect of goods supplied to a Group Company in the ordinary course of trading and on the supplier’s standard or usual terms and not arising as a result of any default or omission by any Group Company; or

 

  (vii)

any Security securing indebtedness the principal amount of which (when aggregated with the principal amount of any other indebtedness which has the benefit of Security given by a Group Company other than any permitted under sub-paragraphs (i) to (vi) above) does not exceed USD 1,000,000 (one million United States dollars) (or its equivalent in another currency or currencies).

 

  24.

Other Undertakings

The Borrower shall take note of the Bank’s group statement on tax fraud, tax evasion, tax avoidance, aggressive tax planning, money laundering and financing of terrorism (as published on the Bank’s website and as may be amended from time to time).

 

60


  25.

Data Protection

 

  (a)

When disclosing information (other than mere contact information relating to the Borrower’s personnel involved in the management of this Contract (“Contact Data”)) to the Bank in connection with this Contract, the Borrower shall redact or otherwise amend that information (as necessary) so that it does not contain any personal data, except where this Contract specifically requires, or the Bank specifically in writing requests, the disclosure of that information in the form of personal data.

 

  (b)

Before disclosing any personal data (other than Contact Data) to the Bank in connection with this Contract, the Borrower shall ensure that each data subject of those personal data:

 

  (i)

has been informed of the disclosure (including the categories of personal data to be disclosed); and

 

  (ii)

has the information in (or has been provided with an appropriate link to) the Bank’s privacy statement in relation to its lending and investment activities set out at the relevant time at https://www.eib.org/en/privacy/lending (or such other address as the Bank may notify to the Borrower in writing from time to time).

 

  26.

Sanctions

The Borrower shall not, and shall procure that no Obligor shall, directly or indirectly:

 

  (a)

enter into a business relationship with, and/or make any funds and/or economic resources available to, or for the benefit of, any Sanctioned Person in connection with the Investment; or

 

  (b)

use all or part of the proceeds of the Loan or lend, contribute or otherwise make available such proceeds to any person in any manner that would result in a breach by itself and/or by the Bank of any Sanctions; or

 

  (c)

fund all or part of any payment under this Contract or any Guarantee Agreement out of proceeds derived from activities or businesses with a Sanctioned Person, a person in breach of the Sanctions or in any manner that would result in a breach by itself and/or by the Bank of any Sanctions.

It is acknowledged and agreed that the undertakings set out in this Paragraph 26 (Sanctions) are only sought by and given to the Bank to the extent that to do so would be permissible pursuant to any applicable anti-boycott rule of the EU such as Regulation (EC) 2271/96.

 

  27.

Repayment of Loan under the InvestEU Fund

The Borrower shall ensure that the moneys to repay any Tranche under this Contract do not come from grants under an EU program.

 

  28.

Clauses by inclusion

If the Borrower or any Group Company concludes with any other unsecured and unsubordinated creditor a financing agreement having a term of more than one year that includes a loss-of-rating clause or a covenant or other provision regarding its financial ratios, if applicable, that is not provided for in this Contract or is more favourable to the relevant creditor than any equivalent provision of this Contract is to the Bank, the Borrower shall promptly inform the Bank and shall provide a copy of the more favourable provision to the Bank. The Bank may request that the Borrower promptly executes an agreement to amend this Contract so as to provide for an equivalent provision in favour of the Bank.

 

  29.

Obligors’ revenues, assets and EBITDA threshold

The Borrower shall, and shall procure that any other Obligor will, ensure that the Obligors’ revenues, assets and EBITDA represent at any time 80% (eighty per cent.) of the Group’s revenues, assets and EBITDA.

 

61


  30.

Ranking

The Borrower must ensure that its payment obligations under this Contract rank not less than pari passu in right of payment with all other present and future unsecured and unsubordinated obligations under any of its debt instruments except for obligations mandatorily preferred by law applying to companies generally.

 

  31.

Shareholders’ agreement

The Borrower shall not (and shall ensure that no shareholder of the Borrower will with respect to the Borrower’s shares) enter into any shareholder agreement or any other documents of similar nature without the prior written consent of the Bank.

 

62


Schedule I

Information and Visits

 

  1.

Information concerning the Investment

 

  (a)

The Borrower shall deliver to the Bank:

 

  (i)

the information in content and in form, and at the times, specified in Part A.2 (Information Duties) of Schedule A (Investment Specification and Reporting) or otherwise as agreed from time to time by the Parties to this Contract;

 

  (ii)

any such information or further document concerning the Investment as the Bank may require to comply with its obligations under the InvestEU Regulation; and

 

  (iii)

any such information or further document concerning the financing, procurement, implementation, operation and environmental or social matters of or for the Investment as the Bank may reasonably require within a reasonable time,

provided always that if such information or document is not delivered to the Bank on time, and the Borrower does not rectify the omission within a reasonable time set by the Bank in writing, the Bank may remedy the deficiency, to the extent feasible, by employing its own staff or a consultant or any other third party, at the Borrower’s expense and the Borrower shall provide such persons with all assistance necessary for the purpose.

 

  (b)

The Borrower shall submit for the approval of the Bank without delay any fundamental changes to the technical description of the Investment as set out in Part A.1 of Schedule A (Investment Specification and Reporting).

 

  (c)

The Borrower shall promptly inform the Bank of:

 

  (i)

any action initiated or any objection raised by any third party or any genuine complaint received by the Borrower, which is material, or any Environmental or Social Claim that is to its knowledge commenced, pending or threatened against it with regard to environmental or other matters affecting the Investment;

 

  (ii)

any fact or event known to the Borrower, which may substantially prejudice or affect the Borrower’s ability to execute the Investment;

 

  (iii)

any incident or accident relating to the Investment which has or is likely to have a significant adverse effect on the Environment or on Social Matters;

 

  (iv)

a genuine allegation, complaint or information with regard to Illegal Activities or any Sanctions related to the Loan and/or the Investment;

 

  (v)

any self-declared exclusion by a bidder that occurs prior to the contract award and is covered by the Exclusion Policy;

 

  (vi)

any non-compliance by it with any applicable Environmental and Social Law; and

 

  (vii)

any suspension, revocation or material modification of any Environmental and Social Approval.

and set out the action to be taken with respect to such matters;

 

  (d)

If the total cost of the Investment exceeds the estimated figure set out in Recital (A), the Borrower shall notify the Bank without delay and shall inform the Bank of its plans to fund the increased costs.

 

63


  (e)

The Borrower shall provide to the Bank, if so requested:

 

  (i)

a certificate of its insurers showing that all assets required in order to carry out the Investment are insured with reputable underwriters or insurance companies against those risks and to the extent as is usual for companies carrying on the same or substantially similar business; and

 

  (ii)

annually, a list of insurance policies in force covering any aspect of the Investment, together with confirmation of payment of the current premiums.

 

  2.

Information concerning the Borrower

 

  (a)

The Borrower shall deliver to the Bank:

 

  (i)

as soon as they become available but in any event within 180 (one hundred and eighty) days after the end of each of its financial years the Group’s, the Parent’s and the Borrower’s audited consolidated and unconsolidated (as applicable) annual report, balance sheet, cash flow statement, profit and loss account and auditors report for that financial year together with a Compliance Certificate signed by Authorised Signatory(ies);

 

  (ii)

as soon as they become available but in any event within 120 (one hundred and twenty days) days after the end of each of the relevant accounting periods the Group’s, the Parent’s and the Borrower’s interim consolidated and unconsolidated (as applicable) semi-annual report, balance sheet, profit and loss account and cash flow statement for the each of the first three quarters of each of its financial years together with a Compliance Certificate signed by Authorised Signatory(ies);

 

  (iii)

such further information, evidence or document concerning its general financial situation or such certificates of compliance with the undertakings of Article 7 (Borrower undertakings and representations) as the Bank may deem necessary or may reasonably require to be provided within a reasonable time;

 

  (iv)

any such further information, evidence or document concerning the compliance with the due diligence requirements of the Bank, including, but not limited to “know your customer” (KYC) or similar identification procedures, when requested and within a reasonable time; and

 

  (v)

such further information, evidence or document concerning the factual information or documents provided to the Bank for the purposes of entering into this Contract, as the Bank may deem necessary or may require to be provided within a reasonable time.

 

  (b)

The Borrower shall inform the Bank immediately (and, in respect of sub-paragraph (iii) below, promptly upon becoming aware) of:

 

  (i)

any Default or Event of Default having occurred or being threatened or anticipated;

 

  (ii)

to the extent permitted by law, any material litigation, arbitration, administrative proceedings or investigation carried out by a court, administration or similar public authority, which, to the best of its knowledge and belief is current, threatened or pending:

 

  (1)

against the Borrower or its Controlling entities or members of the Borrower’s management bodies in connection with Illegal Activities related to the Loan or the Investment; or

 

  (2)

which might if adversely determined result in a Material Adverse Change;

 

  (iii)

any Change in the Beneficial Ownership of the Borrower;

 

  (iv)

any Voluntary Non-EIB Prepayment Event that has occurred or is likely to occur; and

 

  (v)

any claim, action, proceeding, formal notice or investigation relating to any Sanctions concerning an Obligor or any Relevant Person.

 

64


  3.

Visits by the Bank

 

  (a)

The Borrower shall, and shall procure that each Obligor will, allow the Bank and, when either required by the relevant mandatory provisions of EU law or pursuant to the InvestEU Regulation, the competent EU institutions including the European Court of Auditors, the European Commission, the European Anti-Fraud Office, the European Public Prosecutor’s Office as well as persons designated by the foregoing (each a “Relevant Party”):

 

  (i)

to visit the sites, installations and works controlled by the Obligors comprising the Investment;

 

  (ii)

to interview executive representatives of each Obligor, and not obstruct contacts with any other person involved in or affected by the Investment; and

 

  (iii)

subject to providing reasonable notice and at reasonable times, to conduct such investigations, inspections, on the spot audits and checks as they may wish and review the Obligors’ books and records in relation to the execution of the Investment and to be able to take copies of related documents to the extent not prohibited by the law.

 

  (b)

The Borrower shall, and shall procure that each Obligor will, provide the Bank and any Relevant Party, or ensure that the Bank and any Relevant Party is provided, with all necessary assistance for the purposes described in this Paragraph 3 (Visits by the Bank), including access to information, facilities and documentation for the purposes described in this paragraph.

 

  (c)

In the case of a genuine allegation, complaint or information with regard to Illegal Activities related to the Loan and/or the Investment, the Borrower shall consult with the Bank in good faith regarding appropriate actions. In particular, if it is proven that a third party committed Illegal Activities in connection with the Loan and/or the Investment with the result that the Loan was misapplied, the Bank may, without prejudice to the other provisions of this Contract, inform the Borrower if, in its view, the Borrower should take appropriate recovery measures against such third party. In any such case, the Borrower shall in good faith consider the Bank’s views and keep the Bank informed.

 

  4.

Disclosure and publication

The Borrower acknowledges and agrees that:

 

  (a)

it will use the emblem of the European Union or a reference to the EU, as appropriate, in a visible way in all its press releases, communications materials, the social media, as well as in all contractual documentation directly related to the Investment;

 

  (b)

the Bank may be obliged to communicate information relating to the Borrower and the Investment to any competent institution or body of the European Union in accordance with the relevant mandatory provisions of European Union law or pursuant to the InvestEU Regulation;

 

  (c)

the Bank and/or the European Commission may showcase this Investment by way of, among others, audio visual material or print publications and including information on the name and address of the Borrower, the financing form and the sector of activity of the Investment;

 

  (d)

the Bank may publish in its website or produce press releases containing information related to the financing provided pursuant to this Contract with support under the InvestEU Fund, upon signature of this Contract, the Bank may publicise on social media or produce a press release and publish on its website information relating to the financing provided pursuant to the Contract, including the name, locality and country of establishment of the Borrower and the type of financial support received under this Contract;

 

65


  (e)

unless the Borrower, prior to receiving financial support under the InvestEU Fund, declares in writing to the Bank (including by way of representation in this Contract) that the below publication by the Bank:

 

  (i)

risks harming its commercial interests or threatening the rights and freedoms of the persons or entities concerned as protected by the Charter of Fundamental Rights of the European Union; or

 

  (ii)

would be illegal under the laws and regulations applicable to the Borrower,

the Bank shall annually publish on its website information on the Borrower, which shall include the name and address of the Borrower and the financing form of support under the InvestEU Fund; and

 

  (f)

if requested by the Bank, the Borrower undertakes to refer to this financing and any other financing granted by the Bank or financial instrument entered into with the Bank in its public communications up to and including the Final Availability Date.

 

66


Schedule J

Positive Phase II Study

The Bank shall be considered to have received evidence of a positive phase II study in case the Bank receives either one of the following evidence in form and substance satisfactory to the Bank (acting reasonably):

 

1.

IOB-022 Study: Cohort A (Lung);

For patients with PD-L1 TPS ≥ 50% with pembrolizumab, ORR is estimated to be 39% (Mok et al., 2019). An IOB-022 study for Cohort A (Lung) will constitute a positive phase II study in case of an ORR between 50-55% and/or mPFS 9.5 months or greater (the benchmark for NSCLC is mPFS 7.1).

 

2.

IOB-022 Study: Cohort B (SCCHN);

For patients with CPS ≥20 with pembrolizumab, ORR is reported at 23% (Burtness et al., 2019). An IOB-022 study for Cohort B (SCCHN) will constitute a positive phase II study in case of an ORR of 35% or greater and/or mPFS at least 5.4 months (the benchmark for SCCHN mPFS is 3.5m).

 

3.

IOB-032 Study: Cohort B (SCCHN); or

The primary endpoint is major pathological response (MPR) (defined as 10% or fewer viable cells at the time of surgery. MPR rates of 13% are reported with pembrolizumab alone in SCCHN. An IOB-032 study for Cohort B (SCCHN) will constitute a positive phase II study in case of an MPR of 25% or greater.

 

4.

IOB-032 Study: Cohort C (Melanoma);

MPR rates of 53% are reported with pembrolizumab alone in Melanoma. An IOB-032 study for Cohort C (Melanoma) will constitute a positive phase II study in case of an MPR of 73% or greater in this indication. This is a randomized cohort and will include patients from cohort A.

 

67

Exhibit 10.2

Contract number (FI No): 97869

Serapis No: 2024-0179

GUARANTEE AGREEMENT

IO BIOTECH (IEU LS)

 

By   IO Biotech, Inc.
  as Guarantor
in favour of   The European Investment Bank


 

TABLE OF CONTENTS

 

1  

DEFINITIONS AND INTERPRETATION

     3  
2  

FIRST DEMAND GUARANTEE

     6  
3  

AUTONOMY OF THE FIRST DEMAND GUARANTEE

     7  
4  

REINSTATEMENT

     8  
5  

SUBORDINATION AND DEFERRAL OF GUARANTOR’S RIGHTS

     8  
6  

DURATION

     9  
7  

REPRESENTATIONS AND WARRANTIES

     9  
8  

GENERAL UNDERTAKINGS

     12  
9  

INFORMATION TO THE BANK

     19  
10  

TAXES

     21  
11  

CURRENCY CONVERSION

     22  
12  

NOTICES

     22  
13  

TRANSFER AND CONTINUING OBLIGATIONS

     23  
14  

SEVERABILITY

     24  
15  

NO WAIVER

     24  
16  

SET-OFF

     24  
17  

AMENDMENTS

     24  
18  

GOVERNING LAW AND JURISDICTION

     24  
19  

ENTIRE AGREEMENT

     25  
20  

WAIVER OF JURY TRIAL

     25  
ANNEX I - AUTHORITIES OF THE SIGNATORIES OF THE GUARANTOR      26  
ANNEX II - EURIBOR      27  
SIGNATURES      29  

 

2


 

This guarantee agreement (this “Guarantee Agreement”) is entered into on 19 December 2024 by:

 

(1)

IO Biotech, Inc. (file no. 5924808) a Delaware corporation, having its registered office at 430 E 29th St., Suite 940, New York, NY 10016, United States of America (the “Guarantor”)

in favour of

 

(2)

The European Investment Bank having its seat at 100 blvd Konrad Adenauer, Luxembourg, L-2950 Luxembourg (the “Bank”)

- the Bank and the Guarantor together are referred to as the “Parties” and any of them is a “Party”.

WHEREAS

 

  (A)

pursuant to a finance contract dated 19 December 2024 (the “Finance Contract”) entered into between the Bank and IO Biotech ApS (CVR number 36 47 44 83) (the “Borrower”), the Bank has agreed to grant in favour of the Borrower a credit in the amount of up to EUR 37,500,000;

 

  (B)

as a condition precedent to the first disbursement under the Finance Contract, the Guarantor shall grant a first demand payment guarantee in favour of the Bank (the “First Demand Guarantee”) pursuant to this Guarantee Agreement;

 

  (C)

it is the intention of the Parties that in the event that the Credit (as defined in the Finance Contract) is repaid and the Finance Contract is terminated, this Guarantee Agreement and the Guarantor’s obligations hereunder shall remain in full force and effect until such time as the Warrant Issuance Agreement (as defined below) has been terminated and no further obligations are owed to the Bank thereunder;

 

  (D)

the entry into, execution and performance by the Guarantor of its obligations under this Guarantee Agreement have been duly authorised by the board of directors of the Guarantor and the signatories of the Guarantor are duly entitled and authorised to execute this Guarantee Agreement on its behalf (as set out in Annex I (Authorities of the signatories of the Guarantor)); and

 

  (E)

the Parties expressly agree that any reference in this Guarantee Agreement to the Finance Contract shall under no circumstances be construed as affecting the independent, unconditional and irrevocable nature of the First Demand Guarantee granted pursuant to this Guarantee Agreement.

NOW IT IS HEREBY AGREED AS FOLLOWS:

 

1

DEFINITIONS AND INTERPRETATION

 

1.1

Definitions. In this Guarantee Agreement:

Automatic Acceleration” has the meaning ascribed to such term in Article 9.5 (Automatic acceleration) of the Finance Contract.

Bank’s Account” has the meaning ascribed to such term in paragraph (c) of Clause 2.2.1.

Business Day” means any day other than a Saturday or a Sunday (a) where the Bank is open for business in Luxembourg, and (b) where referring to a payment in EUR, which is a TARGET Day.

Demand” has the meaning ascribed to such term in Clause 2.2.1.

Dispute” has the meaning ascribed to such term in Clauses 18.2 (Jurisdiction).

 

3


 

EUR” or “euro” means the lawful currency of the Member States of the European Union which adopt or have adopted it as their currency in accordance with the relevant provisions of the Treaty on European Union and the Treaty on the Functioning of the European Union.

EURIBOR” has the meaning given to it in Annex II (EURIBOR) hereto.

Finance Documents” has the meaning ascribed to such term in the Finance Contract.

Guarantee Agreement Term” means the period beginning on the date of this Guarantee Agreement and ending on the Termination Date.

Guaranteed Documents” means the Finance Documents (as defined in the Finance Contract) except for the Warrant Issuance Agreement, the Registration Rights Agreement, and any Warrant Agreement.

Guaranteed Event” means that an Obligor has not fulfilled in full when due any of its payment obligations towards the Bank (whether now existing or arising after the date of this Guarantee Agreement) under or in connection with any Guaranteed Document as well as all costs, attorney’s fees and expenses incurred by the Bank in connection with the collection or enforcement.

Guaranteed Obligations” means any and all obligations and liabilities (whether as principal debtor or as surety and whether actual or contingent) of the Parent, the Borrower and any other Obligor under or pursuant to the Finance Documents, including (but not limited to) interest, default interest and all costs, attorney’s fees and expenses incurred by the Bank in connection with the collection or enforcement.

Notification” has the meaning ascribed to such term in Clause 2.2.1.

Obligor” has the meaning ascribed to such term in the Finance Contract.

Other Guarantor” means a Guarantor (as defined in the Finance Contract) other than the Guarantor (as defined herein).

Payment Period” has the meaning ascribed to such term in Clause 2.2.2.

Permitted Security” means Security of the Guarantor and/or any Group Company which is permitted in accordance with paragraph (c) of Clause 8.1.19 (Negative pledge).

Registration Rights Agreement” has the meaning ascribed to such term in the Finance Contract.

Security” means any mortgage, pledge, lien, charge, assignment, hypothecation, or other security interest securing any obligation of any person or any other agreement or arrangement having a similar effect.

Subsidiary” has the meaning ascribed to such term in the Finance Contract.

T2” means the real time gross settlement system operated by the Eurosystem, or any successor system.

TARGET Day” means any day on which T2 is open for the settlement of payments in euro.

Tax” means any tax, levy, impost, duty or other charge or withholding of a similar nature (including any penalty or interest payable in connection with any failure to pay or any delay in paying any of the same) imposed by any government or public agency.

Termination Date” has the meaning ascribed to such term in Clause 6 (Duration).

US Bankruptcy Code” means Title 11 of the United States Code, 11 U.S.C. 101 et seq., entitled “Bankruptcy”.

US Debtor Relief Laws” means the US Bankruptcy Code and all other liquidation, conservatorship, bankruptcy, assignment for the benefit of creditors, moratorium, rearrangement, receivership, insolvency, reorganization, judicial management or similar debtor relief laws of the United States from time to time in effect and affecting the rights of creditors generally.

 

4


 

Warrant Agreements” has the meaning ascribed to such term in the Finance Contract.

Warrant Issuance Agreement” has the meaning ascribed to such term in the Finance Contract.

 

1.2

Interpretation. In this Guarantee Agreement, unless a contrary indication appears:

 

  (a)

any reference to:

 

  (i)

the “Bank”, the “Borrower” or the “Guarantor” shall be construed as to include its and any subsequent successors in title, permitted assigns and permitted transferees;

 

  (ii)

the “Finance Contract”, a “Finance Document”, a “Guaranteed Document”, this “First Demand Guarantee”, this “Guarantee Agreement” or any other agreement or instrument is a reference to such agreement or instrument as amended, novated, supplemented, extended or restated from time to time;

 

  (iii)

a “person” includes any person, firm, company, corporation, government, state or agency of a state or any association, trust or partnership (whether having separate legal personality or not);

 

  (iv)

a “regulation” includes any regulation, rule, official directive, request or guideline (whether or not having the force of law) of any governmental, intergovernmental or supranational body, agency, department or regulatory, self-regulatory or other authority or organisation;

 

  (v)

a provision of law or a treaty are references to that provision as amended or re-enacted;

 

  (vi)

law” or “laws” mean (a) any applicable law and any applicable treaty, constitution, statute, legislation, decree, normative act, rule, regulation, judgement, order, writ, injunction, determination, award or other legislative or administrative measure or judicial or arbitral decision in any jurisdiction which is binding or applicable case law, and (b) EU Law;

 

  (vii)

applicable law”, “applicable laws” or “applicable jurisdiction” means (a) a law or jurisdiction applicable to the Guarantor, its rights and/or obligations (in each case arising out of or in connection with this Guarantee Agreement), its capacity and/or assets and/or the Investment; and/or, as applicable, (b) a law or jurisdiction (including in each case the Bank’s Statute) applicable to the Bank, its rights, obligations, capacity and/or assets; and

 

  (viii)

save as otherwise provided, a time of day is a reference to Luxembourg time.

 

  (b)

References to Clauses, Recitals and Annexes are, save if explicitly stipulated otherwise, references respectively to clauses, recitals, schedules and annexes to this Guarantee Agreement. All Recitals and Annexes form part of this Guarantee Agreement.

 

  (c)

Clauses’ and Annexes’ headings are for ease of reference only and shall not impact the interpretation of this Guarantee Agreement.

 

  (d)

Words importing the singular shall include the plural form and vice versa.

 

  (e)

A term used in any notice given under or in connection with this First Demand Guarantee or this Guarantee Agreement has the same meaning as ascribed to it in this Guarantee Agreement.

 

  (f)

Unless this Guarantee Agreement provides otherwise or the context otherwise requires, a term which is defined (or expressed to be subject to a particular construction) in the Finance Contract (including any term defined in the Finance Contract) shall have the same meaning (or be subject to the same construction) in this Guarantee Agreement. For the avoidance of doubt, this shall apply also after the Bank has confirmed to the Borrower in writing that all amounts owed by the Borrower under or in connection with the Finance Contract have been irrevocably and unconditionally paid in full.

 

5


2

FIRST DEMAND GUARANTEE

 

2.1

First Demand Guarantee. The Guarantor hereby irrevocably and unconditionally guarantees to the Bank as principal debtor and not merely as a surety (in Danish: “kaution”) by way of an on-demand guarantee (in Danish: “anfordringsgaranti”) to pay upon the Bank’s first written demand following a Guaranteed Event, without raising any defences or objections, set-off or counterclaim and without verification of the legal ground, any amount of the Guaranteed Obligations specified by the Bank, plus any interest, taxes or fiscal charges, duties, expenses, fees, rights, levies, indemnities, damages or any other sum which may from time to time become due or payable by the Obligors to the Bank under or pursuant to the Guaranteed Documents (including, without limitation, all amounts which, but for any US Debtor Relief Law, would become due and payable and all interest accruing after the commencement of any proceeding under a US Debtor Relief Law at the rate provided for in the Finance Contract, whether or not allowed in any such proceeding). Notwithstanding anything to the contrary herein, upon any Automatic Acceleration Event any presentment, demand, protest or notice of any kind required by the foregoing clauses are expressly waived.

 

2.2

Demands and payments

 

2.2.1

Subject to Clause 4 (Reinstatement), any demand made by the Bank to the Guarantor under this Guarantee Agreement (each, a “Demand”) shall be made by way of a written notification addressed by the Bank to the Guarantor, sent in accordance with the provisions set forth in Clause 12 (Notices) below and having the following content (each a “Notification”):

 

  (a)

specifying that the Bank is making a Demand under this Guarantee Agreement;

 

  (b)

specifying the amount due and payable by the Guarantor as well as the currency of payment of such sums;

 

  (c)

providing details of the relevant bank account into which payment should be made (the “Bank’s Account”) together with relevant instructions as to how payment should be made (if any); and

 

  (d)

specifying and warranting that a Guaranteed Event has occurred,

it being understood that the Bank shall be under no obligation to provide the Guarantor with any additional document nor to support its claim with any other justification or evidence.

 

2.2.2

The Guarantor shall make the payment requested in the Notification within five Business Days as from the date of receipt (included) of the relevant Notification (the “Payment Period”) and in the currency as requested within the Notification.

 

2.2.3

The Bank is entitled to request the payment of any amount in one or several instalments and the Bank shall not be limited in how many Demands and Notifications are made.

 

2.3

Independent payment obligations. The Guarantor expressly acknowledges that each Demand made in accordance with this Clause 2 generates an independent payment obligation toward the Bank.

 

2.4

Guarantee limitation - fraudulent conveyance. Any term or provision of this Clause 2 or any other term in this Guarantee Agreement or the Finance Contract notwithstanding, the maximum aggregate amount of the obligations for which the Guarantor shall be liable under this Guarantee Agreement or the Finance Contract shall in no event exceed an amount equal to the largest amount that would not render such Guarantor’s obligations under this Guarantee Agreement or the Finance Contract subject to avoidance under applicable US Debtor Relief Laws, in all cases before taking into account any liabilities under any other guarantee by such Guarantor.

 

6


3

AUTONOMY OF THE FIRST DEMAND GUARANTEE

 

3.1

Autonomy of the First Demand Guarantee. Notwithstanding anything to the contrary herein or in any other Finance Document, this First Demand Guarantee is by agreement of the Parties meant to be independent and separate from the obligations of the Obligors under the Finance Documents and is a continuing guarantee which will extend to the ultimate balance of sums payable by the Obligors under the Guaranteed Documents, regardless of any intermediate payment or discharge of any sum payable by the Obligors in whole or in part and the obligations of the Guarantor hereunder shall be obligations of the Guarantor as principal debtor and not as a surety (in Danish: “kaution”) or a surety upon first demand or a joint obligation as a borrower and the Guarantor undertakes to pay the amounts so demanded under or pursuant to this Guarantee Agreement unconditionally, irrevocably, upon first demand and without raising any defences or objections, set-off or counterclaim and without verification of the legal ground.

 

3.2

No defence

 

3.2.1

The Guarantor hereby expressly waives any right it has, or may have, which might reduce or extinguish its payment obligations under this Guarantee Agreement whether by way of set-off, lien, defence or otherwise.

 

3.2.2

Accordingly, the Guarantor acknowledges that it cannot raise any objection, ground or plea of any kind, in particular based on the Finance Documents, to refuse or delay the performance of its obligations under this Guarantee Agreement and/or any payment to be made by it under this Guarantee Agreement.

 

3.2.3

The obligations of the Guarantor will not be affected by an act, omission, matter or thing which relates to the principal obligation (or purported obligation) of the Obligors and which would reduce, release or prejudice any of the Guarantor’s obligations under this Guarantee Agreement, including any personal defences of each Obligors or any right of revocation or set-off of each Obligor.

 

3.2.4

In particular, but without limitation, the Guarantor acknowledges that its obligations to make payments hereunder are independent from and will not be affected by:

 

  (a)

the release of, or any time, waiver or consent granted to, any of the other Obligors from or in respect of its obligations under or in connection with any Finance Document;

 

  (b)

the taking, variation, compromise, exchange, renewal or release of, or refusal or neglect to perfect, take up or enforce, any rights against, or Security over assets of, the Obligors or any other person or any failure to realise full value of any Security;

 

  (c)

any incapacity or lack of power, authority or legal personality of or dissolution or a deterioration of the financial condition of the Obligors;

 

  (d)

the validity, legality, regularity and/or enforceability of any of the Finance Documents and the rights and obligations of the Obligors thereunder;

 

  (e)

any absence of action by the Bank against the Obligors to enforce the Bank’s rights under any of the Finance Documents;

 

  (f)

any waiver or consent given by the Bank with respect to any provisions of any of the Finance Documents;

 

  (g)

the occurrence of any event whatsoever which could prevent any of the Obligors from performing any of its obligations, including its payment obligations, under any of the Finance Documents, including in relation to the opening of any voluntary or judicial insolvency or restructuring proceedings in any jurisdiction; and

 

  (h)

any other circumstances which might otherwise constitute a legal discharge of or a defence for the Obligors.

 

3.2.5

Therefore, the Guarantor shall, in particular but without limitation, not be entitled to challenge any demand of payment under this Guarantee Agreement nor raise any objection, defence, exception, lien or right of set-off resulting from or related to:

 

  (a)

any provisions of any of the Finance Documents;

 

7


  (b)

any relationship between the Bank and any Obligor or the Guarantor and any Obligor, or the Guarantor and the Bank;

 

  (c)

any change in the legal and/or financial situation of any Obligor (including any merger, demerger or other form of legal or corporate reorganisation);

 

  (d)

any negligence or omission by the Bank, except in case of wilful misconduct or gross negligence; and

 

  (e)

any arrangement or agreement between the Bank and any Obligor including any cure period or delay which may be granted to any Obligor under any of the Finance Documents.

 

3.2.6

The Guarantor further undertakes not to exercise any action on the basis of a subrogation or any other form of recourse.

 

3.3

Other rights

 

3.3.1

The First Demand Guarantee granted pursuant to this Guarantee Agreement is in addition to any other rights, remedies or Security, which the Bank has, or may have, against any other person, including against the Borrower, the Guarantor or any other Obligor, whether provided for by law or otherwise.

 

3.3.2

The Guarantor hereby expressly accepts and acknowledges that the Bank will not be required to proceed against or enforce any other rights, Security or claim payment from any other person before making a claim under this Guarantee Agreement.

 

4

REINSTATEMENT

Notwithstanding anything to the contrary in this Guarantee Agreement, if any payment made by the Guarantor to the Bank or any discharge given by the Bank (whether in respect of the obligations of the Guarantor or any Security securing those obligations or otherwise) is avoided or reduced as a result of any insolvency or any similar event, the liability of the Guarantor shall continue or be reinstated (as the case may be) as if the payment, discharge, avoidance or reduction had not occurred; and the Bank shall be entitled to recover the value or amount of that Security or payment from the Guarantor as if the payment, discharge, avoidance or reduction had not occurred.

 

5

SUBORDINATION AND DEFERRAL OF GUARANTOR’S RIGHTS

 

5.1

Until all amounts which may be or become payable by the Obligors under or in connection with the Guaranteed Documents have been irrevocably paid in full:

 

  (a)

any rights and claims of the Guarantor against the Borrower, and against any other person guaranteeing, or granting Security for, the amounts payable by any Obligor to the Bank under any Guaranteed Document resulting from any payment made to the Bank shall be subordinated to any outstanding claims of the Bank against the Obligors or other such persons; and

 

  (b)

the Guarantor will not:

 

  (i)

exercise any rights to be indemnified by any other Obligor or other person guaranteeing, or granting Security;

 

  (ii)

claim any contribution from any other guarantor or any other person guaranteeing, or granting Security;

 

  (iii)

claim any payments arising out of or based upon any right of subrogation which it may have by reason of performance by it of its obligations under the Guaranteed Documents; and

 

  (iv)

take the benefit (in whole or in part and whether by way of subrogation or otherwise) of any rights of the Bank under the Finance Documents or of any other guarantee or security taken pursuant to, or in connection with, the Finance Documents by the Bank.

 

8


5.2

If the Guarantor receives any benefit, payment or distribution in relation to such rights and claims it shall hold such benefit, payment or distribution in full segregated from its other assets and on trust for the Bank and shall promptly pay or transfer the same to the Bank for application in accordance with the Finance Contract.

 

6

DURATION

The First Demand Guarantee shall be valid from the date hereof until the date (the “Termination Date”) on which the Bank confirms to the Borrower in writing that all amounts owed by the Borrower under or in connection with the Guaranteed Documents have been irrevocably and unconditionally paid in full and that the Guaranteed Documents have been terminated. For the avoidance of doubt, the First Demand Guarantee will not lapse if the original of this Guarantee Agreement is returned to the Guarantor.

 

7

REPRESENTATIONS AND WARRANTIES

 

7.1

Representations and warranties. The Guarantor hereby represents and warrants to the Bank in respect of itself and, where applicable, the other Obligors:

 

7.1.1

Authorisations and binding obligations

 

  (a)

The Guarantor is a corporation, duly incorporated and validly existing under the laws of the State of Delaware.

 

  (b)

Each Obligor, other than the Guarantor, is duly incorporated and validly existing as a company with limited liability under the laws of its jurisdiction of incorporation.

 

  (c)

No Obligor’s shares are publicly traded with the exception of the shares of the Guarantor.

 

  (d)

Each Obligor has the power to carry on its business as it is now being conducted and to own its property and other assets, and to execute, deliver and perform its obligations under the Finance Documents.

 

  (e)

Each Obligor has obtained all necessary Authorisations in connection with the execution, delivery and performance of the Finance Documents and in order to lawfully comply with its obligations thereunder, and in respect of the Investment, and all such Authorisations are in full force and effect and admissible in evidence.

 

  (f)

The execution and delivery of, the performance of each Obligor’s obligations under, and compliance with the provisions of, the Finance Documents do not and will not contravene or conflict with:

 

  (i)

subject to the Legal Reservations, any applicable law, statute, rule or regulation, or any judgement, decree or permit to which it is subject;

 

  (ii)

any agreement or other instrument binding upon it which might reasonably be expected to have a material adverse effect on its ability to perform its obligations under the Finance Documents; or

 

  (iii)

any provision of its constitutional documents.

 

  (g)

The obligations expressed to be assumed by each Obligor in each Finance Document to which it is a party are, subject to the Legal Reservations, legal, valid, binding and enforceable obligations.

 

7.1.2

No default or other adverse event

 

  (a)

There has been no Material Adverse Change since 17 December 2024.

 

  (b)

No event or circumstance which constitutes an Event of Default has occurred and is continuing unremedied or unwaived.

 

9


7.1.3

No proceedings

 

  (a)

No litigation, arbitration, administrative proceedings or investigation is current or to its knowledge is threatened or pending before any court, arbitral body or agency which has resulted or if adversely determined is reasonably likely to result in a Material Adverse Change, nor is there subsisting against it or any of its Subsidiaries any unsatisfied judgement or award.

 

  (b)

To the best of its knowledge and belief (having made due and careful enquiry) no material Environmental or Social Claim has been commenced or is threatened against any Obligor or any relevant Affiliate in relation to the Investment.

 

  (c)

As at the date of this Guarantee Agreement, no Obligor has taken any action to commence proceedings for, nor have any other steps been taken or legal proceedings commenced or, so far as the Borrower is aware, threatened against any Obligor for its insolvency, winding up or dissolution, or for any Obligor to enter into any arrangement or compositions for the benefit of creditors, or for the appointment of an administrator, receiver, administrative receiver, examiner, trustee or similar officer.

 

7.1.4

Security. At the date of the Finance Contract, no Security exists over the assets of any Obligor or any Group Company other than Permitted Security.

 

7.1.5

Ranking

 

  (a)

The payment obligations of each Obligor under the Finance Documents rank not less than pari passu in right of payment with all other present and future unsecured and unsubordinated obligations under any of its debt instruments except for obligations mandatorily preferred by law applying to companies generally.

 

  (b)

No financial covenants have been concluded with any other creditor of any Obligor.

 

  (c)

No Voluntary Non-EIB Prepayment Event has occurred.

 

7.1.6

Anti-Corruption

 

  (a)

Each Obligor is in compliance with all applicable European Union and national legislation regarding Illegal Activities.

 

  (b)

No Obligor is engaged in any Illegal Activities and, to the best of the Guarantor’s knowledge, no Illegal Activities have occurred in connection with the Loan and the Investment.

 

7.1.7

Accounting and Tax

 

  (a)

The latest available consolidated and unconsolidated audited accounts of the Guarantor and the other Obligors have been prepared on a basis consistent with previous years and have been approved by its auditors and fairly presents, in all material respects, the financial condition and result of operations of the Guarantor and the other Obligors, as relevant.

 

  (b)

The accounting reference date of the Guarantor is 31 December.

 

  (c)

No Obligor is required to make any deduction for or on account of any Tax from any payment it may make under the Finance Documents.

 

  (d)

All Tax returns required to have been filed by each Obligor or on its behalf under any applicable law have been filed when due and contain the information required by applicable law to be contained in them.

 

  (e)

Each Obligor has paid when due all Taxes payable by it under applicable law except to the extent that it is contesting payment in good faith and by appropriate means.

 

  (f)

With respect to Taxes which have not fallen due or which it is contesting, each Obligor is maintaining reserves adequate for their payment and in accordance, where applicable, with GAAP.

 

  (g)

Under the laws of the jurisdiction of incorporation of each Obligor, it is not necessary that the Finance Documents be filed, recorded or enrolled with any court or other authority or that any stamp, registration or similar tax be paid on or in relation to the Finance Documents, or the transactions contemplated by the Finance Documents.

 

10


  (h)

No Obligor is a FATCA FFI.

 

7.1.8

Information provided

 

  (a)

Any information provided by any Group Company for the purposes of entering into the Finance Documents and any related documentation was true and accurate in all material respects as at the date it was provided or as at the date (if any) at which it is stated and continues to be true and accurate in all material respect as at the date of this Guarantee Agreement.

 

  (b)

The Group structure chart provided to the Bank pursuant to paragraph (i) of Schedule F (Initial Documentary Conditions Precedent) of the Finance Contract is true, complete and accurate in all material respects and represents the complete corporate structure of the Group as at the date of this Guarantee Agreement, and other than as set out therein, the Guarantor owns no other equity and/or shares in any other business entity.

 

7.1.9

No indebtedness. No Obligor has Indebtedness outstanding other than Permitted Indebtedness.

 

7.1.10

No immunity. No Obligor, nor any of its assets, is entitled to immunity from suit, execution, attachment or other legal process.

 

7.1.11

Pensions. The pension schemes for the time being operated by the Obligors (if any) are funded in accordance with their rules and to the extent required by law or otherwise comply with the requirements of any law applicable in the jurisdiction in which the relevant pension scheme is maintained.

 

7.1.12

Sanctions

No Obligor and/or any Relevant Person:

 

  (a)

is a Sanctioned Person; or

 

  (b)

is in breach of any Sanctions.

It is acknowledged and agreed that the representations set out in this Clause 7.1.12 are only sought by and given to the Bank to the extent that to do so would be permissible pursuant to any applicable anti-boycott rule of the EU such as Regulation (EC) 2271/96.

 

7.1.13

Other

 

  (a)

In respect of this Guarantee Agreement and the transaction contemplated by, referred to in, provided for or effected by this Guarantee Agreement, it has entered into this Guarantee Agreement:

 

  (i)

in good faith and for the purpose of carrying out its business;

 

  (ii)

on arm’s length commercial terms; and

 

  (iii)

without any intention to defraud or deprive of any legal benefit any other parties (such as third parties and in particular creditors other than the Bank) or to circumvent any applicable mandatory laws or regulations of any jurisdiction.

 

  (b)

The granting of this Guarantee Agreement is not disproportionate to its financial means.

 

  (c)

The Guarantor further represents that it has not incurred and does not intend to incur debts beyond its ability to pay as they mature.

 

7.2

Repeating representations

 

7.2.1

The representations and warranties set out in Clause 7.1 (Representations and warranties) are deemed to be repeated by the Guarantor (in respect of itself and, where applicable, the other Obligors), with reference to the facts and circumstances then subsisting, on the date of each Disbursement Acceptance, each Disbursement Date and each Payment Date (each as defined in the Finance Contract) by reference to the facts and circumstances then existing

 

11


7.2.2

Notwithstanding Clause 7.2.1, the representations and warranties set out in paragraph (a) of Clause 7.1.2 (No default or other adverse event), paragraph (c) of Clause 7.1.3 (No proceedings), Clause 7.1.4 (Security), paragraphs (b) and (c) of Clause 7.1.5 (Ranking), paragraph (b) of Clause 7.1.6 (Anti-Corruption), paragraphs (c) and (g) of Clause 7.1.7 (Accounting and Tax), paragraph (b) of Clause 7.1.8 (Information provided) and Clause 7.1.9 (No indebtedness) are deemed to be made on the date of this Guarantee Agreement only.

 

8

GENERAL UNDERTAKINGS

 

8.1

Undertakings. The Guarantor acknowledges and agrees that during the Guarantee Agreement Term:

 

8.1.1

Compliance with laws

 

  (a)

The Guarantor shall comply in all respects with all laws to which it or the Investment is subject, if failure so to comply would materially impair the ability of any Obligor to perform its obligations under any Finance Document.

 

  (b)

Notwithstanding paragraph (a) above, each Obligor shall comply in all respects with any laws to which it may be subject and the breach of which would constitute an Illegal Activity.

 

8.1.2

Disposal of assets

 

  (a)

Except as provided below, the Guarantor shall not, and shall procure that no Group Company shall, either in a single transaction or in a series of transactions whether related or not and whether voluntarily or involuntarily dispose of all or any part of any Group Company’s business, undertaking or assets (including any shares or security of any entity or a business or undertaking, or any interest in any of them).

 

  (b)

Paragraph (a) above does not apply to any such disposal:

 

  (i)

made with the prior written consent of the Bank;

 

  (ii)

made on arm’s length terms in the ordinary course of business of a Group Company (including, for the avoidance of doubt, any partnership and similar agreements);

 

  (iii)

made on arm’s length terms and at fair market value for cash, which is reinvested in assets of comparable or superior type, value and quality;

 

  (iv)

made on arm’s length terms in exchange for other assets comparable or superior as to type, value and quality;

 

  (v)

made by one Obligor to another Obligor;

 

  (vi)

made by a Group Company which is not an Obligor to another Group Company;

 

  (vii)

constituted by a licence of Intellectual Property Rights made on arm’s length terms;

 

  (viii)

made in relation to non-material assets which have depreciated to less than 25% (twenty five per cent.) of their initial value or which are obsolete;

 

  (ix)

disposals made in relation to non-core assets on arm’s length terms (including disposals of IO112 or IO170);

 

  (x)

made on arm’s length terms and consisting of a conveyance to a third party of a right to receive royalties on future sales pursuant to a Royalty Agreement as set out in paragraph (g) of Clause 8.1.12 (Indebtedness);

 

  (xi)

excluding any disposal otherwise permitted under sub-paragraphs (ii) to (ix) above, disposals where the higher of the market value or consideration receivable for such disposals does not exceed (x) 10% (ten per cent.) of Total Assets during any financial year, and (y) 25% (twenty five per cent.) of Total Assets during the Guarantee Agreement Term; or

 

12


  (xii)

arising as a result of Permitted Security,

provided that, in respect of sub-paragraphs (ii) to (iv), (viii) and (x) to (xi) above (unless otherwise agreed between the Parties), the disposal is not of assets forming part of the Investment or shares in subsidiaries holding assets forming part of the Investment, which may not be disposed of unless either (a) the Guarantor or the Borrower consults the Bank in relation to such disposal, and the Bank approves the disposal, or (b) the proceeds of the disposal are applied to prepay the Bank in accordance with article 5.3.5 (Disposals) of the Finance Contract,

and further provided that any disposal on arm’s length terms of IO112 or IO170 completed before the relevant asset enters phase II development shall not require prepayment pursuant to Article 5.3.5 (Disposals) of the Finance Contract.

For the purposes of this Clause 8.1.2, “dispose” and “disposal” includes any act effecting sale, transfer, lease or other disposal.

 

8.1.3

Insurances. The Guarantor shall, and shall procure that each Group Company shall, maintain insurances on and in relation to its business and assets with reputable underwriters or insurance companies against those risks and to the extent as is usual for companies carrying on the same or substantially similar business.

 

8.1.4

Change in business. The Guarantor shall procure that no substantial change is made to the general nature of the business of the Guarantor or the Group as a whole from that carried on at the date of this Guarantee Agreement.

 

8.1.5

Merger. The Guarantor shall not, and shall procure that no Group Company shall, enter into any amalgamation, demerger, merger or corporate reconstruction unless:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

that merger implements an acquisition permitted under Clause 8.1.11 (Acquisitions) below, provided that a Group Company (and if the Borrower or the Guarantor is part of that merger, the Borrower or the Guarantor (as applicable)) is the continuing entity; or

 

  (c)

such amalgamation, demerger, merger or corporate reconstruction does not result in a Material Adverse Change and is on a solvent basis, and provided that:

 

  (i)

only Group Companies are involved;

 

  (ii)

the resulting entity will not be incorporated or located in a country which is in a jurisdiction that is blacklisted by any Lead Organisation in connection with activities such as money laundering, financing of terrorism, tax fraud and tax evasion or harmful tax practices as such blacklist may be amended from time to time;

 

  (iii)

if the Borrower is involved, (1) the rights and obligations of the Borrower under the Finance Contract will remain with the Borrower, (2) the surviving entity will be the Borrower and the statutory seat of the Borrower would not as a result of such merger be transferred to a different jurisdiction, (3) the merger will not have an effect on the validity, legality or enforceability of the Borrower’s obligations under the Finance Contract or any other Finance Document, and (4) all of the business and assets of the Borrower are retained by it; and

 

  (iv)

if the Guarantor is involved, (i) the rights and obligations of the Guarantor under the Warrant Issuance Agreement will remain with the Guarantor, (ii) the surviving entity will be the Guarantor and the statutory seat of the Guarantor would not as a result of such merger be transferred to a different jurisdiction, (iii) the merger will not have an effect on the validity, legality or enforceability of the Guarantor’s obligations under the Warrant Issuance Agreement; and (iv) all of the business and assets of the Guarantor are retained by it.

 

13


8.1.6

Books and records. The Guarantor shall, and shall procure that each Obligor shall, ensure that it has kept and will continue to keep proper books and records of account, in which full and correct entries shall be made of all financial transactions and its assets and business, including expenditures in connection with the Investment, in accordance with GAAP as in effect from time to time.

 

8.1.7

Ownership

 

  (a)

The Guarantor shall maintain more than 50% (fifty per cent.) of the share capital, directly or indirectly, of each of its Material Subsidiaries, unless a prior written consent of the Bank is received by the Guarantor.

 

  (b)

The Guarantor shall in aggregate maintain more than 50% (fifty per cent.) of the share capital, directly or indirectly, of each Other Guarantor, unless prior written consent of the Bank is received by the Guarantor.

 

  (c)

The Guarantor shall maintain 100% (one hundred per cent.) of the share capital of the Borrower, unless a prior written consent of the Bank is received by the Guarantor.

 

  (d)

The Guarantor shall immediately notify the Bank in the event of a new entity becoming a Subsidiary of the Guarantor through any means, including but not limited to acquisition, creation and spin-off.

 

  (e)

The undertakings in paragraphs (a), (b) and (c) above shall be calculated in accordance with GAAP as applied by the Guarantor on the date of this Guarantee Agreement and as GAAP is amended from time to time and tested annually.

 

8.1.8

Further assurance. The Guarantor shall promptly do all such acts or execute all such documents (including notices and instructions) as the Bank may specify (and in form and substance reasonably satisfactory to the Bank) to ensure performance by the Guarantor of its obligations under this Guarantee Agreement (provided that this Clause 8.1.8 shall not in itself entitle the Bank to require the Guarantor to provide, or procure the provision of, any Security in favour of the Bank).

 

8.1.9

Notification duty. It shall inform the Bank immediately of any Default or Event of Default having occurred or being threatened or anticipated.

 

8.1.10

Maintenance of Status. The Guarantor shall, and shall procure that each other Group Company shall, remain duly incorporated and validly existing as a corporate entity with limited liability under the jurisdiction in which it is incorporated and that it will have no centre of main interests, permanent establishment or place of business outside the jurisdiction in which it is incorporated, and that it will continue to have the power to carry on its business as it is now being conducted and continue to own its property and other assets.

 

8.1.11

Acquisitions. The Guarantor shall not, and shall procure that no Group Company shall, invest in or acquire any entity or a business going concern or an undertaking (whether whole or substantially the whole of the assets or business), or any division or operating unit thereof, or any shares or securities of any entity or a business or undertaking (or in each case, any interest in any of them) (or agree to any of the foregoing), save for an acquisition or investment:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

made by a Group Company as part of treasury transactions;

 

  (c)

of assets pursuant to disposals permitted pursuant to sub-paragraphs (b)(v) and (b)(vi) of Clause 8.1.2 (Disposal of assets);

 

  (d)

consisting of the formation of a new company or the acquisition of an off-the-shelf company (i.e. an existing, registered, but not operating company), provided that;

 

  (i)

such entity has not yet commenced commercial operations, has no liabilities and has not generated any loss from any activity;

 

  (ii)

such entity is incorporated in a country that is a member of either or both of the European Union or the Organisation of Economic Co-Operation and Development; and

 

14


  (iii)

no Event of Default is continuing on the date the relevant acquisition agreement is entered into or would occur as a result of the acquisition;

 

  (e)

by a Group Company of all the shares or other ownership interests in any limited liability company or corporation, limited liability partnership or any equivalent company, provided that:

 

  (i)

such entity has commenced commercial operations;

 

  (ii)

such entity is incorporated in a country that is a member of either or both of the European Union or the Organisation of Economic Co-Operation and Development; and

 

  (iii)

no Event of Default is continuing on the date the relevant acquisition agreement is entered into or would occur as a result of the acquisition;

 

  (f)

of shares or other ownership interest in any limited liability company or corporation, provided that such acquisition is directly or indirectly funded by way of equity into the Parent or shareholder loans to the Parent subordinated to the satisfaction of the Bank; and

 

  (g)

of shares or other ownership interests in any limited liability company or corporation, limited liability partnership or any equivalent company or of the whole or substantially the whole of the assets or business of such entity or of any division or operating unit thereof, the consideration for which is paid in shares or does not exceed an amount in aggregate for the Group equal to 5% of Total Assets at the date of the acquisition, provided that:

 

  (i)

no Event of Default is continuing on the date the relevant acquisition agreement is entered into or would occur as a result of the acquisition;

 

  (ii)

the acquired entity is engaged in a business similar or complementary to the business carried on by the Group as at the date of this Contract;

 

  (iii)

the acquired entity is not incorporated or located in a jurisdiction that is blacklisted by any Lead Organisation in connection with activities such as money laundering, financing of terrorism, tax fraud and tax evasion or harmful tax practices as such blacklist may be amended from time to time;

 

  (iv)

in respect of any acquisition where the consideration exceeds EUR 10,000,000 (ten million euro) (or its equivalent in another currency or currencies), legal and financial due diligence reports (including customary reliance letters in favour of the Bank) and a business plan (in the form of the most recent budget adjusted for the expected effects of the acquisition) in respect of the 3 (three) next following financial years and any other due diligence reports received in connection with the acquisition (if any) are provided to the Bank; and

 

  (v)

the Borrower provides a Compliance Certificate for the 2 (two) 12 (twelve) month financial periods immediately following the acquisition, updated on a pro forma basis as if the acquisition has occurred.

 

8.1.12

Indebtedness. The Guarantor shall not, and shall procure that no other Group Company shall, incur any Indebtedness, save for Indebtedness incurred:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

under the Finance Contract;

 

  (c)

under any loan permitted pursuant to Clause 8.1.16 (Restrictions on loans);

 

  (d)

in the ordinary course of business with trade suppliers or customers;

 

  (e)

in the ordinary course of business under an agreement to pay discounts, rebates or chargebacks on a Group Company’s product;

 

  (f)

and which is subordinated to the Credit on terms satisfactory to the Bank;

 

  (g)

under a royalty deal agreement (a “Royalty Agreement”) under which the Borrower may receive one or several lump sum payment(s) in consideration for a percentage of the future sales of a product, provided that the annual aggregate amount to be paid by the Borrower under the Royalty Agreement does not exceed an amount equal to 10% (ten per cent.) of the annual net sales of the product as defined and determined in such Royalty Agreement;

 

15


  (h)

under any convertible loans and/or convertible loan notes issued by the Parent, provided that:

 

  (i)

no payments of interest or repayments or prepayments of principal are scheduled or made prior to the latest Maturity Date; and

 

  (ii)

either:

 

  (1)

the Indebtedness thereunder and the relevant creditor’s rights are subordinated to the Credit on terms acceptable to the Bank; or

 

  (2)

all Indebtedness thereunder automatically converts into common equity of the Parent immediately upon the occurrence of the Parent’s insolvency;

 

  (i)

under any Finance Lease if the aggregate liability in respect of the equipment leased under all Finance Leases does not at any time exceed an amount equal to 10% of Fixed Assets;

 

  (j)

under any factoring arrangement, provided that the aggregate face value of outstanding receivables subject to such arrangement does not at any time exceed an amount equal to 10% of Trade Receivables;

 

  (k)

under Permitted Hedging;

 

  (l)

under any letters of credit provided that such Indebtedness does not, singularly or in aggregate, exceed an amount equal to 10% of Trade Payables;

 

  (m)

in respect of a Permitted Guarantee; or

 

  (n)

not permitted by the preceding paragraphs and the outstanding amount of which, when aggregated with the amount of all indebtedness permitted pursuant to paragraphs (i), (j), (l) and (m) above, does not exceed an amount in aggregate for the Group at any time equal to 10% (ten per cent.) of Total Assets.

 

8.1.13

Guarantees. The Guarantor shall not, and shall procure that no other Group Company shall, issue or allow to remain outstanding any guarantees in respect of any liability or obligation of any person save for:

 

  (a)

with the prior written consent of the Bank; or

 

  (b)

guarantees issued in the ordinary course of trade by any Group Company:

 

  (i)

under any Guarantee Agreement;

 

  (ii)

under any negotiable instruments;

 

  (iii)

in connection with any performance bond; or

 

  (iv)

in connection with any Permitted Indebtedness;

 

  (c)

guarantees issued by one Obligor for the obligations of another Obligor;

 

  (d)

guarantees issued by a Group Company which is not an Obligor for the obligations of another Group Company;

 

  (e)

customary guarantee and indemnity obligations in connection with any disposal permitted pursuant to Clause 8.1.2 (Disposal of assets), provided that the Group’s liability under any such guarantee and indemnity obligation does not exceed an amount equal to the cash consideration received by the Group in connection with that disposal; and

 

  (f)

any other guarantees the aggregate liabilities of which do not at any time exceed an amount equal to 5% of Total Assets.

 

16


8.1.14

Hedging. The Guarantor shall not, and shall procure that no other Group Company shall, enter into any derivative transaction other than Permitted Hedging, where “Permitted Hedging” means:

 

  (a)

any derivative transaction by a Group Company to hedge actual or projected exposure arising in the ordinary course of trading and not for speculative purposes; and

 

  (b)

any derivative instrument of a Group Company which is accounted for on a hedge accounting basis but is not entered into for speculative purposes.

 

8.1.15

Restrictions on distributions. The Guarantor shall not declare or distribute dividends, or return or purchase shares, save for with the prior written consent of the Bank.

 

8.1.16

Restrictions on loans. The Guarantor shall not, and shall ensure that no other Group Company will, be a creditor in respect of any Indebtedness, save for:

 

  (a)

any trade credit extended by any Group Company to its customers on normal commercial terms and in the ordinary course of its trading activities;

 

  (b)

(subject to compliance with Clause 8.1.17 (Restrictions on Intercompany Loans)) loans by an Obligor to another Obligor;

 

  (c)

(subject to compliance with Clause 8.1.17 (Restrictions on Intercompany Loans)) any loan made by a Group Company (other than an Obligor) to another member of the Group;

 

  (d)

(subject to compliance with Clause 8.1.17 (Restrictions on Intercompany Loans)) loans by an Obligor to a member of the Group which is not an Obligor, provided that the aggregate outstanding amount of such loans does not exceed an amount equal to the higher of USD 1,000,000 (one million United States dollars) (or its equivalent in another currency or currencies) and 1% of Total Assets;

 

  (e)

any other loans not exceeding in aggregate a principal amount of USD 100,000 (one hundred thousand United States dollars) (or its equivalent in another currency or currencies); or

 

  (f)

any other Indebtedness or loan advanced to or made available by any Group Company with the prior written consent of the Bank.

 

8.1.17

Restrictions on Intercompany Loans. The Guarantor shall not, and shall procure that no other Group Company shall, make any payment in respect of any Intercompany Loan, save for:

 

  (a)

with the prior written consent of the Bank;

 

  (b)

where the lender of the Intercompany Loan is an Obligor; or

 

  (c)

payments to a Group Company as a result of a solvent liquidation or reorganisation of a Group Company which is not an Obligor.

 

8.1.18

Intellectual Property Rights. The Guarantor shall, and shall procure that each other Group Company shall:

 

  (a)

obtain, safeguard and maintain its rights with respect to the Intellectual Property Rights required for the implementation of the Investment in accordance with the Finance Contract, including complying with all material contractual provisions and that the implementation of the Investment in accordance with the Finance Contract will not result in the infringement of the rights of any person with regard to the Intellectual Property Rights; and

 

  (b)

ensure that any Intellectual Property Rights required for the implementation of the Investment will be owned by or licensed to the Borrower and/or other Group Companies, and where such Intellectual Property Rights which are owned by a Group Company are capable of registration, are registered to such party.

 

8.1.19

Negative pledge

 

  (a)

The Guarantor shall not, and shall procure that no other Group Company shall, create or permit to subsist any Security over any of its assets.

 

17


  (b)

For the purposes of this Clause 8.1.19, the term Security shall also include any arrangement or transaction on assets or receivables or money (such as the sale, transfer or other disposal of assets on terms whereby they are or may be leased to or re-acquired by any Group Company, the sale, transfer or other disposal of any receivables on recourse terms or any arrangement under which money or the benefit of a bank account or other account may be applied or set off or any preferential arrangement having a similar effect) in circumstances where the arrangement or transaction is entered into primarily as a method of raising credit or of financing the acquisition of an asset.

 

  (c)

Paragraph (a) above does not apply to any Security listed below:

 

  (i)

any netting or set-off arrangement entered into by any Group Company in the ordinary course of its banking arrangements for the purpose of netting debit and credit balances;

 

  (ii)

any payment or close out netting or set-off arrangement pursuant to any Permitted Hedging, but excluding any Security under a credit support arrangement in relation to a hedging transaction;

 

  (iii)

any lien arising by operation of law and in the ordinary course of trading;

 

  (iv)

any Security over or affecting any asset acquired by a Group Company after the date of this Guarantee Agreement if:

 

  (1)

the Security was not created in contemplation of the acquisition of that asset by a Group Company;

 

  (2)

the principal amount secured has not been increased in contemplation of or since the acquisition of that asset by a Group Company; and

 

  (3)

the Security is removed or discharged within 3 (three) months of the date of acquisition of such asset;

 

  (v)

any Security over or affecting any asset of any company which becomes a Group Company after the date of this Guarantee Agreement, where the Security is created prior to the date on which that company becomes a Group Company, if:

 

  (1)

the Security was not created in contemplation of the acquisition of that company;

 

  (2)

the principal amount secured has not increased in contemplation of or since the acquisition of that company; and

 

  (3)

the Security is removed or discharged within 3 (three) months of that company becoming a Group Company;

 

  (vi)

any Security arising under any retention of title, hire purchase or conditional sale arrangement or arrangements having similar effect in respect of goods supplied to a Group Company in the ordinary course of trading and on the supplier’s standard or usual terms and not arising as a result of any default or omission by any Group Company; or

 

  (vii)

any Security securing indebtedness the principal amount of which (when aggregated with the principal amount of any other indebtedness which has the benefit of Security given by a Group Company other than any permitted under sub-paragraphs (i) to (vi) above) does not exceed USD 1,000,000 (one million United States dollars) (or its equivalent in another currency or currencies).

 

8.1.20

Other undertakings. The Guarantor shall take note of the Bank’s group statement on tax fraud, tax evasion, tax avoidance, aggressive tax planning, money laundering and financing of terrorism (as published on the Bank’s website and as may be amended from time to time).

 

8.1.21

Data protection. Before disclosing any personal data (other than mere contact information relating to the Guarantor’s personnel involved in the management of this Guarantee Agreement) to the Bank in connection with this Guarantee Agreement, the Guarantor shall ensure that each data subject of those personal data:

 

  (a)

has been informed of the disclosure (including the categories of personal data to be disclosed); and

 

18


 

  (b)

has the information in (or has been provided with an appropriate link to) the Bank’s privacy statement in relation to its lending and investment activities set out at the relevant time at https://www.eib.org/en/privacy/lending (or such other address as the Bank may notify to the Guarantor in writing from time to time).

 

8.1.22

Sanctions

The Guarantor shall not, and shall procure that no Obligor shall, directly or indirectly:

 

  (a)

enter into a business relationship with, and/or make any funds and/or economic resources available to, or for the benefit of, any Sanctioned Person in connection with the Investment; or

 

  (b)

use all or part of the proceeds of the Loan or lend, contribute or otherwise make available such proceeds to any person in any manner that would result in a breach by itself and/or by the Bank of any Sanctions; or

 

  (c)

fund all or part of any payment under this Guarantee Agreement out of proceeds derived from activities or businesses with a Sanctioned Person, a person in breach of the Sanctions or in any manner that would result in a breach by itself and/or by the Bank of any Sanctions.

It is acknowledged and agreed that the undertakings set out in this Clause 8.1.22 are only sought by and given to the Bank to the extent that to do so would be permissible pursuant to any applicable anti-boycott rule of the EU such as Regulation (EC) 2271/96.

 

9

INFORMATION TO THE BANK

 

9.1

Information concerning the Group

 

  (a)

The Guarantor shall deliver to the Bank:

 

  (i)

as soon as they become available but in any event within 180 (one hundred and eighty) days after the end of each of its financial years the Guarantor’s audited consolidated annual report, balance sheet, cash flow statement, profit and loss account and auditors report for that financial year;

 

  (ii)

as soon as they become available but in any event within 120 (one hundred and twenty days) days after the end of each of the relevant accounting periods the Guarantor’s interim consolidated semi-annual report, balance sheet, profit and loss account and cash flow statement for the each of the first three quarters of each of its financial years;

 

  (iii)

such further information, evidence or document concerning its general financial situation or such certificates of compliance with the undertakings of Clause 8 (General Undertakings) as the Bank may deem necessary or may reasonably require to be provided within a reasonable time;

 

  (iv)

any such further information, evidence or document concerning the compliance with the due diligence requirements of the Bank, including, but not limited to “know your customer” (KYC) or similar identification procedures, when requested and within a reasonable time; and

 

  (v)

such further information, evidence or document concerning the factual information or documents provided to the Bank for the purposes of entering into this Guarantee Agreement, as the Bank may deem necessary or may require to be provided within a reasonable time.

 

  (b)

The Guarantor shall inform the Bank immediately (and, in respect of sub-paragraph (iii) below, promptly upon becoming aware) of:

 

  (i)

any Default or Event of Default having occurred or being threatened or anticipated;

 

  (ii)

to the extent permitted by law, any material litigation, arbitration, administrative proceedings or investigation carried out by a court, administration or similar public authority, which, to the best of its knowledge and belief is current, threatened or pending:

 

19


  (1)

against the Guarantor or its Controlling entities or members of the Guarantor’s management bodies in connection with Illegal Activities related to the Loan or the Investment; or

 

  (2)

which might if adversely determined result in a Material Adverse Change;

 

  (iii)

any Change in the Beneficial Ownership of any Group Company; and

 

  (iv)

any claim, action, proceeding, formal notice or investigation relating to any Sanctions concerning an Obligor or any Relevant Person.

 

9.2

Visits by the Bank

 

  (a)

The Guarantor shall, and shall procure that each Obligor shall, allow the Bank and, when either required by the relevant mandatory provisions of EU law or pursuant to the InvestEU Regulation the competent EU institutions including the European Court of Auditors, the European Commission, the European Anti-Fraud Office, the European Public Prosecutor’s Office as well as persons designated by the foregoing (each a “Relevant Party”):

 

  (i)

to visit the sites, installations and works controlled by the Obligors comprising the Investment;

 

  (ii)

to interview executive representatives of each Obligor, and not obstruct contacts with any other person involved in or affected by the Investment; and

 

  (iii)

to conduct such investigations, inspections, on the spot audits and checks as they may wish and review the Obligors’ books and records in relation to the execution of the Investment and to be able to take copies of related documents to the extent not prohibited by the law.

 

  (b)

The Guarantor shall, and shall procure that each Obligor shall, provide the Bank and any Relevant Party is provided, with all necessary assistance for the purposes described in this Clause 9.2, including access to information, facilities and documentation for the purposes described in this Clause 9.2.

 

  (c)

In the case of a genuine allegation, complaint or information with regard to Illegal Activities related to the Group, Loan and/or the Investment, the Guarantor shall, and shall procure that each Obligor shall, consult with the Bank in good faith regarding appropriate actions. In particular, if it is proven that a third party committed Illegal Activities in connection with the Loan and/or the Investment with the result that the Loan was misapplied, the Bank may, without prejudice to the other provisions of the Finance Documents, inform the Guarantor if, in its view, the Guarantor should take appropriate recovery measures against such third party. In any such case, the Guarantor shall in good faith consider the Bank’s views and keep the Bank informed.

 

9.3

Disclosure and publication.

The Guarantor acknowledges and agrees that:

 

  (a)

it will use the emblem of the European Union or a reference to the EU, as appropriate, in a visible way in all its press releases, communications materials, the social media, as well as in all contractual documentation directly related to the Investment;

 

  (b)

the Bank may be obliged to communicate information relating to the Guarantor and the Investment to any competent institution or body of the European Union in accordance with the relevant mandatory provisions of European Union law or pursuant to the InvestEU Regulation;

 

  (c)

the Bank and/or the European Commission may showcase this Investment by way of, among other, audio visual material or print publications and including information on the names and addresses of the Group Companies, the financing form and the sector of activity of the Investment;

 

20


  (d)

the Bank may publish in its website or produce press releases containing information related to the financing provided pursuant to this Guarantee Agreement with support under the InvestEU Fund, upon signature of the Finance Contract, the Bank may publicise on social media or produce a press release and publish on its website information relating to the financing provided pursuant to the Finance Contract, including the name, locality and country of establishment of the Guarantor, and the type of financial support received under the Finance Documents;

 

  (e)

unless the Guarantor, prior to the Borrower receiving financial support under the InvestEU Fund, declares in writing to the Bank (including by way of representation in this Guarantee Agreement) that the below publication by the Bank:

 

  (i)

risks harming its commercial interests or threatening the rights and freedoms of the persons or entities concerned as protected by the Charter of Fundamental Rights of the European Union; or

 

  (ii)

would be illegal under the laws and regulations applicable to the Guarantor,

the Bank shall annually publish on its website information on the Guarantor, which shall include the name and address of the Guarantor and the financing form of support under the InvestEU Fund; and

 

  (f)

if requested by the Bank, the Guarantor undertakes to refer to the financing and any other financing granted by the Bank or financial instrument entered into with the Bank in its public communications up to and including the Final Availability Date.

 

9.4

Confidential information. Article 10.10 (No MNPI or prohibited disclosures) of the Finance Contract shall apply mutatis mutandis to this Guarantee Agreement.

 

10

TAXES

 

10.1

Taxes

 

10.1.1

The Guarantor shall pay all Taxes, duties, fees and other impositions of whatsoever nature, including stamp duty and registration fees, arising out of the execution or implementation of each Guaranteed Document or any related document and in the creation, perfection, registration or enforcement of any security for the Loan to the extent applicable.

 

10.1.2

The Guarantor shall pay all principal, interest, indemnities and other amounts due under the Guaranteed Documents gross without any withholding or deduction of any national or local impositions whatsoever, provided that if relevant Obligor is required by law or an agreement with a governmental authority or otherwise to make any such withholding or deduction, it will gross up the payment to the Bank so that after withholding or deduction, the net amount received by the Bank is equivalent to the sum due.

 

10.2

Default interest

 

10.2.1

If the Guarantor fails to pay any amount payable by it under this Guarantee Agreement within the relevant Payment Period in accordance with Clause 2.2 (Demands and payments), interest shall accrue on any overdue amount payable under the terms of this Guarantee Agreement, as from the expiration of the relevant Payment Period up to the date of actual payment by the Guarantor at an annual rate equal to EURIBOR plus 2 per cent.

 

10.2.2

For the purpose of determining EURIBOR, the relevant periods within the meaning of Annex II (EURIBOR) shall be successive periods of one month commencing on the expiration of the Payment Period.

 

21


10.2.3

If the overdue sum is in a currency other than the currency of the Loan, the relevant interbank rate that is generally retained by the Bank for transactions in that currency plus two per cent. shall apply, calculated in accordance with the market practice for such rate.

 

10.3

Other charges. All fees (including legal fees), costs and expenses incurred as a result of the negotiation, preparation, enforcement, registration, or translation of this Guarantee Agreement shall be borne by the Guarantor.

 

11

CURRENCY CONVERSION

 

11.1

Any payment to be made by the Guarantor under this Guarantee Agreement shall be made in the currency as set out in the relevant Notification. The Bank shall apply the exchange rate published by the European Central Bank in Frankfurt for the purpose of any currency conversion.

 

11.2

If the Bank has received a payment under this Guarantee in a currency other than the currency requested in the relevant Notification and must convert this payment, the Guarantor shall indemnify the Bank, upon first demand, for any loss resulting from the difference in exchange rates between the date of conversion and the date on which the payment is received in the other currency, as well as for any fees (including legal fees, Taxes and any other charges) connected with this conversion.

 

12

NOTICES

 

12.1

Notices to each Party

 

12.1.1

Notices and other communications given under this Guarantee Agreement addressed to either Party to this Guarantee Agreement shall be made to the address or e-mail address as set out below:

For the Bank

The European Investment Bank

Attention: OPS/EGPF/2-DTLS/LSB

100 boulevard Konrad Adenauer

L-2950 Luxembourg

For the Guarantor

IO Biotech, Inc.

430 E 29th St.

Suite 940

New York, NY 10016

 

12.1.2

Each Party shall promptly notify the other Party in writing of any change in their respective communication details.

 

12.2

Form of notice

 

  (a)

Any notice or other communication given under this Guarantee Agreement must be in writing and, unless otherwise stated, may be made by letter or electronic mail.

 

  (b)

Notices and other communications for which fixed periods are laid down in this Guarantee Agreement or which themselves fix periods binding on the addressee, may be made by hand delivery, registered letter or by electronic mail. Such notices and communications shall be deemed to have been received by the other Party:

 

22


  (i)

on the date of delivery in relation to a hand-delivered or registered letter; or

 

  (ii)

in the case of any electronic mail, only when actually received in readable form and only if it is addressed in such a manner as the other Party shall specify for this purpose.

 

  (c)

Any notice provided by the Guarantor to the Bank by electronic mail shall:

 

  (i)

mention the Contract Number in the subject line; and

 

  (ii)

be in the form of a non-editable electronic image (pdf, tif or other common non-editable file format agreed between the Parties) of the notice signed by one or more Authorised Signatories of the Guarantor as appropriate, attached to the electronic mail.

 

  (d)

Notices issued by the Guarantor pursuant to any provision of this Guarantee Agreement shall, where required by the Bank, be delivered to the Bank together with satisfactory evidence of the authority of the person or persons authorised to sign such notice on behalf of the Guarantor and the authenticated specimen signature of such person or persons.

 

  (e)

Without affecting the validity of electronic mail or communication made in accordance with this Clause 12, any notice, communication or document required by the Bank shall also be sent by registered letter to the relevant party at the latest on the immediately following Business Day.

 

  (f)

The Parties agree that any above communication (including via electronic mail) is an accepted form of communication, shall constitute admissible evidence in court and shall have the same evidential value as an agreement under hand.

 

12.3

US Patriot Act. The Bank hereby notifies the Guarantor that pursuant to the requirements of the US Patriot Act, the Bank may be required to obtain, verify, and record information that identifies the Guarantor, which information includes the name and address of the Guarantor and other information that will allow the Bank to identify the Guarantor in accordance with the US Patriot Act.

 

13

TRANSFER AND CONTINUING OBLIGATIONS

 

13.1

Transfer

 

  (a)

The Bank may assign or transfer (by way of novation, sub-participation or otherwise) all or part of its rights, benefits, or obligations under this Guarantee Agreement in accordance with the provisions of the Finance Contract.

 

  (b)

The Bank shall have the right to disclose all information relating to or concerning the Guarantor, the Group, the Finance Documents, and the First Demand Guarantee in connection with or in contemplation of any such assignment or transfer.

 

  (c)

Any rights and/or obligations of the Guarantor under this Guarantee Agreement cannot be transferred or assigned in any way whatsoever to any third parties without the prior written consent of the Bank.

 

13.2

Continuing obligations. Without prejudice to the terms of this Guarantee Agreement (including, but not limited to, Clause 8.1.5 (Merger)), it is hereby expressly agreed that any change, whatsoever, in the legal situation of the Guarantor shall not affect its obligations under this Guarantee Agreement and that in particular, in case of merger, demerger or absorption, the absorbing new or beneficiary company shall take over, under the merger treaty or agreement, the commitments of the Guarantor under this Guarantee Agreement and in case of demerger, the demerger companies benefiting from the partial assignment of assets resulting from the split will be bound to:

 

  (a)

take over with joint liability the commitments of the Guarantor under this Guarantee Agreement; and

 

  (b)

if requested by the Bank, grant additional Security or guarantees.

 

23


14

SEVERABILITY

If at any time any provision of this Guarantee Agreement is or becomes illegal, invalid or unenforceable in any respect, or this Guarantee Agreement is or becomes ineffective in any respect, under the laws of any jurisdiction, such illegality, invalidity, unenforceability or ineffectiveness shall not affect:

 

  (a)

the legality, validity or enforceability in that jurisdiction of any other provision of this Guarantee Agreement or the effectiveness in any other respect of this First Demand Guarantee in that jurisdiction; or

 

  (b)

the legality, validity or enforceability in other jurisdictions of that or any other provision of this Guarantee Agreement or the effectiveness of this First Demand Guarantee under the laws of such other jurisdictions.

 

15

NO WAIVER

No failure or delay or single or partial exercise by the Bank in exercising any of its rights or remedies under this Guarantee Agreement shall be construed as a waiver of such right or remedy and the Bank shall not be liable for any such failure, delay or single or partial exercise of any such right and remedy.

 

16

SET-OFF

The Bank may set off any matured obligation due from the Guarantor under this Guarantee Agreement (to the extent beneficially owned by the Bank) against any obligation (whether or not matured) owed by the Bank to the Guarantor, regardless of the place of payment, booking branch or currency of either obligation. If the obligations are in different currencies, the Bank may convert either obligation in accordance with Clause 11 (Currency Conversion) of this Guarantee Agreement. If either obligation is unliquidated or unascertained, the Bank may set off in an amount estimated by it in good faith to be the amount of that obligation.

 

17

AMENDMENTS

Any amendment to this Guarantee Agreement shall be made in writing and shall be signed by the Parties hereto.

 

18

GOVERNING LAW AND JURISDICTION

 

18.1

Governing Law. This Guarantee Agreement shall be governed by and construed in all respects in accordance with Danish law, without regard to any principles of conflicts or choice of law in Denmark or in any other jurisdiction.

 

18.2

Jurisdiction

 

  (a)

The courts of Denmark (with the City Court of Copenhagen (in Danish: “Københavns Byret”) as the court of first instance) have exclusive jurisdiction to settle any dispute (a “Dispute”) arising out of or in connection with this Guarantee Agreement (including a dispute regarding the existence, validity or termination of this Guarantee Agreement or the consequences of its nullity) or any non-contractual obligation arising out of or in connection with this Guarantee Agreement.

 

  (b)

The Parties agree that the Courts of Denmark are the most appropriate and convenient courts to settle Disputes between them and, accordingly, that they will not argue to the contrary.

 

18.3

Place of Performance. Unless otherwise specifically agreed by the Bank in writing, the place of performance under this Guarantee Agreement, shall be the seat of the Bank.

 

24


19

ENTIRE AGREEMENT

 

19.1

The recitals and annexes form an integral part of this Guarantee Agreement.

 

19.2

The following annexes are attached to this Guarantee Agreement:

Annex I - Authorities of the signatories of the Guarantor

Annex II - EURIBOR

 

19.3

This Guarantee Agreement constitutes the entire agreement between the Bank and the Guarantor in relation to the matters set out herein, and supersedes any previous agreement, whether express or implied, on the same matter.

 

20

WAIVER OF JURY TRIAL

EACH OF THE PARTIES TO THIS GUARANTEE AGREEMENT AGREES TO WAIVE IRREVOCABLY ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM BASED UPON OR ARISING OUT OF THIS GUARANTEE AGREEMENT OR ANY OF THE DOCUMENTS REFERRED TO IN THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED IN THIS GUARANTEE AGREEMENT. This waiver is intended to apply to all Disputes. Each party acknowledges that (a) this waiver is a material inducement to enter into this Guarantee Agreement, (b) it has already relied on this waiver in entering into this Agreement and (c) it will continue to rely on this waiver in future dealings. Each party represents that it has reviewed this waiver with its legal advisers and that it knowingly and voluntarily waives its jury trial rights after consultation with its legal advisers. In the event of litigation, this Guarantee Agreement may be filed as a written consent to a trial by the court.

 

25


ANNEX I - AUTHORITIES OF THE SIGNATORIES OF THE GUARANTOR

 

Name

  

Position

  

Authority

[•]    [•]    [•]

 

26


ANNEX II - EURIBOR

EURIBOR” means:

 

  (a)

in respect of a relevant period of less than one month, the Screen Rate (as defined below) for a term of one month;

 

  (b)

in respect of a relevant period of one or more months for which a Screen Rate is available, the applicable Screen Rate for a term for the corresponding number of months; and

 

  (c)

in respect of a relevant period of more than one month for which a Screen Rate is not available, the rate resulting from a linear interpolation by reference to two Screen Rates, one of which is applicable for a period next shorter and the other for a period next longer than the length of the relevant period,

(the period for which the rate is taken or from which the rates are interpolated being the “Representative Period”).

For the purposes of paragraphs (a) to (c) above:

 

  (i)

available” means the rates, for given maturities, that are calculated and published by Global Rate Set Systems Ltd (GRSS), or such other service provider selected by the European Money Markets Institute (EMMI), or any successor to that function of EMMI, as determined by the Bank; and

 

  (ii)

Screen Rate” means the rate of interest for deposits in EUR for the relevant period as published at 11:00 a.m., Brussels time, or at a later time acceptable to the Bank on the day (the “Reset Date”) which falls 2 (two) Relevant Business Days prior to the first day of the relevant period, on Reuters page EURIBOR 01 or its successor page or, failing which, by any other means of publication chosen for this purpose by the Bank.

If such Screen Rate is not so published, the Bank shall request the principal offices of four major banks in the euro-zone, selected by the Bank, to quote the rate at which EUR deposits in a comparable amount are offered by each of them, as at approximately 11:00 a.m., Brussels time, on the Reset Date to prime banks in the euro-zone interbank market for a period equal to the Representative Period. If at least 2 (two) quotations are provided, the rate for that Reset Date will be the arithmetic mean of the quotations. If no sufficient quotations are provided as requested, the rate for that Reset Date will be the arithmetic mean of the rates quoted by major banks in the euro-zone, selected by the Bank, at approximately 11:00 a.m., Brussels time, on the day which falls 2 (two) Relevant Business Days after the Reset Date, for loans in EUR in a comparable amount to leading European banks for a period equal to the Representative Period.

The Bank shall inform the Guarantor without delay of the quotations received by the Bank.

All percentages resulting from any calculations referred to in this Schedule will be rounded, if necessary, to the nearest one thousandth of a percentage point, with halves being rounded up.

If any of the foregoing provisions becomes inconsistent with provisions adopted under the aegis of EMMI (or any successor to that function of EMMI as determined by the Bank) in respect of EURIBOR, the Bank may by notice to the Guarantor amend the provision to bring it into line with such other provisions.

If the Screen Rate becomes permanently unavailable, the EURIBOR replacement rate will be the rate (inclusive of any spreads or adjustments) formally recommended by (i) the working group on euro risk-free rates established by the European Central Bank (ECB), the Financial Services and Markets Authority (FSMA), the European Securities and Markets Authority (ESMA) and the European Commission, or (ii) the European Money Market

 

27


Institute, as the administrator of EURIBOR, or (iii) the competent authority responsible under Regulation (EU) 2016/1011 for supervising the European Money Market Institute, as the administrator of the EURIBOR, or (iv) the national competent authorities designated under Regulation (EU) 2016/1011, or (v) the European Central Bank.

If the Screen Rate becomes permanently unavailable and no EURIBOR replacement rate is formally recommended as provided above, EURIBOR shall be the rate (expressed as a percentage rate per annum) which is determined by the Bank to be the all-inclusive cost to the Bank for the funding of the relevant Tranche based upon the then applicable internally generated Bank reference rate or an alternative rate determination method reasonably determined by the Bank.

 

28


 

SIGNATURES

The parties hereto have caused this Guarantee Agreement to be executed in 3 (three) originals in the English language on the date set out in the beginning of this Guarantee Agreement.

The Guarantor

For and on behalf of IO Biotech, Inc.

 

By  

/s/ Mai-Britt Zocca

    By  

 

Name:   Mai-Britt Zocca     Name:  
Title:   Chief Executive Officer     Title:  

The Bank

For and on behalf of The European Investment Bank

By  

/s/ Maria-Teresa Massaad

    By  

/s/ Yu Zhang

Name:   Maria-Teresa Massaad     Name:   Yu Zhang
Title:   Head of Division     Title:   Head of Division

 

29

Exhibit 10.3

 

SIDE LETTER
RELATING TO AN UP TO EUR 20,000,000 ACCORDION TRANCHE

 

between

 

 

and

 

 

Dated:

 

 

IO BIOTECH APS

as Borrower

 

EUROPEAN INVESTMENT BANK

as Bank

 

19 DECEMBER 2024


SIDE LETTER TO FINANCE CONTRACT

This side letter (the “Letter”) is made on the date first stated above between:

 

1)

IO BIOTECH APS, company registration no. (CVR) 36474483, C/O COBIS, Ole Maaløes Vej 3, 2200 København N, Denmark (the “Borrower”) as borrower, and

 

2)

THE EUROPEAN INVESTMENT BANK, 100 blvd Konrad Adenauer, Luxembourg, L-2950 Luxembourg (the “Bank”) as lender.

The Bank and the Borrower together are referred to as the “Parties” and any of them is a “Party”.

 

1.

BACKGROUND

 

1.1

The Term Sheet and the Finance Contract. Reference is made to: (i) the indicative, non-binding term sheet of June 2024 related to up to EUR 57,500,000 loan facilities to finance the eligible costs incurred by the Borrower in relation to IO BIOTECH (IEU LS) (2024-0179) project (the “Term Sheet”); and (ii) the EUR 37,500,000 finance contract dated 19 December 2024 between the Borrower as borrower and the Bank as lender (the “Finance Contract”) signed in reference to the aforementioned Term Sheet.

 

1.2

This Letter. The Parties have agreed to enter into this Letter, on a non-binding basis, in order to potentially make available to the Borrower (at the Bank’s sole discretion and subject to approval by its governing bodies) an accordion facility in an amount of up to EUR 20,000,000.

 

1.3

Interpretation. The principles of interpretation set out in the Finance Contract shall have effect as if set out in this Letter.

 

2.

DEFINITIONS

In addition to the above definitions and the terms defined in the Finance Contract, the following terms shall have the following meanings when used in this Letter:

Accordion Tranche” means optional, uncommitted and additional loan tranche(s) of up to EUR 20,000,000 in aggregate that may be established pursuant to the Accordion Tranche Contract.

Accordion Tranche Contract” means: (i) an amendment letter to the Finance Contract; or, alternatively, (ii) a new (separate) finance contract (on terms to be agreed) between the Borrower as borrower and the Bank as lender, making the Accordion Tranche available to the Borrower.

Accordion Tranche Request” means a notice substantially in the form set out in Schedule 1 (Form of Accordion Tranche Request) requesting the establishment of the Accordion Tranche on the terms set out therein.

Accordion Tranche Warrants” means any warrants to be issued to the Bank in connection with disbursement of the Accordion Tranche.

 

3.

POTENTIAL ESTABLISHMENT OF ACCORDION TRANCHE

 

3.1

Accordion Tranche Request

 

 

PAGE 2


3.1.1

Provided that Tranche C has been disbursed in full, the Borrower may, on one or more occasions, notify the Bank by delivery of an Accordion Tranche Request that it wishes to establish the Accordion Tranche.

 

3.1.2

An Accordion Tranche Request shall specify the following:

 

  a)

the proposed amount of the Accordion Tranche;

 

  b)

the proposed establishment date of the Accordion Tranche;

 

  c)

the proposed interest rate;

 

  d)

the proposed Accordion Tranche maturity date;

 

  e)

the proposed Accordion Tranche availability period; and

 

  f)

the proposed number of Accordion Tranche Warrants to be issued;.

 

3.1.3

The Borrower may only submit an Accordion Tranche Request if no Default has occurred and is continuing or would occur immediately after or as a result of such proposed Accordion Tranche.

 

3.1.4

The Bank shall not be bound by the terms of the Accordion Tranche Request and may propose different terms or conditions on which the Accordion Tranche may be made available to the Borrower. In particular, the Bank may require further appraisal (due diligence) of the Borrower’s projects that will be financed from the Accordion Tranche. Such appraisal and relevant approval by the Bank’s governing bodies may therefore determine further conditions for provision of the Accordion Tranche.

 

3.2

Accordion Tranche Contract

 

3.2.1

Upon receipt of a duly completed Accordion Tranche Request, the Bank may (at its sole discretion and subject to approval by its governing bodies) decide to make available the Accordion Tranche to the Borrower.

 

3.2.2

If the Bank decides (at its sole discretion and subject to approval by its governing bodies) to make available the Accordion Tranche to the Borrower, and the Parties agree on the terms and conditions of the Accordion Tranche, the Parties shall enter into an Accordion Tranche Contract. If the Bank so requires, execution of the Accordion Tranche Contract may be preceded by conclusion of an indicative, non-binding term sheet for the Accordion Tranche.

 

4.

FEES, COSTS AND EXPENSES

Article 8 (Charges and expenses) of the Finance Contract will apply mutatis mutandis to this Letter. The Bank may require the Borrower to sign with the Bank a separate fee letter with respect to the Accordion Tranche Contract.

 

5.

MISCELLANEOUS

 

5.1

Non-binding nature. This Letter reflects the Parties’ intention to cooperate, expressed in good faith. This Letter is not intended to create rights or obligations under international or domestic law. This Letter is not a legally binding arrangement and does not represent nor does it intend to create any right or binding legal obligation or relation between the Parties. Without limitation, this Letter does not:

 

  a)

result in the establishment of any claims, financial implication, commitment, obligation or liability between the Parties;

 

 

PAGE 3


  b)

represent any commitment or representation with regard to provision of financing or funding or any form of preferential treatment of the Borrower by the Bank, in particular, but not limited to, with regard to the implementation of any projects or products or any funding or underwriting thereof on the part of either Party; or

 

  c)

affect any existing agreement or other arrangement between the Parties and does not prevent the signature of any future binding or non-binding arrangement between the Parties.

 

5.2

Approvals. Any arrangement between the Parties implementing this Letter or to which this Letter refers shall be subject to a prior approval by each Party’s decision-making bodies, to any applicable internal approvals that may be required pursuant to the respective internal policies, rules, conditions and procedures of each Party and to the agreement on, and execution of, the relevant contractual documentation.

 

5.3

Counterparts. This Letter may be executed in any number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single copy of it.

 

5.4

Law and jurisdiction. Article 10.1 (Governing law) and Article 10.2 (Jurisdiction) of the Finance Contract will apply mutatis mutandis to this Letter.

(Signature pages follow)

 

 

PAGE 4


(Signature page to side letter)

 

IO Biotech ApS    
as Borrower    

/s/ Mai-Britt Zocca

Name: Mai-Britt Zocca

   
Title: Authorised signatory    
The European Investment Bank    
as Bank    

/s/ Yu ZHANG

   

/s/ Antoine DE LACHAUX

Name: Yu ZHANG     Name: Antoine DE LACHAUX
Title: Head of Division     Title: Head of Unit

 

 

PAGE 5


SCHEDULE 1—FORM OF ACCORDION TRANCHE REQUEST

To:    The European Investment Bank (the “Bank”)

From:   IO Biotech ApS (the “Borrower”)

Date:   [ * ]

Dear Sirs/Madams,

SIDE LETTER DATED [*] 2024 (THE “SIDE LETTER”)

We refer to the Side Letter between the Bank as lender and the Borrower as borrower. This is an Accordion Tranche Request. Terms defined in the Side Letter shall have the same meaning when used in this Accordion Tranche Request.

Pursuant to Clause 3.1 (Accordion Tranche Request) of the Side Letter, we hereby request that the Bank make available to the Borrower the Accordion Tranche on the following terms:

 

a)  Proposed amount

   EUR [*]

b)  Proposed establishment date

   [*]

c)  Proposed interest rate

   [*]

d)  Proposed Accordion Tranche maturity date

   [*]

e)  Proposed Accordion Tranche availability period

   From [*] to [*]

f)   Proposed number of Accordion Tranche Warrants to be issued

   [*]

Yours faithfully

 

IO Biotech ApS    
as Borrower    

 

   

 

Name:     Name:
Title:     Title:

 

 

PAGE 6

Exhibit 10.4

Contract Number (FI No.)°97869

Serapis No.°2024-0179

EIB Internal Classification Level – Corporate Use

DATED DECEMBER 19, 2024

IO BIOTECH (IEU LS)

IO BIOTECH, INC.

as the Company

AND

THE EUROPEAN INVESTMENT BANK

as the Original Warrantholder

WARRANT ISSUANCE AGREEMENT


Contents

 

1.

 

DEFINITIONS AND INTERPRETATION

     3  

2.

 

THE WARRANTS

     18  

3.

 

ISSUANCE OF THE WARRANTS

     19  

4.

 

ANTI-DILUTION PROTECTIONS

     20  

5.

 

EVENTS

     22  

6.

 

WARRANT SETTLEMENT

     22  

7.

 

PERMITTED WARRANTHOLDER RIGHTS

     26  

8.

 

ISSUANCE OF WARRANT SHARES

     26  

9.

 

REPRESENTATIONS AND WARRANTIES

     27  

10.

 

UNDERTAKINGS

     28  

11.

 

LIQUIDATION OF THE COMPANY

     29  

12.

 

FINANCE CONTRACT

     29  

13.

 

ASSIGNMENT

     30  

14.

 

BUSINESS DAYS

     31  

15.

 

CERTIFICATES AND DETERMINATIONS

     31  

16.

 

AMENDMENT

     31  

17.

 

WAIVER

     31  

18.

 

RIGHTS AND REMEDIES ARE CUMULATIVE

     31  

19.

 

INVALIDITY

     31  

20.

 

NO PARTNERSHIP

     31  

21.

 

NOTICES

     32  

22.

 

COSTS

     33  

23.

 

TAXES, DUTIES, AND FEES; INTEREST ON OVERDUE SUMS; PAYMENTS

     34  

24.

 

EUR

     35  

25.

 

SET-OFF

     35  

26.

 

COUNTERPARTS

     35  

27.

 

FURTHER ASSURANCE

     36  

28.

 

THIRD PARTY RIGHTS

     36  

29.

 

MUTUAL DRAFTING

     36  

30.

 

ENTIRE AGREEMENT

     36  

31.

 

GOVERNING LAW; JURISDICTION; WAIVER OF TRIAL BY JURY; REMEDIES

     36  

32.

 

NO MNPI OR PROHIBITED DISCLOSURES

     37  

33.

 

TERMINATION

     38  

SCHEDULE 1 FORM OF WARRANT AGREEMENT

     41  

SCHEDULE 2 WARRANTHOLDER PUT OPTION NOTICE (THE “NOTICE”)

     42  

SCHEDULE 3 EXPERT DETERMINATION

     45  

SCHEDULE 4 CAPITALIZATION TABLE

     48  

 

- i -


EXHIBIT A CHARTER

     49  

 

- ii -


THIS WARRANT ISSUANCE AGREEMENT (this “Agreement”) is dated December 19, 2024,

BETWEEN:

 

(1)

IO Biotech, Inc., a Delaware corporation, having its registered office at c/o The Corporation Trust Company, Corporation Trust Center, 1209 N Orange Street, City of Wilmington, County of New Castle, DE 19801, and registered with the Delaware Secretary of State under file number 5924808 (the “Company”); and

 

(2)

The European Investment Bank, having its seat at 98-100 Boulevard Konrad Adenauer, L-2950 Luxembourg (the “Original Warrantholder”).

WHEREAS:

 

(A)

The Company is incorporated in the State of Delaware and is publicly listed on the Nasdaq stock exchange (NASDAQ: IOBT).

 

(B)

The Original Warrantholder has agreed to provide a loan facility to the Borrower pursuant to the Finance Contract and entry into this Agreement and, as applicable, the Warrant Agreements contemplated by this Agreement are conditions precedent to disbursement of Tranche A, Tranche B, and Tranche C under the Finance Contract.

 

(C)

The Company has agreed to issue the Permitted Warrantholder the Warrants to purchase and subscribe for shares in the Company contemplated hereby.

 

(D)

The Company has agreed to take all actions available to it and its corporate bodies (including passing all necessary Board of Directors and Shareholder and other corporate resolutions) to enable the Company to grant such rights and to issue such Shares as set out in this Agreement.

IT IS AGREED as follows:

 

1.

DEFINITIONS AND INTERPRETATION

 

1.1

In this Agreement the following words and expressions will have the following meanings, save where the context requires otherwise:

5-Day VWAP” means, on any given date, the VWAP during the five (5) Trading Days prior to such date.

Affiliate” means, in respect of any entity, another entity that directly or indirectly is in Control of, or is Controlled by, or is under common Control with that entity.

Applicable Law” means all applicable law and regulation which from time to time is binding on the Company or the Borrower.

Bank Affiliate” has the meaning set out in the Finance Contract.

 

- 3 -


Bankruptcy or Insolvency Event” means of any of the following: (i) the admission by the Company or Borrower of its inability to pay its debts when and as they become due; (ii) the execution by the Company or Borrower of a general assignment for the benefit of creditors; (iii) the filing by or against the Company or Borrower of a petition in bankruptcy or any petition for relief under any bankruptcy, insolvency, or debtor’s relief law, or, in the case of any involuntary filing of a petition against the Company or Borrower, the continuation of such petition without dismissal for a period of sixty (60) days or more; (iv) the appointment of a receiver or trustee to take possession of the property or assets of the Company or Borrower; (v) any action to liquidate, dissolve, transfer, or wind up the business of the Company or Borrower under any Applicable Law; or (vi) any other corporate action, legal proceedings or other procedure or step is taken in relation to the suspension of payments, a moratorium of any indebtedness, dissolution, administration or reorganization (by way of voluntary arrangement, scheme of arrangement or otherwise) taken with regards to the Company or Borrower under any Applicable Law.

Borrower” means IO Biotech ApS, a private limited liability company incorporated in Denmark, and a Subsidiary of the Company, having its registered office at C/O COBIS

Ole Maaløes Vej 3, 2200 København N, Denmark.

Business Day” means a day (other than a Saturday or Sunday) on which the Original Warrantholder and commercial banks are open for general business in Copenhagen, Luxembourg, and New York, New York.

Call Option” has the meaning set forth in the Warrant Agreements.

Call Option Price” has the meaning set forth in the Warrant Agreements.

Change of Control Event” means (i) any person or group of persons acting in concert gains Control of the Company or of any entity directly or ultimately Controlling the Company or (ii) the Company, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially all of its assets in one or a series of related transactions.

Charter” means, with respect to the Company, the Amended and Restated Certificate of Incorporation, filed with the Secretary of State of the State of Delaware on June 8, 2023, initially in the form attached hereto as Exhibit A (Charter), as amended or restated from time to time.

Common Stock” means the common stock of the Company, par value $0.001 per share, provided that upon the occurrence of any event whereby all of the outstanding shares of common stock of the Company are reclassified, exchanged, combined, substituted, or replaced for, into, with or by securities of a different person or securities of the Company of a different class and/or series, then from and after the consummation of such event, the term “Common Stock” shall mean such securities (and for the avoidance of doubt, such principle shall apply to successive reclassifications, exchanges, combinations, substitutions, replacements or other similar events).

Company Share Sale” means the closing of an issuance, sale, assignment, transfer or other disposal by the Company or by holders of its Instruments of 50% (fifty percent) or more of the issued and outstanding share capital in the Company or of any entity Controlling the Company or the Borrower to any person or group of persons acting in concert, provided however that a sale, assignment, transfer or other disposal by an entity Controlling the Company or the Borrower to an Affiliate of such entity shall not constitute a Company Share Sale.

 

- 4 -


Completion” means each moment in which Warrants are issued in favor of the Permitted Warrantholder, and the subscription by the Permitted Warrantholder of the Warrants.

Contract Number” means the Original Warrantholder’s generated number identifying this Agreement and indicated on the cover page of this Agreement after the letters “FI No.”

Control” means the power to direct the management and policies of an entity, whether through the ownership of voting capital, by contract or otherwise and, for the avoidance of doubt, owning more than 50% (fifty percent) of the shares of an entity would constitute Control, and “Controlling” has the corresponding meaning.

Convertible Securities” means any securities (directly or indirectly) convertible into or exercisable or exchangeable for Common Stock, but excluding Options.

Credit” has the meaning set out in the Finance Contract.

Debt Repayment Event” means (i) a prepayment or repayment of the entire principal amount due in respect of a Loan, whether on a voluntary or mandatory basis or (ii) an event (other than an Event of Default) which entitles the Permitted Warrantholder to demand the prepayment or repayment of the entire principal amount due in respect of a Loan, which, for the avoidance of doubt, includes the Maturity Date of such Loan.

Directors” or “Board of Directors” means the directors or the board of directors of the Company from time to time.

Disbursement Date” has the meaning set out in the Finance Contract.

Disbursement Offer” has the meaning set out in the Finance Contract.

Disclosure Document” has the meaning ascribed to it in Clause 3.1(c) (Steps with Respect to Execution of this Agreement).

Encumbrance” means any encumbrance, debenture, mortgage, blocking order, court decision, court order, leases, subleases, preliminary agreements on the conclusion of subleases, arrest, execution order, order preventing the sale of any assets, charge, pledge, lien, restriction, assignment, hypothecation, security interest, title retention or any other agreement or arrangement the effect of which is the creation of security, or any other interest, equity or other right of any person (including any right to acquire, option, right of first refusal or right of pre-emption), or any agreement or arrangement to create any of the same.

EUR” or “euro” means the lawful currency of the Member States of the European Union which adopt or have adopted it as their currency in accordance with the relevant provisions of the Treaty on European Union and the Treaty on the Functioning of the European Union or their succeeding treaties.

EURIBOR” has the meaning given to it in the Finance Contract.

 

- 5 -


Event” means:

 

  (a)

a Sale;

 

  (b)

a Change of Control Event;

 

  (c)

a Debt Repayment Event;

 

  (d)

the consummation of the transactions contemplated by a Qualifying Tender Offer;

 

  (e)

the service by the Permitted Warrantholder on the Company of an Event of Default Notice (for the avoidance of doubt, regardless of whether the Permitted Warrantholder opts to demand the prepayment or repayment of any principal amount due in respect of the Loan in connection with the relevant Event of Default);

 

  (f)

a de-listing of the Company’s Shares or removal from the exchange on which the Company’s Shares trade, unless immediately after such event the Company’s Shares will be listed or quoted for trading on any of the following Trading Markets: NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange (or any successors to any of the foregoing).

 

  (g)

an event of voluntary or involuntary liquidation, dissolution, or winding-up of the Company, in accordance with the Charter.

Event Date” means the date on which any Event occurs, being the first of:

 

  (a)

the date on which an agreement or agreements (including a promissory agreement or agreements or any other binding contractual arrangement having a similar effect) for a Sale become or becomes unconditional in all respects;

 

  (b)

the date on which a Change of Control Event occurs;

 

  (c)

the date on which a Debt Repayment Event occurs;

 

  (d)

the date on which the transactions contemplated by a Qualifying Tender Offer are consummated;

 

  (e)

the date on which service by the Permitted Warrantholder on the Company of an Event of Default Notice occurs;

 

  (f)

the date on which the Company’s Shares are de-listed or are removed from the exchange on which the Company’s Shares trade, unless immediately after such event the Company’s Shares will be listed or quoted for trading on any of the following Trading Markets: NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange (or any successors to any of the foregoing); or

 

  (g)

the date on which an event of voluntary or involuntary liquidation, dissolution, or winding-up of the Company occurs, in accordance with the Charter.

 

- 6 -


Event Notification” means a written notice from the Company to the Permitted Warrantholder informing it of the occurrence of an Event or that it reasonably anticipates an Event is reasonably likely to occur, which sets out:

 

  (a)

details of the Event or anticipated Event;

 

  (b)

the Event Date or, in respect of an anticipated Event, the expected Event Date; and

 

  (c)

such other information related to the Event that is available to the Company which is or might reasonably be considered to be material to the Permitted Warrantholder, including all such information as may reasonably be required by the Permitted Warrantholder in order for the Permitted Warrantholder to calculate Fair Market Value.

Event of Default” has the meaning set out in the Finance Contract.

Event of Default Notice” means a written notice by the Permitted Warrantholder noting the occurrence of an Event of Default under and as defined in the Finance Contract.

Exchange Act” means the Securities Exchange Act of 1934, as amended, and all of the rules and regulations promulgated thereunder.

Excluded Issuance” means an issuance or sale by the Company after the date of the Tranche A Warrant Agreement, Tranche B Warrant Agreement or Tranche C Warrant Agreement (except in the case of Clauses (e) and (g) below, which shall apply following the date specified therein) of:

 

  (a)

Shares of Common Stock (including Shares of Common Stock underlying Options or Convertible Securities) that are issued from and after the date of the Finance Contract for an aggregate value of no more than USD 300,000,000 and for which the underlying or implied price per Share is equal to or greater than 90% of the Strike Price as of the date of such issuance;

 

  (b)

Shares of Common Stock (including Shares of Common Stock underlying Options or Convertible Securities) that are issued in connection with any research, collaboration, commercialization, technology license, development, marketing, manufacturing, or other similar agreements or strategic partnerships;

 

  (c)

Shares of Common Stock issuable upon the exercise of any Warrant Agreement, or any Shares of Common Stock (including Shares of Common Stock underlying Options or Convertible Securities) that are issued for the purpose of financing the purchase of any Warrant Agreement by the Company;

 

  (d)

Shares of Common Stock (including Shares of Common Stock underlying Options or Convertible Securities) for which the purchase price (including the underlying or implied price) per Share is equal to or greater than, three times the highest Strike Price under any effective Warrant Agreement;

 

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  (e)

with respect to the Warrants applicable to each Tranche, the issuance of Shares of Common Stock (including Shares of Common Stock underlying Options or Convertible Securities) (i) following the Maturity Date of such Tranche and (ii) following the Permitted Warrantholder declining an offer by the Company, made no less than 5 (five) Trading Days after any Material Press Release, to repurchase such Warrants from the Permitted Warrantholder at a price no less than the greater of (A) zero point three (0.3) times the amount disbursed for such Tranche pursuant to the Finance Contract and (B) the positive difference of (i) 5-Day VWAP ending on and including the date of such offer multiplied by the number of Warrant Shares purchasable under the Warrant Agreement applicable to such Warrants, minus (ii) the aggregate Strike Price to exercise such Warrants;

 

  (f)

Shares of Common Stock (including Shares of Common Stock underlying Options or Convertible Securities) to directors, officers, employees or consultants of the Company in connection with their service as directors of the Company, their employment by the Company or their retention as consultants by the Company, pursuant to the Company’s 2021 Equity and Incentive Plan, 2021 Employee Stock Purchase Plan, 2023 Inducement Award Plan, or a similar equity compensation program or arrangement approved by the Board of Directors or the compensation committee of the Board of Directors, each as may be amended from time to time;

 

  (g)

Shares of Common Stock upon the conversion or exercise of Options or Convertible Securities issued prior to the date of the Finance Contract, provided that neither the conversion price or exercise price is decreased, nor the number of shares issuable under such Options or Convertible Securities is increased, in either case, after the date of the Finance Contract, other than pursuant to the provisions of such Options or Convertible Securities as they exist as of the date of the Finance Contract; or

 

  (h)

Shares of Common Stock (including Shares of Common Stock underlying Options or Convertible Securities) which is not covered by paragraphs (a)-(g) above that the Company and the Permitted Warrantholder mutually agree to treat as an Excluded Issuance.

Expert” means a reputable independent expert appointed in accordance with Schedule 3 (Expert Determination).

Expert’s Certificate” has the meaning set out in Schedule 3 (Expert Determination).

Fair Market Value means, (i) with respect to the Put Option, on the date of the Warrantholder Put Option Notice and (ii) in any other event, on the applicable date of valuation, the value of a Warrant Share as determined in accordance with the valuation principles set out in paragraph 3 (Basis of Valuation) of Schedule 3 (Expert Determination) (for the avoidance of doubt, such principles will apply regardless of whether the valuation is being determined by the Permitted Warrantholder, the Company, or the Expert as contemplated by any provision of this Agreement).

 

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Finance Contract” means the Finance Contract (governed by Danish law) dated on or about December 19, 2024, by and between the Borrower and the Original Warrantholder, as lender, pursuant to which a loan facility of up to EUR 37,500,000 (thirty-seven million and five hundred thousand euros) guaranteed by the Guarantors, is made available, as such finance contract may be amended from time to time.

Fully Diluted Share Capital” means, as at the relevant date, the aggregate of all Instruments.

Governing Law” means the laws of the State of New York.

Group” means the Group Companies, taken as a whole.

Group Asset Sale” means the closing of the sale, assignment, transfer or other disposal of all or substantially all of the assets of the Group.

Group Company” means the Company and its Subsidiaries.

Guarantor” means the Company, and each Material Subsidiary (as such term is defined in the Finance Contract) which enters into a Guarantee Agreement in accordance with the terms of the Finance Contract, allowing the Borrower to fulfil its undertaking under the terms of the Finance Contract.

Instruments” means:

 

  (a)

all issued and outstanding Shares;

 

  (b)

all Shares capable of being issued by the Company pursuant to the exercise in full of all outstanding rights (whether or not contingent and assuming full performance of any equity-linked or performance-linked rights or instruments) to subscribe for or convert into Shares (including under this Agreement); and

 

  (c)

all other issued shares, convertible securities, options, warrants, restricted stock units (RSUs), participation rights, conversion privileges or other rights or instruments which are granted to purchase, subscribe for, convert into or otherwise acquire any shares of the Company.

Lead Organization” means the European Union, the United Nations and international standard setting organizations including the International Monetary Fund, the Financial Stability Board, the Financial Action Task Force, the Organization for Economic Cooperation and Development and the Global Forum on Transparency and Exchange of Information for Tax Purposes and any successor organizations.

Loan” has the meaning set out in the Finance Contract.

Material Press Release” has the meaning set out in the Finance Contract.

Maturity Date” has the meaning set out in the Finance Contract.

MNPI” has the meaning ascribed to it in Clause 32.3 (No MNPI or Prohibited Disclosures).

Objection Period” means fifteen (15) Business Days from delivery of the draft Warrantholder Put Option Notice.

 

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New Issuance” has the meaning ascribed to it in Clause 4.1 (Adjustment to the Number of Warrant Shares Upon Issuance of Common Stock).

Opt-out Notice” has the meaning ascribed to it in Clause 32.4 (No MNPI or Prohibited Disclosures).

Organizational Documents” means, with respect to any particular entity, (i) if a corporation, the articles or certificate of incorporation and the by-laws; (ii) if a limited liability company, the articles of organization or certificate of formation and operating agreement or limited liability company agreement; (iii) if another type of entity, any other charter declaration of trust or similar document adopted or filed in connection with the creation, formation or organization of the entity; (iv) all equityholders’ agreements, voting agreements, voting trust agreements, joint venture agreements, subscription agreements, shareholders’ agreements, investor rights agreements, first refusal agreements, right of first refusal and co-sale agreements, registration rights agreements, lockup agreements, or other agreements or documents relating to the organization, management, or operation of any entity or relating to the rights, duties, and obligations of the equityholders of any entity; and (v) any amendment or supplement to any of the foregoing, including any side letter agreements or other similar agreements entered into with one or more parties to any of the foregoing documents which purport to modify or vary the terms thereof or grant additional rights to such persons.

Options” means any warrants or other rights or options to subscribe for or purchase Common Stock or Convertible Securities.

OS” means overall survival.

Party” means a party to this Agreement.

Permitted Warrantholder” means:

 

  (a)

the Original Warrantholder; and

 

  (b)

any other person that receives Warrants in connection with a Warrant Sale and joins this Agreement in accordance with Clause 6.1(f),

and only for so long as each of the foregoing holds any Warrant or a right (contingent or otherwise) to receive any additional Warrants pursuant to the terms of this Agreement.

PFS” means progression-free survival.

Purpose” has the meaning ascribed to it in Clause 32.5 (No MNPI or Prohibited Disclosures).

Put Option” means the right, but not the obligation of the Permitted Warrantholder (or an Affiliate of the Permitted Warrantholder) to require the Company or the Company’s nominee (provided that such nominee is acceptable to the Permitted Warrantholder from a KYC/AML, Sanctions, Non-Compliant Jurisdiction or Restricted Jurisdiction perspective) to cancel or purchase any Warrant (or any portion of any Warrant) in consideration of the payment by the Company or the Company’s nominee, as the case may be, to the Permitted Warrantholder of the Put Option Price in accordance with the terms of Clause 6.2 (Put Option).

 

- 10 -


Put Option Price” means the fee payable in cash by the Company or the Company’s nominee to the Permitted Warrantholder following the delivery of the Warrantholder Put Option Notice, being (a) with respect to a Put Option exercised in connection with a Qualifying Tender Offer, an amount equal to (i) the product of (1) the price per Share of Common Stock being offered by the applicable offeror multiplied by (2) the number of Warrant Shares purchasable with respect to the portion of the Warrants for which the Put Option is being exercised as of such date minus (ii) the aggregate Strike Price payable to the Company to the portion of the Warrants for which the Put Option is being exercised as of such date, and (b) otherwise an amount equal to the positive difference of (i) the aggregate Fair Market Value of the Warrant Shares purchasable with respect to the Warrants subject to the Put Option as of the date that the Warrantholder Put Option Notice is delivered pursuant to Clause 6.2 (Put Option) minus (ii) the aggregate Strike Price payable to the Company to exercise such Warrants for such Warrant Shares as of such date.

Qualifying Tender Offer” means any, direct or indirect, purchase offer, tender offer or exchange offer (whether by the Company or another person) pursuant to which all holders of Shares of Common Stock are permitted to sell, tender or exchange all of their Shares for other securities, cash or property, which has been accepted by the holders of 50% or more of the outstanding Shares of Common Stock or 50% or more of the voting power of the Common Stock.

Registration Rights Agreement” means the registration rights agreement contemplating the registration for resale of any shares of Common Stock purchased by the Permitted Warrantholder pursuant to the Warrant Agreement, to be entered into by and between the Company and the Permitted Warrantholder, in form and substance satisfactory to the Permitted Warrantholder.

Right of First Refusal” means the right (but not the obligation) of the Company to require the Permitted Warrantholder to transfer all (but not part of) the Warrants stated in the Right of First Refusal Notice to the Company in accordance with Clause 6.1 (Warrant Sale and Right of First Refusal).

Right of First Refusal Notice” means a written notice served by the Permitted Warrantholder on the Company stating that the Permitted Warrantholder wishes to sell one or more Warrants and identifying the proposed purchaser of such Warrants.

Sale” means:

 

  (a)

a Group Asset Sale; or

 

  (b)

a Company Share Sale.

SEC” means the United States Securities and Exchange Commission.

Shareholder” means any person or entity holding, at any time, Shares.

 

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Shares” means the issued shares of any class of capital stock of the Company or, as applicable, shares of any class of capital stock of the Company to be issued, at any given point in time.

Strike Price” has the meaning ascribed to it in Clause 2.2(c) (Warrant and Warrant Share Features).

Subsidiary” means an entity of which a person has direct or indirect control or owns directly or indirectly more than 50% (fifty percent) of the voting capital or similar right of ownership and “control” for this purpose means the power to direct the management and the policies of the entity, whether through the ownership of voting capital, by contract or otherwise.

Supporting Calculations” means the basis of calculation, assumptions, and working papers used to determine Fair Market Value.

Termination Date” has the meaning set out in the Warrant Agreements.

Trading Day” means a day on which the principal Trading Market is open for trading.

Trading Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on the date in question: the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange, OTCQB, OTCQX or Pink Open Market (or any successors to any of the foregoing).

Tranche” has the meaning set out in the Finance Contract.

Tranche A” has the meaning set out in the Finance Contract.

Tranche A Warrants” means warrants to purchase a number of Warrant Shares (subject to adjustment in accordance with Clause 4 (Anti-Dilution Protections) and the anti-dilution provisions set forth in the Tranche A Warrant Agreement) under the Tranche A Warrant Agreement, being issued as a condition precedent to the disbursement of Tranche A under the Finance Contract, which shall be computed using the following formula:

X = 10,000,000 / (SPa * 2)

where:    X = the number of Warrant Shares purchasable under the Tranche A Warrant Agreement.

SPa = The 5-Day VWAP per Share of Common Stock as of the date of issuance of the Tranche A Warrants.

Tranche A Warrant Agreement” means a warrant agreement issued pursuant to Clause 3 (Issuance of the Warrants) substantially in the form set out in Schedule 1 (Form of Warrant Agreement) contemplating the Tranche A Warrants.

Tranche A Warrant Issuance” has the meaning ascribed to it in Clause 3.2(a)(i) (Steps at each Completion).

 

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Tranche B” has the meaning set out in the Finance Contract.

Tranche B Warrants” means warrants to purchase a number of Warrant Shares (subject to adjustment in accordance with Clause 4 (Anti-Dilution Protections) and the anti-dilution provisions set forth in the Tranche B Warrant Agreement), being issued as a condition precedent to the disbursement of Tranche B under the Finance Contract, which:

 

  (a)

In the event that a drawdown of Tranche B occurs following the date of a positive phase III study in first line advanced melanoma study with IO102-IO103 on the full population of the study (i.e., achieve statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm), shall be computed using the following formula:

 

  (i)

if PFS for exploratory arm is greater than 12 (twelve) months:

X = 12,500,000 / (SPb * 4)

 

  (ii)

if PFS for exploratory arm is equal to or between 9.1 (nine point one) and 12 (twelve) months:

X = 12,500,000 / (SPb * 3)

 

  (iii)

if PFS for exploratory arm is below 9.1 (nine point one) months:

X = 12,500,000 / (SPb * 2.5)

 

  (b)

In the event that a drawdown of Tranche B occurs and the scenarios set forth in clause (a) above does not apply, shall be computed using the following formula:

X = 12,500,000 / (SPb * 2.25)

where:    X = the number of Warrant Shares purchasable under the Tranche B Warrant Agreement.

SPb = The 5-Day VWAP per Share of Common Stock as of the date of issuance of the Tranche B Warrants.

Tranche B Warrant Agreement” means a warrant agreement issued pursuant to Clause 3 (Issuance of the Warrants) substantially in the form set out in Schedule 1 (Form of Warrant Agreement) contemplating the Tranche B Warrants.

Tranche B Warrant Issuance” has the meaning ascribed to it in Clause 3.2(b)(i) (Steps at each Completion).

Tranche C” has the meaning set out in the Finance Contract.

Tranche C Warrants” means warrants to purchase a number of Warrant Shares (subject to adjustment in accordance with Clause 4 (Anti-Dilution Protections) and the anti-dilution provisions set forth in the Tranche C Warrant Agreement), being issued as a condition precedent to the disbursement of Tranche C under the Finance Contract, which

 

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  (a)

In the event that the cash injection to the Company between the date of the Finance Contract and the date of disbursement of Tranche C is at least $150,000,000, shall be computed using the following formula:

 

  (i)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is greater than 12 (twelve) months:

X = 15,000,000 / (SPc * 6.25)

 

  (ii)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is equal to or between 9.1 (nine point one) and 12 (twelve) months:

X = 15,000,000 / (SPc * 5.5)

 

  (iii)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is below 9.1 (nine point one) months:

X = 15,000,000 / (SPc * 4.75)

 

  (b)

In the event that the cash injection to the Company between the date of the Finance Contract and the date of disbursement of Tranche C is at least $100,000,000 but lower than $150,000,000, shall be computed using the following formula:

 

  (i)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is greater than 12 (twelve) months:

X = 15,000,000 / (SPc * 5.25)

 

  (ii)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is equal to or between 9.1 (nine point one) and 12 (twelve) months:

X = 15,000,000 / (SPc * 4.5)

 

  (iii)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is below 9.1 (nine point one) months:

X = 15,000,000 / (SPc * 3.75)

 

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  (c)

In the event that a drawdown of Tranche C occurs and the scenarios set forth in clause (a) or (b) above do not apply:

 

  (i)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is greater than 12 (twelve) months:

X = 15,000,000 / (SPc * 4.5)

 

  (ii)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is equal to or between 9.1 (nine point one) and 12 (twelve) months:

X = 15,000,000 / (SPc * 3.75)

 

  (iii)

if the phase III study in first line advanced melanoma with IO102-IO103 achieves statistical significance on PFS with a P value of 0.05 or lower with no degradation of OS trend in the exploratory arm, where the PFS for exploratory arm is below 9.1 (nine point one) months:

X = 15,000,000 / (SPc * 3)

where:    X = the number of Warrant Shares purchasable under the Tranche C Warrant Agreement.

SPc = The 5-Day VWAP per Share of Common Stock as of the date of issuance of the Tranche C Warrants.

Tranche C Warrant Agreement” means a warrant agreement issued pursuant to Clause 3 (Issuance of the Warrants) substantially in the form set out in Schedule 1 (Form of Warrant Agreement) contemplating the Tranche C Warrants.

Tranche C Warrant Issuance” has the meaning ascribed to it in Clause 3.2(c)(i) (Steps at each Completion).

Transaction Documents” means this Agreement, the Warrant Agreements, the Registration Rights Agreement and any other documents contemplated by each such agreement.

USD” or “$” means United States Dollars, the lawful currency of the United States of America.

VWAP” means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed or quoted on a Trading Market other than OTCQB or OTCQX, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on a Trading Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b) if the foregoing clause (a) is not applicable and the Common Stock is then listed on

 

- 15 -


OTCQB or OTCQX, the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable, or (c) if the foregoing clauses (a) and (b) are not applicable and if prices for the Common Stock are then reported on the Pink Open Market (or a similar organization or agency succeeding to its functions of reporting prices), the most recent bid price per Share of the Common Stock so reported, or (d) in all other cases, the value of a share of Common Stock as determined by an Expert in accordance with Schedule 3.

Warrant Agreements” means the Tranche A Warrant Agreement, Tranche B Warrant Agreement, and Tranche C Warrant Agreement, duly issued by the Company and registered on its books and records, representing the Warrants issued pursuant to Clause 3 (Issuance of the Warrants), in each case substantially in the form set out in Schedule 1 (Form of Warrant Agreement).

Warrant Sale” means, in relation to any Warrant:

 

  (a)

a sale, assignment, transfer, or other disposal of that Warrant by the Permitted Warrantholder to any person or persons selected by the Permitted Warrantholder in accordance with and as contemplated by Clause 6.1 (Warrant Sale and Right of First Refusal); or

 

  (b)

the exercise of that Warrant by the Permitted Warrantholder where the Permitted Warrantholder nominates a person (other than the Permitted Warrantholder, one of its Affiliates, or an agent mandated to hold Warrants on behalf of the Permitted Warrantholder) to whom the corresponding Warrant Share is to be directly issued.

Warrant Share” means each share of Common Stock to be issued upon the exercise of a Warrant.

Warrantholder Put Option Notice” means a put option notice served by the Permitted Warrantholder on the Company in substantially the form set out in Schedule 2 (Warrantholder Put Option Notice).

Warrants” means the Tranche A Warrants, Tranche B Warrants and the Tranche C Warrants and shall in each case include the right (but not the obligation) to subscribe for Warrant Shares, pursuant to the terms of the Warrant Agreements and subject to the terms of this Agreement.

Warrant Sale Price” has the meaning ascribed to it in Clause 6.1(a) (Warrant Sale and Right of First Refusal).

 

1.2

Interpretation

Unless a contrary indication appears, a reference in this Agreement:

 

  (a)

to this Agreement or any other agreement or instrument is a reference to this Agreement or other agreement or instrument as amended, novated, supplemented, extended or restated at any time;

 

  (b)

to Clause, paragraph or schedule is, unless stated otherwise, a reference to a Clause or paragraph of, or schedule to, this Agreement;

 

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  (c)

in a Clause or schedule to a paragraph is, unless otherwise stated, a reference to a paragraph in that Clause or schedule, where that schedule is split into parts, a reference to a paragraph in that part of that schedule;

 

  (d)

to a statute or statutory provision includes a reference to any subordinate legislation and is a reference to:

 

  (i)

that statute, statutory provision or subordinate legislation as modified, consolidated, superseded, re-enacted, re-numbered, or replaced (whether with or without modification) from time to time after the date of this Agreement; and

 

  (ii)

any statute, statutory provision or subordinate legislation which it consolidates, supersedes, re-enacts or replaces (whether with or without modification);

 

  (e)

to a “person” includes any individual, company, corporation, firm, partnership, joint venture, association, state, state agency, institution, foundation or trust (whether or not having a separate legal personality);

 

  (f)

to a Party will be deemed to be a reference to any successor to such Party or to any person or persons to whom that Party assigns or otherwise transfers any or its rights or obligations under this Agreement in accordance with this Agreement;

 

  (g)

to the Permitted Warrantholder in the context of any Warrant or related Warrant Share means the person or persons within the definition of “Permitted Warrantholder” who at that time holds or hold that Warrant;

 

  (h)

to one gender is a reference to all or any genders, and references to the singular include the plural and vice versa;

 

  (i)

to a legal term for a legal document, court, judicial process, action, remedy, legal status, official or any other legal concept or thing which is specific to a particular jurisdiction shall, in respect of any other jurisdiction, be deemed to be a reference to whatever most closely equates to that legal term in the relevant jurisdiction;

 

  (j)

or” is not exclusive; and

 

  (k)

to “including” or “includes” does not limit the scope of the meaning of the words preceding it but shall be taken as meaning “including without limitation” or “includes without limitation.

 

1.3

The schedules form part of this Agreement and a reference to “this Agreement” includes its schedules.

 

1.4

The recitals, index and headings in this Agreement do not affect its interpretation.

 

1.5

Capitalized terms used but not otherwise defined in this Agreement have the meaning ascribed to such term in the Finance Contract.

 

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2.

THE WARRANTS

 

2.1

Warrant Entitlement. The Warrants shall entitle the Permitted Warrantholder to subscribe for such number of Warrant Shares representing:

 

  (a)

for Tranche A, the Tranche A Warrants, which shall be exercisable by the Permitted Warrantholder at any time following the Disbursement Date of Tranche A under the Finance Contract;

 

  (b)

for Tranche B, the Tranche B Warrants, which shall be exercisable by the Permitted Warrantholder at any time following the Disbursement Date of Tranche B under the Finance Contract; and

 

  (c)

for Tranche C, the Tranche C Warrants, which shall be exercisable by the Permitted Warrantholder at any time following the Disbursement Date of Tranche C under the Finance Contract.

 

2.2

Warrant and Warrant Share Features. The Warrants represented by the Warrant Agreements and the Warrant Shares issued in connection with the exercise of the Warrants, shall each be issued free from Encumbrances (other than those imposed by the Permitted Warrantholder or restrictions on transfer under generally applicable securities laws) including but not limited to any pre-emptive or anti-dilution rights of the Shareholders or any other person. The execution by the Company and delivery to the Permitted Warrantholder of the relevant Warrant Agreement in accordance with this Agreement shall be no earlier than the date falling 15 (fifteen) Business Days, and no later than the date falling 10 (ten) Business Days, before the Disbursement Date for the applicable Tranche, and in any event at least 5 (five) Trading Days after any Material Press Release. Further, the Warrants represented by this Agreement shall:

 

  (a)

be issued to the Permitted Warrantholder for no additional consideration;

 

  (b)

entitle the Permitted Warrantholder to the number of Warrant Shares calculated in accordance herewith (subject to adjustment in accordance with Clause 4 (Anti-Dilution Protections) and the anti-dilution provisions set forth in the Warrant Agreements);

 

  (c)

be exercisable, on the terms of and subject to the conditions set out in this Agreement and the Warrant Agreements, against payment of a price initially equal to the greater of (x) 5-Day VWAP on the date of the execution of the applicable Warrant Agreement and (y) the applicable “Minimum Price” as defined in Nasdaq Rule 5635(d), as may be thereafter adjusted in accordance with the terms of such Warrant Agreement or Clause 4 (Anti-Dilution Protections) (the “Strike Price”);

 

  (d)

have a term of 20 (twenty) years; and

 

  (e)

be detachable from the Loan.

 

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3.

ISSUANCE OF THE WARRANTS

 

3.1

Steps with Respect to Execution of this Agreement.

 

  (a)

Before the execution of this Agreement, the Board of Directors or an authorized committee thereof, must approve, in form and substance satisfactory to the Permitted Warrantholder, a set of resolutions, which resolve, among other matters, to approve the terms of, and the transactions contemplated by, this Agreement, including to execute the Transaction Documents and issue the Warrants to the Permitted Warrantholder.

 

  (b)

Upon execution of this Agreement, the Company and the Permitted Warrantholder shall execute the Registration Rights Agreement.

 

  (c)

The Company shall, within four Business Days of the date hereof, file with the SEC a Current Report on Form 8-K (the “Disclosure Document”) disclosing all material terms of the transactions contemplated hereby, by the other Transaction Documents and the Finance Contract. Upon the issuance of the Disclosure Document, to the knowledge of the Company, the Permitted Warrantholder shall not be in possession of any material, non-public information received from the Company or any of its officers, directors, or employees or agents, that is not disclosed in the Disclosure Document unless otherwise specifically agreed in writing by the Permitted Warrantholder.

 

3.2

Steps at each Completion.

 

  (a)

With respect to Tranche A:

 

  (i)

Prior to a Disbursement Offer being made in relation to the disbursement of Tranche A, the Company shall issue to the Permitted Warrantholder the Tranche A Warrants by the execution and delivery by the Company and the Permitted Warrantholder of duly executed signature pages to the Tranche A Warrant Agreement through the exchange of electronic counterpart signature pages (the “Tranche A Warrant Issuance”). The Tranche A Warrant Issuance shall occur no earlier than the date falling 15 (fifteen) Business Days, and no later than the date falling 10 (ten) Business Days, before the Disbursement Date of Tranche A, and in any event at least 5 (five) Trading Days after any Material Press Release, exercisable on the terms and subject to the conditions set out in this Agreement and the Tranche A Warrant Agreement and which shall entitle the Permitted Warrantholder to subscribe for the Tranche A Warrants.

 

  (ii)

Prior to, or promptly following the Tranche A Warrant Issuance, the Company shall deliver two wet-ink original copies of its signature page to the Tranche A Warrant Agreement to the Permitted Warrantholder.

 

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  (b)

With respect to Tranche B:

 

  (i)

Prior to a Disbursement Offer being made in relation to the disbursement of Tranche B, the Company shall issue to the Permitted Warrantholder the Tranche B Warrants by the execution and delivery by the Company and the Permitted Warrantholder of duly executed signature pages to the Tranche B Warrant Agreement through the exchange of electronic counterpart signature pages (the “Tranche B Warrant Issuance”). The Tranche B Warrant Issuance shall occur no earlier than the date falling 15 (fifteen) Business Days, and no later than the date falling 10 (ten) Business Days, before the Disbursement Date of Tranche B, and in any event at least 5 (five) Trading Days after any Material Press Release, exercisable on the terms and subject to the conditions set out in this Agreement and the Tranche B Warrant Agreement and which shall entitle the Permitted Warrantholder to subscribe for the Tranche B Warrants; and

 

  (ii)

Prior to, or promptly following the Tranche B Warrant Issuance, the Company shall deliver two wet-ink original copies of its signature page to the Tranche B Warrant Agreement to the Permitted Warrantholder.

 

  (c)

With respect to Tranche C:

 

  (i)

Prior to a Disbursement Offer being made in relation to the disbursement of Tranche C, the Company shall issue to the Permitted Warrantholder the Tranche C Warrants by the execution and delivery by the Company and the Permitted Warrantholder of duly executed signature pages to the Tranche C Warrant Agreement through the exchange of electronic counterpart signature pages (the “Tranche C Warrant Issuance”). The Tranche C Warrant Issuance shall occur no earlier than the date falling 15 (fifteen) Business Days, and no later than the date falling 10 (ten) Business Days, before the Disbursement Date of Tranche A, and in any event at least 5 (five) Trading Days after any Material Press Release, exercisable on the terms and subject to the conditions set out in this Agreement and the Tranche C Warrant Agreement and which shall entitle the Permitted Warrantholder to subscribe for the Tranche C Warrants; and

 

  (ii)

Prior to, or promptly following the Tranche C Warrant Issuance, the Company shall deliver two wet-ink original copies of its signature page to the Tranche C Warrant Agreement to the Permitted Warrantholder.

 

4.

ANTI-DILUTION PROTECTIONS

 

4.1

Adjustment to the Number of Warrant Shares Upon Issuance of Common Stock. Except as provided in Clause 4.3 (Exceptions to Adjustment Upon Issuance of Common Stock), and except in the case of an event described in Section 3(a) of the Warrant Agreements (Stock Dividends; Splits; Combinations; Reclassifications), if the Company shall, at any time or from time to time after the execution of the Tranche A Warrant Agreement, Tranche B Warrant Agreement, or Tranche C Warrant Agreement, issue or sell, any Common Stock other than in the case of an Excluded Issuance applicable to such Warrant Agreement (a “New Issuance”), then immediately upon such New Issuance, the number of Warrant Shares issuable upon full exercise of such Warrant Agreement immediately prior to any such issuance or sale shall be increased to an amount equal to the product of:

 

- 20 -


  (a)

the quotient of (A) the number of Warrant Shares issuable upon full exercise of such Warrant Agreement immediately prior to any such issuance or sale, divided by (B) the total number of Shares of Common Stock issued and outstanding immediately prior to such issuance or sale, multiplied by:

 

  (b)

the total number of Shares of Common Stock issued outstanding immediately after such issuance or sale.

 

4.2

Adjustment to the Strike Price. Upon any adjustment of the number of Warrant Shares issuable upon full exercise of a Warrant Agreement pursuant to Clause 4.1 (Adjustment to the Number of Warrant Shares Upon Issuance of Common Stock), the Strike Price shall be decreased proportionate to the proportional increase in such number of Warrant Shares, such that after any such adjustment the aggregate Strike Price payable for the full exercise of such Warrant Agreement shall be the same as the aggregate Strike Price for the full exercise of such Warrant Agreement in effect immediately prior to such adjustment.

 

4.3

Exceptions to Adjustment Upon Issuance of Common Stock. For the avoidance of doubt, and anything herein to the contrary notwithstanding, there shall be no adjustment to the Strike Price or the number of Warrant Shares issuable upon exercise of a Warrant Agreement with respect to any Excluded Issuance applicable to such Warrant Agreement.

 

4.4

Treasury Shares. The number of Shares of Common Stock issued and outstanding at any given time shall not include Shares of Common Stock owned or held by or for the account of the Company or any of its wholly-owned subsidiaries, and the disposition of any such Shares of Common Stock (other than the cancellation or retirement thereof or the transfer of such Shares among the Company and its wholly-owned subsidiaries) shall be considered an issue or sale of Shares of Common Stock for the purpose of this Clause 4 (Anti-Dilution Protections).

 

4.5

Adjustments and New Warrant Issuance.

 

  (a)

Adjustments. Upon the occurrence of any adjustment pursuant to this Clause 4 (Anti-Dilution Protections) with respect to a Warrant Agreement, the Company at its expense shall promptly (and, in any event, within five (5) Business Days) deliver to the Permitted Warrantholder a written notice describing in reasonable detail the adjustment, including a statement of the adjusted Strike Price and adjusted number of Warrant Shares, the transactions giving rise to such adjustments and the facts upon which such adjustment is based. The Company shall, upon written request from the Permitted Warrantholder, furnish the Permitted Warrantholder with a certificate of its Chief Financial Officer or Chief Executive Officer, including computations of such adjustment and the Strike Price, class, and number of Shares in effect upon the date of such adjustment.

 

  (b)

Issuance of New Warrant Agreement. Upon the occurrence of any adjustment to the number of Warrant Shares and Strike Price pursuant to this Clause 4 (Anti-Dilution Protections) with respect to a Warrant Agreement, the Permitted Warrantholder shall surrender such Warrant Agreement and the Company shall issue to the Permitted Warrantholder a replacement Warrant

 

- 21 -


  Agreement, on substantially the same terms as the Warrant Agreements in effect immediately prior to the adjustment event, except as to the number of Warrant Shares and Strike Price, which shall be revised in accordance with the adjustment provisions of this Clause 4 (Anti-Dilution Protections).

 

5.

EVENTS

 

5.1

Notification of Events. The Company shall inform the Permitted Warrantholder promptly if an Event has occurred or is likely to occur (having regard to the relevant facts or circumstances at the time) by serving an Event Notification on the Permitted Warrantholder. Additionally, the Company undertakes to make its best efforts to notify if an Event is likely to occur with such advance as may be reasonable for the Permitted Warrantholder to exercise the Warrants before the relevant Event Date. For this purpose, without limitation, the Company must (i) include the Permitted Warrantholder in all notices to be sent to the Shareholders in relation to the occurrence (or the likely occurrence) of an Event and (ii) shall deliver to the Permitted Warrantholder all notices that it receives from a Shareholder in relation to the occurrence (or the likely occurrence) of an Event.

 

5.2

Ongoing Information about Events. Following service (or deemed service) of an Event Notification, the Company shall keep the Permitted Warrantholder informed in a timely manner of any and all material developments in relation to that Event, or anticipated Event and provide the Permitted Warrantholder in a timely manner with any information of which it becomes aware that might reasonably be required by the Permitted Warrantholder in order for the Permitted Warrantholder to calculate the Fair Market Value of the Warrant Shares by reference to such Event.

 

5.3

Notice if Event unlikely to occur. If, following service (or deemed service) of an Event Notification, it becomes apparent to the Company that the Event in question will not take effect, then the Company shall as soon as practicable give written notice of that fact to the Permitted Warrantholder.

 

6.

WARRANT SETTLEMENT

 

6.1

Warrant Sale and Right of First Refusal.

 

  (a)

No Warrants may be transferred without the prior written consent of the Company until the Maturity Date of the Tranche applicable to such Warrants or the earlier repayment in full of the Loan applicable to such Tranche. Following the applicable Maturity Date or the earlier repayment in full of the applicable Loan, the Permitted Warrantholder may conduct a Warrant Sale in relation to all or some of the applicable Warrants, provided that the Permitted Warrantholder shall deliver a Right of First Refusal Notice to the Company, following which the Company shall have a Right of First Refusal in relation to such Warrants, and may acquire them pursuant to this Clause 6.1 (Warrant Sale and Right of First Refusal) against payment to the Permitted Warrantholder of the purchase price offered for such Warrants by one or several third parties or Shareholders (the “Warrant Sale Price”); provided, that the Company may nominate another person to acquire such Warrants pursuant to the terms of this Clause 6.1 (Warrant Sale and Right of First Refusal) if such nominee is acceptable to the Permitted Warrantholder from a KYC/AML, Sanctions, Non-Compliant Jurisdiction and Restricted Jurisdiction perspective.

 

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  (b)

If the Permitted Warrantholder has exercised the Put Option in relation to any Warrant and the Put Option Price is not, for whatever reason, paid to the Permitted Warrantholder in accordance with, and within the time frame set out in, Clause 6.2 (Put Option), neither the Company (nor its nominee) will be entitled to a Right of First Refusal and a Warrant Sale can be made by the Permitted Warrantholder without compliance with any of the conditions set out in this Clause 6.1 (Warrant Sale and Right of First Refusal). For the avoidance of doubt, a Warrant Sale as described in this Clause 6.1(b) (Warrant Sale and Right of First Refusal) shall be without prejudice to any remedies the Permitted Warrantholder may otherwise have in respect of the relevant the Company’s breach of its obligation to pay the Warrant Sale Price or the Put Option Price under Clause 6.2 (Put Option).

 

  (c)

Within twenty (20) Business Days of the Right of First Refusal Notice being served on the Company, the Company may exercise their Right of First Refusal by written notice to the Permitted Warrantholder and payment of the Warrant Sale Price and all taxes, fees, costs, and expenses incurred by the Permitted Warrantholder in connection with such sale, if not included in the Warrant Sale Price, in cash, by electronic transfer of funds for same day value, to such bank account as the Permitted Warrantholder specifies in the Right of First Refusal Notice.

 

  (d)

Upon receipt of all amounts to be paid to the Permitted Warrantholder in accordance with Clause 6.1(c) (Warrant Sale and Right of First Refusal), the Permitted Warrantholder shall transfer the relevant Warrants to the Company (or its nominee made in accordance with Clause 6.1(a) (Warrant Sale and Right of First Refusal)). In relation to the Warrants so transferred, no representations or warranties whatsoever shall be made by the Permitted Warrantholder other than in relation to the Permitted Warrantholder’s ownership of such Warrants, its authority to sell, and the absence of Encumbrances over such Warrants (other than those imposed by the Permitted Warrantholder or restrictions on transfer under generally applicable securities laws).

 

  (e)

If the Company does not exercise the Right of First Refusal or the Company (or its nominee made in accordance with Clause 6.1(a) (Warrant Sale and Right of First Refusal)) does not make the payment in accordance with, and within the time-frame set out in, Clause 6.1(c) (Warrant Sale and Right of First Refusal), the Permitted Warrantholder may proceed with the Warrant Sale.

 

  (f)

The Right of First Refusal set out in this Clause 6.1 (Warrant Sale and Right of First Refusal) shall not apply to a Warrant Sale if the intended transferee is (a “Permitted Warrantholder Transferee”):

 

  (i)

an Affiliate of the Permitted Warrantholder; provided, however, that such Affiliate agrees in writing to be bound by all of the terms, conditions and provisions contained in this Agreement and the transferor and such Affiliate shall be collectively treated as the “Permitted Warrantholder” for all purposes hereunder; or

 

- 23 -


  (ii)

any person that the receives and assumes the rights, benefits and obligations of the Original Warrantholder under the Finance Contract in accordance with its terms; provided, however, that (A) such person agrees in writing to be bound by all of the terms, conditions and provisions contained in this Agreement as the “Permitted Warrantholder” and (B) shall receive and assume the rights, benefits and obligations of the Permitted Warrantholder under this Agreement and shall be treated as the “Permitted Warrantholder” for all purposes hereunder.

 

6.2

Put Option

 

  (a)

The Company irrevocably grants the Put Option to the Permitted Warrantholder on the terms set forth in this Agreement. The Put Option may be exercised from time-to-time in whole or in part by the Permitted Warrantholder in its sole discretion on or following the earlier of the following dates (as applicable): (i) with respect to the Tranche A Warrants, the Maturity Date of Tranche A, (ii) with respect to the Tranche B Warrants, the Maturity Date of Tranche B, (iii) with respect to the Tranche C Warrants, the Maturity Date of Tranche C or (iv) with respect to any of the Warrants, an Event Date (which exercise can be made on or prior to such Event on the Event Date, but conditional on the occurrence of such Event). In the event that a Material Press Release has been made public by the Company, the Put Option may not be exercised by the Permitted Warrantholder until at least 5 (five) Business Days following the date of such Material Press Release.

 

  (b)

The Put Option shall be exercisable only up to Warrants that would result in the Put Option Price (in aggregate with the final Put Option Price paid in connection with any prior exercise of the Put Option) being no higher than the amount then disbursed pursuant to the Finance Contract.

 

  (c)

The Permitted Warrantholder may exercise the Put Option by serving upon the Company a draft Warrantholder Put Option Notice, which shall be irrevocable except with the consent of the Company. The Permitted Warrantholder shall specify the Fair Market Value it has assumed and the aggregate Put Option Price in respect of the relevant Warrants subject to the Put Option in the draft Warrantholder Put Option Notice.

 

  (d)

The Company shall have the Objection Period to agree or dispute the Permitted Warrantholder’s calculation of Fair Market Value or the aggregate Put Option Price. If, by the end of the Objection Period:

 

  (i)

the Company has not delivered a notice in writing to the Permitted Warrantholder disputing the Permitted Warrantholder’s calculation of Fair Market Value or the aggregate Put Option Price in respect of the applicable Warrants, the Company shall be deemed to have agreed to such calculations in respect of the applicable Warrants, and the draft Warrantholder Put Option Notice shall automatically become final and binding on the Parties; or

 

- 24 -


  (ii)

to the extent that the Company has delivered a notice in writing to the Permitted Warrantholder disputing the Permitted Warrantholder’s calculation of Fair Market Value or the aggregate Put Option Price, the Company or the Permitted Warrantholder may refer the matter to the Expert for determination in accordance with Schedule 3 (Expert Determination).

 

  (e)

Within five (5) Business Days of the Expert’s decision, the Permitted Warrantholder must deliver to the Company a revised Warrantholder Put Option Notice (together with the Supporting Calculations) incorporating such adjustments, if any, as have been determined by the Expert, provided that the Permitted Warrantholder shall have the option to withdraw the Warrantholder Put Option Notice and cancel the proposed exercise of the Put Option if the Fair Market Value or the aggregate Put Option Price is less than 90% of the Fair Market Value or the aggregate estimated Put Option Price included in the Warrantholder Put Option Notice, provided, further, that if the Permitted Warrantholder cancels the proposed exercise of the Put Option, the Permitted Warrantholder shall be responsible for the fees and costs of the Expert. The revised Warrantholder Put Option Notice will supersede the initial draft Warrantholder Put Option Notice and will be final and binding on the Parties from the date of its delivery to the Company provided that it reflects the changes that have been determined by the Expert.

 

  (f)

Within twenty (20) Business Days of the Warrantholder Put Option Notice becoming final and binding in accordance with this Clause 6.2 (Put Option), the Company must pay the aggregate Put Option Price in respect of the applicable Warrants in cash by electronic transfer of funds for same day value to such bank account as the Permitted Warrantholder has specified in the Warrantholder Put Option Notice, whereupon the Warrants will be cancelled and of no further force and effect.

 

  (g)

If the Company fails to pay the aggregate Put Option Price pursuant to this Clause 6.2 (Put Option), then paragraph 4.3 of the Finance Contract relating to the interest on overdue sums shall apply to any overdue Put Option Price.

 

  (h)

In the event that the Permitted Warrantholder seeks to exercise the Put Option and (i) the Company is not cash flow positive as of the end of the Company’s most recent fiscal quarter and (ii) the payment of the aggregate Put Option Price would be reasonably likely to result in the Company not having at least twelve (12) months of cash and cash equivalents on its balance sheet:

 

  (i)

Except with respect to any Warrants subject to a Termination Date within one (1) year of the date of the Warrantholder Put Option Notice, the Company may reject the Put Option if it delivers a written certificate of the Company duly executed by the chief financial officer of the Company representing to the applicable facts set forth above in this Clause 6.2(h) (Put Option), provided, however, that the Company and the Permitted Warrantholder will discuss in good faith the portion of the Warrants that could be subject to the Put Option that would not be restricted by this Clause 6.2(h) (Put Option).

 

- 25 -


  (ii)

With respect to any Warrants subject to a Termination Date within one (1) year of the date of the Warrantholder Put Option Notice, the Company may exercise its right to extend the Termination Date applicable to such Warrants by one (1) year (and the parties will promptly execute amendments to the Warrant Agreements reflecting such extension); provided, that such right may only be exercised one time with respect to any Warrant.

 

7.

PERMITTED WARRANTHOLDER RIGHTS

 

7.1

Third Party Offers

 

  (a)

If an offer, whether direct or indirect, to purchase Shares (or Instruments) (whether involving a formal offer by way of an offer document, an invitation to join a transaction to be evidenced by a sale and purchase agreement or otherwise) is made, to (i) the Shareholders holding more than 50% (fifty percent) of the Shares (or of the Instruments), or (ii) the Shareholders holding 50% (fifty percent) or more of the voting power of the Company, in each case which does not otherwise constitute a Company Share Sale, including upon a Qualifying Tender Offer, the Company shall comply in all respects with the Warrant Agreements.

 

  (b)

If the Permitted Warrantholder decides to exercise the Warrants in order to sell such Warrant Shares in such transaction in accordance with this Agreement, the exercise will be effective immediately prior to the consummation of the transaction, and in no event earlier than 24 (twenty-four) hours prior to the effective time of the closing of such transaction, for subsequent sale to a known purchaser. The Company agrees to cooperate with the Permitted Warrantholder and use its commercially reasonable efforts to ensure that the Warrants exercise occurs within these parameters and does not violate any statutory limitations or regulations to which the Permitted Warrantholder may be subject regarding shareholding or warrant exercise.

 

7.2

Treatment of Warrants upon a Sale of the Company or Change of Control Event. Without prejudice to any other rights the Permitted Warrantholder may have under this Agreement, if (i) a Warrant Sale in accordance with Clause 6.1 (Warrant Sale and Right of First Refusal), (ii) the Put Option pursuant to Clause 6.2 (Put Option), or (iii) a Warrant exercise, including in accordance with Clause 7.1(b) (Third Party Offers), has not been exercised in connection with any Sale or Change of Control Event, the Permitted Warrantholder shall have the rights contemplated by Section 3(c) (Fundamental Transaction) of the Warrant Agreements.

 

8.

ISSUANCE OF WARRANT SHARES

 

8.1

Issuance. The Warrant Shares shall be issued in accordance with the terms of this Agreement and pursuant to the terms of the Tranche A Warrant Agreement, Tranche B Warrant Agreement, and Tranche C Warrant Agreement and upon the payment in full of the then-current Strike Price for the Warrant Shares then being exercised to the Company.

 

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9.

REPRESENTATIONS AND WARRANTIES

 

9.1

REPRESENTATIONS AND WARRANTIES. The Company represents and warrants to the Permitted Warrantholder: (i) on the date of this Agreement, (ii) at the time of any applicable Completion, (iii) at the time of issuance of any Warrants, and (iv) at the time of any exercise (or deemed exercise) of any of the Warrants, the Put Option or the Call Option, that the following statements are accurate and correct, and covenant that the following statements will be accurate and correct at such times.

 

  (a)

The Company:

 

  (i)

has full legal capacity and authority to execute, undertake and comply with its respective obligations under this Agreement, and to carry out all actions required from it in connection with the creation, issuance, and delivery of the Warrants and the satisfaction of all rights of the Permitted Warrantholder pursuant to this Agreement;

(ii) at such time as any Warrant is exercised, will have full legal capacity and authority to carry out all actions required from it in connection with the issuance and delivery of the corresponding Warrant Shares in accordance with Applicable Law, the Charter and any other applicable Organizational Documents, corporate documents, or shareholder resolutions;

 

  (iii)

is duly incorporated and validly existing under the law of its respective jurisdiction to carry out its own business, trade and ordinary activity;

 

  (iv)

has obtained all necessary consents and approvals in connection with the execution, delivery, and performance of this Agreement and in order to lawfully comply with its obligations thereunder and all such consents and approvals are in full force and effect and are admissible in evidence;

 

  (v)

does and will not breach any of its Organizational Documents or any applicable law, statute, rule or regulation, or any judgement, decree or permit binding on it or on its assets by entering into this Agreement;

 

  (vi)

does not breach any agreement or other instrument binding upon it by entering into this Agreement;

 

  (vii)

is not insolvent, over-indebted or subject to a court-ordered restructuring procedure, nor is such insolvency, over-indebtedness or procedure threatened against it; and

 

  (viii)

has reviewed a complete copy of the Finance Contract and has full and complete knowledge of the terms and conditions thereof.

 

  (b)

the Company:

 

  (i)

will have full corporate power and corporate capacity and has obtained all corporate approvals to pay the Put Option Price or any part thereof as and when due;

 

- 27 -


  (ii)

will have full corporate power and corporate capacity and has obtained all corporate approvals to pay the Call Option Price or any part thereof as and when due;

 

  (iii)

has its corporate seat in the United States of America; and

 

  (iv)

as of the date of this Agreement, has granted no Instruments other than those described in Fully Diluted Share Capital of the Company as per Schedule 4 (Capitalization Table).

 

  (c)

the Board of Directors of the Company will, at such time as the Put Option or Call Option is exercised, have full corporate power and capacity under Applicable Law, the Charter, and the other Organizational Documents of the Company, and any relevant decisions by the corporate bodies of the Company, to approve payment of the relevant Put Option Price or Call Option Price in accordance with this Agreement without need for any further approval from any corporate body of the Company or from any third-party.

 

  (d)

the capitalization table set out in Schedule 4 (Capitalization Table) is true, correct and complete and reflects the Fully Diluted Share Capital of the Company as of the date of this Agreement.

 

10.

UNDERTAKINGS

 

10.1

Positive undertakings by the Company. The Company undertakes to the Permitted Warrantholder, in connection with issuing the Warrants and issuing any Warrant Shares to the Permitted Warrantholder following the exercise of the Warrants, to:

 

  (a)

take all acts at its own initiative or upon request from the Permitted Warrantholder in order to implement or facilitate any of the transactions contemplated by, and in compliance with, this Agreement and the Warrant Agreements;

 

  (b)

timely file all reports required to be filed with the SEC pursuant to the Exchange Act; and

 

  (c)

take all such other reasonable action, taking into account Applicable Law in the jurisdiction of the Company, to be necessary or desirable for any of the purposes named in this Clause 10.1 (Positive undertakings by the Company).

 

10.2

Negative undertakings by the Company. For so long as any Warrants remain exercisable or outstanding, the Company shall not, except with the written consent of the Permitted Warrantholder:

 

  (a)

take any action that may result in any Warrants not being exercisable or the Warrant Shares not being issuable in the terms set out in this Agreement and the Warrant Agreements, including revoking any authority granted to any corporate body of the Company to issue the Warrants or the Warrant Shares or to take any prior or subsequent step required under Applicable Law to give effect to either issue;

 

- 28 -


  (b)

alter or amend the rights attaching to the Instruments or the provisions of the Charter or any other Organizational Documents of the Company in such a way which has, or is likely to have, whether at the relevant time or after such time, an adverse effect on the rights, preferences or privileges of the Warrant Shares; or

 

  (c)

convert the Company into an entity of another form under any jurisdiction and in no event shall any such conversion be permitted if the resulting entity will be incorporated or located in a country which is in a jurisdiction that is blacklisted by any Lead Organization in connection with activities such as money laundering, financing of terrorism, tax fraud and tax evasion or harmful tax practices as such blacklist may be amended from time to time.

 

11.

LIQUIDATION OF THE COMPANY

 

11.1

Procedure on Liquidation. If, at any time any Warrants remain exercisable or outstanding, an order is made, or an effective resolution is passed for the liquidation, winding-up, or dissolution of the Company or for any other dissolution of the Company by operation of law:

 

  (a)

the Company shall immediately send to the Permitted Warrantholder a written notice stating that such an order has been made or resolution has been passed or other dissolution is to be effected;

 

  (b)

to the extent permitted by Applicable Law, the Permitted Warrantholder will be entitled to receive out of the Company’s assets which would otherwise be available in the liquidation to the holders of Shares, the amount it would have received under the Charter had it been the holder of the Warrant Shares to which it would have become entitled by virtue of an exercise of the Warrants minus the aggregate Strike Price payable to the Company to exercise such Warrants as of such date; and

 

  (c)

Notwithstanding the foregoing, the Put Option shall automatically be exercised, without notice of further action by any party, upon a Bankruptcy or Insolvency Event.

 

11.2

Subject to compliance with Clause 3 (Issuance of the Warrants) and 11.1 (Procedure on Liquidation), this Agreement will terminate on liquidation of the Company.

 

12.

FINANCE CONTRACT

The following provisions of the Finance Contract are deemed incorporated in this Agreement by reference (except to the extent expressly modified herein) with the same force and effect as though fully set forth herein, regardless of whether the Finance Contract is in force, regardless of whether there is any amount outstanding under the Finance Contract, and regardless of whether the Credit is available thereunder. For the avoidance of doubt, such provisions are solely for the benefit of the Parties to this Agreement.

 

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  (a)

Paragraph (a) of Article 7.1 (Borrower undertakings and representations) of the Finance Contract, save that the references to the Borrower shall be deemed to be references to the Company.

 

  (b)

Paragraph (b) of Article 7.1 (Borrower undertakings and representations) of the Finance Contract, save that:

 

  (i)

the Repeating Representations as defined in the Finance Contract only include the representations set out in Paragraph 1 (Authorizations and Binding Obligations), Paragraph 4 (No proceedings), Paragraph 7 (Anti-Corruption) and Paragraph 8 (Accounting and Tax) of Schedule G (Representations and Warranties) of the Finance Contract; and

 

  (ii)

such Repeating Representations are deemed to be made by the Company on 1 January and 1 July of each year.

 

  (c)

Article 7.2 (Borrower undertakings and representations) of the Finance Contract, save that:

 

  (i)

the undertakings of the Finance Contract which the Company shall undertake include all undertakings in Schedule I (Information and Visits) and the following undertakings in Schedule H (General Undertakings):

 

  (1)

Paragraph 4 (Compliance with laws),

 

  (2)

Paragraph 5 (Environment and Social Matters),

 

  (3)

Paragraph 6 (Integrity),

 

  (4)

Paragraph 10 (Change in business),

 

  (5)

Paragraph 11 (Merger),

 

  (6)

Paragraph 12 (Books and records),

 

  (7)

Paragraph 22 (Maintenance of Status), and

 

  (8)

Paragraph 26 (Sanctions).

 

13.

ASSIGNMENT

 

  (a)

No Party may assign, transfer, charge, or deal in any other manner with any of its rights or obligations under this Agreement, except (i) as otherwise consented to by the Parties in writing or (ii) in the case of the Warrant Holder, to a Permitted Warrantholder Transferee. Subject to the foregoing, and except as otherwise provided herein, this Agreement, and the rights and obligations of the parties hereunder, will be binding upon and inure to the benefit of the respective successors and permitted assignees of the parties.

 

  (b)

Subject to the express provisions of this Agreement, the Warrant Agreements are assignable or transferable in accordance with the terms thereof.

 

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14.

BUSINESS DAYS

Any payment under this Agreement which is due to be made on a day that is not a Business Day shall be made on the next Business Day in the same calendar month (if there is one) or the preceding Business Day (if there is not).

 

15.

CERTIFICATES AND DETERMINATIONS

Any certification or determination by the Permitted Warrantholder of an amount under this Agreement is, in the absence of manifest error, conclusive evidence of the matters to which it relates, save in respect of Clause 6.2 (Put Option) where the Expert’s determination shall be binding in the absence of manifest error.

 

16.

AMENDMENT

Any amendment to this Agreement shall be made in writing and shall be signed by the Parties. For the avoidance of doubt, any accession to this Agreement pursuant to Clause 13 (Assignment) shall not be deemed to be an amendment to this Agreement.

 

17.

WAIVER

Failure to exercise, or a delay in exercising, a right or remedy provided by this Agreement or by law does not constitute a waiver of the right or remedy or a waiver of other rights or remedies. No single or partial exercise of a right or remedy provided by this Agreement or by law prevents the further exercise of the right or remedy or the exercise of another right or remedy. A waiver of a breach of this Agreement does not constitute a waiver of a subsequent or prior breach of this Agreement.

 

18.

RIGHTS AND REMEDIES ARE CUMULATIVE

The rights and remedies provided by this Agreement are cumulative and do not exclude any rights and remedies provided by law.

 

19.

INVALIDITY

If, at any time, any term of this Agreement is or becomes illegal, invalid or unenforceable in any respect, or this Agreement is or becomes ineffective in any respect, under the laws of any jurisdiction, such illegality, invalidity, unenforceability, or ineffectiveness shall not affect:

 

  (a)

the legality, validity, or enforceability in that jurisdiction of any other term of this Agreement or the effectiveness in any other respect of this Agreement in that jurisdiction; or

 

  (b)

the legality, validity or enforceability in other jurisdictions of that or any other term of this Agreement or the effectiveness of this Agreement under the laws of such other jurisdictions.

 

20.

NO PARTNERSHIP

Nothing in this Agreement constitutes a partnership between the Parties or constitutes any Party as agent of another Party for any purpose whatever and, no Party has authority or power to bind the other or to contract in the name of or create liability against another Party in any way or for any purpose.

 

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21.

NOTICES

 

21.1

Contact details. Notices and other communications given under or in connection with this Agreement addressed to a Party shall be made to the address or e-mail address (and the department for whose attention the communication is to be made) as set out below, or to such other address or e-mail address as a Party previously notifies to the other Parties in writing:

 

  (a)

For the Original Warrantholder:

 

Attention:   OPS/EGPF/2-EGILS/[LSB]/[SI]
Address:   The European Investment Bank
  100 boulevard Konrad Adenauer
  L-2950 Luxembourg

With a copy to (which shall not constitute notice):

 

Attention:   Matthew K. Warner
  Partner
Address:   Clifford Chance US LLP
  Two Manhattan West
  375 9th Avenue
  New York, NY 10019
  USA
E-mail address:   matthew.warner@cliffordchance.com

 

  (b)

For the Company:

 

Attention:   IO Biotech, Inc.
Address:   IO Biotech, Inc.
  Ole Maaløes Vej 3
  DKK-220 Copenhagen N
  Denmark

With copies to (which shall not constitute notice):

 

Attention:   Devin Smith
  General Counsel
Address:   IO Biotech, Inc.
  430 E 29th St
  Suite 940
  New York, NY 10016
  USA

and:

 

- 32 -


Attention:   Frank Rahmani
Address:   Sidley Austin LLP
  1001 Page Mill Rd., Building 1
  Palo Alto, California 94304
  USA
E-mail address:   frahmani@sidley.com

 

  (c)

For any Permitted Warrantholder other than the Original Warrantholder, such address, attention and e-mail address as that Permitted Warrantholder may notify the other Parties pursuant to the notice provisions of this Clause 21 (Notices).

 

21.2

Changes to notice address. Each Party shall promptly notify the other Parties in writing of any change in their respective communication details.

 

21.3

Language for notices. Any notice or other communication given under this Agreement must be in writing and in the English language.

 

21.4

Notices setting deadlines. Notices and other communications, for which fixed periods are laid down in this Agreement or which themselves fix periods binding on the addressee, may be made by hand delivery or registered letter with acknowledgement of receipt. Such notices and communications shall be deemed to have been received by the relevant Party on the date of delivery.

 

21.5

Other notices. Other notices and communications may be made may be made by hand delivery, registered letter, or e-mail, which shall be effective upon confirmation of receipt.

 

21.6

Notices by e-mail. Without affecting the validity of any notice delivered by e-mail according to the paragraphs above, a copy of each notice delivered by e-mail shall also be sent by letter to the relevant Party on the next following Business Day at the latest.

 

21.7

Evidence of signing authority. Notices issued by the Company pursuant to any provision of this Agreement shall, where required by the Permitted Warrantholder, be delivered to the Permitted Warrantholder together with satisfactory evidence of the authority of the person or persons authorized to sign such notice on behalf of the Company and the authenticated specimen signature of such person or persons.

 

22.

COSTS

 

22.1

The Company shall bear the costs and expenses of the Permitted Warrantholder in relation to the preparation, negotiation, execution, implementation, enforcement and termination of this Agreement or any ancillary documents, as well as any subsequent amendments, supplements, or waivers of or to this Agreement or any ancillary document, including the costs of any legal, accountancy, and other advisors and any exchange charges incurred, provided that the Company shall not be responsible for any costs or expenses of the Permitted Warrantholder in connection with a transfer or sale of the Warrants or Warrant Shares by the Permitted Warrantholder. All legal costs incurred by the Permitted Warrantholder, including local counsel, shall be borne by the Company and payable as a condition precedent to the disbursement of Tranche A, Tranche B, and Tranche C, as the case may be, under the Finance Contract.

 

- 33 -


23.

TAXES, DUTIES, AND FEES; INTEREST ON OVERDUE SUMS; PAYMENTS

 

23.1

Company to pay all taxes. The Company shall pay all taxes, duties, fees, and other impositions of whatsoever nature , including stamp duty and registration fees, arising out of the creation, preparation, execution, implementation, perfection, registration, enforcement, amendment (including supplements and waivers) or termination arising out of this Agreement, any Warrants Agreements, or any ancillary document, including in connection with the exercise of the Warrants or of the Put Option or Call Option as set out under this Agreement, provided that the Company shall not be responsible for (i) any transfer tax payable in connection with the Permitted Warrantholder transferring or selling the Warrants or Warrant Shares, (ii) any capital gains and income taxes and any similar taxes and duties attributable to the Permitted Warrantholder, or (iii) any incremental tax due to the identity or tax characteristics of the Permitted Warrantholder as compared to the Original Warrantholder.

 

23.2

Company to gross up. The Company (or any nominee thereof paying any amount due under this Agreement) shall pay all amounts due to the Permitted Warrantholder under this Agreement gross without any withholding or deduction of any national or local impositions whatsoever, provided that if any such withholding or deduction is required by law or by an agreement with a governmental authority or otherwise, the Company (or such nominee) will gross up the payment to the Permitted Warrantholder so that after withholding or deduction, the net amount received by the Permitted Warrantholder is equivalent to the sum due; provided further that, the Parties shall cooperate and use their commercially reasonable efforts to deliver any documentation that may be required as will permit such amounts to be made without withholding or at a reduced rate of withholding.

 

23.3

Interest. If the Company fails to pay any amount payable to the Permitted Warrantholder by it under this Agreement on its due date, interest shall accrue on any such overdue amount from the due date to the date of actual payment at an annual rate equal to EURIBOR plus 2% (two percent) (200 (two hundred) basis points) and shall be payable in accordance with the demand of the Permitted Warrantholder. The Borrower hereby agrees in advance to have the unpaid interest due for a period of more than 1 (one) year compounded and such unpaid interest will in turn produce interest at the interest rate set out in this Clause 23.3 (Interest).

 

23.4

Currency. If the overdue amount is in a currency other than the currency of the Loan, the relevant interbank rate, or as determined by the Permitted Warrantholder, the relevant risk-free rate that is generally retained by the Permitted Warrantholder for transactions in that currency plus 2% (two percent) (200 (two hundred) basis points) shall apply, calculated in accordance with the market practice for such rate.

 

23.5

Fractional time. Any amount due under this Clause 23.3 (Interest) and calculated in respect of a fraction of a year shall be determined based on a year of three hundred and sixty (360) days and the number of days elapsed.

 

- 34 -


23.6

Timing and method of payment.

 

  (a)

Any sum payable by the Company to the Permitted Warrantholder under this Agreement or any Warrant Agreement shall be paid promptly to such account as notified by the Permitted Warrantholder to the Company in writing, provided that such account complies with Applicable Law.

 

  (b)

Any disbursements by and payments to the Permitted Warrantholder under this Agreement or any Warrant Agreement shall be made using account(s) acceptable to the Permitted Warrantholder. Any account in the name of the Company held with a duly authorized financial institution in the jurisdiction where the Company is incorporated or where the Investment (as defined in the Finance Contract) is undertaken is deemed acceptable to the Permitted Warrantholder.

 

24.

Eur

Payments to be made by the Company to the Permitted Warrantholder hereunder and under any Warrant Agreement shall be made in EUR, unless otherwise agreed in writing with the Permitted Warrantholder. To the extent any amount to be paid to the Permitted Warrantholder originally are in USD, the amount will be converted from USD to EUR, applying the average foreign exchange (FX) rate over the last ninety (90) days as calculated by Bloomberg.

 

25.

SET-OFF

 

25.1

No set-off by the Company. All payments to be made by the Company to the Permitted Warrantholder under this Agreement shall be calculated and be made without (and free and clear of any deduction for) set-off or counterclaim.

 

25.2

Set-off by Permitted Warrantholder. The Permitted Warrantholder may set off any matured obligation due from the Company (to the extent beneficially owned by the Permitted Warrantholder) against any obligation (whether or not matured) owed by the Permitted Warrantholder to the Company (including the Strike Price owed with respect to any Warrants), regardless of the place of payment, booking branch, or currency of either obligation. If the obligations are in different currencies, the Permitted Warrantholder may convert either obligation at a market rate of exchange in its usual course of business for the purpose of the set-off. If either obligation is unliquidated or unascertained, the Permitted Warrantholder may set off in an amount estimated by it in good faith to be the amount of that obligation. All payments to be made by a Warrantholder (as defined in the Warrant Agreements) other than the Permitted Warrantholder under this Agreement shall be calculated and made without (and free and clear of any deduction for) set-off or counterclaim.

 

26.

COUNTERPARTS

This Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument. Each counterpart is an original, but all counterparts shall together constitute one and the same instrument.

 

- 35 -


27.

FURTHER ASSURANCE

The Company shall, at its cost, execute all documents and do all acts and things as the Permitted Warrantholder might reasonably consider necessary or desirable for the purpose of giving the Permitted Warrantholder the full benefit of all the provisions of this Agreement.

 

28.

THIRD PARTY RIGHTS

A person who is not a Party hereto is not entitled to any rights under this Agreement.

 

29.

MUTUAL DRAFTING

This Agreement is the joint product of the Original Warrantholder and the Company and each provision hereof has been subject to the mutual consultation, negotiation and agreement of such parties and shall not be construed for or against any party hereto.

 

30.

ENTIRE AGREEMENT

This Agreement, the Warrant Agreements, and the other agreements and documents referred to herein constitute the entire agreement between the Parties in relation to the grant of the Warrants and the issuance of Warrant Shares, and supersedes any previous agreement, whether express or implied, on the same matter.

 

31.

GOVERNING LAW; JURISDICTION; WAIVER OF TRIAL BY JURY; REMEDIES

 

31.1

This Agreement and any non-contractual obligations arising out of or in connection with it shall be governed by and construed in accordance with the laws of the State of New York, without regard to any to principles of conflicts or choice of law in the State of New York or in any other state.

 

31.2

Each of the Parties irrevocably and unconditionally submits, for itself and its property, to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan, in any action or proceeding arising out of or relating to this Agreement for recognition or enforcement of any judgment, and each of the Parties hereto irrevocably and unconditionally agrees, to the fullest extent permitted by Applicable Law, that all claims in respect of any such action or proceeding may be heard and determined in such state or federal court sitting in the City of New York in the Borough of Manhattan. Each of the Parties hereto agrees that a final judgment in any such action or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by law.

 

31.3

EACH OF THE PARTIES TO THIS AGREEMENT IRREVOCABLY AND UNCONDITIONALLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY RIGHT IT MAY HAVE TO TRIAL BY JURY IN RESPECT OF ANY LEGAL ACTION OR LITIGATION ARISING OUT OF, OR IN CONNECTION WITH, OR RELATING TO, THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY, IN EACH CASE WHETHER NOW EXISTING OR HEREAFTER ARISING, AND WHETHER IN CONTRACT, TORT, EQUITY, OR OTHERWISE.

 

- 36 -


31.4

The Permitted Warrantholder, in addition to being entitled to exercise all rights granted by Applicable Law, including recovery of damages, will be entitled to specific performance of its rights under this Agreement. The Company agrees that monetary damages would not be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Agreement, and hereby agrees to waive and not to assert the defense in any action for specific performance that a remedy at law would be adequate.

 

32.

NO MNPI OR PROHIBITED DISCLOSURES

 

32.1

Notwithstanding anything set out in this Agreement (including, but not limited to, in Clause 5 (Events)), the Company shall not be required to submit any information to the Permitted Warrantholder to the extent (i) such information constitutes confidential information of a third party and disclosure is prohibited by agreement between the Company and such third party, (ii) such information is not in the Company’s possession and is not reasonably obtainable, or (iii) this would be contrary to applicable mandatory laws.

 

32.2

If considered necessary by the Permitted Warrantholder and to the extent possible pursuant to applicable laws, the Parties shall cooperate or conclude separate arrangements in order to grant the Permitted Warrantholder access to such information or documents that cannot otherwise be provided to the Permitted Warrantholder pursuant to Clause 32.1 (No MNPI or Prohibited Disclosures), specifically resulting from relevant provisions of other confidentiality agreements or relevant laws regulating access to such information or documents.

 

32.3

To the extent any information is disclosed to the Permitted Warrantholder and such information constitutes, in the Company’s reasonable judgment, material non-public information (“MNPI”), the Company shall (i) clearly designate the information as such and the Company shall provide notice to the Permitted Warrantholder in advance of providing to the Permitted Warrantholder any such MNPI, (ii) only provide the Permitted Warrantholder with such information and only to the persons that the Permitted Warrantholder has disclosed to the Company as being authorized to receive such information, (iii) label the information such that it is clear that the information qualifies as MNPI, (iv) clearly designate the information as indicate the sections of the information provided to the Permitted Warrantholder qualifies as “MNPI,” (v) clearly indicate the basis on which the information is being disclosed to the Permitted Warrantholder and confirming that the information has not been unlawfully disclosed and (vi) provide the Permitted Warrantholder with information as to the time at which the Company expects such information will no longer be classified as MNPI.. To the extent that the Company discloses information to the Permitted Warrantholder and does not believe such information constitutes MNPI and the Permitted Warrantholder disagrees with the Company’s determination, the Permitted Warrantholder may submit a request for information reasonably required to understand the rationale behind the Company’s determination and the Company will provide such information within two (2) Business Days following the Permitted Warrantholder’s request for information.

 

- 37 -


32.4

Without prejudice to the other rights of the Permitted Warrantholder set forth in this Agreement, the Permitted Warrantholder may at any time deliver written notice (an “Opt-out Notice”) to the Company requesting that the Permitted Warrantholder not receive materials designated as containing MNPI; provided however that such Opt-out Notice may be subsequently revoked by the Permitted Warrantholder at any time. Following receipt of an Opt-Out Notice from the Permitted Warrantholder (unless subsequently revoked), (i) the Company shall not deliver any MNPI to the Permitted Warrantholder, except as required by applicable law and (ii) for the avoidance of doubt, the Company shall not be required to deliver any MNPI to the Permitted Warrantholder notwithstanding the provisions of this Agreement.

 

32.5

To the extent that the Permitted Warrantholder does receive MNPI in accordance with this Agreement, the Permitted Warrantholder will: (a) take all reasonable steps to hold in trust and confidence such MNPI and not use such MNPI for any purpose other than to evaluate its rights under this Agreement (the “Purpose”), (b) not disclose such MNPI, except to its Affiliates and its and their employees, consultants, contractors, subcontractors and agents who (i) require access to such MNPI for the Purpose, and (ii) have been informed of the limitations on use and disclosure of such MNPI created by this Agreement, (c) maintain the confidentiality of the MNPI with at least the same degree of care as it maintains the confidentiality of its own confidential information, and in any event, at least a reasonable standard of care and (d) process any personal data contained in MNPI solely in accordance with applicable data protection legislation.

 

33.

TERMINATION

This Agreement shall automatically terminate without the action of any Party at such time as no Permitted Warrantholder (i) holds any Warrants or (ii) has a right (conditional or otherwise) to receive any additional Warrants pursuant to the terms of this Agreement. Upon such termination, no Party will have any further rights, obligations or liabilities under this Agreement; provided, that (i) the provisions of this Section 33 (Termination), Section 18 (Rights and Remedies Are Cumulative), Section 19 (Invalidity), Section 20 (No Partnership), Section 21 (Notices), Section 22 (Costs), Section 23 (Taxes, Duties, and Fees; Interest on Overdue Sums; Payments) Section 24 (EUR), Section 25 (Set-Off), Section 26 (Counterparts), Section 27 (Further Assurances), Section 28 (Third Party Rights), Section 29 (Mutual Drafting), Section 30 (Entire Agreement) and Section 31 (Governing Law; Jurisdictions; Waiver of Trial by Jury; Remedies) will survive any termination of this Agreement, (ii) the Permitted Warrantholder’s obligations under Clause 32 (No MNPI or Prohibited Disclosures) with respect to any MNPI received prior to such termination will survive for a period of twelve (12) months following such termination and (iii) no such termination will relieve any Party from any liabilities, losses, damages, obligations, costs or expenses relating to such Party’s willful breach of this Agreement, or Fraud.

THIS AGREEMENT has been entered into on the date stated at the beginning of this Agreement.

[The remainder of this page is intentionally left blank. Signatures to follow.]

 

- 38 -


SIGNATURE PAGE TO THE WARRANT ISSUANCE AGREEMENT

THIS AGREEMENT has been entered into on the date stated at the beginning of this Agreement.

 

ORIGINAL WARRANTHOLDER

 

Executed by

 

The European Investment Bank

 

acting by:

 

/s/ Maria-Teresa MASSAAD

   

/s/ Yu ZHANG

Name:  

Maria-Teresa MASSAAD

    Name:  

Yu ZHANG

Title:  

Head of Division

       Title:  

Head of Division

[Signature Page to Warrant Issuance Agreement]


SIGNATURE PAGE TO THE WARRANT ISSUANCE AGREEMENT

THIS AGREEMENT has been entered into on the date stated at the beginning of this Agreement.

 

COMPANY

Executed by

IO Biotech, Inc.

acting by:

 

/s/ Mai-Britt Zocca

     
Name:   Mai-Britt Zocca      
Title:   Chief Executive Officer      

[Signature Page to Warrant Issuance Agreement]


SCHEDULE 1

FORM OF WARRANT AGREEMENT

[See attached]


SCHEDULE 2

WARRANTHOLDER PUT OPTION NOTICE

(THE “NOTICE”)

 

To:

IO Biotech, Inc.

Ole Maaløes Vej 3

DKK-220 Copenhagen N

Denmark

Attention: Mai-Britt Zocca

FAO:

[ *** ]

Warrant Issuance Agreement, between IO Biotech, Inc. and the European Investment Bank, dated December 19, 2024 (the “Warrant Issuance Agreement”)

We refer to the Warrant Issuance Agreement. Capitalized terms used in this Notice have the meanings ascribed to them in the Warrant Issuance Agreement.

We hereby provide this notice for the exercise of the Put Option with respect to [Tranche [ *** ]1 Warrants to purchase [ *** ] Warrant Shares.

Our good faith calculations of Fair Market Value and the Put Option Price applicable to such exercise of the Put Option are set out in the annex to this Notice, where the basis of calculation, assumptions and working papers are shown.

Pursuant to such calculations, the Put Option Price for such exercise of the Put Option is EUR [ *** ].

Please countersign this Notice to indicate your acceptance of this Notice and remit the Put Option Price to the following account:

 

Bank:    [ *** ]
Branch:    [ *** ]
Sort Code:    [ *** ]
Account Number:    [ *** ]
Account name:    [ *** ]
BIC:    [ *** ]
SWIFT:    [ *** ]
IBAN:    [ *** ]
Reference:    Put Option of IO Biotech, Inc. Warrants

Signed by                

for and on behalf of

European Investment Bank

Full Name                

Address                 

                    

                    

 

1 

NOTE TO FORM: To be adapted if Warrants under multiple tranches are to be subject to the Put Option.


We hereby confirm our agreement to the Warrantholder Put Option Notice becoming final and binding.

Signed by                

for and on behalf of

IO Biotech, Inc.

Full Name                

Address:

IO Biotech, Inc.

Ole Maaløes Vej 3

DKK-220 Copenhagen N

Denmark

Attention: Mai-Britt Zocca

E-mail address mz@iobiotech.com


ANNEX A

SUPPORTING CALCULATIONS

[To be prepared at the time of a Notice]


SCHEDULE 3

EXPERT DETERMINATION

 

1.

IDENTITY AND SELECTION OF EXPERT

The Expert will be an independent and leading investment bank, an independent, leading global firm of accountants, or an independent, leading valuation firm, as jointly appointed by the Company and the Permitted Warrantholder which has not rendered material services to either Party during the period commencing 3 (three) years prior to the date of the Warrant Issuance Agreement through to the date of exercise of the Put Option. Failing agreement as to such appointment after twenty (20) Business Days of the proposed referral to the Expert pursuant to paragraph (d) of Clause 6.2 (Put Option) by the Permitted Warrantholder or the Company, the Permitted Warrantholder shall (in its sole discretion acting reasonably) appoint an Expert satisfying the above criteria ensuring that they are an independent valuation firm of recognized standing engaged in the business of valuing venture capital backed companies at all stages of development (from start-up to maturity).

 

2.

DUTIES OF EXPERT

The Expert will:

 

  (a)

determine (as appropriate) the Fair Market Value for any Warrant Shares on the basis set out in paragraph 3 (Basis of Valuation); and

 

  (b)

within one (1) month of the matter being referred to it, give written notice of its determination to the Parties (the “Expert’s Certificate”), together with a written explanation setting out in reasonable detail the basis and methods used for the purposes of the calculations performed under the previous subparagraph.

 

3.

BASIS OF VALUATION

Fair Market Value shall be determined as follows:

 

  (a)

if Shares of Common Stock are listed on a Trading Market, Fair Market Value shall be equal to the 5-Day VWAP; or

 

  (b)

if Shares of Common Stock are not listed on a Trading Market, the fair market value of a Share of Common Stock as determined in accordance with the following valuation principles:

 

  1.

based on the full equity value of the Company and the terms of its outstanding securities without any discount for lack of liquidity, lack of control, restrictions on marketability, minority interests or lack of other rights of equity holders;

 

  2.

by applying techniques that are appropriate in light of the nature, facts, and circumstances of such Shares;

 

  3.

using reasonable current market data and inputs combined with market participant assumptions; and


  4.

taking into account valuations retained in previous transaction or offers related to Instruments of the Company over the preceding twelve (12) month period;

 

  5.

based on the price that would be received for an asset or paid to transfer a liability in an Orderly Transaction, given market conditions at the measurement date, between market participants that are (i) independent of each other, (ii) knowledgeable of the market, (iii) able to transact and willing to transact, that is, they are motivated but not forced or otherwise compelled to do so. For the purposes hereof, any preferred rights shall be taken into consideration for the purposes of such valuation. For the avoidance of doubt, should part of the price be paid in kind (e.g., by exchange with shares of the acquirer), the Put Option Price shall be settled in cash by the Borrower in accordance with Clause 6.2 (Put Option), based on the cash consideration for a Share of Common Stock;

 

  6.

adding up any common and preferred distributions made to Shareholders or holder of Instruments giving rise to any kind of distribution or profit entitlement since the date of issuance of the respective Warrants which have not been paid to the Permitted Warrantholder;

 

  7.

such valuation to be by guided by the International Private Equity and Venture Capital Valuation Guidelines as such are amended from time to time.

For the purposes of this paragraph 3 (Basis of Valuation), “Orderly Transaction” means a transaction that assumes exposure to the market for a period prior to the measurement date to allow for marketing activities that are usual and customary for transactions involving the respective assets or liabilities of a company or business like the Company at such time.

 

4.

TERMS OF APPOINTMENT OF EXPERT

The Parties shall cooperate with each other and shall take all reasonable action as is necessary to ensure that the terms of appointment of the Expert will enable the Expert to give effect to and act in accordance with the provisions of this Schedule 3.

 

5.

EXPERT REFUSING OR CEASING TO ACT

If the Expert is unable for whatever reason to act, or does not deliver the decision within the time required by paragraph 2(b) (Duties of Expert), the Company and the Permitted Warrantholder shall appoint a replacement expert in accordance with paragraph 1 (Identity and Selection of Expert) of this Schedule 3.

 

6.

LANGUAGE

All matters under this Schedule 3 will be conducted, and the Expert’s decision will be written, in the English language.


7.

PARTIES TO PROVIDE INFORMATION AND MAKE SUBMISSIONS

The Parties are entitled to make submissions to the Expert including oral submissions and shall provide (or procure that others provide) the Expert with such information, assistance, and documents necessary or as the Expert reasonably requires for the purpose of reaching a decision, subject to the Expert agreeing to give such confidentiality undertakings as the Parties may reasonably require.

Any information disclosed to the Expert by the Company, or any person for or on behalf the Company shall also be disclosed simultaneously to the Permitted Warrantholder.

 

8.

EXPERT MAY DETERMINE PROCEDURES

To the extent not provided for by this Schedule 3, the Expert may, in its reasonable discretion, determine such other procedures consistent with best practices to assist with the conduct of the determination as such Expert considers just or appropriate, including (to the extent it considers necessary) instructing professional advisers to assist it in reaching its determination.

 

9.

CONDUCT OF PARTIES

The Parties shall promptly take all such reasonable action which is necessary to give effect to the terms of this Schedule 3.

 

10.

EXPERT NOT ARBITRATOR

The Expert will act as an expert and not as an arbitrator. The Expert will determine any dispute arising in connection with the provisions of this Schedule 3, its jurisdiction to determine the matters and issues referred to it, or its terms of reference. The Expert’s written decision on the matters referred to it will be final and binding in the absence of manifest error or fraud.

 

11.

COSTS OF THE EXPERT

Except as otherwise set forth in paragraph (e) of Clause 6.2 (Put Option), the Expert’s fees and any costs properly incurred by it in arriving at any determination (including any fees and costs of any advisers appointed by the Expert) will be paid to the Expert by the Company.

[The remainder of this page is intentionally left blank.]


SCHEDULE 4

CAPITALIZATION TABLE

[See attached]


EXHIBIT A

CHARTER

[See Attached]

 

[Exh A-1]

Exhibit 10.5

REGISTRATION RIGHTS AGREEMENT

IO BIOTECH (IEU LS) (Serapis No: 2024-0179; FI No: 97869)

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of December 19, 2024, is entered into by and between IO BIOTECH, INC., a Delaware corporation (the “Company”), and the European Investment Bank, having its seat at 98-100 Boulevard Konrad Adenauer, L-2950 Luxembourg (together with its successors and permitted assigns, the “Warrantholder”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Warrant Issuance Agreement, by and among the parties hereto, dated as of the date hereof (as amended, restated, supplemented or otherwise modified from time to time, the “Warrant Issuance Agreement”).

WHEREAS:

A. The Warrantholder has agreed to provide a loan facility to the Borrower, a wholly-owned subsidiary of the Company, pursuant to that certain Finance Contract, dated as of the date hereof (as amended, restated, supplemented or otherwise modified from time to time, the “Finance Contract”).

B. Upon the terms and subject to the conditions of the Warrant Issuance Agreement, the Company has agreed to grant to the Warrantholder the Tranche A Warrants, Tranche B Warrants, and Tranche C Warrants (collectively, the “Warrants”) to purchase shares of the Company’s common stock, par value $0.001 per share (the “Common Stock”) pursuant to the Warrant Issuance Agreement. The shares of Common Stock issuable upon exercise of the Warrants are collectively referred to herein as the “Shares.”

C. To induce the Warrantholder to enter into the Finance Contract and Warrant Issuance Agreement, the Company has agreed to provide certain registration rights under the Securities Act of 1933, as amended, and the rules and regulations thereunder, or any similar successor statute (collectively, the “Securities Act”), and applicable state securities laws.

NOW, THEREFORE, in consideration of the promises and the mutual covenants contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and the Warrantholder hereby agree as follows:

1. DEFINITIONS.

For purposes of this Agreement, the following terms shall have the following meanings:

Business Day” means a day (other than a Saturday or Sunday) on which the Warrantholder and commercial banks are open for general business in Copenhagen, Luxembourg, and New York, New York.

Final Warrant Issuance Date” means the date in which the Tranche A Warrants, Tranche B Warrants and the Tranche C Warrants have been issued pursuant to the Warrant Issuance Agreement or such earlier date on which the Company has no outstanding obligation to issue Warrants under the Warrant Issuance Agreement.


Permitted Warrantholder Transferee” means any “Permitted Warrantholder Transferee” (as defined in the Warrant Issuance Agreement) that is assigned rights of the Warrantholder under the Warrant Issuance Agreement in accordance with the terms thereof.

Person” means any individual or entity including but not limited to any corporation, limited liability company, association, partnership, organization, business, individual, governmental or political subdivision thereof or a governmental agency.

Register,” “Registered,” and “Registration” refer to a registration effected by preparing and filing one or more registration statements of the Company in compliance with the Securities Act and providing for offering securities on a continuous basis, and the declaration or ordering of effectiveness of such registration statement(s) by the United States Securities and Exchange Commission (the “SEC”).

Registrable Securities” means the Shares and any Common Stock issued or issuable with respect to the Shares as a result of any stock split or subdivision, stock dividend, recapitalization, exchange or similar event. Registrable Securities shall cease to be Registrable Securities upon the expiration of the Registration Period (as defined in Section 2(b)).

Registration Expenses” shall mean all registration and filing fee expenses incurred by the Company in effecting any registration pursuant to this Agreement, including (i) all registration, qualification, and filing fees, printing expenses, and any other fees and expenses associated with filings required to be made with the SEC, FINRA or any other regulatory authority, (ii) all fees and expenses in connection with compliance with or clearing the Registrable Securities for sale under any securities or “Blue Sky” laws, (iii) all printing, duplicating, word processing, messenger, telephone, facsimile and delivery expenses, (iv) all fees and disbursements of counsel for the Company and of all independent certified public accountants of the Company (including the expenses of any special audit and cold comfort letters required by or incident to such performance), and (v) all fees and disbursements of counsel for the Warrantholder during the term of this Agreement, in an amount not to exceed $35,000.

Registration Statement” means any registration statement of the Company filed with, or to be filed with, the SEC under the Securities Act, that Registers Registrable Securities, including the related prospectus, amendments and supplements to such registration statement, including pre- and post-effective amendments, and all exhibits and all material incorporated by reference in such registration statement as may be necessary to comply with applicable securities laws. “Registration Statement” shall also include a New Registration Statement, as amended when each became effective, including all documents filed as part thereof or incorporated by reference therein, and including any information contained in a prospectus subsequently filed with the SEC.

Selling Expenses” shall mean all underwriting discounts and selling commissions applicable to the sale of Registrable Securities and all similar fees and commissions relating to the Warrantholder’s disposition of the Registrable Securities.


2. REGISTRATION.

(a) Mandatory Registration. The Company shall, as promptly as reasonably practicable and in any event by the later of (i) 30 days following the date on which the warrants are issued pursuant to the Warrant Issuance Agreement and (ii) May 15, 2025, prepare and file with the SEC an initial Registration Statement (the “Initial Registration Statement”) covering the resale of all Registrable Securities issuable in connection with such warrants. Before filing the Registration Statement, the Company shall furnish to the Warrantholder a copy of the Registration Statement. The Warrantholder and their counsel shall have at least six (6) Business Days prior to the anticipated filing date of a Registration Statement to review and comment upon such Registration Statement and any amendment or supplement to such Registration Statement and any related prospectus (including any documents incorporated by reference therein), prior to its filing with the SEC. The Company shall (a) use its reasonable best efforts to address in each such document prior to being so filed with the SEC such comments as the Warrantholder or its counsel reasonably proposed by the Warrantholder, and (b) not file any Registration Statement or related prospectus or any amendment or supplement thereto containing information regarding the Warrantholder to which Warrantholder reasonably objects, unless such information is required to comply with any applicable law or regulation. The Warrantholder shall furnish all information reasonably requested by the Company and as shall be reasonably required in connection with any registration referred to in this Agreement.

(b) Effectiveness Deadline. The Company shall use its reasonable best efforts to have the Initial Registration Statement and any amendment declared effective by the SEC at the earliest possible date but no later than the earlier of the seventy-fifth (75th) calendar day following the initial filing date of the Initial Registration Statement if the SEC notifies the Company that it will “review” the Initial Registration Statement and (b) the fifth (5th) Business Day after the date the Company is notified (orally or in writing, whichever is earlier) by the SEC that the Initial Registration Statement will not be “reviewed” or will not be subject to further review. The Company shall notify the Warrantholder by e-mail as promptly as practicable, and in any event, within twenty-four (24) hours, after the Registration Statement is declared effective or is supplemented and shall provide the Warrantholder with copies of any related prospectus to be used in connection with the sale or other disposition of the securities covered thereby. The Company shall use reasonable best efforts to keep the Initial Registration Statement effective pursuant to Rule 415 promulgated under the Securities Act and available for the resale of the Registrable Securities covered thereby at all times until the earliest to occur of the following events after the Final Warrant Issuance Date: (i) the date on which the Warrantholder shall have resold all the Registrable Securities covered hereby; and (ii) the date on which the Registrable Securities may be resold or transferred by the Warrantholder without registration and without regard to any volume or manner-of-sale limitations by reason of Rule 144, without the requirement for the Company to be in compliance with the current public information requirement under Rule 144 under the Securities Act or any other rule of similar effect, and new certificates for such securities not bearing a legend restricting further transfer have been issued to the Warrantholder (the “Registration Period”). The Initial Registration Statement (including any amendments or supplements thereto and prospectuses contained therein) shall not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein, or necessary to make the statements therein, in light of the circumstances in which they were made, not misleading.

(c) Sufficient Number of Shares Registered. In the event the number of shares available under the Initial Registration Statement at any time is insufficient to cover the Registrable Securities under the Tranche A Warrants, and in connection with the issuance of the Tranche B Warrants and Tranche C Warrants, the Company shall, to the extent necessary and permissible,


amend the Initial Registration Statement or file a new registration statement (together with any prospectuses or prospectus supplements thereunder, a “New Registration Statement”), so as to cover all of such Registrable Securities as soon as reasonably practicable, but in any event not later than thirty (30) Business Days after the necessity therefor arises. The Company shall use its reasonable best efforts to have such amendment and/or New Registration Statement become effective as soon as reasonably practicable following the filing thereof.

(d) Rule 415; Cutback. If at any time the SEC takes the position that the offering of some or all of the Registrable Securities in any Registration Statement is not eligible to be made on a delayed or continuous basis under the provisions of Rule 415 under the Securities Act (provided, however, the Company shall be obligated to use reasonable best efforts to advocate with the SEC for the registration of all of the Registrable Securities) or requires the Warrantholder to be named as an “underwriter,” the Company shall (i) promptly notify each holder of Registrable Securities thereof and (ii) make commercially reasonable efforts to persuade the SEC that the offering contemplated by such Registration Statement is a valid secondary offering and not an offering “by or on behalf of the issuer” as defined in Rule 415 and that the Warrantholder is not an “underwriter.” The Warrantholder shall have the right to have its legal counsel, at the Company’s expense, to review and oversee any registration or matters pursuant to this Section 2(d), including participation in any meetings or discussions with the SEC regarding the SEC’s position and to comment on any written submission made to the SEC with respect thereto. No such written submission with respect to this matter shall be made to the SEC to which the Warrantholder’s counsel reasonably objects. In the event that, despite the Company’s reasonable best efforts and compliance with the terms of this Section 2(d), the SEC refuses to alter its position, the Company shall (i) remove from such Registration Statement such portion of the Registrable Securities (the “Cut Back Shares”) and/or (ii) agree to such restrictions and limitations on the registration and resale of the Registrable Securities as the SEC may require to assure the Company’s compliance with the requirements of Rule 415 (collectively, the “SEC Restrictions”); provided, however, that the Company shall not name the Warrantholder as an “underwriter” in such Registration Statement without the prior written consent of the Warrantholder (provided that, in the event the Warrantholder withholds such consent, the Company shall have no obligation hereunder to include any Registrable Securities of the Warrantholder in any Registration Statement covering the resale thereof until such time as the SEC no longer requires the Warrantholder to be named as an “underwriter” in such Registration Statement or the Warrantholder otherwise consents in writing to being so named). Any cutback imposed on the Warrantholder pursuant to this Section 2(d) shall be allocated among the holders of any previously or subsequently registered shares of Common Stock whose shares are subject to the Rule 415 position taken by the SEC on a pro rata basis unless the SEC Restrictions otherwise require.

3. RELATED COMPANY OBLIGATIONS.

With respect to the Registration Statement and whenever any Registrable Securities are to be Registered pursuant to Section 2, including on the Initial Registration Statement or on any New Registration Statement, the Company shall use its reasonable best efforts to effect the registration of the Registrable Securities in accordance with the intended method of disposition thereof and, pursuant thereto, the Company shall have the following obligations:


(a) Notifications. The Company will promptly notify the Warrantholder of the time when any subsequent amendment to the Initial Registration Statement or any New Registration Statement, other than documents incorporated by reference, has been filed with the SEC and/or has become effective or where a receipt has been issued therefor or any subsequent supplement to a prospectus has been filed and of any request by the SEC for any amendment or supplement to the Registration Statement, any New Registration Statement or any prospectus or for additional information.

(b) Amendments. The Company will prepare and file with the SEC any amendments, post-effective amendments or supplements to the Initial Registration Statement, any New Registration Statement or any related prospectus, as applicable, that, (a) may be necessary to keep such Registration Statement effective for the Registration Period and to comply with the provisions of the Securities Act and the Exchange Act with respect to the distribution of all of the Registrable Securities covered thereby, or (b) in the reasonable opinion of the Warrantholder and the Company, may be necessary or advisable in connection with any acquisition or sale of Registrable Securities by the Warrantholder.

(c) Warrantholder Review. The Company will not file any amendment or supplement to the Registration Statement, any New Registration Statement or any prospectus, other than documents incorporated by reference, relating to the Warrantholder, the Registrable Securities or the transactions contemplated hereby unless (A) the Warrantholder and their counsel shall have been advised and afforded the opportunity to review and comment thereon at least six (6) Business Days prior to filing with the SEC and (B) the Company shall have given reasonable due consideration to any comments thereon received from the Warrantholder or their counsel.

(d) Copies Available. The Company will furnish to the Warrantholder and its counsel copies of the Initial Registration Statement, any prospectus thereunder (including all documents incorporated by reference therein), any prospectus supplement thereunder, any New Registration Statement and all amendments to the Initial Registration Statement or any New Registration Statement that are filed with the SEC during the Registration Period (including all documents filed with or furnished to the SEC during such period that are deemed to be incorporated by reference therein), each letter written by or on behalf of the Company to the SEC or the staff of the SEC, and each item of correspondence from the SEC or the staff of the SEC, in each case relating to such Registration Statement (other than any portion thereof which contains information for which the Company has sought confidential treatment) and such other documents as the Warrantholder may reasonably request in order to facilitate the disposition of the Registrable Securities owned by the Warrantholder that are covered by such Registration Statement, in each case as soon as reasonably practicable upon the Warrantholder’s request and in such quantities as the Warrantholder may from time to time reasonably request; provided, however, that the Company shall not be required to furnish any document to the Warrantholder to the extent such document is available on EDGAR.

(e) Notification of Stop Orders; Material Changes. The Company shall use its reasonable best efforts to (i) prevent the issuance of any stop order or other suspension of effectiveness and, (ii) if such order is issued, obtain the withdrawal of any such order as soon as practicable. The Company shall advise the Warrantholder promptly (but in no event later than 48 hours) and shall confirm such advice in writing, in each case: (i) of the Company’s receipt of notice


of any request by the SEC or any other federal or state governmental authority for amendment of or a supplement to the Registration Statement or any prospectus or for any additional information; (ii) of the Company’s receipt of notice of the issuance by the SEC or any other federal or state governmental authority of any stop order suspending the effectiveness of the Initial Registration Statement or prohibiting or suspending the use of any prospectus or prospectus supplement, or any New Registration Statement, or of the Company’s receipt of any notification of the suspension of qualification of the Registrable Securities for offering or sale in any jurisdiction or the initiation or contemplated initiation of any proceeding for such purpose; and (iii) of the Company becoming aware of the happening of any event, which makes any statement of a material fact made in any Registration Statement or any prospectus untrue or which requires the making of any additions to or changes to the statements then made in any Registration Statement or any prospectus in order to state a material fact required by the Securities Act to be stated therein or necessary in order to make the statements then made therein (in the case of any prospectus, in light of the circumstances under which they were made) not misleading, or of the necessity to amend any Registration Statement or any prospectus to comply with the Securities Act or any other law. The Company shall not be required to disclose to the Warrantholder the substance of specific reasons of any of the events set forth in clause (i) to (iii) of the immediately preceding sentence (each, a “Suspension Event”), but rather, shall only be required to disclose that the event has occurred. If at any time the SEC, or any other federal or state governmental authority shall issue any stop order suspending the effectiveness of any Registration Statement or prohibiting or suspending the use of any prospectus or prospectus supplement, the Company shall use its reasonable best efforts to obtain the withdrawal of such order at the earliest practicable time. The Company shall furnish to the Warrantholder, without charge, a copy of any correspondence from the SEC or the staff of the SEC, or any other federal or state governmental authority to the Company or its representatives relating to the Initial Registration Statement, any New Registration Statement or any prospectus, or prospectus supplement as the case may be. In the event of a Suspension Event set forth in clause (iii) of the first sentence of this Section 3(e), the Company will use its commercially reasonable efforts to publicly disclose such event as soon as reasonably practicable, or otherwise resolve the matter such that sales under Registration Statements may resume; provided, however, that if the Company has a bona fide business purpose for not making such information public, the Company may suspend the use of all Registration Statements for up to sixty (60) consecutive calendar days; provided, further, that the Company may not suspend the use of all Registration Statements more than twice, or for more than ninety (90) total calendar days, in each case during any twelve-month period.

(f) Confirmation of Effectiveness. If reasonably requested by the Warrantholder at any time in respect of any Registration Statement, the Company shall deliver to the Warrantholder a written confirmation from Company’s counsel of whether or not the effectiveness of such Registration Statement has lapsed at any time for any reason (including, without limitation, the issuance of a stop order) and whether or not such Registration Statement is currently effective and available to the Company for sale of Registrable Securities.

(g) Listing. The Company shall use best efforts to cause all Registrable Securities covered by a Registration Statement to be listed on the Nasdaq Global Select Market.


(h) Compliance with Applicable Regulation. The Company shall otherwise use best efforts to comply with all applicable rules and regulations of the SEC under the Securities Act and the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, or any similar successor statute (the “Exchange Act”), including, without limitation, Rule 172 under the Securities Act, file any final prospectus, including any supplement or amendment thereof, with the SEC pursuant to Rule 424 under the Securities Act, promptly inform the Warrantholder in writing if, at any time during the Registration Period, the Company does not satisfy the conditions specified in Rule 172 and, as a result thereof, the Warrantholder is required to deliver a prospectus in connection with any disposition of Registrable Securities and take such other actions as may be reasonably necessary to facilitate the registration of the Registrable Securities hereunder.

(i) Blue-Sky. The Company shall use best efforts to register or qualify or cooperate with the Warrantholder and their counsel in connection with the registration or qualification of such Registrable Securities for the offer and sale under the securities or blue sky laws of such jurisdictions reasonably requested by the Warrantholder; provided, however, that the Company shall not be required in connection therewith or as a condition thereto to (i) qualify to do business in any jurisdiction where it would not otherwise be required to qualify but for this Section 3(i), (ii) subject itself to general taxation in any jurisdiction where it would not otherwise be so subject but for this Section 3(i), or (iii) file a general consent to service of process in any such jurisdiction.

(j) Rule 144. With a view to making available to the Warrantholder the benefits of Rule 144 (or its successor rule) and any other rule or regulation of the SEC that may at any time permit the Warrantholder to sell shares of Common Stock to the public without registration, the Company covenants and agrees to: (i) make and keep adequate current public information available, as those terms are understood and defined in Rule 144, until the earlier of (A) six (6) months after such date as all of the Registrable Securities may be sold without restriction by the holders thereof pursuant to Rule 144 or any other rule of similar effect or (B) such date as there are no longer Registrable Securities; (ii) file with the SEC in a timely manner all reports and other documents required of the Company under the Exchange Act; (iii) furnish electronically to the Warrantholder upon request, as long as the Warrantholder owns any Registrable Securities, (A) a written statement by the Company that it has complied with the reporting requirements of the Exchange Act, (B) a copy of or electronic access to the Company’s most recent Annual Report on Form 10-K or Quarterly Report on Form 10-Q, and (C) such other information as may be reasonably requested in order to avail the Warrantholder of any rule or regulation of the SEC that permits the selling of any such Registrable Securities without registration and (iv) provide any legal opinions reasonably necessary therefor.

(k) Cooperation. The Company shall cooperate with the Warrantholder to facilitate the timely preparation and delivery of certificates or uncertificated shares representing the Registrable Securities to be sold pursuant to such Registration Statement or Rule 144 free of any restrictive legends and representing such number of shares of Common Stock and registered in such names as the holders of the Registrable Securities may reasonably request to the extent permitted by such Registration Statement or Rule 144 to effect sales of Registrable Securities; for the avoidance of doubt, the Company may satisfy its obligations hereunder without issuing physical stock certificates through the use of The Depository Trust Company’s Direct Registration System.


(l) Transfer Agent. The Company shall use reasonable best efforts to cause the Company’s transfer agent to remove any restrictive legend from any Registrable Securities, as promptly as practicable following a request pursuant to Sections 3(j) and 3(k). In connection herewith, if required by the Company’s transfer agent, the Company will promptly cause an opinion of counsel as to the effectiveness of the Registration Statement or the satisfaction of conditions under Rule 144, as applicable, to be delivered to and maintained with its transfer agent, together with any other authorizations, certificates and directions required by the transfer agent which authorize and direct the transfer agent to issue such Registrable Securities without any such legend upon sale by the holder of such Registrable Securities.

4. OBLIGATIONS OF THE WARRANTHOLDER.

(a) Warrantholder Information. The Warrantholder shall provide a completed customary Investor Questionnaire in connection with the registration of the Registrable Securities. The Warrantholder will as promptly as practicable notify the Company of any material change in the information provided hereunder, other than changes in its ownership of Common Stock.

(b) Suspension of Sales. The Warrantholder agrees that, upon receipt of any notice from the Company of the existence of Suspension Event as set forth in Section 3(e), the Warrantholder will immediately discontinue disposition of Registrable Securities pursuant to any Registration Statement covering such Registrable Securities until the Warrantholder’s receipt of a notice from the Company confirming the resolution of such Suspension Event and that such dispositions may again be made.

(c) Warrantholder Cooperation. The Warrantholder agrees to cooperate with the Company as reasonably requested by the Company in connection with the preparation and filing of any amendments and supplements to any Registration Statement or New Registration Statement hereunder, unless Warrantholder has notified the Company in writing of its election to exclude all of its Registrable Securities from such Registration Statement.

5. EXPENSES OF REGISTRATION.

All Registration Expenses incurred in connection with registrations pursuant to this Agreement shall be borne by the Company. All Selling Expenses relating to securities registered on behalf of the Warrantholder shall be borne by the Warrantholder.

6. INDEMNIFICATION.

(a) To the fullest extent permitted by law, the Company will, and hereby does, indemnify, hold harmless and defend the Warrantholder and the members, the directors, officers, partners, employees, members, managers, agents, representatives and advisors of the Warrantholder and each Person, if any, who controls the Warrantholder within the meaning of the Securities Act or the Exchange Act (each, an “Indemnified Person”), against any losses, obligation, claims, damages, liabilities, contingencies, judgments, fines, penalties, charges, costs (including, without limitation, court costs and costs of preparation, reasonable and documented attorneys’ fees, amounts paid in settlement (with the prior consent of the Company, such consent not to be unreasonably withheld) or reasonable and documented expenses, (collectively, “Claims”)) reasonably incurred in investigating, preparing or defending any action, claim, suit, inquiry, proceeding, investigation or appeal taken from the foregoing by or before any court or governmental, administrative or other regulatory agency or body or the SEC, whether pending or


threatened, whether or not an indemnified party is or may be a party thereto (“Indemnified Damages”), to which any of them may become subject insofar as such Claims (or actions or proceedings, whether commenced or threatened, in respect thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement or omission or alleged omission of any material fact contained in any Registration Statement, any preliminary prospectus or final prospectus, or any amendment or supplement thereof, or (ii) any violation or alleged violation by the Company or any of its subsidiaries of the Securities Act, Exchange Act or any other state securities or other “blue sky” laws of any jurisdiction in which Registrable Securities are offered or any rule or regulation promulgated thereunder applicable to the Company or its agents and relating to action or inaction required of the Company in connection with such registration of the Registrable Securities (the matters in the foregoing clauses (i) and (ii) being, collectively, “Violations”). The Company shall reimburse each Indemnified Person promptly as such expenses are incurred and are due and payable, for any reasonable out-of-pocket legal fees or other reasonable and documented expenses incurred by them in connection with investigating or defending any such Claim. Notwithstanding anything to the contrary contained herein, the indemnification agreement contained in this Section 6(a): (A) shall not apply to a Claim by an Indemnified Person arising out of or based upon a Violation which occurs in reliance upon and in conformity with information furnished in writing to the Company by the Warrantholder or such Indemnified Person specifically for use in such Registration Statement or prospectus and was reviewed and approved in writing by the Warrantholder or such Indemnified Person expressly for use in connection with the preparation of any Registration Statement, any prospectus or any such amendment thereof or supplement thereto, if such in each case if the foregoing was timely made available by the Company; (B) with respect to any superseded prospectus, shall not inure to the benefit of any such Person from whom the Person asserting any such Claim purchased the Registrable Securities that are the subject thereof (or to the benefit of any other Indemnified Person) if the untrue statement or omission of material fact contained in the superseded prospectus was corrected in the revised prospectus, as then amended or supplemented, and the Indemnified Person was promptly advised in writing not to use the outdated, defective or incorrect prospectus prior to the use giving rise to a violation; (C) shall not be available to the extent such Claim is based on a failure of the Warrantholder to deliver, or cause to be delivered, if required the prospectus to the Persons asserting an untrue statement or omission or alleged untrue statement or omission at or prior to the written confirmation of the sale of Registrable Securities; and (D) shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written consent of the Company, which consent shall not be unreasonably withheld. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of the Indemnified Person and shall survive the transfer of the Registrable Securities by the Warrantholder pursuant to Section 8.

(b) In connection with the Initial Registration Statement, any New Registration Statement or any prospectus, the Warrantholder agrees to indemnify, hold harmless and defend, the Company, each of its directors, each of its officers who signed the Initial Registration Statement or signs any New Registration Statement, each Person, if any, who controls the Company within the meaning of the Securities Act or the Exchange Act (collectively and together with an Indemnified Person, an “Indemnified Party”), against any Claim or Indemnified Damages resulting from any Violation, in each case to the extent, and only to the extent, that such Violation occurs in reliance upon and in conformity with information about the Warrantholder furnished in writing by the Warrantholder to the Company and reviewed and approved in writing by the


Warrantholder or such Indemnified Person expressly for use in connection with the preparation of the Registration Statement, any New Registration Statement, any prospectus or any such amendment thereof or supplement thereto. In no event shall the liability of the Warrantholder be greater in amount than the dollar amount of the proceeds (net of all expense paid by the Warrantholder in connection with any claim relating to this Section 6 and the amount of any damages the Warrantholder has otherwise been required to pay by reason of such untrue statement or omission) received by the Warrantholder upon the sale of the Registrable Securities included in such Registration Statement giving rise to such indemnification obligation. Subject to Section 6(d) hereof, the Warrantholder will reimburse any reasonable out-of-pocket legal or other documented expenses reasonably incurred by them in connection with investigating or defending any such Claim; provided, however, that the indemnity agreement contained in this Section 6(b) and the agreement with respect to contribution contained in Section 7 shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written consent of the Warrantholder (which consent shall not be unreasonably conditioned or withheld). Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of such Indemnified Party and shall survive the transfer of the Registrable Securities by the Warrantholder pursuant to Section 8.

(c) Promptly after receipt by an Indemnified Person or Indemnified Party under this Section 6 of notice of the commencement of any action or proceeding (including any governmental action or proceeding) involving a Claim, such Indemnified Person or Indemnified Party shall, if a Claim in respect thereof is to be made against any indemnifying party under this Section 6, deliver to the indemnifying party a written notice of the commencement thereof, and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to assume control of the defense thereof with counsel mutually satisfactory to the indemnifying party and the Indemnified Person or the Indemnified Party, as the case may be, and upon such notice, the indemnifying party shall not be liable to the Indemnified Person or the Indemnified Party for any legal or other expenses subsequently incurred by the Indemnified Person or the Indemnified Party in connection with the defense thereof; provided, however, that an Indemnified Person or Indemnified Party (together with all other Indemnified Persons and Indemnified Parties that may be represented without conflict by one counsel) shall have the right to retain its own counsel with the reasonable fees and expenses to be paid by the indemnifying party, if, in the reasonable opinion of counsel retained by the indemnifying party, the representation by such counsel of the Indemnified Person or Indemnified Party and the indemnifying party would be inappropriate due to actual or potential differing interests between such Indemnified Person or Indemnified Party and any other party represented by such counsel in such proceeding. The Indemnified Party or Indemnified Person shall cooperate with the indemnifying party in connection with any negotiation or defense of any such action or claim by the indemnifying party and shall furnish to the indemnifying party all information reasonably available to the Indemnified Party or Indemnified Person which relates to such action or claim. The indemnifying party shall keep the Indemnified Party or Indemnified Person fully apprised as to the status of the defense or any settlement negotiations with respect thereto. No indemnifying party shall be liable for any settlement of any action, claim or proceeding effected without its written consent, provided, however, that the indemnifying party shall not unreasonably withhold, delay or condition its consent. No indemnifying party shall, without the consent of the Indemnified Party or Indemnified Person, consent to entry of any judgment or enter into any settlement or other compromise which does not include as an unconditional term thereof


the giving by the claimant or plaintiff to such Indemnified Party or Indemnified Person of a release from all liability in respect to such claim or litigation. Following indemnification as provided for hereunder, the indemnifying party shall be subrogated to all rights of the Indemnified Party or Indemnified Person with respect to all third parties, firms or corporations relating to the matter for which indemnification has been made. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action shall not relieve such indemnifying party of any liability to the Indemnified Person or Indemnified Party under this Section 6, except to the extent that the indemnifying party is prejudiced in its ability to defend such action.

(d) The indemnification required by this Section 6 shall be made by periodic payments of the amount thereof during the course of the investigation or defense, as and when bills are received or Indemnified Damages are incurred. Any Person receiving a payment pursuant to this Section 6 which person is later determined to not be entitled to such payment shall return such payment (including reimbursement of expenses) to the person making it.

(e) The indemnity agreements contained herein shall be in addition to (i) any cause of action or similar right of the Indemnified Party or Indemnified Person against the indemnifying party or others, and (ii) any liabilities the indemnifying party may be subject to pursuant to the law.

7. CONTRIBUTION.

To the extent any indemnification by an indemnifying party is prohibited or limited by law, the indemnifying party agrees to make the maximum contribution with respect to any amounts for which it would otherwise be liable under Section 6 to the fullest extent permitted by law; provided, however, that: (i) no seller of Registrable Securities guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any seller of Registrable Securities who was not guilty of fraudulent misrepresentation; and (ii) contribution by any seller of Registrable Securities shall be limited in amount to the net amount of proceeds (net of all expenses paid by such holder in connection with any claim relating to Section 6 and the amount of any damages such holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission) received by such seller from the sale of such Registrable Securities giving rise to such contribution obligation.

8. ASSIGNMENT OF REGISTRATION RIGHTS.

The Company shall not assign this Agreement or any rights or obligations hereunder (whether by operation of law or otherwise) without the prior written consent of the Warrantholder; provided, however, that in any transaction, whether by merger, reorganization, restructuring, consolidation, financing or otherwise, whereby the Company is a party and in which the Registrable Securities are converted into the equity securities of another Person, from and after the effective time of such transaction, such Person shall, by virtue of such transaction, be deemed to have assumed the obligations of the Company hereunder, the term “Company” shall be deemed to refer to such Person and the term “Registrable Securities” shall be deemed to include the securities received by the Warrantholder in connection with such transaction unless such securities are otherwise freely tradable by the Warrantholder after giving effect to such transaction, and the prior


written consent of the Warrantholder shall not be required for such transaction. The Warrantholder may not assign its rights under this Agreement without the prior written consent of the Company; provided, that the Warrantholder may assign, without the prior written consent of the Company, all or a portion of its rights hereunder to either (x) a Permitted Warrantholder Transferee or (y) to any other Person in connection with any transfer of Warrants or Registerable Securities (made in accordance with the terms of the Warrant Issuance Agreement and the Warrants) if, immediately following such transfer, such Person would hold Registerable Securities (for the avoidance of doubt, after giving effect to the full exercise of any Warrants included in such transfer) equal to no less than 25% of the total Registerable Securities then subject to this Agreement. The provisions of this Agreement shall be binding upon and inure to the benefit of the Warrantholder and its successors and permitted assigns.

9. AMENDMENTS AND WAIVERS.

The provisions of this Agreement, including the provisions of this sentence, may be amended, modified or supplemented, or waived only by a written instrument executed by the Company and the Warrantholder.

10. MISCELLANEOUS.

(a) Notices. Any notices or other communications required or permitted to be given hereunder shall be in writing in the English language and shall be deemed to be given (a) when delivered if personally delivered to the party for whom it is intended, (b) when delivered, if sent by electronic mail during normal business hours of the recipient, and if not sent during normal business hours, then on the recipient’s next Business Day, (c) three (3) calendar days after having been sent by certified or registered mail, return-receipt requested and postage prepaid, or (d) one (1) Business Day after deposit with a nationally recognized overnight courier, freight prepaid, specifying next Business Day delivery, with written verification of receipt:

 

i. If to the Company, addressed as follows:

Attention:

   IO Biotech, Inc.

Address:

   IO Biotech, Inc.
   Ole Maaløes Vej 3
   DK-2200 Copenhagen N
   Denmark


with copies (which shall not constitute notice) to:

Attention:

   Devin Smith
   General Counsel

Address:

   IO Biotech, Inc.
  

430 E 29th St

Suite 940

New York, NY 10016

USA

and: 

  

Attention:

   Frank Rahmani

Address:

   Sidley Austin LLP
   1001 Page Mill Rd., Building 1
   Palto Alto, California 94304
   USA

Email:

   frahmani@sidley.com
ii. If to the Warrantholder, addressed as follows:

Attention:

   OPS/EGPF/2-EGILS/[LSB]/[SI]

Address:

   The and: European Investment Bank
   100 boulevard Konrad Adenauer
   L-2950 Luxembourg
with a copy (which shall not constitute notice) to:

Attention:

   Matthew K. Warner
   Partner

Address:

   Clifford Chance US LLP
   Two Manhattan West
   375 9th Avenue
   New York, NY 10019
   USA

Email:

   matthew.warner@cliffordchance.com

Any Person may change the address to which notices and communications to it are to be addressed by notification as provided for herein.

(b) No Waiver. No waiver of any provision in this Agreement shall be effective without the written consent of the waiving party. No failure or delay on the part of either party hereto in the exercise of any power, right or privilege under this Agreement shall operate as a waiver thereof, nor shall any single or partial exercise of any such power, right or privilege preclude any other or further exercise thereof or of any other right, power or privilege.


(c) Governing Law; Jurisdiction; Waiver of Trial by Jury; Remedies.

(i) This Agreement and any non-contractual obligations arising out of or in connection with it shall be governed by and construed in accordance with the laws of the State of New York, without regard to any to principles of conflicts or choice of law in the State of New York or in any other state.

(ii) Each of the parties hereto irrevocably and unconditionally submits, for itself and its property, to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan, in any action or proceeding arising out of or relating to this Agreement for recognition or enforcement of any judgment, and each of the parties hereto irrevocably and unconditionally agrees, to the fullest extent permitted by Applicable Law, that all claims in respect of any such action or proceeding may be heard and determined in such state or federal court sitting in the City of New York in the Borough of Manhattan. Each of the parties hereto agrees that a final judgment in any such action or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by law.

(iii) EACH OF THE PARTIES TO THIS AGREEMENT IRREVOCABLY AND UNCONDITIONALLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY RIGHT IT MAY HAVE TO TRIAL BY JURY IN RESPECT OF ANY LEGAL ACTION OR LITIGATION ARISING OUT OF, OR IN CONNECTION WITH, OR RELATING TO, THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY, IN EACH CASE WHETHER NOW EXISTING OR HEREAFTER ARISING, AND WHETHER IN CONTRACT, TORT, EQUITY, OR OTHERWISE.

(iv) The Warrantholder, in addition to being entitled to exercise all rights granted by Applicable Law, including recovery of damages, will be entitled to specific performance of its rights under this Agreement. The Company agrees that monetary damages would not be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Agreement, and hereby agrees to waive and not to assert the defense in any action for specific performance that a remedy at law would be adequate.

(d) Integration. This Agreement, the Finance Contract, the Warrant Issuance Agreement and the other Finance Documents constitute the entire understanding among the parties hereto with respect to the subject matter hereof and thereof. There are no restrictions, promises, warranties or undertakings, other than those set forth or referred to herein and therein. This Agreement, the Finance Contract, the Warrant Issuance Agreement and the other Finance Documents supersede all other prior oral or written agreements between the Warrantholder, the Company, their Affiliates and Persons acting on their behalf with respect to the subject matter hereof and thereof.

(e) No Third Party Beneficiaries. This Agreement is intended for the benefit of the parties hereto and their respective permitted successors and assigns, and is not for the benefit of, nor may any provision hereof be enforced by, any other Person. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. Subject to the requirements of Section 8, this Agreement shall inure to the benefit of and be binding upon the permitted successors and assigns of each of the parties hereto.


(f) Headings. The titles, subtitles and headings in this Agreement are for convenience of reference and shall not form part of, or affect the interpretation of, this Agreement.

(g) Counterparts. This Agreement may be executed in two or more identical counterparts, all of which shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other party; provided that a facsimile or pdf signature including any electronic signatures complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com shall be considered due execution and shall be binding upon the signatory thereto with the same force and effect as if the signature were an original, not a facsimile or pdf (or other electronic reproduction of a) signature.

(h) Further Assurances. Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents as the other party may reasonably request in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby.

(i) No Strict Construction; Mutual Drafting. The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent and no rules of strict construction will be applied against any party. This Agreement is the joint product of the Warrantholder and the Company and each provision hereof has been subject to the mutual consultation, negotiation and agreement of such parties and shall not be construed for or against any party hereto.

(j) Severability. Any provision of this Agreement that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof but shall be interpreted as if it were written so as to be enforceable to the maximum extent permitted by applicable law, and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. To the extent permitted by applicable law, the parties hereby waive any provision of law which renders any provisions hereof prohibited or unenforceable in any respect.

(k) Non-Recourse. Notwithstanding anything that may be expressed or implied in this Agreement, the Company covenants, agrees and acknowledges that no recourse under this Agreement or any documents or instruments delivered in connection with this Agreement shall be had against any current or future director, officer, employee, stockholder, general or limited partner or member of the Warrantholder or of any affiliates or assignees thereof, whether by the enforcement of any assessment or by any legal or equitable proceeding, or by virtue of any statute, regulation or other applicable law, it being expressly agreed and acknowledged that no personal liability whatsoever shall attach to, be imposed on or otherwise be incurred by any current or future director, officer, employee, stockholder, general or limited partner or member of the Warrantholder or of any affiliates or assignees thereof, as such for any obligation of the Warrantholder under this Agreement or any documents or instruments delivered in connection with this Agreement for any claim based on, in respect of or by reason of such obligations or their creation.


(l) Cumulative Remedies. The remedies provided herein are cumulative and not exclusive of any remedies provided by law.

[Signature Page Follows]


IN WITNESS WHEREOF, the parties have caused this Registration Rights Agreement to be duly executed as of date first written above.

 

COMPANY:
IO BIOTECH, INC.
By:  

/s/ Mai-Britt Zocca

  Name: Mai-Britt Zocca
  Title: Chief Executive Officer

[Signature Page to Registration Rights Agreement]


WARRANTHOLDER:
THE EUROPEAN INVESTMENT BANK
By:  

/s/ Maria-Teresa MASSAAD

  Name: Maria-Teresa MASSAAD
  Title: Head of Division
By:  

/s/ Yu ZHANG

  Name: Yu ZHANG
  Title: Head of Division

[Signature Page to Registration Rights Agreement]

Exhibit 99.1

 

LOGO

IO Biotech secures up to €57.5 million in debt financing from the European Investment Bank

- Funds expected to be used to advance IO Biotech’s immune-modulating therapeutic cancer vaccines, including potential BLA submission for IO102-IO103 in 2025

- Commitment is part of the European Investment Bank’s strategy to support biotech companies with cutting-edge expertise in therapeutic areas such as immuno-oncology

- Debt facility expected to extend company’s cash runway into the second quarter of 2026

Copenhagen, Denmark and New York, NY – December 20, 2024: IO Biotech (Nasdaq: IOBT), a clinical-stage biopharmaceutical company developing novel, immune-modulating, off-the-shelf therapeutic cancer vaccines today announced that it has entered into a loan facility of up to €57.5 million from the European Investment Bank (EIB), the long-term lending institution of the European Union owned by its Member States. The debt facility includes three committed tranches totaling up to €37.5 million, which will become available if the company satisfies certain conditions, and one uncommitted accordion tranche of €20 million. The company expects the first two tranches to be available for disbursement in the first quarter of 2025.

Amy Sullivan, Chief Financial Officer of IO Biotech, commented, “The support from the EIB, which is provided on favorable terms, will help fund the continued development and pre-commercialization of IO102-IO103 and other therapeutic cancer vaccine candidates generated from our T-Win® platform. We expect that the capital drawn from the three committed tranches of the EIB debt facility will extend our cash runway into the second quarter of 2026.”

The loan facility is unsecured has no minimum cash covenants and consists of three committed tranches of €10.0 million (Tranche A), €12.5 million (Tranche B), and €15.0 million (Tranche C) totaling €37.5 million, and one uncommitted accordion tranche of €20.0 million. Each committed tranche will become available if the company satisfies certain conditions precedent. The company expects funds from Tranches A and B to be available in the first quarter of 2025. The company has 36 months to satisfy the conditions for Tranche C, which include raising an additional $50 million in cash and submitting an application for marketing authorization for IO102-IO103 in the U.S. or the EU. In addition, as a condition for disbursement of each Tranche of the loan facility, the company has agreed to issue to the EIB warrants to purchase a number of shares of the company’s common stock determined by a formula set forth in a warrant issuance agreement. Each tranche has a maturity of 6 years from its disbursement. The loan is structured with capitalized interest and payment deferred to maturity of each tranche.


LOGO

 

Van Lanschot Kempen served as financial advisor to the company and Kromann Reumert and Sidley Austin LLP acted as legal counsel to the company.

About IO102-IO103

IO102-IO103 is an investigational, immune-modulatory, off-the-shelf therapeutic cancer vaccine designed to kill both tumor cells and immune-suppressive cells in the tumor microenvironment (TME) by stimulating activation and expansion of T cells against indoleamine 2,3-dioxygenase (IDO1) positive and/or programmed death-ligand 1 (PD-L1) positive cells. Based on positive Phase 1/2 first line metastatic melanoma data, IO102-IO103, in combination with pembrolizumab, has been granted a Breakthrough Therapy Designation for the treatment of advanced melanoma by the US Food and Drug Administration. The company is currently conducting a pivotal Phase 3 trial (IOB-013/KN-D18; NCT05155254) investigating IO102-IO103 in combination with pembrolizumab versus pembrolizumab alone in patients with advanced melanoma, a Phase 2 basket trial (IOB-022/KN-D38; NCT05077709) investigating IO102-IO103 in combination with pembrolizumab as first line treatment in patients with advanced solid tumors, and a Phase 2 basket trial (IOB-032/PN-E40; NCT05280314) investigating IO102-IO103 in combination with pembrolizumab as neo-adjuvant/adjuvant treatment of patients with solid tumors.

The clinical trials are sponsored by IO Biotech and conducted in collaboration with Merck, which is supplying pembrolizumab. IO Biotech maintains global commercial rights to IO102-IO103.

KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.

About IO Biotech

IO Biotech is a clinical-stage biopharmaceutical company developing novel, immune-modulating therapeutic cancer vaccines based on its T-win® platform. The T-win platform is based on a novel approach to cancer vaccines designed to activate T cells to target the immunosuppressive cells in the tumor microenvironment. IO Biotech is advancing its lead cancer vaccine candidate, IO102-IO103, in clinical trials, and additional pipeline candidates through preclinical development. IO Biotech is headquartered in Copenhagen, Denmark and has US headquarters in New York, New York.

For further information, please visit www.iobiotech.com. Follow us on our social media channels on LinkedIn and X (@IOBiotech).

About the European Investment Bank

The European Investment Bank (EIB) is the long-term lending institution of the European Union owned by its Member States. It makes long-term finance available for sound investment in order to contribute towards EU policy goals.


LOGO

 

Forward-Looking Statement

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements, including regarding satisfaction of conditions precedent for disbursements from the loan facility, the timing or outcome of primary analysis of the company’s Phase 3 trial, other current or future clinical trials, their progress, enrollment or results, expectations regarding receipt of, and expected purposes for, committed and uncommitted funding provided by the EIB, or the company’s financial position or cash runway, are based on IO Biotech’s current assumptions and expectations of future events and trends, which affect or may affect its business, strategy, operations or financial performance, and actual results and other events may differ materially from those expressed or implied in such statements due to numerous risks and uncertainties. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Because forward-looking statements are inherently subject to risks and uncertainties, you should not rely on these forward-looking statements as predictions of future events. These forward-looking statements speak only as of the date hereof and should not be unduly relied upon. Except to the extent required by law, IO Biotech undertakes no obligation to update these statements, whether as a result of any new information, future developments or otherwise.

Contact:

Investors

Maryann Cimino, Director of Investor Relations

IO Biotech, Inc.

617-710-7305

mci@iobiotech.com

Media

Julie Funesti

Salutem

917-498-1967

Julie.Funesti@salutemcomms.com

v3.24.4
Document and Entity Information
Dec. 19, 2024
Cover [Abstract]  
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Entity Central Index Key 0001865494
Document Type 8-K
Document Period End Date Dec. 19, 2024
Entity Registrant Name IO Biotech, Inc.
Entity Incorporation State Country Code DE
Entity File Number 001-41008
Entity Tax Identification Number 87-0909276
Entity Address, Address Line One Ole Maaløes Vej 3
Entity Address, Postal Zip Code DK-2200
Entity Address, City or Town Copenhagen N
Entity Address, Country DK
City Area Code +45
Local Phone Number 7070 2980
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Soliciting Material false
Pre Commencement Tender Offer false
Pre Commencement Issuer Tender Offer false
Security 12b Title Common Stock, par value $0.001 per share
Trading Symbol IOBT
Security Exchange Name NASDAQ
Entity Emerging Growth Company true
Entity Ex Transition Period false

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