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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): August 14, 2023
JAGUAR HEALTH, INC.
(Exact name of registrant as specified in its charter)
Delaware |
001-36714 |
46-2956775 |
(State or other jurisdiction of incorporation) |
(Commission File Number) |
(IRS Employer Identification No.) |
200 Pine Street, Suite 400
San Francisco, California |
94104 |
(Address of principal executive offices) |
(Zip Code) |
Registrant’s telephone number, including
area code: (415) 371-8300
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
¨ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
¨ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
¨ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
¨ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ¨
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
Trading Symbol(s) |
Name of each exchange on which registered |
Common Stock, Par Value $0.0001 Per Share |
JAGX |
The Nasdaq Capital Market |
Item 2.02 Results of Operations and Financial Conditions.
On August 14, 2023, Jaguar Health, Inc. (the “Company”)
issued a press release announcing second quarter 2023 results. A copy of this press release is furnished as Exhibit 99.1 to this report.
The information in Item 2.02 and the press release furnished as Exhibit
99.1 hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), or otherwise subject to the liabilities of that section, or incorporated by reference into any of the Company’s
filings under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference
in any such filing.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits
104 |
|
Cover Page Interactive Data File (embedded with the inline XBRL document) |
SIGNATURES
Pursuant to the requirements of the Securities
Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly
authorized.
|
JAGUAR HEALTH, INC. |
|
|
|
By: |
/s/ Lisa A. Conte |
|
|
Name: |
Lisa A. Conte |
|
|
Title: |
President and Chief Executive Officer |
Date: August 14, 2023
Exhibit
99.1
Jaguar Health
Reports Second Quarter 2023 Financial Results
Net revenue increased
36% in Q2 2023 versus Q1 2023
Top line results
expected late October 2023 for company’s phase 3 OnTarget trial of crofelemer for preventative treatment of cancer therapy-related
diarrhea
Jaguar is supporting
investigator-initiated proof-of-concept studies of crofelemer for the rare disease indications of short bowel syndrome and microvillus
inclusion disease in the EU and Middle East/North Africa regions, with results expected before the end of 2023 and in 2024
REMINDER:
Jaguar to host investor webcast Monday, August 14th at 8:30 a.m. Eastern regarding Q2 2023 financials and company
updates; Click here to register for webcast
SAN FRANCISCO, CA / August 14, 2023
/ Jaguar Health, Inc. (NASDAQ: JAGX) (“Jaguar” or the “Company”) today reported consolidated second-quarter
2023 financial results and provided Company updates.
The combined net revenue for Mytesi® (crofelemer) and
the Company’s crofelemer prescription product for treatment of chemotherapy-induced diarrhea in dogs, Canalevia®-CA1,
which became commercially available in April 2022, was approximately $2.7 million in the second quarter of 2023, representing an increase
of 36% compared to prescription product net revenue in the first quarter of 2023, which totaled approximately $2.0 million, and a decrease
of approximately 8% over prescription product net revenue in the second quarter of 2022, which totaled approximately $2.9 million. The
loss from operations increased by $1.6 million, from $6.4 million in the quarter ended June 30, 2022 to $8.1 million during the same period
in 2023.
Lisa Conte, Jaguar's president and CEO,
said, “Our paramount near-term clinical activity is our Phase 3 pivotal OnTarget trial of Mytesi for the follow-on
indication of the preventative treatment of chemotherapy-induced overactive bowel (CIOB) – which includes symptoms such as chronic
debilitating diarrhea, GI urgency, and GI incontinence. We have completed patient enrollment for OnTarget – a key step on our journey
to making crofelemer available to treat the neglected comorbidity of CIOB – and top line results from this pivotal study are expected
in late October 2023. With success, we expect to expand the indication of Mytesi in 2024.”
Jaguar is supporting investigator-initiated and investigator IND proof-of-concept
studies of crofelemer for microvillus inclusion disease (MVID) and short bowel syndrome (SBS) with intestinal failure in the US, EU and
Middle East/North Africa (MENA) regions, with results expected before the end of 2023 and in 2024. In accordance with the guidelines of
specific EU countries, published data from such clinical investigations could support reimbursed early patient access to crofelemer for
SBS or MVID, potentially in 2024, for these debilitating conditions.
MVID, an ultra-rare pediatric congenital diarrheal disorder (CDD),
and SBS with intestinal failure are Jaguar’s two prioritized rare disease investigative indications for a novel formulation of crofelemer.
MVID is a catastrophic medical situation for pediatric patients, and there are currently no approved drug treatments. The Company’s
Investigational New Drug application for crofelemer for the treatment of MVID was activated by the U.S. Food and Drug Administration (FDA)
August 7, 2023.
Crofelemer has been granted Orphan Drug
Designation (ODD) by the FDA and the European Medicines Agency (EMA) for both MVID and SBS with intestinal failure. The ODD programs
in the U.S. and European Union qualify sponsors to receive potential incentives to develop therapies for the diagnosis, prevention, or
treatment of rare diseases or conditions.
2023 SECOND QUARTER COMPANY FINANCIAL
RESULTS:
· | Net
Mytesi Revenue: Net revenue for Mytesi was approximately $2.6 million in the second quarter
of 2023, representing an increase of 36% compared to Mytesi net revenue in the first quarter
of 2023, which totaled approximately $2.0 million, and a decrease of approximately 7.0% over
Mytesi net revenue in the second quarter of 2022, which totaled approximately $2.8 million. |
· | Mytesi
Prescription Volume: Mytesi prescription volume increased approximately 4.0% in the second
quarter of 2023 compared to the first quarter of 2023, and decreased approximately 4.5% in
the second quarter of 2023 compared to the second quarter of 2022. Prescription volume differs
from invoiced sales volume, which reflects, among other factors, varying buying patterns
among specialty pharmacies in the closed network as they manage their inventory levels. |
| · | Net Canalevia-CA1 Revenue: Net revenue for the Company’s crofelemer prescription product for treatment of chemotherapy-induced
diarrhea in dogs, Canalevia-CA1, which became commercially available in April 2022, was approximately $39,100 in the second quarter of
2023, representing an increase of 40% over Canalevia-CA1 net revenue in the first quarter of 2023, which totaled approximately $27,820. |
| · | Neonorm™: Revenues for the non-prescription
Neonorm products for calves and foals and Jaguar’s Animal Health business unit were minimal for the second quarters of 2023 and
2022, in accordance with the Company’s primary focus on human health and prescription products. |
| |
Three Months Ended | | |
| | |
| |
Financial Highlights | |
June 30, | | |
| | |
| |
(in thousands, except per share amounts) | |
2023 | | |
2022 | | |
$ change | | |
% change | |
| |
| | |
| | |
| | |
| |
Net product revenue | |
$ | 2,676 | | |
$ | 2,921 | | |
| (245 | ) | |
| -8 | % |
Loss from operations | |
$ | (8,102 | ) | |
$ | (6,479 | ) | |
| (1,623 | ) | |
| 25 | % |
Net loss attributable to shareholders | |
$ | (12,150 | ) | |
$ | (9,367 | ) | |
| (2,783 | ) | |
| 30 | % |
Net loss per share, basic | |
$ | (0.69 | ) | |
$ | (0.12 | ) | |
| (0.57 | ) | |
| 475 | % |
Net loss per share, diluted | |
$ | (0.42 | ) | |
$ | (0.12 | ) | |
| (0.30 | ) | |
| 250 | % |
| · | Cost of Product Revenue: Total cost of product revenue increased by
approximately $35,000, from $456,000 for the quarter ended June 30, 2022 to $491,000 for the quarter ended June 30, 2023. This was due
to increased direct labor for QA personnel in Q2 2023 compared to Q2 2022. |
· | Research
and Development: The R&D expense increased by $1.8 million, from $2.5 million for
the quarter ended June 30, 2022 to $4.3 million during the same quarter in 2023 primarily
due to an increase related to the Phase 3 clinical
trial and regulatory initiatives for OnTarget trial and other initiatives. |
| · | Sales and Marketing: The Sales and Marketing expense decreased by
approximately $0.5 million, from $2.1 million for the quarter ended June 30, 2022 to $1.6 million during the same quarter in 2023. Direct
marketing fees and expenses decreased due to savings associated with the utilization of a more cost-effective patient support services
vendor, other Mytesi marketing initiatives, as well as decreased stock-based compensation, and commission expenses. |
· | General
and Administrative: The G&A expense increased by $0.1 million, from $4.3 million
for the quarter ended June 30, 2022, to $4.4 million during the same quarter in 2023. The
increase of $0.1 million was largely due to increased travel expenses as travel restrictions
from the pandemic have abated. |
· | Loss
from Operations: Loss from operations increased by $1.6 million, from $6.5 million in the quarter ended June 30, 2022 to $8.1 million
during the same period in 2023. |
· | Net
Loss: Net loss attributable to common shareholders increased by approximately $2.8 million, from $9.4 million in the quarter ended
June 30, 2022 to $12.2 million in the same period in 2023. In addition to the loss from operations: |
| · | Interest
expense increased by $1.0 million from $2.5 million in the quarter ended June 30, 2022 to
$3.5 million for the same period in 2023 primarily due to interest from the royalty and note
agreements. |
| · | Change
in fair value of financial instrument and hybrid instrument designated at Fair Value Option
(“FVO") decreased $1.5 million from a gain of approximately $0.8 million for the
three months ended June 30, 2022 to a loss of about $0.7 million for the same period in 2023
primarily due to fair value adjustments in liability classified warrants and notes payable
designated at FVO. |
| · | Other
expenses decreased by about $1.1 million from the quarter ended June 30, 2022 to the same
period in 2023 largely due to foreign currency transactions. |
· | Non-GAAP
Recurring EBITDA: Non-GAAP recurring EBITDA for the second quarter of 2023 and the second
quarter of 2022 were a net loss of $7.8 million and $5.3 million, respectively. |
| |
Three Months Ending | |
| |
June 30, | |
(in thousands) | |
2023 | | |
2022 | |
| |
| | |
| |
| |
(unaudited) | |
Net loss attributable to common shareholders | |
$ | (12,150 | ) | |
$ | (9,367 | ) |
Adjustments: | |
| | | |
| | |
Interest expense | |
| 3,453 | | |
| 2,536 | |
Property and equipment depreciation | |
| 20 | | |
| 10 | |
Amortization of intangible assets | |
| 484 | | |
| 422 | |
Share-based compensation expense | |
| 529 | | |
| 1,113 | |
Income taxes | |
| - | | |
| - | |
Non-GAAP EBITDA | |
| (7,665 | ) | |
| (5,286 | ) |
Impairment of indefinite-lived intangible assets | |
| | | |
| | |
Loss on extinguishment of debt | |
| - | | |
| - | |
Non-GAAP Recurring EBITDA | |
$ | (7,665 | ) | |
$ | (5,286 | ) |
Note Regarding Use of Non-GAAP Measures
The Company supplements its
condensed consolidated financial statements presented on a GAAP basis by providing non-GAAP EBITDA and non-GAAP recurring EBITDA,
which are considered non-GAAP under applicable SEC rules. Jaguar believes that the disclosure items of these non-GAAP measures
provide investors with additional information that reflects the basis upon which Company management assesses and operates the
business. These non-GAAP financial measures are not in accordance with GAAP and should not be viewed in isolation or as substitutes
for GAAP net sales and GAAP net loss and are not substitutes for, or superior to, measures of financial performance in conformity
with GAAP.
The Company defines non-GAAP EBITDA
as net loss before interest expense and other expense, depreciation of property and equipment, amortization of intangible assets, share-based
compensation expense and provision for or benefit from income taxes. The Company defines non-GAAP Recurring EBITDA as non-GAAP EBITDA
adjusted for certain non-recurring revenues and expenses. Company management believes that non-GAAP EBITDA and non-GAAP Recurring EBITDA
are meaningful indicators of Jaguar’s performance and provide useful information to investors regarding the Company’s results
of operations and financial condition.
Participation
Instructions for Webcast
When: Monday, August
14, 2023, at 8:30 AM Eastern Time
Participant Registration
& Access Link: Click Here
Replay Instructions
for Webcast
Replay of the webcast
on the investor relations section of Jaguar’s website: (click here)
About Crofelemer
Crofelemer
is the only oral FDA approved prescription drug under botanical guidance. It is plant-based, extracted and purified from the red bark
sap of the Croton lechleri tree in the Amazon Rainforest. Jaguar family company Napo Pharmaceuticals has established a sustainable
harvesting program, under fair trade practices, for crofelemer to ensure a high degree of quality, ecological integrity, and support for
Indigenous communities.
About the Jaguar Health Family of
Companies
Jaguar Health, Inc. (Jaguar) is a commercial
stage pharmaceuticals company focused on developing novel proprietary prescription medicines sustainably derived from plants from rainforest
areas for people and animals with GI distress, specifically overactive bowel, which includes symptoms such as chronic debilitating diarrhea,
GI urgency, and GI incontinence. Jaguar family company Napo Pharmaceuticals focuses on developing and commercializing human prescription
pharmaceuticals. Napo Pharmaceuticals’ crofelemer drug product candidate is the subject of the OnTarget study, an ongoing
pivotal Phase 3 clinical trial for preventative treatment of chemotherapy-induced overactive bowel (CIOB) in adults with cancer on targeted
therapy. Jaguar family company Napo Therapeutics is an Italian corporation Jaguar established in Milan, Italy in 2021 focused on expanding
crofelemer access in Europe and specifically for rare diseases. Jaguar Animal Health is a Jaguar tradename. Magdalena Biosciences, a
joint venture formed by Jaguar and Filament Health Corp., is focused on developing novel prescription medicines derived from plants for
mental health indications.
For more information about Jaguar Health,
please visit https://jaguar.health. For more information about Napo Pharmaceuticals, visit www.napopharma.com. For more
information about Napo Therapeutics, visit napotherapeutics.com. For more information about Magdalena Biosciences, visit magdalenabiosciences.com.
About Mytesi®
Mytesi (crofelemer) is an
antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral
therapy (ART). Mytesi is not indicated for the treatment of infectious diarrhea. Rule out infectious etiologies of diarrhea before
starting Mytesi. If infectious etiologies are not considered, there is a risk that patients with infectious etiologies will not
receive the appropriate therapy and their disease may worsen. In clinical studies, the most common adverse reactions occurring at a
rate greater than placebo were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and
increased bilirubin (3.1%).
See full Prescribing Information at
Mytesi.com. Crofelemer, the active ingredient in Mytesi, is a botanical (plant-based) drug extracted and purified from the red
bark sap of the medicinal Croton lechleri tree in the Amazon rainforest. Napo has established a sustainable harvesting program
for crofelemer to ensure a high degree of quality and ecological integrity.
Important Safety Information About
Canalevia®-CA1
For oral use in dogs only. Not for use
in humans. Keep Canalevia-CA1 (crofelemer delayed-release tablets) in a secure location out of reach of children and other animals. Consult
a physician in case of accidental ingestion by humans. Do not use in dogs that have a known hypersensitivity to crofelemer. Prior to
using Canalevia-CA1, rule out infectious etiologies of diarrhea. Canalevia-CA1 is a conditionally approved drug indicated for the treatment
of chemotherapy-induced diarrhea in dogs. The most common adverse reactions included decreased appetite, decreased activity, dehydration,
abdominal pain, and vomiting.
Caution: Federal law restricts
this drug to use by or on the order of a licensed veterinarian. Use only as directed. It is a violation of Federal law to use this
product other than as directed in the labeling. Conditionally approved by FDA pending a full demonstration of effectiveness under application
number 141-552.
See full Prescribing Information at
Canalevia.com.
Forward-Looking Statements
Certain statements in this press release constitute “forward-looking
statements.” These include statements regarding Jaguar’s expectation that it will host an investor webcast on August 14, 2023,
the Company’s expectation that top line results from the OnTarget study will be available in late October 2023, the Company’s
expectation that, with success, the indication of Mytesi will be expanded in 2024, the Company’s expectation that data from proof-of-concept
studies of crofelemer for MVID and SBS with intestinal failure will be available before the end of 2023 and in 2024, and Company’s
expectation that published data from such clinical investigations could support reimbursed early patient access to crofelemer for SBS
or MVID, potentially in 2024. In some cases, you can identify forward-looking statements by terms such as “may,” “will,”
“should,” “expect,” “plan,” “aim,” “anticipate,” “could,” “intend,”
“target,” “project,” “contemplate,” “believe,” “estimate,” “predict,”
“potential” or “continue” or the negative of these terms or other similar expressions. The forward-looking statements
in this release are only predictions. Jaguar has based these forward-looking statements largely on its current expectations and projections
about future events. These forward-looking statements speak only as of the date of this release and are subject to several risks, uncertainties,
and assumptions, some of which cannot be predicted or quantified and some of which are beyond Jaguar’s control. Except as required
by applicable law, Jaguar does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result
of any new information, future events, changed circumstances or otherwise.
Source: Jaguar Health, Inc.
Contact:
hello@jaguar.health
Jaguar-JAGX
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