georgie18
3 semanas hace
MTEM...58s clearing here...+70% so far...today...🥳
georgie18
Member Level
Re: georgie18 post# 4516
Thursday, December 05, 2024 9:52:17 AM
Post#
4517
of 4517
MTEM...46s clearing here...🥳
georgie18
Member Level
Re: None
Thursday, December 05, 2024 8:09:17 AM
Post#
386496
of 386530
MTEM...3748...getting some volume here...🥳
georgie18
Member Level
Re: None
Wednesday, December 04, 2024 7:24:11 PM
Post#
4513
of 4515
MTEM...40...🥳...On December 4, 2024, Molecular Templates, Inc. (the “Company”) reconvened its previously adjourned special meeting of stockholders (the “Special Meeting”). The reconvened Special Meeting was held virtually and commenced at 10:00 am EST. At the Special Meeting, 2,479,252 shares of the Company’s common stock, or 37.66% of the outstanding shares of common stock entitled to vote as of the record date of October 15, 2024, were present in person or represented by proxy. The Company has not received proxies that would constitute a quorum and has decided to cancel the Special Meeting and to withdraw from consideration by the Company’s stockholders the proposals set forth in the Proxy Statement. The reconvened Special Meeting was adjourned without any further business being conducted and no proposals were approved.
georgie18
3 semanas hace
MTEM...46s clearing here...🥳
georgie18
Member Level
Re: None
Thursday, December 05, 2024 8:09:17 AM
Post#
386496
of 386530
MTEM...3748...getting some volume here...🥳
georgie18
Member Level
Re: None
Wednesday, December 04, 2024 7:24:11 PM
Post#
4513
of 4515
MTEM...40...🥳...On December 4, 2024, Molecular Templates, Inc. (the “Company”) reconvened its previously adjourned special meeting of stockholders (the “Special Meeting”). The reconvened Special Meeting was held virtually and commenced at 10:00 am EST. At the Special Meeting, 2,479,252 shares of the Company’s common stock, or 37.66% of the outstanding shares of common stock entitled to vote as of the record date of October 15, 2024, were present in person or represented by proxy. The Company has not received proxies that would constitute a quorum and has decided to cancel the Special Meeting and to withdraw from consideration by the Company’s stockholders the proposals set forth in the Proxy Statement. The reconvened Special Meeting was adjourned without any further business being conducted and no proposals were approved.
subslover
2 meses hace
Read this horse-shit =In a turbulent market environment, Molecular Templates Inc. (NASDAQ:MTEM) stock has plummeted to a 52-week low, reaching a distressing price level of $0.31. This significant downturn reflects a staggering 1-year change with the company's stock value eroding by -94.83%. Investors have watched with concern as the biopharmaceutical company, known for its innovative therapeutic products, grapples with the pressures that have led to this concerning milestone. The sharp decline over the past year underscores the volatility and challenges faced by the biotech sector at large, as well as company-specific hurdles that have impacted investor confidence and stock performance.
"In other recent news, Molecular Templates, Inc. held its annual stockholder meeting, marking several significant developments. The meeting led to the election of Corsee Sanders, Ph.D., to the Board of Directors as a Class II director for a term of three years. The ratification of Ernst & Young LLP as the company's independent registered public accounting firm for the fiscal year ending December 31, 2024, was another major resolution passed. Additionally, the compensation of the company's named executive officers was approved on an advisory basis. These developments reflect the latest in the company's governance and financial oversight. It's important to note that these are recent developments and may shape the company's strategic direction. As always, investors are advised to consider analyst projections and assessments in their decision-making process."
InvestingPro Insightshttps://za.investing.com/news/company-news/mtem-stock-touches-52week-low-at-031-amid-market-challenges-93CH-3370204
INFINITI
2 años hace
Molecular Templates Announces IND Acceptance by FDA for MT-8421 ETB Program Targeting CTLA-4
Source: GlobeNewswire Inc.
Molecular Templates, Inc. (Nasdaq: MTEM, “Molecular Templates,” or “MTEM”), a clinical-stage biopharmaceutical company focused on the discovery and development of proprietary targeted biologic therapeutics, engineered toxin bodies (“ETBs”), to create novel therapies with potent differentiated mechanisms of action for cancer, has received clearance by the United States Food and Drug Administration (“FDA”) following review of its Investigational New Drug Application (“IND”) to proceed for clinical testing of its novel MT-8421 ETB program targeting CTLA-4 in patients with relapsed/refractory solid tumors previously exposed to checkpoint inhibitors.
“MT-8421 represents a novel approach to target CTLA-4 in a wholly distinct manner from the current monoclonal antibody approaches. MT-8421 was designed to eliminate CTLA-4-expressing Tregs in the tumor microenvironment (“TME”) through a direct cell-kill mechanism independent of the effector cell presence that antibodies rely upon while not effecting Tregs in the periphery, the major mechanism of antibody-mediated autoimmune toxicity,” said Eric Poma, Chief Executive Officer and Chief Scientific Officer of MTEM.
Preclinical data from MT-8421 showed that in a transgenic mouse model expressing human CTLA-4 and bearing syngeneic subcutaneous tumors, MT-8421 treatment depleted immune suppressive Tregs in the TME but not in the periphery. MT-8421 was well tolerated in a non-human GLP primate toxicology study and achieved serum levels well-above projected IC50 concentrations for Tregs in the TME. MTEM expects to initiate a first-in-human phase I study with MT-8421 by mid-year 2023 at a starting dose of 32 mcg/kg.
About Molecular Templates
Molecular Templates is a clinical-stage biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics. Our proprietary drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer.
Forward-Looking Statements
This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Molecular Templates disclaims any intent or obligation to update these forward-looking statements and claims the protection of the Act’s Safe Harbor for forward-looking statements. All statements, other than statements of historical facts, included in this press release regarding strategy, future operations, future financial position, future revenue, projected expenses, prospects, plans and objectives of management are forward-looking statements. In addition, when or if used in this press release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and similar expressions and their variants, as they relate to Molecular Templates may identify forward-looking statements. Examples of such statements include, but are not limited to, statements regarding the safety or potential efficacy of Molecular Templates’ drug or biologic candidates; the prospects of CTLA-4 targeting therapies as a potential treatment; statements relating to the development of MT-8421; the expected timing of initiating and completing enrollment of cohorts and conducting the planned Phase I study of MT-8421; and Molecular Templates’ belief that its proprietary biologic drug platform technology, or ETBs, provides for a differentiated mechanism of action for cancer.
Forward-looking statements are not guarantees of future performance and involve risks and uncertainties. Actual events or results may differ materially from those discussed in the forward-looking statements as a result of various factors including, but not limited to, the uncertainties inherent in the preclinical and clinical development process, including the fact that interim results may not be indicative of future results; whether Molecular Templates’ cash resources, will be sufficient to fund its continuing operations for the periods and/or trials anticipated; Molecular Templates’ ability to timely enroll patients in its clinical trials; the ability of Molecular Templates’ to protect its intellectual property rights; risks from global pandemics including COVID-19; and legislative, regulatory, political and economic developments, as well as those risks identified under the heading “Risk Factors” in Molecular Templates’ filings with the SEC. There can be no assurance that any of Molecular Templates’ drug or biologic candidates will be successfully developed, manufactured, or commercialized, that final results of clinical trials will be supportive of regulatory approvals required to market products, or that any of the forward-looking information provided herein will be proven accurate. Any forward-looking statements contained in this press release speak only as of the date hereof, and Molecular Templates specifically disclaims any obligation to update any forward-looking statement, whether because of new information, future events or otherwise.
Contacts:
Dr. Grace Kim
Head of Investor Relations
grace.kim@mtem.com
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subslover
2 años hace
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Molecular Templates Announces IND Acceptance by FDA for MT-8421 ETB Program Targeting CTLA-4
March 09 2023 - 10:02AM
GlobeNewswire Inc.
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Molecular Templates, Inc. (Nasdaq: MTEM, “Molecular Templates,” or “MTEM”), a clinical-stage biopharmaceutical company focused on the discovery and development of proprietary targeted biologic therapeutics, engineered toxin bodies (“ETBs”), to create novel therapies with potent differentiated mechanisms of action for cancer, has received clearance by the United States Food and Drug Administration (“FDA”) following review of its Investigational New Drug Application (“IND”) to proceed for clinical testing of its novel MT-8421 ETB program targeting CTLA-4 in patients with relapsed/refractory solid tumors previously exposed to checkpoint inhibitors.
“MT-8421 represents a novel approach to target CTLA-4 in a wholly distinct manner from the current monoclonal antibody approaches. MT-8421 was designed to eliminate CTLA-4-expressing Tregs in the tumor microenvironment (“TME”) through a direct cell-kill mechanism independent of the effector cell presence that antibodies rely upon while not effecting Tregs in the periphery, the major mechanism of antibody-mediated autoimmune toxicity,” said Eric Poma, Chief Executive Officer and Chief Scientific Officer of MTEM.
Preclinical data from MT-8421 showed that in a transgenic mouse model expressing human CTLA-4 and bearing syngeneic subcutaneous tumors, MT-8421 treatment depleted immune suppressive Tregs in the TME but not in the periphery. MT-8421 was well tolerated in a non-human GLP primate toxicology study and achieved serum levels well-above projected IC50 concentrations for Tregs in the TME. MTEM expects to initiate a first-in-human phase I study with MT-8421 by mid-year 2023 at a starting dose of 32 mcg/kg.
About Molecular Templates
Molecular Templates is a clinical-stage biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics. Our proprietary drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer.
Forward-Looking Statements
This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Molecular Templates disclaims any intent or obligation to update these forward-looking statements and claims the protection of the Act’s Safe Harbor for forward-looking statements. All statements, other than statements of historical facts, included in this press release regarding strategy, future operations, future financial position, future revenue, projected expenses, prospects, plans and objectives of management are forward-looking statements. In addition, when or if used in this press release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and similar expressions and their variants, as they relate to Molecular Templates may identify forward-looking statements. Examples of such statements include, but are not limited to, statements regarding the safety or potential efficacy of Molecular Templates’ drug or biologic candidates; the prospects of CTLA-4 targeting therapies as a potential treatment; statements relating to the development of MT-8421; the expected timing of initiating and completing enrollment of cohorts and conducting the planned Phase I study of MT-8421; and Molecular Templates’ belief that its proprietary biologic drug platform technology, or ETBs, provides for a differentiated mechanism of action for cancer.
Forward-looking statements are not guarantees of future performance and involve risks and uncertainties. Actual events or results may differ materially from those discussed in the forward-looking statements as a result of various factors including, but not limited to, the uncertainties inherent in the preclinical and clinical development process, including the fact that interim results may not be indicative of future results; whether Molecular Templates’ cash resources, will be sufficient to fund its continuing operations for the periods and/or trials anticipated; Molecular Templates’ ability to timely enroll patients in its clinical trials; the ability of Molecular Templates’ to protect its intellectual property rights; risks from global pandemics including COVID-19; and legislative, regulatory, political and economic developments, as well as those risks identified under the heading “Risk Factors” in Molecular Templates’ filings with the SEC. There can be no assurance that any of Molecular Templates’ drug or biologic candidates will be successfully developed, manufactured, or commercialized, that final results of clinical trials will be supportive of regulatory approvals required to market products, or that any of the forward-looking information provided herein will be proven accurate. Any forward-looking statements contained in this press release speak only as of the date hereof, and Molecular Templates specifically disclaims any obligation to update any forward-looking statement, whether because of new information, future events or otherwise.
Contacts:
Dr. Grace Kim
Head of Investor Relations
grace.kim@mtem.com
Primary Logo
Molecular Templates (NASDAQ:MTEM)
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Latest MTEM Messages
stockguard Thu Sep 26, 2019 3:30 PM (1260 days ago)
Molecular Templates: Pipeline Progressing, Clinical Updates Loom
stockguard Mon Sep 23, 2019 12:03 PM (1263 days ago)
Is Molecular Templates (NASDAQ:MTEM) Using Too Much Debt?
frankmertens Wed Nov 14, 2018 9:57 AM (1576 days ago)
What happened ?
PithicusKong Fri Oct 26, 2018 10:27 AM (1595 days ago)
The latest subscribers at $ 5.50 must not
PithicusKong Sun Sep 23, 2018 12:01 PM (1628 days ago)
A sizable chunk of dilution coming.
ClayTrader Wed Sep 19, 2018 6:50 PM (1632 days ago)
* * $MTEM Video Chart 09-19-18 * *
PithicusKong Wed Sep 19, 2018 9:01 AM (1632 days ago)
Major news...looks like money is going to flow
PithicusKong Sat Sep 8, 2018 9:12 AM (1643 days ago)
I guess not.....
PithicusKong Thu Aug 30, 2018 2:27 PM (1652 days ago)
Looks like this is trending up again.......
PithicusKong Wed Apr 4, 2018 9:58 PM (1800 days ago)
Any opinions on Annual report? Not one post
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Thu Mar 09, 2023 1:23 PM (17 hours ago)
Molecular Templates Announces IND Acceptance by FDA for MT-8421 ETB Program Targeting CTLA-4
GlobeNewswire Inc. • Thu Mar 09, 2023 10:02 AM (20 hours ago)
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GlobeNewswire Inc. • Wed Mar 01, 2023 4:44 PM (1 week ago)
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Molecular Templates, Inc. to Present Interim Results on MT-5111 at the 45th Annual San Antonio Breast Cancer Symposium (SABCS) and Participate at the 64th American Society of Hematology (ASH) Annual Meeting
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Current Report Filing (8-k)
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