As filed with the Securities and Exchange
Commission on August 2, 2024.
Registration No. 333-279036
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Amendment No. 1 to
FORM S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
INMUNE BIO INC.
(Exact name of registrant as specified in its charter)
Nevada |
|
47-5205835 |
(State or Other Jurisdiction of
Incorporation or Organization) |
|
(I.R.S. Employer
Identification Number) |
225 NE Mizner Blvd., Suite 640
Boca Raton, Florida 33432
(858) 964-3720
(Address, including zip code, and telephone number,
including area code of registrant’s principal executive offices)
David Moss
Chief Financial Officer
INmune Bio Inc.
225 NE Mizner Blvd., Suite 640
Boca Raton, Florida 33432
(858) 964-3720
(Name, address, including zip code, and telephone
number, including area code, of agent for service)
Copies to:
Marc Ross, Esq.
Thomas A. Rose, Esq.
David B. Manno, Esq.
Sichenzia Ross Ference Carmel LLP
1185 Avenue of the Americas, 31st
Floor
New York, New York 10036
(212) 930-9700
Approximate date of commencement of proposed sale to the public: From
time to time after the effective date of this registration statement.
If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following box: ☐
If any of the securities being registered on this Form are to be offered
on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection
with dividend or interest reinvestment plants, check the following box: ☒
If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following and list the Securities Act registration statement number
of the earlier effective registration statement for the same offering. ☐
If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration
statement for the same offering. ☐
If this Form is a registration statement pursuant to General Instruction
I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the
Securities Act, check the following box. ☐
If this Form is a post-effective amendment to a registration statement
filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule
413(b) under the Securities Act, check the following box. ☐
Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
“large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth
company” in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer |
☐ |
Accelerated filer |
☐ |
Non-accelerated filer |
☒ |
Smaller reporting company |
☒ |
Emerging growth company |
☒ |
|
|
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 7(a)(2)(B) of Securities Act. ☐
The registrant hereby amends this Registration Statement
on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically
states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933
or until the Registration Statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a),
may determine.
The information in this prospectus is
not complete and may be changed. We may not sell these securities until the registration statement relating to these securities that
has been filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and
it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.
(Subject to Completion,
dated August 2, 2024)
PROSPECTUS
$250,000,000
INMUNE BIO Inc.
Common Stock
Preferred Stock
Warrants
Units
We may from time to time, in one or more offerings
at prices and on terms that we will determine at the time of each offering, sell common stock, preferred stock, warrants, or a combination
of these securities, or units, up to a total offering price of $250,000,000.
This prospectus describes the general manner in
which our securities may be offered using this prospectus. Each time we offer and sell securities, we will provide you with a prospectus
supplement that will contain specific information about the terms of that offering. Any prospectus supplement may also add, update, or
change information contained in this prospectus. You should carefully read this prospectus and the applicable prospectus supplement as
well as the documents incorporated or deemed to be incorporated by reference in this prospectus before you purchase any of the securities
offered hereby.
We are an
“emerging growth company” under applicable Securities and Exchange Commission, rules and, as such, have elected to comply
with certain reduced public company reporting requirements for this prospectus and future filings.
This prospectus may not be used to offer and sell
securities unless accompanied by a prospectus supplement.
Our common stock is currently traded on The
Nasdaq Capital Market (“Nasdaq”) under the symbol “INMB.” On July 30, 2024, the last reported sales price for
our common stock was $8.26 per share. The applicable prospectus supplement will contain information, where applicable, as to any other
listing of the securities on Nasdaq or any other securities market or exchange covered by the prospectus supplement. Prospective purchasers
of our securities are urged to obtain current information as to the market prices of our securities, where applicable.
We may offer the securities directly or through
agents or to or through underwriters or dealers. If any agents or underwriters are involved in the sale of the securities their names,
and any applicable purchase price, fee, commission or discount arrangement between or among them, will be set forth, or will be calculable
from the information set forth, in an accompanying prospectus supplement. We can sell the securities through agents, underwriters or dealers
only with delivery of a prospectus supplement describing the method and terms of the offering of such securities. See “Plan of Distribution.”
The aggregate market value of our outstanding
common stock held by non-affiliates was approximately $132.2 million which was calculated based on 19,782,429 shares of outstanding common
stock held by non-affiliates as of July 30, 2024, and a price per share of $9.86, the closing price of our common stock on July 16, 2024.
Investing in our securities involves significant
risks. We strongly recommend that you read carefully the risks we describe in this prospectus and in any accompanying prospectus supplement,
as well as the risk factors that are incorporated by reference into this prospectus from our filings made with the Securities and Exchange
Commission. See “Risk Factors” beginning on page 5 of this prospectus.
Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete.
Any representation to the contrary is a criminal offense.
This prospectus is dated ___________, 2024
Table of Contents
You should rely only on the information contained
or incorporated by reference in this prospectus or any prospectus supplement. We have not authorized anyone to provide you with information
different from that contained or incorporated by reference into this prospectus. If any person does provide you with information that
differs from what is contained or incorporated by reference in this prospectus, you should not rely on it. No dealer, salesperson or other
person is authorized to give any information or to represent anything not contained in this prospectus. You should assume that the information
contained in this prospectus or any prospectus supplement is accurate only as of the date on the front of the document and that any information
contained in any document we have incorporated by reference is accurate only as of the date of the document incorporated by reference,
regardless of the time of delivery of this prospectus or any prospectus supplement or any sale of a security. These documents are not
an offer to sell or a solicitation of an offer to buy these securities in any circumstances under which the offer or solicitation is unlawful.
ABOUT THIS PROSPECTUS
This prospectus is part of a registration statement
that we filed with the Securities and Exchange Commission, or SEC, using a “shelf” registration process. Under this shelf
registration process, we may sell any combination of the securities described in this prospectus in one of more offerings up to a total
dollar amount of proceeds of $250,000,000. This prospectus describes the general manner in which our securities may be offered by this
prospectus. Each time we sell securities, we will provide a prospectus supplement that will contain specific information about the terms
of that offering. The prospectus supplement may also add, update or change information contained in this prospectus or in documents incorporated
by reference in this prospectus. The prospectus supplement that contains specific information about the terms of the securities being
offered may also include a discussion of certain U.S. Federal income tax consequences and any risk factors or other special considerations
applicable to those securities. To the extent that any statement that we make in a prospectus supplement is inconsistent with statements
made in this prospectus or in documents incorporated by reference in this prospectus, you should rely on the information in the prospectus
supplement. You should carefully read both this prospectus and any prospectus supplement together with the additional information described
under “Where You Can Find More Information” before buying any securities in this offering.
The terms “INmune Bio”, the “Company,”
“we,” “our,” or “us,” in this prospectus refer to INmune Bio Inc. and its wholly-owned subsidiaries,
unless the context suggests otherwise.
CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING
STATEMENTS
Some of the statements made under “Prospectus
Summary,” “Use of Proceeds,” and elsewhere in this prospectus, as well as the documents incorporated by reference herein,
including in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, constitute forward-looking statements within
the meaning of The Private Securities Litigation Reform Act of 1995. In some cases, you can identify forward-looking statements by terminology
such as “may,” “will,” “should,” “expects,” “plans,” “anticipates,”
“believes,” “estimates,” “predicts,” “potential,” “intends,” or “continue,”
or the negative of these terms or other comparable terminology.
These forward-looking statements may include, but
are not limited to, statements related to our expected business, new product introductions, results of clinical studies, expectations
regarding regulatory clearance and the timing of FDA or non-US filings or approvals including meetings with FDA or non-U.S. regulatory
bodies, our ability to raise funds for general corporate purposes and operations, including our research activities and clinical trials,
procedures and procedure adoption, future results of operations, future financial position, our ability to generate revenues, our financing
plans and future capital requirements, anticipated costs of revenue, anticipated expenses, the effect of recent accounting pronouncements,
our anticipated cash flows, our ability to finance operations from cash flows or otherwise, and statements based on current expectations,
estimates, forecasts, and projections about the economies and markets in which we operate and intend to operate and our beliefs and assumptions
regarding these economies and markets.
Forward-looking statements are not guarantees of
future performance and are subject to risks and uncertainties. We have based these forward-looking statements on assumptions and assessments
made by our management in light of their experience and their perception of historical trends, current conditions, expected future developments,
and other factors they believe to be appropriate.
Important factors that could cause actual results,
developments and business decisions to differ materially from those anticipated in these forward-looking statements include, among others,
those factors referred to in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, which is incorporated by reference
herein.
These statements are only current predictions and
are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry’s actual results, levels
of activity, performance, or achievements to be materially different from those anticipated by the forward-looking statements. We discuss
many of these risks in the documents incorporated by reference herein. You should not rely upon forward-looking statements as predictions
of future events.
Although we believe that the expectations reflected
in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance, or achievements.
Except as required by law, we are under no duty to update or revise any of the forward-looking statements, whether as a result of new
information, future events or otherwise, after the date of this prospectus.
PROSPECTUS SUMMARY
This summary highlights certain information
about us and selected information contained in the prospectus. This summary is not complete and does not contain all of the information
that may be important to you. For a more complete understanding of the Company, we encourage you to read and consider the more detailed
information included or incorporated by reference in this prospectus and our most recent consolidated financial statements and related
notes.
We are a clinical-stage immunology company focused
on developing drugs that may reprogram the patient’s innate immune system to treat disease. We believe this may be done by targeting
cells of the innate immune system that cause acute and chronic inflammation and are involved in immune dysfunction associated with chronic
diseases such as cancer and neurodegenerative diseases. The Company’s drugs are in clinical trials and have not been approved by
a regulatory authority. The Company has two therapeutic platforms – a dominant-negative TNF platform (“DN-TNF”, “XPro™”,
“XPro1595™” or “pegipanermin”) and a Natural Killer (“NK”, or “INKmune™”)
platform. The DN-TNF platform neutralizes soluble TNF (“sTNF”) without affecting trans-membrane TNF (“tmTNF”)
or TNF receptors -TNFR1 and TNFR2. This unique biologic mechanism differentiates the DN-TNF drugs from currently approved non-selective
TNF inhibitors that inhibit both sTNF and tmTNF. Protecting the function of tmTNF and TNF receptors while neutralizing the function of
sTNF is a potent anti-inflammatory strategy that does not cause immunosuppression or demyelination which occur in the currently approved
non-selective TNF inhibitors. Currently approved non-selective TNF inhibitors treat autoimmune disease, but are contraindicated in patients
with infection, cancer and neurologic diseases because they increase the risk of infection, cancer and demyelinating neurologic diseases,
respectively; these safety problems are due to off-target effects on inhibiting tmTNF. The NK platform targets the dysfunctional natural
killer cells in patients with cancer. NK cells are part of the normal immunologic response to cancer with important roles in immunosurveillance
to prevent cancer and in preventing relapse by eliminating residual disease. Residual disease is the cancer left behind after therapy
is finished. Residual disease can grow to cause relapse. The mechanism by which INKmune improves the ability of the patient’s NK
cells to kill their cancer is complex. The NK cells of cancer patients lose the ability to bind and kill cancer cells. A measure of NK
cell binding to cancer cells is avidity. The higher the avidity, the greater the bond between the NK cell to cancer cell and thus the
greater NK killing of cancer cells. INKmune increases NK avidity and further improves mitochondrial function and upregulates nutrient
receptors. These metabolic changes may help the INKmune primed NK cell to function in the hostile tumor microenvironment and persist much
longer. These mechanisms improve the ability of INKmune primed NK cells to overcome the immune evasion of the patient’s cancer cells.
We believe INKmune is best used to eliminate residual disease after the patient has completed other cancer therapies. Both the DN-TNF
platform and the INKmune platform can be used to treat multiple diseases. The DN-TNF platform will be used as an immunotherapy for the
treatment of cancer and neurodegenerative disease. INKmune is being developed to treat NK sensitive hematologic malignancies and solid
tumors.
We believe our DN-TNF platform
can be used as a CNS (“central nervous system”) therapy to target glial activation to prevent progression of Alzheimer’s
disease (“AD”); to target neuroinflammation in treatment resistant depression (“TRD”); as a drug to prevent muscle
degeneration, prevent fibrosis and promote muscle regeneration in Duchene muscular dystrophy (“DMD”); and as a cancer therapy
to reduce resistance in immunotherapy. The primary focus of the company’s development efforts for XPro is AD. The next indication
to be developed with XPro will be TRD. Treatment of DMD and cancer will occur when partners for the programs are found. The drug is named
differently for the oncology and CNS indications; INB03™ or XPro, respectively, but it is the same drug product. For DMD, the company
is exploring DN-TNF compounds that is optimized for the treatment of DMD. This novel compound has the same mechanism of action but has
novel IP protection. In each case, we believe neutralizing sTNF is a cornerstone to the treatment of these diseases. As an immunotherapy
for cancer, we are using INB03 to neutralize sTNF produced by HER2+ trastuzumab resistant breast cancers to reverse resistance to targeted
therapy. sTNF produced by the tumor causes an up-regulation of MUC4 express causing steric hindrance of trastuzumab binding to the HER
receptor on HER2+ breast cancer cells. Without binding, trastuzumab based therapies are not effective. Neutralizing sTNF reverses MUC4
expression converting a trastuzumab resistant breast cancer cell into a trastuzumab sensitive breast cancer cell. In addition, INB03 may
change the immunobiology of the tumor microenvironment by decreasing the number of immunosuppressive myeloid cells, both myeloid derived
suppressor cells and tumor active macrophages, and increasing the number of cytotoxic lymphocytes and phagocytic macrophages in the TME.
The Company has completed an open label dose escalation trial in cancer patients with metastatic solid tumors that have failed multiple
lines of therapy. The pre-clinical data in MUC4+ expressing tumors and the clinical trial informs the design of a future Phase II trial
by demonstrating that INB03 was safe and well tolerated, defined the dose of INB03 to carry into Phase II trials, and demonstrated a pharmacodynamic
end-point. The company does not plan to commence a Phase II trial in patients with advanced MUC4+ expressing cancer until a partner can
be found.
Likewise, we believe the DN-TNF
platform can be used to treat selected neurodegenerative diseases by modifying the brain microenvironment (“BME”). The Company
believes the core pathology of cognitive decline is a combination of neurodegeneration and synaptic dysfunction. Neurodegeneration is
nerve cell death that may include demyelination. Synaptic dysfunction means the connections between nerve cells stop working efficiently
and may decrease in number. The combination of neurodegeneration and synaptic dysfunction causes cognitive decline and behavioral changes
associated with Alzheimer’s disease (“AD”). XPro completed a Phase I trial treating patients with Alzheimer’s
disease that was partially funded by a Part-the-Clouds Award from the Alzheimer’s Association. We believe XPro targets activated
microglia and astrocytes of the brain that produce sTNF that promotes nerve cell loss, synaptic dysfunction and prevents myelin repair
- key elements in the development of dementia. In animal models, elimination of sTNF prevents nerve cell dysfunction, reverses synaptic
pruning and promotes myelin repair. The Phase I trial in patients with biomarkers of inflammation with AD has been completed. The open
label, dose escalation trial was designed to demonstrate that XPro can safely decrease neuroinflammation in patients with ADi. ADi is
the term used to delineate patients with AD with biomarkers of inflammation. The endpoints of the trial were measures of neuroinflammation
and neurodegeneration in blood and cerebral spinal fluid by measuring changes in inflammatory cytokine levels in the CNS and using MRI-DTI
to measure brain microstructural changes. XPro, at the 1mg/kg/week dose, decreased inflammatory cytokines in the CSF in the brain demonstrating
that XPro can decrease neuroinflammation in patients with AD. We also studied downstream benefits of decreasing neuroinflammation by measuring
changes in the CSF proteome and quantifying changes in novel white matter MRI biomarkers. XPro significantly decreases biomarkers of neurodegeneration as
measured by changes in the CSF proteome including neurofilament light chain, phospho Tau 217 and VILIP-1; decreases of 84%, 46% and 91%
respectively after 3 months of therapy. Three months of XPro therapy improved measures of synaptic function, as measured in the CSF proteome
including a 222% increase in Contactin 2 and a 56% decrease neurogranin, changes that contribute to improved synaptic function.
The successful completion
of the Phase I trial in AD has informed the design of a blinded randomized, placebo-controlled Phase II trial in patients with early ADi.
Early ADi includes patients with AD and MCI who have at least one biomarker of inflammation (ADi and MCI2 respectively).
The early ADi trial is a blinded randomized trial to test if treatment of early AD patients with neuroinflammation with XPro will affect
cognitive decline. The Phase II trial in early ADi has six important elements. Two hundred and one patients are being enrolled in a 2:1
ratio (XPro vs placebo). The patients will receive 1mg/kg/week as a subcutaneous injection for six months. An enrichment strategy identical
to the successful strategy used in the Phase I trial will be used to ensure patients have neuroinflammation. Patients will need to have
one or more enrichment criteria: elevated blood level of at least one of C-reactive protein, hemoglobin A1c, erythrocyte sedimentation
and at least one allele of ApoE4. The primary end-point will be Early/mild Alzheimer’s Cognitive Composite (“EMACC”),
a validated cognitive measure that is more sensitive than traditional end-points used in many studies of patients with early AD. The AD
program is open in the United States, Australia, Canada, the United Kingdom, France, Germany, Spain, Czech Republic and Slovakia. All
patients will be offered to stay on therapy for at least 12 months in an extension trial. Clinical and biomarker data will be collected
during the extension trial.
There are at least 4 clinical
milestones associated with the Phase II trial in AD. Enrollment of 201 patients in the Phase II AD trial should be complete by mid-year.
Six months after the last patient is enrolled, top line cognition data with EMACC will be available. Secondary end-points which include
blood biomarker, neuroimaging and additional neuropsychiatric end-points will be available after data base lock 2-3 months after top line
data. Finally, several months after all the data are analyzed, the Company plans an end-of-phase II meeting with the FDA to finalize plans
for the pivotal Phase III trial. The Company plans to apply for an accelerated pathway during 2024. XPro for treatment of AD may be eligible
for one or both accelerated approval pathways. The Company plans to submit of Fast Track status in 2024. We expect to be eligible for
Break Through status after completion of the Phase II in 2025.
Effective therapy for TRD
is a large unmet need. Twenty percent of patients with a Major Depressive Disorder have TRD. Once third of TRD patients have peripheral
biomarkers to inflammation (elevated CRP). This is a large patient population. The role of TNF and anti-TNF therapeutics was explored
in a small open label clinical trial by Prof. Andrew Miller, MD of Emory University demonstrated the patients have elevated TNF levels
and treatment with infliximab treated their depression (Miller, 2011). The Company received a $2.9M USD award from the National Institute
of Mental Health (“NIMH”) to treat TRD with XPro. The blinded, randomized Phase II trial will use biomarkers of peripheral
inflammation to select patients with TRD for enrollment. Patients will be treated for 6 weeks. Primary end-points include both clinical
and neuroimaging measures. The final trial design is ongoing and discussions with the FDA are not complete. The Company received authorization
to initiate a clinical trial in AD in the US during January 2024. The TRD trial is expected to start enrollment after the AD Phase II
trial finishes patient enrollment.
We believe that INKmune improves
the ability of the patient’s own NK cells to attack their tumor. INKmune interacts with the patient’s NK cells to convert
them from inert resting NK cells into memory-like NK cells that kill the patient’s cancer cells. INKmune is a replication incompetent
proprietary cell line that is given to the patient after determining that i) the patient has adequate NK cells in their circulation and
ii) those NK cells are functional when exposed to INKmune in vitro. INKmune is designed to be given to patients after their immune system
has recovered after cytotoxic chemotherapy to target the residual disease that remains after treatment with cytotoxic therapy. We believe
INKmune can be used to treat numerous hematologic malignancies and solid tumors including leukemia, multiple myeloma, lymphoma, lung,
ovary, breast, renal and prostate cancer. The Company had a Phase I trial using INKmune to treat patients with high risk MDS/AML, a form
of leukemia. Two patients were treated in the Phase I trial for MDS, three patients have been treated compassionately in AML and another
MDS patient is expected to be treated shortly. During March 2024, the Company decided to terminate further enrollment in the MDS/AML trial.
In the patients, INKmune therapy is safe, produces memory-like NK cells that kill cancer in vitro, and promotes development of cancer
killing memory-like NK cells that can be found in the patient’s circulation of 4 months. The Company initiated a separate Phase
I/2 trial of INKmune in a metastatic castrate resistant prostate cancer. The open label trial enrolled the first patient in December 2023.
The Phase I/II trial using
INKmune to treat patients with metastatic castrate resistant prostate cancer (mCPRC) is an open label trial. Biomarker data from the patients
will be visible as patients are treated. The Company will report data from each cohort as it becomes available. In addition to clinical
data, the Company will communicate when the Phase I portion of the trial has completely enrolled. This is expected in September 2024.
Because of the modified Bayesian design, the Company estimates the trial will be completely enrolled 1H25 with top-line data available
6 months later. Topline data is divided into immunologic and tumor response variables. The most important immunologic response variable
is related to memory like NK cell persistence. This is how long are the number of mlNK cells in patients blood compared to baseline. There
are 3 important variables to tumor response: i) blood PSA changes; ii) change in PMSA scan and iii) change in circulating tumor DNA (ctDNA).
Ideally, the levels of all three variables decrease with treatment. We do not expect this 6 month trial to provide survival data.
We continue to incur significant
development and other expenses related to our ongoing operations. As a result, we are not and have never been profitable and have incurred
losses in each period since our inception, resulting in substantial doubt in our ability to continue as a going concern. We reported a
net loss of $30.0 million and $27.3 million for the years ended December 31, 2023 and 2022, respectively. As of December 31, 2023 and
2022, we had cash and cash equivalents of $35.8 million and $52.2 million, respectively. We expect to continue to incur significant losses
for the foreseeable future, and we expect these losses to increase as we continue our research and development of, and seek regulatory
approvals for, our product candidates. The size of our future net losses will depend, in part, on the rate of future growth of our expenses
and our ability to generate revenues, if any.
Our recurring net losses and
negative cash flows from operations raised substantial doubt regarding our ability to continue as a going concern within one year after
the issuance of our consolidated financial statements for the year ended December 31, 2023. Until we can generate sufficient revenue from
the commercialization of our product candidates, we expect to finance our operations through the public or private sale of equity, debt
financings or other capital sources, such as government funding, collaborations, strategic alliances, divestment of non-core assets, or
licensing arrangements with third parties. To date, the Company has relied on equity and debt financing to fund its operations.
Implications of Being an Emerging Growth Company and a Smaller Reporting Company
We qualify as an “emerging growth company”
as defined in Section 2(a)(19) of the Securities Act of 1933, as modified by the Jumpstart Our Business Startups Act of 2012, or
the “JOBS Act.” As such, we take advantage of certain exemptions from various reporting requirements applicable to other public
companies that are not emerging growth companies for as long as we continue to be an emerging growth company, including (i) the exemption
from the auditor attestation requirements with respect to internal control over financial reporting under Section 404 of the Sarbanes-Oxley
Act of 2002 (the “Sarbanes-Oxley Act”), (ii) the exemptions from say-on-pay, say-on-frequency and say-on-golden parachute
voting requirements and (iii) reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements.
As a result, our stockholders may not have access to certain information they deem important. We will remain an emerging growth company
until the earliest of (i) the last day of the fiscal year (a) December 31, 2024, which is the last day of the fiscal year following the
fifth anniversary of the date of the first sale of the Company’s common stock, (b) in which we have total annual gross revenue of
at least $1.235 billion or (c) in which INmune Bio is deemed to be a large accelerated filer, which means the market value of our common
stock that are held by non-affiliates exceeds $700 million as of the last business day of our prior second fiscal quarter, and (ii) the
date on which we have issued more than $1.0 billion in non-convertible debt during the prior three-year period.
In addition, Section 107 of the JOBS Act also
provides that an emerging growth company can take advantage of the exemption from complying with new or revised accounting standards provided
in Section 7(a)(2)(B) of the Securities Act of 1933, as long as it is an emerging growth company. An emerging growth company
can therefore delay the adoption of certain accounting standards until those standards would otherwise apply to private companies. The JOBS
Act provides that a company can elect to opt out of the extended transition period and comply with the requirements that apply to
non-emerging growth companies, but any such election to opt out is irrevocable. The Company has elected not to opt out of such extended
transition period, which means that when a standard is issued or revised and it has different application dates for public or private
companies, we, as an emerging growth company, can adopt the new or revised standard at the time private companies adopt the new or revised
standard. This may make comparison of our financial statements with another public company which is neither an emerging growth company
nor an emerging growth company which has opted out of using the extended transition period difficult or impossible because of the potential
differences in accounting standards used.
Corporate Information
Our principal executive offices are located at
225 NE Mizner Blvd, Suite 640, Boca Raton, FL 33432. Our telephone number is (858) 964-3720. We maintain an Internet website at www.inmunebio.com.
The information contained on, connected to or that can be accessed via our website is not part of this prospectus. We have included our
website address in this prospectus as an inactive textual reference only and not as an active hyperlink.
RISK FACTORS
Investing in our securities involves a high degree
of risk. Before making an investment decision, you should consider carefully the risks, uncertainties and other factors described in our
most recent Annual Report on Form 10-K, as supplemented and updated by subsequent quarterly reports on Form 10-Q and current reports on
Form 8-K that we have filed or will file with the SEC, which are incorporated by reference into this prospectus.
Our business, affairs, prospects,
assets, financial condition, results of operations and cash flows could be materially and adversely affected by these risks. For more
information about our SEC filings, please see “Where You Can Find More Information”.
USE OF PROCEEDS
Unless otherwise indicated in a prospectus supplement,
we intend to use the net proceeds from the sale of the securities under this prospectus for general corporate purposes, including to support
research and development, including clinical trials, and general corporate purposes.
DESCRIPTION OF CAPITAL STOCK
General
The following description of our capital stock,
together with any additional information we include in any applicable prospectus supplement or any related free writing prospectus, summarizes
the material terms and provisions of our common stock and the preferred stock that we may offer under this prospectus. While the terms
we have summarized below will apply generally to any future common stock or preferred stock that we may offer, we will describe the particular
terms of any class or series of these securities in more detail in the applicable prospectus supplement. For the complete terms of our
common stock and preferred stock, please refer to our articles of incorporation and our bylaws that are incorporated by reference into
the registration statement of which this prospectus is a part. The summary below and that contained in any applicable prospectus supplement
or any related free writing prospectus are qualified in their entirety by reference to our articles of incorporation and our bylaws.
Common Stock
We are authorized to issue 200,000,000 shares
of common stock, $0.001 par value per share. As of the date of this prospectus, there are 19,760,985 shares of common stock issued
and outstanding. The outstanding shares of common stock are validly issued, fully paid and nonassessable.
Holders of common stock are
entitled to one vote for each share on all matters presented to the stockholders. Holders of common stock do not have cumulative voting
rights. Therefore, holders of a plurality of the shares of common stock voting for the election of directors can elect all of the directors.
Holders of common stock representing 33.3 percent of our capital stock issued, outstanding and entitled to vote, represented in person
or by proxy, are necessary to constitute a quorum at any meeting of stockholders.
Holders of common stock are
entitled to share in all dividends that our Board of Directors, in its discretion, declares from legally available funds. In the event
of a liquidation, dissolution or winding up, each outstanding share entitles its holder to participate pro rata in all assets that remain
after payment of liabilities and after providing for each class of stock, if any, having preference over the common stock. The common
stock has no pre-emptive, subscription or conversion rights and there are no redemption provisions applicable to the common stock.
Preferred Stock
We are authorized to issue up to 10,000,000 shares
of preferred stock, par value $0.001 per share, from time to time in one or more series. On December 30, 2020, we filed a Certificate
of Designation of Series A Junior Preferred Stock with the Secretary of State of the State of Delaware to designate 45,000 shares as Series
A Preferred Junior Participating Preferred Stock. As of the date of this prospectus, there were no shares of our preferred stock outstanding.
Our articles of incorporation authorizes our Board
of Directors to issue preferred stock from time to time with such designations, preferences, conversion or other rights, voting powers,
restrictions, dividends or limitations as to dividends or other distributions, qualifications or terms or conditions of redemption as
shall be determined by the Board of Directors for each class or series of stock. Preferred stock is available for possible future financings
or acquisitions and for general corporate purposes without further authorization of stockholders unless such authorization is required
by applicable law, the rules of Nasdaq or other securities exchange or market on which our stock is then listed or admitted to trading.
Our Board of Directors may authorize the issuance
of preferred stock with voting or conversion rights that could adversely affect the voting power or other rights of the holders of common
stock. The issuance of preferred stock, while providing flexibility in connection with possible acquisitions and other corporate purposes
could, under some circumstances, have the effect of delaying, deferring or preventing a change-in-control of the Company.
A prospectus supplement relating to any series
of preferred stock being offered will include specific terms relating to the offering. Such prospectus supplement will include:
| ● | the
title and stated or par value of the preferred stock; |
| ● | the
number of shares of the preferred stock offered, the liquidation preference per share and the offering price of the preferred stock; |
| ● | the
dividend rate(s), period(s) and/or payment date(s) or method(s) of calculation thereof applicable to the preferred stock; |
| ● | whether
dividends shall be cumulative or non-cumulative and, if cumulative, the date from which dividends on the preferred stock shall accumulate; |
| ● | the
provisions for a sinking fund, if any, for the preferred stock; |
| ● | any
voting rights of the preferred stock; |
| ● | the
provisions for redemption, if applicable, of the preferred stock; |
| ● | any
listing of the preferred stock on any securities exchange; |
| ● | the
terms and conditions, if applicable, upon which the preferred stock will be convertible into our common stock, including the conversion
price or the manner of calculating the conversion price and conversion period; |
| ● | if
appropriate, a discussion of Federal income tax consequences applicable to the preferred stock; and |
| ● | any
other specific terms, preferences, rights, limitations or restrictions of the preferred stock. |
The terms, if any, on which the preferred stock
may be convertible into or exchangeable for our common stock will also be stated in the preferred stock prospectus supplement. The terms
will include provisions as to whether conversion or exchange is mandatory, at the option of the holder or at our option, and may include
provisions pursuant to which the number of shares of our common stock to be received by the holders of preferred stock would be subject
to adjustment.
Transfer Agent and Registrar
The transfer agent for our common stock is VStock
Transfer, LLC. The transfer agent’s address is 18 Lafayette Place, Woodmere, New York 11598.
Listing
Our common stock is currently traded on The Nasdaq
Capital Market under the symbol “INMB”.
DESCRIPTION OF WARRANTS
We may issue warrants for the purchase of preferred
stock or common stock. Warrants may be issued independently or together with any preferred stock or common stock, and may be attached
to or separate from any offered securities. Each series of warrants will be issued under a separate warrant agreement to be entered into
between a warrant agent specified in the agreement and us. The warrant agent will act solely as our agent in connection with the warrants
of that series and will not assume any obligation or relationship of agency or trust for or with any holders or beneficial owners of warrants.
This summary of some provisions of the securities warrants is not complete. You should refer to the securities warrant agreement, including
the forms of securities warrant certificate representing the securities warrants, relating to the specific securities warrants being offered
for the complete terms of the securities warrant agreement and the securities warrants. The securities warrant agreement, together with
the terms of the securities warrant certificate and securities warrants, will be filed with the SEC in connection with the offering of
the specific warrants.
The applicable prospectus supplement will describe
the following terms, where applicable, of the warrants in respect of which this prospectus is being delivered:
| ● | the
title of the warrants; |
| ● | the
aggregate number of the warrants; |
| ● | the
price or prices at which the warrants will be issued; |
| ● | the
designation, amount and terms of the offered securities purchasable upon exercise of the warrants; |
| ● | if
applicable, the date on and after which the warrants and the offered securities purchasable upon exercise of the warrants will be separately
transferable; |
| ● | the
terms of the securities purchasable upon exercise of such warrants and the procedures and conditions relating to the exercise of such
warrants; |
| ● | any
provisions for adjustment of the number or amount of securities receivable upon exercise of the warrants or the exercise price of the
warrants; |
| ● | the
price or prices at which and currency or currencies in which the offered securities purchasable upon exercise of the warrants may be
purchased; |
| ● | the
date on which the right to exercise the warrants shall commence and the date on which the right shall expire; |
| ● | the
minimum or maximum amount of the warrants that may be exercised at any one time; |
| ● | information
with respect to book-entry procedures, if any; |
| ● | if
appropriate, a discussion of Federal income tax consequences; and |
| ● | any
other material terms of the warrants, including terms, procedures and limitations relating to the exchange and exercise of the warrants. |
Warrants for the purchase of common stock or preferred
stock will be offered and exercisable for U.S. dollars only. Warrants will be issued in registered form only.
Upon receipt of payment and the warrant certificate
properly completed and duly executed at the corporate trust office of the warrant agent or any other office indicated in the applicable
prospectus supplement, we will, as soon as practicable, forward the purchased securities. If less than all of the warrants represented
by the warrant certificate are exercised, a new warrant certificate will be issued for the remaining warrants.
Prior to the exercise of any securities warrants
to purchase preferred stock or common stock, holders of the warrants will not have any of the rights of holders of the common stock or
preferred stock purchasable upon exercise, including in the case of securities warrants for the purchase of common stock or preferred
stock, the right to vote or to receive any payments of dividends on the preferred stock or common stock purchasable upon exercise.
DESCRIPTION OF UNITS
As specified in the applicable prospectus supplement,
we may issue units consisting of shares of common stock, shares of preferred stock or warrants or any combination of such securities.
The applicable prospectus supplement will specify
the following terms of any units in respect of which this prospectus is being delivered:
|
● |
the terms of the units and of any of the common stock, preferred stock and warrants comprising the units, including whether and under what circumstances the securities comprising the units may be traded separately; |
|
● |
a description of the terms of any unit agreement governing the units; and |
|
● |
a description of the provisions for the payment, settlement, transfer or exchange of the units. |
PLAN OF DISTRIBUTION
We may sell the securities offered through this
prospectus (i) to or through underwriters or dealers, (ii) directly to purchasers, including our affiliates, (iii) through
agents, or (iv) through a combination of any these methods. The securities may be distributed at a fixed price or prices, which may be
changed, market prices prevailing at the time of sale, prices related to the prevailing market prices, or negotiated prices. The prospectus
supplement will include the following information:
| ● | the
terms of the offering; |
| ● | the
names of any underwriters or agents; |
| ● | the
name or names of any managing underwriter or underwriters; |
| ● | the
purchase price of the securities; |
| ● | any
over-allotment options under which underwriters may purchase additional securities from us; |
| ● | the
net proceeds from the sale of the securities |
| ● | any
delayed delivery arrangements |
| ● | any
underwriting discounts, commissions and other items constituting underwriters’ compensation; |
| ● | any
initial public offering price; |
| ● | any
discounts or concessions allowed or reallowed or paid to dealers; |
| ● | any
commissions paid to agents; and |
| ● | any
securities exchange or market on which the securities may be listed. |
Sale Through Underwriters or Dealers
Only underwriters named in the prospectus supplement
are underwriters of the securities offered by the prospectus supplement.
If underwriters are used in the sale, the underwriters
will acquire the securities for their own account, including through underwriting, purchase, security lending or repurchase agreements
with us. The underwriters may resell the securities from time to time in one or more transactions, including negotiated transactions.
Underwriters may sell the securities in order to facilitate transactions in any of our other securities (described in this prospectus
or otherwise), including other public or private transactions and short sales. Underwriters may offer securities to the public either
through underwriting syndicates represented by one or more managing underwriters or directly by one or more firms acting as underwriters.
Unless otherwise indicated in the prospectus supplement, the obligations of the underwriters to purchase the securities will be subject
to certain conditions, and the underwriters will be obligated to purchase all the offered securities if they purchase any of them. The
underwriters may change from time to time any initial public offering price and any discounts or concessions allowed or reallowed or paid
to dealers.
If dealers are used in the sale of securities offered
through this prospectus, we will sell the securities to them as principals. They may then resell those securities to the public at varying
prices determined by the dealers at the time of resale. The prospectus supplement will include the names of the dealers and the terms
of the transaction.
Direct Sales and Sales Through Agents
We may sell the securities offered through this
prospectus directly. In this case, no underwriters or agents would be involved. Such securities may also be sold through agents designated
from time to time. The prospectus supplement will name any agent involved in the offer or sale of the offered securities and will describe
any commissions payable to the agent. Unless otherwise indicated in the prospectus supplement, any agent will agree to use its reasonable
best efforts to solicit purchases for the period of its appointment.
We may sell the securities directly to institutional
investors or others who may be deemed to be underwriters within the meaning of the Securities Act of 1933 with respect to any sale of
those securities. The terms of any such sales will be described in the prospectus supplement.
Delayed Delivery Contracts
If the prospectus supplement indicates, we may
authorize agents, underwriters or dealers to solicit offers from certain types of institutions to purchase securities at the public offering
price under delayed delivery contracts. These contracts would provide for payment and delivery on a specified date in the future. The
contracts would be subject only to those conditions described in the prospectus supplement. The applicable prospectus supplement will
describe the commission payable for solicitation of those contracts.
Continuous Offering Program
Without limiting the generality of the foregoing,
we may enter into a continuous offering program equity distribution agreement with a broker-dealer, under which we may offer and sell
shares of our common stock from time to time through a broker-dealer as our sales agent. If we enter into such a program, sales of the
shares of common stock, if any, will be made by means of ordinary brokers’ transactions on Nasdaq at market prices, block transactions
and such other transactions as agreed upon by us and the broker-dealer. Under the terms of such a program, we also may sell shares of
common stock to the broker-dealer, as principal for its own account at a price agreed upon at the time of sale. If we sell shares of common
stock to such broker-dealer as principal, we will enter into a separate terms agreement with such broker-dealer, and we will describe
this agreement in a separate prospectus supplement or pricing supplement.
Market Making, Stabilization and Other Transactions
Unless the applicable prospectus supplement states
otherwise, other than our common stock all securities we offer under this prospectus will be a new issue and will have no established
trading market. We may elect to list offered securities on an exchange or in the over-the-counter market. Any underwriters that we use
in the sale of offered securities may make a market in such securities, but may discontinue such market making at any time without notice.
Therefore, we cannot assure you that the securities will have a liquid trading market.
Any underwriter may also engage in stabilizing
transactions, syndicate covering transactions and penalty bids in accordance with Rule 104 under the Securities Exchange Act of 1934
(the “Exchange Act”). Stabilizing transactions involve bids to purchase the underlying security in the open market for the
purpose of pegging, fixing or maintaining the price of the securities. Syndicate covering transactions involve purchases of the securities
in the open market after the distribution has been completed in order to cover syndicate short positions.
Penalty bids permit the underwriters to reclaim
a selling concession from a syndicate member when the securities originally sold by the syndicate member are purchased in a syndicate
covering transaction to cover syndicate short positions. Stabilizing transactions, syndicate covering transactions and penalty bids may
cause the price of the securities to be higher than it would be in the absence of the transactions. The underwriters may, if they commence
these transactions, discontinue them at any time.
General Information
Agents, underwriters, and dealers may be entitled,
under agreements entered into with us, to indemnification by us against certain liabilities, including liabilities under the Securities
Act of 1933. Our agents, underwriters, and dealers, or their affiliates, may be customers of, engage in transactions with or perform services
for us, in the ordinary course of business.
LEGAL MATTERS
The validity of the issuance
of the securities offered by this prospectus will be passed upon for us by Sichenzia Ross Ference Carmel LLP, New York, New York.
EXPERTS
The consolidated financial
statements of INmune Bio Inc. as of and for the years ended December 31, 2023 and 2022 appearing in INmune Bio Inc.’s Annual Report
on Form 10-K for the year ended December 31, 2023 have been audited by Marcum LLP, as set forth in its report thereon, which includes
an explanatory paragraph as to the Company’s ability to continue as a going concern, included therein, and incorporated herein by
reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such report given on the authority
of such firm as experts in accounting and auditing.
WHERE YOU CAN FIND MORE INFORMATION
We have filed our registration statement on
Form S-3 with the SEC under the Securities Act of 1933, as amended. We also file annual, quarterly and current reports, proxy statements
and other information with the SEC. You may read and copy any document that we file with the SEC, including the registration statement
and the exhibits to the registration statement, at the SEC’s Public Reference Room located at 100 F Street, N.E., Washington D.C.
20549. You may obtain further information on the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. Our SEC
filings are also available to the public at the SEC’s web site at www.sec.gov. These documents may also be accessed on our web
site at www.inmunebio.com. Information contained on our web site is not incorporated by reference into this prospectus and you should
not consider information contained on our web site to be part of this prospectus.
This prospectus and any prospectus
supplement are part of a registration statement filed with the SEC and do not contain all of the information in the registration statement.
The full registration statement may be obtained from the SEC or us as indicated above. Other documents establishing the terms of the offered
securities are filed as exhibits to the registration statement or will be filed through an amendment to our registration statement on
Form S-3 or under cover of a Current Report on Form 8-K and incorporated into this prospectus by reference.
INCORPORATION OF CERTAIN
DOCUMENTS BY REFERENCE
The
SEC allows us to “incorporate by reference” into this prospectus the information we file with it, which means that we can
disclose important information to you by referring you to those documents. The information incorporated by reference is considered to
be part of this prospectus. Any statement contained herein or in a document incorporated or deemed to be incorporated by reference into
this document will be deemed to be modified or superseded for purposes of the document to the extent that a statement contained in this
document or any other subsequently filed document that is deemed to be incorporated by reference into this document modifies or supersedes
the statement. We incorporate by reference in this prospectus the following information (other than, in each case, documents or information
deemed to have been furnished and not filed in accordance with SEC rules):
|
● |
our Annual Report on Form
10-K for the year ended December 31, 2023 filed with the SEC on March 28, 2024, and as amended by Form
10-K/A on April 16, 2024; |
|
● |
our
Current Reports on Form 8-K filed with the SEC on January
2, 2024, March
27, 2024, March 29, 2024, April
9, 2024, April
22, 2024, April
25, 2024, April
26, 2024, April 30,
2024, May 13, 2024, May 16,
2024, May 23, 2024, May
30, 2024, June 13, 2024, July
1, 2024, July 5, 2024, July
19, 2024 and July 30,
2024; |
|
● |
our Quarterly Reports on
Form 10-Q for the quarters ended March
31, 2024 and June 30, 2024, filed with the SEC on May 9, 2024 and August 1, 2024, respectively; |
|
● |
the description of our common stock contained in our
Registration Statement on Form 8-A
filed with the SEC on February 1, 2019 (File No. 001-38793), as amended by Exhibit
4.1 to our Annual Report on Form
10-K filed on March 3, 2022, including any subsequent amendment or any report filed for the purpose of updating such description;
and |
|
● |
all reports and other documents subsequently filed
by us pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date of this prospectus and prior to the termination
of this offering. |
We
also incorporate by reference any future filings (other than information furnished under Item 2.02 or Item 7.01 of Form 8-K
and exhibits furnished on such form that are related to such items unless such Form 8-K expressly provides to the contrary) made
with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, including those made after the date of the
initial filing of the registration statement of which this prospectus is a part and prior to effectiveness of such registration statement,
until we file a post-effective amendment that indicates the termination of the offering of the common stock made by this prospectus and
will become a part of this prospectus from the date that such documents are filed with the SEC. Information in such future filings updates
and supplements the information provided in this prospectus. Any statements in any such future filings will automatically be deemed to
modify and supersede any information in any document we previously filed with the SEC that is incorporated or deemed to be incorporated
herein by reference to the extent that statements in the later filed document modify or replace such earlier statements.
Notwithstanding
the foregoing, information furnished under Items 2.02 and 7.01 of any Current Report on Form 8-K, including the related exhibits, is
not incorporated by reference in this prospectus.
The
information about us contained in this prospectus should be read together with the information in the documents incorporated by reference.
You may request a copy of any or all of these filings, at no cost, by writing or telephoning us at: David Moss, INmune Bio Inc., 225
NE Mizner Blvd, Suite 640, Boca Raton, FL 33432, telephone number (858) 964-3720.
$250,000,000
Common Stock
Preferred Stock
Warrants
Units
INMUNE BIO INC.
Prospectus
, 2024
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 14. Other Expenses of Issuance and Distribution.
The following table sets forth the costs and expenses
payable by the Registrant in connection with this offering, other than underwriting commissions and discounts, all of which are estimated
except for the SEC registration fee.
Item |
|
Amount
|
|
SEC registration fee |
|
$ |
8,290.61 |
(1) |
FINRA filing fee |
|
$ |
38,000 |
|
Printing and engraving expenses |
|
$ |
* |
|
Legal fees and expenses |
|
$ |
* |
|
Accounting fees and expenses |
|
$ |
* |
|
Transfer agent and registrar’s fees and expenses |
|
$ |
* |
|
Miscellaneous expenses |
|
$ |
* |
|
Total |
|
$ |
* |
|
(1) |
In accordance with Rule 415(a)(6) under the Securities Act, the filing fee previously paid in connection with the securities registered in the registration statement on Form S-3 (File No. 333-254221) which remain unsold will continue to be applied to the securities registered under this Registration Statement. Please see the registration fee table contained in Exhibit 107 to this registration statement for more information. |
* |
These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be estimated at this time. In accordance with Rule 430B, the applicable prospectus supplement will set forth the estimated amount of expenses of any offering of securities. |
Item 15. Indemnification of Directors and Officers.
NRS 78.7502(1) provides that a corporation may
indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or
proceeding, whether civil, criminal, administrative or investigative, except an action by or in the right of the corporation, by reason
of the fact that he is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation
as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses,
including attorneys’ fees, judgments, fines and amounts paid in settlement actually and reasonably incurred by him in connection
with the action, suit or proceeding if he: (a) is not liable pursuant to NRS 78.138; or (b) acted in good faith and in a manner which
he reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding,
had no reasonable cause to believe his conduct was unlawful.
NRS Section 78.7502(2) provides that a corporation
may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit
by or in the right of the corporation to procure a judgment in its favor by reason of the fact that he is or was a director, officer,
employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent
of another corporation, partnership, joint venture, trust or other enterprise against expenses, including amounts paid in settlement and
attorneys’ fees actually and reasonably incurred by him in connection with the defense or settlement of the action or suit if he:
(a) is not liable pursuant to NRS 78.138; or (b) acted in good faith and in a manner which he reasonably believed to be in or not opposed
to the best interests of the corporation. Indemnification may not be made for any claim, issue or matter as to which such a person has
been adjudged by a court of competent jurisdiction, after exhaustion of all appeals there from, to be liable to the corporation or for
amounts paid in settlement to the corporation, unless and only to the extent that the court in which the action or suit was brought or
other court of competent jurisdiction determines upon application that in view of all the circumstances of the case, the person is fairly
and reasonably entitled to indemnity for such expenses as the court deems proper.
Our Articles of Incorporation provides that very
person who was or is a party to, or is threatened to be made a party to, or is involved in any action, suit or proceeding, whether civil,
criminal, administrative or investigative, by reason of the fact that he, or a person of whom he is the legal representative, is or was
a director or officer of the Company, or is or was serving at the request of the Company as a director or officer of another corporation,
or as its representative in a partnership, joint venture, trust or other enterprise, shall be indemnified and held harmless to the fullest
extent legally permissible under the laws of the State of Nevada from time to time against all expenses, liability and loss (including
attorney’s fees, judgements, fines and amounts paid or to be paid in settlement) reasonably incurred or suffered by him in connection
therewith. Such right of indemnification shall be a contract right which may be enforced in any matter desired by such person. The expenses
of the officers and directors incurred in defending a civil or criminal action, suit or proceeding must be paid by the Company as they
are incurred and in advance of the final disposition of the action, suit or proceeding, upon receipt of an undertaking by or on behalf
of the director or officer to repay the amount if it is ultimately determined by a court of competent jurisdiction that he is not entitled
to be indemnified by the Company. Such right of indemnification shall not be exclusive of any other right which such directors, officers
or representatives may have or hereafter acquire, and, without limiting the generality of such statement, they shall be entitled to their
respective rights of indemnification under any bylaw, agreement, vote of stockholders, provision of law, or otherwise, as well as their
rights under this Article.
NRS Section 78.747 provides
that except as otherwise provided by specific statute, no director or officer of a corporation is individually liable for a debt or liability
of the corporation, unless the director or officer acts as the alter ego of the corporation. The court as a matter of law must determine
the question of whether a director or officer acts as the alter ego of a corporation.
Insofar as indemnification for liabilities arising
under the Securities Act of 1933 may be permitted to directors, offices or controlling persons of ours, pursuant to the foregoing provisions,
or otherwise, we have been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the
Securities Act of 1933, and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other
than the payment by us of expenses incurred or paid by a director, officer or controlling person of ours in the successful defense of
any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered
hereunder, we will, unless in the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by us is against public policy as expressed in the Securities Act of 1933 and will
be governed by the final adjudication of such issue.
Item 16. Exhibits.
* |
To be filed by amendment or by a Current Report on Form 8-K and incorporated by reference herein. |
Item 17. Undertakings
(a) The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers
or sales are being made, a post-effective amendment to this registration statement:
(i) To include any prospectus required by
section 10(a)(3) of the Securities Act of 1933;
(ii) To reflect in the prospectus any facts
or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding
the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed
that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the
form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more
than 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in
the effective registration statement.
(iii) To include any material information
with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information
in the registration statement;
provided, however, that paragraphs (a)(1)(i),
(a)(1)(ii) and (a)(1)(iii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs
is contained in reports filed with or furnished to the SEC by the registrant pursuant to Section 13 or Section 15(d) of the Exchange Act
that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b)
that is part of the registration statement.
(2) That, for the purpose of determining any
liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof.
(3) To remove from registration by means of
a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(4) That, for the purpose of determining liability
under the Securities Act of 1933 to any purchaser:
(A) Each prospectus filed by the registrant
pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed
part of and included in the registration statement; and
(B) Each prospectus required to be filed pursuant
to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made
pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by section 10(a) of the Securities
Act of 1933 shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus
is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus.
As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall
be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that
prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided,
however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document
incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement
will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made
in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior
to such effective date; or
(5) That, for the purpose of determining liability
of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities, the undersigned registrant
undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless
of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means
of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or
sell such securities to such purchaser:
(i) Any preliminary prospectus or prospectus
of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;
(ii) Any free writing prospectus relating
to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;
(iii) The portion of any other free writing
prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or
on behalf of the undersigned registrant; and
(iv) Any other communication that is an offer
in the offering made by the undersigned registrant to the purchaser.
(b) The undersigned registrant hereby undertakes
that for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report pursuant
to section 13(a) or section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan’s annual report
pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed
to be the initial bona fide offering thereof.
(c) Insofar as indemnification for liabilities
arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to
the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against
public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities
(other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection
with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed
in the Act and will be governed by the final adjudication of such issue.
(d) The undersigned registrant hereby undertakes
that:
(1) For purposes of determining any liability
under the Securities Act of 1933, the information omitted from the form of prospectus filed as part of this registration statement in
reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or
497(h) under the Securities Act of 1933 shall be deemed to be part of this registration statement as of the time it was declared effective.
(2) For the purpose of determining any liability
under the Securities Act of 1933, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide offering thereof.
SIGNATURES
Pursuant to the requirements of the Securities
Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the
City of Boca Raton, State of Florida, on August 2, 2024.
|
INmune Bio Inc. |
|
|
|
|
By: |
/s/ Raymond J. Tesi, M. D. |
|
|
Raymond J. Tesi, M. D. |
|
Its: |
Chief Executive Officer |
|
|
(Principal Executive Officer) |
|
|
|
|
By: |
/s/ David J. Moss |
|
|
David J. Moss |
|
Its: |
Chief Financial Officer |
|
|
(Principal Financial and Accounting Officer) |
Each person whose signature appears below constitutes
and appoints Raymond J. Tesi and David J. Moss, and each of them severally, as his true and lawful attorney in fact and agent, with full
powers of substitution and re-substitution, for him and in his name, place and stead, in any and all capacities, to sign any or all amendments
(including post effective amendments) to the Registration Statement, and to sign any registration statement for the same offering covered
by this Registration Statement that is to be effective upon filing pursuant to Rule 462(b) under the Securities Act of 1933, as amended,
and all post effective amendments thereto, and to file the same, with all exhibits thereto, and all documents in connection therewith,
with the SEC, granting unto said attorney-in-fact and agent, each acting alone, full power and authority to do and perform each and every
act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or
could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, each acting alone, or his or her substitute
or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities
Act of 1933, this registration statement has been signed below by the following persons in the capacities and on the dates indicated.
/s/
Raymond J. Tesi, M.D |
|
August 2,
2024 |
Raymond J. Tesi, M.D.
|
|
|
Chief Executive Officer and
Director (principal executive officer) |
|
|
|
|
|
/s/
David J. Moss |
|
August 2, 2024 |
David J. Moss |
|
|
Chief Financial Officer
(principal financial and accounting officer) |
|
|
|
|
|
/s/
Timothy Schroeder |
|
August 2, 2024 |
Timothy Schroeder |
|
|
Director |
|
|
|
|
|
/s/
J. Kelly Ganjei |
|
August 2, 2024 |
J. Kelly Ganjei |
|
|
Director |
|
|
|
|
|
/s/
Scott Juda, JD |
|
August 2, 2024 |
Scott Juda, JD |
|
|
Director |
|
|
|
|
|
/s/
Marcia Allen |
|
August 2, 2024 |
Marcia Allen |
|
|
Director |
|
|
II-6
Exhibit 5.1
![](https://www.sec.gov/Archives/edgar/data/1711754/000121390024064719/ex5-1_001.jpg)
August 2,
2024
INmune Bio Inc.
225 NE Mizner Blvd, Suite 640
Boca Raton, FL 33432
| Re: | Registration Statement on Form S-3 |
Ladies and Gentlemen:
We have acted as counsel to INmune Bio Inc., a
Nevada corporation (the “Company”), in connection with the filing of a registration statement on Form S-3 (the “Registration
Statement”), under the Securities Act of 1933, as amended (the “Act”), relating to the offering and sale from time to
time, as set forth in the Registration Statement, the form of prospectus contained therein (the “Prospectus”), and one or
more supplements to the Prospectus (each, a “Prospectus Supplement”), by the Company of up to $250,000,000 aggregate initial
offering price of securities consisting of (i) shares of the Company’s common stock, par value $0.001 per share (the “Common
Stock”), (ii) shares of the Company’s preferred stock, par value $0.001 per share (the “Preferred Stock”), (iii)
warrants (“Warrants”) to purchase Common Stock or Preferred Stock, or (iv) units consisting of Common Stock, Preferred Stock,
or Warrants, or any combination thereof, in one or more series (the “Units”). The Common Stock, Preferred Stock, Warrants
and Units are collectively referred to herein as the “Securities.”
We have examined originals or certified copies
of such corporate records of the Company and other certificates and documents of officials of the Company, public officials and others
as we have deemed appropriate for purposes of this letter. We have assumed the genuineness of all signatures, the legal capacity of each
natural person signing any document reviewed by us, the authority of each person signing in a representative capacity (other than the
Company) any document reviewed by us, the authenticity of all documents submitted to us as originals and the conformity to authentic original
documents of all copies submitted to us or filed with the Securities and Exchange Commission (the “Commission”) as conformed
and certified or reproduced copies. As to any facts material to our opinion, we have made no independent investigation of such facts and
have relied, to the extent that we deem such reliance proper, upon certificates of public officials and officers or other representatives
of the Company.
Based upon the foregoing and subject to the assumptions,
exceptions, qualifications and limitations set forth herein, we are of the opinion that:
1. With respect to Securities constituting Common
Stock to be sold by the Company, when (i) the Company has taken all necessary action to authorize and approve the issuance of such Common
Stock, the terms of the offering thereof and related matters and (ii) such Common Stock has been issued and delivered, with certificates
representing such Common Stock having been duly executed, countersigned, registered and delivered or, if uncertificated, valid book-entry
notations therefor having been made in the share register of the Company, in accordance with the terms of the applicable definitive purchase,
underwriting or similar agreement or, if such Common Stock is issuable upon the exercise of Warrants, the applicable warrant agreement
therefor, against payment (or delivery) of the consideration therefor provided for therein, such Common Stock (including any Common Stock
duly issued upon exercise of Warrants that are exercisable to purchase Common Stock) will have been duly authorized and validly issued
and will be fully paid and non-assessable.
1185 Avenue of the Americas
| 31st Floor | New York, NY | 10036
T (212) 930 9700 | F (212) 930 9725 | WWW.SRFC.LAW
2. With respect to Securities constituting Preferred
Stock, when (i) the Company has taken all necessary action to authorize and approve the issuance and terms of the shares of the series
of such Preferred Stock, the terms of the offering thereof and related matters, including the adoption of a resolution fixing the number
of shares in any series of Preferred Stock and the designation of relative rights, preferences and limitations in any series of Preferred
Stock and the filing of a certificate of designation with respect to the series with the Secretary of State of the State of Nevada as
required by 78.1955 of the Nevada Revised Statutes and (ii) such Preferred Stock has been issued and delivered, with certificates representing
such Preferred Stock having been duly executed, countersigned, registered and delivered or, if uncertificated, valid book-entry notations
therefor having been made in the share register of the Company, in accordance with the terms of the applicable definitive purchase, underwriting
or similar agreement or, if such Preferred Stock is issuable upon the exercise of Warrants, the applicable warrant agreement therefor,
against payment (or delivery) of the consideration therefor provided for therein, such Preferred Stock (including any Preferred Stock
duly issued upon exercise of Warrants that are exercisable to purchase Preferred Stock) will have been duly authorized and validly issued
and will be fully paid and non-assessable.
3. With respect to the Warrants, when (i) the Board
of Directors of the Company (the “Board”) has taken all necessary corporate action to approve the creation of and the issuance
and terms of the Warrants, the terms of the offering thereof and related matters; (ii) the warrant agreement or agreements relating to
the Warrants have been duly authorized and validly executed and delivered by the Company and the warrant agent appointed by the Company;
and (iii) the Warrants or certificates representing the Warrants have been duly executed, countersigned, registered and delivered in accordance
with the appropriate warrant agreement or agreements and the applicable definitive purchase, underwriting or similar agreement approved
by the Board, upon payment of the consideration therefor provided for therein, the Warrants will be validly issued and will be valid and
binding obligations of the Company, enforceable against the Company in accordance with their terms.
4. With respect to Securities constituting Units,
when (i) the Board has taken all necessary corporate action to approve the creation of and the issuance and terms of the Units, terms
of the offering thereof and related matters; (ii) the agreement or agreements relating to the Securities comprising the Units have been
duly authorized and validly executed and delivered by the Company; and (iii) the certificates representing the Securities comprising the
Units have been duly executed, countersigned, registered and delivered in accordance with the appropriate agreements, the Units will be
valid and binding obligations of the Company enforceable against the Company in accordance with the their terms.
The opinions and other matters in this letter are
qualified in their entirety and subject to the following:
A. With respect to the opinions above, we have
assumed that, in the case of each offering and sale of Securities, (i) the Registration Statement, and any amendments thereto (including
post-effective amendments), will have become effective under the Act and such effectiveness or qualification shall not have been terminated
or rescinded; (ii) a Prospectus Supplement will have been prepared and filed with the Commission describing such Securities; (iii) such
Securities will have been issued and sold in compliance with applicable United States federal and state securities Laws (hereinafter defined)
and pursuant to and in the manner stated in the Registration Statement and the applicable Prospectus Supplement; (iv) unless such Securities
constitute Common Stock or Preferred Stock issuable upon exchange or conversion of Securities constituting Common Stock or Preferred Stock,
or Common Stock or Preferred Stock issuable upon exercise of Warrants, a definitive purchase, underwriting or similar agreement with respect
to the issuance and sale of such Securities will have been duly authorized, executed and delivered by the Company and the other parties
thereto; (v) at the time of the issuance of such Securities, (a) the Company will validly exist and be duly qualified and in good standing
under the laws of its jurisdiction of incorporation and (b) the Company will have the necessary corporate power and due authorization;
(vi) the terms of such Securities and of their issuance and sale will have been established in conformity with and so as not to violate,
or result in a default under or breach of, the articles of incorporation and bylaws of the Company and any applicable law or any agreement
or instrument binding upon the Company and so as to comply with any requirement or restriction imposed by any court or governmental or
regulatory body having jurisdiction over the Company; (vii) if such Securities constitute Common Stock or Preferred Stock, (a) sufficient
shares of Common Stock or Preferred Stock will be authorized for issuance under the articles of incorporation of the Company that have
not otherwise been issued or reserved for issuance and (b) the consideration for the issuance and sale of such Common Stock or Preferred
Stock established by the Board and provided for in the applicable definitive purchase, underwriting or similar agreement (or, if Common
Stock or Preferred Stock is issuable upon exercise of Warrants, the applicable warrant agreement) will not be less than the par value
of such Common Stock or Preferred Stock; (viii) if such Securities constitute Common Stock or Preferred Stock issuable upon exercise of
Warrants, the action with respect to such Warrants referred to in Paragraph 3 above will have been taken; and (ix) if such Securities
constitute Warrants that are exercisable for Securities constituting Common Stock or Preferred Stock, the Company will have then taken
all necessary action to authorize and approve the issuance of such Common Stock or Preferred Stock upon exercise of such Warrants, the
terms of such exercise and related matters and to reserve such Common Stock or Preferred Stock for issuance upon such exercise.
1185 Avenue of the Americas
| 31st Floor | New York, NY | 10036
T (212) 930 9700 | F (212) 930 9725 | WWW.SRFC.LAW
B.
This letter is limited to matters governed by the Nevada Revised Statutes and by the laws of the State of New York (“Laws”).
C. This letter is limited to the matters stated
herein, and no opinion is implied or may be inferred beyond the matters expressly stated. We assume herein no obligation, and hereby disclaim
any obligation, to make any inquiry after the date hereof or to advise you of any future changes in the foregoing or of any fact or circumstance
that may hereafter come to our attention.
D. The matters expressed in this letter are subject
to and qualified and limited by (i) applicable bankruptcy, insolvency, fraudulent transfer and conveyance, reorganization, moratorium
and similar laws affecting creditors’ rights and remedies generally, and (ii) general principles of equity, including principles
of commercial reasonableness, good faith and fair dealing (regardless of whether enforcement is sought in a proceeding at law or in equity).
We hereby consent to the filing of this opinion
as Exhibit 5.1 to the Registration Statement and to the use of our name under the caption “Legal Matters” in the Registration
Statement and in the Prospectus and in any supplement thereto. In giving this consent, we do not thereby admit that we are within the
category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission promulgated thereunder.
|
Very truly yours, |
|
|
|
/s/ Sichenzia Ross Ference Carmel LLP |
|
Sichenzia Ross Ference Carmel LLP |
1185 Avenue of the Americas
| 31st Floor | New York, NY | 10036
T (212) 930 9700 | F (212) 930 9725 | WWW.SRFC.LAW
3
Exhibit 23.1
Independent
Registered Public Accounting Firm’s Consent
We consent to the incorporation by reference in
this Registration Statement of INmune Bio Inc. on Form S-3 (Amendment No. 1) (File No. 333-279036) of our report dated March 28, 2024,
which includes an explanatory paragraph as to INmune Bio Inc.’s ability to continue as a going concern, with respect to our audits
of the consolidated financial statements of INmune Bio Inc. as of December 31, 2023 and 2022 and for the years ended December 31, 2023
and 2022 appearing in the Annual Report on Form 10-K of INmune Bio Inc. for the year ended December 31, 2023. We also consent to
the reference to our firm under the heading “Experts” in the Prospectus, which is part of this Registration Statement.
/s/ Marcum llp
Marcum llp
Houston, Texas
August 2, 2024
Exhibit 107
Calculation
of Filing Fee Tables
Form S-3
(Form Type)
INmune Bio Inc.
(Exact name of Registrant as Specified in its Charter)
| |
Security
Type | |
Security
Class Title | |
Fee
Calculation or Carry Forward Rule | |
Amount
Registered | | |
Proposed
Maximum Offering Price Per Unit | | |
Maximum
Aggregate Offering Price | | |
Fee
Rate | | |
Amount
of Registration Fee | | |
Carry
Forward Form Type | | |
Carry
Forward File Number | | |
Carry
Forward Initial effective date | | |
Filing
Fee Previously Paid In Connection with Unsold Securities to
be Carried Forward | |
Newly
Registered Securities | |
Fees
to Be Paid | |
Equity | |
Common
Stock, par value $0.001 per share | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| | | |
| | | |
| | | |
| | |
| |
Equity | |
Preferred
Stock, par value $0.001 per share | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| | | |
| | | |
| | | |
| | |
| |
Other | |
Warrants | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| | | |
| | | |
| | | |
| | |
| |
Other | |
Units | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| | | |
| | | |
| | | |
| | |
| |
Total | |
Unallocated
(Universal) Shelf | |
Rule
457(o) | |
| | (1) | |
| (2 | ) | |
$ | 56,169,401.90 | | |
| 0.00014760 | | |
$ | 8,290.61 | | |
| | | |
| | | |
| | | |
| | |
Carry
Forward Securities | |
Carry
Forward Securities | |
Equity | |
Common
Stock, par value $0.001 per share | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | |
| |
Equity | |
Preferred
Stock, par value $0.001 per share | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | |
| |
Other | |
Warrants | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | |
| |
Other | |
Units | |
— | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | | |
| — | |
| |
Total | |
Unallocated
(Universal) Shelf | |
Rule
415(a)(6) | |
| | (3) | |
| | | |
$ | 193,830,598.10 | | (3) |
| | | |
| | | |
| S-3 | | |
| 333-254221 | | |
| May
5, 2021 | | |
$ | 21,146.92 | (3) |
| |
Total
Offering Amounts | | |
$ | 250,000,000 | | |
| | | |
$ | 8,290.61 | | |
| | | |
| | | |
| | | |
| | |
| |
Total
Fees Previously Paid | | |
| | | |
| | | |
$ | 8,290.61 | | |
| | | |
| | | |
| | | |
| | |
| |
Total
Fee Offsets | | |
| | | |
| | | |
| — | | |
| | | |
| | | |
| | | |
| | |
| |
Net
Fee Due | | |
| | | |
| | | |
$ | 0.00 | | |
| | | |
| | | |
| | | |
| | |
| (1) | There are being registered hereunder such indeterminate number
of shares of common stock, such indeterminate number of shares of preferred stock, such indeterminate number of units and such indeterminate
number of warrants to purchase common stock or preferred stock registered hereunder as shall have an aggregate initial offering price
not to exceed $250,000,000. The securities registered also include such indeterminate number of shares of common stock and preferred
stock as may be issued upon exercise of warrants or pursuant to the antidilution provisions of any such securities. In addition, pursuant
to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), the shares being registered hereunder include
such indeterminate number of shares of common stock and preferred stock as may be issuable with respect to the shares being registered
hereunder as a result of stock splits, stock dividends or similar transactions. |
| (2) | The proposed maximum aggregate offering price per class of security
will be determined from time to time by INmune Bio Inc. (the “Registrant”) in connection with the issuance by the Registrant
of the securities registered hereunder and is not specified as to each class of security pursuant to Instruction 2.A.iii.b of the Instructions
to the Calculation of Filing Fee Tables and Related Disclosure on Form S-3. |
| (3) | The Registrant previously filed a Registration Statement on
Form S-3 with the Securities and Exchange Commission (the “SEC”) on March 12, 2021 (File No. 333-254221) (the “Prior
Registration Statement”), which was declared effective on May 5, 2021, that registered $250,000,000 of securities to be offered
by the Registrant from time to time. Pursuant to Rule 415(a)(6) under the Securities Act, this Registration Statement includes $193,830,598.10
of unsold securities (the “Unsold Securities”) that were previously registered on the Prior Registration Statement. In connection
with the registration of the Unsold Securities on the Prior Registration Statement, the Registrant paid a filing fee of $27,275 (calculated
at the filing fee rate in effect at the time of the filing of the Prior Registration Statement). The Registrant is not required to pay
any additional fee with respect to the Unsold Securities being included in this Registration Statement in reliance on Rule 415(a)(6),
because such Unsold Securities (and associated fees) are being moved from the Prior Registration Statement to this Registration Statement.
Accordingly, the Amount of Registration Fee in the table above reflects only the registration fee attributable to the $56,169,401.90
of new securities registered on this Registration Statement. The registration fee previously paid by the Registrant relating to the Unsold
Securities included on this Registration Statement will continue to be applied to such Unsold Securities. During the grace period afforded
by Rule 415(a)(5) under the Securities Act, the Registrant may continue to offer and sell under the Prior Registration Statement the
Unsold Securities being registered hereunder. To the extent that, after the filing date hereof and prior to the effectiveness of this
Registration Statement, the Registrant sells any such Unsold Securities pursuant to the Prior Registration Statement, the Registrant
will identify in a pre-effective amendment to this Registration Statement the updated amount of Unsold Securities from the Prior Registration
Statement to be included in this Registration Statement pursuant to Rule 415(a)(6). Pursuant to Rule 415(a)(6), the offering of the Unsold
Securities under the Prior Registration Statement will be deemed terminated as of the date of effectiveness of this Registration Statement. |
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