Can Fite: Namodenoson Inhibits Pancreatic Carcinoma Published in Leading Scientific Journal; Robust anti-Cancer Effect & Molecular Mechanism of Action
30 Octubre 2023 - 5:00AM
Business Wire
- These data support namodenoson as a leading drug candidate
to treat patients in an exploratory Phase II clinical
study
Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CANF), a
biotechnology company advancing a pipeline of proprietary small
molecule drugs that address oncology, inflammatory and liver
diseases, today announced that Biomolecules, a peer-reviewed
scientific journal focused on function and mechanism of bioactive
molecules, published an article titled “Namodenoson Inhibits the
Growth of Pancreatic Carcinoma via Deregulation of the
Wnt/β-catenin, NF-κB, and RAS Signaling Pathways”, authored by
Can-Fite’s CSO Dr. Pnina Fishman and others.
The article includes a summary on the robust inhibition of
pancreatic carcinoma growth, both in vitro and in vivo and a
definitive description of the molecular mechanism of action. The
latter includes de-regulation of three signal transduction pathways
known to play a pivotal role in the etiology and pathology of the
disease, including the Wnt, NF-kB and the RAS signalling pathway.
As a result, death of pancreatic carcinoma cells takes place via
apoptosis. This mechanism is highly important since pancreatic
carcinoma cells are resistant to the chemotherapy.
The Company is developing an exploratory Phase II study protocol
that is designed to allow treatment of patients with pancreatic
carcinoma who failed first line therapy. The study objectives will
include safety and efficacy of the Namodenoson drug.
Currently, Namodenoson is being evaluated in a pivotal Phase III
study that has been approved by both the U.S. Food and Drug
Administration (FDA) and the European Medicines Agency (EMA).
“We are very much encouraged by the excellent data in the
pre-clinical studies demonstrating the impressive anti-cancer
effect of Namodenoson against pancreatic carcinoma,” stated Dr.
Fishman, Can-Fite’s Chief Scientific Officer and Executive
Chairman. “We plan to start treating patients very shortly and hope
that Namodenoson, with its positive safety and efficacy profile,
will prolong life for pancreatic cancer patients.”
About Namodenoson
Namodenoson was evaluated in Phase II trials for two
indications, as a second line treatment for hepatocellular
carcinoma (HCC), and as a treatment for non-alcoholic fatty liver
disease (NAFLD) and non-alcoholic steatohepatitis (NASH). It is
currently in a Phase IIb trial for NASH and a pivotal Phase III for
HCC. Namodenoson is a small orally bioavailable drug that binds
with high affinity and selectivity to the A3 adenosine receptor
(A3AR). A3AR is highly expressed in diseased cells whereas low
expression is found in normal cells. This differential effect
accounts for the excellent safety profile of the drug.
About Can-Fite BioPharma Ltd.
Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CANF) is an
advanced clinical stage drug development Company with a platform
technology that is designed to address multi-billion dollar markets
in the treatment of cancer, liver, and inflammatory disease. The
Company's lead drug candidate, Piclidenoson recently reported
topline results in a Phase III trial for psoriasis. Can-Fite's
liver drug, Namodenoson, is being evaluated in a Phase IIb trial
for the treatment of non-alcoholic steatohepatitis (NASH), and
enrollment is expected to commence in a Phase III trial for
hepatocellular carcinoma (HCC), the most common form of liver
cancer. Namodenoson has been granted Orphan Drug Designation in the
U.S. and Europe and Fast Track Designation as a second line
treatment for HCC by the U.S. Food and Drug Administration.
Namodenoson has also shown proof of concept to potentially treat
other cancers including colon, prostate, and melanoma. CF602, the
Company's third drug candidate, has shown efficacy in the treatment
of erectile dysfunction. These drugs have an excellent safety
profile with experience in over 1,500 patients in clinical studies
to date. For more information please visit: www.can-fite.com.
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Can-Fite’s expectations, beliefs or intentions regarding, among
other things, its product development efforts, business, financial
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initiation, timing, progress and results of our preclinical
studies, clinical trials and other product candidate development
efforts; our ability to advance our product candidates into
clinical trials or to successfully complete our preclinical studies
or clinical trials; our receipt of regulatory approvals for our
product candidates, and the timing of other regulatory filings and
approvals; the clinical development, commercialization and market
acceptance of our product candidates; our ability to establish and
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our business and product candidates; the scope of protection we are
able to establish and maintain for intellectual property rights
covering our product candidates and our ability to operate our
business without infringing the intellectual property rights of
others; competitive companies, technologies and our industry; risks
related to the COVID-19 pandemic and the Russian invasion of
Ukraine; risks related to not satisfying the continued listing
requirements of NYSE American; and statements as to the impact of
the political and security situation in Israel on our business.
More information on these risks, uncertainties and other factors is
included from time to time in the “Risk Factors” section of
Can-Fite’s Annual Report on Form 20-F filed with the SEC on March
30, 2023 and other public reports filed with the SEC and in its
periodic filings with the TASE. Existing and prospective investors
are cautioned not to place undue reliance on these forward-looking
statements, which speak only as of the date hereof. Can-Fite
undertakes no obligation to publicly update or review any
forward-looking statement, whether as a result of new information,
future developments or otherwise, except as may be required by any
applicable securities laws.
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Can-Fite BioPharma Motti Farbstein info@canfite.com
+972-3-9241114
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