BFRG Bullfrog AI Holdings Inc

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

 

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

 

Date of Report (Date of earliest event reported): July 25, 2024

 

BULLFROG AI HOLDINGS, INC.

(Exact name of registrant as specified in charter)

 

Nevada		001-41600		84-4786155
(State or other jurisdiction		(Commission		(IRS Employer
of incorporation)		File Number)		Identification No.)

 

325 Ellington Blvd, Unit 317

Gaithersburg, MD 20878

(Address of principal executive offices) (Zip Code)

 

(240) 658-6710

(Registrant’s telephone number, including area code)

 

Not Applicable

(Former name or former address, if changed since last report)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Common Stock, par value $ 0.00001 per share		BFRG		The Nasdaq Stock Market LLC (The Nasdaq Capital Market)
Tradeable Warrants		BFRGW		The Nasdaq Stock Market LLC (The Nasdaq Capital Market)

 

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

 

Emerging growth ☒

 

If an emerging growth company, indicate by check mart if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

 

 

 

Item 7.01 Regulation FD Disclosure

 

On July 25, 2024, Bullfrog AI Holdings, Inc. issued a press release. A copy of the press release is attached hereto and incorporated herein by reference in its entirety as Exhibit 99.1.

 

Item 9.01 Financial statements and Exhibits

 

(d) Exhibits.

 

Exhibit Number		Description
Exhibit 99.1		Press Release dated July 25, 2024.
104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

 

 

SIGNATURE

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

Date: July 25, 2024

 

BULLFROG AI HOLDINGS, INC.
By:	/s/ Vininder Singh
	Vininder Singh
	Chief Executive Officer

 

 

Exhibit 99.1

 

BullFrog AI and Lieber Institute for Brain Development Reveal New Insights into Bipolar Disorder Pathways and Potential Drug Targets

 

Discussions underway for drug target discovery deals with potential pharma partners

 

GAITHERSBURG, Md., July 25, 2024 (GLOBE NEWSWIRE) -- BullFrog AI Holdings, Inc. (NASDAQ: BFRG; BFRGW) (“BullFrog AI” or the “Company”), a leader in AI-driven drug discovery, announced significant advancements in its ongoing collaboration with the Lieber Institute for Brain Development (LIBD). Building on the progress detailed in our May 16, 2024 release, our research has now pinpointed specific molecular pathways associated with bipolar disorder (BD), enabling the identification of new candidate drug targets.

 

Our latest analysis, focusing on functional enrichment across various brain regions associated with bipolar disorder, identified significant enrichment in six out of 68 clusters from the LIBD brain dataset. This means that six specific groups of genes or proteins, which are highly relevant to at least some cases with BD, were found among the many brain data clusters analyzed. This is significant because it narrows down gene networks most involved in BD, allowing for more targeted research.

 

One notable example, in the Dentate Gyrus, a region critical for memory and cognitive function, two substantially enriched clusters were discovered. This suggests a strong involvement of this area in BD pathology. Additionally, the Dorsolateral Prefrontal Cortex (DLPFC), which is crucial for executive functions like decision-making and problem-solving, revealed one specific cluster associated with BD. This precise identification within the DLPFC highlights a key area for understanding and potentially treating BD.

 

These findings highlight the potential dysregulation of pro-inflammatory pathways and include the identification of a number of novel pathways significant to the pathophysiology of BD. Our advanced AI-driven analysis not only deepens the understanding of BD but also identifies several putative drivers of the condition. These discoveries pave the way for developing targeted therapeutics aimed at these specific molecular mechanisms, offering hope for more effective and personalized treatments for patients suffering from BD.

 

Continued Collaboration and Future Directions:

 

“This collaboration continues to demonstrate the power of AI in unlocking the complexities of neuropsychiatric disorders,” said Vin Singh, CEO of BullFrog AI. “Our proprietary bfLEAP™ platform and causal AI strategy, combined with LIBD’s extensive brain data, is driving forward our mission to develop precise and effective treatments. We are now focusing on validating these findings in wet lab settings and engaging with pharmaceutical partners to advance these discoveries.”

 

Daniel R. Weinberger, M.D., Director and CEO of LIBD, added, “The insights gained from this collaboration are potentially instrumental in our understanding of bipolar disorder and its treatment. We are enthusiastic about the potential impact these findings could have on developing new targeted therapies that significantly improve patient outcomes.”

 

 

About the Lieber Institute for Brain Development (LIBD):

 

The Lieber Institute for Brain Development is dedicated to translating the understanding of genetic and molecular mechanisms of schizophrenia and related brain disorders into clinical advancements. The LIBD brain repository, with over 4,300 human brains, is the world’s largest collection for the study of neuropsychiatric disorders.

 

About BullFrog AI:

 

BullFrog AI leverages Artificial Intelligence and machine learning to advance drug discovery and development. Through collaborations with leading research institutions, BullFrog AI uses causal AI in combination with its proprietary bfLEAP™ platform to analyze complex biological data, aiming to streamline therapeutics development and reduce failure rates in clinical trials.

 

For more information, visit BullFrog AI at www.bullfrogai.com.

 

Safe Harbor Statement:

 

This press release contains forward-looking statements. We base these forward-looking statements on our expectations and projections about future events, which we derive from the information currently available to us. Such forward-looking statements relate to future events or our future performance, including: our financial performance and projections; our growth in revenue and earnings; and our business prospects and opportunities. You can identify forward-looking statements by those that are not historical in nature, particularly those that use terminology such as “may,” “should,” “expects,” “anticipates,” “contemplates,” “estimates,” “believes,” “plans,” “projected,” “predicts,” “potential,” or “hopes” or the negative of these or similar terms. In evaluating these forward-looking statements, you should consider various factors, including: our ability to change the direction of the Company; our ability to keep pace with new technology and changing market needs; and the competitive environment of our business. These and other factors may cause our actual results to differ materially from any forward-looking statement. Forward-looking statements are only predictions. The forward-looking events discussed in this press release and other statements made from time to time by us or our representatives, may not occur, and actual events and results may differ materially and are subject to risks, uncertainties, and assumptions about us. We are not obligated to publicly update or revise any forward-looking statement, whether as a result of uncertainties and assumptions, the forward-looking events discussed in this press release and other statements made from time to time by us or our

representatives might not occur.

 

Contact:

 

Investors

Dave Gentry RedChip Companies, Inc.

BFRG@redchip.com
1-407-644-4256

SOURCE: BullFrog AI Holdings, Inc.

 

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Entity Incorporation, State or Country Code	NV
Entity Address, Address Line One	325 Ellington Blvd
Entity Address, Address Line Two	Unit 317
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Common Stock, par value $ 0.00001 per share
Title of 12(b) Security	Common Stock, par value $ 0.00001 per share
Trading Symbol	BFRG
Security Exchange Name	NASDAQ
Tradeable Warrants
Title of 12(b) Security	Tradeable Warrants
Trading Symbol	BFRGW
Security Exchange Name	NASDAQ

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