Form 10-Q - Quarterly report [Sections 13 or 15(d)]

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

(Mark One)


☒			QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2024


☐			TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 001-38720

Twist Bioscience Corporation

(Exact Name of Registrant as Specified in its Charter)


Delaware			46-2058888
(State or other jurisdiction of			(I.R.S. Employer
incorporation or organization)			Identification No.)

681 Gateway Blvd, South San Francisco, CA 94080

(Address of principal executive offices and zip code)

(800) 719-0671

(Registrant’s telephone number, including area code)

Title of each class

Trading Symbol(s)

Name of each exchange on which registered

Common Stock

TWST

The Nasdaq Global Select Market

Indicate by check mark whether the Registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the Registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act. (Check one):


Large accelerated filer	☒	Accelerated filer	☐
Non-accelerated filer	☐	Smaller reporting company	☐
		Emerging growth company	☐

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY PROCEEDINGS DURING THE PRECEDING FIVE YEARS:

Indicate by check mark whether the registrant has filed all documents and reports required to be filed by Section 12, 13 or 15(d) of the Securities Exchange Act of 1934 subsequent to the distribution of securities under a plan confirmed by a court. Yes ☐ No ☐

APPLICABLE ONLY TO CORPORATE ISSUERS

Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date.

The number of shares of the Registrant’s common stock outstanding as of July 31, 2024, was 58,585,960.

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TWIST BIOSCIENCE CORPORATION

QUARTERLY REPORT ON FORM 10-Q

FOR THE QUARTER ENDED JUNE 30, 2024

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Forward-looking statements		2
PART I. Financial information		4
Item 1.	Unaudited Financial Statements	4
	Condensed Consolidated Balance Sheets (Unaudited)	4
	Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)	5
	Condensed Consolidated Statements of Stockholders’ Equity (Unaudited)	6
	Condensed Consolidated Statements of Cash Flows (Unaudited)	8
	Notes to Unaudited Condensed Consolidated Financial Statements	9
Item 2.	Management’s discussion and analysis of financial condition and results of operations	24
Item 3.	Quantitative and qualitative disclosures about market risk	33
Item 4.	Controls and procedures	33
PART II. Other information		34
Item 1.	Legal proceedings	34
Item 1A.	Risk factors	35
Item 2.	Unregistered sales of equity securities and use of proceeds	35
Item 3.	Defaults upon senior securities	35
Item 4.	Mine safety disclosures	35
Item 5.	Other information	35
Item 6.	Exhibits	36
Signatures		37

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Forward-looking statements

This Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, or Form 10-Q, contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act. These statements relate to, among other matters, plans for product development and licensing to third parties, plans and timeframe for the commercial development of DNA data storage capabilities, expectations regarding market penetration, anticipated customer conversions to our products, plans to expand in the international markets, and identification and development of potential antibody candidates. Forward-looking statements are also identified by the words “believe,” “will,” “may,” “estimate,” “continue,” “anticipate,” “intend,” “should,” “plan,” “expect,” “predict,” “could,” “potentially” and variations of such words and similar expressions. You should not rely upon forward-looking statements as predictions of future events. Such statements are based on management’s expectations as of the date of this filing and involve many risks and uncertainties that could cause our actual results, events or circumstances to differ materially from those expressed or implied in our forward-looking statements. Such risks and uncertainties include:

•our ability to increase our revenue and our revenue growth rate;

•our ability to accurately estimate capital requirements and our needs for additional financing; our estimates of the size of our market opportunities;

•our ability to increase DNA production, reduce turnaround times and drive cost reductions for our customers;

•our ability to effectively manage our growth;

•our ability to successfully enter new markets and manage our international expansion;

•our ability to develop and commercialize additional products in the synthetic biology, biologic drug and data storage industries, including our Express Genes product;

•our ability to leverage our investment in our manufacturing facility in Wilsonville, Oregon;

•our ability to protect our intellectual property, including our proprietary DNA synthesis platform;

•costs associated with defending intellectual property infringement and other claims;

•the effects of increased competition in our business;

•our ability to keep pace with changes in technology and our competitors;

•our ability to successfully identify, evaluate and manage any future acquisitions of businesses, solutions or technologies;

•the success of our marketing efforts;

•a significant disruption in, or breach in security of our information technology systems and resultant interruptions in service and any related impact on our reputation;

•our ability to attract and retain qualified employees and key personnel;

•the effects of natural or man-made catastrophic events or public health emergencies;

•the effectiveness of our internal controls;

•changes in government regulation affecting our business;

•uncertainty as to economic and market conditions and the impact of adverse economic conditions; and

•other risk factors included under the section titled “Risk factors” contained in Item 1A of our Annual Report on Form 10-K filed with the SEC on November 21, 2023, our Quarterly Report on Form 10-Q filed with the SEC on February 2, 2024 and this Quarterly Report on Form 10-Q.

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You should not rely upon forward-looking statements as predictions of future events. Such statements are based on management’s expectations as of the date of this filing and involve many risks and uncertainties that could cause our actual results, events or circumstances to differ materially from those expressed or implied in our forward-looking statements.

Readers are urged to carefully review and consider all of the information in this Form 10-Q and in other documents we file from time to time with the Securities and Exchange Commission, or SEC. We undertake no obligation to update any forward-looking statements made in this Form 10-Q to reflect events or circumstances after the date of this filing or to reflect new information or the occurrence of unanticipated events, except as required by law. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures or investments we may make.

When we use the terms “Twist,” “Twist Bioscience,” the “Company,” “we,” “us” or “our” in this report, we are referring to Twist Bioscience Corporation and its consolidated subsidiaries unless the context requires otherwise. Sequence space and the Twist logo are trademarks of Twist Bioscience Corporation. All other company and product names may be trademarks of the respective companies with which they are associated.

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PART I. Financial information

Item 1. Financial statements

Twist Bioscience Corporation

Condensed Consolidated Balance Sheets (unaudited)


(In thousands except per share data)	June 30, 2024		September 30, 2023
Assets
Current assets:
Cash and cash equivalents	$	239,142	$	286,470
Short-term investments	50,276		49,943
Accounts receivable, net	31,988		44,064
Inventories	28,484		32,063
Prepaid expenses and other current assets	11,941		11,716
Total current assets	$	361,831	$	424,256
Property and equipment, net	106,339		131,830
Operating lease right-of-use assets	61,277		71,531
Goodwill	85,811		85,811
Intangible assets, net	14,741		54,483
Restricted cash, non-current	2,895		2,811
Other non-current assets	5,224		5,681
Total assets	$	638,118	$	776,403
Liabilities and stockholders’ equity
Current liabilities:
Accounts payable	$	6,626	$	14,052
Accrued expenses	14,838		10,754
Accrued compensation	31,659		25,818
Current portion of operating lease liability	14,555		14,896

Other current liabilities	6,079		7,803
Total current liabilities	$	73,757	$	73,323
Operating lease liability, net of current portion	72,625		79,173
Other non-current liabilities	597		475
Total liabilities	$	146,979	$	152,971
Commitments and contingencies (Note 6)
Stockholders’ equity
Common stock, $0.00001 par value —100,000 and 100,000 shares authorized at June 30, 2024 and September 30, 2023, respectively; 58,519 and 57,557 shares issued and outstanding at June 30, 2024 and September 30, 2023, respectively	$	—	$	—
Additional paid-in capital	1,699,127		1,657,222
Accumulated other comprehensive income	(735)		(756)
Accumulated deficit	(1,207,253)		(1,033,034)
Total stockholders’ equity	$	491,139	$	623,432
Total liabilities and stockholders’ equity	$	638,118	$	776,403

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

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Twist Bioscience Corporation

Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited)


	Three months ended June 30,				Nine months ended June 30,
(In thousands, except per share data)	2024		2023		2024		2023
Revenues [1]	$	81,464	$	63,740	$	228,264	$	178,163
Operating expenses:
Cost of revenues	$	46,193	$	41,845	$	133,148	$	112,956
Research and development	22,469		24,528		69,718		83,148
Selling, general and administrative	56,794		46,057		165,256		142,347
Restructuring and other costs	—		9,052		—		9,052
Impairment of long-lived assets	44,930		3,620		44,930		3,620
Change in fair value of contingent considerations and holdbacks	—		(581)		—		(5,913)
Total operating expenses	$	170,386	$	124,521	$	413,052	$	345,210
Loss from operations	$	(88,922)	$	(60,781)	$	(184,788)	$	(167,047)
Interest income	3,663		3,968		11,724		10,472
Interest expense	—		(1)		—		(4)
Other income (expense), net	(121)		41		(351)		(422)
Loss before income taxes	$	(85,380)	$	(56,773)	$	(173,415)	$	(157,001)
Income tax provision	(191)		(622)		(656)		(1,374)
Net loss attributable to common stockholders	$	(85,571)	$	(57,395)	$	(174,071)	$	(158,375)
Other comprehensive loss:
Change in unrealized gain (loss) on investments	(21)		(208)		56		1,308
Foreign currency translation adjustment	(54)		(538)		(35)		(100)
Comprehensive loss	(85,646)		(58,141)		(174,050)		(157,167)
Net loss per share attributable to common stockholders—basic and diluted	$	(1.47)	$	(1.01)	$	(3.01)	$	(2.79)
Weighted average shares used in computing net loss per share attributable to common stockholders—basic and diluted	58,145		57,041		57,806		56,753

[1] During the three and nine months ended June 30, 2024, the Company generated revenues from related parties totaling of $4.1 million and $9.7 million, respectively. During the three and nine months ended June 30, 2023, the Company generated revenues from related parties totaling $0.9 million and $3.6 million, respectively.

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

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Twist Bioscience Corporation

Condensed Consolidated Statements of Stockholders’ Equity (unaudited)


	Three months ended June 30, 2024
	Common stock			Additional paid-in capital		Accumulated Other comprehensive loss		Accumulated deficit		Total stockholders' equity
(In thousands)	Shares	Amount
Balances as of March 31, 2024	58,162	$	—	$	1,682,473	$	(660)	$	(1,121,682)	$	560,131
Vesting of restricted stock units	223	$	—	$	—	$	—	$	—	$	—
Exercise of stock options	134	—		2,915		—		—		2,915

Repurchases of common stock for income tax withholding	—	—		(7)		—		—		(7)
Stock-based compensation	—	—		13,746		—		—		13,746
Other comprehensive income	—	—		—		(75)		—		(75)
Net loss	—	—		—		—		(85,571)		(85,571)
Balances as of June 30, 2024	58,519	$	—	$	1,699,127	$	(735)	$	(1,207,253)	$	491,139


	Three months ended June 30, 2023
	Common stock			Additional paid-in capital		Accumulated Other comprehensive income		Accumulated deficit		Total stockholders' equity
(In thousands)	Shares	Amount
Balances as of March 31, 2023	57,105	$	—	$	1,633,217	$	111	$	(929,396)	$	703,932
Vesting of restricted stock units	182	$	—	$	—	$	—	$	—	$	—
Exercise of stock options	45	—		342		—		—		342

Repurchases of common stock for income tax withholding	(70)	—		(1,014)		—		—		(1,014)
Issuance of shares from business acquisition	105	—		1,767		—		—		1,767
Stock-based compensation	—	—		10,664		—		—		10,664
Other comprehensive income	—	—		—		(746)		—		(746)
Net loss	—	—		—		—		(57,395)		(57,395)
Balances as of June 30, 2023	57,367	$	—	$	1,644,976	$	(635)	$	(986,791)	$	657,550

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

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	Nine months ended June 30, 2024
	Common stock			Additional paid-in capital		Accumulated Other comprehensive loss		Accumulated deficit		Total stockholders' equity
(In thousands)	Shares	Amount
Balances as of September 30, 2023	57,557	$	—	$	1,657,222	$	(756)	$	(1,033,034)	$	623,432
Impact of ASU 2016-13 adoption (Note 2)	—	$	—	$	—	$	—	$	(148)	$	(148)
Vesting of restricted stock units	712	—		—		—		—		—
Exercise of stock options	261	—		5,183		—		—		5,183
Issuance of shares under the employee stock purchase program	124	—		2,047		—		—		2,047
Repurchases of common stock for income tax withholding	(135)	—		(3,967)		—		—		(3,967)
Stock-based compensation	—	—		38,642		—		—		38,642
Other comprehensive income	—	—		—		21		—		21
Net loss	—	—		—		—		(174,071)		(174,071)
Balances as of June 30, 2024	58,519	$	—	$	1,699,127	$	(735)	$	(1,207,253)	$	491,139


	Nine months ended June 30, 2023
	Common stock			Additional paid-in capital		Accumulated Other comprehensive income		Accumulated deficit		Total stockholders' equity
(In thousands)	Shares	Amount
Balances as of September 30, 2022	56,523	$	—	$	1,619,644	$	(1,843)	$	(828,416)	$	789,385
Vesting of restricted stock units	504	$	—	$	—	$	—	$	—	$	—
Exercise of stock options	102	—		1,195		—		—		1,195
Issuance of shares under the employee stock purchase plan	132	—		2,536		—		—		2,536
Repurchases of common stock for income tax withholding	(171)	—		(3,275)		—		—		(3,275)
Issuance of shares from business acquisition	277	—		5,860		—		—		5,860
Stock-based compensation	—	—		19,016		—		—		19,016
Other comprehensive income	—	—		—		1,208		—		1,208
Net loss	—	—		—		—		(158,375)		(158,375)
Balances as of June 30, 2023	57,367	$	—	$	1,644,976	$	(635)	$	(986,791)	$	657,550

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

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Twist Bioscience Corporation

Condensed Consolidated Statements of Cash Flows (unaudited)


	Nine months ended June 30,
(in thousands)	2024		2023
Cash flows from operating activities
Net loss	$	(174,071)	$	(158,375)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization	24,776		20,810
Impairment of long-lived assets	44,930		3,620
Non-cash lease expense	647		1,040
Stock-based compensation	38,578		18,531
Change in fair value of acquisition consideration	—		(5,913)
Other non-cash adjustments	(185)		(33)
Changes in assets and liabilities:
Accounts receivable, net	11,398		(2,508)
Inventories	3,578		2,949
Prepaid expenses and other current assets	(185)		(1,935)
Other non-current assets	472		1,050
Accounts payable	(6,927)		(4,431)
Accrued expenses	4,132		1,278
Accrued compensation	5,932		348
Other liabilities	(1,849)		1,799
Net cash used in operating activities	$	(48,774)	$	(121,770)
Cash flows from investing activities
Purchases of property and equipment	$	(3,074)	$	(25,386)
Purchases of investments	(30,712)		(58,255)
Proceeds from maturity of investments	32,000		136,500
Net cash (used in) provided by investing activities	$	(1,786)	$	52,859
Cash flows from financing activities
Proceeds from exercise of stock options	$	5,183	$	1,208
Proceeds from issuance of common stock under employee stock purchase plan	2,047		2,536
Repurchases of common stock for income tax withholding	(3,967)		(3,275)
Net cash provided by financing activities	$	3,263	$	469
Effect of exchange rates on cash, cash equivalents and restricted cash	$	53	$	21
Net decrease in cash, cash equivalents, and restricted cash	(47,244)		(68,421)
Cash, cash equivalents, and restricted cash at beginning of period	289,281		380,259
Cash, cash equivalents, and restricted cash at end of period	$	242,037	$	311,838
Supplemental disclosure of cash flow information

Income taxes paid, net of refunds	$	363	$	241
Non-cash investing and financing activities
Property and equipment additions included in accounts payable and accrued expenses	$	226	$	1,686
Operating lease right-of-use assets obtained in exchange for operating lease liabilities	—		4,215
Issuance of common stock in connection with the business acquisition	—		5,860
Tenant improvement allowance capitalized in property and equipment	2,719		—
Conversion of convertible notes	—		3,711

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

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Twist Bioscience Corporation

Notes to Unaudited Condensed Consolidated Financial Statements

1. The Company

Twist Bioscience Corporation (the Company) was incorporated in the state of Delaware on February 4, 2013. The Company is a synthetic biology and genomics company that has developed a disruptive DNA synthesis platform. DNA is used in many applications across different industries: industrial chemicals/materials, academic, healthcare and food/agriculture. The Company’s fiscal year ends on September 30.

The core of the Company’s platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. The Company has combined this technology with proprietary software, scalable commercial infrastructure and an e-commerce platform to create an integrated technology platform that enables the Company to achieve high levels of quality, precision, automation, and manufacturing throughput at a significantly lower cost than its competitors. The Company is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next generation sample preparation, and antibody libraries for drug discovery and development.

The Company has a limited operating history and its prospects are subject to risks, expenses and uncertainties frequently encountered by companies in this industry. These risks include, but are not limited to, the uncertainty of availability of additional financing, market acceptance of its products, the ability to retain and attract new customers, and the uncertainty of achieving future profitability.

The Company has generated net losses in all periods since its inception. As of June 30, 2024, the Company had an accumulated deficit of $1,207.3 million and has not generated positive cash flows from operations since inception. Losses are expected to continue as the Company continues to invest in product development, manufacturing, and sales and marketing.

As of June 30, 2024, the Company had cash and cash equivalents and short-term investments of $289.4 million, which the management believes will be sufficient to fund operations for at least one year from the issuance of these consolidated financial statements. However, if the Company needs to obtain additional financing to fund operations beyond this period, there can be no assurance that it will be successful in raising additional financing on terms which are acceptable to the Company.

If the Company requires but is unable to obtain additional funding, the Company could be forced to delay, reduce or eliminate some or all of its research and development programs, product portfolio expansion or commercialization efforts, which could adversely affect its business prospects, or the Company may be unable to continue operations.

2. Summary of significant accounting policies

Basis of presentation and use of estimates

The accompanying unaudited condensed consolidated financial statements were prepared in accordance with accounting principles generally accepted in the United States of America (GAAP) for interim financial information. Certain information and disclosures normally included in the consolidated financial statements prepared in accordance with GAAP have been condensed or omitted. Accordingly, these unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the related notes included in the Annual Report on Form 10-K for the fiscal year ended September 30, 2023 (the Annual Report on Form 10-K) filed with the Securities and Exchange Commission on November 21, 2023. The condensed consolidated financial statements are unaudited and have been prepared on a basis consistent with that used to prepare the audited annual consolidated financial statements and include, in the opinion of management, all adjustments, consisting of normal and recurring items, necessary for the fair statement of the condensed consolidated financial statements. The condensed consolidated balance sheet at September 30, 2023 is derived from audited consolidated financial statements but does not include all disclosures required by GAAP. The operating results for the three and nine months ended June 30, 2024 are not necessarily indicative of the results expected for the full year ending September 30, 2024 or any interim period.

The presentation of unaudited condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the condensed consolidated financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates. The Company’s unaudited

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condensed consolidated financial statements include its wholly owned subsidiaries. All intercompany balances and accounts are eliminated in consolidation.

To conform with current fiscal 2024 presentation, we reclassified $3.6 million of impairment of property and equipment included within restructuring and other costs to impairment of long-lived assets in the condensed consolidated statement of operations and comprehensive loss for the three and nine months ended June 30, 2023. This reclassification had no impact on our condensed statement of operations and comprehensive loss for the three and nine months ended June 30, 2023.

The following table provides a reconciliation of the Company’s cash and cash equivalents and non-current portion of restricted cash reported within the unaudited condensed consolidated balance sheets that sum to the total cash, cash equivalents and restricted cash shown in the Company’s condensed consolidated statements of cash flows:


(in thousands)	June 30, 2024		September 30, 2023
Cash and cash equivalents	$	239,142	$	286,470
Restricted cash, non-current	2,895		2,811
Total cash, cash equivalents and restricted cash	$	242,037	$	289,281

Restricted cash represents cash held at financial institutions that are pledged as collateral for stand-by letters of credit for lease commitments and is included in non-current assets.

Significant accounting policies

There have been no material changes in the accounting policies from those disclosed in the audited consolidated financial statements and the related notes included in the Annual Report on Form 10-K other than disclosed below.

Allowance for Credit Losses

The Company maintains an allowance for credit losses for expected uncollectible accounts receivable and contract assets, which is recorded as an offset to accounts receivable or contract assets and provisions for credit losses are recorded in general and administrative expense in the consolidated statements of income. Under the application of Accounting Standards Codification (“ASC”) Topic 326-20, Financial Instruments—Credit Losses (“ASC 326”), the allowance for current expected credit losses is based on a review of customer accounts and considers historical credit loss information that is adjusted for current economic and business conditions and anticipated future economic events that may impact collectability. In developing its expected credit loss estimate, the Company evaluated the appropriate grouping of accounts receivable and contract assets based upon its evaluation of risk characteristics, including consideration of region and industries of the customers. The allowance for credit losses is reviewed on a quarterly basis to assess the adequacy of the allowance. Allowance for credit losses was $0.7 million as of June 30, 2024.

Short-term investments

The Company invests in various types of securities, including United States government, commercial paper, and corporate debt securities. The Company classifies its investments as available-for-sale and records them at fair value based upon market prices at period end. For available-for-sale debt securities in an unrealized loss position, the Company evaluates whether a current expected credit loss exists based on available information relevant to the credit rating of the security, current economic conditions and reasonable and supportable forecasts. The allowance for credit loss is recorded in other income (expense), net, on the consolidated statements of income, not to exceed the amount of the unrealized loss. Any excess unrealized loss other than the credit loss is recognized in accumulated other comprehensive income or loss in the stockholders' equity section of the consolidated balance sheets. The cost of securities sold is based on the specific identification method and realized gains and losses are included in other income (expense), net. Dividend and interest income are recognized when earned. The Company may sell these securities at any time for use in current operations. There was no allowance for credit losses relating to the short-term investments recognized as of June 30, 2024.

Revenue

The Company had contract assets of $2.6 million and contract liabilities of $2.9 million as of June 30, 2024. The Company had contract assets of $2.8 million and contract liabilities of $3.0 million as of September 30, 2023. For the three and nine months ended June 30, 2024, the Company recognized revenue of $0.7 million and $2.9 million, respectively, from the amount that was included in the contract liability balance at the beginning of each period. For the three and nine months ended June 30, 2023, the Company recognized revenue of $0.6 million and $2.8 million, respectively, from the amount that was included in the contract liability balance at the beginning of each period. In addition, for all periods presented, there

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was no revenue recognized in a reporting period from performance obligations satisfied in previous periods. The aggregate amount of the transaction price allocated to the performance obligations that are unsatisfied as of June 30, 2024 was $7.1 million. The Company expects to recognize revenue over the next twelve months relating to performance obligations unsatisfied as of June 30, 2024.

Based on the nature of the Company's contracts with customers, which are recognized over a term of less than 12 months, the Company has elected to use the practical expedient whereby costs to obtain a contract are expensed as they are incurred.

The Company states its revenues net of any taxes collected from customers that are required to be remitted to various government agencies. The amount of taxes collected from customers and payable to governmental entities is included on the balance sheet as part of “Accrued expenses and other current liabilities.”

Recent accounting pronouncements

Changes to GAAP are established by the Financial Accounting Standards Board (“FASB”) in the form of accounting standards updates (“ASUs”) to the FASB’s ASC. The Company considered the applicability and impact of all recent ASUs. ASUs not listed below were assessed and determined to be not applicable to the Company’s consolidated financial position and results of operations.

Recent accounting pronouncements adopted

In June 2016, FASB issued ASU No. 2016-13 “Financial Instruments-Credit Losses: Measurement of Credit Losses on Financial Instruments” and has since modified the standard with several ASUs (collectively, “Topic 326”). Topic 326 requires measurement and recognition of expected credit losses for financial assets. The ASU replaced previous incurred loss impairment guidance and established a single expected credit losses allowance framework for financial assets carried at amortized cost. It also eliminated the concept of other-than-temporary impairment and requires credit losses related to certain available-for-sale debt securities to be recorded through an allowance for credit losses. On October 1, 2023, the Company adopted this standard using a modified retrospective approach, which requires a cumulative-effect adjustment to the opening balance of retained earnings to be recognized on the date of adoption and, accordingly, recorded a net increase of $0.1 million to accumulated deficit as of the beginning of fiscal 2024. In connection with the adoption of Topic 326, the Company made an accounting policy election to not measure an allowance for credit losses for accrued interest receivable.

Recently issued accounting pronouncement not yet adopted

In December 2023, the FASB issued ASU No. 2023-09 "Income Taxes (Topic 740)". The amendments in this ASU require that public business entities on an annual basis (1) disclose specific categories in the rate reconciliation and (2) provide additional information for reconciling items that meet a quantitative threshold. The amendments in this update are effective for annual periods beginning after December 15, 2024. The standard is not expected to have a material impact to the Company's condensed consolidated financial statements.

In November 2023, the FASB issued ASU No. 2023-08 "Segment Reporting (Topic 280)". The amendments in this ASU improve reportable segment disclosure requirements, primarily through enhanced disclosures about significant segment expenses. The amendments in this update are effective for fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. The standard is not expected to have a material impact to the Company's condensed consolidated financial statements.

The Company has evaluated other recently issued accounting pronouncements and has concluded that the impact of recently issued standards that are not yet effective will not have a material impact on the Company’s financial position or results of operations upon adoption.

3. Fair value measurement

The Company assesses the fair value of financial instruments based on the provisions of ASC 820, Fair Value Measurements. ASC 820 defines fair value as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. ASC 820 also establishes a fair value hierarchy which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The standard describes three levels of inputs that may be used to measure fair value:

Level 1—Quoted prices in active markets for identical assets or liabilities.

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Level 2—Observable inputs other than Level 1 prices such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

In determining fair value, the Company utilizes valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible as well as considering counterparty credit risk in its assessment of fair value.

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of June 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	239,142	$	—	$	—	$	239,142
Short-term investments:

U.S. government treasury bills	50,304		—		(29)		50,276
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	293,158	$	—	$	(29)	$	293,129

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of September 30, 2023:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	286,470	$	—	$	—	$	286,470
Short-term investments:
Corporate bonds	14,918		—		(29)		14,889
U.S. government treasury bills	35,111		—		(57)		35,054
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	340,210	$	—	$	(86)	$	340,124

As of June 30, 2024, financial assets and liabilities measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	196,413	$	—	$	—	$	196,413

U.S. government treasury bills	50,276		—		—		50,276
Non-current assets - investment in equity securities	—		—		3,711		3,711
Total	$	246,689	$	—	$	3,711	$	250,400

Total financial liabilities	$	—	$	—	$	—	$	—

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As of September 30, 2023, financial assets and liabilities measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	245,654	$	—	$	—	$	245,654
Corporate bonds	—		14,889		—		14,889
U.S. government treasury bills	35,054		—		—		35,054
Non-current assets - investment in equity securities	—		—		3,711		3,711
Total financial assets	$	280,708	$	14,889	$	3,711	$	299,308

Total financial liabilities	$	—	$	—	$	—	$	—

Contractual maturities of all the investments, as of June 30, 2024, were less than 12 months. The Company does not intend to sell the money market funds and short-term investments and it is not more likely than not that the Company will be required to sell the investments before recovery of their amortized cost basis. The Company's short-term investments have been in a continuous unrealized loss position for less than 12 months. Accrued interest receivable balances included in the prepaid expenses and other current assets within the condensed consolidated balance sheets were $1.0 million and $1.2 million as of June 30, 2024 and September 30, 2023, respectively. As of June 30, 2024, the gross unrealized losses on short-term investments are related to market interest rate changes and not attributable to credit.

During 2021 and as amended in 2022, the Company entered into convertible promissory note agreements with a privately held company (“Borrower”) pursuant to which the Company agreed to loan to the Borrower $3.5 million in a series of loan installments, evidenced by a convertible promissory note having a maturity date of May 1, 2023 (“Convertible Note”). The Convertible Note included an option to convert the Convertible Note into the Borrower’s equity at the Borrower’s next round of equity financing, and accrued interest at a rate of 4% per annum. In April 2023, the Company exercised the option and the Borrower issued to the Company ordinary shares which represent a 15% equity interest. As of June 30, 2024, the Company’s equity investments were categorized as Level 3 within the fair value hierarchy.

The equity investment held by the Company is a VIE, but the Company is not the primary beneficiary. The Company does not have the power to direct the activities that most significantly impact the economic performance of the investee. The Company’s maximum exposure to loss from this VIE consist of an equity investment of $3.7 million. Equity investments held by the Company lack readily determinable fair values and therefore the securities are measured at cost minus impairment, if any, plus or minus changes resulting from observable price changes in orderly transactions for the identical or similar equity securities of the same issuer. The Company reviews the carrying value of its equity investments for impairment whenever events or changes in business circumstances indicate the carrying amount of such asset may not be fully recoverable. Impairments, if any, are based on the excess of the carrying amount over the recoverable amount of the asset. There were no such impairments during the three months ended June 30, 2024 and June 30, 2023.

As of June 30, 2024 and September 30, 2023, there were no financial liabilities categorized as level 3 within the fair value hierarchy. There were no transfers between Level 1, Level 2 and Level 3 in the periods presented.

The following table provides a reconciliation of beginning and ending balances of the Level 3 financial assets during the three months ended June 30, 2024:


(in thousands)	Equity investments		Total
Balance as of September 30, 2023	$	3,711	$	3,711
Change in fair value	—		—
Additions during the year	—		—
Balance as of June 30, 2024	$	3,711	$	3,711

4. Balance sheet components

Inventories consist of the following:

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(in thousands)	June 30, 2024		September 30, 2023
Raw materials	$	22,000	$	27,024
Work-in-process	2,213		1,113
Finished goods	4,271		3,926
	$	28,484	$	32,063

There is no consigned inventory balance as of June 30, 2024 and September 30, 2023.

Property and Equipment, net consists of the following:


(in thousands)	June 30, 2024		September 30, 2023
Laboratory equipment	$	99,354	$	104,508
Furniture, fixtures and other equipment	3,279		3,484
Vehicles	211		85
Computer equipment	3,555		3,103
Computer software	9,077		5,507
Leasehold improvements	58,197		57,271
Construction in progress	3,296		8,528
	$	176,969	$	182,486
Less: Accumulated depreciation	(70,630)		(50,656)
	$	106,339	$	131,830

As of June 30, 2024, the construction in progress mainly represents equipment costs and software development costs. For the three and nine months ended June 30, 2024, the total depreciation expense was $7.0 million and $20.9 million, respectively. For the three and nine months ended June 30, 2023 the total depreciation expense was $6.9 million and $16.8 million, respectively. The Company recorded impairment charges of $9.1 million for the three and nine months ended June 30, 2024. See note 13.

The other current liabilities consist of the following:


(in thousands)	June 30, 2024		September 30, 2023
Income and other taxes payable	$	2,343	$	4,374
Contract liabilities	2,940		2,999
Other current liabilities	796		430

	$	6,079	$	7,803

5. Goodwill and intangible assets

There were no changes to the carrying value of goodwill during the nine months ended June 30, 2024.

The goodwill balance is presented below:


(in thousands)	June 30, 2024		September 30, 2023
Balance at beginning of period/year	$	85,811	$	85,811
Balance at end of period/year	$	85,811	$	85,811

The intangible assets balances are presented below:

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	June 30, 2024
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Impairment		Accumulated amortization		Net book value
Developed Technology	17	$	50,020	$	(25,198)	$	(10,081)	$	14,741
Customer Relationships	—	15,210		(10,541)		(4,669)		—
Tradenames & Trademarks	—	900		(125)		(775)		—
Total finite-lived intangible assets		$	66,130	$	(35,864)	$	(15,525)	$	14,741


	September 30, 2023
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Accumulated amortization		Net book value
Developed Technology	15	$	50,020	$	(7,636)	$	42,384
Customer Relationships	11	15,210		(3,461)		11,749
Tradenames & Trademarks	3	$	900	$	(550)	$	350
Total finite-lived intangible assets		$	66,130	$	(11,647)	$	54,483

Total amortization expense related to finite-lived intangible assets was $1.3 million for the three months ended June 30, 2024 and $1.3 million for the three months ended June 30, 2023. Total amortization expense related to finite-lived intangible assets was $3.9 million for the nine months ended June 30, 2024 and $3.9 million for the nine months ended June 30, 2023. The Company recorded impairment charges of $35.9 million for the three and nine months ended June 30, 2024. See note 13.

6. Commitments and contingencies

Legal proceedings

The Company may be subject to litigation, claims and disputes in the ordinary course of business. There is an inherent risk in any litigation or dispute and no assurance can be given as to the outcome of any claims.

Securities Class Action

On December 12, 2022, a putative securities class action lawsuit captioned Peters v. Twist Bioscience Corporation, et al., Case No. 22-cv-08168 (N.D. Cal.) (“Securities Class Action”) was filed in federal court in the Northern District of California (“Court”) against the Company, its Chief Executive Officer, and its Chief Financial Officer (the “Defendants”) alleging violations of federal securities laws. The Securities Class Action’s claims are based in large part on allegations made in a report issued on November 15, 2022 by Scorpion Capital (“Scorpion Report”) concerning, among other things, the Company’s DNA chip technology and accounting practices. The initial complaint filed in the Securities Class Action alleges that various statements that the defendants made between December 13, 2019 and November 14, 2022 were materially false and misleading in light of the allegations in the Scorpion Report. The plaintiff who initiated the lawsuit sought to represent a class of shareholders who acquired shares of the Company’s common stock between December 13, 2019 and November 14, 2022 and sought damages as well as certain other costs. On July 28, 2023, the Court appointed a new plaintiff, not the original plaintiff who filed the case, as lead plaintiff in the case and appointed a new law firm as lead counsel. On October 11, 2023, the lead plaintiff filed an amended complaint. The amended complaint is purportedly brought on behalf of all persons other than the Defendants who acquired the Company’s securities between December 20, 2018 and November 15, 2022. The amended complaint alleges that certain statements regarding, among other things, the Company’s DNA products and accounting practices were false and misleading.

This case remains in the preliminary stage. Given the inherent uncertainty of litigation and the legal standards that must be met, including class certification and success on the merits, the Company cannot express an opinion on the likelihood of an unfavorable outcome or on the amount or range of any potential loss. The Company and the other defendants intend to vigorously defend themselves against the claims asserted against them and filed a motion to dismiss the amended complaint on December 6, 2023, which the Court has taken under submission.

Derivative Action

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On September 25, 2023, a shareholder derivative suit captioned Shumacher vs. Leproust et al., No. 1:23-cv-01048-UNA, was filed in the United States District Court for the District of Delaware against directors of the Company and an employee (the “Derivative Action”). The suit is based on substantially the same allegations in the Securities Class Action and seeks to recover, on behalf of the Company, damages to the Company arising from, among other things, the Securities Class Action. On November 13, 2023, the parties to the Derivative Action entered into a stipulation staying the Derivative Action pending resolution of the anticipated motion to dismiss the defendants have filed in the Securities Class Action.

Indemnifications

In the ordinary course of business, the Company enters into agreements that may include indemnification provisions. Pursuant to such agreements, the Company may indemnify, hold harmless and defend the indemnified parties for losses suffered or incurred by the indemnified party. Some of the provisions will limit losses to those arising from third-party actions. In some cases, the indemnification will continue after the termination of the agreement. The maximum potential amount of future payments the Company could be required to make under these provisions is not determinable. To date, the Company has not incurred material costs to defend lawsuits or settle claims related to these indemnification provisions. From time to time, the Company has entered into indemnification agreements with its directors and officers that requires it to indemnify its directors and officers against liabilities that may arise by reason of their status or service as directors or officers to the fullest extent permitted by law. The Company also has directors’ and officers’ insurance.

Leases

The Company leases certain of its facilities under non-cancellable operating leases expiring at various dates through 2044. The Company is also responsible for utilities, maintenance, insurance, and property taxes under these leases. The Company's lease payments consist primarily of fixed rental payments for the right to use the underlying leased assets over the lease terms, as well as payments for common-area-maintenance and administrative services. The Company often receives customary incentives from its landlords, such as reimbursements for tenant improvements and rent abatement periods, which effectively reduce the total lease payments owed for these leases. Leases are classified as operating or financing at commencement. The Company does not have any material financing leases.

Certain leases include options to renew or terminate at the Company’s discretion. The lease terms include periods covered by these options if it is reasonably certain the Company will renew or not terminate. The Company’s lease agreements do not contain any material residual value guarantees or restrictive covenants.

Supplemental balance sheet information related to the Company’s operating leases as of June 30, 2024 is as follows:


(in thousands)	June 30, 2024
Assets:
Operating lease right-of-use asset	$	61,277
Current liabilities:
Current portion of operating lease liabilities	$	14,555
Noncurrent liabilities:
Operating lease liabilities, net of current portion	$	72,625

Future minimum lease payments under all non-cancelable operating leases that have commenced as of June 30, 2024 are as follows:

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(in thousands)	Operating leases
Years ending September 30:
Remainder of 2024	$	3,636
2025	14,814
2026	13,885
2027	8,371
2028	8,471
Thereafter	88,014
Total minimum lease payments	$	137,191
Less: imputed interest	(50,011)

Total operating lease liabilities	$	87,180
Less: current portion	(14,555)
Operating lease liabilities, net of current portion	$	72,625

The statement of cash flows for the nine months ended June 30, 2024 include changes in right-of-use assets and operating lease liabilities of $7.5 million and $6.9 million, respectively. For the nine months ended June 30, 2023, changes in right-of-use assets and operating lease liabilities were $2.9 million and $1.9 million, respectively.

During the three and nine months ended June 30, 2024, operating lease expense was $3.8 million and $11.8 million, respectively. Cash payments for amounts included in the measurement of operating lease liabilities were $3.7 million and $11.1 million for the three and nine months ended June 30, 2024, respectively. During the three and nine months ended June 30, 2023, operating lease expense was $3.9 million and $12.2 million, respectively. Cash payments for amounts included in the measurement of operating lease liabilities were $3.6 million and $11.1 million for the three and nine months ended June 30, 2023, respectively. As of June 30, 2024, the weighted-average remaining lease term was 15.2 years and the weighted-average discount rate was 6.5%.

7. Related party transactions

During the three months ended June 30, 2024 and 2023, the Company purchased raw materials from a related party in the amount of $1.7 million and $1.4 million, respectively. During the nine months ended June 30, 2024 and 2023, the purchases of raw materials from a related party were $4.5 million and $5.0 million, respectively. During the three and nine months ended June 30, 2024, the Company had revenues from the related party in the amount of $4.1 million and $9.7 million, respectively. During the three and nine months ended June 30, 2023, the Company generated revenues from the related party totaling $0.9 million and $3.6 million, respectively. As of June 30, 2024, payable balances and receivable balances with the related party were $0.2 million and $0.8 million, respectively. Receivable balances with the related party were $1.7 million as of September 30, 2023. Payable balances with the related parties were immaterial as of September 30, 2023.

8. Income taxes

In determining quarterly provisions for income taxes, the Company uses the annual estimated effective tax rate applied to the actual year-to-date profit or loss, adjusted for discrete items arising in that quarter. For the three and nine months ended June 30, 2024, the Company recorded provisions for income taxes of $0.2 million and $0.7 million, respectively. For the three and nine months ended June 30, 2023, the Company recorded provisions for income taxes of $0.6 million and $1.4 million, respectively.

9. Common stock

As of June 30, 2024, the Company had reserved sufficient shares of common stock, with a par value of $0.00001 per share, for issuance upon exercise of outstanding stock options. Each share of common stock is entitled to one vote. The holders of shares of common stock are also entitled to receive dividends whenever funds are legally available and when declared by the board of directors.

10. Stock-based compensation

The Company grants stock-based awards, consisting of stock options and restricted stock, to its employees, certain non-employee consultants and certain members of its board of directors. The Company measures stock-based compensation

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expense for restricted stock and stock options granted to its employees and directors on the date of grant and recognizes the corresponding compensation expense of those awards over the requisite service period, which is generally the vesting period of the respective award. The Company measures stock-based compensation expense for restricted stock and stock options granted to non-employee consultants on the date of grant and recognizes the corresponding compensation expense of those awards over the period in which the related services are received. The Company adjusts for actual forfeitures as they occur.

2018 Equity Incentive Plan

On September 26, 2018, the board of directors adopted the 2018 Equity Incentive Plan (the “2018 Plan”) as a successor to the 2013 Stock Plan (the “2013 Plan”). Any shares subject to outstanding awards under the 2013 Plan that are canceled or repurchased subsequent to the 2018 Plan’s effective date are returned to the pool of shares reserved for issuance under the 2018 Plan. Awards granted under the 2018 Plan may be non-statutory stock options, stock appreciation rights, restricted stock, restricted stock units, performance shares, and performance units.

Inducement Equity Incentive Plan

On August 22, 2023, the board of directors adopted an inducement equity incentive plan (the “Inducement Plan”). The maximum aggregate number of shares that may be issued under the Inducement Plan is 700,000 of the Company's common stock. The Inducement Plan permits the grant of non-statutory stock options, restricted stock, restricted stock units, stock appreciation rights, performance units and performance shares. The shares issuable under the Inducement Plan are registered pursuant to a registration statement on Form S-8 filed with the Securities and Exchange Commission on August 25, 2023.

Restricted Stock Units

Restricted stock consists of restricted stock unit awards (“RSUs”) which have been granted to employees and non-employee directors. The value of an RSU award is based on the Company’s stock price on the date of grant. Employee grants generally vest over four years and non-employee director grants generally vest over one year. Forfeitures of RSUs are recognized as they occur. The shares underlying the RSU awards are not issued until the RSUs vest. Upon vesting, each RSU converts into one share of the Company’s common stock.

Activity with respect to the Company’s restricted stock units during the nine months ended June 30, 2024 was as follows:


(in thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2023	1,620	$	40.73
Granted	1,414	26.10
Vested/Issued	(604)	39.61
Forfeited	(262)	40.08
Nonvested shares at June 30, 2024	2,168	$	31.62

As of June 30, 2024, there was $62.3 million of total unrecognized compensation cost related to these awards that is expected to be recognized over a weighted average period of 2.6 years. The total grant date fair value of RSUs awarded during the nine months ended June 30, 2024 was $36.9 million.

Performance Stock Units

Performance stock unit awards (“PSUs”) granted to Company executives will vest upon achievement of multiple year revenue, gross profit and cash balance metrics as determined by the board of directors, and to certain non-employee consultants will vest upon achievement of operational milestones. Stock compensation expense for PSUs is recorded over the vesting period based on the grant date fair value of the awards and probability of the achievement of specified performance targets. The grant date fair value is equal to the closing share price of the Company’s common stock on the date of grant. For Company executives, PSUs generally vest over a two to three-year service period following the grant date, provided that the recipient is a Company employee at the time of vesting and the performance targets applicable to each award are achieved. For non-employees, PSUs generally vest over a one to three-year service period following the grant date, provided that the performance targets applicable to each award are achieved. The percentage of PSUs that vest will depend on the achievement of specified performance targets at the end of the performance period and can range from 0% to 150% of the number of units granted. Any PSUs that are unvested at the end of the performance period are forfeited. Forfeitures of PSUs are recognized as they occur.

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Activity under the PSUs during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2023	932	$	36.82
Granted	617	18.71
Vested/Issued	(84)	80.67
Forfeited	(81)	29.28
Nonvested shares at June 30, 2024	1,384	$	26.52

As of June 30, 2024, the unrecognized compensation costs related to these awards was $18.1 million based on the maximum achievement of the performance targets. The Company expects to recognize those costs over a weighted average period of 1.3 years. The total grant date fair value of PSUs awarded during the nine months ended June 30, 2024 was $11.5 million.

Options

Options are generally granted to employees and were granted to non-employee directors until FY 2020. Stock options entitle the holder to purchase, at the end of the vesting term, a specified number of shares of Company common stock at an exercise price per share equal to the closing market price of the common stock on the date of grant. Stock options have a contractual life from the date of the grant and a vesting schedule as established by the board of directors. The maximum term of stock options granted under the 2018 Plan is 10 years and the awards generally vest over a four-year period. Forfeitures of options are recognized as they occur. The fair value of each service based stock option grant is estimated on the date of grant using the Black-Scholes option-pricing model. The Company has not granted any stock options during the three and nine months ended June 30, 2024 or 2023.

Options activity during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2023	2,119	$	24.18	5.25	$	6,715
Forfeited	(115)	38.64		—	—
Exercised	(261)	19.85		—	5,123

Outstanding at June 30, 2024	1,743	$23.88		4.41	$	47,265
Nonvested at June 30, 2024	6	106.25		7.03	—
Exercisable at June 30, 2024	1,737	$	23.61	4.40	$	47,265

As of June 30, 2024, the unrecognized compensation costs related to these awards was $0.3 million. The Company expects to recognize those costs over a weighted average period of 1.1 years. The Company did not grant any options during the nine months ended June 30, 2024.

Performance Stock Options

On September 1, 2020, the board of directors approved the implementation of a revised annual equity award program for executive officers, senior level employees and consultants to be granted as performance-based stock options ("PSOs") under the 2018 Plan. The PSOs issued to executive officers and senior level employees vested in prior years. The number of PSOs ultimately earned under the awards to a consultant is calculated based on the achievement of certain operational milestones. The maximum term of performance stock options granted under the 2018 Plan is 10 years for both employees and non-employees. The awards generally vest over a two-year period for executive officers and senior level employees. Awards to non-employees generally vest over a five-year period.

The provisions of the PSOs are considered a performance condition, and the effects of that performance condition are not reflected in the grant date fair value of the awards. The Company used the Black-Scholes method to calculate the fair value at the grant date without regard to the vesting condition and will recognize compensation cost for the options that are expected to vest. Forfeitures of PSOs are recognized as they occur. The Company reassesses the probability of the performance condition at each reporting period and adjusts the compensation cost based on the probability assessment. As

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of June 30, 2024, the Company determined that 30,000 shares are expected to vest based on the probability of the performance condition that will be achieved under this equity award program.

Activity under the PSOs during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2023	289	$	60.82	7.37	$	—
Nonvested at September 30, 2023	30	$	31.29	8.57	$	—
Exercisable at September 30, 2023	259	64.24		7.23	—
Forfeited	(12)	$	67.85	—	$	—
Exercisable at June 30, 2024	247	$	64.07	6.49	$	810
Nonvested at June 30, 2024	30	31.29		7.82	540
Outstanding at June 30, 2024	277	$	60.53	6.63	$	1,349

As of June 30, 2024, the unrecognized compensation costs related to these awards was $0.2 million. The Company expects to recognize those costs over a weighted average period of 0.8 years.

Total stock-based compensation expense recognized was as follows:


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Cost of revenues	$	1,033	$	1,286	$	3,006	$	3,898
Research and development	2,400		3,329		8,614		10,837
Selling, general and administrative	10,301		5,983		26,958		3,796
Total stock-based compensation	$	13,734	$	10,598	$	38,578	$	18,531

During the three and nine months ended June 30, 2023, stock-based compensation decreased primarily as a result of departing employee share forfeitures, and a stock-based credit related to a business combination due to non-achievement of a performance condition. An immaterial amount of stock-based compensation was capitalized to inventories attributable to employees who support the manufacturing of the Company's products for the three and nine months ended June 30, 2024 and 2023. An immaterial amount of stock-based compensation was capitalized to property and equipment related to capitalized software development costs for the three and nine months ended June 30, 2024. The stock-based compensation of $0.1 million and $0.5 million was capitalized to property and equipment related to the capitalized software development costs for the three and nine months ended June 30, 2023.

2018 Employee Stock Purchase Plan

On September 26, 2018, the board of directors adopted the 2018 Employee Stock Purchase Plan (the "2018 ESPP"). The number of shares reserved for issuance under the 2018 ESPP upon approval was 275,225 shares of the Company’s common stock, and it increases automatically on the first day of each fiscal year, following the fiscal year in which the 2018 ESPP became effective, by a number equal to the least of 249,470 shares, 1% of the shares of common stock outstanding at that time, or such number of shares determined by the Company’s board of directors. The number of shares reserved for issuance at June 30, 2024 was as follows:


(In thousands)						Shares available
Outstanding at September 30, 2023						539
Additional shares authorized						249
Shares issued during the period						(124)
Outstanding at June 30, 2024						664

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Subject to any plan limitations, the 2018 ESPP allows eligible service providers (through qualified and non-qualified offerings) to contribute, normally through payroll deductions, up to 15% of their earnings for the purchase of the Company’s common stock at a discounted price per share. The offering periods begin in February and August of each year, except the initial offering period which commenced with the initial public offering in October 2018 and ended on August 20, 2019.

Unless otherwise determined by the board of directors, the Company’s common stock will be purchased for the accounts of employees participating in the 2018 ESPP at a price per share that is the lesser of 85% of the fair market value of the Company’s common stock on the first trading day of the offering period or 85% of the fair market value of the Company’s common stock on the last trading day of the offering period. During the three and nine months ended June 30, 2024 ESPP expenses of $0.5 million and $1.3 million, respectively was recognized. During the three and nine months ended June 30, 2023, activity under the 2018 ESPP was immaterial.

401(k) Savings Plan

During 2018, the Company adopted a 401(k) savings plan for the benefit of its employees. In January 2022, the Company modified its plan to include an employer matching contribution. The Company is required to make matching contributions to the 401(k) plan equal to 50% of the first 6% of wages deferred by each participating employee. The Company incurred expenses for employer matching contributions of $0.7 million and $2.0 million for the three and nine months ended June 30, 2024, respectively. The Company incurred expenses for employer matching contributions of $0.7 million and $2.2 million for the three and nine months ended June 30, 2023, respectively.

AbX Biologics, Inc. (Abveris) Acquisition

At September 30, 2022, management determined that the achievement of the performance condition relating to the equity awards granted in connection with the Abveris acquisition awards was probable, and cumulative stock-based compensation expense of $9.9 million was recognized during the year ended September 30, 2022. At December 31, 2022, management determined that the performance condition was not achieved, and therefore the cumulative stock-based compensation expense recognized to date was reversed, resulting in a reduction of stock compensation expense of $9.9 million in the three months ended December 31, 2022.

11. Net loss per share attributable to common stockholders

The following table sets forth the computation of the Company’s basic and diluted net loss per share attributable to common stockholders:


	Three months ended June 30,				Nine months ended June 30,
(in thousands, except per share data)	2024		2023		2024		2023
Numerator:
Net loss attributable to common stockholders	$	(85,571)	$	(57,395)	$	(174,071)	$	(158,375)
Denominator:
Weighted average shares used in computing net loss per share, basic and diluted	58,145		57,041		57,806		56,753
Net loss per share attributable to common stockholders, basic and diluted	$	(1.47)	$	(1.01)	$	(3.01)	$	(2.79)

The potentially dilutive common shares that were excluded from the calculation of diluted net loss per share because their effect would have been antidilutive for the periods presented are as follows:

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	Three and nine months ended
	June 30,
(in thousands)	2024	2023
Shares subject to options (including performance options) to purchase common stock	2,020	2,546

Unvested restricted stock units and performance stock units	3,552	2,371
Shares subject to employee stock purchase plan	86	78
Total	5,658	4,995

12. Geographic, product and industry information

The table below sets forth revenues by geographic region, based on ship-to destinations. Americas consists of the United States of America, Canada, Mexico and South America; EMEA consists of Europe, the Middle East, and Africa; and APAC consists of Japan, China, South Korea, India, Singapore, Malaysia, Australia, New Zealand, Thailand and Taiwan.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Americas	$	51,389	$	39,016	$	141,221	$	107,586
EMEA	23,581		19,069		67,064		54,179
APAC	6,494		5,655		19,979		16,398
Total	$	81,464	$	63,740	$	228,264	$	178,163

The table below sets forth revenues by products.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Synthetic genes	$	24,948	$	19,302	$	67,031	$	53,488
Oligo pools	4,166		3,735		12,295		10,749
DNA libraries	3,848		2,880		10,318		7,542
Antibody discovery	5,102		4,580		15,029		19,785
NGS tools	43,400		33,243		123,591		86,599
Total	$	81,464	$	63,740	$	228,264	$	178,163

The table below sets forth revenues by industry.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Industrial chemicals/materials	$	23,188	$	16,801	$	59,730	$	44,785
Academic research	14,892		12,421		42,387		33,556
Healthcare	42,823		33,988		124,637		97,764
Food/agricultural	561		530		1,510		2,058
Total	$	81,464	$	63,740	$	228,264	$	178,163

13. Impairment of long-lived assets

During the three months ended June 30, 2024, the Company identified an impairment indicator with respect to an asset group associated with our antibody discovery services product line (“Biopharma asset group”) due to lower than forecasted revenues. Therefore, the Company performed a recoverability test of long-lived assets by comparing the net book value of the long-lived asset group, to the future undiscounted net cash flows attributable to such assets. The Company concluded

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that the carrying value of the asset group was not recoverable as it exceeded the future undiscounted cash flows the assets are expected to generate from the use and eventual disposition.

To measure, allocate and recognize the impairment loss, the Company estimated the fair value of the Biopharma asset group by applying a discounted cash flow method. Calculating the fair value of an asset group involves significant estimates and assumptions. These estimates and assumptions include, among others, the level and timing of revenues, operating expenses, taxes, and working capital, capital asset requirements over the remaining life of the primary asset in the asset group, and discount rates, the Company believes to be consistent with the inherent risks associated with the asset group, which was approximately 14%. Changes in these factors and assumptions used can materially affect the amount of impairment loss recognized in the period the asset group was considered impaired.

The implied allocated impairment loss to any individual asset within the long-lived asset group shall not reduce the carrying amount of that asset below its fair value. The Company estimated the fair value of the developed technology intangible asset and the customer relationships intangible assets using an excess earnings model (income approach). The Company estimated the fair value of the trade name intangible asset using a relief from royalty approach. Key assumptions include the level and timing of expected future revenue, conditions and demands specific to each intangible asset over its remaining useful life. The fair value of these intangible assets is primarily affected by the projected revenues, gross margins, operating expenses, and the anticipated timing of the projected income associated with each intangible asset coupled with the discount rates used to derive their estimated present values. The Company determined the fair value of property and equipment based on a market participant perspective. For lease right-of-use assets, the Company determined the estimated fair value of the assets by comparing the discounted contractual rent payments to estimated market rent using an acceptable valuation methodology. Significant assumptions used to determine the fair values of certain lease right-of-use assets included the current market rent and discount rate.

These fair value measurements were based on significant inputs not observable in the market and thus represent a Level 3 measurement. The Company believes the level and timing of expected future cash flows appropriately reflects market participant assumptions.

As a result of allocating the impairment, the Company recorded the following impairment charges, which are included in “Impairment of long-lived assets” on our condensed consolidated statements of operations and comprehensive loss for the three and nine months ended June 30, 2024:


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Property and equipment	$	9,066	$	3,620	$	9,066	$	3,620
Finite-lived intangible assets	35,864		—		35,864		—
Total	$	44,930	$	3,620	$	44,930	$	3,620

During the three and nine months ended June 30, 2023, the Company recognized impairment of property and equipment. See note 14.

14. 2023 Restructuring and other costs

On May 3, 2023, the Company’s Board of Directors approved a strategic restructuring plan to reduce costs, build a leaner organization and increase operating efficiencies. The restructuring plan included a reduction in force which affected approximately 270 employees worldwide, representing approximately 25% of the Company’s total workforce. The majority of these employees separated from the Company by September 30, 2023. The reduction in force is subject to local regulatory requirements. Furthermore, as part of the plan the Company removed the duplication of synthetic biology production across its South San Francisco, California and Wilsonville, Oregon facilities. The plan was implemented beginning in May 2023 and was substantially completed by the end of fiscal year 2023.

Total restructuring and other costs of $12.7 million was incurred by the Company during the three and nine months ended June 30, 2023 and included employee severance and related benefit costs of $8.6 million, restructuring and non-restructuring related impairment of property and equipment of $3.6 million, and other costs associated with restructuring of $0.4 million.

* * * * *

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Item 2. Management’s discussion and analysis of financial condition and results of operations

You should read the following discussion and analysis of our financial condition and results of operations together with the unaudited condensed consolidated financial statements and related notes that are included elsewhere in this Quarterly Report on Form 10-Q and our Annual Report on Form 10-K for the fiscal year ended September 30, 2023 filed with the U.S. Securities and Exchange Commission, or the SEC, on November 21, 2023, or our Annual Report on Form 10-K. This discussion contains forward-looking statements based upon current plans, expectations and beliefs that involve risks and uncertainties. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of various factors, including, but not limited to, those discussed in the section entitled “Risk Factors” and elsewhere in this Quarterly Report on Form 10-Q. In preparing this MD&A, we presume that readers have access to and have read the MD&A in our Annual Report on Form 10-K, pursuant to Instruction 2 to paragraph (b) of Item 303 of Regulation S-K.

Overview

We are an innovative synthetic biology and genomics company that has developed a scalable DNA synthesis platform to industrialize the engineering of biology. The core of our platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. We have miniaturized traditional chemical DNA synthesis reactions to write over one million short pieces of DNA on each silicon chip, approximately the size of a large mobile phone. We have combined this technology with proprietary software, scalable commercial infrastructure, and an e-commerce platform to create an integrated technology platform that enables us to achieve high levels of quality, precision, automation, and manufacturing throughput at a significantly lower cost than our competitors. We are leveraging our unique technology to manufacture a broad range of synthetic DNA based products, including synthetic genes, tools for next-generation sample preparation, and antibody libraries for drug discovery and development.

Additionally, we believe our platform will enable new value-added opportunities, such as discovery partnerships for biologic drugs, and will enable new applications for synthetic DNA, such as digital data storage. We sell our synthetic DNA and synthetic DNA-based products to a customer base of approximately 3,450 customers annually across a broad range of industries.

We launched the first application of our platform, synthetic genes and oligo pools, in April 2016 to disrupt the gene synthesis market and make legacy DNA synthesis methods obsolete.

We have grown rapidly and generated revenues of $81.5 million and $63.7 million in the three months ended June 30, 2024 and 2023, respectively, while incurring net losses of $85.6 million and $57.4 million for the three months ended June 30, 2024 and 2023, respectively. Since our inception, we have incurred significant operating losses and have accumulated net deficit of $1,207.3 million. Our ability to generate product revenue sufficient to achieve profitability will depend heavily on the success of our existing products and the development and commercialization of additional products in the synthetic biology, biologic drug and data storage industries, including our Express Genes which we launched in the fall of 2023, as well as leveraging our investment in our manufacturing facility in Wilsonville, Oregon.

For the three months ended June 30, 2024 and 2023, the number of customers who purchased products from us were approximately 2,300 and 2,200 customers, respectively.

Highlights from three months ended June 30, 2024 compared with three months ended June 30, 2023 include:

•Revenue growth of 28% to $81.5 million from $63.7 million, primarily due to order growth in NGS tools and synthetic genes;

•Number of our genes shipped increased to 212,000 from 171,000;

•Gross margin increased to 43.3% from 34.4%;

In addition, for the nine months ended June 30, 2024, the net cash used in operating activities decreased to $48.8 million from $121.8 million for the nine months ended June 30, 2023.

We have built a scalable commercial platform that enables us to serve a diverse customer base in a variety of industries including healthcare, industrial chemicals/materials, academic research, food/agriculture and data storage. To address this diverse customer base, we have employed a multichannel strategy comprised of a direct sales force targeting synthetic DNA customers, international distributors, and an e-commerce platform. Launched in fiscal 2018, our e-commerce platform allows customers to design, validate and place on-demand orders of customized DNA online. This is a key

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component of our strategy to address and support our diverse and growing customer base, as well as support commercial productivity, enhance the customer experience, and promote loyalty.

Financial overview

The following table summarizes certain selected historical financial results:


	Three months ended				Nine months ended
	June 30,				June 30,
(in thousands)	2024		2023		2024		2023
Revenues	$	81,464	$	63,740	$	228,264	$	178,163
Loss from operations	(88,922)		(60,781)		(184,788)		(167,047)
Net loss attributable to common stockholders	(85,571)		(57,395)		(174,071)		(158,375)

Revenues

We generate revenue from sales of synthetic genes, oligo pools, NGS tools, DNA libraries and antibody discovery services. Our ability to increase our revenues will depend on our ability to further penetrate the domestic and international markets, generate sales through our direct sales force, distributors and over time from our e-commerce digital platform and launch new products.

Revenues by geography

We have one reportable segment from the manufacturing of synthetic DNA products. The following table shows our revenues by geography, based on our customers’ shipping addresses. Americas consists of United States, Canada, Mexico and South America; EMEA consists of Europe, Middle East and Africa; and APAC consists of Japan, China, South Korea, India, Singapore, Malaysia, Australia, New Zealand, Thailand and Taiwan.


	Three months ended June 30,								Nine months ended June 30,
(in thousands, except percentages)	2024		%		2023		%		2024		%		2023		%
Americas	$	51,389	61	%	$	39,016	58	%	$	141,221	61	%	$	107,586	60	%
EMEA	23,581		30	%	19,069		31	%	67,064		30	%	54,179		31	%
APAC	6,494		9	%	5,655		11	%	19,979		9	%	16,398		9	%
Total revenues	$	81,464	100	%	$	63,740	100	%	$	228,264	100	%	$	178,163	100	%

Revenues by product

The table below sets forth revenues by product:


	Three months ended June 30,								Nine months ended June 30,
(in thousands, except percentages)	2024		%		2023		%		2024		%		2023		%
Synthetic genes	$	24,948	29	%	$	19,302	30	%	$	67,031	28	%	$	53,488	30	%
Oligo pools	4,166		6	%	3,735		5	%	12,295		6	%	10,749		6	%
DNA libraries	3,848		5	%	2,880		5	%	10,318		4	%	7,542		4	%
Antibody discovery	5,102		6	%	4,580		12	%	15,029		7	%	19,785		13	%
NGS tools	43,400		54	%	33,243		48	%	123,591		55	%	86,599		47	%
Total revenues	$	81,464	100	%	$	63,740	100	%	$	228,264	100	%	$	178,163	100	%

Revenues by industry

The table below sets forth revenues by industry:

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	Three months ended June 30,								Nine months ended June 30,
(in thousands, except percentages)	2024		%		2023		%		2024		%		2023		%
Industrial chemicals/materials	$	23,188	27	%	$	16,801	24	%	$	59,730	25	%	$	44,785	24	%
Academic research	14,892		18	%	12,421		19	%	42,387		18	%	33,556		19	%
Healthcare	42,823		54	%	33,988		56	%	124,637		56	%	97,764		56	%
Food/agriculture	561		1	%	530		1	%	1,510		1	%	2,058		1	%
Total revenues	$	81,464	100	%	$	63,740	100	%	$	228,264	100	%	$	178,163	100	%

Product shipments including synthetic genes

Shipments of all products and number of genes shipped in the three months ended June 30, 2024, March 31, 2024, December 31, 2023, September 30, 2023, June 30, 2023, March 31, 2023, December 31, 2022, and September 30, 2022 were as follows:


	Three months ended
	June 30,	March 31,	December 31,	September 30,	June 30,	March 31,	December 31,	September 30,
(in thousands)	2024	2024	2023	2023	2023	2023	2022	2022
Number of genes shipped	212	193	171	177	171	152	134	146
Number of shipments	23	20	18	17	17	15	14(1)	20

(1) Previously reported number of shipments have been updated to conform to the current period presentation.

Comparison of the three months ended June 30, 2024 and 2023

Revenues


	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Revenues	$	81,464	$	63,740	$	17,724	28	%

Revenues increased 28% to $81.5 million for the three months ended June 30, 2024, as compared to $63.7 million for the three months ended June 30, 2023. The increase in revenue reflects growth in NGS tools revenue of $10.2 million and growth in synthetic genes revenue of $5.6 million, including Express Genes product line. The increase in revenue is primarily attributable to our top customers in the healthcare, industrial chemicals/materials, and academic research industries and an increase in customers. The number of our genes shipped in the three months ended June 30, 2024 increased to approximately 212,000 genes compared to approximately 171,000 genes in the three months ended June 30, 2023, an increase of 24%.

Cost of revenues


	Three months ended June 30,
(in thousands, except percentages)	2024			2023			Change			%
Cost of revenues	$	46,193		$	41,845		$	4,348		10	%
Gross profit	$	35,271		$	21,895		$	13,376		61	%
Gross margin	43.3		%	34.4		%	8.9		%

Cost of revenues increased 10% to $46.2 million for the three months ended June 30, 2024, as compared to $41.8 million for the three months ended June 30, 2023. The increase is primarily attributable to an increase in material costs of $5.1

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million due to higher sales volume. Gross margin increased 895 basis points to 43.3% for the three months ended June 30, 2024 as compared to 34.4% for the three months ended June 30, 2023 mainly due to increase in revenue and the fixed costs being spread over larger revenue base resulting in an increase in gross margin.

Research and development expenses


	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Research and development	$	22,469	$	24,528	$	(2,059)	(8)	%

Research and development expenses decreased 8% to $22.5 million for the three months ended June 30, 2024, as compared to $24.5 million for the three months ended June 30, 2023. The decrease is primarily due to decreases in personnel costs of $1.2 million, including stock-based compensation expense of $0.9 million due to the reduction of headcount related to the 2023 restructuring plan, outside services costs of $1.3 million and lab supplies costs of $0.4 million. These decreases are partially offset by a lack of grant reimbursement in 2024 where we received $0.8 million in 2023, which are netted against the research and development expenses.

Selling, general and administrative


	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Selling, general and administrative	$	56,794	$	46,057	$	10,737	23	%

Selling, general and administrative expenses increased 23% to $56.8 million for the three months ended June 30, 2024, as compared to $46.1 million for the three months ended June 30, 2023. The increase is primarily due to increases in personnel costs of $8.4 million, including stock-based compensation expense of $4.2 million, outside service costs $2.7 million, and IT services costs of $0.8 million. These increases are partially offset by the decrease in the Wilsonville manufacturing facility pre-commercialization costs of $1.1 million, which was completed when the Wilsonville manufacturing facility began shipping product in January 2023.

Restructuring and other costs


	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Restructuring and other costs	$	—	$	9,052	$	(9,052)	100	%

We recognized restructuring and other costs of $9.1 million resulting from the 2023 restructuring plan during the three months ended June 30, 2023.

Change in fair value of contingent consideration and holdbacks


	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Change in fair value of contingent consideration and holdbacks	$	—	$	(581)	$	581	(100)	%

There was no change in fair value of contingent consideration and holdbacks for the three months ended June 30, 2024 as the contingent consideration and holdbacks liabilities were settled in the prior year. During the three months ended June 30, 2023, we recognized a change in fair value of holdbacks of $0.6 million related to the acquisition of AbX Biologics, Inc. ("Abveris') primarily as a result of the change in fair value of our stock price as of June 30, 2023.

Impairment of long-lived assets

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	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Impairment of long-lived assets	$	44,930	$	3,620	$	41,310	1,141	%

We recognized impairment of intangible assets and property and equipment of $44.9 million related to the Biopharma asset group during the three months ended June 30, 2024 (see discussion in critical accounting policies and significant management estimates — impairment of long-lived assets below), as compared to impairment of property and equipment of $3.6 million during the three months ended June 30, 2023 related primarily to costs associated with transferring assets between labs and professional service assistance related to the 2023 restructuring plan.

Interest and other income (expense), net


	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Interest income	$	3,663	$	3,968	$	(305)	(8)	%
Interest expense	—		(1)		1		(100)	%
Other expense	(121)		41		(162)		(395)	%
Total interest and other income (expense), net	$	3,542	$	4,008	$	(466)	(12)	%

Interest income decreased 8% to $3.7 million for the three months ended June 30, 2024, as compared to $4.0 million for the three months ended June 30, 2023, resulting from a decrease in cash equivalents and short-term investments balances.

Income tax provision


	Three months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Income tax provision	$	(191)	$	(622)	$	431	(69)	%

We recorded an income tax provision of $0.2 million and $0.6 million for the three months ended June 30, 2024 and June 30, 2023, respectively.

Comparison of the nine months ended June 30, 2024 and 2023

Revenues


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Revenues	$	228,264	$	178,163	$	50,101	28	%

Revenues increased 28% to $228.3 million for the nine months ended June 30, 2024, as compared to $178.2 million for the nine months ended June 30, 2023. The increase in revenue reflects growth in NGS tools revenue of $37.0 million and growth in synthetic genes revenue of $13.5 million, including the Express Genes product line. The increase is primarily attributable to our top customers in the healthcare, industrial chemicals/materials and academic research industries and an increase in customers. The number of our genes shipped in the nine months ended June 30, 2024 increased to approximately 576,000 genes, compared to approximately 457,000 genes in the nine months ended June 30, 2023, an increase of 26%.

Cost of revenues

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	Nine months ended June 30,
(in thousands, except percentages)	2024			2023			Change			%
Cost of revenues	$	133,148		$	112,956		$	20,192		18	%
Gross profit	$	95,116		$	65,207		$	29,909		46	%
Gross margin	41.7		%	36.6		%	5.1		%

Cost of revenues increased 18% to $133.1 million for the nine months ended June 30, 2024, as compared to $113.0 million for the nine months ended June 30, 2023. The increase is primarily attributable to an increase in material costs of $14.9 million, due to higher sales volume, and an increase in depreciation and amortization expense of $4.4 million primarily due to the capital investment to increase manufacturing capacity in prior years. The remaining increase is attributable to an increase in lab supplies. Gross margin increased 507 basis points to 41.7% for the nine months ended June 30, 2024 as compared to 36.6% for the nine months ended June 30, 2023 mainly due to increase in revenue and the fixed costs being spread over larger revenue base resulting in an increase in gross margin.

Research and development expenses


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Research and development	$	69,718	$	83,148	$	(13,430)	(16)	%

Research and development expenses decreased 16% to $69.7 million for the nine months ended June 30, 2024, as compared to $83.1 million for the nine months ended June 30, 2023. The decrease is primarily due to decreases in personnel costs of $8.2 million, including stock-based compensation expense of $2.2 million, due to the reduction of headcount related to the 2023 restructuring plan, lab supplies of $5.3 million, depreciation and amortization expense of $0.7 million, and outside service costs of $1.5 million. These decreases are partially offset by a lack of grant reimbursement in 2024 where we received $2.7 million in 2023, which are netted against the research and development expenses.

Selling, general and administrative


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Selling, general and administrative	$	165,256	$	142,347	$	22,909	16	%

Selling, general and administrative expenses increased 16% to $165.3 million for the nine months ended June 30, 2024, as compared to $142.3 million for the nine months ended June 30, 2023. The increase is primarily due to an increase in personnel costs of $32.1 million, including an increase in stock-based compensation expense of $23.4 million. The increase in stock-based compensation expense is due to a reversal of $15.9 million in the first quarter 2023 because of employee stock forfeitures related to an acquisition performance condition not being met and the remaining increase is due to stock based awards granted to existing and new employees. Further, the increase is attributable to increases in facilities costs of $3.3 million, IT-related service costs of $3.2 million, marketing costs of $2.2 million and depreciation and amortization expense of $0.8 million. These increases are partially offset by the decrease in the Wilsonville manufacturing facility pre-commercialization costs of $18.5 million, which was completed when the Wilsonville manufacturing facility began shipping product in January 2023.

Restructuring and other costs


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Restructuring and other costs	$	—	$	9,052	$	(9,052)	100	%

We recognized restructuring and other costs of $9.1 million during the nine months ended June 30, 2023 resulting from the 2023 restructuring plan.

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Change in fair value of contingent consideration and holdbacks


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Change in fair value of contingent consideration and holdbacks	$	—	$	(5,913)	$	5,913	(100)	%

There was no change in fair value of contingent consideration and holdbacks for the nine months ended June 30, 2024 as the contingent consideration and holdbacks liabilities were settled in the prior year. During the nine months ended June 30, 2023, we recognized a change in fair value of the contingent consideration and holdbacks of $5.5 million and $0.4 million related to the acquisitions of Abveris and iGenomX, as a result of not achieving the Abveris revenue target for calendar year 2022 and a change in fair value of our stock price as of June 30, 2023.

Impairment of long-lived assets


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Impairment of long-lived assets	$	44,930	$	3,620	$	41,310	1,141	%

We recognized impairment of intangible assets and property and equipment of $44.9 million related to the Biopharma asset group during the nine months ended June 30, 2024 (see discussion in critical accounting policies and significant management estimates — impairment of long-lived assets below), as compared to impairment of property and equipment of $3.6 million during the nine months ended June 30, 2023 related primarily to costs associated with transferring assets between labs and professional service assistance related to the 2023 restructuring plan.

Interest and other income (expense), net


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Interest income	$	11,724	$	10,472	$	1,252	12	%
Interest expense	—		(4)		4		(100)	%
Other expense	(351)		(422)		71		(17)	%
Total interest and other income (expense), net	$	11,373	$	10,046	$	1,327	13	%

Interest income increased 12% to $11.7 million for the nine months ended June 30, 2024, as compared to $10.5 million for the nine months ended June 30, 2023, resulting from an increase in interest rates on our cash equivalents and short-term investments.

Income tax provision


	Nine months ended June 30,
(in thousands, except percentages)	2024		2023		Change		%
Income tax provision	$	(656)	$	(1,374)	$	718	(52)	%

We recorded an income tax provision of $0.7 million and $1.4 million during the nine months ended June 30, 2024 and June 30, 2023, respectively.

Liquidity and capital resources

Sources of liquidity

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To date, we have financed our operations principally through public equity raises, private placements of our convertible preferred stock, borrowings from credit facilities and revenue from our commercial operations.

Since our inception on February 4, 2013 and through June 30, 2024, we have received an aggregate of $1,333.7 million in net proceeds from the issuance of equity securities in public offerings and an aggregate of $13.8 million from debt issuances. At June 30, 2024, we had a balance of $239.1 million of cash and cash equivalents and $50.3 million in short-term investments.

Operating capital requirements

Our primary uses of capital are, and we expect will continue to be for the near future, compensation and related expenses, manufacturing costs, laboratory and related supplies, legal and other regulatory expenses and general overhead costs and capital expenditures. We had $1.1 million in commitments for capital expenditures as of June 30, 2024.

Cash flows

The following table summarizes our sources and uses of cash and cash equivalents:


	Nine months ended June 30,
(in thousands)	2024		2023
Net cash used in operating activities	$	(48,774)	$	(121,770)
Net cash provided by (used in) investing activities	(1,786)		52,859
Net cash provided by financing activities	3,263		469

Operating activities

Net cash used in operating activities was $48.8 million during the nine months ended June 30, 2024 and consisted primarily of a net loss of $174.1 million adjusted for non-cash items including depreciation and amortization expense of $24.8 million, stock-based compensation expense of $38.6 million, impairment of long-lived assets of $44.9 million and a net change in operating assets and liabilities of $16.6 million. The change in operating assets and liabilities was mainly due to decreases in accounts receivable of $11.4 million, inventories of $3.6 million, other non-current assets of $0.5 million, accounts payable of $6.9 million and other liabilities of $1.8 million offset by increases in prepaid expenses of $0.2 million, accrued compensation of $5.9 million and accrued expenses of $4.1 million.

Net cash used in operating activities was $121.8 million during the nine months ended June 30, 2023 and consisted primarily of a net loss of $158.4 million adjusted for non-cash items including depreciation and amortization expenses of $20.8 million, stock-based compensation expense of $18.5 million, non-cash lease expense of $1.0 million, change in fair value of contingent consideration of $5.9 million, and a net change in operating assets and liabilities of $1.5 million. The change in operating assets and liabilities was mainly due to increases in inventories of $2.9 million, other non-current assets of $1.1 million and accounts payable of $4.4 million offset by decreases in accounts receivable of $2.5 million, prepaid expenses of $1.9 million, accrued compensation of $0.3 million, accrued expenses of $1.3 million and other liabilities of $1.8 million.

Investing activities

Net cash used in investing activities was $1.8 million during the nine months ended June 30, 2024, which consisted of the purchases of laboratory property, equipment and computers of $3.1 million offset by the proceeds from the net impact of purchases and maturity of investments of $1.3 million.

In the nine months ended June 30, 2023, our investing activities generated net cash of $52.9 million. The net cash was generated primarily from the net impact of purchases, sale and maturity of investments of $78.2 million and purchases of laboratory property, equipment and computers of $25.4 million.

Financing activities

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Net cash provided by financing activities was $3.3 million in the nine months ended June 30, 2024, which consisted of $5.2 million from the exercise of stock options and $2.0 million proceeds from issuance of shares under the 2018 ESPP offset by $4.0 million in repurchases of common stock for income tax withholdings.

Net cash provided by financing activities was $0.5 million in the nine months ended June 30, 2023, which consisted of $2.5 million from proceeds from issuance of shares under the 2018 ESPP and $1.2 million from the exercise of stock options, offset by $3.3 million in repurchases of common stock for income tax withholdings.

Off-balance sheet arrangements

We do not have any off-balance sheet arrangements.

Contractual obligations and other commitments

Our contractual obligations have not materially changed from those reported in our Annual Report on Form 10-K.

Critical accounting policies and significant management estimates

The preparation of our Condensed Consolidated Financial Statements in accordance with generally accepted accounting principles in the United States of America requires management to make estimates and judgments that affect the reported amounts in the financial statements and related disclosures. On an ongoing basis, we evaluate our significant accounting policies and estimates. We base our estimates on historical experience and on various market-specific and other relevant assumptions that we believe to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Estimates are assessed each period and updated to reflect current information. Actual results may differ significantly from these estimates. A summary of our critical accounting policies and estimates is presented in Part II, Item 7 of our Annual Report on Form 10-K for the year ended September 30, 2023. There were no other material changes to our critical accounting policies and estimates during the nine months ended June 30, 2024 other than the updates to the critical accounting policies and estimates set forth below.

Valuation of long-lived assets

We recorded impairment charges totaling $44.9 million related to property and equipment and finite-lived intangible assets which are included in “Impairment of long-lived assets” on our condensed consolidated statements of operations and comprehensive loss for the three and nine months ended June 30, 2024.

During the three months ended June 30, 2024, we identified an impairment indicator with respect to an asset group associated with our antibody discovery services product line (“Biopharma asset group”) due to lower than forecasted revenues. Therefore, we performed a recoverability test of long-lived assets by comparing the net book value of the long-lived asset group, to the future undiscounted net cash flows attributable to such assets. We concluded that the carrying value of the asset group was not recoverable as it exceeded the future undiscounted cash flows the assets are expected to generate from the use and eventual disposition of the asset group.

To measure, allocate and recognize the impairment loss, we estimated the fair value of the Biopharma asset group by applying a discounted cash flow method. Calculating the fair value of an asset group involves significant estimates and assumptions. These estimates and assumptions include, among others, the level and timing of revenues, operating expenses, taxes, and working capital, capital asset requirements over the remaining life of the primary asset in the asset group, and discount rates, we believe to be consistent with the inherent risks associated with the asset group, which was approximately 14%. Changes in these factors and assumptions used can materially affect the amount of impairment loss recognized in the period the asset group was considered impaired.

The implied allocated impairment loss to any individual asset within the long-lived asset group shall not reduce the carrying amount of that asset below its fair value. We estimated the fair value of the developed technology intangible asset and the customer relationships intangible assets using an excess earnings model (income approach). We estimated the fair value of the trade name intangible asset using a relief from royalty approach. Key assumptions include the level and timing of expected future revenue, conditions and demands specific to each intangible asset over its remaining useful life. The fair value of these intangible assets is primarily affected by the projected revenues, gross margins, operating expenses, and the

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anticipated timing of the projected income associated with each intangible asset coupled with the discount rates used to derive their estimated present values.

After consideration of the impairment charge recorded in the current quarter, the remaining carrying amount of long-lived assets within the Biopharma asset group is approximately $11.6 million, which primarily comprises of lease right-of-use assets. We believe the remaining long-lived assets of Biopharma asset group are not presently at risk for future impairment.

Recent issued accounting pronouncements

For a description of accounting changes and recent accounting pronouncements, including the expected dates of adoption and estimated effects, if any, on our condensed consolidated financial statements, see Note 2, “Summary of significant accounting policies” in Item 1 of Part I of this Quarterly Report on Form 10-Q.

Item 3. Quantitative and qualitative disclosures about market risk

Interest rate sensitivity

We are exposed to market risk related to changes in interest rates. We had cash, cash equivalents, and marketable securities of $289.4 million and $336.4 million as of June 30, 2024 and September 30, 2023, respectively, which consisted primarily of money market funds and marketable securities, largely composed of investment grade, short to intermediate term fixed income securities.

The primary objective of our investment activities is to preserve capital to fund our operations. We also seek to maximize income from our investments without assuming significant risk. To achieve our objectives, we maintain a portfolio of investments in a variety of securities of high credit quality and short-term duration, according to our board-approved investment policy. Our investments are subject to interest rate risk and could fall in value if market interest rates increase. A hypothetical 10% relative change in interest rates during any of the periods presented would not have a material impact on our condensed consolidated financial statements.

Foreign currency sensitivity

The majority of our transactions occur in U.S. dollars. However, we do have certain transactions that are denominated in currencies other than the U.S. dollar, primarily the Euro, Chinese Yuan, and British Pound, and we therefore are subject to foreign exchange risk. The fluctuation in the value of the U.S. dollar against other currencies affects the reported amounts of expenses, assets and liabilities primarily associated with a limited number of manufacturing activities.

We do not use derivative financial instruments for speculative trading purposes, nor do we hedge foreign currency exchange rate exposure in a manner that entirely offsets the effects of changes in foreign currency exchange rates. The counterparties to these forward foreign currency exchange contracts are creditworthy multinational commercial banks, which minimizes the risk of counterparty nonperformance. We regularly review our exposure and may, as part of this review, make changes to it.

Inflation risk

While we have experienced increased operating costs in recent periods, which we believe are due in part to the recent growth in inflation, we do not believe that inflation has had a material effect on our business, financial condition or results of operations. If our costs were to become subject to significant inflationary pressures, we may not be able to fully offset such higher costs through price increases. Our inability or failure to do so could adversely affect our business, financial condition and results of operations.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, we evaluated the effectiveness of our disclosure controls and procedures (as that term is defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act) as of June 30, 2024, which is the end of the period covered by this Quarterly Report. Based on this evaluation, the Chief Executive Officer and Chief Financial Officer concluded that the Company’s disclosure controls and procedures to ensure that information required to be disclosed by the Company in reports we file or submit under the Exchange Act is (i) recorded, processed, summarized, evaluated and reported, as

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applicable, within the time periods specified in the SEC’s rules and forms and (ii) accumulated and communicated to the Company’s management, including the Company’s Chief Executive Officer and Chief Financial Officer, as appropriate to allow timely decisions regarding required disclosures were not effective as of June 30, 2024 due to the material weakness in internal control over financial reporting described in Part II, Item 9A of the Annual Report on Form 10-K for the fiscal year ended September 30, 2023.

Notwithstanding the material weakness, the Company performed additional analysis and other post-closing procedures to determine its condensed consolidated financial statements are prepared in accordance with generally accepted accounting principles. Accordingly, management believes that the unaudited condensed consolidated financial statements contained in this Quarterly Report on Form 10-Q fairly present, in all material respects, our financial condition, results of operations and cash flows for the periods presented in conformity with accounting principles generally accepted in the United States of America.

Because of the inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Previously Identified Material Weaknesses

A material weakness is a deficiency, or a combination of deficiencies, in internal control over financial reporting, such that there is a reasonable possibility that a material misstatement of annual or interim financial statements would not be prevented or detected on a timely basis.

Refer to the management report on internal control over financial reporting in Part II, Item 9A of our Annual Report on Form 10-K for a discussion of the material weakness existing as of September 30, 2023, which continued to exist as of June 30, 2024.

Remediation Plan of Material Weaknesses

As previously described in Part II, Item 9A of our Annual Report on Form 10-K, we are continuing to enhance our overall control environment and are devoting substantial effort by enhancing our manual and automated controls to remediate the identified material weakness. For a more comprehensive discussion of the remedial measures which are being undertaken to address these material weaknesses, or the Remediation Plan, refer to Part II, Item 9A, “Remediation of Material Weaknesses,” of our Annual Report on Form 10-K.

Additional changes and improvements may be identified and adopted as we continue to evaluate and implement our Remediation Plan. These material weaknesses will not be considered remediated until the applicable controls operate for a sufficient period of time and management has concluded, through testing, that the enhanced control is operating effectively.

Changes in Internal Control over Financial Reporting

Except for actions taken under the Remediation Plan described above, there were no changes in our internal control over financial reporting identified in connection with the evaluation required by Rule 13a-15(d) and 15d-15(d) of the Exchange Act that occurred during the quarter ended June 30, 2024, that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

PART II. Other information

Item 1. Legal proceedings

For a description of material pending legal proceedings, see Note 6 “Commitments and Contingencies - Legal Matters” of the Notes to Condensed Consolidated Financial Statements included in Part I, Item 1 of this Quarterly Report on Form 10-Q, which is incorporated herein by reference. In addition, we are subject to various legal proceedings and claims arising in the ordinary course of business. Although occasional adverse decisions or settlements may occur, management believes that the final disposition of such matters will not have a material adverse effect on our business, financial position, results of operations or cash flows.

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Item 1A. Risk factors

In addition to the other information set forth in this Quarterly Report on Form 10-Q, you should carefully consider the risk factors and other cautionary statements described under the heading “Item 1A. Risk Factors” included in our Annual Report on Form 10-K filed with the SEC on November 21, 2023, as updated and supplemented in Part II, “Item 1A. Risk Factors” in our Quarterly Report on Form 10-Q filed with the SEC on February 2, 2024, which could materially affect our business, financial condition or future results. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially and adversely affect our business, financial condition or future results. There have been no material changes in our risk factors from those described in our Annual Report on Form 10-K, and our Quarterly Report on Form 10-Q filed with the SEC on February 2, 2024. We may disclose changes to risk factors or additional risk factors from time to time in our future filings with the SEC

Item 2. Unregistered sales of equity securities and use of proceeds

Sales of unregistered securities

None.

Item 3. Defaults upon senior securities

None.

Item 4. Mine safety disclosures

Not applicable.

Item 5. Other information

Rule 10b5-1 Trading Plans

During the fiscal quarter ended June 30, 2024, none of our directors or officers (as defined in Rule 16a-1(f) of the Exchange Act) informed us of the adoption, modification or termination of a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement” (both as defined in Item 408(a) of Regulation S-K).

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Item 6. Exhibits

Exhibit

Number

Description

Filed / Furnished /

Incorporated from

Form

31.1

Certification pursuant to Section 302 of the Sarbanes-Oxley Act of 2002, Rule 13(a)-14(a)/15d-14(a), by Chief Executive Officer.

Filed herewith

31.2

Certification pursuant to Section 302 of the Sarbanes-Oxley Act of 2002, Rule 13(a)-14(a)/15d-14(a), by Chief Financial Officer.

Filed herewith

32.1†

Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, by Chief Executive Officer.

Furnished herewith

32.2†

Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, by Chief Financial Officer.

Furnished herewith

101

The following materials from Twist Bioscience Corporation’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, formatted in iXBRL (inline eXtensible Business Reporting Language): (i) the Condensed Consolidated Balance Sheets, (ii) the Condensed Consolidated Statements of Operations and Comprehensive Loss, (iii) the Condensed Consolidated Balance Sheets, (iv) the Condensed Consolidated Statements of Stockholders’ Equity, (v) the Condensed Consolidated Statements of Cash Flows, and (vi) Notes to Unaudited Condensed Consolidated Financial Statements, tagged as blocks of text.

Filed herewith

104

The cover page from the Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, formatted in Inline XBRL (included in Exhibit 101).

Filed herewith



†			The certifications attached as Exhibits 32.1 and 32.2 that accompany this Quarterly Report on Form 10-Q are not deemed filed with the SEC and are not to be incorporated by reference into any filing of Twist Bioscience Corporation under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date of this Quarterly Report on Form 10-Q, regardless of any general incorporation language contained in any filing.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.


August 2, 2024	Twist Bioscience Corporation

	By:	/s/ Adam Laponis
		Adam Laponis
		Chief Financial Officer
		(Authorized officer)

Exhibit 31.1

Certification of Principal Executive Officer

pursuant to

Exchange Act Rules 13a-14(a) and 15d-14(a),

as adopted pursuant to

Section 302 of the Sarbanes-Oxley Act of 2002

I, Emily M. Leproust, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of Twist Bioscience Corporation for the quarter ended June 30, 2024;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting.

5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of registrant’s board of directors (or persons performing the equivalent functions):

a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.


			/s/ Emily M. Leproust
			Emily M. Leproust
			Chief Executive Officer
			(Principal Executive Officer)

Date: August 2, 2024

Exhibit 31.2

Certification of Principal Financial Officer

pursuant to

Exchange Act Rules 13a-14(a) and 15d-14(a),

as adopted pursuant to

Section 302 of the Sarbanes-Oxley Act of 2002

I, Adam Laponis, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of Twist Bioscience Corporation for the quarter ended June 30, 2024;

b.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.


			/s/ Adam Laponis
			Adam Laponis
			Chief Financial Officer

Date: August 2, 2024

Exhibit 32.1

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY

ACT OF 2002

In connection with the Quarterly Report of Twist Bioscience Corporation (the “Company”) on Form 10-Q for the quarterly period ended June 30, 2024, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Emily M. Leproust, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, that:

1.The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 2, 2024


			/s/ Emily M. Leproust
			Emily M. Leproust
			Chief Executive Officer
			(Principal Executive Officer)

Exhibit 32.2

CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY

ACT OF 2002

In connection with the Quarterly Report of Twist Bioscience Corporation (the “Company”) on Form 10-Q for the quarterly period ended June 30, 2024, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Adam Laponis, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, that:

1.The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 2, 2024


			/s/ Adam Laponis
			Adam Laponis
			Chief Financial Officer

Cover Page - shares	9 Months Ended
Cover Page - shares	Jun. 30, 2024	Jul. 31, 2024
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2024
Document Transition Report	false
Entity File Number	001-38720
Entity Registrant Name	Twist Bioscience Corporation
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	46-2058888
Entity Address, Address Line One	681 Gateway Blvd
Entity Address, City or Town	South San Francisco
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94080
City Area Code	800
Local Phone Number	719-0671
Title of 12(b) Security	Common Stock
Trading Symbol	TWST
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		58,585,960
Amendment Flag	false
Entity Central Index Key	0001581280
Current Fiscal Year End Date	--09-30
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q3

Condensed Consolidated Balance Sheets (unaudited) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Current assets:
Cash and cash equivalents	$ 239,142	$ 286,470
Short-term investments	50,276	49,943
Accounts receivable, net	31,988	44,064
Inventories	28,484	32,063
Prepaid expenses and other current assets	11,941	11,716
Total current assets	361,831	424,256
Property and equipment, net	106,339	131,830
Operating lease right-of-use assets	61,277	71,531
Goodwill	85,811	85,811
Intangible assets, net	14,741	54,483
Restricted cash, non-current	2,895	2,811
Other non-current assets	5,224	5,681
Total assets	638,118	776,403
Current liabilities:
Accounts payable	6,626	14,052
Accrued expenses	14,838	10,754
Accrued compensation	31,659	25,818
Current portion of operating lease liability	14,555	14,896
Other current liabilities	6,079	7,803
Total current liabilities	73,757	73,323
Operating lease liability, net of current portion	72,625	79,173
Other non-current liabilities	597	475
Total liabilities	146,979	152,971
Commitments and contingencies (Note 6)
Stockholders’ equity
Common stock, $0.00001 par value —100,000 and 100,000 shares authorized at June 30, 2024 and September 30, 2023, respectively; 58,519 and 57,557 shares issued and outstanding at June 30, 2024 and September 30, 2023, respectively	0	0
Additional paid-in capital	1,699,127	1,657,222
Accumulated other comprehensive income	(735)	(756)
Accumulated deficit	(1,207,253)	(1,033,034)
Total stockholders’ equity	491,139	623,432
Total liabilities and stockholders’ equity	$ 638,118	$ 776,403

Condensed Consolidated Balance Sheets (unaudited) (Parenthetical) - $ / shares shares in Thousands	Jun. 30, 2024	Sep. 30, 2023
Statement of Financial Position [Abstract]
Common stock, par value (in usd per share)	$ 0.00001	$ 0.00001
Common stock, authorized (in shares)	100,000	100,000
Common stock, issued (in shares)	58,519	57,557
Common stock, outstanding (in shares)	58,519	57,557

Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) - USD ($)
shares in Thousands, $ in Thousands

3 Months Ended

9 Months Ended

Jun. 30, 2024

Jun. 30, 2023

Jun. 30, 2024

Jun. 30, 2023

Statement of Comprehensive Income [Abstract]

Revenues

^[1]

$ 81,464

$ 63,740

$ 228,264

$ 178,163

Operating expenses:

Cost of revenues

46,193

41,845

133,148

112,956

Research and development

22,469

24,528

69,718

83,148

Selling, general and administrative

56,794

46,057

165,256

142,347

Restructuring and other costs

9,052

Impairment of long-lived assets

44,930

3,620

44,930

3,620

Change in fair value of contingent considerations and holdbacks

(581)

(5,913)

Total operating expenses

170,386

124,521

413,052

345,210

Loss from operations

(88,922)

(60,781)

(184,788)

(167,047)

Interest income

3,663

3,968

11,724

10,472

Interest expense

(1)

(4)

Other income (expense), net

(121)

(351)

(422)

Loss before income taxes

(85,380)

(56,773)

(173,415)

(157,001)

Income tax provision

(191)

(622)

(656)

(1,374)

Net loss attributable to common stockholders

(85,571)

(57,395)

(174,071)

(158,375)

Other comprehensive loss:

Change in unrealized gain (loss) on investments

(21)

(208)

1,308

Foreign currency translation adjustment

(54)

(538)

(35)

(100)

Comprehensive loss

$ (85,646)

$ (58,141)

$ (174,050)

$ (157,167)

Net loss per share attributable to common stockholders—basic (in usd per share)

$ (1.47)

$ (1.01)

$ (3.01)

$ (2.79)

Net loss per share attributable to common stockholders—diluted (in usd per share)

$ (1.47)

$ (1.01)

$ (3.01)

$ (2.79)

Weighted average shares used in computing net loss per share attributable to common stockholders—basic (in shares)

58,145

57,041

57,806

56,753

Weighted average shares used in computing net loss per share attributable to common stockholders—diluted (in shares)

58,145

57,041

57,806

56,753

[1]

During the three and nine months ended June 30, 2024, the Company generated revenues from related parties totaling of $4.1 million and $9.7 million, respectively. During the three and nine months ended June 30, 2023, the Company generated revenues from related parties totaling $0.9 million and $3.6 million, respectively.

Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) (Parenthetical) - USD ($)
$ in Thousands

3 Months Ended

9 Months Ended

Jun. 30, 2024

Jun. 30, 2023

Jun. 30, 2024

Jun. 30, 2023

Revenue

^[1]

$ 81,464

$ 63,740

$ 228,264

$ 178,163

Related Party

Revenue

$ 4,100

$ 900

$ 9,700

$ 3,600

[1]

Condensed Consolidated Statements of Stockholders’ Equity (unaudited) - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Common stock	Additional paid-in capital	Accumulated Other comprehensive loss	Accumulated deficit	Accumulated deficit Cumulative Effect, Period of Adoption, Adjustment
Beginning balance (in shares) at Sep. 30, 2022			56,523,000
Beginning balance at Sep. 30, 2022	$ 789,385		$ 0	$ 1,619,644	$ (1,843)	$ (828,416)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)			504,000
Exercise of stock options (in shares)			102,000
Exercise of stock options	1,195			1,195
Issuance of shares under the employee stock purchase program (in shares)			132,000
Issuance of shares under the employee stock purchase plan	2,536			2,536
Repurchases of common stock for income tax withholding (in shares)			(171,000)
Repurchases of common stock for income tax withholding	(3,275)			(3,275)
Issuance of shares associated with a business acquisition (in shares)			277,000
Issuance of shares from business acquisition	5,860			5,860
Stock-based compensation	19,016			19,016
Other comprehensive income (loss)	1,208				1,208
Net loss	(158,375)					(158,375)
Ending balance (in shares) at Jun. 30, 2023			57,367,000
Ending balance at Jun. 30, 2023	657,550		$ 0	1,644,976	(635)	(986,791)
Beginning balance (in shares) at Sep. 30, 2022			56,523,000
Beginning balance at Sep. 30, 2022	$ 789,385		$ 0	1,619,644	(1,843)	(828,416)
Ending balance (in shares) at Sep. 30, 2023	57,557,000		57,557,000
Ending balance at Sep. 30, 2023	$ 623,432	$ (148)	$ 0	1,657,222	(756)	(1,033,034)	$ (148)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Accounting standards update	Accounting Standards Update 2016-13 [Member]
Beginning balance (in shares) at Mar. 31, 2023			57,105,000
Beginning balance at Mar. 31, 2023	$ 703,932		$ 0	1,633,217	111	(929,396)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)			182,000
Exercise of stock options (in shares)			45,000
Exercise of stock options	342			342
Repurchases of common stock for income tax withholding (in shares)			(70,000)
Repurchases of common stock for income tax withholding	(1,014)			(1,014)
Issuance of shares associated with a business acquisition (in shares)			105,000
Issuance of shares from business acquisition	1,767			1,767
Stock-based compensation	10,664			10,664
Other comprehensive income (loss)	(746)				(746)
Net loss	(57,395)					(57,395)
Ending balance (in shares) at Jun. 30, 2023			57,367,000
Ending balance at Jun. 30, 2023	$ 657,550		$ 0	1,644,976	(635)	(986,791)
Beginning balance (in shares) at Sep. 30, 2023	57,557,000		57,557,000
Beginning balance at Sep. 30, 2023	$ 623,432	$ (148)	$ 0	1,657,222	(756)	(1,033,034)	$ (148)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)			712,000
Exercise of stock options (in shares)	261,000		261,000
Exercise of stock options	$ 5,183			5,183
Repurchases of common stock for income tax withholding (in shares)			(135,000)
Repurchases of common stock for income tax withholding	(3,967)			(3,967)
Issuance of shares associated with a business acquisition (in shares)			124,000
Issuance of shares from business acquisition	2,047			2,047
Stock-based compensation	38,642			38,642
Other comprehensive income (loss)	21				21
Net loss	$ (174,071)					(174,071)
Ending balance (in shares) at Jun. 30, 2024	58,519,000		58,519,000
Ending balance at Jun. 30, 2024	$ 491,139		$ 0	1,699,127	(735)	(1,207,253)
Beginning balance (in shares) at Mar. 31, 2024			58,162,000
Beginning balance at Mar. 31, 2024	560,131		$ 0	1,682,473	(660)	(1,121,682)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock units (in shares)			223,000
Exercise of stock options (in shares)			134,000
Exercise of stock options	2,915			2,915
Repurchases of common stock for income tax withholding	(7)			(7)
Stock-based compensation	13,746			13,746
Other comprehensive income (loss)	(75)				(75)
Net loss	$ (85,571)					(85,571)
Ending balance (in shares) at Jun. 30, 2024	58,519,000		58,519,000
Ending balance at Jun. 30, 2024	$ 491,139		$ 0	$ 1,699,127	$ (735)	$ (1,207,253)

Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Cash flows from operating activities
Net loss	$ (174,071)	$ (158,375)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization	24,776	20,810
Impairment of long-lived assets	44,930	3,620
Non-cash lease expense	647	1,040
Stock-based compensation	38,578	18,531
Change in fair value of acquisition consideration	0	(5,913)
Other non-cash adjustments	(185)	(33)
Changes in assets and liabilities:
Accounts receivable, net	11,398	(2,508)
Inventories	3,578	2,949
Prepaid expenses and other current assets	(185)	(1,935)
Other non-current assets	472	1,050
Accounts payable	(6,927)	(4,431)
Accrued expenses	4,132	1,278
Accrued compensation	5,932	348
Other liabilities	(1,849)	1,799
Net cash used in operating activities	(48,774)	(121,770)
Cash flows from investing activities
Purchases of property and equipment	(3,074)	(25,386)
Purchases of investments	(30,712)	(58,255)
Proceeds from maturity of investments	32,000	136,500
Net cash (used in) provided by investing activities	(1,786)	52,859
Cash flows from financing activities
Proceeds from exercise of stock options	5,183	1,208
Proceeds from issuance of common stock under employee stock purchase plan	2,047	2,536
Repurchases of common stock for income tax withholding	(3,967)	(3,275)
Net cash provided by financing activities	3,263	469
Effect of exchange rates on cash, cash equivalents and restricted cash	53	21
Net decrease in cash, cash equivalents, and restricted cash	(47,244)	(68,421)
Cash, cash equivalents, and restricted cash at beginning of period	289,281	380,259
Cash, cash equivalents, and restricted cash at end of period	242,037	311,838
Supplemental disclosure of cash flow information
Income taxes paid, net of refunds	363	241
Non-cash investing and financing activities
Property and equipment additions included in accounts payable and accrued expenses	226	1,686
Operating lease right-of-use assets obtained in exchange for operating lease liabilities	0	4,215
Issuance of common stock in connection with the business acquisition	0	5,860
Tenant improvement allowance capitalized in property and equipment	2,719	0
Conversion of convertible notes	$ 0	$ 3,711

The Company	9 Months Ended
The Company	Jun. 30, 2024
Organization, Consolidation and Presentation of Financial Statements [Abstract]
The Company	The Company Twist Bioscience Corporation (the Company) was incorporated in the state of Delaware on February 4, 2013. The Company is a synthetic biology and genomics company that has developed a disruptive DNA synthesis platform. DNA is used in many applications across different industries: industrial chemicals/materials, academic, healthcare and food/agriculture. The Company’s fiscal year ends on September 30. The core of the Company’s platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. The Company has combined this technology with proprietary software, scalable commercial infrastructure and an e-commerce platform to create an integrated technology platform that enables the Company to achieve high levels of quality, precision, automation, and manufacturing throughput at a significantly lower cost than its competitors. The Company is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next generation sample preparation, and antibody libraries for drug discovery and development. The Company has a limited operating history and its prospects are subject to risks, expenses and uncertainties frequently encountered by companies in this industry. These risks include, but are not limited to, the uncertainty of availability of additional financing, market acceptance of its products, the ability to retain and attract new customers, and the uncertainty of achieving future profitability. The Company has generated net losses in all periods since its inception. As of June 30, 2024, the Company had an accumulated deficit of $1,207.3 million and has not generated positive cash flows from operations since inception. Losses are expected to continue as the Company continues to invest in product development, manufacturing, and sales and marketing. As of June 30, 2024, the Company had cash and cash equivalents and short-term investments of $289.4 million, which the management believes will be sufficient to fund operations for at least one year from the issuance of these consolidated financial statements. However, if the Company needs to obtain additional financing to fund operations beyond this period, there can be no assurance that it will be successful in raising additional financing on terms which are acceptable to the Company. If the Company requires but is unable to obtain additional funding, the Company could be forced to delay, reduce or eliminate some or all of its research and development programs, product portfolio expansion or commercialization efforts, which could adversely affect its business prospects, or the Company may be unable to continue operations.

Summary of significant accounting policies

9 Months Ended

Jun. 30, 2024

Accounting Policies [Abstract]

Summary of significant accounting policies

Basis of presentation and use of estimates

condensed consolidated financial statements include its wholly owned subsidiaries. All intercompany balances and accounts are eliminated in consolidation.


(in thousands)	June 30, 2024		September 30, 2023
Cash and cash equivalents	$	239,142	$	286,470
Restricted cash, non-current	2,895		2,811
Total cash, cash equivalents and restricted cash	$	242,037	$	289,281

Restricted cash represents cash held at financial institutions that are pledged as collateral for stand-by letters of credit for lease commitments and is included in non-current assets.

Significant accounting policies

Allowance for Credit Losses

Short-term investments

Revenue

Recent accounting pronouncements

Recent accounting pronouncements adopted

Recently issued accounting pronouncement not yet adopted

Fair value measurement

9 Months Ended

Jun. 30, 2024

Fair Value Disclosures [Abstract]

Fair value measurement

Level 1—Quoted prices in active markets for identical assets or liabilities.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of June 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	239,142	$	—	$	—	$	239,142
Short-term investments:

U.S. government treasury bills	50,304		—		(29)		50,276
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	293,158	$	—	$	(29)	$	293,129

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of September 30, 2023:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	286,470	$	—	$	—	$	286,470
Short-term investments:
Corporate bonds	14,918		—		(29)		14,889
U.S. government treasury bills	35,111		—		(57)		35,054
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	340,210	$	—	$	(86)	$	340,124

As of June 30, 2024, financial assets and liabilities measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	196,413	$	—	$	—	$	196,413

U.S. government treasury bills	50,276		—		—		50,276
Non-current assets - investment in equity securities	—		—		3,711		3,711
Total	$	246,689	$	—	$	3,711	$	250,400

Total financial liabilities	$	—	$	—	$	—	$	—

As of September 30, 2023, financial assets and liabilities measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	245,654	$	—	$	—	$	245,654
Corporate bonds	—		14,889		—		14,889
U.S. government treasury bills	35,054		—		—		35,054
Non-current assets - investment in equity securities	—		—		3,711		3,711
Total financial assets	$	280,708	$	14,889	$	3,711	$	299,308

Total financial liabilities	$	—	$	—	$	—	$	—

The following table provides a reconciliation of beginning and ending balances of the Level 3 financial assets during the three months ended June 30, 2024:


(in thousands)	Equity investments		Total
Balance as of September 30, 2023	$	3,711	$	3,711
Change in fair value	—		—
Additions during the year	—		—
Balance as of June 30, 2024	$	3,711	$	3,711

Balance sheet components

9 Months Ended

Jun. 30, 2024

Balance Sheet Related Disclosures [Abstract]

Balance sheet components

Inventories consist of the following:


(in thousands)	June 30, 2024		September 30, 2023
Raw materials	$	22,000	$	27,024
Work-in-process	2,213		1,113
Finished goods	4,271		3,926
	$	28,484	$	32,063

There is no consigned inventory balance as of June 30, 2024 and September 30, 2023.

Property and Equipment, net consists of the following:


(in thousands)	June 30, 2024		September 30, 2023
Laboratory equipment	$	99,354	$	104,508
Furniture, fixtures and other equipment	3,279		3,484
Vehicles	211		85
Computer equipment	3,555		3,103
Computer software	9,077		5,507
Leasehold improvements	58,197		57,271
Construction in progress	3,296		8,528
	$	176,969	$	182,486
Less: Accumulated depreciation	(70,630)		(50,656)
	$	106,339	$	131,830

The other current liabilities consist of the following:


(in thousands)	June 30, 2024		September 30, 2023
Income and other taxes payable	$	2,343	$	4,374
Contract liabilities	2,940		2,999
Other current liabilities	796		430

	$	6,079	$	7,803

Goodwill and intangible assets

9 Months Ended

Jun. 30, 2024

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill and intangible assets

There were no changes to the carrying value of goodwill during the nine months ended June 30, 2024.

The goodwill balance is presented below:


(in thousands)	June 30, 2024		September 30, 2023
Balance at beginning of period/year	$	85,811	$	85,811
Balance at end of period/year	$	85,811	$	85,811

The intangible assets balances are presented below:


	June 30, 2024
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Impairment		Accumulated amortization		Net book value
Developed Technology	17	$	50,020	$	(25,198)	$	(10,081)	$	14,741
Customer Relationships	—	15,210		(10,541)		(4,669)		—
Tradenames & Trademarks	—	900		(125)		(775)		—
Total finite-lived intangible assets		$	66,130	$	(35,864)	$	(15,525)	$	14,741


	September 30, 2023
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Accumulated amortization		Net book value
Developed Technology	15	$	50,020	$	(7,636)	$	42,384
Customer Relationships	11	15,210		(3,461)		11,749
Tradenames & Trademarks	3	$	900	$	(550)	$	350
Total finite-lived intangible assets		$	66,130	$	(11,647)	$	54,483

Commitments and contingencies

9 Months Ended

Jun. 30, 2024

Commitments and Contingencies Disclosure [Abstract]

Commitments and contingencies

Legal proceedings

Securities Class Action

Derivative Action

Indemnifications

Leases

Supplemental balance sheet information related to the Company’s operating leases as of June 30, 2024 is as follows:


(in thousands)	June 30, 2024
Assets:
Operating lease right-of-use asset	$	61,277
Current liabilities:
Current portion of operating lease liabilities	$	14,555
Noncurrent liabilities:
Operating lease liabilities, net of current portion	$	72,625

Future minimum lease payments under all non-cancelable operating leases that have commenced as of June 30, 2024 are as follows:


(in thousands)	Operating leases
Years ending September 30:
Remainder of 2024	$	3,636
2025	14,814
2026	13,885
2027	8,371
2028	8,471
Thereafter	88,014
Total minimum lease payments	$	137,191
Less: imputed interest	(50,011)

Total operating lease liabilities	$	87,180
Less: current portion	(14,555)
Operating lease liabilities, net of current portion	$	72,625

Related party transactions	9 Months Ended
Related party transactions	Jun. 30, 2024
Related Party Transactions [Abstract]
Related party transactions	Related party transactions During the three months ended June 30, 2024 and 2023, the Company purchased raw materials from a related party in the amount of $1.7 million and $1.4 million, respectively. During the nine months ended June 30, 2024 and 2023, the purchases of raw materials from a related party were $4.5 million and $5.0 million, respectively. During the three and nine months ended June 30, 2024, the Company had revenues from the related party in the amount of $4.1 million and $9.7 million, respectively. During the three and nine months ended June 30, 2023, the Company generated revenues from the related party totaling $0.9 million and $3.6 million, respectively. As of June 30, 2024, payable balances and receivable balances with the related party were $0.2 million and $0.8 million, respectively. Receivable balances with the related party were $1.7 million as of September 30, 2023. Payable balances with the related parties were immaterial as of September 30, 2023.

Income taxes	9 Months Ended
Income taxes	Jun. 30, 2024
Income Tax Disclosure [Abstract]
Income taxes	Income taxesIn determining quarterly provisions for income taxes, the Company uses the annual estimated effective tax rate applied to the actual year-to-date profit or loss, adjusted for discrete items arising in that quarter. For the three and nine months ended June 30, 2024, the Company recorded provisions for income taxes of $0.2 million and $0.7 million, respectively. For the three and nine months ended June 30, 2023, the Company recorded provisions for income taxes of $0.6 million and $1.4 million, respectively.

Common stock	9 Months Ended
Common stock	Jun. 30, 2024
Equity [Abstract]
Common stock	Common stock As of June 30, 2024, the Company had reserved sufficient shares of common stock, with a par value of $0.00001 per share, for issuance upon exercise of outstanding stock options. Each share of common stock is entitled to one vote. The holders of shares of common stock are also entitled to receive dividends whenever funds are legally available and when declared by the board of directors.

Stock-based compensation

9 Months Ended

Jun. 30, 2024

Share-Based Payment Arrangement [Abstract]

Stock-based compensation

2018 Equity Incentive Plan

Inducement Equity Incentive Plan

Restricted Stock Units

Activity with respect to the Company’s restricted stock units during the nine months ended June 30, 2024 was as follows:


(in thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2023	1,620	$	40.73
Granted	1,414	26.10
Vested/Issued	(604)	39.61
Forfeited	(262)	40.08
Nonvested shares at June 30, 2024	2,168	$	31.62

Performance Stock Units

Activity under the PSUs during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2023	932	$	36.82
Granted	617	18.71
Vested/Issued	(84)	80.67
Forfeited	(81)	29.28
Nonvested shares at June 30, 2024	1,384	$	26.52

Options

Options activity during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2023	2,119	$	24.18	5.25	$	6,715
Forfeited	(115)	38.64		—	—
Exercised	(261)	19.85		—	5,123

Outstanding at June 30, 2024	1,743	$23.88		4.41	$	47,265
Nonvested at June 30, 2024	6	106.25		7.03	—
Exercisable at June 30, 2024	1,737	$	23.61	4.40	$	47,265

Performance Stock Options

of June 30, 2024, the Company determined that 30,000 shares are expected to vest based on the probability of the performance condition that will be achieved under this equity award program.

Activity under the PSOs during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2023	289	$	60.82	7.37	$	—
Nonvested at September 30, 2023	30	$	31.29	8.57	$	—
Exercisable at September 30, 2023	259	64.24		7.23	—
Forfeited	(12)	$	67.85	—	$	—
Exercisable at June 30, 2024	247	$	64.07	6.49	$	810
Nonvested at June 30, 2024	30	31.29		7.82	540
Outstanding at June 30, 2024	277	$	60.53	6.63	$	1,349

As of June 30, 2024, the unrecognized compensation costs related to these awards was $0.2 million. The Company expects to recognize those costs over a weighted average period of 0.8 years.

Total stock-based compensation expense recognized was as follows:


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Cost of revenues	$	1,033	$	1,286	$	3,006	$	3,898
Research and development	2,400		3,329		8,614		10,837
Selling, general and administrative	10,301		5,983		26,958		3,796
Total stock-based compensation	$	13,734	$	10,598	$	38,578	$	18,531

2018 Employee Stock Purchase Plan


(In thousands)						Shares available
Outstanding at September 30, 2023						539
Additional shares authorized						249
Shares issued during the period						(124)
Outstanding at June 30, 2024						664

401(k) Savings Plan

AbX Biologics, Inc. (Abveris) Acquisition

Net loss per share attributable to common stockholders

9 Months Ended

Jun. 30, 2024

Earnings Per Share [Abstract]

Net loss per share attributable to common stockholders

The following table sets forth the computation of the Company’s basic and diluted net loss per share attributable to common stockholders:


	Three months ended June 30,				Nine months ended June 30,
(in thousands, except per share data)	2024		2023		2024		2023
Numerator:
Net loss attributable to common stockholders	$	(85,571)	$	(57,395)	$	(174,071)	$	(158,375)
Denominator:
Weighted average shares used in computing net loss per share, basic and diluted	58,145		57,041		57,806		56,753
Net loss per share attributable to common stockholders, basic and diluted	$	(1.47)	$	(1.01)	$	(3.01)	$	(2.79)


	Three and nine months ended
	June 30,
(in thousands)	2024	2023
Shares subject to options (including performance options) to purchase common stock	2,020	2,546

Unvested restricted stock units and performance stock units	3,552	2,371
Shares subject to employee stock purchase plan	86	78
Total	5,658	4,995

Geographic, product and industry information

9 Months Ended

Jun. 30, 2024

Segment Reporting [Abstract]

Geographic, product and industry information


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Americas	$	51,389	$	39,016	$	141,221	$	107,586
EMEA	23,581		19,069		67,064		54,179
APAC	6,494		5,655		19,979		16,398
Total	$	81,464	$	63,740	$	228,264	$	178,163

The table below sets forth revenues by products.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Synthetic genes	$	24,948	$	19,302	$	67,031	$	53,488
Oligo pools	4,166		3,735		12,295		10,749
DNA libraries	3,848		2,880		10,318		7,542
Antibody discovery	5,102		4,580		15,029		19,785
NGS tools	43,400		33,243		123,591		86,599
Total	$	81,464	$	63,740	$	228,264	$	178,163

The table below sets forth revenues by industry.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Industrial chemicals/materials	$	23,188	$	16,801	$	59,730	$	44,785
Academic research	14,892		12,421		42,387		33,556
Healthcare	42,823		33,988		124,637		97,764
Food/agricultural	561		530		1,510		2,058
Total	$	81,464	$	63,740	$	228,264	$	178,163

Impairment of long-lived assets

9 Months Ended

Jun. 30, 2024

Restructuring and Related Activities [Abstract]

Impairment of long-lived assets

that the carrying value of the asset group was not recoverable as it exceeded the future undiscounted cash flows the assets are expected to generate from the use and eventual disposition.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Property and equipment	$	9,066	$	3,620	$	9,066	$	3,620
Finite-lived intangible assets	35,864		—		35,864		—
Total	$	44,930	$	3,620	$	44,930	$	3,620

During the three and nine months ended June 30, 2023, the Company recognized impairment of property and equipment. See note 14.

2023 Restructuring and other costs	9 Months Ended
2023 Restructuring and other costs	Jun. 30, 2024
Restructuring and Related Activities [Abstract]
2023 Restructuring and other costs	2023 Restructuring and other costs On May 3, 2023, the Company’s Board of Directors approved a strategic restructuring plan to reduce costs, build a leaner organization and increase operating efficiencies. The restructuring plan included a reduction in force which affected approximately 270 employees worldwide, representing approximately 25% of the Company’s total workforce. The majority of these employees separated from the Company by September 30, 2023. The reduction in force is subject to local regulatory requirements. Furthermore, as part of the plan the Company removed the duplication of synthetic biology production across its South San Francisco, California and Wilsonville, Oregon facilities. The plan was implemented beginning in May 2023 and was substantially completed by the end of fiscal year 2023. Total restructuring and other costs of $12.7 million was incurred by the Company during the three and nine months ended June 30, 2023 and included employee severance and related benefit costs of $8.6 million, restructuring and non-restructuring related impairment of property and equipment of $3.6 million, and other costs associated with restructuring of $0.4 million.

Pay vs Performance Disclosure - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Pay vs Performance Disclosure
Net loss attributable to common stockholders	$ (85,571)	$ (57,395)	$ (174,071)	$ (158,375)

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Jun. 30, 2024
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

Summary of significant accounting policies (Policies)	9 Months Ended
Summary of significant accounting policies (Policies)	Jun. 30, 2024
Accounting Policies [Abstract]
Basis of presentation and use of estimates	Basis of presentation and use of estimates The accompanying unaudited condensed consolidated financial statements were prepared in accordance with accounting principles generally accepted in the United States of America (GAAP) for interim financial information. Certain information and disclosures normally included in the consolidated financial statements prepared in accordance with GAAP have been condensed or omitted. Accordingly, these unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the related notes included in the Annual Report on Form 10-K for the fiscal year ended September 30, 2023 (the Annual Report on Form 10-K) filed with the Securities and Exchange Commission on November 21, 2023. The condensed consolidated financial statements are unaudited and have been prepared on a basis consistent with that used to prepare the audited annual consolidated financial statements and include, in the opinion of management, all adjustments, consisting of normal and recurring items, necessary for the fair statement of the condensed consolidated financial statements. The condensed consolidated balance sheet at September 30, 2023 is derived from audited consolidated financial statements but does not include all disclosures required by GAAP. The operating results for the three and nine months ended June 30, 2024 are not necessarily indicative of the results expected for the full year ending September 30, 2024 or any interim period. The presentation of unaudited condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the condensed consolidated financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates. The Company’s unaudited condensed consolidated financial statements include its wholly owned subsidiaries. All intercompany balances and accounts are eliminated in consolidation. To conform with current fiscal 2024 presentation, we reclassified $3.6 million of impairment of property and equipment included within restructuring and other costs to impairment of long-lived assets in the condensed consolidated statement of operations and comprehensive loss for the three and nine months ended June 30, 2023. This reclassification had no impact on our condensed statement of operations and comprehensive loss for the three and nine months ended June 30, 2023.
Allowance for Credit Losses	Allowance for Credit Losses The Company maintains an allowance for credit losses for expected uncollectible accounts receivable and contract assets, which is recorded as an offset to accounts receivable or contract assets and provisions for credit losses are recorded in general and administrative expense in the consolidated statements of income. Under the application of Accounting Standards Codification (“ASC”) Topic 326-20, Financial Instruments—Credit Losses (“ASC 326”), the allowance for current expected credit losses is based on a review of customer accounts and considers historical credit loss information that is adjusted for current economic and business conditions and anticipated future economic events that may impact collectability. In developing its expected credit loss estimate, the Company evaluated the appropriate grouping of accounts receivable and contract assets based upon its evaluation of risk characteristics, including consideration of region and industries of the customers. The allowance for credit losses is reviewed on a quarterly basis to assess the adequacy of the allowance.
Short-term investments	Short-term investments The Company invests in various types of securities, including United States government, commercial paper, and corporate debt securities. The Company classifies its investments as available-for-sale and records them at fair value based upon market prices at period end. For available-for-sale debt securities in an unrealized loss position, the Company evaluates whether a current expected credit loss exists based on available information relevant to the credit rating of the security, current economic conditions and reasonable and supportable forecasts. The allowance for credit loss is recorded in other income (expense), net, on the consolidated statements of income, not to exceed the amount of the unrealized loss. Any excess unrealized loss other than the credit loss is recognized in accumulated other comprehensive income or loss in the stockholders' equity section of the consolidated balance sheets. The cost of securities sold is based on the specific identification method and realized gains and losses are included in other income (expense), net. Dividend and interest income are recognized when earned. The Company may sell these securities at any time for use in current operations.
Revenue	Revenue The Company had contract assets of $2.6 million and contract liabilities of $2.9 million as of June 30, 2024. The Company had contract assets of $2.8 million and contract liabilities of $3.0 million as of September 30, 2023. For the three and nine months ended June 30, 2024, the Company recognized revenue of $0.7 million and $2.9 million, respectively, from the amount that was included in the contract liability balance at the beginning of each period. For the three and nine months ended June 30, 2023, the Company recognized revenue of $0.6 million and $2.8 million, respectively, from the amount that was included in the contract liability balance at the beginning of each period. In addition, for all periods presented, there was no revenue recognized in a reporting period from performance obligations satisfied in previous periods. The aggregate amount of the transaction price allocated to the performance obligations that are unsatisfied as of June 30, 2024 was $7.1 million. The Company expects to recognize revenue over the next twelve months relating to performance obligations unsatisfied as of June 30, 2024. Based on the nature of the Company's contracts with customers, which are recognized over a term of less than 12 months, the Company has elected to use the practical expedient whereby costs to obtain a contract are expensed as they are incurred. The Company states its revenues net of any taxes collected from customers that are required to be remitted to various government agencies. The amount of taxes collected from customers and payable to governmental entities is included on the balance sheet as part of “Accrued expenses and other current liabilities.”
Recent accounting pronouncements	Recent accounting pronouncements Changes to GAAP are established by the Financial Accounting Standards Board (“FASB”) in the form of accounting standards updates (“ASUs”) to the FASB’s ASC. The Company considered the applicability and impact of all recent ASUs. ASUs not listed below were assessed and determined to be not applicable to the Company’s consolidated financial position and results of operations. Recent accounting pronouncements adopted In June 2016, FASB issued ASU No. 2016-13 “Financial Instruments-Credit Losses: Measurement of Credit Losses on Financial Instruments” and has since modified the standard with several ASUs (collectively, “Topic 326”). Topic 326 requires measurement and recognition of expected credit losses for financial assets. The ASU replaced previous incurred loss impairment guidance and established a single expected credit losses allowance framework for financial assets carried at amortized cost. It also eliminated the concept of other-than-temporary impairment and requires credit losses related to certain available-for-sale debt securities to be recorded through an allowance for credit losses. On October 1, 2023, the Company adopted this standard using a modified retrospective approach, which requires a cumulative-effect adjustment to the opening balance of retained earnings to be recognized on the date of adoption and, accordingly, recorded a net increase of $0.1 million to accumulated deficit as of the beginning of fiscal 2024. In connection with the adoption of Topic 326, the Company made an accounting policy election to not measure an allowance for credit losses for accrued interest receivable. Recently issued accounting pronouncement not yet adopted In December 2023, the FASB issued ASU No. 2023-09 "Income Taxes (Topic 740)". The amendments in this ASU require that public business entities on an annual basis (1) disclose specific categories in the rate reconciliation and (2) provide additional information for reconciling items that meet a quantitative threshold. The amendments in this update are effective for annual periods beginning after December 15, 2024. The standard is not expected to have a material impact to the Company's condensed consolidated financial statements. In November 2023, the FASB issued ASU No. 2023-08 "Segment Reporting (Topic 280)". The amendments in this ASU improve reportable segment disclosure requirements, primarily through enhanced disclosures about significant segment expenses. The amendments in this update are effective for fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. The standard is not expected to have a material impact to the Company's condensed consolidated financial statements. The Company has evaluated other recently issued accounting pronouncements and has concluded that the impact of recently issued standards that are not yet effective will not have a material impact on the Company’s financial position or results of operations upon adoption.

Summary of significant accounting policies (Tables)

9 Months Ended

Jun. 30, 2024

Accounting Policies [Abstract]

Summary of Cash, Cash Equivalents and Restricted Cash


(in thousands)	June 30, 2024		September 30, 2023
Cash and cash equivalents	$	239,142	$	286,470
Restricted cash, non-current	2,895		2,811
Total cash, cash equivalents and restricted cash	$	242,037	$	289,281

Fair value measurement (Tables)

9 Months Ended

Jun. 30, 2024

Fair Value Disclosures [Abstract]

Summary of Cash and Cash Equivalents

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of June 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	239,142	$	—	$	—	$	239,142
Short-term investments:

U.S. government treasury bills	50,304		—		(29)		50,276
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	293,158	$	—	$	(29)	$	293,129

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of September 30, 2023:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	286,470	$	—	$	—	$	286,470
Short-term investments:
Corporate bonds	14,918		—		(29)		14,889
U.S. government treasury bills	35,111		—		(57)		35,054
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	340,210	$	—	$	(86)	$	340,124

Summary of Debt Securities Available-for-Sale

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of June 30, 2024:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	239,142	$	—	$	—	$	239,142
Short-term investments:

U.S. government treasury bills	50,304		—		(29)		50,276
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	293,158	$	—	$	(29)	$	293,129

The following table sets forth the cash and cash equivalents, short-term investments and equity securities as of September 30, 2023:


(in thousands)	Amortized cost		Gross unrealized gains		Gross unrealized losses		Fair value
Cash and cash equivalents	$	286,470	$	—	$	—	$	286,470
Short-term investments:
Corporate bonds	14,918		—		(29)		14,889
U.S. government treasury bills	35,111		—		(57)		35,054
Non-current assets - investment in equity securities	3,711		—		—		3,711
Total	$	340,210	$	—	$	(86)	$	340,124

Summary of Company's Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis

As of June 30, 2024, financial assets and liabilities measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	196,413	$	—	$	—	$	196,413

U.S. government treasury bills	50,276		—		—		50,276
Non-current assets - investment in equity securities	—		—		3,711		3,711
Total	$	246,689	$	—	$	3,711	$	250,400

Total financial liabilities	$	—	$	—	$	—	$	—

As of September 30, 2023, financial assets and liabilities measured and recognized at fair value are as follows:


(in thousands)	Level 1		Level 2		Level 3		Fair value
Assets
Money market funds	$	245,654	$	—	$	—	$	245,654
Corporate bonds	—		14,889		—		14,889
U.S. government treasury bills	35,054		—		—		35,054
Non-current assets - investment in equity securities	—		—		3,711		3,711
Total financial assets	$	280,708	$	14,889	$	3,711	$	299,308

Total financial liabilities	$	—	$	—	$	—	$	—

Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation

The following table provides a reconciliation of beginning and ending balances of the Level 3 financial assets during the three months ended June 30, 2024:


(in thousands)	Equity investments		Total
Balance as of September 30, 2023	$	3,711	$	3,711
Change in fair value	—		—
Additions during the year	—		—
Balance as of June 30, 2024	$	3,711	$	3,711

Balance sheet components (Tables)

9 Months Ended

Jun. 30, 2024

Balance Sheet Related Disclosures [Abstract]

Summary of Inventories

Inventories consist of the following:


(in thousands)	June 30, 2024		September 30, 2023
Raw materials	$	22,000	$	27,024
Work-in-process	2,213		1,113
Finished goods	4,271		3,926
	$	28,484	$	32,063

Summary of Property, Plant and Equipment

Property and Equipment, net consists of the following:


(in thousands)	June 30, 2024		September 30, 2023
Laboratory equipment	$	99,354	$	104,508
Furniture, fixtures and other equipment	3,279		3,484
Vehicles	211		85
Computer equipment	3,555		3,103
Computer software	9,077		5,507
Leasehold improvements	58,197		57,271
Construction in progress	3,296		8,528
	$	176,969	$	182,486
Less: Accumulated depreciation	(70,630)		(50,656)
	$	106,339	$	131,830

Summary of Other Current Liabilities

The other current liabilities consist of the following:


(in thousands)	June 30, 2024		September 30, 2023
Income and other taxes payable	$	2,343	$	4,374
Contract liabilities	2,940		2,999
Other current liabilities	796		430

	$	6,079	$	7,803

Goodwill and intangible assets (Tables)

9 Months Ended

Jun. 30, 2024

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of Goodwill balance

The goodwill balance is presented below:


(in thousands)	June 30, 2024		September 30, 2023
Balance at beginning of period/year	$	85,811	$	85,811
Balance at end of period/year	$	85,811	$	85,811

Summary of Intangible Assets

The intangible assets balances are presented below:


	June 30, 2024
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Impairment		Accumulated amortization		Net book value
Developed Technology	17	$	50,020	$	(25,198)	$	(10,081)	$	14,741
Customer Relationships	—	15,210		(10,541)		(4,669)		—
Tradenames & Trademarks	—	900		(125)		(775)		—
Total finite-lived intangible assets		$	66,130	$	(35,864)	$	(15,525)	$	14,741


	September 30, 2023
(in thousands, except for years)	Weighted average Amortization period in years	Gross carrying amount		Accumulated amortization		Net book value
Developed Technology	15	$	50,020	$	(7,636)	$	42,384
Customer Relationships	11	15,210		(3,461)		11,749
Tradenames & Trademarks	3	$	900	$	(550)	$	350
Total finite-lived intangible assets		$	66,130	$	(11,647)	$	54,483

Commitments and contingencies (Tables)

9 Months Ended

Jun. 30, 2024

Commitments and Contingencies Disclosure [Abstract]

Schedule of Supplemental Balance Sheet Information Relating to Companies Operating Lease

Supplemental balance sheet information related to the Company’s operating leases as of June 30, 2024 is as follows:


(in thousands)	June 30, 2024
Assets:
Operating lease right-of-use asset	$	61,277
Current liabilities:
Current portion of operating lease liabilities	$	14,555
Noncurrent liabilities:
Operating lease liabilities, net of current portion	$	72,625

Schedule of Future Minimum Rental Payments for Operating Leases

Future minimum lease payments under all non-cancelable operating leases that have commenced as of June 30, 2024 are as follows:


(in thousands)	Operating leases
Years ending September 30:
Remainder of 2024	$	3,636
2025	14,814
2026	13,885
2027	8,371
2028	8,471
Thereafter	88,014
Total minimum lease payments	$	137,191
Less: imputed interest	(50,011)

Total operating lease liabilities	$	87,180
Less: current portion	(14,555)
Operating lease liabilities, net of current portion	$	72,625

Stock-based compensation (Tables)

9 Months Ended

Jun. 30, 2024

Share-Based Payment Arrangement [Abstract]

Schedule of Nonvested Restricted Stock Units Activity

Activity with respect to the Company’s restricted stock units during the nine months ended June 30, 2024 was as follows:


(in thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2023	1,620	$	40.73
Granted	1,414	26.10
Vested/Issued	(604)	39.61
Forfeited	(262)	40.08
Nonvested shares at June 30, 2024	2,168	$	31.62

Schedule of Nonvested Performance-based Units Activity

Activity under the PSUs during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average grant date fair value per share
Nonvested shares at September 30, 2023	932	$	36.82
Granted	617	18.71
Vested/Issued	(84)	80.67
Forfeited	(81)	29.28
Nonvested shares at June 30, 2024	1,384	$	26.52

Schedule of Activity Under Option and Performance Stock Options

Options activity during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2023	2,119	$	24.18	5.25	$	6,715
Forfeited	(115)	38.64		—	—
Exercised	(261)	19.85		—	5,123

Outstanding at June 30, 2024	1,743	$23.88		4.41	$	47,265
Nonvested at June 30, 2024	6	106.25		7.03	—
Exercisable at June 30, 2024	1,737	$	23.61	4.40	$	47,265

Activity under the PSOs during the nine months ended June 30, 2024 is summarized below:


(in thousands, except per share data)	Shares	Weighted average exercise price per share		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Outstanding at September 30, 2023	289	$	60.82	7.37	$	—
Nonvested at September 30, 2023	30	$	31.29	8.57	$	—
Exercisable at September 30, 2023	259	64.24		7.23	—
Forfeited	(12)	$	67.85	—	$	—
Exercisable at June 30, 2024	247	$	64.07	6.49	$	810
Nonvested at June 30, 2024	30	31.29		7.82	540
Outstanding at June 30, 2024	277	$	60.53	6.63	$	1,349

Schedule of Stock-Based Compensation Expenses

Total stock-based compensation expense recognized was as follows:


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Cost of revenues	$	1,033	$	1,286	$	3,006	$	3,898
Research and development	2,400		3,329		8,614		10,837
Selling, general and administrative	10,301		5,983		26,958		3,796
Total stock-based compensation	$	13,734	$	10,598	$	38,578	$	18,531

Summary of Stock Option Valuation Assumptions

The number of shares reserved for issuance at June 30, 2024 was as follows:


(In thousands)						Shares available
Outstanding at September 30, 2023						539
Additional shares authorized						249
Shares issued during the period						(124)
Outstanding at June 30, 2024						664

Net loss per share attributable to common stockholders (Tables)

9 Months Ended

Jun. 30, 2024

Earnings Per Share [Abstract]

Summary of Computation of the Company's Basic and Diluted Net Loss Per Share Attributable to Common Stockholders

The following table sets forth the computation of the Company’s basic and diluted net loss per share attributable to common stockholders:


	Three months ended June 30,				Nine months ended June 30,
(in thousands, except per share data)	2024		2023		2024		2023
Numerator:
Net loss attributable to common stockholders	$	(85,571)	$	(57,395)	$	(174,071)	$	(158,375)
Denominator:
Weighted average shares used in computing net loss per share, basic and diluted	58,145		57,041		57,806		56,753
Net loss per share attributable to common stockholders, basic and diluted	$	(1.47)	$	(1.01)	$	(3.01)	$	(2.79)

Summary of Calculation of Diluted Net Loss Per Share


	Three and nine months ended
	June 30,
(in thousands)	2024	2023
Shares subject to options (including performance options) to purchase common stock	2,020	2,546

Unvested restricted stock units and performance stock units	3,552	2,371
Shares subject to employee stock purchase plan	86	78
Total	5,658	4,995

Geographic, product and industry information (Tables)

9 Months Ended

Jun. 30, 2024

Segment Reporting [Abstract]

Summary of Revenue by Geographic Region


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Americas	$	51,389	$	39,016	$	141,221	$	107,586
EMEA	23,581		19,069		67,064		54,179
APAC	6,494		5,655		19,979		16,398
Total	$	81,464	$	63,740	$	228,264	$	178,163

Summary of Revenue by Product

The table below sets forth revenues by products.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Synthetic genes	$	24,948	$	19,302	$	67,031	$	53,488
Oligo pools	4,166		3,735		12,295		10,749
DNA libraries	3,848		2,880		10,318		7,542
Antibody discovery	5,102		4,580		15,029		19,785
NGS tools	43,400		33,243		123,591		86,599
Total	$	81,464	$	63,740	$	228,264	$	178,163

Summary of Revenue by Industry

The table below sets forth revenues by industry.


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Industrial chemicals/materials	$	23,188	$	16,801	$	59,730	$	44,785
Academic research	14,892		12,421		42,387		33,556
Healthcare	42,823		33,988		124,637		97,764
Food/agricultural	561		530		1,510		2,058
Total	$	81,464	$	63,740	$	228,264	$	178,163

Impairment of long-lived assets (Tables)

9 Months Ended

Jun. 30, 2024

Restructuring and Related Activities [Abstract]

Details of Impairment of Long-Lived Assets Held and Used by Asset


	Three months ended June 30,				Nine months ended June 30,
(in thousands)	2024		2023		2024		2023
Property and equipment	$	9,066	$	3,620	$	9,066	$	3,620
Finite-lived intangible assets	35,864		—		35,864		—
Total	$	44,930	$	3,620	$	44,930	$	3,620

The Company (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated deficit	$ 1,207,253	$ 1,033,034
Cash, cash equivalents, and short-term investments	$ 289,400

Summary of significant accounting policies - Summary of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023	Jun. 30, 2023	Sep. 30, 2022
Accounting Policies [Abstract]
Cash and cash equivalents	$ 239,142	$ 286,470
Restricted cash, non-current	2,895	2,811
Total cash, cash equivalents and restricted cash	$ 242,037	$ 289,281	$ 311,838	$ 380,259

Summary of significant accounting policies - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Jan. 01, 2024	Sep. 30, 2023
Error Corrections and Prior Period Adjustments Restatement [Line Items]
Property and equipment	$ 9,066	$ 3,620	$ 9,066	$ 3,620
Accounts receivable, allowance for credit loss	700		700
Contract with customer, asset, after allowance for credit loss	2,600		2,600			$ 2,800
Contract with customer, liability	2,900		2,900			3,000
Contract with customer, liability, revenue recognized	700	600	2,900	2,800
Revenue, remaining performance obligation, amount	7,100		7,100
Accumulated deficit	$ (1,207,253)		$ (1,207,253)			$ (1,033,034)
Cumulative Effect, Period of Adoption, Adjustment
Error Corrections and Prior Period Adjustments Restatement [Line Items]
Accumulated deficit					$ (100)
Revision of Prior Period, Reclassification, Adjustment
Error Corrections and Prior Period Adjustments Restatement [Line Items]
Property and equipment		$ 3,600		$ 3,600

Fair value measurement - Cash And Cash Equivalents And Available For Sale Securities At Fair Value (Details) - USD ($) $ in Thousands	9 Months Ended	12 Months Ended
	Jun. 30, 2024	Sep. 30, 2023
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash and cash equivalents	$ 239,142	$ 286,470
Amortized cost	293,158	340,210
Gross unrealized gains	0	0
Gross unrealized losses	(29)	(86)
Cash and cash equivalents, fair value	239,142	286,470
Equity securities, FV-NI, cost	3,711	3,711
Equity securities, FV-NI, unrealized loss	0	0
Equity securities, FV-NI, unrealized gain	0	0
Non-current assets - investment in equity securities	3,711	3,711
Fair value	293,129	340,124
Corporate bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Short term investments, Amortized cost		14,918
Gross unrealized gains		0
Gross unrealized losses		(29)
Short term investments, fair value		14,889
U.S. government treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Short term investments, Amortized cost	50,304	35,111
Gross unrealized gains	0	0
Gross unrealized losses	(29)	(57)
Short term investments, fair value	$ 50,276	$ 35,054

Fair value measurement - Summary of Company's Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Assets
Total	$ 239,142	$ 286,470
Non-current assets - investment in equity securities	3,711	3,711
Total	250,400	299,308
Liabilities
Total financial liabilities	0	0
Corporate bonds
Assets
Short term investments, fair value		14,889
U.S. government treasury bills
Assets
Short term investments, fair value	50,276	35,054
Money market funds
Assets
Total	196,413	245,654
Level 1
Assets
Non-current assets - investment in equity securities	0	0
Total	246,689	280,708
Liabilities
Total financial liabilities	0	0
Level 1 \| Corporate bonds
Assets
Short term investments, fair value		0
Level 1 \| U.S. government treasury bills
Assets
Short term investments, fair value	50,276	35,054
Level 1 \| Money market funds
Assets
Total	196,413	245,654
Level 2
Assets
Non-current assets - investment in equity securities	0	0
Total	0	14,889
Liabilities
Total financial liabilities	0	0
Level 2 \| Corporate bonds
Assets
Short term investments, fair value		14,889
Level 2 \| U.S. government treasury bills
Assets
Short term investments, fair value	0	0
Level 2 \| Money market funds
Assets
Total	0	0
Level 3
Assets
Non-current assets - investment in equity securities	3,711	3,711
Total	3,711	3,711
Liabilities
Total financial liabilities	0	0
Level 3 \| Corporate bonds
Assets
Short term investments, fair value		0
Level 3 \| U.S. government treasury bills
Assets
Short term investments, fair value	0	0
Level 3 \| Money market funds
Assets
Total	$ 0	$ 0

Fair value measurement - Narrative (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Equity securities, FV-NI, cost	$ 3,711	$ 3,711
Equity ownership, excluding consolidated entity and equity method investee, percentage	15.00%
Fair value, measurement with unobservable inputs reconciliation, recurring basis, liability value	$ 3,700
Convertible Note \| Convertible Notes Payable
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Equity securities, FV-NI, cost	$ 3,500
Debt instrument, interest rate, stated percentage	4.00%
Prepaid Expenses and Other Current Assets
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Interest receivable	$ 1,000	$ 1,200

Fair value measurement - Summary of Reconciliation of Beginning and Ending Balances of the Level 3 Instruments (Details) $ in Thousands	9 Months Ended
	Jun. 30, 2024 USD ($)
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance as of September 30, 2023	$ 3,711
Change in fair value	0
Additions during the year	0
Balance as of June 30, 2024	$ 3,711
Fair value, liability, recurring basis, unobservable input reconciliation, gain (loss), statement of income or comprehensive income	Change In Fair Value Of Contingent Consideration And Indemnity Holdback
Equity Method Investments
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance as of September 30, 2023	$ 3,711
Change in fair value	0
Additions during the year	0
Balance as of June 30, 2024	$ 3,711

Balance sheet components - Inventory (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Balance Sheet Related Disclosures [Abstract]
Raw materials	$ 22,000	$ 27,024
Work-in-process	2,213	1,113
Finished goods	4,271	3,926
Total inventories	$ 28,484	$ 32,063

Balance sheet components - Summary of Property, Plant and Equipment (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 176,969	$ 182,486
Less: Accumulated depreciation	(70,630)	(50,656)
Property and equipment, net	106,339	131,830
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	99,354	104,508
Furniture, fixtures and other equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	3,279	3,484
Vehicles
Property, Plant and Equipment [Line Items]
Property and equipment, gross	211	85
Computer equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	3,555	3,103
Computer software
Property, Plant and Equipment [Line Items]
Property and equipment, gross	9,077	5,507
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment, gross	58,197	57,271
Construction in progress
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 3,296	$ 8,528

Balance sheet components - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Balance Sheet Related Disclosures [Abstract]
Depreciation	$ 7,000	$ 6,900	$ 20,900	$ 16,800
Property and equipment	$ 9,066	$ 3,620	$ 9,066	$ 3,620

Balance sheet components - Other current liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Balance Sheet Related Disclosures [Abstract]
Income and other taxes payable	$ 2,343	$ 4,374
Contract liabilities	2,940	2,999
Other current liabilities	796	430
Other current liabilities	$ 6,079	$ 7,803

Goodwill and intangible assets - Summary of Goodwill (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Goodwill [Roll Forward]
Balance at beginning of year	$ 85,811	$ 85,811
Balance at end of year	$ 85,811	$ 85,811

Goodwill and intangible assets - Intangible Assets Balances (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Sep. 30, 2023
Acquired Finite-Lived Intangible Assets [Line Items]
Gross carrying amount	$ 66,130		$ 66,130		$ 66,130
Impairment	(35,864)	$ 0	(35,864)	$ 0
Accumulated amortization	(15,525)		(15,525)		(11,647)
Intangible assets, net	$ 14,741		$ 14,741		$ 54,483
Developed Technology
Acquired Finite-Lived Intangible Assets [Line Items]
Weighted average Amortization period in years	17 years		17 years		15 years
Gross carrying amount	$ 50,020		$ 50,020		$ 50,020
Impairment	(25,198)
Accumulated amortization	(10,081)		(10,081)		(7,636)
Intangible assets, net	14,741		14,741		$ 42,384
Customer Relationships
Acquired Finite-Lived Intangible Assets [Line Items]
Weighted average Amortization period in years					11 years
Gross carrying amount	15,210		15,210		$ 15,210
Impairment	(10,541)
Accumulated amortization	(4,669)		(4,669)		(3,461)
Intangible assets, net	0		0		$ 11,749
Tradenames & Trademarks
Acquired Finite-Lived Intangible Assets [Line Items]
Weighted average Amortization period in years					3 years
Gross carrying amount	900		900		$ 900
Impairment	(125)
Accumulated amortization	(775)		(775)		(550)
Intangible assets, net	$ 0		$ 0		$ 350

Goodwill and intangible assets - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Goodwill and Intangible Assets Disclosure [Abstract]
Total amortization expense related to intangible assets	$ 1,300	$ 1,300	$ 3,900	$ 3,900
Impairment of intangible assets, finite-lived	$ 35,864	$ 0	$ 35,864	$ 0

Commitments and contingencies - Operating Leases On Balance Sheet (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Assets:
Operating lease right-of-use assets	$ 61,277	$ 71,531
Current liabilities:
Current portion of operating lease liability	14,555	14,896
Noncurrent liabilities:
Operating lease liability, net of current portion	$ 72,625	$ 79,173

Commitments and contingencies - Minimum Rental Payments (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Sep. 30, 2023
Commitments and Contingencies Disclosure [Abstract]
Remainder of 2024	$ 3,636
2025	14,814
2026	13,885
2027	8,371
2028	8,471
Thereafter	88,014
Total minimum lease payments	137,191
Less: imputed interest	(50,011)
Total operating lease liabilities	87,180
Less: current portion	(14,555)	$ (14,896)
Operating lease liability, net of current portion	$ 72,625	$ 79,173

Commitments and contingencies - Narrative (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Commitments and Contingencies Disclosure [Abstract]
Change in right-of-use asset			$ 7.5	$ 2.9
Change in operating lease liabilities			6.9	1.9
Operating lease expense	$ 3.8	$ 3.9	11.8	12.2
Operating lease payments	$ 3.7	$ 3.6	$ 11.1	$ 11.1
Lease weighted-average remaining lease term	15 years 2 months 12 days		15 years 2 months 12 days
Lease weighted average discount rate	6.50%		6.50%

Related party transactions - (Details) - USD ($)
$ in Thousands

3 Months Ended

9 Months Ended

12 Months Ended

Jun. 30, 2024

Jun. 30, 2023

Jun. 30, 2024

Jun. 30, 2023

Sep. 30, 2023

Raw materials purchased from related party investor

$ 1,700

$ 1,400

$ 4,500

$ 5,000

Revenue

^[1]

81,464

63,740

228,264

178,163

Accounts receivable, net

31,988

$ 44,064

Revenue

4,100

$ 900

9,700

$ 3,600

Accounts payable

200

Accounts receivable, net

$ 800

Related party consideration

$ 1,700

[1]

Income taxes (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
Income taxes (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Income Tax Disclosure [Abstract]
Income tax benefit	$ 191	$ 622	$ 656	$ 1,374

Common stock (Details)	9 Months Ended
Common stock (Details)	Jun. 30, 2024 vote $ / shares	Sep. 30, 2023 $ / shares
Equity [Abstract]
Common stock, par value (in usd per share) \| $ / shares	$ 0.00001	$ 0.00001
Number of votes per share \| vote	1

Stock-based compensation - Narrative (Details) $ in Thousands		3 Months Ended			9 Months Ended
	Sep. 26, 2018 shares	Jun. 30, 2024 USD ($) shares	Jun. 30, 2023 USD ($)	Dec. 31, 2022 USD ($)	Jun. 30, 2024 USD ($) shares	Jun. 30, 2023 USD ($)	Sep. 30, 2023 shares	Aug. 22, 2023 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost, options		$ 300			$ 300
Stock based compensation expense (reduction)		$ 13,734	$ 10,598		$ 38,578	$ 18,531
Share-based payment arrangement, amount capitalized			(100)			(500)
Aggregate number of common stock shares reserved for issuance (in shares) \| shares		664,000			664,000		539,000
Employer matching percentage					50.00%
Percentage of employee's gross pay matched					6.00%
Employer matching contributions		$ 700	$ 700		$ 2,000	$ 2,200
Abveris
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based payment arrangement, expense (credit)				$ (9,900)
Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					4 years
Conversion ratio					1
Unrecognized compensation cost, stock options		62,300			$ 62,300
Recognize cost weighted average period					2 years 7 months 6 days
Grant date fair value		36,900
Restricted Stock Units (RSUs) \| Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					1 year
Performance Stock Unit
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost, stock options		18,100			$ 18,100
Recognize cost weighted average period					1 year 3 months 18 days
Grant date fair value		11,500
Performance Stock Unit \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of PSUs that may vest based on performance					0.00%
Performance Stock Unit \| Minimum \| Employee
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					2 years
Performance Stock Unit \| Minimum \| Non-Employee
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					1 year
Performance Stock Unit \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of PSUs that may vest based on performance					150.00%
Performance Stock Unit \| Maximum \| Employee
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					3 years
Performance Stock Unit \| Maximum \| Non-Employee
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					3 years
Option
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					4 years
Recognize cost weighted average period					1 year 1 month 6 days
Award term					10 years
Performance Stock Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Recognize cost weighted average period					9 months 18 days
Award term					10 years
Unrecognized compensation cost, options		$ 200			$ 200
Performance Stock Options \| Executive Officers and Senior Level Employees
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					2 years
Vest outstanding (in shares) \| shares		30,000			30,000
Performance Stock Options \| Non-Employee
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period					5 years
2018 ESPP \| Shares subject to options (including performance options) to purchase common stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expense (reduction)		$ 500			$ 1,300
Aggregate number of common stock shares reserved for issuance (in shares) \| shares	275,225
Minimum annual increase in share reserved for issuance \| shares	249,470
Annual automatic Increase in share reserved for issuance (as a percent)	1.00%
Percentage of payroll deduction to purchase common stock	15.00%
ESPP eligible employee common stock purchase price ratio	85.00%
Inducement Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Maximum aggregate number of shares (in shares) \| shares								700,000

Stock-based compensation expense - Activity Under The Equity Incentive Plans (Details) shares in Thousands	9 Months Ended
	Jun. 30, 2024 $ / shares shares
Restricted Stock Unit
Number of Shares
Beginning balance (in shares) \| shares	1,620
Granted (in shares) \| shares	1,414
Vested/Issued (in shares) \| shares	(604)
Forfeited (in shares) \| shares	(262)
Ending balance (in shares) \| shares	2,168
Weighted average grant date fair value per share
Beginning balance (in usd per share) \| $ / shares	$ 40.73
Granted (in usd per share) \| $ / shares	26.10
Vested (in usd per share) \| $ / shares	39.61
Forfeited (in usd per share) \| $ / shares	40.08
Ending balance (in usd per share) \| $ / shares	$ 31.62
Performance Stock Unit
Number of Shares
Beginning balance (in shares) \| shares	932
Granted (in shares) \| shares	617
Vested/Issued (in shares) \| shares	(84)
Forfeited (in shares) \| shares	(81)
Ending balance (in shares) \| shares	1,384
Weighted average grant date fair value per share
Beginning balance (in usd per share) \| $ / shares	$ 36.82
Granted (in usd per share) \| $ / shares	18.71
Vested (in usd per share) \| $ / shares	80.67
Forfeited (in usd per share) \| $ / shares	29.28
Ending balance (in usd per share) \| $ / shares	$ 26.52

Stock-based compensation expense - Stock Option Activity (Details) $ / shares in Units, $ in Thousands	9 Months Ended	12 Months Ended
	Jun. 30, 2024 USD ($) $ / shares shares	Sep. 30, 2023 USD ($) $ / shares shares
Shares
Beginning balance (in shares) \| shares	2,119,000
Forfeited (in shares) \| shares	(115,000)
Exercised (in shares) \| shares	(261,000)
Ending balance (in shares) \| shares	1,743,000	2,119,000
Number of options, Nonvested at December 31, 2022 (in shares) \| shares	6,000
Number of options, Exercisable (in shares) \| shares	1,737,000
Weighted average exercise price per share
Beginning balance (in usd per share) \| $ / shares	$ 24.18
Forfeited (in usd per share) \| $ / shares	38.64
Exercised (in dollars per share) \| $ / shares	19.85
Ending balance (in usd per share) \| $ / shares	23.88	$ 24.18
Weighted average exercise price per share, Nonvested at December 31, 2022 (in dollars per share) \| $ / shares	106.25
Vested and exercisable (in usd per share) \| $ / shares	$ 23.61
Weighted average remaining contractual term (years)
Outstanding	4 years 4 months 28 days	5 years 3 months
Weighted average remaining contractual term (years), Nonvested at December 31, 2022	7 years 10 days
Weighted average remaining contractual term (years), Exercisable	4 years 4 months 24 days
Aggregate Intrinsic Value
Aggregate intrinsic value, outstanding beginning balance \| $	$ 6,715
Exercised \| $	5,123
Aggregate intrinsic value, nonvested \| $	0
Aggregate intrinsic value, Vested and exercisable \| $	47,265
Aggregate intrinsic value, outstanding ending balance \| $	$ 47,265	$ 6,715
Performance Stock Options
Shares
Beginning balance (in shares) \| shares	289,000
Forfeited (in shares) \| shares	(12,000)
Ending balance (in shares) \| shares	277,000	289,000
Number of options, Nonvested at December 31, 2022 (in shares) \| shares	30,000	30,000
Number of options, Exercisable (in shares) \| shares	247,000	259,000
Weighted average exercise price per share
Beginning balance (in usd per share) \| $ / shares	$ 60.82
Forfeited (in usd per share) \| $ / shares	67.85
Ending balance (in usd per share) \| $ / shares	60.53	$ 60.82
Weighted average exercise price per share, Nonvested at December 31, 2022 (in dollars per share) \| $ / shares	31.29	31.29
Vested and exercisable (in usd per share) \| $ / shares	$ 64.07	$ 64.24
Weighted average remaining contractual term (years)
Outstanding	6 years 7 months 17 days	7 years 4 months 13 days
Weighted average remaining contractual term (years), Nonvested at December 31, 2022	7 years 9 months 25 days	8 years 6 months 25 days
Weighted average remaining contractual term (years), Exercisable	6 years 5 months 26 days	7 years 2 months 23 days
Aggregate Intrinsic Value
Aggregate intrinsic value, outstanding beginning balance \| $	$ 0
Aggregate intrinsic value, nonvested \| $		$ 0
Aggregate intrinsic value, Vested and exercisable \| $	810	0
Aggregate intrinsic value, Nonvested at December 31, 2022 \| $	540
Aggregate intrinsic value, outstanding ending balance \| $	$ 1,349	$ 0

Stock-based compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expense	$ 13,734	$ 10,598	$ 38,578	$ 18,531
Cost of revenues
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expense	1,033	1,286	3,006	3,898
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expense	2,400	3,329	8,614	10,837
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expense	$ 10,301	$ 5,983	$ 26,958	$ 3,796

Stock-based compensation - Reserved For Issuance (Details) shares in Thousands	9 Months Ended
	Jun. 30, 2024 shares
Share-Based Compensation Arrangement By Share-based Payment Award, Outstanding [Roll Forward]
Beginning balance (in shares)	539
Additional shares authorized (in shares)	249
Shares issued during the period (in shares)	(124)
Ending balance (in shares)	664

Stock-based compensation - Abveris Acquisition (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Sep. 30, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expense (reduction)	$ 13,734	$ 10,598	$ 38,578	$ 18,531
Abveris \| Performance Shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expense (reduction)					$ 9,900

Net loss per share attributable to common stockholders - Computation (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Numerator:
Net loss attributable to common stockholders	$ (85,571)	$ (57,395)	$ (174,071)	$ (158,375)
Denominator:
Weighted average shares used in computing net loss per share, basic (in shares)	58,145	57,041	57,806	56,753
Weighted average shares used in computing net loss per share, diluted (in shares)	58,145	57,041	57,806	56,753
Net loss per share attributable to common stockholders—basic (in usd per share)	$ (1.47)	$ (1.01)	$ (3.01)	$ (2.79)
Net loss per share attributable to common stockholders, diluted (in usd per share)	$ (1.47)	$ (1.01)	$ (3.01)	$ (2.79)

Net loss per share attributable to common stockholders - Anti-dilutive (Details) - shares shares in Thousands	3 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	5,658	4,995
Shares subject to options (including performance options) to purchase common stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	2,020	2,546
Unvested restricted stock units and performance stock units
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	3,552	2,371
Shares subject to employee stock purchase plan
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	86	78

Geographic, product and industry information - Geographic Region (Details) - USD ($)
$ in Thousands

3 Months Ended

9 Months Ended

Jun. 30, 2024

Jun. 30, 2023

Jun. 30, 2024

Jun. 30, 2023

Segment Reporting Information [Line Items]

Revenue

^[1]

$ 81,464

$ 63,740

$ 228,264

$ 178,163

Americas

Segment Reporting Information [Line Items]

Revenue

51,389

39,016

141,221

107,586

EMEA

Segment Reporting Information [Line Items]

Revenue

23,581

19,069

67,064

54,179

APAC

Segment Reporting Information [Line Items]

Revenue

$ 6,494

$ 5,655

$ 19,979

$ 16,398

[1]

Geographic, product and industry information - By Product (Details) - USD ($)
$ in Thousands

3 Months Ended

9 Months Ended

Jun. 30, 2024

Jun. 30, 2023

Jun. 30, 2024

Jun. 30, 2023

Segment Reporting Information [Line Items]

Revenue

^[1]

$ 81,464

$ 63,740

$ 228,264

$ 178,163

Synthetic genes

Segment Reporting Information [Line Items]

Revenue

24,948

19,302

67,031

53,488

Oligo pools

Segment Reporting Information [Line Items]

Revenue

4,166

3,735

12,295

10,749

DNA libraries

Segment Reporting Information [Line Items]

Revenue

3,848

2,880

10,318

7,542

Antibody discovery

Segment Reporting Information [Line Items]

Revenue

5,102

4,580

15,029

19,785

NGS tools

Segment Reporting Information [Line Items]

Revenue

$ 43,400

$ 33,243

$ 123,591

$ 86,599

[1]

Geographic, product and industry information - By Industry (Details) - USD ($)
$ in Thousands

3 Months Ended

9 Months Ended

Jun. 30, 2024

Jun. 30, 2023

Jun. 30, 2024

Jun. 30, 2023

Segment Reporting Information [Line Items]

Revenue

^[1]

$ 81,464

$ 63,740

$ 228,264

$ 178,163

Industrial chemicals/materials

Segment Reporting Information [Line Items]

Revenue

23,188

16,801

59,730

44,785

Academic research

Segment Reporting Information [Line Items]

Revenue

14,892

12,421

42,387

33,556

Healthcare

Segment Reporting Information [Line Items]

Revenue

42,823

33,988

124,637

97,764

Food/agricultural

Segment Reporting Information [Line Items]

Revenue

$ 561

$ 530

$ 1,510

$ 2,058

[1]

Impairment of long-lived assets - Narrative (Details)	9 Months Ended
Impairment of long-lived assets - Narrative (Details)	Jun. 30, 2024
Restructuring and Related Activities [Abstract]
Intangible assets, Inherit risk percentage	0.14

Impairment of long-lived assets - Impairment (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Restructuring and Related Activities [Abstract]
Property and equipment	$ 9,066	$ 3,620	$ 9,066	$ 3,620
Finite-lived intangible assets	35,864	0	35,864	0
Impairment of long-lived assets	$ 44,930	$ 3,620	$ 44,930	$ 3,620

2023 Restructuring and other costs (Details) $ in Millions		3 Months Ended	9 Months Ended
2023 Restructuring and other costs (Details) $ in Millions	May 03, 2023 therapeutic	Jun. 30, 2023 USD ($)	Jun. 30, 2023 USD ($)
Restructuring Cost and Reserve [Line Items]
Restructuring and related cost, expected number of positions eliminated \| therapeutic	270
Restructuring and related cost, number of positions eliminated, period percent	25.00%
2023 Restructuring Plan
Restructuring Cost and Reserve [Line Items]
Total		$ 12.7	$ 12.7
2023 Restructuring Plan \| Severance and related benefit costs
Restructuring Cost and Reserve [Line Items]
Total		8.6	8.6
2023 Restructuring Plan \| Asset Impairments
Restructuring Cost and Reserve [Line Items]
Total		3.6	3.6
2023 Restructuring Plan \| Other associated costs
Restructuring Cost and Reserve [Line Items]
Total		$ 0.4	$ 0.4

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