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By Marta Falconi

Shire PLC (SHPG) said Thursday a one-time break-up fee related to a failed merger pushed fourth-quarter profits sharply higher, but cautioned its rate of sales growth may slow this year.

Dublin-based Shire said fourth-quarter profit soared to $2.17 billion, compared with $64 million in the year-earlier period, after it received $1.64 billion as a break-up fee following the collapse of a takeover attempt by AbbVie Inc. (ABBV) in October.

Sales in the quarter rose nearly 19% to $1.58 billion from $1.33 billion the year earlier. The performance beat the $1.55 billion forecast in a FactSet poll of analysts.

Still, the company said volatile exchange rates and the loss of exclusivity for one of its key products--attention deficit hyperactivity disorder treatment Intuniv--would push growth rates below last year's. Shire said it expects low-to-mid single digit product sales growth this year.

Shire's preferred measure of profit--non-GAAP diluted earnings per American depositary share, a figure that isn't calculated in line with U.S. generally accepted accounting principles--came in at $2.63. That was up 17% from the same quarter a year earlier.

Earnings growth is expected to be in the mid-single digits.

Shire is honing its focus in rare-disease treatments following the collapse of North Chicago, Ill.-based AbbVie's buyout.

AbbVie scrapped the acquisition, which was designed to lower its tax rate through the purchase of a foreign company, after the Obama administration took steps to deter so-called inversion deals.

Last month, Shire said it was acquiring New Jersey-based NPS Pharmaceuticals Inc., (NPSP) a maker of treatments for rare diseases, for $5.2 billion.

Sales of Shire's best-selling drug, the attention deficit and hyperactivity disorder treatment Vyvanse, rose 16% to $383.4 million in the quarter. The drug recently caught headlines when it won approval in the U.S. to treat some of the estimated 2.8 million adults there who have a binge-eating disorder.

Sales of Cinryze, which treats a hereditary disorder that causes swelling and was recently acquired by Shire, generated $142.4 million in the quarter.

Write to Marta Falconi at the marta.falconi@wsj.com

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