TIDMSHP 
 
 
   NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, 
DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO 
WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION 
 
   FOR IMMEDIATE RELEASE 
 
   NOVEMBER 12, 2018 
 
   RECOMMED OFFER 
 
   for 
 
   SHIRE PLC 
 
   by 
 
   TAKEDA PHARMACEUTICAL COMPANY LIMITED 
 
   Publication of Scheme Document 
 
   On May 8, 2018, Shire plc ("Shire") and Takeda Pharmaceutical Company 
Limited ("Takeda") announced that they had reached agreement on the 
terms of a recommended cash and share offer to be made by Takeda for the 
entire issued and to be issued share capital of Shire (the 
"Acquisition"). The Acquisition will be effected by means of a scheme of 
arrangement under Article 125 of the Companies (Jersey) Law 1991 (as 
amended) (the "Scheme"). 
 
   Shire is pleased to announce that the scheme document which sets out, 
among other things, a letter from the Chairman of Shire, the full terms 
and conditions of the Scheme, an explanatory statement, notices of the 
Court Meeting and the Shire General Meeting, an expected timetable of 
principal events and details of the action to be taken by Shire 
Shareholders and Shire ADS Holders, is being sent, or made available, to 
Shire Shareholders and Shire ADS Holders today and has been published on 
the Shire website at www.shire.com (the "Scheme Document"). 
 
   Together with the Scheme Document, Forms of Proxy for the Court Meeting 
and the Shire General Meeting and Forms of Election and the notes 
accompanying them have also been published on the Shire website at 
www.shire.com. Copies of these documents are also being sent to Shire 
Shareholders today. 
 
   A Notice of Court Meeting and Extraordinary General Meeting, together 
with an ADS Voting Card, is also being sent to Shire ADS Holders today 
by the Shire Depositary. 
 
   The Scheme Document, Forms of Proxy and Forms of Election will be 
available shortly on the National Storage Mechanism at 
www.morningstar.co.uk/uk/nsm. The Scheme Document has also been 
furnished to the SEC on Form 6-K and is available on the SEC's website 
at www.sec.gov. 
 
   Shire also notes Takeda's circular to shareholders published today, 
which relates to the convocation of the Takeda Extraordinary General 
Meeting scheduled to be held at 10.00 a.m. (Tokyo time) (1.00 a.m. 
(London time)) on December 5, 2018. This is available on Takeda's 
website at www.takeda.com/investors/offer-for-shire. 
 
   Unless otherwise defined, all capitalised terms in this announcement 
(the "Announcement") shall have the meaning given to them in the Scheme 
Document. 
 
   Notices of the Court Meeting and Shire General Meeting 
 
   As described in the Scheme Document, to become effective, the Scheme 
requires, among other things, the approval of Shire Shareholders at the 
Court Meeting, the passing of the Special Resolution at the Shire 
General Meeting and the subsequent sanction of the Court. The 
Acquisition is also subject to the satisfaction or waiver of the 
Conditions and certain further terms that are set out in the Scheme 
Document. 
 
   Notices of the Court Meeting and the Shire General Meeting, which are 
scheduled to be held at Block 3, Miesian Plaza, 50-58 Baggot Street 
Lower, Dublin 2, Ireland on December 5, 2018, are set out in the Scheme 
Document. The Court Meeting is scheduled to commence at 11.15 a.m. and 
the Shire General Meeting at 11.30 a.m. (or as soon thereafter as the 
Court Meeting has concluded or been adjourned). 
 
   It is important that, for the Court Meeting in particular, as many votes 
as possible are cast so that the Court may be satisfied that there is a 
fair and reasonable representation of Shire Shareholder opinion. Shire 
Shareholders and Shire ADS Holders are therefore strongly urged to 
complete, sign and return the Forms of Proxy (once received) or submit 
their proxy by electronic means or, if applicable, complete, sign and 
return their ADS Voting Card, for both the Court Meeting and the Shire 
General Meeting, as soon as possible. 
 
   Timetable 
 
   The Scheme Document contains an expected timetable of principal events 
relating to the Scheme, which is also attached as an Appendix to this 
Announcement. 
 
   Subject to approval at the relevant meetings, the satisfaction or waiver 
of the other Conditions set out in the Scheme Document and the sanction 
of the Court, the Scheme is expected to become effective on or around 
January 8, 2019. If it becomes necessary to change any of the dates 
and/or times in the expected timetable, including as a result of the 
timing of receipt of approval from the European Commission to proceed to 
completion of the Acquisition, it is intended that the Effective Date 
will be as soon as practicable after January 8, 2019. 
 
   If the Scheme is approved as outlined above, it is expected that trading 
of Shire Shares on the London Stock Exchange's main market for listed 
securities will be suspended from 4.30 p.m. on January 4, 2019. It is 
intended that, following the Scheme becoming Effective, the London Stock 
Exchange and the FCA will be requested respectively to cancel trading in 
Shire Shares on the London Stock Exchange's main market for listed 
securities and to remove the listing of the Shire Shares from the 
Official List, in each case on or shortly after the Effective Date. 
 
   The dates given are based on Shire's current expectations and may be 
subject to change. If any of the key dates set out in the timetable 
change, Shire will give notice of this change by issuing an announcement 
through a Regulatory Information Service. Such announcement will be made 
available on Shire's website at www.shire.com. 
 
   Information for Shire Shareholders and Shire ADS Holders 
 
   If you have any questions in relation to this Announcement, the Scheme 
Document, the Court Meeting or the Shire General Meeting, or are in any 
doubt as to how to complete the Forms of Proxy or lodge a Form of 
Election, please call Equiniti between 8.30 a.m. and 5.30 p.m. (London 
time) Monday to Friday (except public holidays in England and Wales) on 
0330 123 5506 (if calling from within the UK) or +44 (0)121 415 0856 (if 
calling from outside the UK). Calls are charged at the standard 
geographic rate and will vary by provider. Calls outside the United 
Kingdom will be charged at the applicable international rate. Different 
charges may apply to calls from mobile telephones. 
 
   The helpline for Shire ADS Holders is provided by the Shire Depositary 
and is available between 8.30 a.m. and 6.00 p.m. (New York time) Monday 
to Friday (except public holidays in the US) on +1 866 395 6421 from 
within the US or +1 781 575 4555 if calling from outside the US. Calls 
are charged at the standard geographic rate and will vary by provider. 
Calls outside the US will be charged at the applicable international 
rate. 
 
   Please note that calls may be monitored or recorded and Equiniti and the 
Shire Depositary cannot provide legal, tax or financial advice or advice 
on the merits of the Scheme. 
 
   Enquiries: 
 
 
 
 
Shire                                                      Citigroup Global Markets Limited 
 Christoph Brackmann (Investor Relations)                   (joint financial adviser to Shire) 
 christoph.brackmann@shire.com                              (US) Chris Hite 
 +41 41 288 41 29                                           +1 212 816 6000 
 Scott Burrows (Investor Relations)                         Cary Kochman 
 scott.burrows@shire.com                                    (UK) Jan Skarbek 
 +41 41 288 41 95                                           Andrew Seaton (Corporate Broking) 
 Sun Kim (Investor Relations)                               +44 207 986 4000 
 sun.kim@shire.com 
 +1 617 588 8175 
 Katie Joyce (Media) 
 kjoyce@shire.com 
 +1 781 482 2779 
Goldman Sachs International                                Morgan Stanley & Co. International plc 
 (joint financial adviser to Shire)                         (joint financial adviser to Shire) 
 Anthony Gutman                                             Clint Gartin 
 Robert King                                                Philippe Gallone 
 Nick Harper                                                David Kitterick 
 +44 207 774 1000                                           Peter Moorhouse (Corporate Broking) 
                                                            +44 207 425 8000 
FTI Consulting 
 (communications support to Shire) 
 Ben Atwell 
 Brett Pollard 
 +44 (0) 203 727 1000 
Takeda                                                     Evercore 
 Elissa Johnsen (Media -- outside of Japan)                 (joint financial adviser to Takeda) 
 elissa.johnsen@takeda.com                                  (US) Will Hiltz 
 +1 224 554 3185                                            John Honts 
 Kazumi Kobayashi (Media -- within Japan)                   +1 212 857 3100 
 Kazumi.kobayashi@takeda.com                                (UK) Julian Oakley 
 +81 3 3278 2095                                            +44 207 653 6000 
 Tsuyoshi Tada (Media -- within Japan) 
 tsuyoshi.tada@takeda.com 
 +81 3 3278 2417 
 Takashi Okubo (Investor Relations) 
 takeda.ir.contact@takeda.com 
 +81 3 3278 2306 
J.P. Morgan Cazenove                                       Nomura 
 (joint financial adviser to Takeda)                        (joint financial adviser to Takeda) 
 Michele Colocci                                            Akira Kiyota 
 Dwayne Lysaght                                             Paolo Cicchine 
 James Mitford                                              Andrew McNaught 
 James Robinson                                             Oliver Tucker 
 +44 207 742 4000                                           +44 207 102 1000 
Finsbury 
 (communications support to Takeda) 
 (UK) James Murgatroyd / Rollo Head / Anjali Unnikrishnan 
 +44 207 251 3801 
 (US) Kal Goldberg / Chris Ryall 
 +1 646 805 2000 
 
 
   Slaughter and May, Davis Polk & Wardwell LLP, Nagashima Ohno & 
Tsunematsu and Mourant Ozannes are retained as legal advisers to Shire. 
Linklaters LLP, Nishimura & Asahi and Ogier are retained as legal 
advisers to Takeda. 
 
   Important Notices About Financial Advisers 
 
   Evercore Partners International LLP ("Evercore"), which is authorised 
and regulated in the United Kingdom by the Financial Conduct Authority, 
is acting as financial adviser exclusively to Takeda and no one else in 
connection with the Acquisition and this Announcement and will not 
regard any other person as its client in relation to the Acquisition or 
this Announcement and shall not be responsible to anyone other than 
Takeda for providing the protections afforded to clients of Evercore, or 
for providing advice in connection with the Acquisition, this 
Announcement or any matter referred to herein. Neither Evercore nor any 
of its subsidiaries, branches or affiliates owes or accepts any duty, 
liability or responsibility whatsoever (whether direct or indirect, 
whether in contract, in tort, under statute or otherwise) to any person 
who is not a client of Evercore in connection with the Acquisition, this 
Announcement or any matter referred to herein. 
 
   JPMorgan Securities Japan Co., Ltd., together with its affiliate J.P. 
Morgan Securities plc (which conducts its UK investment banking business 
as J.P. Morgan Cazenove and which is authorised in the United Kingdom by 
the Prudential Regulation Authority and regulated in the United Kingdom 
by the Prudential Regulation Authority and the Financial Conduct 
Authority) ("J.P. Morgan"), is acting as financial adviser exclusively 
to Takeda and no one else in connection with the Acquisition and will 
not regard any other person as its client in relation to the Acquisition 
and shall not be responsible to anyone other than Takeda for providing 
the protections afforded to clients of J.P. Morgan, or for providing 
advice in connection with the Acquisition or any matter referred to 
herein. 
 
   Nomura International plc ("Nomura"), which is authorised by the 
Prudential Regulation Authority and regulated by the Prudential 
Regulation Authority and the Financial Conduct Authority in the United 
Kingdom, is acting as financial adviser exclusively to Takeda and no one 
else in connection with the Acquisition and this Announcement and Nomura, 
its affiliates and its respective officers, employees, agents, 
representatives and/or associates will not regard any other person as 
their client, nor will they be responsible to anyone other than Takeda 
for providing the protections afforded to clients of Nomura or for 
giving advice in relation to the Acquisition, this Announcement or any 
matter or  referred to herein. Neither Nomura nor any of its 
subsidiaries, branches or affiliates owes or accepts any duty, liability 
or responsibility whatsoever (whether direct or indirect, whether in 
contract, in tort, under statute or otherwise) to any person who is not 
a client of Nomura in connection with the Acquisition, this Announcement 
or any matter referred to herein. 
 
   Citigroup Global Markets Limited ("Citi"), which is authorised by the 
Prudential Regulation Authority and regulated by the Financial Conduct 
Authority and the Prudential Regulation Authority in the United Kingdom, 
is acting exclusively as financial adviser to Shire and no one else in 
connection with the Acquisition, this Announcement and the matters 
described herein, and shall not be responsible to anyone other than 
Shire for providing the protections afforded to clients of Citi, or for 
providing advice in connection with the Acquisition, this Announcement 
or any matter referred to herein. Neither Citi nor any of its 
subsidiaries, branches or affiliates owes or accepts any duty, liability 
or responsibility whatsoever (whether direct or indirect, whether in 
contract, in tort, under statute or otherwise) to any person who is not 
a client of Citi in connection with the Acquisition, this Announcement 
or any matter referred to herein. 
 
   Goldman Sachs International ("Goldman Sachs"), which is authorised by 
the Prudential Regulation Authority and regulated by the Financial 
Conduct Authority and the Prudential Regulation Authority in the United 
Kingdom, is acting exclusively as financial adviser to Shire and no one 
else in connection with the Acquisition, this Announcement and the 
matters described herein, and shall not be responsible to anyone other 
than Shire for providing the protections afforded to clients of Goldman 
Sachs or for providing advice in connection with the Acquisition, this 
Announcement or any matter referred to herein. Neither Goldman Sachs nor 
any of its subsidiaries, branches or affiliates owes or accepts any duty, 
liability or responsibility whatsoever (whether direct or indirect, 
whether in contract, in tort, under statute or otherwise) to any person 
who is not a client of Goldman Sachs in connection with the Acquisition, 
this Announcement or any matter referred to herein 
 
   Morgan Stanley & Co. International plc ("Morgan Stanley"), which is 
authorised by the Prudential Regulation Authority and regulated by the 
Financial Conduct Authority and the Prudential Regulation Authority in 
the United Kingdom, is acting exclusively as financial adviser to Shire 
and no one else in connection with the Acquisition, this Announcement 
and the matters described herein, and shall not be responsible to anyone 
other than Shire for providing the protections afforded to clients of 
Morgan Stanley or for providing advice in connection with the 
Acquisition, this Announcement or any matter referred to herein. Neither 
Morgan Stanley nor any of its subsidiaries, branches or affiliates owes 
or accepts any duty, liability or responsibility whatsoever (whether 
direct or indirect, whether in contract, in tort, under statute or 
otherwise) to any person who is not a client of Morgan Stanley in 
connection with the Acquisition, this Announcement or any matter 
referred to herein. 
 
   Further Information 
 
   This Announcement is provided for information purposes only. It is not 
intended to and does not constitute, or form part of, an offer, 
invitation or the solicitation of an offer to purchase, otherwise 
acquire, subscribe for, exchange, sell or otherwise dispose of any 
securities, or the solicitation of any vote or approval in any 
jurisdiction, pursuant to the Acquisition or otherwise nor will there be 
any sale, issuance, exchange or transfer of securities of Shire or 
Takeda pursuant to the Acquisition or otherwise in any jurisdiction in 
contravention of applicable law. 
 
   The Acquisition will be subject to Jersey laws and to the applicable 
requirements of the Takeover Code, the Panel, the Listing Rules, the 
London Stock Exchange, the Financial Conduct Authority and the UKLA. 
 
   The Acquisition will be implemented solely pursuant to the terms of the 
Scheme Document (or, in the event that the Acquisition is to be 
implemented by means of a Takeover Offer, the Offer Document), which 
will contain the full terms and conditions of the Acquisition including 
details of how to vote in respect of the Acquisition. Any decision in 
respect of the Scheme or other response in relation to the Acquisition 
by Shire Shareholders should be made only on the basis of the 
information contained in the Scheme Document. Shire Shareholders are 
advised to read the Scheme Document (including the related Forms of 
Proxy and forms of election) carefully once these become available 
because they will contain important information in relation to the 
Acquisition, the New Takeda Shares and the Combined Group. 
 
   The New Takeda Securities are not being offered to the public by means 
of this Announcement. 
 
   This Announcement does not constitute a prospectus or prospectus 
equivalent document. 
 
   Takeda reserves the right to elect (with the consent of the Panel and 
subject to the terms of the Co-operation Agreement) to implement the 
acquisition of the Shire Shares by way of a Takeover Offer as an 
alternative to the Scheme. In such event, the Takeover Offer will be 
implemented on substantially the same terms, so far as applicable, as 
those which would apply to the Scheme, subject to appropriate amendments 
to reflect the terms of the Co-operation Agreement and, among other 
things, the change in structure by which the Acquisition is to be 
implemented and compliance with all applicable laws, including US 
securities laws. 
 
   Restricted Jurisdictions 
 
   The release, publication or distribution of this Announcement in 
jurisdictions other than the United Kingdom and Jersey may be restricted 
by law and therefore any persons into whose possession this Announcement 
comes who are subject to the laws of any jurisdiction other than the 
United Kingdom and Jersey should inform themselves about, and observe, 
any applicable requirements. In particular, the ability of persons who 
are not resident in the United Kingdom or Jersey to vote their Shire 
Shares with respect to the Scheme at the Court Meeting, to execute and 
deliver forms of proxy appointing another to vote at the Court Meeting 
on their behalf or to hold or vote Takeda Shares may be affected by the 
laws of the relevant jurisdiction in which they are located. Any failure 
to comply with such requirements may constitute a violation of the 
securities laws of any such jurisdiction. To the fullest extent 
permitted by applicable law, the companies and other persons involved in 
the Acquisition disclaim any responsibility or liability for any 
violation of such restrictions by any person. 
 
   This Announcement has been prepared for the purpose of complying with 
Jersey law, the Takeover Code, the Market Abuse Regulation and the 
Disclosure and Transparency Rules and the information disclosed may not 
be the same as that which would have been disclosed if this Announcement 
had been prepared in accordance with the laws and regulations of 
jurisdictions outside Jersey. 
 
   Unless otherwise determined by Takeda or required by the Takeover Code, 
and permitted by applicable law and regulation, the Acquisition will not 
be made available, directly or indirectly, in, into or from a Restricted 
Jurisdiction where to do so would violate the laws in that jurisdiction. 
No person may vote in favour of the Acquisition by any use, means, 
instrumentality or form, and the Acquisition will not be capable of 
acceptance, from or within a Restricted Jurisdiction, if to do so would 
constitute a violation of the laws of that jurisdiction. Accordingly, 
copies of this Announcement and any formal documentation relating to the 
Acquisition are not being, and must not be, directly or indirectly, 
mailed, transmitted or otherwise forwarded, distributed or sent in, into 
or from a Restricted Jurisdiction, where to do so would violate the laws 
in that jurisdiction, and persons receiving this Announcement and all 
documents relating to the Acquisition (including custodians, nominees 
and trustees) must not mail or otherwise distribute or send them in, 
into or from Restricted Jurisdictions, where to do so would violate the 
laws in that jurisdiction. If the Acquisition is implemented by way of a 
Takeover Offer (unless otherwise permitted by applicable law and 
regulation) the Takeover Offer may not be made directly or indirectly, 
in or into, or by the use of mails or any means or instrumentality 
(including but not limited to, facsimile, e-mail or other electronic 
transmission, telex or telephone) of interstate or foreign commerce of, 
or of any facility of a national, state or other securities exchange of 
any Restricted Jurisdiction and the Takeover Offer may not be capable of 
acceptance by any such use, means, instrumentality or facilities. 
 
   The availability of the New Takeda Securities under the Acquisition to 
Shire Shareholders who are not resident in the United Kingdom or Jersey, 
or the ability of those persons to continue to hold such securities, may 
be affected by the laws or regulatory requirements of the relevant 
jurisdiction in which they are resident. Persons into whose possession 
this Announcement comes who are not resident in the United Kingdom 
should inform themselves of, and observe, any applicable requirements. 
Shire Shareholders who are in any doubt regarding such matters should 
consult an appropriate independent financial adviser in their relevant 
jurisdiction without delay. Any failure to comply with such restrictions 
may constitute a violation of the securities laws of any such 
jurisdiction. 
 
   The New Takeda Securities may not be offered, sold or delivered, 
directly or indirectly, in, into or from any Restricted Jurisdiction or 
to, or for the account or benefit of, any Restricted Overseas Persons 
except pursuant to an applicable exemption from, or in a transaction not 
subject to, applicable securities laws of those jurisdictions, or 
otherwise permitted under applicable securities laws of those 
jurisdictions. 
 
   Further details in relation to Shire Shareholders who are resident in, 
ordinarily resident in, or citizens of, jurisdictions outside the United 
Kingdom and Jersey will be contained in the Scheme Document. 
 
   Additional information for US investors 
 
   Notice to US investors in Shire: the Acquisition relates to the shares 
of a Jersey company and is being made by means of a scheme of 
arrangement provided for under the Jersey Companies Law. A transaction 
effected by means of a scheme of arrangement is not subject to the 
tender offer rules or the proxy solicitation rules under the US Exchange 
Act, and it is expected that any New Takeda Securities to be issued 
pursuant to the Scheme to Shire Shareholders would be issued in reliance 
upon the exemption from the registration requirements under the US 
Securities Act provided by Section 3(a)(10) thereof. Under applicable US 
securities laws, persons (whether or not US persons) who are or will be 
"affiliates" (within the meaning of Rule 144 of the US Securities Act) 
of Takeda prior to, or after, the Effective Date will be subject to 
certain transfer restrictions relating to the New Takeda Securities 
received in connection with the Acquisition. Accordingly, the 
Acquisition is subject to the disclosure requirements and practices 
applicable in the United Kingdom and Jersey to schemes of arrangement 
which differ from the disclosure requirements of United States tender 
offer and proxy solicitation rules and the US Securities Act. If, in the 
future, Takeda exercises the right to implement the Acquisition by way 
of a Takeover Offer and determines to extend the offer into the United 
States, the Acquisition will be made in compliance with applicable 
United States laws and regulations, including any applicable exemptions 
under the US Exchange Act. Financial information included in this 
Announcement and the Scheme Document has been or will have been prepared 
in accordance with accounting standards applicable in the United Kingdom 
and Jersey that may not be comparable to financial information of US 
companies or companies whose financial statements are prepared in 
accordance with US GAAP. 
 
   The receipt of consideration by a US holder for the transfer of its 
Shire Shares pursuant to the Scheme will be a taxable transaction for 
United States federal income tax purposes. Each Shire Shareholder is 
urged to consult his independent professional adviser immediately 
regarding the tax consequences of the Acquisition applicable to him, 
including under applicable United States state and local, as well as 
foreign and other, tax laws. 
 
   It may be difficult for US holders of Shire Shares to enforce their 
rights and any claim arising out of the US federal laws, since Takeda 
and Shire are located primarily in a non-US jurisdiction, and some or 
all of their officers and directors may be residents of a non-US 
jurisdiction. US holders of Shire Shares may not be able to sue a non-US 
company or its officers or directors in a non-US court for violations of 
the US securities laws. Further, it may be difficult to compel a non-US 
company and its affiliates to subject themselves to the jurisdiction and 
judgment of a US court. 
 
   New Takeda Securities issued pursuant to the Scheme will not be 
registered under any US state securities laws and may only be issued to 
persons resident in a state pursuant to an exemption from the 
registration requirements of the securities laws of such state. 
 
   For the purpose of qualifying for the exemption provided by Section 
3(a)(10) of the US Securities Act, Shire will advise the Court that its 
sanctioning of the Scheme will be relied on by Takeda as an approval of 
the Scheme following a hearing on its fairness to Shire Shareholders, at 
which Court hearing all Shire Shareholders are entitled to attend in 
person or through counsel to support or oppose the sanctioning of the 
Scheme and with respect to which notification will be given to all such 
holders. 
 
   Forward Looking Statements 
 
   This Announcement contains certain statements about Takeda and Shire 
that are or may be forward looking statements, including with respect to 
a possible combination involving Takeda and Shire. All statements other 
than statements of historical facts included in this Announcement may be 
forward looking statements. Without limitation, forward looking 
statements often include words such as "targets", "plans", "believes", 
"hopes", "continues", "expects", "aims", "intends", "will", "may", 
"should", "would", "could", "anticipates", "estimates", "projects" or 
words or terms of similar substance or the negative thereof.  By their 
nature, forward-looking statements involve risk and uncertainty, because 
they relate to events and depend on circumstances that will occur in the 
future and the factors described in the context of such forward-looking 
statements in this Announcement could cause actual results and 
developments to differ materially from those expressed in or implied by 
such forward-looking statements.  Such risks and uncertainties include, 
but are not limited to, the possibility that a possible combination will 
not be pursued or consummated, failure to obtain necessary regulatory 
approvals or to satisfy any of the other conditions to the possible 
combination if it is pursued, adverse effects on the market price of 
Takeda's or Shire's ordinary shares and on Takeda's or Shire's operating 
results because of a failure to complete the possible combination, 
failure to realise the expected benefits of the possible combination, 
negative effects relating to the announcement of the possible 
combination or any further announcements relating to the possible 
combination or the consummation of the possible combination on the 
market price of Takeda's or Shire's ordinary shares, significant 
transaction costs and/or unknown liabilities, general economic and 
business conditions that affect the combined companies following the 
consummation of the possible combination, changes in global, political, 
economic, business, competitive, market and regulatory forces, future 
exchange and interest rates, changes in tax laws, regulations, rates and 
policies, future business combinations or disposals and competitive 
developments.  Although it is believed that the expectations reflected 
in such forward-looking statements are reasonable, no assurance can be 
given that such expectations will prove to have been correct and you are 
therefore cautioned not to place undue reliance on these forward-looking 
statements which speak only as at the date of this Announcement. 
 
   Additional risk factors that may affect future results are contained in 
Shire's most recent Annual Report on Form 10-K and in Shire's subsequent 
Quarterly Reports on Form 10-Q, in each case including those risks 
outlined in 'ITEM1A: Risk Factors', and in Shire's subsequent reports on 
Form 8-K and other Securities and Exchange Commission filings (available 
at www.shire.com and www.sec.gov), the contents of which are not 
incorporated by reference into, nor do they form part of, this 
Announcement. These risk factors expressly qualify all forward-looking 
statements contained in this Announcement and should also be considered 
by the reader. 
 
   All forward-looking statements attributable to Takeda or Shire or any 
person acting on either company's behalf are expressly qualified in 
their entirety by this cautionary statement. Readers are cautioned not 
to place undue reliance on these forward-looking statements that speak 
only as of the date hereof. Except to the extent otherwise required by 
applicable law, neither Takeda nor Shire undertake any obligation to 
update or revise forward-looking statements, whether as a result of new 
information, future events or otherwise. 
 
   No profit forecasts or estimates 
 
   Unless expressly stated otherwise, nothing in this Announcement 
(including any statement of estimated synergies) is intended as a profit 
forecast or estimate for any period and no statement in this 
Announcement should be interpreted to mean that earnings or earnings per 
share or dividend per share for Takeda or Shire, as appropriate, for the 
current or future financial years would necessarily match or exceed the 
historical published earnings or earnings per share or dividend per 
share for Takeda or Shire, as appropriate. 
 
   Disclosure requirements of the Takeover Code 
 
   Under Rule 8.3(a) of the Takeover Code, any person who is interested in 
1 per cent. or more of any class of relevant securities of an offeree 
company or of any securities exchange offeror (being any offeror other 
than an offeror in respect of which it has been announced that its offer 
is, or is likely to be, solely in cash) must make an Opening Position 
Disclosure following the commencement of the Offer Period and, if later, 
following the announcement in which any securities exchange offeror is 
first identified. An Opening Position Disclosure must contain details of 
the person's interests and short positions in, and rights to subscribe 
for, any relevant securities of each of (i) the offeree company and (ii) 
any securities exchange offeror(s). An Opening Position Disclosure by a 
person to whom Rule 8.3(a) applies must be made by no later than 3.30 pm 
(London time) on the 10(th) business day following the commencement of 
the Offer Period and, if appropriate, by no later than 3.30 pm (London 
time) on the 10(th) business day following the announcement in which any 
securities exchange offeror is first identified. Relevant persons who 
deal in the relevant securities of the offeree company or of a 
securities exchange offeror prior to the deadline for making an Opening 
Position Disclosure must instead make a Dealing Disclosure. 
 
   Under Rule 8.3(b) of the Takeover Code, any person who is, or becomes, 
interested in 1 per cent. or more of any class of relevant securities of 
the offeree company or of any securities exchange offeror must make a 
Dealing Disclosure if the person deals in any relevant securities of the 
offeree company or of any securities exchange offeror. A Dealing 
Disclosure must contain details of the dealing concerned and of the 
person's interests and short positions in, and rights to subscribe for, 
any relevant securities of each of (i) the offeree company and (ii) any 
securities exchange offeror, save to the extent that these details have 
previously been disclosed under Rule 8. A Dealing Disclosure by a person 
to whom Rule 8.3(b) applies must be made by no later than 3.30 pm 
(London time) on the business day following the date of the relevant 
dealing. 
 
   If two or more persons act together pursuant to an agreement or 
understanding, whether formal or informal, to acquire or control an 
interest in relevant securities of an offeree company or a securities 
exchange offeror, they will be deemed to be a single person for the 
purpose of Rule 8.3. 
 
   Opening Position Disclosures must also be made by the offeree company 
and by any offeror and Dealing Disclosures must also be made by the 
offeree company, by any offeror and by any persons acting in concert 
with any of them (see Rules 8.1, 8.2 and 8.4). 
 
   Details of the offeree and offeror companies in respect of whose 
relevant securities Opening Position Disclosures and Dealing Disclosures 
must be made can be found in the Disclosure Table on the Panel's website 
at http://www.thetakeoverpanel.org.uk, including details of the number 
of relevant securities in issue, when the Offer Period commenced and 
when any offeror was first identified. If you are in any doubt as to 
whether you are required to make an Opening Position Disclosure or a 
Dealing Disclosure, you should contact the Panel's Market Surveillance 
Unit on +44 (0)20 7638 0129. 
 
   Electronic Communications 
 
   Please be aware that addresses, electronic addresses and certain other 
information provided by Shire Shareholders, persons with information 
rights and other relevant persons in connection with the receipt of 
communications from Shire may be provided to Takeda during the Offer 
Period as required under Section 4 of Appendix 4 of the Takeover Code to 
comply with Rule 2.11 of the Takeover Code. 
 
   Publication on Website and Availability of Hard Copies 
 
   A copy of this Announcement and the documents required to be published 
by Rule 26 of the Takeover Code will be made available (subject to 
certain restrictions relating to persons resident in Restricted 
Jurisdictions) on Takeda's and Shire's websites at 
www.takeda.com/investors/offer-for-shire and www.shire.com respectively 
by no later than 12 noon (London time) on November 13, 2018, the 
Business Day following this Announcement. For the avoidance of doubt, 
the contents of these websites are not incorporated into and do not form 
part of this Announcement. 
 
   Shire Shareholders may request a hard copy of this Announcement by: (i) 
contacting Souheil Salah during business hours on +44 (0) 203 5490660 
(lines are open from 9am to 5pm (London time), Monday to Friday 
(excluding public holidays in England and Wales), or (ii) by submitting 
a request by post to Souheil Salah, One Kingdom Street, 9th Floor, 
Paddington, London W2 6BD, UK. If you have received this Announcement in 
electronic form, copies of this Announcement and any document or 
information incorporated by reference into this document will not be 
provided unless such a request is made. Shire Shareholders may also 
request that all future documents, announcements and information to be 
sent to them in relation to the Acquisition should be in hard copy form. 
 
   If you are in any doubt about the contents of this Announcement or the 
action you should take, you are recommended to seek your own independent 
financial advice immediately from your stockbroker, bank manager, 
solicitor, accountant or independent financial adviser duly authorised 
under Financial Services (Jersey) Law 1998  (as amended) if you are 
resident in Jersey, the Financial Services and Markets Act 2000 (as 
amended) if you are resident in the United Kingdom, or, if not, from 
another appropriately authorised independent financial adviser. 
 
   Rounding 
 
   Certain figures included in this Announcement have been subjected to 
rounding adjustments. Accordingly, figures shown for the same category 
presented in different tables may vary slightly and figures shown as 
totals in certain tables may not be an arithmetic aggregation of the 
figures that precede them. 
 
   SHIRE LEI: 54930005LQRLI2UXRQ59 
 
 
 
   Appendix 
 
   EXEPECTED TIMETABLE OF PRINCIPAL EVENTS 
 
   All times shown are London times unless otherwise stated. All dates and 
times are indicative only, are based on Shire's and Takeda's current 
expectations and are subject to change (including as a result of changes 
to Court times). If any of the dates and/or times in this expected 
timetable change, the revised dates and/or times will be notified to 
Shire Shareholders and Shire ADS Holders by announcement through a 
Regulatory Information Service, which Shire will furnish to the SEC on 
Form 8-K. 
 
 
 
 
Event                                                         Time and/or date 
                                                              -------------------------------------------------- 
ADS Voting Record Time                                             5.00 p.m. (New York time) on November 7, 2018 
Latest time for receipt of ADS Voting Cards (or valid         10.00 a.m. (New York time) on November 29, 2018(1) 
 telephone or internet voting instructions) for the 
 Court Meeting and the Shire General Meeting 
Latest time for receipt of Forms of Proxy for: 
                                                                               11.15 a.m. on December 3, 2018(2) 
 1.    Court Meeting (BLUE form) 
                                                                               11.30 a.m. on December 3, 2018(3) 
 1.    Shire General Meeting (YELLOW form) 
Voting Record Time                                                              6.30 p.m. on December 3, 2018(4) 
Takeda Extraordinary General Meeting                                 10.00 a.m. (Tokyo time) on December 5, 2018 
Court Meeting                                                                  11.15 a.m. on December 5, 2018(5) 
Shire General Meeting                                                       11.30 a.m. on December 5, 2018(5)(6) 
The following dates are indicative only and subject 
 to change; please see note (7) below: 
Last time for Shire ADS Holders to present their Shire            5.00 p.m. (New York time) on December 26, 2018 
 ADSs for cancellation and take delivery of Shire Shares 
 to become Shire Shareholders before the Scheme Record 
 Time 
Latest time for receipt of Forms of Election                                        6.00 p.m. on January 2, 2019 
Court Sanction Hearing                                                             10.00 a.m. on January 3, 2019 
Last time for dealings in Shire Shares on the London                                4.30 p.m. on January 4, 2019 
 Stock Exchange 
Latest time for receipt of TTE Instructions and disablement                         6.00 p.m. on January 4, 2019 
 of Shire Shares in CREST 
Scheme Record Time                                                                  6.00 p.m. on January 4, 2019 
Last time for dealings in Shire ADSs on NASDAQ                   close of business (New York time) on January 4, 
                                                                                                            2019 
Suspension of dealings in Shire Shares on the London                  before open of business on January 7, 2019 
 Stock Exchange 
Halt of dealings in Shire ADSs on NASDAQ                      before open of business (New York time) on January 
                                                                                                         7, 2019 
Commencement of "when issued" dealings in the New                   9.30 a.m. (New York time) on January 7, 2019 
 Takeda ADSs on the New York Stock Exchange 
Effective Date of the Scheme                                                                     January 8, 2019 
Effective date of the issue of the New Takeda Shares                                             January 8, 2019 
Cancellation of listing of Shire Shares on the premium                              8.00 a.m. on January 9, 2019 
 listing segment of the Official List and the main 
 market of the London Stock Exchange 
Delisting of Shire ADSs                                          by 9.30 a.m. (New York time) on January 9, 2019 
Settlement Account credited with New Takeda Shares                        by 00.01 a.m. (9.01 a.m. (Tokyo time)) 
                                                                                             on January 10, 2019 
New Takeda Shares transferred from the Settlement              from January 10, 2019, but in any event not later 
 Account to JASDEC Accounts of former Shire Shareholders       than 14 calendar days after the Effective Date(8) 
Listing of, and commencement of dealings in, the New                                            January 10, 2019 
 Takeda Shares on the Tokyo Stock Exchange and the 
 Local Japanese Stock Exchanges 
New Takeda Shares transferred from the Settlement                                               January 10, 2019 
 Account to the Takeda Depositary's JASDEC Account 
New Takeda ADSs and CDIs representing New Takeda ADSs          from January 10, 2019, but in any event not later 
 delivered to former Shire Shareholders                        than 14 calendar days after the Effective Date(9) 
New Takeda ADSs delivered to former Shire ADS Holders                                  from January 10, 2019(10) 
Listing of, and commencement of regular-way dealings                 by 9.30 a.m. (New York time) on January 11, 
 in, New Takeda ADSs on the New York Stock Exchange                                                     2019(11) 
CREST accounts of former Shire Shareholders credited           within 14 calendar days of the Effective Date(12) 
 with cash due under the Scheme and in relation to 
 fractional entitlements 
Processing of electronic BACs transfers to former                  within 14 calendar days of the Effective Date 
 Shire Shareholders in respect of cash due under the 
 Scheme and in relation to fractional entitlements 
Despatch of cheques to former Shire Shareholders for               within 14 calendar days of the Effective Date 
 the cash due under the Scheme and in relation to fractional 
 entitlements 
Despatch of cheques to former Shire Shareholders in                within 14 calendar days of the Effective Date 
 relation to the New Takeda Shares sold under the Dealing 
 Facility 
Payment of the cash due to former Shire ADS Holders                      following receipt of funds by the Shire 
 by the Shire Depositary                                                                          Depositary(13) 
Latest date by which Scheme may become Effective                                                 May 8, 2019(14) 
 
 
   Notes: 
 
 
 
 
 (1  )  In order to validly instruct the Shire Depositary 
         as to voting at the Shire Meetings, the ADS Voting 
         Card must be received by the Shire Depositary by 10.00 
         a.m. (New York time) on November 29, 2018 for each 
         Shire Meeting or, if either Shire Meeting is adjourned, 
         such later date as may be notified by the Shire Depositary, 
         having consulted with Shire. Please see "Action to 
         be taken" on pages 5 to 18 of the Scheme Document. 
 (2  )  The BLUE Form of Proxy for the Court Meeting, if not 
         received by Equiniti by the time stated above, may 
         be handed to a representative of Equiniti, on behalf 
         of the Chairman of the Court Meeting, or to the Chairman 
         of the Court Meeting, before the start of the Court 
         Meeting. 
 (3  )  In order to be valid, the YELLOW Form of Proxy must 
         be received by Equiniti not later than 11.30 a.m. 
         on December 3, 2018 (or, if the Shire General Meeting 
         is adjourned, not later than 48 hours before the time 
         appointed for the adjourned Shire General Meeting). 
 (4  )  If either the Court Meeting or the Shire General Meeting 
         is adjourned, the Voting Record Time for the relevant 
         adjourned Shire Meeting will be 6.30 p.m. on the date 
         falling two calendar days before the date appointed 
         for such adjourned Shire Meeting and the ADS Voting 
         Record Time for the relevant adjourned Shire Meeting 
         will be such later date as may be notified by the 
         Shire Depositary, having consulted with Shire. 
 (5  )  In the event that the Takeda Extraordinary General 
         Meeting is postponed or adjourned, the Court Meeting 
         and Shire General Meeting will be adjourned so that 
         they will take place on the same date as the Takeda 
         Extraordinary General Meeting. 
 (6  )  To commence at 11.30 a.m. (London time) or as soon 
         thereafter as the Court Meeting shall have concluded 
         or been adjourned. 
 (7  )  These times and dates are indicative only and represent 
         the earliest possible dates for the relevant principal 
         events. These dates will depend, among other things, 
         on the dates upon which: (i) the Conditions are satisfied 
         or (where applicable) waived; (ii) the European Commission 
         gives its approval to proceed to completion of the 
         Acquisition (see paragraph 7 of Part I (Letter from 
         the Chairman of Shire PLC) of the Scheme Document 
         for further details); (iii) the Court sanctions the 
         Scheme; and (iv) the Court Order is delivered to the 
         Registrar of Companies. If it becomes necessary to 
         change any of the dates and/or times in the expected 
         timetable, including as a result of the timing of 
         receipt of approval from the European Commission to 
         proceed to completion of the Acquisition, it is intended 
         that the Effective Date will be as soon as practicable 
         after January 8, 2019. Shire will give adequate notice 
         of any changes by issuing an announcement through 
         a Regulatory Information Service and will furnish 
         such announcement to the SEC on Form 8-K. 
 (8  )  In order to avoid a delay in the completion of any 
         such transfer, Shire Shareholders who make a valid 
         JASDEC Election to deliver their New Takeda Shares 
         into an account with an AMI should contact their AMI 
         to confirm any necessary steps in order for the AMI 
         to record the delivery of the New Takeda Shares from 
         the Settlement Account. 
 (9  )  The date on which New Takeda ADSs will be delivered 
         to Shire Shareholders will depend on the type of ADS 
         Election made. In order to avoid a delay in receiving 
         their New Takeda ADSs, Shire Shareholders who make 
         a valid ADS Election to deliver their New Takeda ADSs 
         to their broker or other securities intermediary in 
         DTC should contact their broker or other securities 
         intermediary to request that it, or the DTC participant 
         through which it clears, inputs valid instructions 
         to receive delivery of the New Takeda ADSs free of 
         payment from the Takeda Depositary's DTC participant 
         account (account number 2504). 
(10  )  New Takeda ADSs will be delivered to the Shire Depositary 
         from January 10, 2019 (and in any event not later 
         than 14 calendar days after the Effective Date). 
         The date on which New Takeda ADSs will be delivered 
         to Shire ADS Holders will depend on the way in which 
         such Shire ADS Holders held their Shire ADSs. It is 
         expected that Shire ADS Holders holding through participants 
         in DTC will receive delivery shortly after the receipt 
         by the Shire Depositary of the New Takeda ADSs and 
         that registered Shire ADS Holders holding uncertificated 
         Shire ADSs (that is, Shire ADSs held outside of DTC 
         for which no certificates have been issued) will be 
         issued New Takeda ADSs in uncertificated form beginning 
         approximately one week thereafter (and will receive 
         a statement by post reflecting the issuance of New 
         Takeda ADSs in their name). Registered Shire ADS Holders 
         holding certificates for their Shire ADSs will only 
         receive delivery of their New Takeda ADSs after they 
         return their signed letter of transmittal and Shire 
         ADS certificate to the Shire Depositary. 
(11  )  The listing of, and commencement of regular-way dealings 
         in, New Takeda ADSs on January 11, 2019 is subject 
         to DTC having completed its allocation of New Takeda 
         ADSs to former Shire ADS Holders and the Shire Depositary 
         having made the relevant notification to the New York 
         Stock Exchange in time for the New York Stock Exchange 
         to make the relevant announcement prior to close of 
         business (New York time) on January 10, 2019. 
(12  )  Shire Shareholders who hold Shire Shares in uncertificated 
         form and receive the cash portion of the Consideration 
         in US Dollars must ensure that an active US Dollar 
         Cash Memorandum Account is in place in CREST by no 
         later than the Scheme Record Time. In the absence 
         of a US Dollar Cash Memorandum Account, the payment 
         of the cash portion of the Consideration will not 
         settle, resulting in a delay and the settlement of 
         the cash portion of the Consideration outside of CREST. 
(13  )  In the case of Shire ADS Holders who hold Shire ADSs 
         in certificated form, subject to presentation by such 
         holders of their signed letters of transmittal and 
         Shire ADS certificates to the Shire Depositary. 
(14  )  The latest date by which the Scheme may become Effective 
         may be extended by agreement in writing between Shire 
         and Takeda with the prior consent of the Panel and 
         (if required) the approval of the Court. 
 
 
   All references in this Announcement are in London time unless otherwise 
stated 
 
 
 
 

(END) Dow Jones Newswires

November 12, 2018 02:15 ET (07:15 GMT)

Copyright (c) 2018 Dow Jones & Company, Inc.
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