Integrated Biosciences Partners with Project 8p Foundation to Pioneer a New Path to Groundbreaking Treatments for Chromosomal Disorders
23 Abril 2024 - 9:45AM
Business Wire
Partnership expands Integrated Biosciences’ partnerships in
translational research and Project 8p Foundation’s footprint in
therapeutic development
Integrated Biosciences, a biotechnology company pioneering the
use of synthetic biology and machine learning to develop
next-generation therapeutics for age-related diseases, today
announced a strategic partnership with the patient-led Project 8p
Foundation to enhance the treatment landscape for chromosome 8p
duplication, deletion and inverted duplication deletion
(inv/dup/del) disorders. This partnership provides support to
enable Integrated Biosciences to characterize and correct the
dysregulation of cellular stress responses in 8p cell lines, paving
the way for the development of first-in-class, disease-modifying
treatments for 8p heroes suffering from complex, megabase-scale
rearrangements of the short arm of chromosome 8p.
“Chromosomal disorders have traditionally been ‘too hard’ to
drug due to the large number of genes affected by deletions or
duplications,” said Max Wilson, Ph.D., co-founder of Integrated
Biosciences. “However, our platform is the world’s most efficient
search engine for stress response-targeting small molecules, and we
have drug candidates that could well improve the lives of 8p
heroes.” Max Wilson, Ph.D., has been recently recognized with the
prestigious Hevolution/AFAR New Investigator Award in Aging Biology
and Geroscience Research, highlighting his innovative work on
stress response dysregulation in aging biology. This award
underscores Wilson's significant contributions to understanding and
potentially mitigating age-related diseases through advances in
synthetic biology.
“One of the emerging insights from our work at the Foundation is
that there appears to be convergent cellular stress responses that
go awry in a variety of diseases caused by genomic imbalance,” said
Ethan Perlstein, Ph.D., Director of Research at the Project 8p
Foundation. “These findings suggest that we may be able to harness
those stress responses to decrease symptoms often associated with
accelerated aging in 8p heroes. By supplying Integrated Biosciences
with unique patient-derived cell lines, translational expertise,
and valuable partnership knowhow, Project 8p Foundation
demonstrates its commitment to curing chromosomal disorders with
novel technologies that are accessible to all. As a pioneering
nonprofit biotech foundation, we believe this partnership paves a
path toward discoveries that will have applications beyond 8p
chromosome disorders.”
Integrated Biosciences has previously pioneered groundbreaking
approaches to AI-driven and anti-aging small molecule discovery, as
described in the company’s previous Nature, Nature Aging, and Cell
Systems publications. The company maintains a portfolio of
preclinical-stage assets that are drug candidates for multiple
age-related diseases. The new partnership underscores a shared
commitment to transforming the lives of those affected by 8p
chromosomal disorders, a central goal of the Project 8p Foundation.
The partnership will determine how the company’s assets can be used
to treat 8p and other genetic conditions.
About Integrated Biosciences
Integrated Biosciences is an emerging biotechnology company
pioneering novel approaches that combine synthetic biology and
AI-driven small-molecule drug discovery to produce next-generation
therapeutics targeting age-related diseases. The company was
founded in 2022 by MIT-, Harvard- and Princeton-trained scientists
Felix Wong, Ph.D., and Max Wilson, Ph.D., in 2022. Its scientific
advisors include James J. Collins, Ph.D., Termeer Professor of
Medical Engineering and Science at MIT, and Sir David W. C.
MacMillan Ph.D., winner of the 2021 Nobel Prize in Chemistry and
James S. McDonnell Distinguished University Professor of Chemistry
at Princeton. Integrated Biosciences’ investors include Root
Ventures, Mission BioCapital, Conscience VC, Reinforced Ventures,
and Polymath Capital. For more information, visit:
www.integratedbiosciences.com.
About Project 8p Foundation
Project 8p Foundation is a non-profit 501(c)(3) corporation
whose mission is to empower a unified community for chromosome 8p
heroes for a meaningful life today while accelerating treatments
for tomorrow. Project 8p is dedicated to advancing research,
raising awareness, and supporting individuals and families affected
by complex, megabase-scale rearrangements of the short arm of
chromosome 8. Through fostering collaboration and funding
innovative research, the Project 8p Foundation is committed to
finding cures and improving the lives of those impacted by these
genetic disorders. For more information, visit: project8p.org.
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