false
0001855175
0001855175
2024-06-30
2024-06-30
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): August 13, 2024
Contineum Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
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Delaware
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001-42001
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27-1467257
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(State or other jurisdiction
of incorporation)
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(Commission
File Number)
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(IRS Employer
Identification No.)
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10578 Science Center Drive, Suite 200
San Diego, California 92121
(Address of principal executive offices, including zip code)
(858) 333-5280
(Registrant’s telephone number, including area code)
N/A
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2):
☐
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Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
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☐
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Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
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☐
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Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
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☐
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Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
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Securities registered pursuant to Section 12(b) of the Act:
Title of each class
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Trading Symbol(s)
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Name of each exchange on which registered
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Class A Common Stock, par value $0.001 per share
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CTNM
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The Nasdaq Global Market LLC
(Nasdaq Global Select Market)
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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 2.02 Results of Operations and Financial Condition.
On August 13, 2024, Contineum Therapeutics, Inc. (the “Company”) issued a press release announcing, among other items, the Company’s financial results for the quarter ended June 30, 2024 and providing a corporate update. A copy of the press release is furnished herewith as Exhibit 99.1.
The information contained in this Current Report on Form 8-K under Item 2.02 (including Exhibit 99.1) hereto is being furnished and shall not be deemed to be “filed” for the purposes of Section 18 of the Securities and Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section and will not be incorporated by reference into any registration statement filed by the Company, under the Securities Act of 1933, as amended, unless specifically identified as being incorporated therein by reference.
Item 7.01 Regulation FD Disclosure.
Corporate Presentation.
On August 13, 2024, the Company provided an update to its corporate presentation by posting the presentation to the Company’s website, www.contineum-tx.com. The Company plans to use its website to disseminate future updates to its corporate presentation and does not intend to file or furnish a Form 8-K alerting investors each time the presentation is updated.
The information set forth in this Item 7.01 is being furnished pursuant to Item 7.01 and shall not be deemed “filed” for purposes of Section 18 of the Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, and it shall not be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or under the Exchange Act, whether made before or after the date hereof, except as expressly provided by specific reference in such a filing.
By filing this Current Report on Form 8-K and furnishing the information in this Item 7.01, the Company makes no admission as to the materiality of Item 7.01 in this report or the presentation available on the Company’s website. The information contained in the corporate presentation is summary information that is intended to be considered in the context of the Company’s filings with the Securities and Exchange Commission (the “SEC”) and other public announcements that the Company makes, by press release or otherwise, from time to time. The Company undertakes no duty or obligation to publicly update or revise the information contained in this Current Report on Form 8-K, although it may do so from time to time as its management believes is appropriate or as required by applicable law. Any such updating may be made through the filing of other reports or documents with the SEC, through press releases, by updating its website or through other public disclosure.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.
Exhibit
No.
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Description
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99.1
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104
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Cover Page Interactive Data File (embedded within XBRL document).
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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Dated: August 13, 2024
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Contineum Therapeutics, Inc.
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By:
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/s/ Peter Slover
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Peter Slover
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Chief Financial Officer
Principal Financial Officer and Principal Accounting Officer
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Exhibit 99.1
Contineum Therapeutics Reports Second Quarter 2024 Financial Results and Recent Business Highlights
-Strengthened Board and management with appointments of experienced biotech leaders Troy Ignelzi, Sarah Boyce, John Healy and Kristina Haeckl -
-Strong cash position of $219 million at the end of Q2 will support multiple clinical readouts -
SAN DIEGO, August 13, 2024 (Business Wire) — Contineum Therapeutics, Inc. (Nasdaq: CTNM), a clinical stage biopharmaceutical company focused on discovering and developing novel, oral small molecule therapies that target biological pathways associated with specific clinical impairments in the treatment of neuroscience, inflammation and immunology (NI&I) indications, today reported financial results for the second quarter ended June 30, 2024, and highlighted recent corporate progress.
“Our team has made great progress in the last several months with a continued focus on achieving our corporate milestones. We accelerated enrollment in our ongoing Phase 2 clinical trial of PIPE-307 for relapsed-remitting multiple sclerosis (RRMS), added top-level talent to our leadership team and Board of Directors, and significantly strengthened our balance sheet and extended our cash runway with our successful IPO,” said Carmine Stengone, Contineum’s Chief Executive Officer. “As we look towards the second half of 2024, we are focused on the initiation of our Phase 1b open-label PET trial of PIPE-791 in the fourth quarter and the continued enrollment in our Phase 2 VISTA trial of PIPE-307 for RRMS, while also expanding our precision-medicine approach to additional potentially high-value NI&I indications.”
Second Quarter 2024 and Recent Business Highlights
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Appointed Troy Ignelzi and Sarah Boyce to Board of Directors. In May and June 2024, Contineum appointed biotech veterans Troy Ignelzi and Sarah Boyce as independent members of its Board of Directors, respectively. Mr. Ignelzi brings nearly two decades of financial leadership and industry experience to Contineum’s Board and currently serves as the Chief Financial Officer at Rapport Therapeutics, Inc. (Nasdaq: RAPP), a precision neuromedicines company. Ms. Boyce, who currently serves as President and Chief Executive Officer of Avidity Biosciences, Inc. (Nasdaq: RNA), brings over 25 years of global commercial and clinical development expertise in the life sciences industry to Contineum’s Board and has a proven track record of scaling companies and successfully bringing over 20 products to market.
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Strengthened Management Team with Appointments of John Healy and Kristina Haeckl. In June 2024, Contineum expanded its management team with the appointments of John Healy as General Counsel & Corporate Secretary and Kristina Haeckl as Senior Vice President, Regulatory Affairs. Mr. Healy is a business and transactional attorney with over two decades of experience in the biotechnology industry, including as a corporate associate within top tier law firms, as a public company general counsel and as a trusted legal advisor providing a broad range of legal consulting support to the executive management teams of his private and public consulting clients. Ms. Haeckl brings over 30 years of experience in global regulatory affairs in the pharmaceutical/biotech industry with expertise working for companies through all phases of development.
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Enrollment On Track in PIPE-307 Phase 2 VISTA Clinical Trial in RRMS. During the second quarter, enrollment of patients continued in the ongoing Phase 2 VISTA clinical trial evaluating the efficacy and safety of PIPE-307, a selective inhibitor of the M1 receptor, in patients with RRMS. Enrollment in the study is on track and Contineum expects to complete enrollment of this trial in 2025.
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Published Preclinical and Clinical Results on PIPE-307 in PNAS. In August 2024, a manuscript titled “Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis” was published online in the peer-reviewed scientific journal the Proceedings of the National Academy of Sciences (PNAS). The published data provided early encouraging evidence that PIPE-307 is a potentially first-in-class, novel, small molecule, selective inhibitor of the muscarinic type 1 M1 receptor. The full manuscript is available here.
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Presented Preclinical Proof-of-Concept Results at IASP 2024. Preclinical data was presented on PIPE-791, Contineum’s LPA1 receptor antagonist, at the International Association for the Study of Pain (IASP) World Congress on Pain meeting, held August 5, 2024 through August 9, 2024, in Amsterdam. PIPE-791 was evaluated in a Cynomolgus macaque model of neuropathic pain using functional magnetic resonance imaging (fMRI) as a quantitative biomarker of stimulus-evoked pain following chronic constriction injury (CCI) of the sciatic nerve. Based on suppression of brain regions mediating pain intensity and affect, the findings support the notion that blocking LPA1 receptors with PIPE-791 leads to antinociception and highlight the potential in treating neuropathic pain. The presentation can be found here.
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Published Preclinical Results on PIPE-791 in Scientific Reports. In May 2024, a manuscript titled “Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis” was published online in the peer-reviewed scientific journal Scientific Reports. The published data shows that PIPE-791 promotes remyelination and mitigates neuroinflammation in both in vitro and in vivo models and functional remyelination in a mouse MOG-induced EAE model of inflammatory demyelination. The full manuscript is available here.
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Completed the Company’s Initial Public Offering. In April 2024, Contineum completed its initial public offering (IPO) resulting in net proceeds of $107.9 million.
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Second Quarter 2024 Financial Results
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Cash, Cash Equivalents and Marketable Securities. As of June 30, 2024, Contineum had cash, cash equivalents and marketable securities of $218.7 million, compared to $125.2 million at the end of 2023.
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Research and Development Expenses. Research and development expenses were $7.9 million for the three months ended June 30, 2024, compared to $9.5 million for the three months ended June 30, 2023. The decrease of $1.6 million for the three months ended June 30, 2024, compared to the three months ended June 30, 2023 was primarily driven by a $4.8 million decrease in consulting and manufacturing expenses which were offset by increases in expenses related to our on-going Phase 2 clinical trial for PIPE-307 for RRMS and our completed Phase 1 healthy volunteer clinical study for PIPE-791, expenses for toxicology studies for PIPE-791 and personnel related costs.
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General and Administrative Expenses. General and administrative expenses were $3.0 million for the three months ended June 30, 2024, compared to $1.6 million for the three months ended June 30, 2023. The increase of $1.4 million for the three months ended June 30, 2024, compared to the three months ended June 30, 2023 was primarily driven by $0.6 million increase in consulting expenses and $0.7 million increase in personnel costs.
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About Contineum Therapeutics
Contineum Therapeutics (Nasdaq: CTNM) is a clinical stage biopharmaceutical company focused on discovering and developing novel, oral small molecule therapies for NI&I indications with high unmet need. Contineum is focused on targeting biological pathways associated with specific clinical impairments, that Contineum believes, once modulated, may demonstrably impact the course of disease. Contineum has a pipeline of internally-developed programs to address multiple NI&I disorders. Contineum has two drug candidates in clinical trials, PIPE-791, an LPA1 receptor antagonist in clinical development for idiopathic pulmonary fibrosis and progressive multiple sclerosis (MS) and PIPE-307, a selective inhibitor of the M1 receptor, in clinical development for relapse remitting MS. PIPE-307 is being developed pursuant to a global license and development agreement between Contineum and Janssen Pharmaceutica NV, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, who has also announced plans to initiate a Phase 2 trial of PIPE-307 in depression in 2024.
Contineum is headquartered in San Diego, CA. For more information, please visit www.contineum-tx.com
Forward-Looking Statements
Certain statements contained in this press release, other than historical information, constitute forward-looking statements within the meaning of the federal securities laws. Forward-looking statements include, but are not limited to, statements regarding the Company’s clinical trial and product development plans and timelines; the indications, anticipated benefits of, and market opportunities for its drug candidates; its cash runway; and its business strategies and plans. These statements involve known and unknown risks, uncertainties and other important factors that are in some cases beyond the Company’s control and may cause its actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These risks and uncertainties, include, but are not limited to, the following: the Company is heavily dependent on the success of PIPE-791 and PIPE-307, both of which are in the early stages of clinical development, and neither of these drug candidates may progress through clinical development or receive regulatory approval; the results of earlier preclinical studies and clinical trials, including those conducted by third parties, may not be predictive of future results and unexpected adverse side effects or inadequate efficacy of the Company’s drug candidates may limit their development, regulatory approval and/or commercialization; the timing and outcome of research, development and regulatory review is uncertain; clinical studies and preclinical studies may not proceed at the time or in the manner expected, or at all; risks associated with reliance on third parties to successfully conduct clinical trials and, in the case of PIPE-307, the Company’s reliance upon Johnson & Johnson to develop PIPE-307 for depression or any other indication other than RRMS and, after completion of the VISTA trial, Johnson and Johnson’s decision, in its sole discretion, whether or not further develop PIPE-307 for RRMS; the Company has incurred significant operating expenses since inception and it expects that its operating expenses will continue to significantly increase for the foreseeable future; the Company’s license agreement with Johnson & Johnson may not result in the successful development of PIPE-307; and the Company may be unable to obtain, maintain and enforce intellectual property protection for its technology and drug candidates. Additional risks and uncertainties that could affect the Company’s business, operations and results are included under the captions, “Risk Factors” and "Management’s Discussion and Analysis of Financial Condition and Results of Operations” in its most recent filing on Form 10-Q and in other filings that it makes with the SEC from time to time. These documents are available on the Company’s website at www.contineum-tx.com under the Investor section and on the SEC’s website at www.sec.gov. Accordingly, readers should not rely upon forward-looking statements as predictions of future events. Except as required by applicable law, the Company undertakes no obligation to update publicly or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.
Company Contacts:
Peter Slover
CFO
pslover@contineum-tx.com
IR@contineum-tx.com
Contineum Therapeutics, Inc.
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Condensed Balance Sheets
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(Unaudited)
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(in thousands)
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June 30, 2024
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December 31, 2023
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Assets
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Cash, cash equivalents and marketable securities
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$ |
218,653 |
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$ |
125,190 |
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Prepaid expenses and other current assets
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1,667 |
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2,516 |
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Property and equipment, net
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801 |
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678 |
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Other long-term assets
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3 |
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1,283 |
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Operating lease right-of-use assets
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231 |
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719 |
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Total assets
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$ |
221,355 |
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$ |
130,386 |
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Liabilities, convertible preferred stock and stockholders' equity (deficit)
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Current liabilities
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$ |
3,739 |
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$ |
5,484 |
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Long-term liabilities
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113 |
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|
|
218 |
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Convertible preferred stock
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|
— |
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192,620 |
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Total stockholders' equity (deficit)
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217,503 |
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|
(67,936 |
) |
Total liabilities, convertible preferred stock and stockholders' equity (deficit)
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$ |
221,355 |
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$ |
130,386 |
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Contineum Therapeutics, Inc.
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Condensed Statement of Operations
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(Unaudited)
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(in thousands, except share and per share data)
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Three Months Ended June 30,
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Six Months Ended June 30,
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2024
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2023
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2024
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2023
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Revenue:
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License revenue
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$ |
— |
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$ |
50,000 |
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$ |
— |
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$ |
50,000 |
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Operating expenses:
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|
|
|
|
|
|
|
|
|
|
|
|
|
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Research and development
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7,901 |
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|
9,460 |
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|
15,679 |
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|
|
13,092 |
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General and administrative
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3,043 |
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1,603 |
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5,195 |
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3,086 |
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Total operating expenses
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10,944 |
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11,063 |
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20,874 |
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16,178 |
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Income (loss) from operations
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|
(10,944 |
) |
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|
38,937 |
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(20,874 |
) |
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|
33,822 |
|
Other income (expense):
|
|
|
|
|
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Interest income
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2,001 |
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679 |
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3,637 |
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|
|
1,080 |
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Interest expense
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— |
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(116 |
) |
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— |
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(208 |
) |
Change in fair value of warrant liability
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11 |
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2 |
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(107 |
) |
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2 |
|
Change in fair value of investor rights and obligations liability
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— |
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2,867 |
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|
— |
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2,867 |
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Other expense, net
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(77 |
) |
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(76 |
) |
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(82 |
) |
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(94 |
) |
Total other income
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1,935 |
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3,356 |
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3,448 |
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3,647 |
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Income (loss) before income taxes
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(9,009 |
) |
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42,293 |
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(17,426 |
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37,469 |
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Provision for income taxes
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— |
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(729 |
) |
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— |
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(729 |
) |
Net income (loss)
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$ |
(9,009 |
) |
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$ |
41,564 |
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|
$ |
(17,426 |
) |
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$ |
36,740 |
|
Other comprehensive income (loss):
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|
|
|
|
|
|
|
|
|
|
|
|
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|
Unrealized gain (loss) on marketable securities
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(69 |
) |
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|
(56 |
) |
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|
(235 |
) |
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|
11 |
|
Comprehensive income (loss)
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$ |
(9,078 |
) |
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$ |
41,508 |
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|
$ |
(17,661 |
) |
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$ |
36,751 |
|
Net income (loss) attributable to common stockholders, basic
|
|
$ |
(9,009 |
) |
|
$ |
5,869 |
|
|
$ |
(17,426 |
) |
|
$ |
5,521 |
|
Net income (loss) attributable to common stockholders, diluted
|
|
$ |
(9,009 |
) |
|
$ |
2,949 |
|
|
$ |
(17,426 |
) |
|
$ |
2,601 |
|
Net income (loss) per share, basic (a)
|
|
$ |
(0.39 |
) |
|
$ |
2.56 |
|
|
$ |
(1.35 |
) |
|
$ |
2.42 |
|
Net income (loss) per share, diluted (a)
|
|
$ |
(0.39 |
) |
|
$ |
0.84 |
|
|
$ |
(1.35 |
) |
|
$ |
0.74 |
|
Weighted-average shares of common stock outstanding, basic
|
|
|
23,355,588 |
|
|
|
2,291,866 |
|
|
|
12,862,328 |
|
|
|
2,284,750 |
|
Weighted-average shares of common stock outstanding, diluted
|
|
|
23,355,588 |
|
|
|
3,511,757 |
|
|
|
12,862,328 |
|
|
|
3,513,596 |
|
(a) Basic and diluted per share amounts are the same for Class A and Class B shares.
v3.24.2.u1
Document And Entity Information
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Jun. 30, 2024 |
Document Information [Line Items] |
|
Entity, Registrant Name |
Contineum Therapeutics, Inc.
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Document, Type |
8-K
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Document, Period End Date |
Aug. 13, 2024
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Entity, Incorporation, State or Country Code |
DE
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Entity, File Number |
001-42001
|
Entity, Tax Identification Number |
27-1467257
|
Entity, Address, Address Line One |
10578 Science Center Drive, Suite 200
|
Entity, Address, City or Town |
San Diego
|
Entity, Address, State or Province |
CA
|
Entity, Address, Postal Zip Code |
92121
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City Area Code |
858
|
Local Phone Number |
333-5280
|
Written Communications |
false
|
Soliciting Material |
false
|
Pre-commencement Tender Offer |
false
|
Pre-commencement Issuer Tender Offer |
false
|
Title of 12(b) Security |
Class A Common Stock
|
Trading Symbol |
CTNM
|
Security Exchange Name |
NASDAQ
|
Entity, Emerging Growth Company |
true
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Entity, Ex Transition Period |
false
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Amendment Flag |
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Entity, Central Index Key |
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Contineum Therapeutics (NASDAQ:CTNM)
Gráfica de Acción Histórica
De Jul 2024 a Ago 2024
Contineum Therapeutics (NASDAQ:CTNM)
Gráfica de Acción Histórica
De Ago 2023 a Ago 2024