SUPN Supernus Pharmaceuticals Inc

Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, today announced financial results for the second quarter of 2024 and associated Company developments.

Business Highlights

• Total IQVIA prescriptions for Qelbree were 184,342 in the second quarter 2024, an increase of 26% compared to the same period in the prior year.
• In August 2024, the Company resubmitted its New Drug Application (NDA) for its apomorphine infusion device (SPN-830) for the continuous treatment of motor fluctuations ("off" episodes) in Parkinson’s disease.

“In the second quarter of 2024, we delivered strong net sales growth from our key growth drivers, Qelbree and GOCOVRI, as well as strong growth in adjusted operating earnings. We also advanced our product pipeline, announcing interim results from our open-label Phase 2a clinical study of SPN-817 for treatment-resistant seizures, and continued to progress SPN-820 through two Phase 2 studies in patients with depression," said Jack Khattar, President and CEO of Supernus. “Continued growth from Qelbree and GOCOVRI, together with pipeline progress, gives us confidence in delivering on our increased guidance and our operational objectives for 2024."

Product Pipeline Update

SPN-820 – Novel first-in-class molecule that increases mTORC1 mediated synaptic function for depression

• Nearly three-quarters of the planned patients have been enrolled in the ongoing Phase IIb multi-center randomized double-blind placebo-controlled parallel design study of SPN-820 in adults with treatment-resistant depression. The study will examine the efficacy and safety of SPN-820 over a course of five weeks of treatment in approximately 268 patients in up to 50 clinical sites. The primary outcome measure is the change from baseline to end of treatment period on the Montgomery-Asberg Depression Rating Scale (MADRS) Total Score. Topline data from the Phase IIb trial are expected in the first half of 2025.
• Enrollment is ongoing in the Phase II open-label study in patients with major depressive disorder (MDD). The primary objective of the study is to assess efficacy in MDD, as well as onset of efficacy. Topline results from the study are expected by the end of 2024.

SPN-817 – Novel first-in-class highly selective AChE inhibitor for epilepsy

• In May 2024, the Company announced data from the planned interim analysis of its exploratory open-label Phase IIa clinical study of SPN-817 for treatment-resistant seizures. The interim analysis was based on 41 enrolled subjects, of which 19 completed the maintenance period. The Company continues to expect topline results for the full study in the second half of 2024.

• A Phase IIb randomized, double-blind, placebo-controlled study in patients with treatment resistant focal seizures is expected to start by the end of 2024.

SPN-443 – Novel stimulant for ADHD/CNS

• The Company plans to initiate a Phase I single dose study in healthy adults in 2024 following submission of an Investigational New Drug application. The primary objective of the study is to assess safety and tolerability.

Financial Highlights

This section includes information on non-GAAP financial measures. See “Non-GAAP Financial Information” section for information on non-GAAP financial measures. In addition, a reconciliation of applicable GAAP to non-GAAP financial information is included at the end of this press release.

Revenues

The following table provides information regarding total revenues (dollars in millions):

	Three Months Ended June 30,												Six Months Ended June 30,
		2024				2023			Change %					2024				2023			Change %
Net product sales
Qelbree	$	59.4			$	31.0				92	%		$	104.5			$	56.8				84	%
GOCOVRI		31.7				28.8				10	%			58.3				54.8				6	%
Oxtellar XR		29.5				23.8				24	%			56.5				52.7				7	%
APOKYN		17.3				17.6				(2	)%			33.9				34.8				(2	)%
Trokendi XR		17.1				19.3				(12	)%			33.1				54.1				(39	)%
Other(2)		7.5				7.8				(4	)%			14.7				15.7				(6	)%
Total net product sales		162.5				128.3				27	%			301.0				268.9				12	%
Royalty, licensing and other revenues(3)		5.8				7.2				(20	)%			11.0				20.4				(46	)%
Total revenues	$	168.3			$	135.5				24	%		$	312.0			$	289.3				8	%
Total revenues excluding Trokendi XR and Oxtellar XR net product sales (non-GAAP)(1)	$	121.7			$	92.4				32	%		$	222.4			$	182.5				22	%

• Total revenues were $168.3 million and $312.0 million for the three and six months ended June 30, 2024, compared to $135.5 million and $289.3 million in the same period in 2023.
  • Total net product sales were $162.5 million and $301.0 million for the three and six months ended June 30, 2024, compared to $128.3 million and $268.9 million in the same period in 2023, respectively. The increase in both periods was primarily due to the increase in net sales of Qelbree, GOCOVRI and Oxtellar XR, partially offset by the decline in net product sales of Trokendi XR due to generic erosion.
  • Total revenues excluding Trokendi XR and Oxtellar XR net product sales (non-GAAP) increased 32% and 22% for the three and six months ended June 30, 2024, compared to the same period in 2023.

Other Financial Highlights

• Operating earnings was $22.6 million and $19.4 million for the three and six months ended June 30, 2024, compared to operating loss of $(17.6) million and $(12.4) million for the same periods in 2023, respectively. The positive increase in both periods was primarily due to an increase in total net product sales.
• Adjusted operating earnings (non-GAAP) were $45.5 million and $67.7 million for the three and six months ended June 30, 2024, compared to $10.0 million and $40.5 million for the same periods in 2023, respectively.
• Net earnings (loss) and diluted earnings (loss) per share were $19.9 million and $0.36 for the three months and $20.0 million and $0.36 for the six months ended June 30, 2024, respectively, compared to $(0.8) million and $(0.02) for the three months and $16.1 million and $0.29 for the six months ended June 30, 2023, respectively.
• At June 30, 2024, cash, cash equivalents, and current and long-term marketable securities were approximately $347.2 million compared to $271.5 million as of December 31, 2023. This increase was primarily due to cash generated from operations.

Full Year 2024 Financial Guidance

For the full year 2024, the Company is increasing prior financial guidance for total revenues, GAAP operating earnings (loss) and non-GAAP operating earnings, and maintaining guidance for combined R&D and SG&A expenses as set forth below (dollars in millions).

	Current Guidance(as of August 6, 2024)		Previous Guidance(as of May 8, 2024)
Total revenues (includes approximately $135 - $145 million of Trokendi XR and Oxtellar XR)(4)(5)	$600 - $625		$580 - $620
Combined R&D and SG&A expenses	$430 - $460		$430 - $460
Operating earnings (loss)	$0 - $20		$(30) - $(0)
Adjusted operating earnings (non-GAAP)(1)	$100 - $125		$80 - $110

Non-GAAP Financial Information

This press release contains financial measures that present financial information which do not comply with United States generally accepted accounting principles (GAAP). The non-GAAP financial measures should be considered in addition to, not as a substitute for or in isolation from, or superior to measures prepared in accordance with GAAP. Non-GAAP adjusted operating earnings on a historical and projected basis adjusts for non-cash share-based compensation expense, depreciation and amortization, intangible asset impairment charges and changes to fair value of contingent consideration, and for factors that are unusual, non-recurring or unpredictable, and excludes those costs, expenses, and other specified items presented in the reconciliation tables in this press release. In addition to non-GAAP adjusted operating earnings, we also present total revenues excluding net product sales of Trokendi XR (GAAP) and Oxtellar XR (GAAP), which is a non-GAAP measure and is calculated as total revenues (GAAP) less net product sales of Trokendi XR (GAAP) and Oxtellar XR (GAAP). Beginning in the year a product loses exclusivity due to generic entrants we generally do not expect net product sales of such products to constitute a significant part of our revenue in the future. We believe that the use of non-GAAP financial measures provides useful supplemental information to management, investors, analysts and others regarding the Company’s revenue and results of operations and assist management, investors, analysts, and others in understanding and evaluating our revenue growth and the performance of the business.

There are limitations associated with the use of non-GAAP financial measures and therefore comparability may be limited. These limitations include: non-GAAP financial measures that may not be entirely comparable to similarly titled measures used by other companies; these may not reflect all items of income and expense, as applicable, that affect our operations; there may be potential differences among calculation methodologies; these may differ from the non-GAAP information used by other companies, including peer companies. We mitigate these limitations by reconciling the non-GAAP financial measure to the most comparable GAAP financial measure. Investors are encouraged to review the reconciliation. The Company’s 2024 financial guidance is also being provided on both a GAAP and a non-GAAP basis.

End Notes

(1) See the section titled “Non-GAAP Financial Information” for information about this non-GAAP financial measure. A reconciliation of each non-GAAP financial measure to the most directly comparable GAAP financial measure is included at the end of this press release.(2) Includes net product sales of MYOBLOC®, XADAGO® and Osmolex ER®.(3) Royalty, licensing, and other revenues include royalties on generic Trokendi XR, other licensed products and intellectual property.(4) Includes net product sales and royalty, licensing, and other revenue.(5) Reflects continued generic erosion of Trokendi XR and generic erosion of Oxtellar XR beginning in September 2024.

Conference Call Details

Supernus will host a conference call and webcast today, August 6, 2024, at 4:30 p.m. Eastern Time to discuss these results. A live webcast will be available in the Events & Presentations section of the Company’s Investor Relations website www.supernus.com/Investors.

Participants may also pre-register any time before the call here. Once registration is completed, participants will be provided a dial-in number with a personalized conference code to access the call. Please dial in 15 minutes prior to the start time.

Following the live call, a replay will be available on the Company's Investor Relations website www.supernus.com/Investors. The webcast will be available on the Company’s website for 60 days following the live call.

About Supernus Pharmaceuticals, Inc.

Supernus Pharmaceuticals is a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases.

Our diverse neuroscience portfolio includes approved treatments for epilepsy, migraine, ADHD, hypomobility in Parkinson's disease (PD), cervical dystonia, chronic sialorrhea, and dyskinesia in PD patients receiving levodopa-based therapy. We are developing a broad range of novel CNS product candidates including new potential treatments for hypomobility in PD, epilepsy, depression, and other CNS disorders.

For more information, please visit www.supernus.com.

Forward-Looking Statements

This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements do not convey historical information but relate to predicted or potential future events that are based upon management's current expectations. These statements are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. In addition to the factors mentioned in this press release, such risks and uncertainties include, but are not limited to, the Company’s ability to sustain and increase its profitability; the Company’s ability to raise sufficient capital to fully implement its corporate strategy; the implementation of the Company’s corporate strategy; the Company’s future financial performance and projected expenditures; the Company’s ability to increase the number of prescriptions written for each of its products and the products of its subsidiaries; the Company’s ability to increase its net revenue from its products and the products of its subsidiaries; the Company’s ability to commercialize its products and the products of its subsidiaries; the Company’s ability to enter into future collaborations with pharmaceutical companies and academic institutions or to obtain funding from government agencies; the Company’s product research and development activities, including the timing and progress of the Company’s clinical trials, and projected expenditures; the Company’s ability to receive, and the timing of any receipt of, regulatory approvals to develop and commercialize the Company’s product candidates; the Company’s ability to protect its intellectual property and the intellectual property of its subsidiaries and operate its business without infringing upon the intellectual property rights of others; the Company’s expectations regarding federal, state and foreign regulatory requirements; the therapeutic benefits, effectiveness and safety of the Company’s product candidates; the accuracy of the Company’s estimates of the size and characteristics of the markets that may be addressed by its product candidates; the Company’s ability to increase its manufacturing capabilities for its products and product candidates; the Company’s projected markets and growth in markets; the Company’s product formulations and patient needs and potential funding sources; the Company’s staffing needs; and other risk factors set forth from time to time in the Company’s filings with the Securities and Exchange Commission made pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended. The Company undertakes no obligation to update the information in this press release to reflect events or circumstances after the date hereof or to reflect the occurrence of anticipated or unanticipated events.

Supernus Pharmaceuticals, Inc.Condensed Consolidated Balance Sheets(in thousands, except share data)
	June 30,				December 31,
		2024				2023
	(unaudited)
Assets
Current assets
Cash and cash equivalents	$	52,089			$	75,054
Marketable securities		295,098				179,820
Accounts receivable, net		152,494				144,155
Inventories, net		68,155				77,408
Prepaid expenses and other current assets		23,166				16,676
Total current assets		591,002				493,113
Long-term marketable securities		—				16,617
Property and equipment, net		12,274				13,530
Intangible assets, net		559,644				599,889
Goodwill		117,019				117,019
Other assets		35,890				37,505
Total assets	$	1,315,829			$	1,277,673
Liabilities and stockholders’ equity
Current liabilities
Accounts payable and accrued liabilities	$	82,611			$	79,569
Accrued product returns and rebates		175,119				154,274
Contingent consideration, current portion		47,303				52,070
Other current liabilities		3,623				4,283
Total current liabilities		308,656				290,196
Contingent consideration, long-term		697				1,380
Operating lease liabilities, long-term		30,294				33,196
Deferred income tax liabilities, net		11,440				24,963
Other liabilities		7,288				6,422
Total liabilities		358,375				356,157
Stockholders’ equity
Common stock, $0.001 par value; 130,000,000 shares authorized; 55,046,049 and 54,723,356 shares issued and outstanding as of June 30, 2024 and December 31, 2023, respectively		55				55
Additional paid-in capital		455,170				439,493
Accumulated other comprehensive loss, net of tax		(372	)			(593	)
Retained earnings		502,601				482,561
Total stockholders’ equity		957,454				921,516
Total liabilities and stockholders’ equity	$	1,315,829			$	1,277,673

Supernus Pharmaceuticals, Inc.Condensed Consolidated Statements of Earnings (Loss)(in thousands, except share and per share data)
	Three Months EndedJune 30,								Six Months EndedJune 30,
		2024				2023				2024				2023
	(unaudited)								(unaudited)
Revenues
Net product sales	$	162,538			$	128,336			$	300,999			$	268,911
Royalty, licensing and other revenues		5,787				7,227				10,970				20,416
Total revenues		168,325				135,563				311,969				289,327
Costs and expenses
Cost of goods sold(a)		17,916				21,091				34,225				44,551
Research and development		26,183				24,379				51,113				45,591
Selling, general and administrative		85,904				86,782				172,420				172,379
Amortization of intangible assets		20,108				20,108				40,245				40,074
Contingent consideration expense (gain)		(4,355	)			790				(5,450	)			(857	)
Total costs and expenses		145,756				153,150				292,553				301,738
Operating earnings (loss)		22,569				(17,587	)			19,416				(12,411	)
Other income (expense)
Interest and other income, net		3,733				1,370				7,129				6,716
Interest expense		—				(910	)			—				(2,415	)
Total other income (expense)		3,733				460				7,129				4,301
Earnings (loss) before income taxes		26,302				(17,127	)			26,545				(8,110	)
Income tax expense (benefit)		6,386				(16,296	)			6,505				(24,227	)
Net earnings (loss)	$	19,916			$	(831	)		$	20,040			$	16,117
Earnings (loss) per share
Basic	$	0.36			$	(0.02	)		$	0.37			$	0.30
Diluted	$	0.36			$	(0.02	)		$	0.36			$	0.29
Weighted average shares outstanding
Basic		54,978,781				54,502,993				54,890,265				54,442,463
Diluted		55,724,283				54,502,993				55,675,474				59,035,154
(a) Excludes amortization of intangible assets.

Supernus Pharmaceuticals, Inc.Reconciliations of GAAP to Non-GAAP Financial Information(Unaudited)

Reconciliation of GAAP Total revenues to Non-GAAP Total revenues excluding Trokendi XR and Oxtellar XR net product sales

An itemized reconciliation between total revenues on a GAAP basis and Total revenues excluding Trokendi XR and Oxtellar XR net product sales, a non-GAAP measure, is as follows (dollars in millions):

	Three Months Ended June 30,												Six Months Ended June 30,
		2024				2023			Change %					2024				2023			Change %
Total revenues (GAAP)(1)	$	168.3			$	135.5				24	%		$	312.0			$	289.3				8	%
Adjustments:
Trokendi XR net product sales		(17.1	)			(19.3	)			(12	)%			(33.1	)			(54.1	)			(39	)%
Oxtellar XR net product sales		(29.5	)			(23.8	)			24	%			(56.5	)			(52.7	)			7	%
Total revenues excluding Trokendi XR and Oxtellar XR net product sales (non-GAAP)(1)	$	121.7			$	92.4				32	%		$	222.4			$	182.5				22	%
(1) Includes net product sales and royalty, licensing, and other revenues.

Reconciliation of GAAP Operating earnings (loss) to Non-GAAP Adjusted Operating earnings

An itemized reconciliation between operating earnings (loss) on a GAAP basis and adjusted operating earnings on a non-GAAP basis is as follows (dollars in millions):

	Three Months EndedJune 30,								Six Months EndedJune 30,
		2024				2023				2024				2023
Operating earnings (loss) - As Reported (GAAP)	$	22.6			$	(17.6	)		$	19.4			$	(12.4	)
Adjustments:
Amortization of intangible assets		20.1				20.1				40.2				40.1
Share-based compensation		6.6				6.1				12.4				12.4
Contingent consideration expense (gain)		(4.4	)			0.8				(5.5	)			(0.9	)
Depreciation		0.6				0.6				1.2				1.3
Operating earnings - As Adjusted (non-GAAP)	$	45.5			$	10.0			$	67.7			$	40.5

Non-GAAP adjusted operating earnings adjusts for non-cash items including amortization of intangible assets, share-based compensation expense, change in fair value of contingent consideration, and depreciation.

Reconciliation of Full Year 2024 Financial Guidance - GAAP Operating earnings (loss) to Non-GAAP Adjusted Operating earnings

An itemized reconciliation between projected operating earnings (loss) on a GAAP basis for the full year 2024 and projected adjusted operating earnings on a non-GAAP basis for the full year 2024 is as follows (dollars in millions):

	Current Guidance(as of August 6, 2024)		Previous Guidance(as of May 8, 2024)
Operating earnings (loss) - GAAP	$0 - $20		$(30) - $0
Adjustments:
Amortization of intangible assets	$78 - $80		$80 - $81
Share-based compensation	$27 - $29		$27 - $29
Contingent consideration expense (gain)	$(7) - $(7)		$1 - $2
Depreciation	$2 - $3		$2 - $3
Operating earnings - As Adjusted (non-GAAP)	$100 - $125		$80 - $110

CONTACTS:

Jack A. Khattar, President and CEOTimothy C. Dec, Senior Vice President and CFOSupernus Pharmaceuticals, Inc.(301) 838-2591

or

INVESTOR CONTACT:Peter VozzoICR Westwicke(443) 213-0505peter.vozzo@westwicke.com