UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 6-K
Report of Foreign Private Issuer
Pursuant to Rule 13a-16 or 15d-16
Under the Securities Exchange Act of 1934
For the Month of August 2023
001-36203
(Commission File Number)
CAN-FITE BIOPHARMA LTD.
(Exact name of Registrant as specified in its charter)
10 Bareket Street
Kiryat Matalon, P.O. Box 7537
Petach-Tikva 4951778, Israel
(Address of principal executive offices)
Indicate by check mark whether the registrant
files or will file annual reports under cover Form 20-F or Form 40-F.
Form 20-F ☑ Form 40-F ☐
This Report on Form 6-K, Exhibit 99.1,
Exhibit 99.2 and the text under the heading “Financial Results” and “Forward-Looking Statements” in the
press release in Exhibit 99.3 are hereby incorporated by reference into the registrant’s Registration Statements on Form
S-8 (File Nos. 333-227753 and 333-271384) and Form F-3 (File Nos.
333-195124, 333-236064, 333-249063 and 333-262055), to be a part there of from the date on which this
report is submitted, to the extent not superseded by documents or reports subsequently filed or furnished.
On August 31, 2023, Can-Fite BioPharma Ltd. (the
“Company”) issued a press release announcing financial results for the six months ended June 30, 2023 and updates on its drug
development programs. In addition, on the same day, the Company issued unaudited interim condensed consolidated financial statements as
of June 30, 2023. Attached hereto and incorporated by reference herein are the following exhibits:
Exhibit Index
SIGNATURES
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto
duly authorized.
Date: August 31, 2023 |
By: |
/s/ Motti Farbstein |
|
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Motti Farbstein |
|
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Chief Executive Officer and
Chief Financial Officer |
3
Exhibit 99.1
OPERATING AND FINANCIAL REVIEW AND PROSPECTS
You should read the following
selected financial data and discussion of our operating and financial condition and prospects in conjunction with the financial statements
and the notes thereto included elsewhere in this 6-K. Our financial statements are prepared in accordance with U.S. GAAP, and reported
in U.S. dollars. We maintain our accounting books and records in U.S. dollars and our functional currency is the U.S. dollar. Certain
amounts presented herein may not sum due to rounding. Unless the context requires otherwise, references in this report to “Can-Fite,”
the “Company,” “we,” “us” and “our” refer to Can-Fite BioPharma Ltd, an Israeli company
and our consolidated subsidiaries. “NIS” means New Israeli Shekel, and “$,” “US$,“U.S. dollars”
and “USD” mean United States dollars.
Forward Looking Statements
The following discussion contains
“forward-looking statements,” including statements regarding expectations, beliefs, intentions or strategies for the future.
These statements may identify important factors which could cause our actual results to differ materially from those indicated by the
forward-looking statements. Given these uncertainties, readers are cautioned not to place undue reliance on such forward-looking statements.
Factors that could cause our actual results to differ materially from those expressed or implied in such forward-looking statements include,
but are not limited to:
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our history of losses and needs for additional capital to fund our operations and our inability to obtain additional capital on acceptable terms, or at all; |
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uncertainties of cash flows and inability to meet working capital needs; |
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the initiation, timing, progress and results of our preclinical studies, clinical trials and other product candidate development efforts; |
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our ability to advance our product candidates into clinical trials or to successfully complete our preclinical studies or clinical trials; |
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our receipt of regulatory approvals for our product candidates, and the timing of other regulatory filings and approvals; |
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the clinical development, commercialization and market acceptance of our product candidates; |
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our ability to establish and maintain strategic partnerships and other corporate collaborations; |
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the implementation of our business model and strategic plans for our business and product candidates; |
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the scope of protection we are able to establish and maintain for intellectual property rights covering our product candidates and our ability to operate our business without infringing the intellectual property rights of others; |
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competitive companies, technologies and our industry; |
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risks related to unfavorable economic and market conditions and adverse developments with respect to financial institutions and associated liquidity risk; |
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risks related to not satisfying the continued listing requirements of NYSE American; and |
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statements as to the impact of the political and security situation in Israel on our business. |
All forward-looking statements
attributable to us or persons acting on our behalf speak only as of the date of the 6-K to which this discussion is attached and are expressly
qualified in their entirety by the cautionary statements included herein. We undertake no obligations to update or revise forward-looking
statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of unanticipated events. In
evaluating forward-looking statements, you should consider these risks and uncertainties.
Glossary of Certain Terms
As used herein, unless the
context otherwise requires:
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references to “ADSs” refer to the Registrant’s American Depositary Shares; |
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references to “A3AR” refer to the A3 adenosine receptor; |
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references to “HCC” refer to hepatocellular carcinoma, also known as primary liver cancer; |
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references to “ordinary shares,” “our shares”
and similar expressions refer to the Company’s ordinary shares, no nominal (par) value per share; and |
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references to the “SLD” are to the steatotic liver disease |
Overview
We
are a clinical-stage biopharmaceutical company that develops orally bioavailable small molecule therapeutic products for the treatment
of cancer, liver and inflammatory diseases and erectile dysfunction. We are also developing specific formulations of cannabis components
for the treatment of cancer, inflammatory, autoimmune, and metabolic diseases. Our platform technology utilizes the Gi protein associated
A3 adenosine receptor, or A3AR, as a therapeutic target. A3AR is highly expressed in pathological body cells such as inflammatory and
cancer cells, and has a low expression in normal cells, suggesting that the receptor could be a specific target for pharmacological intervention.
Our pipeline of drug candidates are synthetic, highly specific agonists and allosteric modulators targeting the A3AR.
Our
product pipeline is based on the research of Dr. Pnina Fishman, who investigated a clinical observation that tumor metastasis can be found
in most body tissues, but are rarely found in muscle tissue, which constitutes approximately 60% of human body weight. Dr. Fishman’s
research revealed that one reason that striated muscle tissue is resistant to tumor metastasis is that muscle cells release small molecules
which bind with high selectivity to the A3AR. As part of her research, Dr. Fishman also discovered that A3ARs have significant expression
in tumor and inflammatory cells, whereas normal cells have low or no expression of this receptor. The A3AR agonists and allosteric modulators,
currently our pipeline of drug candidates, bind with high selectivity and affinity to the A3ARs and upon binding to the receptor initiate
down-stream signal transduction pathways resulting in apoptosis, or programmed cell death, of tumors and inflammatory cells and to the
inhibition of inflammatory cytokines. Cytokines are proteins produced by cells that interact with cells of the immune system in order
to regulate the body’s response to disease and infection. Overproduction or inappropriate production of certain cytokines by the
body can result in disease.
Our
product candidates, CF101, CF102 and CF602, are being developed to treat cancer, liver and inflammatory diseases, as well as erectile
dysfunction. CF101, also known as Piclidenoson, is in an advance stage of clinical development for the treatment of autoimmune-inflammatory
diseases, including psoriasis. During 2021, we decided to stop developing Piclidenoson for the treatment of COVID-19 to focus on other
indications. CF102, also known as Namodenoson, is being developed for the treatment of HCC and has orphan drug designation for the treatment
of HCC in the United States and Europe. Namodenoson was granted Fast Track designation by the U.S. Food and Drug Administration, or FDA,
as a second line treatment to improve survival for patients with advanced HCC who have previously received Nexavar (sorafenib). Namodenoson
is also being developed for the treatment of SLD, a disease for which no FDA approved therapies currently exist. CF602 is our second
generation allosteric drug candidate for the treatment of erectile dysfunction, which has shown efficacy in the treatment of erectile
dysfunction in preclinical studies and we are investigating additional compounds, targeting A3AR, for the treatment of erectile dysfunction.
Preclinical studies revealed that our drug candidates have potential to treat additional inflammatory diseases, such as Crohn’s
disease, oncological diseases, viral diseases, such as the JC virus, and obesity.
We
believe our pipeline of drug candidates represent a significant market opportunity. For instance, according to iHealthcareAnalyst, the
psoriasis drug market is forecasted to be worth $11.3 billion by 2025. According to DelveInsight, the HCC drug market in the G8 countries
(U.S., Germany, France, Italy, Spain, UK, Japan and China) is expected to reach $3.8 billion by 2027.
We
have in-licensed an allosteric modulator of the A3AR, CF602 from Leiden University. In addition, we have out-licensed the following product
candidates for indications that we are currently pursuing:
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Piclidenoson for the treatment of (i) psoriasis to Cipher Pharmaceuticals, or Cipher, for Canada, (ii) psoriasis to Gebro Holding, or Gebro, for Spain, Switzerland and Austria, (iii) psoriasis to CMS Medical, or CMS, for China (including Hong Kong, Macao and Taiwan), (iv) psoriasis to Kyongbo Pharm Co. Ltd., or Kyongbo Pharm, for South Korea, (v) psoriasis to Ewopharma AG, or Ewopharma, for Central Eastern Europe, and (vi) osteoarthritis in companion animals including dogs and cats to Vetbiolix. |
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Namodenoson for the treatment of (i) liver cancer and SLD to Chong Kun Dang Pharmaceuticals, or CKD, for South Korea, (ii) advanced liver cancer and SLD to CMS for China (including Hong Kong, Macao and Taiwan), and (iii) HCC and SLD to Ewopharma, for Central Eastern Europe and Switzerland. |
Currently,
(i) we are doing the preparatory work for pivotal Phase III studies for Piclidenoson in the treatment of psoriasis following meetings
with the FDA & EMA, (ii) we are conducting a pivotal Phase III trial for Namodenoson in the treatment of advanced liver cancer which
is open for enrollment, (iii) we are conducting a Phase IIb study of Namodenoson in the treatment of SLD which is open for enrollment,
(iv) we are doing the preparatory work for Phase IIb study of Namodenoson in the treatment of pancreatic cancer, (v) we are investigating
additional compounds, targeting the A3 adenosine receptor, for the treatment of erectile dysfunction, and (vi) we are conducting pre-clinical
studies with formulations of cannabis components for the treatment of diseases in which there is an overexpression of A3AR. Since inception,
we have incurred significant losses in connection with our research and development.
Moreover,
we believe characteristics of Piclidenoson, as exhibited in our clinical studies to date, including its good safety profile, clinical
activity, simple and less frequent delivery through oral administration and its low cost of production, position it well against the competition
in psoriasis markets, where treatments, when available, often include injectable drugs, many of which can be highly toxic, expensive and
not always effective.
Like
Piclidenoson, Namodenoson has a good safety profile, is orally administered and has a low cost of goods, which we believe may position
it well in the HCC market, where no drug has yet been approved by the FDA for patients with advanced liver cancer disease defined as Child
Pugh B7. In addition, pre-clinical studies show Namodenoson’s novel mechanism of action which entails de-regulation of three key
signaling pathways which mediate the etiology and pathology of SLD and are responsible for the anti-inflammatory and anti-fibrogenic
effect in the liver. Most recently, pre-clinical data support Namodenoson’s potential utilization as an anti-obesity drug.
Nevertheless,
other drugs on the market, new drugs under development (including drugs that are in more advanced stages of development in comparison
to our drug candidates) and additional drugs that were originally intended for other purposes, but were found effective for purposes targeted
by us, may all be competitive to the current drugs in our pipeline. In fact, some of these drugs are well established and accepted among
patients and physicians in their respective markets, are orally bioavailable, can be efficiently produced and marketed, and are relatively
safe. None of our product candidates have been approved for sale or marketing and, to date, there have been no commercial sales of any
of our product candidates.
Results of Operations
Revenues
Revenues for the six months
ended June 30, 2023 were $0.39 million compared to revenues of $0.41 million during the six months ended June 30, 2022. Revenues for the
six months ended June 30, 2023 and June 30, 2022 comprised of recognition of a portion of advance payments received under distribution
agreements with Gebro, CKD, Cipher and Ewopharma.
Research and development expenses
Research and development expenses
for the six months ended June 30, 2023 were $3.41 million compared with $3.27 million for the same period in 2022. Research and development
expenses for the first half of 2023 comprised primarily of expenses associated with the completion of the Phase 3 study of Piclidenoson
for the treatment of psoriasis and two ongoing studies for Namodenoson, a Phase 3 study in the treatment of advanced liver cancer and
a Phase 2b study for SLD. The increase is primarily due to an increase in expenses associated with Namodenoson.
General and administrative expenses
General and administrative
expenses were $1.47 million for the six months ended June 30, 2023 compared to $1.57 million for the same period in 2022. The decrease
is primarily due to the decrease in public and investor relations expenses and in directors and officer’s insurance policy premium.
We expect that general and administrative expenses will remain at the same level through 2023.
Financial income, net
Financial income, net for
the six months ended June 30, 2023 was $0.27 million compared to financial expense, net of $0.18 million for the same period in 2022.
The decrease in financial expense, net was mainly due to revaluation of our short-term investment and increase in interest income from
deposits in 2023.
Liquidity and Capital Resources
Since inception, we have funded
our operations primarily through public (in Israel and US) and private offerings of our equity securities and payments received under
our strategic licensing arrangements. As of June 30, 2023, we had approximately $9.60 million in cash, cash equivalents and short-term
deposits, and have invested most of our available cash funds in ongoing cash accounts.
We may be able to use U.S.
taxes withheld as credits against Israeli corporate income tax when we have income, if at all, but there can be no assurance that we will
be able to realize the credits. In addition, we believe that we may be entitled to a refund of such withholding tax from the U.S. government
but there can be no assurance that we will be entitled to such a refund.
Net cash used in operating
activities was $5.04 million for the six months ended June 30, 2023, compared with net cash used in operating activities of $6.07 million
for the same period in 2022. The $1.03 million decrease in the net cash used in operating activities during the six months ended June
30, 2023 compared to the same period in 2022, was mainly due to higher costs in 2022 due to completion of the Phase III study of Piclidenoson
for the treatment of psoriasis in during 2022.
Net cash used in investing
activities for the six months ended June 30, 2023 was $1.00 million compared with net cash provided by investing activities of $3.49 million
for the same period in 2022. The $4.49 million decrease in the net cash provided by investing activities during the six months ended June
30, 2023 compared to the same period in 2022, was mainly due to maturity in short term deposit.
Net cash provided by financing
activities was $6.52 million for the six months ended June 30, 2023 compared to no net cash provided by financing activities for the same
period in 2022. Net cash provided by financing activities for the six months ended June 30, 2023 was due to proceeds from issuance of
share capital and warrants.
Developing drugs, conducting
clinical trials and commercializing products is expensive and we will need to raise substantial additional funds to achieve our strategic
objectives. Although we believe our existing financial resources as of the date of issuance of this Form 6-K, will be sufficient to fund
our projected cash requirements at least through the next twelve months, we will require significant additional financing to fund our
operations. Additional financing may not be available on acceptable terms, if at all. Our future capital requirements will depend on many
factors, including:
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the level of research and development investment required to develop our product candidates; |
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the failure to obtain regulatory approval or achieve commercial success of our product candidates, including Piclidenoson, Namodenoson and CF602; |
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the results of our preclinical studies and clinical trials for our earlier stage product candidates, and any decisions to initiate clinical trials if supported by the preclinical results; |
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the costs, timing and outcome of regulatory review of our product candidates that progress to clinical trials; |
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our ability to partner or sub-license any of our product candidates; |
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the costs of preparing, filing and prosecuting patent applications, maintaining and enforcing our issued patents and defending intellectual property-related claims; |
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the cost of commercialization activities if any of our product candidates are approved for sale, including marketing, sales and distribution costs; |
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the cost of manufacturing our product candidates and any products we successfully commercialize; |
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the timing, receipt and amount of sales of, or royalties on, our future products, if any; |
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the expenses needed to attract and retain skilled personnel; |
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any product liability or other lawsuits related to our products; |
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the extent to which we acquire or invest in businesses, products or technologies and other strategic relationships; |
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the costs of financing unanticipated working capital requirements and responding to competitive pressures; and |
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maintaining minimum shareholders’ equity requirements and complying with other continue listing standards under the NYSE American Company Guide; and |
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the impact of the COVID-19 outbreak and the Russian invasion of Ukraine, which may exacerbate the magnitude of the factors discussed above. |
Until we can generate significant
continuing revenues, we expect to satisfy our future cash needs through payments received under our license agreements, debt or equity
financings, or by out-licensing other product candidates. We cannot be certain that additional funding will be available to us on acceptable
terms, or at all. If funds are not available, we may be required to delay, reduce the scope of, or eliminate one or more of our research
or development programs or our commercialization efforts.
Research and Development, Patents and Licenses, Etc.
Our research and development
expenses consist primarily of salaries and related personnel expenses, fees paid to external service providers, up-front and milestone
payments under our license agreements, patent-related legal fees, costs of preclinical studies and clinical trials, drug and laboratory
supplies and costs for facilities and equipment. We charge all research and development expenses to operations as they are incurred. We
expect our research and development expense to remain our primary expense in the near future as we continue to develop our products. Increases
or decreases in research and development expenditures are attributable to the number and/or duration of the pre-clinical and clinical
studies that we conduct.
The following table identifies
our current major research and development projects:
Project |
|
Status |
|
Expected or Recent Near Term Milestone |
Piclidenoson |
|
COMFORT Phase III study in psoriasis |
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Preparatory work for pivotal Phase III studies following meetings with
FDA & EMA. |
|
|
|
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|
Namodenoson |
|
Phase III in HCC |
|
Enrolling patients |
|
|
Phase IIb study in SLD |
|
Enrolling patients |
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|
Phase IIa study in pancreatic cancer |
|
Preparatory work for Phase IIa study |
We record certain costs for
each development project on a “direct cost” basis, as they are recorded to the project for which such costs are incurred.
Such costs include, but are not limited to, CRO expenses, drug production for pre-clinical and clinical studies and other pre-clinical
and clinical expenses. However, certain other costs, including but not limited to, salary expenses (including salaries for research and
development personnel), facilities, depreciation, share-based compensation and other overhead costs are recorded on an “indirect
cost” basis, i.e., they are shared among all of our projects and are not recorded to the project for which such costs are incurred.
We do not allocate direct salaries to projects due to the fact that our project managers are generally involved in several projects at
different stages of development, and the related salary expense is not significant to the overall cost of the applicable projects. In
addition, indirect labor costs relating to our support of the research and development process, such as manufacturing, controls, pre-clinical
analysis, laboratory testing and initial drug sample production, as well as rent and other administrative overhead costs, are shared by
many different projects and have never been considered by management to be of significance in its decision-making process with respect
to any specific project. Accordingly, such costs have not been specifically allocated to individual projects.
Set forth below is a summary
of the gross direct costs allocated to our main projects on an individual basis, as well as the gross direct costs allocated to our less
significant projects on an aggregate basis, for the years ended December 31, 2020, 2021 and 2022 and for the six months ended June 30,
2023 and on an aggregate basis since project inception:
| |
($ in thousands) | | |
Six Months Ended | | |
Costs Since | |
| |
Year Ended December 31, | | |
June 30, | | |
Project | |
| |
2020 | | |
2021 | | |
2022 | | |
2023 | | |
Inception | |
| |
| | |
| | |
| | |
| | |
| |
Piclidenoson | |
| 6,046 | | |
| 4,041 | | |
| 2,790 | | |
| 1,032 | | |
| 47,619 | |
Namodenoson | |
| 1,261 | | |
| 3,991 | | |
| 3,383 | | |
| 1,665 | | |
| 21,075 | |
CF602 | |
| - | | |
| 31 | | |
| 6 | | |
| - | | |
| 1,740 | |
Other projects | |
| 2,199 | | |
| - | | |
| - | | |
| - | | |
| 4,129 | |
Total gross direct project costs (1) | |
| 9,506 | | |
| 8,063 | | |
| 6,179 | | |
| 2,697 | | |
| 74,563 | |
(1) |
Does not include indirect project costs and overhead, such as payroll and related expenses (including stock-based compensation), facilities, depreciation and impairment of intellectual property, which are included in total research and development expenses in our financial statements. |
From our inception through
June 30, 2023, we have incurred research and development expenses of approximately $143.61 million. We expect that a large percentage
of our research and development expense in the future will be incurred in support of our current and future preclinical and clinical development
projects. Due to the inherently unpredictable nature of preclinical and clinical development processes and given the early stage of our
preclinical product development projects, we are unable to estimate with any certainty the costs we will incur in the continued development
of the product candidates in our pipeline for potential commercialization. Clinical development timelines, the probability of success
and development costs can differ materially from expectations. We expect to continue to test our product candidates in preclinical studies
for toxicology, safety and efficacy, and to conduct additional clinical trials for each product candidate. If we are not able to enter
into an out-licensing arrangement with respect to any product candidate prior to the commencement of later stage clinical trials, we may
fund the trials for the product candidates ourselves.
While we are currently focused
on advancing each of our product development projects, our future research and development expenses will depend on the clinical success
of each product candidate, as well as ongoing assessments of each product candidate’s commercial potential. In addition, we cannot
forecast with any degree of certainty which product candidates may be subject to future out-licensing arrangements, when such out-licensing
arrangements will be secured, if at all, and to what degree such arrangements would affect our development plans and capital requirements.
As we obtain results from
clinical trials, we may elect to discontinue or delay clinical trials for certain product candidates or projects in order to focus our
resources on more promising product candidates or projects. Completion of clinical trials by us or our licensees may take several years
or more, but the length of time generally varies according to the type, complexity, novelty and intended use of a product candidate.
The cost of clinical trials
may vary significantly over the life of a project as a result of differences arising during clinical development, including, among others:
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the number of sites included in the clinical trials; |
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the length of time required to enroll suitable patients; |
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the number of patients that participate in the clinical trials; |
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the duration of patient follow-up; |
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the development stage of the product candidate; and |
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the efficacy and safety profile of the product candidate. |
We expect our research and
development expenses to increase in the future from current levels as we continue the advancement of our clinical trials and preclinical
product development and to the extent we in-license new product candidates. The lengthy process of completing clinical trials and seeking
regulatory approval for our product candidates requires expenditure of substantial resources. Any failure or delay in completing clinical
trials, or in obtaining regulatory approvals, could cause a delay in generating product revenue and cause our research and development
expenses to increase and, in turn, have a material adverse effect on our operations. Because of the factors set forth above, we are not
able to estimate with any certainty when we would recognize any net cash inflows from our projects.
Trend Information.
We are a development stage
company and it is not possible for us to predict with any degree of accuracy the outcome of our research, development or commercialization
efforts. As such, it is not possible for us to predict with any degree of accuracy any significant trends, uncertainties, demands, commitments
or events that are reasonably likely to have a material effect on our net sales or revenues, income from continuing operations, profitability,
liquidity or capital resources, or that would cause financial information to not necessarily be indicative of future operating results
or financial condition. However, to the extent possible, certain trends, uncertainties, demands, commitments and events are identified
in the preceding subsections.
Off-Balance Sheet Arrangements.
We have no off-balance sheet
arrangements that have had or are reasonably likely to have a current or future effect on our financial condition, changes in financial
condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital resources that are material to investors.
7
Exhibit 99.2
CAN-FITE BIOPHARMA LTD.
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
AS OF JUNE 30, 2023
UNAUDITED
IN U.S. DOLLARS
INDEX
- - - - - - - - - - -
CAN-FITE BIOPHARMA LTD.
CONDENSED
CONSOLIDATED BALANCE SHEETS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
| |
June 30, | | |
December 31, | |
| |
2023 | | |
2022 | |
ASSETS | |
| | |
| |
| |
| | |
| |
CURRENT ASSETS: | |
| | |
| |
| |
| | |
| |
Cash and cash equivalents | |
$ | 3,458 | | |
$ | 2,978 | |
Short term deposits | |
| 6,147 | | |
| 5,001 | |
Prepaid expenses and other current assets | |
| 1,293 | | |
| 1,170 | |
Short-term investment | |
| 11 | | |
| 8 | |
| |
| | | |
| | |
Total current assets | |
| 10,909 | | |
| 9,157 | |
| |
| | | |
| | |
NON-CURRENT ASSETS: | |
| | | |
| | |
| |
| | | |
| | |
Operating lease right of use assets | |
| 87 | | |
| 84 | |
Property, plant and equipment, net | |
| 36 | | |
| 42 | |
| |
| | | |
| | |
Total non-current assets | |
| 123 | | |
| 126 | |
| |
| | | |
| | |
Total assets | |
$ | 11,032 | | |
$ | 9,283 | |
The accompanying notes are an integral part of
the Condensed consolidated financial statements.
CAN-FITE BIOPHARMA LTD.
CONDENSED
CONSOLIDATED BALANCE SHEETS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
| |
June 30, | | |
December 31, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
LIABILITIES AND SHAREHOLDERS’ EQUITY | |
| | |
| |
| |
| | |
| |
CURRENT LIABILITIES: | |
| | |
| |
| |
| | |
| |
Trade payables | |
$ | 810 | | |
$ | 896 | |
Current maturity of operating lease liability | |
| 44 | | |
| 48 | |
Deferred revenues | |
| 783 | | |
| 783 | |
Other accounts payable | |
| 596 | | |
| 775 | |
| |
| | | |
| | |
Total current liabilities | |
| 2,233 | | |
| 2,502 | |
| |
| | | |
| | |
NON-CURRENT LIABILITIES: | |
| | | |
| | |
| |
| | | |
| | |
Long - term operating lease liability | |
| 22 | | |
| 14 | |
Deferred revenues | |
| 1,903 | | |
| 2,295 | |
| |
| | | |
| | |
Total long-term liabilities | |
| 1,925 | | |
| 2,309 | |
| |
| | | |
| | |
CONTIGENT LIABILITIES AND COMMITMENTS | |
| | | |
| | |
| |
| | | |
| | |
SHAREHOLDERS’ EQUITY: | |
| | | |
| | |
| |
| | | |
| | |
Ordinary shares of no-par value - Authorized: 5,000,000,000 shares at June 30, 2023 and December 31, 2022; Issued and outstanding: 1,224,837,393 and 815,746,293 shares as of June 30, 2023 and December 31, 2022 | |
| - | | |
| - | |
Additional paid-in capital | |
| 160,814 | | |
| 154,192 | |
Accumulated other comprehensive income | |
| 1,127 | | |
| 1,127 | |
Accumulated deficit | |
| (155,067 | ) | |
| (150,847 | ) |
| |
| | | |
| | |
Total equity | |
| 6,874 | | |
| 4,472 | |
| |
| | | |
| | |
Total liabilities and shareholders’ equity | |
$ | 11,032 | | |
$ | 9,283 | |
The accompanying notes are an integral part of
the Condensed consolidated financial statements.
CAN-FITE BIOPHARMA LTD.
CONDENSED
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
| |
Six months ended June 30, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Revenues | |
$ | 392 | | |
$ | 409 | |
| |
| | | |
| | |
Research and development expenses | |
| (3,417 | ) | |
| (3,273 | ) |
General and administrative expenses | |
| (1,471 | ) | |
| (1,576 | ) |
| |
| | | |
| | |
Operating loss | |
| (4,496 | ) | |
| (4,440 | ) |
| |
| | | |
| | |
Total financial income (expense), net | |
| 276 | | |
| (185 | ) |
| |
| | | |
| | |
Net loss | |
| (4,220 | ) | |
| (4,625 | ) |
| |
| | | |
| | |
Basic and diluted net loss per share | |
| (0.00 | ) | |
| (0.00 | ) |
| |
| | | |
| | |
Weighted average number of ordinary shares used in computing basic and diluted net loss per share | |
| 1,202,110,110 | | |
| 815,746,293 | |
The accompanying notes are an integral part of
the Condensed consolidated financial statements.
CAN-FITE BIOPHARMA LTD.
CONDENSED
CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
| |
Ordinary shares | | |
Additional
paid-in | | |
Accumulated
other
comprehensive
| | |
Accumulated
| | |
Total | |
| |
Number | | |
Amount | | |
capital | | |
income | | |
deficit | | |
equity | |
| |
| | |
| | |
| | |
| | |
| | |
| |
Balance as of January 1, 2023 | |
| 815,746,293 | | |
| - | | |
$ | 154,192 | | |
$ | 1,127 | | |
$ | (150,847 | ) | |
$ | 4,472 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Net loss | |
| - | | |
| - | | |
| - | | |
| - | | |
| (4,220 | ) | |
| (4,220 | ) |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Issuance of ordinary shares and warrants, net of issuance costs of
$973 | |
| 90,000,000 | | |
| - | | |
| 6,526 | | |
| - | | |
| - | | |
| 6,526 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Issuance of ordinary shares due to exercise of warrants | |
| 319,091,100 | | |
| - | | |
| 1 | | |
| - | | |
| - | | |
| 1 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Share-based compensation | |
| - | | |
| - | | |
| 95 | | |
| - | | |
| - | | |
| 95 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Balance as of June 30, 2023 | |
| 1,224,837,393 | | |
$ | - | | |
$ | 160,814 | | |
$ | 1,127 | | |
$ | (155,067 | ) | |
$ | 6,874 | |
| |
Ordinary shares | | |
Additional
paid-in | | |
Accumulated
other
comprehensive
| | |
Accumulated | | |
Total | |
| |
Number | | |
Amount | | |
capital | | |
income | | |
deficit | | |
equity | |
| |
| | |
| | |
| | |
| | |
| | |
| |
Balance as of January 1, 2022 | |
| 815,746,293 | | |
$ | 60,654 | | |
$ | 93,275 | | |
$ | 1,127 | | |
$ | (140,674 | ) | |
$ | 14,382 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Net loss | |
| - | | |
| - | | |
| - | | |
| - | | |
| (4,625 | ) | |
| (4,625 | ) |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Share-based compensation | |
| - | | |
| - | | |
| 135 | | |
| - | | |
| - | | |
| 135 | |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
Balance as of June 30, 2022 | |
| 815,746,293 | | |
$ | 60,654 | | |
$ | 93,410 | | |
$ | 1,127 | | |
$ | (145,299 | ) | |
$ | 9,892 | |
The accompanying notes are an integral part of
the Condensed consolidated financial statements.
CAN-FITE BIOPHARMA LTD.
CONDENSED
CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
| |
Six months ended June 30, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Cash flows from operating activities: | |
| | |
| |
| |
| | |
| |
Net loss | |
$ | (4,220 | ) | |
$ | (4,625 | ) |
| |
| | | |
| | |
Adjustments required to reconcile net loss to net cash used in operating activities: | |
| | | |
| | |
| |
| | | |
| | |
Depreciation of property, plant and equipment | |
| 8 | | |
| 6 | |
Reduction in the carrying amount of operating lease right of use asset | |
| 28 | | |
| 27 | |
Share-based compensation | |
| 95 | | |
| 135 | |
Changes in fair value of short-term investment | |
| (3 | ) | |
| 198 | |
Financial expenses (income), net | |
| (146 | ) | |
| 92 | |
Change in prepaid expenses, and other current assets | |
| (123 | ) | |
| (894 | ) |
Decrease in operating lease liability | |
| (27 | ) | |
| (37 | ) |
Decrease in trade payables | |
| (86 | ) | |
| (130 | ) |
Decrease in deferred revenues | |
| (392 | ) | |
| (409 | ) |
Decrease in other accounts payable | |
| (179 | ) | |
| (441 | ) |
| |
| | | |
| | |
Net cash used in operating activities | |
$ | (5,045 | ) | |
$ | (6,078 | ) |
The accompanying notes are an integral part of
the Condensed consolidated financial statements.
CAN-FITE BIOPHARMA LTD.
CONDENSED
CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
| |
Six months ended June 30, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Cash flows from investing activities: | |
| | |
| |
Purchase of property, plant and equipment | |
| (2 | ) | |
| (5 | ) |
Maturity of short-term deposits | |
| 5,000 | | |
| 17,997 | |
Investment in short-term deposits | |
| (6,000 | ) | |
| (14,500 | ) |
| |
| | | |
| | |
Net cash provided by (used in) investing activities | |
$ | (1,002 | ) | |
$ | 3,492 | |
| |
| | | |
| | |
Cash flows from financing activities: | |
| | | |
| | |
| |
| | | |
| | |
Proceeds from issuance of ordinary shares and warrants, net of issuance costs | |
| 6,526 | | |
| - | |
Proceeds from issuance of ordinary share due to exercise of warrants | |
| 1 | | |
| - | |
| |
| | | |
| | |
Net cash provided by financing activities | |
$ | 6,527 | | |
$ | - | |
| |
| | | |
| | |
Exchange differences on balances of cash and cash equivalents | |
| * | ) | |
| (92 | ) |
| |
| | | |
| | |
Increase (decrease) in cash and cash equivalents | |
| 480 | | |
| (2,678 | ) |
Cash and cash equivalents at the beginning of the period | |
| 2,978 | | |
| 4,390 | |
| |
| | | |
| | |
Cash and cash equivalents at the end of the period | |
$ | 3,458 | | |
$ | 1,712 | |
| |
| | | |
| | |
Supplemental disclosures of noncash investing and financing activities: | |
| | | |
| | |
| |
| | | |
| | |
Lease liabilities arising from obtaining right-of-use-assets | |
$ | 32 | | |
| - | |
The accompanying notes are an integral part of
the Condensed consolidated financial statements.
CAN-FITE BIOPHARMA LTD.
NOTES TO
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
| a. | Can-Fite Biopharma Ltd. (the “Company”) was incorporated and started to operate in September 1994 as a private Israeli company. Can-Fite is a clinical-stage biopharmaceutical company focused on developing orally bioavailable small molecule therapeutic products for the treatment of psoriasis, liver cancer, SLD and erectile dysfunction. Its platform technology utilizes the Gi protein associated A3AR as a therapeutic target. A3AR is highly expressed in patholological body cells such as inflammatory and cancer cells, and has a low expression in normal cells, suggesting that the receptor could be a specific target for pharmacological intervention. The Company’s pipeline of drug candidates are synthetic, highly specific agonists and allosteric modulators at the A3AR. The Company’s ordinary shares have been publicly traded on the Tel-Aviv Stock Exchange since October 2005 under the symbol “CFBI” and the Company’s American Depositary Shares (“ADSs”) began public trading on the over the counter market in the U.S. in October 2012 and since November 2013 the Company’s ADSs have been publicly traded on the NYSE American under the symbol “CANF”. Each ADS represents 300 ordinary shares of the Company. |
| | |
| b. | During the six months ended June 30, 2023, the Company incurred net losses of USD 4,220 and it had negative cash flows from operating activities in the amount of USD 5,045. Furthermore, the Company intends to continue to finance its operating activities by raising capital and seeking collaborations with multinational companies in the industry. There are no assurances that the Company will be successful in obtaining an adequate level of financing needed for its long-term research and development activities. If the Company will not have sufficient liquidity resources, the Company may not be able to continue the development of all of its products or may be required to implement a cost reduction and may be required to delay part of its development programs. The Company’s management and board of directors are of the opinion that its current financial resources will be sufficient to continue the development of the Company’s products for at least the next twelve months beyond the date of the filing date of the consolidated financial statements. |
NOTE 2:- |
SIGNIFICANT ACCOUNTING POLICIES |
The
significant accounting policies that have been applied in the preparation of the unaudited consolidated Condensed financial statements
are identical to those that were applied in preparation of the Company’s most recent annual financial statements for the year ended
December 31, 2022 included in the Annual Report on Form 20-F.
NOTE 3:- |
UNAUDITED CONDENSED FINANCIAL STATEMENTS |
These unaudited condensed consolidated financial statements have been
prepared as of June 30, 2023 and for the six months period then ended. Accordingly, certain information and footnote disclosures normally
included in annual financial statements prepared in accordance with U.S. GAAP have been omitted. These unaudited condensed consolidated
financial statements should be read in conjunction with the audited financial statements and the accompanying notes of the Company for
the year ended December 31, 2022 that are included in the Company’s Annual Report on Form 20-F, filed with the Securities and Exchange
Commission on March 30, 2023 (the “Annual Report on Form 20-F”). The results of operations presented are not necessarily indicative
of the results to be expected for the year ending December 31, 2023.
CAN-FITE BIOPHARMA LTD.
NOTES TO
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
NOTE 4:- |
DEFERRED REVENUES |
Contract liabilities include amounts
received from customers for which revenue has not yet been recognized. Contract liabilities amounted to $2,686 and $3,078 as
of June 30, 2023 and December 31, 2022, respectively and are presented under deferred revenues. During the six-month period ended June
30, 2023, the Company recognized revenues in the amount of $392 which have been included in the contract liabilities at December 31,
2022.
NOTE 5:- |
FAIR VALUE MEASUREMENTS |
In accordance with ASC 820 “Fair
Value Measurements and Disclosures”, the Company measures its short-term investment at fair value. Short-term investments are classified
within Level 1 as the valuation inputs are valuations based on quoted prices in active markets for identical assets that the Company has
the ability to access. The company’s short-term investment consists of an equity investment in a publicly traded company.
The Company’s financial assets and
liabilities measured at fair value on a recurring basis, consisted of the following types of instruments as of the following dates: instruments
as of the following dates:
| |
June 30, 2023 | |
| |
Fair value measurements | |
Description | |
Fair value | | |
Level 1 | | |
Level 2 | | |
Level 3 | |
| |
| | |
| | |
| | |
| |
Short-term equity investment | |
$ | 11 | | |
$ | 11 | | |
$ | - | | |
$ | - | |
| |
December 31, 2022 | |
| |
Fair value measurements | |
Description | |
Fair value | | |
Level 1 | | |
Level 2 | | |
Level 3 | |
| |
| | |
| | |
| | |
| |
Short-term equity investment | |
$ | 8 | | |
$ | 8 | | |
$ | - | | |
$ | - | |
NOTE 6:- |
EARNING PER SHARE |
Basic and diluted net loss per share
is calculated based on the weighted average number of ordinary shares outstanding during each period. Diluted net loss per share is calculated
based on the weighted average number of ordinary shares outstanding during each year, plus dilutive potential in accordance with ASC 260,
“Earnings per Share”.
CAN-FITE BIOPHARMA LTD.
NOTES TO
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
NOTE 6:- |
EARNING PER SHARE (Cont.) |
The following table sets forth the
computation of basic and diluted net loss per share for the periods presented:
| |
Six month ended
June 30, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Numerator: | |
| | |
| |
Net loss applicable to shareholders of ordinary shares | |
$ | (4,220 | ) | |
$ | (4,625 | ) |
| |
| | | |
| | |
Denominator: | |
| | | |
| | |
Weighted average shares used in computing basic and diluted net loss per share | |
| 1,202,110,110 | | |
| 815,746,293 | |
Net loss per share of ordinary share, basic and diluted | |
$ | (0.00 | ) | |
$ | (0.00 | ) |
All outstanding share options and warrants
for the period ended June 30, 2023 and 2022 have been excluded from the calculation of the diluted net loss per share, because all such
securities are anti-dilutive for all periods presented.
The potential shares of ordinary shares
that were excluded from the computation of diluted net loss per share attributable to ordinary shareholders for the periods presented
because including them would have been anti-dilutive are as follows:
| |
Six month ended
June 30,
2023 | | |
Six month ended
June 30,
2022 | |
| |
| | |
| |
Options | |
| 42,477,000 | | |
| 19,256,200 | |
| |
| | | |
| | |
Warrants | |
| 1,222,016,340 | | |
| 377,947,640 | |
| |
| | | |
| | |
Total | |
| 1,264,493,340 | | |
| 397,203,840 | |
CAN-FITE BIOPHARMA LTD.
NOTES TO
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
NOTE 7:- |
SHAREHOLDERS EQUITY |
| 1. | On January 11, 2023, the Company entered into a securities purchase
agreement (the “RD Purchase Agreement”), pursuant to which the Company agreed to sell and issue in a registered direct offering
(the “Registered Direct Offering”) an aggregate of 90,000,000 ordinary shares for a purchase price of $0.018 per share (the
“RD Shares”) and pre-funded warrants to purchase up to 210,000,000 of the Company’s ordinary shares at a purchase price
of $0.018 per share and at an immaterial exercise price (the “Pre-funded Warrants”), and, unregistered Series A warrants to
purchase up to 300,000,000 ordinary shares for an exercise price of $0.02 per shares (the “Series A Warrants”), and unregistered
Series B warrants to purchase up to 300,000,000 ordinary shares for exercise price of $0.018 per share (the “Series B Warrants”). |
In addition, the Company entered into a securities purchase agreement
(the “PIPE Purchase Agreement,” and together with the RD Purchase Agreement, the “Purchase Agreements”) pursuant
to which the Company agreed to sell and issue in a concurrent private placement (the “PIPE Offering,” and together with the
Registered Direct Offering, the “Offerings”) unregistered Pre-funded Warrants to purchase up to 109,091,100 of the Company’
ordinary shares at purchase price of $0.018 per share and additional immaterial exercise price per share, unregistered Series A Warrants
to purchase up to 109,091,100 of the Company’s ordinary shares for an exercise price of $0.02 per share and unregistered Series
B Warrants to purchase up to 109,091,100 of the Company’s ordinary shares for an exercise price of $0.018 per share.
Moreover, the Company has also issued a placement agent warrants (the
“Placement Agent Warrants”) on substantially the same terms as the Series A Warrants to purchase up to 28,636,500 of the Company’s
ordinary shares for an exercise price of $0.022 per share.
As part of the aforementioned Offerings, the Company paid an aggregate
amount of $973 issuance costs.
The Company received total consideration of $6,526 net of issuance
costs from the above mentioned issuance of shares, prefunded warrants and Series A and B warrants.
The Company accounted for the aforementioned
warrants as freestanding instrument classified at part of the Company’s permanent equity in accordance with ASC-480 and ASC-815.
| 2. | The Company amended certain warrants to purchase up to an aggregate
of 180,000,000 ordinary shares that were issued in December 2021 to the investor in this offering and private placement by reducing the
exercise prices from $0.067 per share to $0.018 per share. |
The Company accounted for the reduced
in the warrants exercise price as issuance costs to be recorded in the Company’s additional paid in capital in accordance with ASC-815.
| 3. | During the six months ended June 30, 2023, certain investors exercised
pre-funded warrants and purchased 319,091,100 of the Company’s ordinary shares for an exercise price at an immaterial amount. |
On May 1, 2023, the Company’s
board of directors approved a grant of 15,500,000 unlisted options exercisable into 15,500,000 of the Company’s ordinary shares
to the Company’s employees for an exercise price of NIS 0.026 per share and 40,000,000 unlisted options exercisable into 40,000,000
of the Company’s ordinary shares to the Company’s directors and chairman of the board of directors (subject to shareholders’
approval which was obtained on August 7, 2023, subsequent to balance sheet date) for an exercise price of NIS 0.026 per share.
The options will vest on a quarterly
basis for a period of 4 years from the date of grant.
CAN-FITE BIOPHARMA LTD.
NOTES TO
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)
U.S dollars in thousands (except for share
and per share data)
NOTE 7:- |
SHAREHOLDERS EQUITY (Cont.) |
In addition, the Company’s board of
directors has also approved the increase of the options pool reserved under the Plan for issuance of ordinary share by 50,000,000 additional
options to a total of 85,000,000. As of June 30, 2023, 42,523,000 options are available for a future grant.
The following table lists the number
of share options and their weighted average exercise prices in option plans of employees, directors and consultants for the six months
period ended June 30, 2023 and related information:
| |
Number of options | | |
Weighted average exercise price | | |
Weighted
average
remaining
contractual
terms
(in years) | | |
Aggregate
intrinsic
value | |
| |
| | |
| | |
| | |
| |
Outstanding at December 31, 2022 | |
| 27,002,200 | | |
| 0.13 | | |
| 7.14 | | |
| - | |
Grants | |
| 15,500,000 | | |
| 0.01 | | |
| - | | |
| - | |
Forfeited/expired | |
| (25,200 | ) | |
| 4.05 | | |
| - | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Outstanding at June 30, 2023 | |
| 42,477,000 | | |
| 0.08 | | |
| 7.83 | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Vested and expected to vest at June 30, 2023 | |
| 42,477,000 | | |
| 0.08 | | |
| 7.83 | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Exercisable at June 30, 2023 | |
| 14,217,625 | | |
| 0.17 | | |
| 6.61 | | |
| - | |
- 12 -
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Exhibit 99.3
Can-Fite Reports Second Quarter 2023
Financial Results & Progress in Two Pivotal Phase III Clinical Studies
PETACH TIKVA, Israel, August 31, 2023 -- Can-Fite
BioPharma Ltd. (NYSE American: CANF) (TASE: CANF), a biotechnology company advancing a pipeline of proprietary small molecule drugs that
address oncology, inflammatory and liver diseases, today announced financial results for the six months ended June 30, 2023.
Clinical Progress
Pivotal Phase III Advanced Liver Cancer Study—Can-Fite’s
pivotal Phase III liver cancer study, Liveration, which continues enrollment is designed to assess Namodenoson in the treatment of patients
with advanced hepatocellular carcinoma (HCC) and underlying Child Pugh B7 (CPB7) who have not responded to one or two other lines of therapy.
The primary endpoint is overall survival. An interim analysis will be conducted by an Independent Data Monitoring Committee (IDMC) after
50% of the planned 450 patients are enrolled and treated.
Breakthrough Abstract Award–Can-Fite
was recently granted a prestigious Breakthrough Abstract Award by the American Society of Clinical Oncology (ASCO) Conquer Cancer Foundation
for the development of a novel approach to treat advanced liver cancer with the A3 adenosine receptor agonist, Namodenoson.
Exploratory Phase II Pancreatic Cancer Study—Can-Fite
is preparing an open-label Phase II exploratory trial to assess the safety and efficacy of Namodenoson in the treatment of patients with
pancreatic cancer who have received at least one previous systemic therapy. In pre-clinical studies, Namodenoson demonstrated a robust
anti-growth effect against pancreatic carcinoma, reaching 90% growth inhibition. The mechanism of action entails de-regulation of the
Wnt signal transduction pathway, a key modulator of pancreatic carcinoma cell growth.
ASCO Recognition—Can-Fite’s
pancreatic cancer program received recognition from ASCO when its study titled “Effects of Namodenoson on Pancreatic Carcinoma:
Preclinical Evidence” was published in the Journal of Clinical Oncology supplement of the 2023 ASCO Annual Meeting
Proceedings.
Preparatory Work for Pivotal Phase III Psoriasis
Study; Can Fite Received Green Light from FDA and EMA— Following positive responses from the U.S. Food and Drug Administration
(FDA) and the European Medicines Agency (EMA) for its registration plan and pivotal Phase III study protocol for Piclidenoson in the treatment
of moderate to severe psoriasis, the Company is preparing for study initiation. The FDA requested two Phase III studies and also encouraged
the Company to enroll adolescent patients due to Piclidenoson’s strong safety profile demonstrated over its development history
and prior clinical studies. Can-Fite has submitted to the FDA a pediatric plan to allow the registration of Piclidenoson for the treatment
of adolescents. Inclusion of adolescents for the psoriasis Indication is expected to broaden the market.
Development for Treatment of Lowe Syndrome,
a Rare Genetic Disease—Researchers at the University of Naples Federico II and The Telethon Institute of Genetics and Medicine
(TIGEM) in Italy found Piclidenoson to be effective in pre-clinical studies for the treatment of Lowe Syndrome. Can-Fite and Fondazione
Telethon signed an agreement outlining their collaboration for the development of Piclidenoson for the treatment Lowe Syndrome, a rare
genetic disease with no treatment available, and an estimated $100 million treatment market in the U.S. alone.
“With two ongoing studies and two more about
to commence in large treatment markets with unmet needs, we continue to advance our late-stage development pipeline to bring our potentially
game-changing drugs to market,” stated Can-Fite CEO & CFO Motti Farbstein.
Dr. Pnina Fishman, Can-Fite’s CSO and Executive
Chairman added, “We are particularly excited about our entry into the rare genetic disease field with the discovery of Piclidenoson’s
efficacy in Lowe Syndrome in pre-clinical studies. Given Piclidenoson’s very favorable safety profile, we believe it will be a good
candidate for directly entering advanced stage trials in children and adolescents living with Lowe Syndrome. Rare genetic diseases can
have a more direct rapid path to regulatory approval with smaller trial sizes due to the pressing need in a small, unserved patient population.”
Financial Results
Revenues for the six months ended June 30, 2023
were $0.39 million compared to revenues of $0.41 million during the six months ended June 30, 2022. Revenues for the six months ended
June 30, 2023 and June 30, 2022 comprised of recognition of a portion of advance payments received under distribution agreements with
Gebro, CKD, Cipher and Ewopharma.
Research and development expenses for the six
months ended June 30, 2023 were $3.41 million compared with $3.27 million for the same period in 2022. Research and development expenses
for the first half of 2023 comprised primarily of expenses associated with the completion of the Phase 3 study of Piclidenoson for the
treatment of psoriasis and two ongoing studies for Namodenoson, a Phase 3 study in the treatment of advanced liver cancer and a Phase
2b study for SLD. The increase is primarily due to an increase in expenses associated with Namodenoson.
General and administrative expenses were $1.47
million for the six months ended June 30, 2023 compared to $1.57 million for the same period in 2022. The decrease is primarily due to
the decrease in public and investor relations expenses and in directors and officer’s insurance policy premium. We expect that general
and administrative expenses will remain at the same level through 2023.
Financial income, net for the six months ended
June 30, 2023 was $0.27 million compared to financial expense, net of $0.18 million for the same period in 2022. The decrease in financial
expense, net was mainly due to revaluation of our short-term investment and increase in interest income from deposits in 2023.
Net loss for the six months ended June 30, 2023
was $4.22 million compared with a net loss of $4.62 million for the six months ended June 30, 2022. The decrease in net loss for the six
months ended June 30, 2023 was primarily attributable to the increase in finance income, net.
As of June 30, 2023, Can-Fite had cash and cash
equivalents and short term deposits of $9.60 million as compared to $7.98 million at December 31, 2022. The decrease in cash during the
six months ended June 30, 2023 is due to the ongoing operations of the Company.
The Company’s consolidated financial results for
the six months ended June 30, 2023 are presented in accordance with US GAAP Reporting Standards.
CONSOLIDATED BALANCE SHEETS
U.S dollars in thousands (except for share and per share data)
| |
June 30, | | |
December 31, | |
| |
2023 | | |
2022 | |
| |
Unaudited | | |
| |
| |
| | |
| |
ASSETS | |
| | |
| |
| |
| | |
| |
CURRENT ASSETS: | |
| | |
| |
| |
| | |
| |
Cash and cash equivalents | |
$ | 3,458 | | |
$ | 2,978 | |
Short term deposits | |
| 6,147 | | |
| 5,001 | |
Prepaid expenses and other current assets | |
| 1,293 | | |
| 1,170 | |
Short-term investment | |
| 11 | | |
| 8 | |
| |
| | | |
| | |
Total current assets | |
| 10,909 | | |
| 9,157 | |
| |
| | | |
| | |
NON-CURRENT ASSETS: | |
| | | |
| | |
| |
| | | |
| | |
Operating lease right of use assets | |
| 87 | | |
| 84 | |
Property, plant and equipment, net | |
| 36 | | |
| 42 | |
| |
| | | |
| | |
Total non-current assets | |
| 123 | | |
| 126 | |
| |
| | | |
| | |
Total assets | |
$ | 11,032 | | |
$ | 9,283 | |
CONSOLIDATED BALANCE SHEETS
U.S dollars in thousands (except for share and per share data)
| |
June 30, | | |
December 31, | |
| |
2023 | | |
2022 | |
| |
Unaudited | | |
| |
| |
| | |
| |
LIABILITIES AND SHAREHOLDERS’ EQUITY | |
| | |
| |
| |
| | |
| |
CURRENT LIABILITIES: | |
| | |
| |
| |
| | |
| |
Trade payables | |
$ | 810 | | |
$ | 896 | |
Current maturity of operating lease liability | |
| 44 | | |
| 48 | |
Deferred revenues | |
| 783 | | |
| 783 | |
Other accounts payable | |
| 596 | | |
| 775 | |
| |
| | | |
| | |
Total current liabilities | |
| 2,233 | | |
| 2,502 | |
| |
| | | |
| | |
NON-CURRENT LIABILITIES: | |
| | | |
| | |
| |
| | | |
| | |
Long-term operating lease liability | |
| 22 | | |
| 14 | |
Deferred revenues | |
| 1,903 | | |
| 2,295 | |
| |
| | | |
| | |
Total long-term liabilities | |
| 1,925 | | |
| 2,309 | |
| |
| | | |
| | |
CONTIGENT LIABILITIES AND COMMITMENTS | |
| | | |
| | |
| |
| | | |
| | |
SHAREHOLDERS’ EQUITY: | |
| | | |
| | |
| |
| | | |
| | |
Ordinary shares of no-par value - Authorized: 5,000,000,000 shares at June 30, 2023 and December 31, 2022; Issued and outstanding: 1,224,837,393 and 815,746,293 shares as of June 30, 2023 and December 31, 2022 | |
| - | | |
| - | |
Additional paid-in capital | |
| 160,814 | | |
| 154,192 | |
Accumulated other comprehensive income | |
| 1,127 | | |
| 1,127 | |
Accumulated deficit | |
| (155,067 | ) | |
| (150,847 | ) |
| |
| | | |
| | |
Total equity | |
| 6,874 | | |
| 4,472 | |
| |
| | | |
| | |
Total liabilities and shareholders’ equity | |
$ | 11,032 | | |
$ | 9,283 | |
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
U.S dollars in thousands (except for share and per share
data)
| |
Six months ended June 30, | |
| |
2023 | | |
2022 | |
| |
Unaudited | |
| |
| | |
| |
Revenues | |
$ | 392 | | |
$ | 409 | |
| |
| | | |
| | |
Research and development expenses | |
| (3,417 | ) | |
| (3,273 | ) |
General and administrative expenses | |
| (1,471 | ) | |
| (1,576 | ) |
| |
| | | |
| | |
Operating loss | |
| (4,496 | ) | |
| (4,440 | ) |
| |
| | | |
| | |
Total financial income (expense), net | |
| 276 | | |
| (185 | ) |
| |
| | | |
| | |
Net loss | |
| (4,220 | ) | |
| (4,625 | ) |
| |
| | | |
| | |
Basic and diluted net loss per share | |
| (0.00 | ) | |
| (0.00 | ) |
| |
| | | |
| | |
Weighted average number of ordinary shares used in computing basic and diluted net loss per share | |
| 1,202,110,110 | | |
| 815,746,293 | |
About Can-Fite BioPharma Ltd.
Can-Fite BioPharma Ltd. (NYSE American: CANF)
(TASE: CANF) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion
dollar markets in the treatment of cancer, liver, and inflammatory disease. The Company’s lead drug candidate, Piclidenoson recently reported
topline results in a Phase III trial for psoriasis and is expected to commence a pivotal Phase III. Can-Fite’s cancer and liver drug,
Namodenoson, is being evaluated in a Phase IIb trial for the treatment of steatotic liver disease (SLD), a Phase III pivotal trial for
hepatocellular carcinoma (HCC), and the Company is planning a Phase IIa study in pancreatic cancer. Namodenoson has been granted Orphan
Drug Designation in the U.S. and Europe and Fast Track Designation as a second line treatment for HCC by the U.S. Food and Drug Administration.
Namodenoson has also shown proof of concept to potentially treat other cancers including colon, prostate, and melanoma. CF602, the Company’s
third drug candidate, has shown efficacy in the treatment of erectile dysfunction. These drugs have an excellent safety profile with experience
in over 1,600 patients in clinical studies to date. For more information please visit: www.can-fite.com.
Forward-Looking Statements
This press release may contain forward-looking
statements, about Can-Fite’s expectations, beliefs or intentions regarding, among other things, its product development efforts,
business, financial condition, results of operations, strategies or prospects. All statements in this communication, other than those
relating to historical facts, are “forward looking statements”. Forward-looking statements can be identified by the use of
forward-looking words such as “believe,” “expect,” “intend,” “plan,” “may,”
“should” or “anticipate” or their negatives or other variations of these words or other comparable words or by
the fact that these statements do not relate strictly to historical or current matters. Forward-looking statements relate to anticipated
or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters that
have not yet occurred, these statements are inherently subject to known and unknown risks, uncertainties and other factors that may cause
Can-Fite’s actual results, performance or achievements to be materially different from any future results, performance or achievements
expressed or implied by the forward-looking statements. Important factors that could cause actual results, performance or achievements
to differ materially from those anticipated in these forward-looking statements include, among other things, our history of losses and
needs for additional capital to fund our operations and our inability to obtain additional capital on acceptable terms, or at all; uncertainties
of cash flows and inability to meet working capital needs; the initiation, timing, progress and results of our preclinical studies, clinical
trials and other product candidate development efforts; our ability to advance our product candidates into clinical trials or to successfully
complete our preclinical studies or clinical trials; our receipt of regulatory approvals for our product candidates, and the timing of
other regulatory filings and approvals; the clinical development, commercialization and market acceptance of our product candidates; our
ability to establish and maintain strategic partnerships and other corporate collaborations; the implementation of our business model
and strategic plans for our business and product candidates; the scope of protection we are able to establish and maintain for intellectual
property rights covering our product candidates and our ability to operate our business without infringing the intellectual property rights
of others; competitive companies, technologies and our industry; risks related to the COVID-19 pandemic and the Russian invasion of Ukraine;
risks related to not satisfying the continued listing requirements of NYSE American; and statements as to the impact of the political
and security situation in Israel on our business. More information on these risks, uncertainties and other factors is included from time
to time in the “Risk Factors” section of Can-Fite’s Annual Report on Form 20-F filed with the SEC on March 30, 2023
and other public reports filed with the SEC and in its periodic filings with the TASE. Existing and prospective investors are cautioned
not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Can-Fite undertakes no obligation
to publicly update or review any forward-looking statement, whether as a result of new information, future developments or otherwise,
except as may be required by any applicable securities laws.
Contact
Can-Fite BioPharma
Motti Farbstein
info@canfite.com
+972-3-9241114
6
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Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands |
Jun. 30, 2023 |
Dec. 31, 2022 |
CURRENT ASSETS: |
|
|
Cash and cash equivalents |
$ 3,458
|
$ 2,978
|
Short term deposits |
6,147
|
5,001
|
Prepaid expenses and other current assets |
1,293
|
1,170
|
Short-term investment |
11
|
8
|
Total current assets |
10,909
|
9,157
|
NON-CURRENT ASSETS: |
|
|
Operating lease right of use assets |
87
|
84
|
Property, plant and equipment, net |
36
|
42
|
Total non-current assets |
123
|
126
|
Total assets |
11,032
|
9,283
|
CURRENT LIABILITIES: |
|
|
Trade payables |
810
|
896
|
Current maturity of operating lease liability |
44
|
48
|
Deferred revenues |
783
|
783
|
Other accounts payable |
596
|
775
|
Total current liabilities |
2,233
|
2,502
|
NON-CURRENT LIABILITIES: |
|
|
Long - term operating lease liability |
22
|
14
|
Deferred revenues |
1,903
|
2,295
|
Total long-term liabilities |
1,925
|
2,309
|
CONTIGENT LIABILITIES AND COMMITMENTS |
|
|
SHAREHOLDERS’ EQUITY: |
|
|
Ordinary shares of no-par value - Authorized: 5,000,000,000 shares at June 30, 2023 and December 31, 2022; Issued and outstanding: 1,224,837,393 and 815,746,293 shares as of June 30, 2023 and December 31, 2022 |
|
|
Additional paid-in capital |
160,814
|
154,192
|
Accumulated other comprehensive income |
1,127
|
1,127
|
Accumulated deficit |
(155,067)
|
(150,847)
|
Total equity |
6,874
|
4,472
|
Total liabilities and shareholders’ equity |
$ 11,032
|
$ 9,283
|
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v3.23.2
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|
Jun. 30, 2023 |
Dec. 31, 2022 |
Statement of Financial Position [Abstract] |
|
|
Ordinary shares par value (in Dollars per share) |
|
|
Ordinary shares authorized |
5,000,000,000
|
5,000,000,000
|
Ordinary shares issued |
1,224,837,393
|
815,746,293
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815,746,293
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v3.23.2
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6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Income Statement [Abstract] |
|
|
Revenues |
$ 392
|
$ 409
|
Research and development expenses |
(3,417)
|
(3,273)
|
General and administrative expenses |
(1,471)
|
(1,576)
|
Operating loss |
(4,496)
|
(4,440)
|
Total financial income (expense), net |
276
|
(185)
|
Net loss |
$ (4,220)
|
$ (4,625)
|
Basic net loss per share (in Dollars per share) |
$ 0
|
$ 0
|
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1,202,110,110
|
815,746,293
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v3.23.2
Condensed Consolidated Statements of Changes in Equity (Unaudited) - USD ($) $ in Thousands |
Ordinary shares |
Additional paid-in capital |
Accumulated other comprehensive income |
Accumulated deficit |
Total |
Balance at Dec. 31, 2021 |
$ 60,654
|
$ 93,275
|
$ 1,127
|
$ (140,674)
|
$ 14,382
|
Balance (in Shares) at Dec. 31, 2021 |
815,746,293
|
|
|
|
|
Net loss |
|
|
|
(4,625)
|
(4,625)
|
Share-based compensation |
|
135
|
|
|
135
|
Balance at Jun. 30, 2022 |
$ 60,654
|
93,410
|
1,127
|
(145,299)
|
9,892
|
Balance (in Shares) at Jun. 30, 2022 |
815,746,293
|
|
|
|
|
Balance at Dec. 31, 2022 |
|
154,192
|
1,127
|
(150,847)
|
4,472
|
Balance (in Shares) at Dec. 31, 2022 |
815,746,293
|
|
|
|
|
Net loss |
|
|
|
(4,220)
|
(4,220)
|
Issuance of ordinary shares and warrants, net of issuance costs of $ 973 |
|
6,526
|
|
|
6,526
|
Issuance of ordinary shares and warrants, net of issuance costs of $ 973 (in Shares) |
90,000,000
|
|
|
|
|
Issuance of ordinary shares due to exercise of warrants |
|
1
|
|
|
1
|
Issuance of ordinary shares due to exercise of warrants (in Shares) |
319,091,100
|
|
|
|
|
Share-based compensation |
|
95
|
|
|
95
|
Balance at Jun. 30, 2023 |
|
$ 160,814
|
$ 1,127
|
$ (155,067)
|
$ 6,874
|
Balance (in Shares) at Jun. 30, 2023 |
1,224,837,393
|
|
|
|
|
X |
- DefinitionThe portion of profit or loss for the period, net of income taxes, which is attributable to the parent.
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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Cash flows from operating activities: |
|
|
|
Net loss |
|
$ (4,220)
|
$ (4,625)
|
Adjustments required to reconcile net loss to net cash used in operating activities: |
|
|
|
Depreciation of property, plant and equipment |
|
8
|
6
|
Reduction in the carrying amount of operating lease right of use asset |
|
28
|
27
|
Share-based compensation |
|
95
|
135
|
Changes in fair value of short-term investment |
|
(3)
|
198
|
Financial expenses (income), net |
|
(146)
|
92
|
Change in prepaid expenses, and other current assets |
|
(123)
|
(894)
|
Decrease in operating lease liability |
|
(27)
|
(37)
|
Decrease in trade payables |
|
(86)
|
(130)
|
Decrease in deferred revenues |
|
(392)
|
(409)
|
Decrease in other accounts payable |
|
(179)
|
(441)
|
Net cash used in operating activities |
|
(5,045)
|
(6,078)
|
Cash flows from investing activities: |
|
|
|
Purchase of property, plant and equipment |
|
(2)
|
(5)
|
Maturity of short-term deposits |
|
5,000
|
17,997
|
Investment in short-term deposits |
|
(6,000)
|
(14,500)
|
Net cash provided by (used in) investing activities |
|
(1,002)
|
3,492
|
Cash flows from financing activities: |
|
|
|
Proceeds from issuance of ordinary shares and warrants, net of issuance costs |
|
6,526
|
|
Proceeds from issuance of ordinary share due to exercise of warrants |
|
1
|
|
Net cash provided by financing activities |
|
6,527
|
|
Exchange differences on balances of cash and cash equivalents |
[1] |
|
(92)
|
Increase (decrease) in cash and cash equivalents |
|
480
|
(2,678)
|
Cash and cash equivalents at the beginning of the period |
|
2,978
|
4,390
|
Cash and cash equivalents at the end of the period |
|
3,458
|
1,712
|
Supplemental disclosures of noncash investing and financing activities: |
|
|
|
Lease liabilities arising from obtaining right-of-use-assets |
|
$ 32
|
|
|
|
X |
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v3.23.2
General
|
6 Months Ended |
Jun. 30, 2023 |
General [Abstract] |
|
GENERAL |
| a. | Can-Fite Biopharma Ltd. (the “Company”) was incorporated and started to operate in September 1994 as a private Israeli company. Can-Fite is a clinical-stage biopharmaceutical company focused on developing orally bioavailable small molecule therapeutic products for the treatment of psoriasis, liver cancer, SLD and erectile dysfunction. Its platform technology utilizes the Gi protein associated A3AR as a therapeutic target. A3AR is highly expressed in patholological body cells such as inflammatory and cancer cells, and has a low expression in normal cells, suggesting that the receptor could be a specific target for pharmacological intervention. The Company’s pipeline of drug candidates are synthetic, highly specific agonists and allosteric modulators at the A3AR. The Company’s ordinary shares have been publicly traded on the Tel-Aviv Stock Exchange since October 2005 under the symbol “CFBI” and the Company’s American Depositary Shares (“ADSs”) began public trading on the over the counter market in the U.S. in October 2012 and since November 2013 the Company’s ADSs have been publicly traded on the NYSE American under the symbol “CANF”. Each ADS represents 300 ordinary shares of the Company. | | | | | b. | During the six months ended June 30, 2023, the Company incurred net losses of USD 4,220 and it had negative cash flows from operating activities in the amount of USD 5,045. Furthermore, the Company intends to continue to finance its operating activities by raising capital and seeking collaborations with multinational companies in the industry. There are no assurances that the Company will be successful in obtaining an adequate level of financing needed for its long-term research and development activities. If the Company will not have sufficient liquidity resources, the Company may not be able to continue the development of all of its products or may be required to implement a cost reduction and may be required to delay part of its development programs. The Company’s management and board of directors are of the opinion that its current financial resources will be sufficient to continue the development of the Company’s products for at least the next twelve months beyond the date of the filing date of the consolidated financial statements. |
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v3.23.2
Significant Accounting Policies
|
6 Months Ended |
Jun. 30, 2023 |
Significant Accounting Policies [Abstract] |
|
SIGNIFICANT ACCOUNTING POLICIES |
NOTE 2:- |
SIGNIFICANT ACCOUNTING POLICIES |
The
significant accounting policies that have been applied in the preparation of the unaudited consolidated Condensed financial statements
are identical to those that were applied in preparation of the Company’s most recent annual financial statements for the year ended
December 31, 2022 included in the Annual Report on Form 20-F.
|
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- DefinitionThe entire disclosure for all significant accounting policies of the reporting entity.
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v3.23.2
Unaudited Condensed Financial Statements
|
6 Months Ended |
Jun. 30, 2023 |
Unaudited Condensed Financial Statements [Abstract] |
|
UNAUDITED CONDENSED FINANCIAL STATEMENTS |
NOTE 3:- |
UNAUDITED CONDENSED FINANCIAL STATEMENTS |
These unaudited condensed consolidated financial statements have been
prepared as of June 30, 2023 and for the six months period then ended. Accordingly, certain information and footnote disclosures normally
included in annual financial statements prepared in accordance with U.S. GAAP have been omitted. These unaudited condensed consolidated
financial statements should be read in conjunction with the audited financial statements and the accompanying notes of the Company for
the year ended December 31, 2022 that are included in the Company’s Annual Report on Form 20-F, filed with the Securities and Exchange
Commission on March 30, 2023 (the “Annual Report on Form 20-F”). The results of operations presented are not necessarily indicative
of the results to be expected for the year ending December 31, 2023.
|
X |
- DefinitionThe entire disclosure for condensed financial statements.
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v3.23.2
Deferred Revenues
|
6 Months Ended |
Jun. 30, 2023 |
Deferred Revenues [Abstract] |
|
DEFERRED REVENUES |
NOTE 4:- |
DEFERRED REVENUES |
Contract liabilities include amounts
received from customers for which revenue has not yet been recognized. Contract liabilities amounted to $2,686 and $3,078 as
of June 30, 2023 and December 31, 2022, respectively and are presented under deferred revenues. During the six-month period ended June
30, 2023, the Company recognized revenues in the amount of $392 which have been included in the contract liabilities at December 31,
2022.
|
X |
- DefinitionThe entire disclosure for deferred revenues at the end of the reporting period, and description and amounts of significant changes that occurred during the reporting period. Deferred revenue is a liability as of the balance sheet date related to a revenue producing activity for which revenue has not yet been recognized. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP.
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v3.23.2
Fair Value Measurements
|
6 Months Ended |
Jun. 30, 2023 |
Fair Value Measurements [Abstract] |
|
FAIR VALUE MEASUREMENTS |
NOTE 5:- |
FAIR VALUE MEASUREMENTS |
In accordance with ASC 820 “Fair
Value Measurements and Disclosures”, the Company measures its short-term investment at fair value. Short-term investments are classified
within Level 1 as the valuation inputs are valuations based on quoted prices in active markets for identical assets that the Company has
the ability to access. The company’s short-term investment consists of an equity investment in a publicly traded company.
The Company’s financial assets and
liabilities measured at fair value on a recurring basis, consisted of the following types of instruments as of the following dates: instruments
as of the following dates:
| |
June 30, 2023 | |
| |
Fair value measurements | |
Description | |
Fair value | | |
Level 1 | | |
Level 2 | | |
Level 3 | |
| |
| | |
| | |
| | |
| |
Short-term equity investment | |
$ | 11 | | |
$ | 11 | | |
$ | - | | |
$ | - | |
| |
December 31, 2022 | |
| |
Fair value measurements | |
Description | |
Fair value | | |
Level 1 | | |
Level 2 | | |
Level 3 | |
| |
| | |
| | |
| | |
| |
Short-term equity investment | |
$ | 8 | | |
$ | 8 | | |
$ | - | | |
$ | - | |
|
X |
- DefinitionThe entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.
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v3.23.2
Earning Per Share
|
6 Months Ended |
Jun. 30, 2023 |
Earnings Per Share [Abstract] |
|
EARNING PER SHARE |
NOTE 6:- |
EARNING PER SHARE |
Basic and diluted net loss per share
is calculated based on the weighted average number of ordinary shares outstanding during each period. Diluted net loss per share is calculated
based on the weighted average number of ordinary shares outstanding during each year, plus dilutive potential in accordance with ASC 260,
“Earnings per Share”. The following table sets forth the
computation of basic and diluted net loss per share for the periods presented:
| |
Six month ended
June 30, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Numerator: | |
| | |
| |
Net loss applicable to shareholders of ordinary shares | |
$ | (4,220 | ) | |
$ | (4,625 | ) |
| |
| | | |
| | |
Denominator: | |
| | | |
| | |
Weighted average shares used in computing basic and diluted net loss per share | |
| 1,202,110,110 | | |
| 815,746,293 | |
Net loss per share of ordinary share, basic and diluted | |
$ | (0.00 | ) | |
$ | (0.00 | ) |
All outstanding share options and warrants
for the period ended June 30, 2023 and 2022 have been excluded from the calculation of the diluted net loss per share, because all such
securities are anti-dilutive for all periods presented.
The potential shares of ordinary shares
that were excluded from the computation of diluted net loss per share attributable to ordinary shareholders for the periods presented
because including them would have been anti-dilutive are as follows:
| |
Six month ended
June 30,
2023 | | |
Six month ended
June 30,
2022 | |
| |
| | |
| |
Options | |
| 42,477,000 | | |
| 19,256,200 | |
| |
| | | |
| | |
Warrants | |
| 1,222,016,340 | | |
| 377,947,640 | |
| |
| | | |
| | |
Total | |
| 1,264,493,340 | | |
| 397,203,840 | |
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v3.23.2
Shareholders Equity
|
6 Months Ended |
Jun. 30, 2023 |
Shareholders Equity [Abstract] |
|
SHAREHOLDERS EQUITY |
NOTE 7:- |
SHAREHOLDERS EQUITY |
| 1. | On January 11, 2023, the Company entered into a securities purchase
agreement (the “RD Purchase Agreement”), pursuant to which the Company agreed to sell and issue in a registered direct offering
(the “Registered Direct Offering”) an aggregate of 90,000,000 ordinary shares for a purchase price of $0.018 per share (the
“RD Shares”) and pre-funded warrants to purchase up to 210,000,000 of the Company’s ordinary shares at a purchase price
of $0.018 per share and at an immaterial exercise price (the “Pre-funded Warrants”), and, unregistered Series A warrants to
purchase up to 300,000,000 ordinary shares for an exercise price of $0.02 per shares (the “Series A Warrants”), and unregistered
Series B warrants to purchase up to 300,000,000 ordinary shares for exercise price of $0.018 per share (the “Series B Warrants”). |
In addition, the Company entered into a securities purchase agreement
(the “PIPE Purchase Agreement,” and together with the RD Purchase Agreement, the “Purchase Agreements”) pursuant
to which the Company agreed to sell and issue in a concurrent private placement (the “PIPE Offering,” and together with the
Registered Direct Offering, the “Offerings”) unregistered Pre-funded Warrants to purchase up to 109,091,100 of the Company’
ordinary shares at purchase price of $0.018 per share and additional immaterial exercise price per share, unregistered Series A Warrants
to purchase up to 109,091,100 of the Company’s ordinary shares for an exercise price of $0.02 per share and unregistered Series
B Warrants to purchase up to 109,091,100 of the Company’s ordinary shares for an exercise price of $0.018 per share.
Moreover, the Company has also issued a placement agent warrants (the
“Placement Agent Warrants”) on substantially the same terms as the Series A Warrants to purchase up to 28,636,500 of the Company’s
ordinary shares for an exercise price of $0.022 per share.
As part of the aforementioned Offerings, the Company paid an aggregate
amount of $973 issuance costs.
The Company received total consideration of $6,526 net of issuance
costs from the above mentioned issuance of shares, prefunded warrants and Series A and B warrants.
The Company accounted for the aforementioned
warrants as freestanding instrument classified at part of the Company’s permanent equity in accordance with ASC-480 and ASC-815.
| 2. | The Company amended certain warrants to purchase up to an aggregate
of 180,000,000 ordinary shares that were issued in December 2021 to the investor in this offering and private placement by reducing the
exercise prices from $0.067 per share to $0.018 per share. |
The Company accounted for the reduced
in the warrants exercise price as issuance costs to be recorded in the Company’s additional paid in capital in accordance with ASC-815.
| 3. | During the six months ended June 30, 2023, certain investors exercised
pre-funded warrants and purchased 319,091,100 of the Company’s ordinary shares for an exercise price at an immaterial amount. |
On May 1, 2023, the Company’s
board of directors approved a grant of 15,500,000 unlisted options exercisable into 15,500,000 of the Company’s ordinary shares
to the Company’s employees for an exercise price of NIS 0.026 per share and 40,000,000 unlisted options exercisable into 40,000,000
of the Company’s ordinary shares to the Company’s directors and chairman of the board of directors (subject to shareholders’
approval which was obtained on August 7, 2023, subsequent to balance sheet date) for an exercise price of NIS 0.026 per share.
The options will vest on a quarterly
basis for a period of 4 years from the date of grant. In addition, the Company’s board of
directors has also approved the increase of the options pool reserved under the Plan for issuance of ordinary share by 50,000,000 additional
options to a total of 85,000,000. As of June 30, 2023, 42,523,000 options are available for a future grant.
The following table lists the number
of share options and their weighted average exercise prices in option plans of employees, directors and consultants for the six months
period ended June 30, 2023 and related information:
| |
Number of options | | |
Weighted average exercise price | | |
Weighted
average
remaining
contractual
terms
(in years) | | |
Aggregate
intrinsic
value | |
| |
| | |
| | |
| | |
| |
Outstanding at December 31, 2022 | |
| 27,002,200 | | |
| 0.13 | | |
| 7.14 | | |
| - | |
Grants | |
| 15,500,000 | | |
| 0.01 | | |
| - | | |
| - | |
Forfeited/expired | |
| (25,200 | ) | |
| 4.05 | | |
| - | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Outstanding at June 30, 2023 | |
| 42,477,000 | | |
| 0.08 | | |
| 7.83 | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Vested and expected to vest at June 30, 2023 | |
| 42,477,000 | | |
| 0.08 | | |
| 7.83 | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Exercisable at June 30, 2023 | |
| 14,217,625 | | |
| 0.17 | | |
| 6.61 | | |
| - | |
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v3.23.2
Fair Value Measurements (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Fair Value Measurements [Abstract] |
|
Schedule of Financial Assets and Liabilities Measured at Fair Value |
The Company’s financial assets and
liabilities measured at fair value on a recurring basis, consisted of the following types of instruments as of the following dates: instruments
as of the following dates:
| |
June 30, 2023 | |
| |
Fair value measurements | |
Description | |
Fair value | | |
Level 1 | | |
Level 2 | | |
Level 3 | |
| |
| | |
| | |
| | |
| |
Short-term equity investment | |
$ | 11 | | |
$ | 11 | | |
$ | - | | |
$ | - | |
| |
December 31, 2022 | |
| |
Fair value measurements | |
Description | |
Fair value | | |
Level 1 | | |
Level 2 | | |
Level 3 | |
| |
| | |
| | |
| | |
| |
Short-term equity investment | |
$ | 8 | | |
$ | 8 | | |
$ | - | | |
$ | - | |
|
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v3.23.2
Earning Per Share (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Earnings Per Share [Abstract] |
|
Schedule of Computation of Basic and Diluted Net Loss Per Share |
The following table sets forth the
computation of basic and diluted net loss per share for the periods presented:
| |
Six month ended
June 30, | |
| |
2023 | | |
2022 | |
| |
| | |
| |
Numerator: | |
| | |
| |
Net loss applicable to shareholders of ordinary shares | |
$ | (4,220 | ) | |
$ | (4,625 | ) |
| |
| | | |
| | |
Denominator: | |
| | | |
| | |
Weighted average shares used in computing basic and diluted net loss per share | |
| 1,202,110,110 | | |
| 815,746,293 | |
Net loss per share of ordinary share, basic and diluted | |
$ | (0.00 | ) | |
$ | (0.00 | ) |
|
Schedule of Computation of Diluted Net Loss Per Share Attributable to Ordinary Shareholders |
The potential shares of ordinary shares
that were excluded from the computation of diluted net loss per share attributable to ordinary shareholders for the periods presented
because including them would have been anti-dilutive are as follows:
| |
Six month ended
June 30,
2023 | | |
Six month ended
June 30,
2022 | |
| |
| | |
| |
Options | |
| 42,477,000 | | |
| 19,256,200 | |
| |
| | | |
| | |
Warrants | |
| 1,222,016,340 | | |
| 377,947,640 | |
| |
| | | |
| | |
Total | |
| 1,264,493,340 | | |
| 397,203,840 | |
|
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v3.23.2
Shareholders Equity (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Shareholders Equity [Abstract] |
|
Schedule of Share Options and Their Weighted Average Exercise Price |
The following table lists the number
of share options and their weighted average exercise prices in option plans of employees, directors and consultants for the six months
period ended June 30, 2023 and related information:
| |
Number of options | | |
Weighted average exercise price | | |
Weighted
average
remaining
contractual
terms
(in years) | | |
Aggregate
intrinsic
value | |
| |
| | |
| | |
| | |
| |
Outstanding at December 31, 2022 | |
| 27,002,200 | | |
| 0.13 | | |
| 7.14 | | |
| - | |
Grants | |
| 15,500,000 | | |
| 0.01 | | |
| - | | |
| - | |
Forfeited/expired | |
| (25,200 | ) | |
| 4.05 | | |
| - | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Outstanding at June 30, 2023 | |
| 42,477,000 | | |
| 0.08 | | |
| 7.83 | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Vested and expected to vest at June 30, 2023 | |
| 42,477,000 | | |
| 0.08 | | |
| 7.83 | | |
| - | |
| |
| | | |
| | | |
| | | |
| | |
Exercisable at June 30, 2023 | |
| 14,217,625 | | |
| 0.17 | | |
| 6.61 | | |
| - | |
|
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v3.23.2
Earning Per Share (Details) - Schedule of Computation of Diluted Net Loss Per Share Attributable to Ordinary Shareholders - shares
|
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Total |
1,264,493,340
|
397,203,840
|
Options [Member] |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Options |
42,477,000
|
19,256,200
|
Warrants [Member] |
|
|
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |
|
|
Warrants |
1,222,016,340
|
377,947,640
|
X |
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v3.23.2
Shareholders Equity (Details) $ / shares in Units, $ in Thousands |
|
|
|
6 Months Ended |
Aug. 07, 2023
₪ / shares
|
May 01, 2023
₪ / shares
shares
|
Jan. 11, 2023
$ / shares
shares
|
Jun. 30, 2023
USD ($)
$ / shares
shares
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Aggregate ordinary shares |
|
|
90,000,000
|
180,000,000
|
Exercise price | (per share) |
₪ 0.026
|
₪ 0.026
|
|
$ 0.018
|
Purchase of warrant |
|
|
|
109,091,100
|
Warrant exercise price (in Dollars per share) | $ / shares |
|
|
|
$ 0.022
|
Placement agent warrants |
|
|
|
28,636,500
|
Issuance costs (in Dollars) | $ |
|
|
|
$ 973
|
Exercised pre-funded warrants |
|
|
|
319,091,100
|
Unlisted options exercisable price |
|
15,500,000
|
|
|
Exercisable ordinary shares |
|
40,000,000
|
|
|
Period of grant |
|
|
|
4 years
|
Issuance of ordinary share |
|
|
|
85,000,000
|
Future grant shares |
|
|
|
42,523,000
|
Pre-funded Warrants [Member] |
|
|
|
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Aggregate ordinary shares |
|
|
210,000,000
|
|
Exercise price | $ / shares |
|
|
$ 0.018
|
|
Series A [Member] |
|
|
|
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Purchase of warrant |
|
|
300,000,000
|
109,091,100
|
Warrant exercise price (in Dollars per share) | $ / shares |
|
|
$ 0.02
|
$ 0.02
|
Issuance costs (in Dollars) | $ |
|
|
|
$ 6,526
|
Series B [Member] |
|
|
|
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Purchase of warrant |
|
|
300,000,000
|
109,091,100
|
Warrant exercise price (in Dollars per share) | $ / shares |
|
|
$ 0.018
|
$ 0.018
|
Issuance costs (in Dollars) | $ |
|
|
|
$ 6,526
|
Maximum [Member] |
|
|
|
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Exercise price per share (in Dollars per share) | $ / shares |
|
|
|
$ 0.067
|
Minimum [Member] |
|
|
|
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Exercise price per share (in Dollars per share) | $ / shares |
|
|
|
$ 0.018
|
RD Shares [Member] |
|
|
|
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Purchase price (in Dollars per share) | $ / shares |
|
|
$ 0.018
|
|
Board of Directors Chairman [Member] |
|
|
|
|
Shareholders Equity (Details) [Line Items] |
|
|
|
|
Unlisted options exercisable price |
|
15,500,000
|
|
|
Exercisable ordinary shares |
|
40,000,000
|
|
|
Issuance of ordinary share |
|
|
|
50,000,000
|
X |
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v3.23.2
Shareholders Equity (Details) - Schedule of Share Options and Their Weighted Average Exercise Price
|
6 Months Ended |
Jun. 30, 2023
USD ($)
$ / shares
shares
|
Schedule of Share Options and Their Weighted Average Exercise Price [Abstract] |
|
Number of options, Beginning | shares |
27,002,200
|
Weighted average exercise price, Beginning | $ / shares |
$ 0.13
|
Weighted average remaining contractual terms, Beginning |
7 years 1 month 20 days
|
Aggregate intrinsic value, Beginning | $ |
|
Number of options, Grants | shares |
15,500,000
|
Weighted average exercise price, Grants | $ / shares |
$ 0.01
|
Number of options, Forfeited/expired | shares |
(25,200)
|
Weighted average exercise price, Forfeited/expired | $ / shares |
$ 4.05
|
Number of options, Ending | shares |
42,477,000
|
Weighted average exercise price, Ending | $ / shares |
$ 0.08
|
Weighted average remaining contractual terms, Ending |
7 years 9 months 29 days
|
Aggregate intrinsic value, Ending | $ |
|
Number of options, Vested and expected to vest | shares |
42,477,000
|
Weighted average exercise price, Vested and expected to vest | $ / shares |
$ 0.08
|
Weighted average remaining contractual terms, Vested and expected to vest |
7 years 9 months 29 days
|
Aggregate intrinsic value, Vested and expected to vest | $ |
|
Number of options, Exercisable | shares |
14,217,625
|
Weighted average exercise price, Exercisable | $ / shares |
$ 0.17
|
Weighted average remaining contractual terms, Exercisable |
6 years 7 months 9 days
|
Aggregate intrinsic value, Exercisable | $ |
|
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Can Fite BioPharma (AMEX:CANF)
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