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cs
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 10-Q
(Mark One)
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☒ |
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the quarterly period ended June 30, 2024
OR
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☐ |
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the transition period from to
Commission File Number: 001-38942
ARCTURUS THERAPEUTICS HOLDINGS INC.
(Exact Name of Registrant as Specified in its Charter)
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Delaware |
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32-0595345 |
(State or other jurisdiction of incorporation or organization) |
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(I.R.S. Employer Identification No.) |
10628 Science Center Drive, Suite 250 San Diego, California |
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92121 |
(Address of principal executive offices) |
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(Zip Code) |
(858) 900-2660
(Registrant’s telephone number, including area code)
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
Common Stock, par value $0.001 per share |
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ARCT |
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The NASDAQ Stock Market LLC |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Large accelerated filer |
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☐ |
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Accelerated filer |
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☒ |
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Non-accelerated filer |
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☐ |
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Smaller reporting company |
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☐ |
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Emerging growth company |
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☐ |
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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
As of August 2, 2024, the registrant had 27,042,246 shares of voting common stock outstanding.
ARCTURUS THERAPEUTICS HOLDINGS INC. AND ITS SUBSIDIARIES
TABLE OF CONTENTS
Special Note Regarding Forward-Looking Statements
This Quarterly Report on Form 10-Q (this “Quarterly Report”), including the section entitled “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” and the documents incorporated by reference herein may contain express or implied “forward-looking statements” within the meaning of the federal securities laws, Section 27A of the Securities Act of 1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Our actual results could differ materially from those anticipated in these forward-looking statements as a result of various factors, including those set forth below under Part II, Item 1A, “Risk Factors” in this Quarterly Report. Except as required by law, we assume no obligation to update these forward-looking statements, whether as a result of new information, future events or otherwise. These statements, which represent our current expectations or beliefs concerning various future events, may contain words such as “may,” “will,” “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate” or other words indicating future results, though not all forward-looking statements necessarily contain these identifying words. Such statements may include, but are not limited to, statements concerning the following:
•our compliance, and ability to remain in compliance, with the requirements of our collaboration agreements, including our collaboration with Seqirus Inc. (“CSL Seqirus”);
•the anticipated benefits and success of our collaboration agreement with CSL Seqirus related to the licensure of our STARR® mRNA technology and LUNAR® lipid-mediated delivery, including our timely receipt of upfront and potential royalty and other payments thereunder;
•the continued development activities of the LUNAR-COV19 and LUNAR-FLU programs under our collaboration with CSL Seqirus;
•the status, success and benefits of our arrangements with private and governmental entities, some of which are subject to termination for convenience by our counterparties;
•our compliance, and ability to remain in compliance, with the stringent requirements of our current and potential government contracts, including our arrangements with the Biomedical Advanced Research and Development Authority, a division of the Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services and the Department of Defense;
•our plans to conduct and advance any of our research programs;
•the initiation, design, cost, timing, progress, enrollment and results of, and our expected ability to undertake certain activities and accomplish certain goals with respect to, our research and development activities, preclinical studies and clinical trials, including those related to our therapeutics pipeline candidates ARCT-810 and ARCT-032;
•the potential safety, immunogenicity, efficacy or regulatory approval of any of our product candidates;
•the potential safety, immunogenicity, efficacy or regulatory approval of any of our COVID-19 vaccine candidates as a booster or primary vaccination series;
•the potential effects and benefits of our technologies and product candidates on their own and in comparison to technologies, drugs or courses of treatment currently available or that may be developed by competitors;
•the likelihood that preclinical or clinical data will be predictive of future clinical results or efficacy or safety of a product candidate;
•the anticipated timing of enrollment, duration, milestones and announcements of results of clinical trials, and the submission of applications to conduct clinical trials;
•the likelihood that clinical data will be sufficient for regulatory approval or completed in time to submit an application for regulatory approval within a particular timeframe;
•the likelihood or timing of any regulatory approval, and the likelihood that the marketing approval of ARCT-154 in Japan will be predictive of any future marketing approvals in other countries or for other versions of our LUNAR-COV19 or other product candidates or of any commercial sales;
•the potential administration regimen or dosage, or ability to administer multiple doses of, any of our product candidates;
•our ability to obtain and maintain regulatory approval of our product candidates, and any related restrictions, limitations, and/or warnings in the label of an approved product candidate;
•our plans to develop and commercialize our product candidates;
•our ability to successfully commercialize, and our expectations regarding future therapeutic and commercial potential with respect to, our product candidates;
•the rate and degree of market acceptance of our product candidates;
•the success of competing therapies that are or may become available;
•the size and growth potential of the markets for our product candidates, and our ability to serve those markets and address unmet medical needs;
•our ability to obtain and maintain intellectual property protection for our product candidates;
•interactions with regulatory authorities in the United States and foreign countries;
•our ability to attract and retain experienced and seasoned scientific and management professionals;
•the performance of our third-party suppliers and manufacturers, including our ability to scale-up manufacturing levels as necessary;
•our strategic alliance partners’ election to pursue development and commercialization of any programs or product candidates that are subject to our collaboration and license agreements with such partners;
•our ability to attract collaborators with relevant development, regulatory and commercialization expertise;
•future activities to be undertaken by our strategic alliance partners, collaborators and other third parties;
•our ability to develop sales and marketing capabilities, whether alone or with potential future collaborators;
•our ability to avoid, settle or be victorious at costly litigation with shareholders, former executives or others, should these situations arise;
•our ability to obtain and deploy funding for our operations and to efficiently use our financial and other resources;
•our ability to continue as a going concern; and
•the accuracy of our estimates regarding future expenses, future revenues, cash flows, capital requirements need for additional financing, and possible sources of revenue.
These and other forward-looking statements are only current predictions and are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry’s actual results, levels of activity, performance or achievements to be materially different from those anticipated by the forward-looking statements. In addition, historic results of scientific research, preclinical and clinical trials do not guarantee that future research or trials will suggest the same conclusions, nor that historic results referred to herein will be interpreted in the same manner due to additional research, preclinical and clinical trial results or otherwise. The forward-looking statements contained in this Quarterly Report are subject to risks and uncertainties, including those discussed in our other filings with the United States Securities and Exchange Commission (the “Commission”). Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof unless specifically stated otherwise. Although we currently believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance, or achievements.
PART I—FINANCIAL INFORMATION
Item 1. Financial Statements.
ARCTURUS THERAPEUTICS HOLDINGS INC. AND ITS SUBSIDIARIES
CONDENSED CONSOLIDATED BALANCE SHEETS
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June 30, 2024 |
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December 31, 2023 |
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(in thousands, except par value information) |
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(unaudited) |
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Assets |
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Current assets: |
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Cash and cash equivalents |
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$ |
260,329 |
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$ |
292,005 |
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Restricted cash |
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55,000 |
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55,000 |
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Accounts receivable |
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24,085 |
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32,064 |
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Prepaid expenses and other current assets |
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7,594 |
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7,521 |
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Total current assets |
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347,008 |
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386,590 |
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Property and equipment, net |
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11,182 |
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12,427 |
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Operating lease right-of-use assets, net |
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28,533 |
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28,500 |
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Non-current restricted cash |
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1,885 |
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1,885 |
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Total assets |
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$ |
388,608 |
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$ |
429,402 |
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Liabilities and stockholders’ equity |
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Current liabilities: |
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Accounts payable |
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$ |
13,905 |
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$ |
5,279 |
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Accrued liabilities |
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35,450 |
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31,881 |
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Deferred revenue |
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42,362 |
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44,829 |
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Total current liabilities |
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91,717 |
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81,989 |
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Deferred revenue, net of current portion |
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11,344 |
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42,496 |
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Operating lease liability, net of current portion |
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26,964 |
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25,907 |
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Other non-current liabilities |
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— |
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497 |
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Total liabilities |
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130,025 |
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150,889 |
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Stockholders’ equity |
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Common stock, $0.001 par value; 60,000 shares authorized; issued and outstanding shares were 27,042 at June 30, 2024 and 26,828 at December 31, 2023 |
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27 |
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27 |
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Additional paid-in capital |
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670,455 |
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646,352 |
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Accumulated deficit |
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(411,899 |
) |
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(367,866 |
) |
Total stockholders’ equity |
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258,583 |
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278,513 |
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Total liabilities and stockholders’ equity |
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$ |
388,608 |
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$ |
429,402 |
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The accompanying notes are an integral part of these condensed consolidated financial statements.
ARCTURUS THERAPEUTICS HOLDINGS INC. AND ITS SUBSIDIARIES
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
(unaudited)
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Three Months Ended |
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Six Months Ended |
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June 30, |
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June 30, |
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(in thousands, except per share data) |
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2024 |
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2023 |
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2024 |
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2023 |
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Revenue: |
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Collaboration revenue |
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$ |
45,976 |
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$ |
9,565 |
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$ |
78,574 |
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$ |
89,294 |
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Grant revenue |
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3,883 |
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954 |
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9,297 |
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1,510 |
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Total revenue |
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49,859 |
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10,519 |
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87,871 |
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90,804 |
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Operating expenses: |
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Research and development, net |
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58,669 |
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52,668 |
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112,242 |
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104,436 |
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General and administrative |
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12,316 |
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13,225 |
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27,167 |
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26,987 |
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Total operating expenses |
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70,985 |
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65,893 |
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139,409 |
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131,423 |
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Loss from operations |
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(21,126 |
) |
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(55,374 |
) |
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(51,538 |
) |
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(40,619 |
) |
(Loss) gain from foreign currency |
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(388 |
) |
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149 |
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(441 |
) |
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(179 |
) |
Gain on debt extinguishment |
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— |
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— |
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— |
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33,953 |
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Finance income, net |
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4,148 |
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3,252 |
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8,164 |
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5,729 |
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Net loss before income taxes |
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|
(17,366 |
) |
|
|
(51,973 |
) |
|
|
(43,815 |
) |
|
|
(1,116 |
) |
Provision for income taxes |
|
|
(150 |
) |
|
|
577 |
|
|
|
218 |
|
|
|
680 |
|
Net loss |
|
$ |
(17,216 |
) |
|
$ |
(52,550 |
) |
|
$ |
(44,033 |
) |
|
$ |
(1,796 |
) |
Net loss per share, basic and diluted |
|
$ |
(0.64 |
) |
|
$ |
(1.98 |
) |
|
$ |
(1.64 |
) |
|
$ |
(0.07 |
) |
Weighted-average shares outstanding, basic and diluted |
|
|
26,967 |
|
|
|
26,563 |
|
|
|
26,923 |
|
|
|
26,557 |
|
Comprehensive loss: |
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(17,216 |
) |
|
$ |
(52,550 |
) |
|
$ |
(44,033 |
) |
|
$ |
(1,796 |
) |
Comprehensive loss |
|
$ |
(17,216 |
) |
|
$ |
(52,550 |
) |
|
$ |
(44,033 |
) |
|
$ |
(1,796 |
) |
The accompanying notes are an integral part of these condensed consolidated financial statements.
ARCTURUS THERAPEUTICS HOLDINGS INC. AND ITS SUBSIDIARIES
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
(unaudited)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional |
|
|
|
|
|
Total |
|
|
|
Common Stock |
|
|
Paid-In |
|
|
Accumulated |
|
|
Stockholders’ |
|
(in thousands) |
|
Shares |
|
|
Amount |
|
|
Capital |
|
|
Deficit |
|
|
Equity |
|
Balance at December 31, 2023 |
|
|
26,828 |
|
|
$ |
27 |
|
|
$ |
646,352 |
|
|
$ |
(367,866 |
) |
|
$ |
278,513 |
|
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(26,817 |
) |
|
|
(26,817 |
) |
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
10,088 |
|
|
|
— |
|
|
|
10,088 |
|
Issuance of common stock upon exercise of stock options |
|
|
89 |
|
|
|
— |
|
|
|
2,188 |
|
|
|
— |
|
|
|
2,188 |
|
Balance at March 31, 2024 |
|
|
26,917 |
|
|
$ |
27 |
|
|
$ |
658,628 |
|
|
$ |
(394,683 |
) |
|
$ |
263,972 |
|
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(17,216 |
) |
|
|
(17,216 |
) |
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
9,424 |
|
|
|
— |
|
|
|
9,424 |
|
Issuance of common stock upon exercise of stock options |
|
|
125 |
|
|
|
— |
|
|
|
2,403 |
|
|
|
— |
|
|
|
2,403 |
|
Balance at June 30, 2024 |
|
|
27,042 |
|
|
$ |
27 |
|
|
$ |
670,455 |
|
|
$ |
(411,899 |
) |
|
$ |
258,583 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional |
|
|
|
|
|
Total |
|
|
|
Common Stock |
|
|
Paid-In |
|
|
Accumulated |
|
|
Stockholders’ |
|
(in thousands) |
|
Shares |
|
|
Amount |
|
|
Capital |
|
|
Deficit |
|
|
Equity |
|
Balance at December 31, 2022 |
|
|
26,555 |
|
|
$ |
27 |
|
|
$ |
608,426 |
|
|
$ |
(338,141 |
) |
|
$ |
270,312 |
|
Net income |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
50,754 |
|
|
|
50,754 |
|
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
8,182 |
|
|
|
— |
|
|
|
8,182 |
|
Balance at March 31, 2023 |
|
|
26,555 |
|
|
$ |
27 |
|
|
$ |
616,608 |
|
|
$ |
(287,387 |
) |
|
$ |
329,248 |
|
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(52,550 |
) |
|
|
(52,550 |
) |
Share-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
8,383 |
|
|
|
— |
|
|
|
8,383 |
|
Issuance of common stock upon exercise of stock options |
|
|
19 |
|
|
|
— |
|
|
|
94 |
|
|
|
— |
|
|
|
94 |
|
Balance at June 30, 2023 |
|
|
26,574 |
|
|
$ |
27 |
|
|
$ |
625,085 |
|
|
$ |
(339,937 |
) |
|
$ |
285,175 |
|
The accompanying notes are an integral part of these condensed consolidated financial statements.
ARCTURUS THERAPEUTICS HOLDINGS INC. AND ITS SUBSIDIARIES
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(unaudited)
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
Operating activities |
|
|
|
|
|
|
Net loss |
|
$ |
(44,033 |
) |
|
$ |
(1,796 |
) |
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |
|
|
|
|
|
|
Depreciation and amortization |
|
|
1,813 |
|
|
|
1,315 |
|
Share-based compensation expense |
|
|
19,512 |
|
|
|
16,565 |
|
Foreign currency transaction loss |
|
|
441 |
|
|
|
160 |
|
Gain on debt extinguishment |
|
|
— |
|
|
|
(33,953 |
) |
Other non-cash expenses |
|
|
— |
|
|
|
502 |
|
Changes in assets and liabilities: |
|
|
|
|
|
|
Accounts receivable |
|
|
7,979 |
|
|
|
(35 |
) |
Prepaid expense and other assets |
|
|
(73 |
) |
|
|
4,712 |
|
Right-of-use assets |
|
|
2,703 |
|
|
|
1,992 |
|
Accounts payable |
|
|
8,626 |
|
|
|
5,593 |
|
Accrued liabilities |
|
|
2,631 |
|
|
|
(2,983 |
) |
Deferred revenue |
|
|
(33,619 |
) |
|
|
24,969 |
|
Lease liabilities |
|
|
(1,679 |
) |
|
|
(2,105 |
) |
Net cash (used in) provided by operating activities |
|
|
(35,699 |
) |
|
|
14,936 |
|
Investing activities |
|
|
|
|
|
|
Acquisition of property and equipment |
|
|
(568 |
) |
|
|
(1,045 |
) |
Net cash used in investing activities |
|
|
(568 |
) |
|
|
(1,045 |
) |
Financing activities |
|
|
|
|
|
|
Proceeds from exercise of stock options |
|
|
4,591 |
|
|
|
94 |
|
Payments on debt obligations |
|
|
— |
|
|
|
(27,364 |
) |
Net cash provided by (used in) financing activities |
|
|
4,591 |
|
|
|
(27,270 |
) |
Net decrease in cash, cash equivalents and restricted cash |
|
|
(31,676 |
) |
|
|
(13,379 |
) |
Cash, cash equivalents and restricted cash at beginning of the period |
|
|
348,890 |
|
|
|
393,977 |
|
Cash, cash equivalents and restricted cash at end of the period |
|
$ |
317,214 |
|
|
$ |
380,598 |
|
|
|
|
|
|
|
|
|
|
|
|
Six Months Ended June 30, |
|
|
|
2024 |
|
|
2023 |
|
Supplemental disclosure of cash flow information |
|
|
|
|
|
|
Cash paid for interest |
|
$ |
— |
|
|
$ |
2,102 |
|
Non-cash investing activities |
|
|
|
|
|
|
Non-cash asset disposal |
|
$ |
473 |
|
|
$ |
— |
|
Right-of-use assets acquired through operating leases |
|
$ |
2,736 |
|
|
$ |
— |
|
Purchase of property and equipment in accounts payable |
|
$ |
— |
|
|
$ |
577 |
|
|
|
|
|
|
|
|
The accompanying notes are an integral part of these condensed consolidated financial statements.
ARCTURUS THERAPEUTICS HOLDINGS INC. AND ITS SUBSIDIARIES
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(Unaudited)
Note 1. Description of Business, Basis of Presentation and Summary of Significant Accounting Policies
Description of Business
Arcturus Therapeutics Holdings Inc. (the “Company” or "Arcturus") is a global messenger RNA medicines company focused on the development of infectious disease vaccines and significant addressing unmet medical needs within liver and respiratory rare diseases. The Company became a clinical stage company during 2020 when it announced that its Investigational New Drug (“IND”) application for ornithine transcarbamylase (“OTC”) deficiency and its Clinical Trial Application (“CTA”) for candidate LUNAR-COV19 were approved by applicable health authorities.
Basis of Presentation
The accompanying condensed consolidated financial statements include the accounts of Arcturus and its subsidiaries and are unaudited. All intercompany accounts and transactions have been eliminated in consolidation. These condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, the accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.
Interim financial results are not necessarily indicative of results anticipated for the full year. These condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2023.
These condensed consolidated financial statements are prepared in accordance with GAAP, which requires management to make estimates and assumptions regarding the valuation of certain debt and equity instruments, share-based compensation, accruals for liabilities, income taxes, revenue and deferred revenue, leases, and other matters that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting periods. Although these estimates are based on management’s knowledge of current events and actions the Company may undertake in the future, actual results may ultimately differ from these estimates and assumptions.
Joint Ventures, Equity Method Investments and Variable Interest Entities
Investments for which the Company exercises significant influence, but does not have control are accounted for under the equity method. Equity method investment activity is related to the Company's joint venture in ARCALIS, Inc. with Axcelead, Inc. (“Axcelead”). The Company’s share of the investee's results is presented as either income or loss from equity-method investment in the accompanying condensed consolidated statements of operations and comprehensive loss.
Liquidity
The Company has incurred significant operating losses since its inception. As of June 30, 2024 and December 31, 2023, the Company had an accumulated deficit of $411.9 million and $367.9 million, respectively.
The Company’s activities since inception have consisted principally of research and development activities, general and administrative activities, and raising capital. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before the Company achieves sustainable revenues and profit from operations. From the Company’s inception through June 30, 2024, the Company has funded its operations principally with the proceeds from revenues earned through collaboration agreements, the sale of capital stock, expense reimbursements from government contracts and proceeds from long-term debt. At June 30, 2024, the Company’s balance of cash and cash equivalents, including restricted cash, was $317.2 million.
Management believes that it has sufficient working capital on hand to fund operations through at least the next twelve months from the date these condensed consolidated financial statements were available to be issued. There can be no assurance that the Company will be successful in securing additional funding, that the Company’s projections of its future working capital needs will prove accurate, or that any additional funding would be sufficient to continue operations in future years.
Segment Information
Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance. The Company and its chief operating decision-maker view the Company’s operations and manage its business in one operating segment, which is the research and development of medical applications for the Company’s nucleic acid-focused technology.
Revenue Recognition
At contract inception, the Company analyzes its collaboration arrangements to assess whether such arrangements involve joint operating activities performed by parties that are both active participants in the activities and exposed to significant risks and rewards dependent on the commercial success of such activities and therefore within the scope of Accounting Standards Codification (“ASC”) Topic 808, Collaborative Arrangements (“ASC 808”). For collaboration arrangements within the scope of ASC 808 that contain multiple elements, the Company first determines which elements of the collaboration reflect a vendor-customer relationship and are therefore within the scope of ASC 606.
The Company determines revenue recognition for arrangements within the scope of ASC 606 by performing the following five steps: (i) identify the contract; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when, or as, the company satisfies a performance obligation.
The terms of the Company’s revenue agreements include license fees, upfront payments, development or regulatory milestone payments, profit-sharing arrangements, reimbursement for research and development activities, option exercise fees, drug substance and drug product supply fees, consulting and related technology transfer fees and royalties on sales of commercialized products. The event-based milestone payments represent variable consideration, and the Company uses the most likely amount method to estimate this variable consideration because the Company will either receive the milestone payment or will not, which makes the potential milestone payment a binary event. The most likely amount method requires the Company to determine the likelihood of earning the milestone payment. Given the high degree of uncertainty around achievement of these milestones, the Company determines the milestone amounts to be fully constrained and does not recognize revenue until the uncertainty associated with these payments is resolved. The Company will recognize revenue from sales-based royalty payments when or as the sales occur. The Company will re-evaluate the transaction price in each reporting period as uncertain events are resolved and other changes in circumstances occur.
A performance obligation is a promise in a contract to transfer a distinct good or service to the collaborative partner and is the unit of account in ASC 606. A contract’s transaction price is allocated to each distinct performance obligation based on relative standalone selling price and recognized as revenue when, or as, the performance obligation is satisfied.
For performance obligations that are recognized over time, the Company measures the progress using an input method. The input methods used are based on the effort expended or costs incurred toward the satisfaction of the performance obligation. The Company estimates the amount of effort expended, including the time estimated it will take to complete the activities, or costs incurred in a given period, relative to the estimated total effort or costs to satisfy the performance obligation. This approach requires the Company to make numerous estimates and use significant judgment. If estimates or judgments change over the course of the collaboration, a cumulative catch up of revenue is recognized in the period such changes are identified.
See “Note 2, Revenue” for specific details surrounding the Company’s arrangements.
Leases
The Company determines if an arrangement is a lease at inception. Lease right-of-use assets represent the Company's right to use an underlying asset for the lease term and lease liabilities represent the Company's obligation to make lease payments arising from the lease. For operating leases with an initial term greater than 12 months, the Company recognizes operating lease right-of-use assets and operating lease liabilities based on the present value of lease payments over the lease term at the commencement date. Operating lease right-of-use assets are comprised of the lease liability plus any lease payments made and excludes lease incentives. Lease terms include options to renew or terminate the lease when the Company is reasonably certain that the renewal option will be exercised or when it is reasonably certain that the termination option will not be exercised. For the Company's operating leases, if the interest rate used to determine the present value of future lease payments is not readily determinable, the Company estimates its incremental borrowing rate as the discount rate for the lease. The Company's incremental borrowing rate is estimated to approximate the interest rate on a collateralized basis with similar terms and payments, and in similar economic environments. Lease expense for lease payments is recognized on a straight-line basis over the lease term. The Company has elected the practical expedient to not separate lease and non-lease components.
See “Note 9, Commitments and Contingencies” for specific details surrounding the Company’s leases.
Research and Development Costs, Net
All research and development costs are expensed as incurred. Research and development costs consist primarily of salaries, employee benefits, costs associated with preclinical studies and clinical trials (including amounts paid to clinical research organizations and other professional services), in-process research and development expenses, pre-launch inventory and license agreement expenses. Research and development expenses are presented net of any grants. Payments made prior to the receipt of goods or services to be used in research and development are capitalized until the goods are received or the services are performed.
The Company records accruals for estimated research and development costs, comprising payments for work performed by third party contractors, laboratories, participating clinical trial sites, and others. Some of these contractors bill monthly based on actual services performed, while others bill periodically based upon achieving certain contractual milestones. For the latter, the Company accrues the expenses as goods or services are used or rendered.
Clinical trial activities performed by third parties are accrued and expensed based upon estimates of the proportion of work completed over the life of the individual clinical trial and patient enrollment rates in accordance with agreements established with Clinical Research Organizations ("CROs") and clinical trial sites. Estimates are determined by reviewing contracts, vendor agreements and purchase orders, and through discussions with internal clinical personnel and external service providers as to the progress or stage of completion of trials or services and the agreed-upon fee to be paid for such services.
Pre-Launch Inventory
Prior to obtaining initial regulatory approval for an investigational product candidate, the Company expenses costs relating to production of inventory as research and development expense in its condensed consolidated statements of operations and comprehensive loss, in the period incurred. When the Company believes regulatory approval and subsequent commercialization of an investigational product candidate is probable, and the Company also expects future economic benefit from the sales of the investigational product candidate to be realized, it will then capitalize the costs of production as inventory.
Restricted Cash
Restricted cash includes collateral pledged and held at the Company’s securities accounts pursuant to a security agreement with Wells Fargo Bank, National Association (“Wells Fargo”) (Note 5). At June 30, 2024, such collateral amounted to $55.0 million.
Restricted cash also includes cash required to be set aside as security for lease payments and to maintain a letter of credit for the benefit of the landlord for the Company’s offices. At June 30, 2024 and 2023, the Company had restricted cash of $1.9 million and $2.1 million, respectively, in conjunction with property leases in San Diego, California, and such restriction is expected to be removed at the end of the lease term.
The following table provides a reconciliation of cash and cash equivalents and restricted cash reported within the unaudited condensed consolidated balance sheets that sum to the total of the same such amounts shown in the unaudited condensed consolidated statement of cash flows as of June 30, 2024 and 2023:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
June 30, 2023 |
|
Cash and cash equivalents |
|
$ |
260,329 |
|
|
$ |
323,471 |
|
Restricted cash |
|
|
55,000 |
|
|
|
55,000 |
|
Non-current restricted cash |
|
|
1,885 |
|
|
|
2,127 |
|
Total cash, cash equivalents and restricted cash shown in the statement of cash flows |
|
$ |
317,214 |
|
|
$ |
380,598 |
|
Net Loss per Share
Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period, without consideration for common stock equivalents. Diluted net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock and dilutive common stock equivalents outstanding for the period determined using the treasury-stock method. Dilutive shares of common stock for the three and six months ended June 30, 2024 were comprised of stock options and restricted stock units. Dilutive shares of common stock for the three and six months ended June 30, 2023 were comprised of stock options.
No dividends were declared or paid during the reported periods.
Recently Issued Accounting Standards Not Yet Adopted
From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board or other standard setting bodies and adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on the condensed consolidated financial statements and disclosures.
Note 2. Revenue
The Company has entered into license agreements and collaborative research and development arrangements with pharmaceutical and biotechnology companies, as well as consulting, related technology transfer, product revenue and government grant agreements. Under these arrangements, the Company is entitled to receive license fees, consulting fees, product fees, technological transfer fees, upfront payments, milestone payments if and when certain research and development milestones, technology transfer milestones or success-based milestones are achieved, royalties on approved product sales and reimbursement for research and development activities. The Company’s costs of performing these services are included within research and development expenses. The Company’s milestone payments are typically defined by achievement of certain preclinical, clinical, and commercial success criteria. Preclinical milestones may include in vivo proof of concept in disease animal models, lead candidate identification, and completion of IND-enabling toxicology studies. Clinical milestones may, for example, include successful enrollment of the first patient in or completion of Phase 1, 2 and 3 clinical trials, and commercial milestones are often tiered based on net or aggregate sale amounts. The Company cannot guarantee the achievement of these milestones due to risks associated with preclinical and clinical activities required for development of nucleic acid medicine-based therapeutics and vaccines.
The following table presents changes during the six months ended June 30, 2024 in the balances of contract assets and liabilities as compared to what was disclosed in the Company’s Annual Report.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(in thousands) |
|
December 31, 2023 |
|
|
Additions |
|
|
Deductions |
|
|
June 30, 2024 |
|
Contract Assets: |
|
|
|
|
|
|
|
|
|
|
|
|
Accounts receivable |
|
$ |
32,064 |
|
|
$ |
55,132 |
|
|
$ |
(63,111 |
) |
|
$ |
24,085 |
|
Contract Liabilities: |
|
|
|
|
|
|
|
|
|
|
|
|
Deferred revenue |
|
$ |
87,325 |
|
|
$ |
54,252 |
|
|
$ |
(87,871 |
) |
|
$ |
53,706 |
|
The following table summarizes the Company’s revenues for the periods indicated.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Three Months Ended June 30, |
|
|
For the Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Collaboration Revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
CSL Seqirus |
|
$ |
45,911 |
|
|
$ |
7,607 |
|
|
$ |
78,292 |
|
|
$ |
85,824 |
|
Janssen |
|
|
— |
|
|
|
170 |
|
|
|
— |
|
|
|
660 |
|
Other collaboration revenue |
|
|
65 |
|
|
|
1,788 |
|
|
|
282 |
|
|
|
2,810 |
|
Total collaboration revenue |
|
$ |
45,976 |
|
|
$ |
9,565 |
|
|
$ |
78,574 |
|
|
$ |
89,294 |
|
Grant revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
BARDA |
|
$ |
3,883 |
|
|
$ |
954 |
|
|
$ |
9,297 |
|
|
$ |
1,510 |
|
Total grant revenue |
|
$ |
3,883 |
|
|
$ |
954 |
|
|
$ |
9,297 |
|
|
$ |
1,510 |
|
The following paragraphs provide information regarding the nature and purpose of the Company’s most significant collaboration and grant arrangements.
CSL Seqirus
On November 1, 2022, the Company entered into a Collaboration and License Agreement (as amended, the “CSL Collaboration Agreement”) with Seqirus, Inc., a part of CSL Limited (“CSL Seqirus”), for the global exclusive rights to research, develop, manufacture, and commercialize vaccines. Under the terms of the CSL Collaboration Agreement, the Company provides CSL Seqirus with an exclusive global license to its mRNA technology (including STARR®) and LUNAR® lipid-mediated delivery, along with mRNA drug substance and drug product manufacturing process. CSL Seqirus will lead development and commercialization of vaccines under the collaboration. The collaboration plans to advance vaccines against SARS-CoV-2 (COVID-19), influenza, pandemic preparedness as well as three other respiratory infectious diseases.
The Company received a $200.0 million upfront payment and is eligible to receive over $1.3 billion in development milestones if all products are registered in the licensed fields and entitled to potentially receive up to $3.0 billion in commercial milestones based on “net sale” of vaccines in the various fields. In addition, the Company is eligible to receive a 40% net profit share for COVID-19 vaccine products and up to low double-digit royalties for vaccines against flu, pandemic preparedness and three other respiratory pathogens. During the second quarter of 2024, the Company achieved a $17.0 million development milestone related to the CSL Collaboration Agreement which was included in accounts receivable as of June 30, 2024.
In evaluating the CSL Collaboration Agreement in accordance with ASC 606, the Company concluded that CSL Seqirus is a customer. The Company identified all promised goods/services within the CSL Collaboration Agreement, and when combining certain promised goods/services, the Company concluded that there are five distinct performance obligations. The nature of the performance obligations consists of delivery of the vaccine license, research and development services for COVID and non-COVID vaccines and regulatory activities for COVID vaccines. For each performance obligation, the Company estimated the standalone selling price based on 1) in the case of the license, the fair value using costs to recreate plus margin method and 2) in the case of research and development services and regulatory activities, cost plus margin for estimated full-time equivalent (“FTE”) costs, direct costs including laboratory supplies, contractors, and other out-of-pocket expenses for research and development services and regulatory activities.
As of June 30, 2024, the transaction price consisted of upfront consideration received and milestones achieved. Additional variable consideration was not included in the transaction price at June 30, 2024 because the Company could not conclude that it is probable that including the variable consideration will not result in a significant revenue reversal.
The Company allocated the transaction price to the performance obligations in proportion to their standalone selling price. The vaccine license was recognized at the point in time it was transferred in 2022. The research and development and regulatory activities performance obligations are recognized over a period of time based on the percentage of services rendered using the input method, meaning actual costs incurred divided by total costs budgeted to satisfy the performance obligation. Any consideration related to sales-based royalties will be recognized when the amounts are probable of non-reversal, provided that the reported sales are reliably measurable and the Company has no remaining promised goods/services, as they are constrained and therefore have also been excluded from the transaction price. The revenue recognized in the second quarter of 2024 relates to the license delivered, milestones achieved and services performed through June 30, 2024.
Total deferred revenue as of June 30, 2024 and December 31, 2023 for the CSL Collaboration Agreement was $53.7 million and $87.1 million, respectively.
During 2023, the Company also received an advance payment of $23.6 million for the manufacturing and supply of ARCT-154 drug product. The advance payment was for specified manufacturing runs of ARCT-154 which include the drug substance utilized, as well as the reservation fees and related manufacturing requirements. The Company concluded that the promise to manufacture and supply ARCT-154 drug product is a customer option as part of the CSL Collaboration Agreement and is accounted for as a separate contract. The Company recognized $18.0 million in revenue related to this customer option during the second quarter of 2024. No amount related to this customer option remained in deferred revenue as of June 30, 2024.
During 2023, the Company entered into an amendment to the CSL Collaboration Agreement, pursuant to which the Company agreed to sponsor and conduct a Phase 1 clinical study in the influenza field. As part of the amendment, the Company received $17.5 million from CSL Seqirus. The amendment also provides for up to $1.5 million in additional payments which are achievable upon meeting certain clinical milestones relating to the Phase 1 clinical study in the influenza field. The Company previously concluded that the expansion of research and development support services under the CSL Collaboration Agreement represented an option that was not a material right. Therefore the Company concluded the promise to sponsor and conduct the Phase 1 clinical study is a separate contract and the sole performance obligation under the new arrangement. During the quarter ended June 30, 2024, the Company recognized $3.0 million related to the performance obligation and the remaining amount of $9.8 million is included in deferred revenue.
During the fourth quarter of 2023, the Company received an advance payment of $5.3 million from CSL Seqirus for manufacturing activities related to COVID-19 vaccine product. During the first quarter of 2024, the Company received an additional advance payment of $5.1 million from CSL Seqirus for manufacturing activities related to COVID-19 vaccine product. The Company
concluded that the promise to perform manufacturing activities is a customer option as part of the CSL Collaboration Agreement and is accounted for as a separate contract. The advance payments are included in deferred revenue as of June 30, 2024 and will be recognized as revenue when the vaccine product is transferred to CSL Seqirus.
In March 2024, the Company entered into an amendment to the CSL Collaboration Agreement, pursuant to which the parties agreed to, among other things, adjust (i) the development plans for certain product candidates, (ii) various development milestones related to such product candidates, (iii) provisions of the CSL Collaboration Agreement related to specific royalty payments, (iii) provisions of the CSL Collaboration Agreement related to distributors, and (iv) proprietary payment calculations related to the foregoing.
BARDA Grant
In August 2022, the Company entered into a cost reimbursement contract (the “BARDA Contract”) with the Biomedical Advanced Research and Development Authority ("BARDA"), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS) for an award of up to $63.2 million for the development of a pandemic influenza vaccine using the Company's STARR® self-amplifying mRNA vaccine platform technology. The Company earns grant revenue for performing tasks under the agreement.
The Company determined that the BARDA Contract is not in the scope of ASC 808 or ASC 606. Applying International Accounting Standards No. 20 ("IAS 20"), Accounting for Government Grants and Disclosure of Government Assistance, by analogy, the Company recognizes grant revenue from the reimbursement of direct out-of-pocket expenses, overhead allocations and fringe benefits for research costs associated with the grant. The costs associated with these reimbursements are reflected as a component of research and development expense in the Company’s condensed consolidated statements of operations and comprehensive income (loss).
The Company recognized $3.9 million and $1.0 million of revenue during the three months ended June 30, 2024 and 2023, respectively. As of June 30, 2024, the remaining available funding net of revenue earned was $44.5 million.
Note 3. Fair Value Measurements
The Company establishes the fair value of its assets and liabilities using the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The Company established a fair value hierarchy based on the inputs used to measure fair value.
The three levels of the fair value hierarchy are as follows:
Level 1: Quoted prices in active markets for identical assets or liabilities.
Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly.
Level 3: Unobservable inputs in which little or no market data exists and are therefore determined using estimates and assumptions developed by the Company, which reflect those that a market participant would use.
The carrying value of cash, restricted cash, accounts receivable, accounts payable and accrued liabilities approximate their respective fair values due to their relative short maturities.
As of June 30, 2024 and December 31, 2023, all assets measured at fair value on a recurring basis consisted of cash equivalents and money market funds, which were classified within Level 1 of the fair value hierarchy. The fair value of these financial instruments was measured based on quoted prices.
Note 4. Balance Sheet Details
Property and equipment, net balances consisted of the following:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Research equipment |
|
$ |
16,784 |
|
|
$ |
16,046 |
|
Computers and software |
|
|
1,131 |
|
|
|
1,275 |
|
Office equipment and furniture |
|
|
703 |
|
|
|
958 |
|
Leasehold improvements |
|
|
2,644 |
|
|
|
2,655 |
|
Construction in progress |
|
|
— |
|
|
|
233 |
|
Total |
|
|
21,262 |
|
|
|
21,167 |
|
Less accumulated depreciation and amortization |
|
|
(10,080 |
) |
|
|
(8,740 |
) |
Property and equipment, net |
|
$ |
11,182 |
|
|
$ |
12,427 |
|
Depreciation and amortization expense was $0.9 million and $1.8 million for the three and six months ended June 30, 2024, respectively, and $0.7 million and $1.3 million for the three and six months ended June 30, 2023, respectively. Construction in progress is primarily comprised of research equipment not yet placed in service.
Accrued liabilities consisted of the following:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Accrued compensation |
|
$ |
9,206 |
|
|
$ |
5,918 |
|
Cystic Fibrosis Foundation liability |
|
|
6,870 |
|
|
|
7,633 |
|
Income tax payable |
|
|
— |
|
|
|
641 |
|
Current portion of operating lease liability |
|
|
3,917 |
|
|
|
4,309 |
|
Clinical trial accruals |
|
|
968 |
|
|
|
2,333 |
|
Vinbiocare contractual liabilities |
|
|
2,514 |
|
|
|
2,514 |
|
Other accrued research and development expenses |
|
|
11,975 |
|
|
|
8,533 |
|
Total |
|
$ |
35,450 |
|
|
$ |
31,881 |
|
Note 5. Debt
Wells Fargo Credit Agreement
The Company’s wholly-owned subsidiary, Arcturus Therapeutics, Inc. (“Arcturus Therapeutics”) entered into a credit agreement with Wells Fargo Bank on April 21, 2023, and amended on June 26, 2024, whereby Wells Fargo will make a $50.0 million revolving credit line available to the Company (the “Loan”) and each draw on the Loan evidenced by a revolving line of credit note (the “Note”).
Borrowings under the agreement will bear interest at a rate of 1.00% above either the Daily Simple SOFR or Term SOFR (as such terms are defined in the Note), with “SOFR” being the rate per annum equal to the secured overnight financing rate as administered by the Federal Reserve Bank of New York. If an Event of Default (as defined in the agreement) occurs, then all Loans shall bear interest at a rate equal to 2.00% above the interest rate applicable immediately prior to the occurrence of the Event of Default.
The term of the agreement was originally two years, with an option for one-year renewals subject to Wells Fargo approval and Arcturus Therapeutics furnishing to Wells Fargo a non-refundable commitment fee equal to 0.25% of the Loan amount for each such renewal. There is no penalty for terminating the facility prior to the maturity date of the Note. As collateral, the Company has agreed to pledge $55.0 million in cash to be held at the Company’s securities accounts with Wells Fargo Securities, LLC, an affiliate of Wells Fargo, pursuant to a security agreement. In June 2024, Arcturus Therapeutics and Wells Fargo entered into an amendment to the Note, whereby the term of the Note was extended by one year to April 2026. No borrowings were outstanding as of June 30, 2024.
Note 6. Stockholders’ Equity
Net Loss per Share
Potentially dilutive securities that were not included in the calculation of diluted net loss per share for the three and six months ended June 30, 2024 as they were anti-dilutive totaled 1.1 million and 1.3 million, respectively, and 1.0 million and 0.8 million for the three and six months ended June 30, 2023, respectively.
Sales Agreement
On December 23, 2022, the Company entered into a Controlled Equity Offering℠ Sales Agreement, which was amended on August 7, 2023 (as amended, the “Sales Agreement”) with Cantor Fitzgerald & Co. (“Cantor”),Wells Fargo Securities, LLC (“Wells Fargo Securities”), and William Blair & Company, L.L.C. (“William Blair”) relating to shares of the Company's common stock. In accordance with the terms of the Sales Agreement, the Company may offer and sell shares of its common stock having an aggregate offering price of up to $200,000,000 from time to time through Cantor, Wells Fargo Securities, or William Blair, each acting as the Company's sales agent. During the period ended June 30, 2024 the Company did not offer or sell any shares of common stock pursuant to the Sales Agreement.
Note 7. Share-Based Compensation Expense
In June 2024 at the Company’s 2024 Annual Meeting of Stockholders (the "2024 Annual Meeting"), the stockholders of the Company approved an amendment to the Company’s 2019 Omnibus Equity Incentive Plan (as amended, the “2019 Plan”) which, among other things, increased the aggregate number of shares authorized for use in making awards to eligible persons under the 2019 Plan by 2,000,000 shares, for a total of up to 10,750,000 shares available for issuance. As of June 30, 2024, following the 2024 Annual Meeting, a total of 2,236,360 shares remain available for future issuance under the 2019 Plan, subject to the terms of the 2019 Plan.
In October 2021, the Company adopted the 2021 Inducement Equity Incentive Plan which covers the award of up to 1,000,000 shares of common stock (the “2021 Plan”) effective as of October 15, 2021. Approval of the Company’s stockholders is not required as a condition to the effectiveness of the 2021 Plan for so long as the plan is in compliance with applicable Nasdaq inducement plan rules. In April 2022, the compensation committee of the Company’s board of directors approved a proposal to reduce the total number of shares available for future issuance under the 2021 Plan to 130,000. As of June 30, 2024, a total of 124,697 shares remain available for future issuance under the 2021 Plan, subject to the terms of the 2021 Plan.
Stock Options
Share-based compensation expense included in the Company’s condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2024 and 2023 was as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Three Months Ended June 30, |
|
|
|
For the Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
|
2023 |
|
|
|
2024 |
|
|
|
2023 |
|
Research and development |
|
$ |
4,378 |
|
|
|
$ |
3,741 |
|
|
|
$ |
9,180 |
|
|
|
$ |
7,249 |
|
General and administrative |
|
|
5,046 |
|
|
|
|
4,642 |
|
|
|
|
10,332 |
|
|
|
|
9,316 |
|
Total |
|
$ |
9,424 |
|
|
|
$ |
8,383 |
|
|
|
$ |
19,512 |
|
|
|
$ |
16,565 |
|
Note 8. Income Taxes
The Company is subject to taxation in the United States and various states. The Company computes its quarterly income tax provision by using a forecasted annual effective tax rate and adjusts for any discrete items arising during the quarter. The primary difference between the effective tax rate and the federal statutory tax rate is due to federal and state income tax expense offset by valuation allowance on the Company's deferred tax assets.
For the three and six months ended June 30, 2024, the Company recorded $(0.2) million and $0.2 million of income tax expense, respectively. For the three and six months ended June 30, 2023, the Company recorded $0.6 million and $0.7 million of income tax expense, respectively. No tax benefit was provided for losses incurred in United States because those losses are offset by a full valuation allowance.
Note 9. Commitments and Contingencies
Cystic Fibrosis Foundation Agreement
On September 25, 2023, the Company amended its Development Program Letter Agreement, dated May 16, 2017 and as amended July 13, 2018 and August 1, 2019, with the Cystic Fibrosis Foundation (“CFF”). Pursuant to the amendment, CFF increased the amount it will award to advance LUNAR-CF to $24.6 million from approximately $15.6 million and the Company agreed to incur at least $15.0 million toward activities under the research plan. Total contra expense of $0.8 million was recognized during the three and six months ended June 30, 2024. For the three and six months ended June 30, 2023, the Company recognized no contra expense
related to the agreement. As of June 30, 2024 and December 31, 2023, $6.9 million and $7.6 million, respectively, remained in accrued liabilities.
Leases
In October 2017, the Company entered into a non-cancellable operating lease agreement for office space adjacent to its previously occupied headquarters. The commencement of the lease began in March 2018 and the lease extends for approximately 84 months from the commencement date with a remaining lease term through March 2025. Monthly rental payments are due under the lease and there are escalating rent payments during the term of the lease. The Company is also responsible for its proportional share of operating expenses of the building and common areas. In conjunction with the new lease, the Company received free rent for four months and received a tenant improvement allowance of $0.1 million. In March 2024, the Company negotiated with the lessor to extend the lease through March 2027.
The Company entered into an irrevocable standby letter of credit with the landlord for a security deposit of $0.1 million upon executing the lease which is included (along with additional funds required to secure the letter of credit) in the balance of non-current restricted cash.
In February 2020, the Company entered into a second non-cancellable operating lease agreement for office space near its current headquarters. The lease extended for 13 months from the commencement date and included a right to extend the lease for one twelve-month period. In February 2021, the Company opted to extend the lease through March 2025 to coincide with the lease term of the Company’s headquarters. In January 2024, the Company vacated this office space with no intention of operating out of the location in the future. Because Arcturus was still engaged in the lease for the property and obligated to make the remaining lease payment through March 31, 2025, the Company recorded an impairment loss in the amount of $1.3 million during the three months ended March 31, 2024, as it would not receive any future economic benefit from the lease. In July 2024, the Company terminated the existing lease agreement, in accordance with its terms, thereby ending their contractual obligation to pay for premise.
In September 2021, the Company entered into a third non-cancellable lease agreement for office, research and development, engineering and laboratory space near its current headquarters, and such lease term commenced during the second quarter of 2022. The initial term of this lease extends ten years and eight months from the date of possession, and the Company has the right to extend the term of the lease for an additional five-year period. When the lease term was determined for the operating lease right-of-use assets and lease liabilities, the extension option for the lease was not included. The lease has a monthly base rent ranging from $0.3 million to $0.4 million which escalates over the lease term. The Company received a free rent period of four months and also pays for various operating costs, including utilities and real property taxes. The Company entered into an irrevocable standby letter of credit with the landlord for a security deposit of $2.0 million upon executing the lease which is included (along with additional funds required to secure the letter of credit) in the balance of non-current restricted cash.
Operating lease right-of-use asset and liability on the condensed consolidated balance sheets represent the present value of remaining lease payments over the remaining lease terms. The Company does not allocate lease payments to non-lease components; therefore, payments for common-area-maintenance and administrative services are not included in the operating lease right-of-use asset and liability. The Company uses its incremental borrowing rate to calculate the present value of the lease payments, as the implicit rate in the lease is not readily determinable.
As of June 30, 2024, the remaining payments of the operating lease liability were as follows:
|
|
|
|
|
(in thousands) |
|
Remaining Lease Payments |
|
2024 |
|
$ |
2,838 |
|
2025 |
|
|
5,019 |
|
2026 |
|
|
5,274 |
|
Thereafter |
|
|
23,703 |
|
Total remaining lease payments |
|
|
36,834 |
|
Less: imputed interest |
|
|
(5,953 |
) |
Total operating lease liabilities |
|
$ |
30,881 |
|
Weighted-average remaining lease term |
|
|
7.5 |
|
Weighted-average discount rate |
|
|
4.8 |
% |
Operating lease costs consist of the fixed lease payments included in operating lease liability and are recorded on a straight-line basis over the lease terms. Operating lease costs were $1.5 million and $2.9 million for the three and six months ended June 30, 2024, respectively, and $1.4 million and $2.8 million for the three and six months ended June 30, 2023, respectively.
Note 10. Related Party Transactions
See “Note 1, Joint Ventures, Equity Method Investments and Variable Interest Entities” for specific details surrounding the Company’s agreement with Axcelead to form the joint venture entity, ARCALIS, Inc.
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
The following is a discussion of the financial condition and results of operations of Arcturus Therapeutics Holdings Inc. for the three and six month periods ended June 30, 2024. Unless otherwise specified herein, references to the “Company,” “Arcturus,” “we,” “our” and “us” mean Arcturus Therapeutics Holdings Inc. and its consolidated subsidiaries. You should read the following discussion and analysis together with the interim condensed consolidated financial statements and related notes included elsewhere herein. For additional information relating to our management’s discussion and analysis of financial conditions and results of operations, please see our Annual Report on Form 10-K for the year ended December 31, 2023 (the “2023 Annual Report”), which was filed with the U.S. Securities and Exchange Commission (the “Commission”) on March 14, 2024. Unless otherwise defined herein, capitalized words and expressions used herein shall have the same meanings ascribed to them in the 2023 Annual Report.
This report includes forward-looking statements which, although based on assumptions that we consider reasonable, are subject to risks and uncertainties which could cause actual events or conditions to differ materially from those currently anticipated and expressed or implied by such forward-looking statements.
You should read this report and the documents that we reference in this report and have filed as exhibits to this report completely and with the understanding that our actual future results may be materially different from what we expect. You should also review the factors and risks we describe in the reports we will file or submit from time to time with the Commission after the date of this report.
Overview
We are a global messenger RNA medicines company focused on the development of infectious disease vaccines and opportunities within liver and respiratory rare diseases. In addition to our messenger RNA (“mRNA”) platform, our proprietary lipid nanoparticle (“LNP”) delivery system, LUNAR®, may enable multiple nucleic acid medicines. Our proprietary self-amplifying mRNA technology (STARR® technology) provides a longer-lasting and broader response at lower dose levels than conventional mRNA. In 2023, our COVID-19 vaccine, ARCT-154 (also referred to as Kostaive®), received marketing authorization approval in Japan and became the world’s first approved self-amplifying RNA (sa-mRNA) vaccine.
We are leveraging our proprietary LUNAR platform and our nucleic acid technologies to develop and advance a pipeline of mRNA-based vaccines and therapeutics for infectious diseases and rare genetic disorders with significant unmet medical needs. We continue to expand this platform by adding new innovative delivery solutions that allow us to expand our discovery efforts. Our proprietary LUNAR technology is intended to address the major hurdles in RNA drug development, namely the effective and safe delivery of RNA therapeutics to disease-relevant target tissues. We believe the versatility of our platform to target multiple tissues, its compatibility with various nucleic acid therapeutics, and our expertise in developing scalable manufacturing processes can allow us to deliver on the next generation of nucleic acid medicines.
Business Updates
Vaccine Collaboration with CSL Seqirus
In November 2022, we entered into a Collaboration and License Agreement (as amended, the “CSL Collaboration Agreement”) with Seqirus, Inc. (“CSL Seqirus”), a part of CSL Limited, and one of the world’s leading influenza vaccine providers, for global exclusive rights to research, develop, manufacture and commercialize self-amplifying mRNA vaccines against COVID-19, influenza and three other respiratory infectious diseases and global non-exclusive rights to pandemic pathogens. The CSL Collaboration Agreement became effective on December 8, 2022. The collaboration combines CSL Seqirus’ established global vaccine commercial and manufacturing infrastructure with Arcturus’ manufacturing expertise and innovative STARR self-amplifying mRNA vaccine and LUNAR delivery platform technologies. Under the framework of our collaboration with CSL Seqirus, we continue the development of the COVID-19 vaccine to establish a differentiated platform and address routine recommendations for periodic vaccine composition updates in a timely manner.
In November 2023, ARCT-154, our self-amplifying RNA (sa-mRNA) vaccine, received marketing authorization approval from the Japanese Ministry of Health, Labour and Welfare for use as a primary immunization and booster in Japan. The approval was based on positive clinical data from several ARCT-154 studies, including the pivotal 19,000 subject efficacy, safety and immunogenicity study performed in Vietnam as well as the pivotal Phase 3 booster study in Japan.
In May 2024, we announced that Nature Communications published results from the 19,000 subject study performed in Vietnam, with results demonstrating that two 5µg doses of ARCT-154 were well-tolerated, immunogenic and provided significant protection against multiple strains of COVID-19. The Japanese Pharmaceuticals and Medical Devices Agency (PMDA) is currently reviewing a partial change application to update our COVID-19 vaccine (Kostaive®) with the JN.1 Variant of Concern. The European Medicines Agency (EMA) is currently reviewing a marketing authorization application for ARCT-154. The review procedure started on August 17, 2023.
We continue to collect data from the various ongoing studies described below.
Key Updates on Our COVID Collaboration Program
Pivotal Phase 3 Non-Inferiority Study of ARCT-154 in Japan
Meiji Holdings Co., Ltd. (“Meiji”) sponsored a randomized, multicenter, Phase 3, observer-blind, active-controlled comparative study to evaluate the safety and immunogenicity of a booster dose of ARCT-154 and to evaluate the non-inferiority of ARCT-154 over COMIRNATY (Monovalent, Original strain). The study targeted a total of 780 adult participants, with half in the ARCT-154 group and half in a comparator group, and completed enrollment with 828 participants in February 2023. As previously announced, the study met all primary and secondary immunogenicity endpoints, including a secondary pre-defined superiority assessment over COMIRNATY (Omicron BA.4/5 strain). Overall, the safety and immunogenicity results of the study support the favorable benefit/risk profile of the ARCT-154 vaccine when administered as a booster dose in adult individuals who previously received other mRNA COVID-19 vaccines.
On February 1, 2024, the journal Lancet Infectious Diseases published the article ‘Persistence of immune responses of a self-amplifying RNA COVID-19 vaccine (ARCT154) versus BNT162b2’ (https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00060-4/fulltext), with 6-month follow-up results from this study. These additional data demonstrate the extended persistence of neutralizing antibodies after ARCT-154 compared with conventional mRNA vaccine in the clinical setting, indicating longer-lasting immunity and implying a longer duration of protection by ARCT-154.
Phase 3 Study of Bivalent Version of COVID-19 Vaccine Candidate in Japan
On September 29, 2023, Meiji initiated an additional Phase 3 clinical study with a bivalent version of our COVID-19 vaccine candidate (ARCT-2301, which combines ancestral strain, ARCT-154 and Omicron BA.4/5) to further support immunogenicity and safety data for our self-amplifying mRNA platform, which may facilitate the timely release of future seasonal updates of our COVID-19 vaccine against evolving variants of concern. On March 19, 2024, Meiji announced that the bivalent vaccine met the primary endpoint (non-inferiority) in the study. The study enrolled 930 healthy adults and individuals with comorbidities, who previously received three to five doses of mRNA COVID-19 vaccines, including the last booster at least three months prior to recruitment. The study compares the investigational vaccine (ARCT-2301) and COMIRNATY (ancestral strain and BA.4/5), to evaluate safety and immunogenicity between observer-blind groups. Both the geometric mean titer (GMT) ratio and seroresponse rate (SRR) difference of neutralizing antibodies against SARS-CoV-2 (Omicron strain BA.4/5) met non-inferiority criteria. In addition, the superiority of
ARCT-2301 to COMIRNATY (BA.4/5) was confirmed for both SARS-CoV-2 (Omicron strain BA.4/5 and Wuhan strain). There were no causally-associated severe or serious adverse events with ARCT-2301.
The results of this study of the bivalent version of our COVID-19 vaccine candidate were not required for approval of ARCT-154 in Japan but will facilitate the timely release of future seasonal updates of the COVID-19 vaccine.
Figure: Geometric mean titers (GMT) of surrogate neutralizing antibodies at Days 1 (baseline) and 29, and geometric mean-fold rises (GMFR) in titers from Day 1 to Day 29; B) GMT Ratio; C) seroresponse rates (SRR) at Day 29; D) SRR Difference – Study ARCT-2301-J01. Note: GMT – Geometric Mean Titer; SRR – seroresponse rate. All values are from the Per Protocol Subset 1 (PPS-1) and are shown with 95% confidence intervals in parentheses. Solid circles (●) represent the Wuhan variant, open circles (○) represent the Omicron BA.4/5 variant, and open squares (☐) represent the Omicron XBB.1.5 variant. Vertical lines represent the threshold for achieving the non-inferiority and superiority comparisons of ARCT-154 to Comirnaty.
Bivalent ARCT-2301, when administered intramuscularly as a booster dose in subjects who had received three to five doses of authorized mRNA COVID-19 vaccines at least three months before the recruitment, demonstrated immunological superiority over the comparator vaccine (COMIRNATY® bivalent: Wuhan strain/Omicron strain BA.4/5), as measured by GMT ratios and seroresponse rates differences for both vaccine strains (prototype Wuhan strain and Omicron BA.4/65 variant). In addition, ARCT-2301 induced a higher immune response against the epidemiologically dominant Omicron XBB.1.5 variant.
Phase 3 Study in Southern Hemisphere of Monovalent XBB1.5 COVID-19 Vaccine Candidate
In March 2024, Arcturus and CSL Seqirus initiated a Phase 3 pivotal study with the ARCT-2303 candidate vaccine containing the XBB1.5 Omicron variant. The purpose of this study is to generate additional immunogenicity and safety data in multiple ethnicities to support regulatory filings globally. In addition, the study will assess the co-administration of the ARCT-2303 vaccine
with the age-appropriate seasonal influenza vaccines. Overall, 1,499 young and older adults were recruited in the study in Australia, Costa Rica, Honduras and the Philippines. The results of this study are expected in the fourth quarter of 2024.
Flu Collaboration Program Updates
LUNAR-qsFLU (Quadrivalent Seasonal Influenza)
Our LUNAR-qsFLU (qs; quadrivalent seasonal) program, now exclusively licensed to CSL Seqirus, has the objective of producing a safe and effective seasonal influenza vaccine candidate with significant advantages over the traditional egg-based inactivated quadrivalent vaccine. Inaccurate predictions of circulating influenza strains as well as mutations due to adaptation in egg-grown vaccines can substantially reduce efficacy on a year-to-year basis. We believe the ability of mRNA platforms to nimbly adapt to new viral strains should help improve efficacy. In addition, we do not expect mRNA vaccines to face the challenge from mutations common to egg-grown vaccines.
LUNAR-qsFLU has been designed to take advantage of our expertise in both LUNAR lipid delivery systems and our STARR self-amplifying mRNA technology. This platform has been shown to deliver effective protection against COVID-19 and has been optimized to elicit robust immunogenicity with acceptable reactogenicity at a lower dose than conventional mRNA vaccines with the objective of creating a highly effective influenza vaccine for use in general and high-risk populations. Working with CSL Seqirus, we generated a comprehensive non-clinical data package to support the initiation of the Phase 1 clinical trial with a novel influenza mRNA vaccine candidate. A Phase 1 dose-finding safety and immunogenicity study was initiated in January 2024 in Australia. As of August 1, 2024, 100 healthy young adults and 35 older adults were recruited in the study and received one of four dose levels of the study vaccine or a licensed influenza vaccine.
Pandemic Influenza Program
Our LUNAR-pandFLU program continues to progress under the award from the Biomedical Advanced Research and Development Authority (“BARDA”) that we obtained in 2022. The program includes all non-clinical, manufacturing, and regulatory support to advance a vaccine to protect against disease caused by H5N1 highly-pathogenic avian influenza. A pre-IND meeting was granted and Written Response Only (“WRO”) was received for integration into future development plans. Nonclinical safety studies have been completed that will enable the Phase 1 clinical trial. Enrollment for a Phase 1 clinical trial designed to evaluate the safety and immunogenicity of ARCT-2304 (LUNAR-pandFLU candidate vaccine) is expected to begin before the end of 2024.
Key Updates on Arcturus-Owned mRNA Therapeutic Development Candidates
The following chart represents our current pipeline of Arcturus-owned mRNA therapeutic candidates:
oA Phase 1b study in stable OTC-deficient adults completed dosing in the United States in August 2023. The trial was designed to assess safety, tolerability and pharmacokinetics of a single dose of ARCT-810, as well as exploratory biomarkers of drug activity. The Phase 1b study was a single ascending dose, placebo-controlled study that enrolled 16 adults with mild OTCD. ARCT-810 was generally safe and well tolerated at doses ranging from 0.1-0.5mg/kg and no severe adverse events were observed. Sporadic infusion-related reactions (IRRs) could be managed with symptomatic treatment and appear to be less frequent with slower infusion rates. In plasma, ARCT-810 mRNA could be detected up to 4 weeks, while ionizable lipid was no longer measurable after 48 hours, indicating rapid degradation of the lipid nanoparticle that was utilized to deliver ARCT-810 mRNA.
oA Phase 2 double-blind multiple-dose study of ARCT-810 in OTC-deficient adolescents and adults in the European Union and United Kingdom initiated dosing in December 2022. In July 2024, the Phase 2 study completed enrollment of eight subjects, including adolescents and adults, at the 0.3 mg/kg dose level. The participants in this
group are randomized 3:1 to receive 6 doses of ARCT-810 or placebo administered every 14 days. Treatment and follow-up are ongoing.
oWe are expanding the Phase 2 clinical program of ARCT-810 by enrolling patients in the U.S. with more serious disease. Patient screening has been initiated in the study.
•LUNAR-CF/ARCT-032 – Our program for cystic fibrosis is being supported in part by the Cystic Fibrosis Foundation (“CFF”). In 2023 we initiated and successfully achieved the recruitment target in a Phase 1 single ascending dose study of ARCT-032 (LUNAR-CF), our mRNA therapeutic candidate for cystic fibrosis (CF), in 32 healthy participants (eight subjects in each of four dose cohorts). In August 2023 we received regulatory approval of a protocol amendment to transition to a Phase 1b clinical study of ARCT-032 in up to eight adults with CF, with each participant receiving two administrations of ARCT-032.
oOn June 7, 2024, we presented Phase 1 interim data of ARCT-032 at the 47th Annual European Cystic Fibrosis Conference. ARCT-032 was generally safe and well tolerated with no serious or severe adverse events in healthy volunteers and in the first four dosed participants with CF in Phase 1b, of which one had 2 Class I mutations and the other three had F508del mutations and were being treated with Trikafta®.
oWe submitted an IND application at the end of July 2024 for an ARCT-032 Phase 2 multiple ascending dose study designed to identify a safe and effective dose in Class I (null) and other CF participants who do not benefit from CFTR modulators. This study is supported by safety and tolerability data collected in healthy volunteers (N = 32) and the ongoing two-administration Phase 1b study. No serious adverse events (SAEs) have been observed in any clinical trial participants to date. No febrile reactions have been observed within the target dose range of the planned Phase 2 study. The Phase 1b study has completed dosing and follow-up visits. Of the seven total CF participants in Phase 1b, six are receiving CFTR modulator treatment while one subject has Class I mutations and therefore does not benefit from modulator therapy. The Class I CF subject had low lung function at baseline (ppFEV1 below 50%) and showed an improvement of 4% in ppFEV1 on Day 8, after receiving two well-tolerated administrations, with no febrile reactions..
oIn February 2024, the European Commission (EC), based on a positive opinion issued by the European Medicines Agency (EMA), granted Orphan Medicinal Product Designation for ARCT-032 to treat CF. ARCT-032 was granted Rare Pediatric Disease Designation in October 2023, and Orphan Drug Designation in November 2023 by the FDA.
Updates on Collaboration Agreements
CSL Collaboration Agreement.
In March 2024, we entered into Amendment Number Two to Collaboration and License Agreement between CSL and the Company to reflect updates to the development program and other adjustments consistent with our prior disclosures regarding the Collaboration and License Agreement (“Amendment Number Two”). Amendment Number Two, among other things, adjusts (i) the development plans for certain product candidates, (ii) various development milestones related to such product candidates, (iii) provisions of the CSL Collaboration Agreement related to specific royalty payments, (iii) provisions of the CSL Collaboration Agreement related to distributors, and (iv) proprietary payment calculations related to the foregoing.
Updates on Research and Platform Activities
We continue to conduct exploratory platform development activities, including the evaluation of genome editing, and new targeting approaches, where our LUNAR® and STARR® platforms could potentially be useful for identification and development of additional products for our portfolio.
Discovery Programs – Vaccine Programs (Lyme Disease and Gonorrhea)
Based on the clinical and regulatory validation of LUNAR and STARR technologies provided by the approval of ARCT-154, our next-generation vaccine for COVID-19, we have initiated new vaccine discovery programs for Lyme disease and gonorrhea. The new discovery programs rely on the evidence of superior immunogenicity, durability, and breadth of immune response compared to conventional mRNA vaccines, as observed in the COVID-19 program.
Lyme disease is a bacterial infection and is the most common vector-borne disease in the United States. Infection can spread to joints, the heart and the nervous system. Gonorrhea is a sexually transmitted disease (STD) that can infect the mucous membranes of the reproductive tract. It is the second most commonly reported bacterial sexually transmitted infection in the United States. We selected these diseases based on high unmet medical needs, good understanding of the path forward in vaccine target selection, and demonstration of proof of concept, as well as platform advantages that may be translated in a favorable vaccine product.
Updates on Supply and Manufacturing
We have built a global manufacturing footprint with our partners, including Aldevron, Catalent, Recipharm, Polymun and ARCALIS. With such collaborations we have established an Integrated Global Supply Chain Network with our primary and secondary sourcing contract development & manufacturing organizations (CDMOs) based in the United States, EU and Asia for producing critical raw materials, drug substance, and packaged finished product. As the market for COVID vaccines shifts from multi-dose vial formats to lower and single-dose vial formats, we continue, with our collaborator CSL Seqirus, to evaluate and advance manufacturing process and capabilities and technology transfers, and prepare for stockpiling and commercialization of COVID vaccines.
Results of Operations
The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our condensed consolidated financial statements and related notes appearing elsewhere in this Report and our audited financial statements and related notes for the year ended December 31, 2023. Our historical results of operations and the year-to-year comparisons of our results of operations that follow are not necessarily indicative of future results.
Revenue
We enter into arrangements with pharmaceutical and biotechnology partners and government agencies that may contain upfront payments, license fees for research and development arrangements, research and development funding, milestone payments, option exercise and exclusivity fees, royalties on future sales, consulting fees and payments for technology transfers. The following table summarizes our total revenues for the periods indicated:
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|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended June 30, |
|
|
2023 to 2024 |
(in thousands) |
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
Revenue |
|
$ |
49,859 |
|
|
$ |
10,519 |
|
|
$ |
39,340 |
|
|
* |
* Greater than 100%
Revenue increased by $39.3 million during the three months ended June 30, 2024 as compared to the three months ended June 30, 2023. The increase was primarily attributable to the receipt of a milestone payment from CSL pursuant to the CSL agreement as $45.9 million total revenue was recognized during the second quarter of 2024, compared to $7.6 million total revenue related to CSL during the second quarter of 2023, resulting in an increase of $38.3 million primarily due to the timing and value of milestone achievements and the recognition of revenue from a supply agreement during the current quarter. Additionally, there was an increase in revenue of $2.9 million related to the BARDA Contract during the second quarter of 2024 as compared to the second quarter of 2023. The total increase in revenue was offset by a $1.9 million decrease in revenue recognized from other agreements during the second quarter of 2024 as compared to the second quarter of 2023 due to lower activity or completion of collaboration agreements.
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|
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|
|
|
Six Months Ended June 30, |
|
|
2023 to 2024 |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
Revenue |
|
$ |
87,871 |
|
|
$ |
90,804 |
|
|
$ |
(2,933 |
) |
|
|
-3.2 |
% |
Revenue decreased by $2.9 million during the six months ended June 30, 2024 as compared to the six months ended June 30, 2023. We received revenue under the CSL agreement of $78.3 million during the six months ended June 30, 2024, compared to $85.8 million total revenue related to CSL during the six months ended June 30, 2023, resulting in a decrease of $7.5 million primarily due to the timing and value of milestone achievements and the achievement of a conditional payment during the first half of 2023, offset by the recognition of revenue from a supply agreement during the current year. Additionally, there was a decrease of $3.2 million in revenue recognized under other agreements during the six months ended June 30, 2024 as compared to the six months ended June 30, 2023 due to lower activity or completion of collaboration agreements. The total decrease in revenue was offset by a $7.8 million increase in revenue recognized from the BARDA Contract during the six months ended June 30, 2024 as compared to the six months ended June 30, 2023.
Our operating expenses consist of research and development and general and administrative expenses.
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|
|
Three Months Ended June 30, |
|
|
2023 to 2024 |
|
|
Six Months Ended June 30, |
|
|
2023 to 2024 |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
Operating expenses: |
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and development, net |
|
$ |
58,669 |
|
|
$ |
52,668 |
|
|
$ |
6,001 |
|
|
|
11.4 |
% |
|
$ |
112,242 |
|
|
$ |
104,436 |
|
|
$ |
7,806 |
|
|
|
7.5 |
% |
General and administrative |
|
|
12,316 |
|
|
|
13,225 |
|
|
|
(909 |
) |
|
|
-6.9 |
% |
|
|
27,167 |
|
|
|
26,987 |
|
|
|
180 |
|
|
|
0.7 |
% |
Total |
|
$ |
70,985 |
|
|
$ |
65,893 |
|
|
$ |
5,092 |
|
|
|
7.7 |
% |
|
$ |
139,409 |
|
|
$ |
131,423 |
|
|
$ |
7,986 |
|
|
|
6.1 |
% |
Research and Development Expenses, net
The following table presents our total research and development expenses by category:
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|
|
Three Months Ended June 30, |
|
|
2023 to 2024 |
|
|
Six Months Ended June 30, |
|
|
2023 to 2024 |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
External pipeline development expenses: |
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|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
LUNAR-COVID, net |
|
$ |
22,327 |
|
|
$ |
19,688 |
|
|
$ |
2,639 |
|
|
|
13.4 |
% |
|
$ |
43,057 |
|
|
$ |
42,516 |
|
|
$ |
541 |
|
|
|
1.3 |
% |
LUNAR-OTC, net |
|
|
4,926 |
|
|
|
2,200 |
|
|
|
2,726 |
|
|
* |
|
|
|
6,310 |
|
|
|
5,519 |
|
|
|
791 |
|
|
|
14.3 |
% |
BARDA |
|
|
2,367 |
|
|
|
491 |
|
|
|
1,876 |
|
|
* |
|
|
|
5,602 |
|
|
|
646 |
|
|
|
4,956 |
|
|
* |
|
Early-stage programs |
|
|
11,579 |
|
|
|
7,072 |
|
|
|
4,507 |
|
|
|
63.7 |
% |
|
|
18,942 |
|
|
|
11,786 |
|
|
|
7,156 |
|
|
|
60.7 |
% |
Discovery technologies |
|
|
1,192 |
|
|
|
6,853 |
|
|
|
(5,661 |
) |
|
|
-82.6 |
% |
|
|
2,382 |
|
|
|
11,604 |
|
|
|
(9,222 |
) |
|
|
-79.5 |
% |
External platform development expenses: |
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
Personnel related expenses |
|
|
13,998 |
|
|
|
13,458 |
|
|
|
540 |
|
|
|
4.0 |
% |
|
|
29,515 |
|
|
|
26,728 |
|
|
|
2,787 |
|
|
|
10.4 |
% |
Facilities and equipment expenses |
|
|
2,280 |
|
|
|
2,906 |
|
|
|
(626 |
) |
|
|
-21.5 |
% |
|
|
6,434 |
|
|
|
5,637 |
|
|
|
797 |
|
|
|
14.1 |
% |
Total research and development expenses, net |
|
$ |
58,669 |
|
|
$ |
52,668 |
|
|
$ |
6,001 |
|
|
|
11.4 |
% |
|
$ |
112,242 |
|
|
$ |
104,436 |
|
|
$ |
7,806 |
|
|
|
7.5 |
% |
* Greater than 100%
Our research and development expenses consist primarily of external manufacturing costs, in-vivo research studies and clinical trials performed by contract research organizations, clinical and regulatory consultants, personnel related expenses, facility related expenses and laboratory supplies related to conducting research and development activities. Research and development expenses were $58.7 million for the three months ended June 30, 2024, compared with $52.7 million for the three months ended June 30, 2023, primarily reflecting increased clinical related expenses of $6.3 million, increased manufacturing expenses of $0.8 million and increased personnel expenses of $0.5 million. The increases were offset by a $1.0 million increase in contra research and development expenses related to the agreement with the CFF and a $0.6 million decrease in facilities and equipment expenses. Research and development expenses were $112.2 million for the six months ended June 30, 2024, compared with $104.4 million in the six months ended June 30, 2023, primarily reflecting increased clinical related expenses of $6.3 million, increased personnel related expenses of $2.8 million, increased facilities and equipment expenses of $0.8 million and increased manufacturing expenses of $0.3 million. The increases were offset by $1.4 million in consulting expenses and a $1.0 million increase in contra research and development expenses related to the agreement with the CFF. We expect that our research and development efforts and associated costs will continue to be substantial over the next several years as our pipeline progresses.
Early-stage programs represent programs that are in the pre-clinical or Phase 1 clinical stage and may be partnered or unpartnered, including the LUNAR-CF and LUNAR-FLU programs. Discovery technologies represent our efforts to expand our product pipeline and are primarily related to pre-partnered studies and new capabilities assessment. For some of our programs, the activities are part of our collaborative and other relationships, and the expenses may be partially offset with funds that have been awarded to the Company. The expenses for early-stage programs and discovery technologies primarily consist of external manufacturing costs, lab supplies, equipment, and consulting and professional fees. Both early-stage programs and discovery technologies expenses are expected to steadily increase over the coming years.
Personnel related expenses primarily consist of employee salaries and benefits, share-based compensation and consultants. Although such expenses increased during 2024 as compared to 2023, we expect that they will not increase over the next twelve months.
Facilities and equipment expenses primarily consist of rent expense, common area maintenance charges, shipping costs, various costs of our offices and laboratories and depreciation expenses. Facilities and equipment expenses are not expected to increase during the next twelve months.
General and Administrative Expenses
General and administrative expenses primarily consist of salaries and related benefits for our executive, administrative, legal and accounting functions and professional service fees for legal and accounting services as well as other general and administrative expenses.
General and administrative expenses were $12.3 million for the three months ended June 30, 2024 compared with $13.2 million for the three months ended June 30, 2023. The decrease in expenses resulted primarily from decreased personnel expenses of $0.6 million, decreased facilities expenses of $0.3 million and decreased travel expenses of $0.2 million. The overall decrease was offset by an increase of $0.2 million in legal expenses. General and administrative expenses were $27.2 million for the six months ended June 30, 2024 compared with $27.0 million in the six months ended June 30, 2023. The increase in expenses resulted primarily from a $0.5 million increase in accounting and legal fees, a $0.5 million increase in supplies and a $0.1 million increase in software expense.
The increase was offset by a decrease of $0.6 million in personnel related expenses and a decrease of $0.3 million in insurance costs. The Company does not expect that general and administrative expenses will increase on a yearly basis from the current quarter June 30, 2024 expense trend.
Finance income (expense), net
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|
|
Three Months Ended June 30, |
|
|
2023 to 2024 |
|
|
Six Months Ended June 30, |
|
|
2023 to 2024 |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
Interest income |
|
$ |
4,148 |
|
|
$ |
3,252 |
|
|
$ |
896 |
|
|
|
27.6 |
% |
|
$ |
8,164 |
|
|
$ |
6,472 |
|
|
$ |
1,692 |
|
|
|
26.1 |
% |
Interest expense |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
0.0 |
% |
|
|
— |
|
|
|
(743 |
) |
|
|
743 |
|
|
|
100.0 |
% |
Total |
|
$ |
4,148 |
|
|
$ |
3,252 |
|
|
$ |
896 |
|
|
|
27.6 |
% |
|
$ |
8,164 |
|
|
$ |
5,729 |
|
|
$ |
2,435 |
|
|
|
42.5 |
% |
* Greater than 100%
Interest income is generated on cash and cash equivalents. The increase in interest income for the three months ended June 30, 2024 as compared to the three months ended June 30, 2023 was primarily the result of increased interest earned on investment accounts. Interest expense during the six months ended June 30, 2023 was incurred in conjunction with the Western Alliance Agreement and the Singapore Loan, both of which have since been terminated.
Other income and expense
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|
|
|
|
Three Months Ended June 30, |
|
|
2023 to 2024 |
|
Six Months Ended June 30, |
|
|
2023 to 2024 |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
2024 |
|
|
2023 |
|
|
$ change |
|
|
% change |
|
(Loss) gain from foreign currency |
|
$ |
(388 |
) |
|
$ |
149 |
|
|
$ |
(537 |
) |
|
* |
|
$ |
(441 |
) |
|
$ |
(179 |
) |
|
$ |
(262 |
) |
|
* |
|
Gain on debt extinguishment |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
* |
|
|
— |
|
|
|
33,953 |
|
|
|
(33,953 |
) |
|
* |
|
Total |
|
$ |
(388 |
) |
|
$ |
149 |
|
|
$ |
(537 |
) |
|
* |
|
$ |
(441 |
) |
|
$ |
33,774 |
|
|
$ |
(34,215 |
) |
|
|
-101.3 |
% |
* Greater than 100%
Other income and expense items primarily relate to gains and losses from foreign currency transactions. Additionally, we recorded a gain on debt extinguishment related to the Singapore Loan of $34.0 million during the first quarter of 2023 as a result of the Singapore Loan being forgiven.
Off-balance sheet arrangements
Through June 30, 2024, we have not entered into and did not have any relationships with unconsolidated entities or financial collaborations, such as entities often referred to as structured finance or special purpose entities, established for the purpose of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes.
Liquidity and Capital Resources
From the Company’s inception through the quarter ended June 30, 2024, the Company has funded its operations principally with the proceeds from the sale of capital stock, long-term debt and revenues earned through collaboration agreements and government contracts. Through the second quarter of 2024, we have achieved a total of approximately $437.1 million in upfront payments and milestones from CSL Seqirus, including a milestone of $17.0 million achieved in the current quarter with payment anticipated in the third quarter of 2024. At June 30, 2024, we had $317.2 million in cash and cash equivalents and restricted cash.
CSL Seqirus, Inc. Collaboration and License Agreement
We entered into the CSL Collaboration Agreement with CSL Seqirus, a part of CSL Limited, one of the world’s leading influenza vaccine providers, for the global exclusive rights to research, develop, manufacture and commercialize mRNA vaccines.
CSL Seqirus received exclusive global rights to our technology for vaccines against SARS-CoV-2 (COVID-19), influenza and three other respiratory infectious diseases and non-exclusive rights to pandemic pathogens. We received an up-front payment of $200.0 million during the fourth quarter of 2022. We will be eligible to receive development milestones totaling more than $1.3 billion if all products are registered in the licensed fields. We will also be entitled to receive up to $3.0 billion in commercial milestones based on “net sales” of vaccines in the various fields.
In addition, we are entitled to receive a 40% share of net profits from COVID-19 vaccine sales and up to low double-digit royalties of annual net sales for vaccines against influenza and the other three specified infectious disease pathogens, as well as royalties on revenues from vaccines that may be developed for pandemic preparedness.
The CSL Collaboration Agreement sets forth how CSL Seqirus and we shall collaborate to research and develop vaccine candidates. In the COVID-19 field, we will lead activities for certain regulatory filings for ARCT-154 in the US and Europe and for research and development activities of a next-generation COVID vaccine candidate. CSL Seqirus will lead and be responsible for all other research and development in COVID-19, influenza and the other fields.
Wells Fargo Credit Agreement
On April 21, 2023, the Company’s wholly-owned subsidiary, Arcturus Therapeutics, Inc. entered into a credit agreement with Wells Fargo Bank, National Association (“Wells Fargo”) whereby Wells Fargo agreed to make a $50.0 million revolving credit line available to the Company (the “Wells Fargo Loan”) and each Wells Fargo Loan evidenced by a revolving line of credit note (the “Note”).
Borrowings under the agreement will bear interest at a rate of 1.00% above either the Daily Simple SOFR or Term SOFR (as such terms are defined in the Wells Fargo Note), with “SOFR” being the rate per annum equal to the secured overnight financing rate as administered by the Federal Reserve Bank of New York. If an Event of Default (as defined in the credit agreement) occurs, then all Wells Fargo Loans shall bear interest at a rate equal to 2.00% above the interest rate applicable immediately prior to the occurrence of the Event of Default. As of June 30, 2024, no borrowings were made against the Wells Fargo Note.
The term of the agreement was originally two years, with an option for one-year renewals subject to Wells Fargo approval and the Company furnishing to Wells Fargo a non-refundable commitment fee equal to 0.25% of the Wells Fargo Loan amount for each such renewal. In June 2024, Arcturus Therapeutics and Wells Fargo entered into an amendment to the Note, whereby the term of the Note was extended by one year to April 2026. There is no penalty for terminating the agreement. There is no penalty for terminating the facility prior to the maturity date of the Wells Fargo Note. As collateral, the Company has agreed to pledge $55.0 million in cash to be held at the Company’s securities accounts with Wells Fargo Securities, LLC, an affiliate of Wells Fargo, pursuant to a security agreement.
Grant from the Biomedical Advanced Research and Development Authority
On August 31, 2022, we entered into a cost reimbursement contract (the “BARDA Contract”) with the Biomedical Advanced Research and Development Authority (“BARDA”), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS) to support the development of a low-dose pandemic influenza candidate based on our proprietary self-amplifying messenger RNA-based vaccine platform. The BARDA Contract is to support our non-clinical and pre-clinical development, early-stage clinical development through Phase 1, and associated drug product manufacturing, regulatory and quality-assurance activities over a period of three years. It provides for reimbursement by BARDA of our permitted costs up to $63.2 million.
Vinbiocare Agreement
During 2021, we entered into a technology license and technical support agreement and the framework drug substance supply agreement with Vinbiocare, a member of Vingroup Joint Stock Company (collectively, the “Vinbiocare License & Supply Agreements”), whereby we would provide technical expertise and support services to Vinbiocare to assist in the build out of an mRNA drug product manufacturing facility in Vietnam. We received an upfront payment in aggregate of $40.0 million as part of the Vinbiocare License and Supply Agreements. In October 2022, in association with the termination of the Vinbiocare License and Supply Agreements, we signed the Vinbiocare Support Agreement with Vinbiocare which continues Vinbiocare’s clinical obligations and reserved a portion of the original $40.0 million upfront payment received from the License and Supply Agreements to be paid over the future periods.
The Vinbiocare Support Agreement requires us to pay to Vinbiocare certain limited payments, including upon the occurrence of specified events through the first quarter of 2025. Vinbiocare is also eligible to receive a single digit percentage of amounts received by Arcturus on net sales, if any, of ARCT-154 (or next-generation COVID vaccine) up to a capped amount.
General Financial Resources
A portion of our current cash balance is expected to be utilized during fiscal year 2024 to fund (i) advances to our LUNAR-CF program in clinical trials, (ii) the continued Phase 2 trial of ARCT-810, our LUNAR-OTC candidate, (iii) expenses incurred prior to customer payments under the CSL Collaboration Agreement and BARDA Contract and (iv) continued exploratory activities related to our platform and other general administrative activities.
Our future capital requirements are difficult to forecast and will depend on many factors that are out of our control. If we are unable to maintain sufficient financial resources, our business, financial condition and results of operations will be materially and adversely affected. There can be no assurance that we will be able to obtain additional needed financing on acceptable terms or at all. Additionally, equity or debt financings may have a dilutive effect on the holdings of our existing shareholders.
We expect to continue to incur additional losses in the long term, and we will need to execute on milestones within the CSL Collaboration Agreement, raise additional debt or equity financing or enter into additional partnerships to fund development. Our ability to transition to profitability is dependent on executing on milestones within the CSL Collaboration Agreement, successful
clinical trials for OTC and CF and identifying and developing successful mRNA drug and vaccine candidates. If we are not able to achieve planned milestones or incur costs in excess of our forecasts, we will need to reduce discretionary spending, discontinue the development of some or all of our programs, which will delay part of our development programs, all of which will have a material adverse effect on our ability to achieve our intended business objectives.
Funding Requirements
We anticipate that we will continue to generate losses for the foreseeable future, and we expect the losses to increase as we continue the development of, and seek regulatory approvals for, our product candidates, and begin commercialization of our products. As a result, we will require additional capital to fund our operations in order to support our long-term plans. We believe that our current cash position will be sufficient to meet our anticipated cash requirements through at least the next twelve months, assuming, among other things, no significant unforeseen expenses and continued funding from partners at anticipated levels. We intend to seek additional capital through equity and/or debt financings, collaborative or other funding arrangements with partners or through other sources of financing. Should we seek additional financing from outside sources, we may not be able to raise such financing on terms acceptable to us or at all. If we are unable to raise additional capital when required or on acceptable terms, we may be required to scale back or discontinue the advancement of product candidates, reduce headcount, liquidate our assets, file for bankruptcy, reorganize, merge with another entity, or cease operations.
Our future funding requirements are difficult to forecast and will depend on many factors, including the following:
•the development of our LUNAR-COV19 and LUNAR-FLU vaccine candidates;
•the achievement of milestones under our strategic alliance agreements;
•maintaining and/or expanding our manufacturing network and capabilities;
•the terms and timing of any other strategic alliance, licensing and other arrangements that we may establish, including those with CSL Seqirus and CSL Seqirus’ arrangement with Meiji, and any related payments thereunder;
•the initiation, progress, timing and successful completion of preclinical studies and clinical trials for our product candidates, including OTC and CF;
•the number and characteristics of product candidates that we pursue;
•the outcome, timing and cost of regulatory approvals;
•delays that may be caused by changing regulatory requirements;
•the cost and timing of hiring new employees to support our continued growth;
•the costs involved in filing and prosecuting patent applications and enforcing and defending patent claims;
•the costs and timing of procuring clinical and commercial supplies of our product candidates;
•the costs and timing of establishing sales, marketing and distribution capabilities;
•the costs associated with legal proceedings;
•the costs associated with potential litigation related to collaboration agreements; and
•the extent to which we acquire or invest in businesses, products or technologies.
Critical Accounting Policies and Estimates
We prepare our condensed consolidated financial statements in conformity with GAAP. As such, we make certain estimates, judgments and assumptions that we believe are reasonable, based upon information available to us. These judgments involve making estimates about the effect of matters that are inherently uncertain and may significantly impact our reported results of operations and financial condition. We describe our significant accounting policies more fully in Note 2 to our consolidated financial statements for the year ended December 31, 2023.
There have been no material changes to our critical accounting policies and estimates from the information provided in Item 7, Management’s Discussion and Analysis of Financial Condition and Results of Operations, included in the 2023 Annual Report.
Item 3. Quantitative and Qualitative Disclosures About Market Risk.
Our primary exposure to market risk is interest income sensitivity, which is affected by changes in the general level of interest rates in the United States. Due to the nature of our cash and cash equivalents, we believe that we are not subject to any material market risk exposure. We do not have any foreign currency or other derivative financial instruments.
Item 4. Controls and Procedures.
Evaluation of Disclosure Controls and Procedures
As required by Rule 13a-15(b) and Rule 15d-15(b) of the Exchange Act, our management, including our principal executive officer, our principal financial officer and our principal accounting officer, conducted an evaluation as of the end of the period covered by this Quarterly Report on Form 10-Q of the effectiveness of the design and operation of our disclosure controls and procedures. Based on that evaluation, management has concluded that as of June 30, 2024, our disclosure controls and procedures were not effective due to the material weaknesses in internal control over financial reporting described below.
The Company’s disclosure controls and procedures have been designed to ensure that: (i) information required to be disclosed by us in reports that we file or submit to the SEC under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in applicable rules and forms and (ii) material information required to be disclosed in our reports filed under the Exchange Act is accumulated and communicated to management, including the CEO and the CFO, as appropriate, to allow for accurate and timely decisions regarding required disclosure.
Management does not expect that our disclosure controls and procedures will prevent all error and all fraud. The effectiveness of our or any system of disclosure controls and procedures, however well designed and operated, can provide only reasonable assurance that the objectives of the system will be met and is subject to certain limitations, including the exercise of judgment in designing, implementing, and evaluating controls and procedures and the assumptions used in identifying the likelihood of future events.
Material Weaknesses in Internal Control over Financing Reporting Existing as of June 30, 2024
A material weakness is a deficiency, or a combination of deficiencies, in internal control over financial reporting, such that there is a reasonable possibility that a material misstatement of our annual or interim consolidated financial statements will not be prevented or detected on a timely basis.
Management concluded that the material weaknesses disclosed in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2024 continued to exist as of June 30, 2024. Specifically, management concluded that the following material weaknesses exist as of June 30, 2024:
•A material weakness related to information technology general controls (“ITGCs”) that support our financial reporting processes; Management determined that we did not maintain effective controls over (i) user access to ensure appropriate segregation of duties and adequately restrict user and privileged access to financial applications, programs and data to the appropriate personnel; (ii) program change management for financial applications to ensure that information technology (“IT”) program and data changes affecting financial IT applications and underlying accounting records are identified, tested, authorized and implemented appropriately; and (iii) IT operations controls to ensure that critical interface jobs are monitored. As a result, our related IT dependent manual and application controls that rely upon the affected ITGCs, or information coming from IT systems with affected ITGCs, were also deemed ineffective.
•A material weakness related to revenue recognition. Management determined that certain control activities within the area of revenue did not operate effectively, specifically controls over the review of costs incurred in satisfaction of our performance obligations under collaboration arrangements.
Notwithstanding the identified material weaknesses, management does not believe that the deficiencies had an adverse effect on our reported operating results or financial condition, and management has determined that the financial statements and other information included in this report and other periodic filings present fairly in all material respects our financial condition and results of operations at and for the periods presented.
Plan for Remediation of Material Weaknesses
Our remediation efforts are ongoing, and we will continue our initiatives to implement measures designed to ensure that control deficiencies contributing to the material weaknesses are remediated, such that these controls are designed, implemented, and operating effectively. We are committed to making the necessary changes and improvements to our system of controls to address the material weaknesses in internal control over financial reporting described above.
Our renewed emphasis of designing and implementing improved processes and controls involves but is not limited to the following:
•Expand available resources with experience designing and implementing control activities, including ITGCs and automated controls, both by hiring internally and the use of third-party consultations and specialists.
•Adjust access profiles in IT systems and relevant software, and adjust access review controls accordingly.
•Refine the control to identify access profiles in IT systems and software that result in risks of segregation of duties.
•Perform ongoing training with control performers to improve documentation that supports effective control activities, including evidence over the completeness and accuracy of information produced by the Company.
•Add additional technical accounting resource to review our revenue accounting along with financial disclosures for collaboration arrangements on a quarterly basis.
We are in the process of implementing the remediation activities as of the date of this report and believe that upon completion, we will have strengthened our ITGCs, and controls related to accounting for collaboration arrangements to address and successfully remediate the identified material weaknesses. However, control weaknesses are not considered remediated until new internal controls have been operational for a period of time, are tested, and management concludes that these controls are operating effectively. We expect to complete the remediation activities in the fiscal year 2024. We will continue to monitor the effectiveness of these remediation measures, and we will make any changes to the design of this plan and take such other actions that we deem appropriate given the circumstances.
Changes in Internal Control over Financial Reporting
As required by Rule 13a-15(d) and Rule 15d-15(d) of the Exchange Act, our management, including our principal executive officer and our principal financial and accounting officer, conducted an evaluation of the internal control over financial reporting to determine whether any other changes occurred during the period covered by this Quarterly Report on Form 10-Q that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting. Based on that evaluation, our principal executive officer and our principal financial and accounting officer concluded that there were no changes in our internal controls over financial reporting during the periods covered by this Quarterly Report on Form 10-Q that materially affected, or were reasonably likely to materially affect, our internal control over financial reporting.
PART II—OTHER INFORMATION
Item 1. Legal Proceedings.
From time to time, we may be involved in various legal proceedings and subject to claims that arise in the ordinary course of business, including those related to governmental inquiries, intellectual property and commercial relationships. The subject matter of any such legal proceedings or claims are or will be highly complex and subject to substantial uncertainties. The outcome of any such proceedings or claims, regardless of the merits, are and will be inherently uncertain; therefore, assessing the likelihood of loss and any estimated damages is difficult and subject to considerable judgment.
Item 1A. Risk Factors.
Our business is subject to various risks, including those described in Item 1A of our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, which we strongly encourage you to review. There have been no material changes from the risk factors described in our Annual Report on Form 10-K for the year ended December 31, 2023 filed with the Commission on March 14, 2024.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
None.
Item 3. Defaults Upon Senior Securities.
None.
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
Rule 10b5-1 Trading Arrangements
During the three months ended June 30, 2024, none of our directors or officers adopted or terminated a "Rule 10b5-1 trading arrangement" (as defined in Item 408 of Regulation S-K of the Exchange Act) intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act, other than as follows:
•Lance Kurata, our Chief Legal Officer, adopted a Rule 10b5-1 trading arrangement as of June 12, 2024. Mr. Kurata's trading arrangement provides for the exercise of up to an aggregate of 35,000 options to purchase shares of common stock and subsequent sale of such underlying shares of common stock, until June 12, 2025.
Item 6. Exhibits.
Exhibit Index
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Exhibit Number |
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Description |
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1.1 |
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Controlled Equity Offering℠ Sales Agreement, dated as of December 23, 2022 by and between Cantor Fitzgerald & Co, Wells Fargo Securities, LLC and Arcturus Therapeutics Holdings Inc. Incorporated by reference to Exhibit 1.2 to Registration Statement on Form S-3 filed on December 23, 2022 (File No. 333269003). |
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1.2 |
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Amendment No. 1 to Controlled Equity Offering℠ Sales Agreement by and between Cantor Fitzgerald & Co, Wells Fargo Securities, LLC, William Blair & Company, L.L.C., and Arcturus Therapeutics Holdings Inc. Incorporated by reference to Exhibit 1.1 to Form 8-K filed on August 7, 2023. |
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3.1 |
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Certificate of Incorporation. Incorporated by reference to Annex B to the proxy statement/prospectus which forms part of the Registration Statement on Form S-4 filed on March 18, 2019 (File No. 333-230353). |
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3.2 |
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Certificate of Amendment, dated November 25, 2020. Incorporated by reference to Exhibit 3.1 to Form 8-K filed on November 25, 2020 (File No. 001-38942). |
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3.3 |
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Bylaws of Arcturus Therapeutics Holdings Inc. Incorporated by reference to Exhibit 3.2 to the Company’s Registration Statement on Form S-3, filed with the SEC on May 8, 2020 (File No. 333-238139). |
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4.1 |
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Description of Registrant’s Securities. Incorporated by reference to Exhibit 4.1 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 filed on February 28, 2022 (File No. 001-38942). |
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10.1 |
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Form of Indemnification Agreement. Incorporated by reference to Exhibit 10.1 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2019 filed on March 16, 2020 (File No. 001-38942). |
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10.2 |
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Amended and Restated 2019 Omnibus Equity Incentive Plan. Incorporated by reference Exhibit 4.3 to the Registration Statement on Form S-8 filed on August 5, 2020 (File No. 333-240397). |
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10.3** |
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Amended and Restated Amendment to Development and Option Agreement, dated as of September 28, 2018, by and between CureVac AG and Arcturus Therapeutics Inc. Incorporated by reference to Exhibit 99.2 to the Company’s Report of Foreign Private Issuer on Form 6-K filed on October 1, 2018 (File No. 001-35932). |
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10.4** |
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Research and Exclusive License Agreement, by and between Arcturus Therapeutics, Inc. and Synthetic Genomics, Inc., effective October 24, 2017. Incorporated by reference to Exhibit 4.8 to Form 20-F filed on May 14, 2018 (File No. 001-35932). |
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10.5** |
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Research Collaboration and License Agreement, by and between Arcturus Therapeutics, Inc. and Ultragenyx Pharmaceutical Inc., entered into as of October 26, 2015, as amended October 17, 2017 and April 20, 2018. Incorporated by reference to Exhibit 4.10 to Form 20-F filed on May 14, 2018 (File No. 001-35932). |
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10.6** |
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Third Amendment to Research Collaboration and License Agreement, by and between Arcturus Therapeutics, Inc. and Ultragenyx Pharmaceutical Inc., effective June 18, 2019. Incorporated by reference to Exhibit 10.2 to Form 8-K filed on June 20, 2019 (File No. 001- 38942). |
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10.7** |
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Letter Agreement, by and between Arcturus Therapeutics, Inc. and the Cystic Fibrosis Foundation, dated May 16, 2017. Incorporated by reference to Exhibit 4.11 to Form 20-F filed on May 14, 2018 (File No. 001-35932). |
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10.8** |
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Amendment No. 2 to Letter Agreement, by and between Arcturus Therapeutics, Inc. and the Cystic Fibrosis Foundation, dated August 1, 2019. Incorporated by reference to Exhibit 10.16 to Form 10-Q filed on August 14, 2019. |
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10.9** |
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Development and Option Agreement, by and between Arcturus Therapeutics, Inc. and CureVac AG, dated January 1, 2018, as amended May 3, 2018. Incorporated by reference to Exhibit 4.12 to Form 20-F filed on May 14, 2018 (File No. 001-35932). |
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10.10** |
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Third Amendment to Development and Option Agreement, by and between Arcturus Therapeutics, Inc. and CureVac AG, dated July 26, 2019. Incorporated by reference to Exhibit 10.20 to Form 10-Q filed on August 14, 2019 (File No. 001-38942). |
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10.11** |
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License Agreement, by and between Arcturus Therapeutics, Inc., as successor-in-interest to Marina Biotech, Inc., and Protiva Biotherapeutics Inc., dated as of November 28, 2012. Incorporated by reference to Exhibit 4.14 to Form 20-F/A filed on July 10, 2018 (File No. 001-35932). |
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10.12** |
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Patent Assignment and License Agreement, by and between Arcturus Therapeutics, Inc. and Marina Biotech, Inc., dated as of August 9, 2013. Incorporated by reference to Exhibit 4.15 to Form 20-F filed on May 14, 2018 (File No. 001-35932). |
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10.13 |
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Share Exchange Agreement, dated as of February 11, 2019, by and between Arcturus Therapeutics Ltd. and Arcturus Therapeutics Holdings Inc. Incorporated by reference to Exhibit 10.13 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2018 filed on March 18, 2019 (File No. 001-35932). |
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10.14 |
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Lease Agreement, by and between Arcturus Therapeutics, Inc. and ARE-SD Region No. 44, LLC, dated October 4, 2017. Incorporated by reference to Exhibit 4.6 to Form 20-F filed on May 14, 2018 (File No. 001-35932). |
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10.15 |
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First Amendment to Lease Agreement, by and between Arcturus Therapeutics Holdings Inc. and ARE-SD Region No. 44, LLC dated February 1, 2020. Incorporated by reference to Exhibit 10.23 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2019 filed on March 16, 2020 (File No. 001-38942). |
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10.16** |
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Acceptance Letter, dated March 4, 2020, by and between Arcturus Therapeutics Holdings Inc. and the Economic Development Board of Singapore. Incorporated by reference to Exhibit 10.24 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2019 filed on March 16, 2020 (File No. 001-38942). |
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10.17 |
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2020 Employee Stock Purchase Plan. Incorporated by reference to Exhibit 4.3 to Form S-8 filed on August 5, 2020 (File No. 333-240392). |
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10.18 |
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Second Amendment to Lease, by and between Arcturus Therapeutics, Inc. and ARE-SD Region No. 44, LLC, dated November 13, 2020. Incorporated by reference to Exhibit 10.29 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2020 filed on March 1, 2020 (File No. 001-38942). |
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10.19 |
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Third Amendment to Lease, by and between Arcturus Therapeutics, Inc. and ARE-SD Region No. 44, LLC, dated February 25, 2021. Incorporated by reference to Exhibit 10.30 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2020 filed on March 1, 2020 (File No. 001-38942). |
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10.20 |
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Arcturus Therapeutics Holdings Inc. Severance Policy for Executives. Incorporated by reference to Exhibit 10.1 to Current Report on Form 8-K filed on April 26, 2021 (File No. 001-38942). |
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10.21 |
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Lease, by and between Arcturus Therapeutics, Inc. and TPSC IX, LLC, dated September 29, 2021. Incorporated by reference to Exhibit 10.35 to Form 10-Q filed on November 9, 2021 (File No. 001-38942). |
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10.22 |
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Arcturus Therapeutics Holdings Inc. 2021 Inducement Equity Incentive Plan. Incorporated by reference to Exhibit 4.1 to the Registration Statement on Form S-8 filed on October 20, 2021 (File No. 333-260391). |
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10.23 |
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Amended and Restated 2019 Omnibus Equity Incentive Plan, as amended. Incorporated by reference to Exhibit 4.3 to the Registration Statement on Form S-8 filed on June 30, 2022. |
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10.24** |
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Cost Reimbursement Contract dated August 31, 2022, by and between Arcturus Therapeutics Holdings Inc. and Biomedical Advanced Research and Development Authority of the U.S. Department of Health and Human Services. Incorporated by reference to Exhibit 10.36 to Quarterly Report on Form 10-Q filed on November 9, 2022 (File No. 001-38942). |
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10.25** |
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Study Support Agreement, dated October 31, 2022, by and between Arcturus Therapeutics, Inc. and Vinbiocare Research and Manufacture Joint Stock Company. Incorporated by reference to Exhibit 10.1 to Current Report on Form 8-K filed on November 4, 2022 (File No. 001-38942). |
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10.26** |
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Collaboration and License Agreement, dated November 1, 2022, by and between Arcturus Therapeutics Holdings Inc. and CSL Limited. Incorporated by reference to Exhibit 10.38 to Quarterly Report on Form 10-Q filed on November 9, 2022 (File No. 001-38942). |
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10.27** |
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Manufacturing Support Agreement Termination Letter, dated March 23, 2023, by and between Arcturus Therapeutics, Inc. and the Economic Development of Singapore. Incorporated by reference to Exhibit 10.41 to Annual Report on Form 10-K filed on March 29, 2023 (File No. 001-38942). |
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10.28** |
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Credit Agreement dated April 21, 2023, by and between Arcturus Therapeutics, Inc. and Wells Fargo Bank, National Association. Incorporated by reference to Exhibit 10.28 to Quarterly Report on Form 10-Q filed on May 9, 2023 (File No. 001-38942). |
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10.29** |
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Security Agreement dated April 21, 2023, by and between Arcturus Therapeutics, Inc. and Wells Fargo Bank, National Association. Incorporated by reference to Exhibit 10.29 to Quarterly Report on Form 10-Q filed on May 9, 2023 (File No. 001-38942). |
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10.30** |
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Revolving Line of Credit Note dated April 21, 2023, by and between Arcturus Therapeutics, Inc. and Wells Fargo Bank, National Association. Incorporated by reference to Exhibit 10.30 to Quarterly Report on Form 10-Q filed on May 9, 2023 (File No. 001-38942). |
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10.31** |
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Amendment Number One to Collaboration and License Agreement, dated August 3, 2023, by and between Arcturus Therapeutics, Inc. and Seqirus Inc. Incorporated by reference to Exhibit 10.31 to Quarterly Report on Form 10-Q filed on November 14, 2023 (File No. 001-38942). |
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10.32** |
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Amendment No. 4 to Letter Agreement, dated September 25, 2023, by and between Arcturus Therapeutics, Inc. and the Cystic Fibrosis Foundation. Incorporated by reference to Exhibit 10.32 to Quarterly Report on Form 10-Q filed on November 14, 2023 (File No. 001-38942). |
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10.33** |
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Amendment Number Two to Collaboration and License Agreement, dated March 29, 2024, by and between Arcturus Therapeutics, Inc. and Seqirus Inc. Incorporated by reference to Exhibit 10.33 to Quarterly Report on Form 10-Q filed on May 8, 2024 (File No. 001-38942). |
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10.34 |
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Amended and Restated 2019 Omnibus Equity Incentive Plan, as amended. Incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on June 14, 2024 (File No. 001-38942). |
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10.35* |
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First Amendment to Credit Agreement and First Amendment to Revolving Line of Credit, dated June 26, 2024, by and between Arcturus Therapeutics, Inc. and Wells Fargo Bank, National Association. |
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31.1* |
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Certification of Principal Executive Officer Pursuant to Rule 13a-14(a) or 15d-14(a) under the Securities Exchange Act of 1934, as amended. |
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31.2* |
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Certification by Principal Financial Officer pursuant to Rule 13a-14(a) or 15d-14(a) under the Securities Exchange Act of 1934, as amended. |
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32.1* |
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Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
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32.2* |
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Certification of Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
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101* |
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The following financial statements and footnotes from the Registrant’s Quarterly Report on Form 10-Q for the fiscal quarter ended June 30, 2024 formatted in Inline Extensible Business Reporting Language (Inline XBRL): |
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101.INS Inline XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document |
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101.SCH Inline XBRL Taxonomy Extension Schema |
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101.CAL Inline XBRL Taxonomy Extension Calculation Linkbase |
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101.DEF Inline XBRL Taxonomy Extension Definition Linkbase |
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101.LAB Inline XBRL Taxonomy Extension Label Linkbase |
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101.PRE Inline XBRL Taxonomy Extension Presentation Linkbase |
104 |
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Cover Page Interactive Data File (embedded within the Inline XBRL document) |
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* Filed herewith.
** Certain confidential portions of this exhibit have been redacted from the publicly filed document because such portions are (i) not material and (ii) would be competitively harmful of publicly disclosed.
Management compensatory plan, contract or arrangement.
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
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ARCTURUS THERAPEUTICS HOLDINGS INC. |
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Date: August 5, 2024 |
By: |
/s/ Andy Sassine |
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Andy Sassine |
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Chief Financial Officer Principal Financial and Accounting Officer |
CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL
Exhibit 10.35
First Amendment to Credit Agreement
and First Amendment to Revolving Line of Credit Note
This First Amendment to Credit Agreement and First Amendment to Revolving Line of Credit Note (the “Amendment”) is entered into as of June 26, 2024 (the “Amendment Effective Date”), by and among ARCTURUS THERAPEUTICS, INC., a Delaware corporation (“Borrower”) and WELLS FARGO BANK, NATIONAL ASSOCIATION (the “Bank”).
Recitals:
A. The Borrower and the Bank are party to that certain Credit Agreement dated as of April 21, 2023 (as amended, modified, restated, or supplemented from time to time prior to the date hereof, the “Existing Credit Agreement” and the Existing Credit Agreement as amended hereby, the “Credit Agreement”).
B. Pursuant to the terms of the Existing Credit Agreement, the Borrower delivered to Bank that certain Revolving Line of Credit Note dated as of April 21, 2023 (as amended, modified, restated, or supplemented from time to time prior to the date hereof, the “Existing Note” and the Existing Note as amended hereby, the “Note”).
C. The Borrower has requested that the Bank amend the Existing Credit Agreement and the Existing Note, in each case, to extend the Maturity Date, and the Bank is willing to do so under the terms and conditions set forth herein.
Now, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows:
Section 1.Incorporation of Recitals; Defined Terms. The Borrower acknowledges that the Recitals set forth above are true and correct. This Amendment shall constitute a Loan Document, and the Recitals shall be construed as part of this Amendment. Each capitalized term used but not otherwise defined herein, including capitalized terms used in the introductory paragraph hereof and the Recitals, has the meaning assigned to it in the Existing Credit Agreement.
Section 2.Amendments to Existing Credit Agreement. Subject to the satisfaction of the conditions precedent set forth in Section 4 below, the defined term “Maturity Date” set forth in Section 1.1 of the Existing Credit Agreement is hereby amended and restated in its entirety as follows:
“Maturity Date” means April 21, 2026; provided, however, that if such date is not a Business Day, the Maturity Date shall be the immediately preceding Business Day.
Section 3.Amendments to Existing Note. Subject to the satisfaction of the conditions precedent set forth in Section 4 below, the last sentence of clause (a) of the section titled “BORROWING AND REPAYMENT” of the Existing Note is hereby amended and restated in its entirety as follows:
The outstanding principal balance of this Note shall be due and payable in full on April 21, 2026.
Section 4.Conditions Precedent. The effectiveness of this Amendment is subject to the satisfaction of the following conditions precedent:
4.1.The Borrower and the Bank shall have executed and delivered this Amendment.
4.2.The Bank shall have received, a certificate from the Secretary of Borrower certifying that (a) the resolutions, organizational documents and incumbency previously provided to the Bank pursuant to Section 4.1(a)(ii) of the Existing Credit Agreement remain in full force and effect and have not been amended or otherwise modified from such delivered documents, and (b) the Borrower is in good standing, as certified as of a recent date by the Secretary of State of Delaware.
4.3.The Bank shall have received payment in full of the extension commitment fee of $[***], which shall be due and payable to the Bank on the date hereof, and counsel to the Bank shall have received all reasonable and documented fees and out-of-pocket expenses to the extent accrued and unpaid prior to the Amendment Effective Date.
Section 5.Acknowledgement of Liens. The Borrower hereby acknowledges, confirms, and agrees that the Bank has a valid, enforceable (except as enforceability may be limited by applicable bankruptcy, insolvency, or similar laws affecting the enforcement of creditors’ rights generally or by equitable principles relating to enforceability) and perfected first-priority lien upon and security interest in the Collateral granted to the Bank pursuant to the Loan Documents, and nothing herein contained shall in any manner affect or impair the priority of the Liens created and provided for thereby as to the Obligations which would be secured thereby prior to giving effect to this Amendment.
Section 6.Representations and Warranties of Borrower. To induce the Bank to enter into this Amendment, the Borrower hereby represents and warrants to the Bank that, as of the date hereof: (a) after giving effect to this Amendment, each representation and warranty of the Borrower in each Loan Document, including those in Article III of the Existing Credit Agreement, is true and correct (or, in the case of any representation or warranty not qualified as to materiality, true and correct in all material respects) as of the date hereof, except to the extent that such representation or warranty expressly relates to an earlier date, in which case it is true and correct (or, in the case of any representation or warranty not qualified as to materiality, true and correct in all material respects) as of such earlier date, (b) after giving effect to this Amendment, no Event of Default, and no condition, event or act which with the giving of notice or the passage of time or both would constitute such an Event of Default, has occurred and is continuing or exists, or would result herefrom, and (c) the Borrower has the power and authority to execute, deliver, and perform
this Amendment and has taken all necessary action to authorize their execution, delivery, and performance of this Amendment.
7.1.Successors and Assigns. This Amendment shall be binding on and shall inure to the benefit of the Borrower and the Bank and their respective successors and assigns. The terms and provisions of this Amendment are for the purpose of defining the relative rights and obligations of the Borrower and the Bank with respect to the transactions contemplated hereby, and there shall be no third-party beneficiaries of any of the terms and provisions of this Amendment.
7.2.Entire Agreement. This Amendment constitutes the entire agreement of the parties with respect to the subject matter hereof and supersedes all other understandings, oral or written, with respect to the subject matter hereof. Except as specifically amended hereby, all of the terms and conditions set forth in the Existing Credit Agreement and the Existing Note shall stand and remain unchanged and in full force and effect. On and after the date hereof, each reference in the Existing Credit Agreement to “this Agreement”, “hereunder”, “hereof”, “herein” or words of like import referring to the Existing Credit Agreement, and each reference in the other Loan Documents to the “Credit Agreement”, “thereunder”, “thereof” or words of like import referring to the Existing Credit Agreement shall mean and be a reference to the Existing Credit Agreement as amended hereby. On and after the date hereof, each reference in the Existing Note to “this Note”, “hereunder”, “hereof’, “herein” or words of like import referring to the Existing Note, and each reference in the other Loan Documents to the “Note”, “thereunder”, “thereof” or words of like import referring to the Existing Note shall mean and be a reference to the Existing Note as amended hereby.
7.3.Headings. Section and sub-section headings in this Amendment are included herein for convenience of reference only and shall not constitute a part of this Amendment for any other purpose.
7.4.Severability. Wherever possible, each provision of this Amendment shall be interpreted in such a manner as to be effective and valid under applicable law, but if any provision of this Amendment shall be prohibited by or invalid under applicable law, such provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Amendment.
7.5.Conflict of Terms. Except as otherwise provided in this Amendment, if any provision contained in this Amendment conflicts with, or is inconsistent with, any provision in any of the Loan Documents, the provision contained in this Amendment shall govern and control.
7.6.Counterparts. This Amendment may be executed in any number of separate counterparts, each of which shall collectively and separately constitute one agreement. Delivery of an executed signature page to this Amendment by facsimile transmission or by
e-mail transmission of an Adobe portable document format file (also known as a “PDF” file) shall be effective as delivery of a manually executed counterpart hereof.
7.7.Incorporation of Credit Agreement. The provisions contained in Sections 8.10 (Governing Law), 8.13 (Arbitration) and 8.15 (Acknowledgement Regarding Any Supported QFCs) of the Credit Agreement are incorporated herein by reference to the same extent as if reproduced herein in their entirety, except with reference to this Amendment rather than the Credit Agreement.
[Signature Pages to Follow]
IN WITNESS WHEREOF, the parties hereto have caused their duly authorized officers to execute and deliver this Amendment as of the date first set forth above.
“Borrower”
Arcturus Therapeutics, Inc.
By Lance Kurata
Name Lance Kurata
Title Chief Legal Officer
[Signature Page to First Amendment to Credit Agreement
and First Amendment to Revolving Line of Credit Note]
“Bank”
Wells Fargo Bank, National Association
By Derek Jensen
Name Derek Jensen
Title Vice President
[Signature Page to First Amendment to Credit Agreement
and First Amendment to Revolving Line of Credit Note]
Exhibit 31.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
I, Joseph E. Payne, certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Arcturus Therapeutics Holdings Inc.;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
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Date: August 5, 2024 |
|
By: |
/s/ Joseph E. Payne |
|
|
|
Joseph E. Payne |
|
|
|
President and Chief Executive Officer |
Exhibit 31.2
CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER
I, Andy Sassine, certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Arcturus Therapeutics Holdings Inc.;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
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Date: August 5, 2024 |
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By: |
/s/ Andy Sassine |
|
|
|
Andy Sassine |
|
|
|
Chief Financial Officer |
Exhibit 32.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
PURSUANT TO
18 U.S.C. SECTION 1350
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
The undersigned, the President and Chief Executive Officer of Arcturus Therapeutics Holdings Inc. (the "Company"), hereby certifies on the date hereof, pursuant to 18 U.S.C. 1350(a), as adopted pursuant to Section 906 of The Sarbanes-Oxley Act of 2002, that the Quarterly Report on Form 10-Q for the period ended June 30, 2024 (the "Form 10-Q"), filed concurrently herewith by the Company, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, and that the information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of the Company.
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Date: August 5, 2024 |
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By: |
/s/ Joseph E. Payne |
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|
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Joseph E. Payne |
|
|
|
President and Chief Executive Officer |
Exhibit 32.2
CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER
PURSUANT TO
18 U.S.C. SECTION 1350
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
The undersigned, the Chief Financial Officer of Arcturus Therapeutics Holdings Inc. (the "Company"), hereby certifies on the date hereof, pursuant to 18 U.S.C. 1350(a), as adopted pursuant to Section 906 of The Sarbanes-Oxley Act of 2002, that the Quarterly Report on Form 10-Q for the period ended June 30, 2024 (the "Form 10-Q"), filed concurrently herewith by the Company, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, and that the information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of the Company.
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Date: August 5, 2024 |
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By: |
/s/ Andy Sassine |
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Andy Sassine |
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Chief Financial Officer |
v3.24.2.u1
Document and Entity Information - shares
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6 Months Ended |
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Jun. 30, 2024 |
Aug. 02, 2024 |
Cover [Abstract] |
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2024
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Document Fiscal Period Focus |
Q2
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Trading Symbol |
ARCT
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Entity Registrant Name |
ARCTURUS THERAPEUTICS HOLDINGS INC.
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Entity Central Index Key |
0001768224
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Entity Current Reporting Status |
Yes
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Yes
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Current Fiscal Year End Date |
--12-31
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false
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false
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false
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Title of 12(b) Security |
Common Stock, par value $0.001 per share
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NASDAQ
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Entity File Number |
001-38942
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Entity Incorporation, State or Country Code |
DE
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32-0595345
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Entity Address, Address Line One |
10628 Science Center Drive
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Suite 250
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San Diego
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CA
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v3.24.2.u1
CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Current assets: |
|
|
Cash and cash equivalents |
$ 260,329
|
$ 292,005
|
Restricted cash |
55,000
|
55,000
|
Accounts receivable |
24,085
|
32,064
|
Prepaid expenses and other current assets |
7,594
|
7,521
|
Total current assets |
347,008
|
386,590
|
Property and equipment, net |
11,182
|
12,427
|
Operating lease right-of-use assets, net |
28,533
|
28,500
|
Non-current restricted cash |
1,885
|
1,885
|
Total assets |
388,608
|
429,402
|
Current liabilities: |
|
|
Accounts payable |
13,905
|
5,279
|
Accrued liabilities |
35,450
|
31,881
|
Deferred revenue |
42,362
|
44,829
|
Total current liabilities |
91,717
|
81,989
|
Deferred revenue, net of current portion |
11,344
|
42,496
|
Operating lease liability, net of current portion |
26,964
|
25,907
|
Other non-current liabilities |
|
497
|
Total liabilities |
130,025
|
150,889
|
Stockholders’ equity |
|
|
Common stock, $0.001 par value; 60,000 shares authorized; issued and outstanding shares were 27,042 at June 30, 2024 and 26,828 at December 31, 2023 |
27
|
27
|
Additional paid-in capital |
670,455
|
646,352
|
Accumulated deficit |
(411,899)
|
(367,866)
|
Total stockholders’ equity |
258,583
|
278,513
|
Total liabilities and stockholders’ equity |
$ 388,608
|
$ 429,402
|
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v3.24.2.u1
CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares
|
Jun. 30, 2024 |
Dec. 31, 2023 |
Statement of Financial Position [Abstract] |
|
|
Common stock, par value |
$ 0.001
|
$ 0.001
|
Common stock, shares authorized |
60,000,000
|
60,000,000
|
Common stock, shares issued |
27,042,000
|
26,828,000
|
Common stock, shares outstanding |
27,042,000
|
26,828,000
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.24.2.u1
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Revenue: |
|
|
|
|
Total revenue |
$ 49,859
|
$ 10,519
|
$ 87,871
|
$ 90,804
|
Operating expenses: |
|
|
|
|
Research and development, net |
58,669
|
52,668
|
112,242
|
104,436
|
General and administrative |
12,316
|
13,225
|
27,167
|
26,987
|
Total operating expenses |
70,985
|
65,893
|
139,409
|
131,423
|
Loss from operations |
(21,126)
|
(55,374)
|
(51,538)
|
(40,619)
|
(Loss) gain from foreign currency |
(388)
|
149
|
(441)
|
(179)
|
Gain on debt extinguishment |
|
|
|
33,953
|
Finance income, net |
4,148
|
3,252
|
8,164
|
5,729
|
Net loss before income taxes |
(17,366)
|
(51,973)
|
(43,815)
|
(1,116)
|
Provision for income taxes |
(150)
|
577
|
218
|
680
|
Net loss |
$ (17,216)
|
$ (52,550)
|
$ (44,033)
|
$ (1,796)
|
Net loss per share: |
|
|
|
|
Basic |
$ (0.64)
|
$ (1.98)
|
$ (1.64)
|
$ (0.07)
|
Diluted |
$ (0.64)
|
$ (1.98)
|
$ (1.64)
|
$ (0.07)
|
Weighted-average shares outstanding: |
|
|
|
|
Basic |
26,967
|
26,563
|
26,923
|
26,557
|
Diluted |
26,967
|
26,563
|
26,923
|
26,557
|
Comprehensive loss: |
|
|
|
|
Net loss |
$ (17,216)
|
$ (52,550)
|
$ (44,033)
|
$ (1,796)
|
Comprehensive loss |
(17,216)
|
(52,550)
|
(44,033)
|
(1,796)
|
Collaboration Revenue [Member] |
|
|
|
|
Revenue: |
|
|
|
|
Total revenue |
45,976
|
9,565
|
78,574
|
89,294
|
Grant Revenue [Member] |
|
|
|
|
Revenue: |
|
|
|
|
Total revenue |
$ 3,883
|
$ 954
|
$ 9,297
|
$ 1,510
|
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v3.24.2.u1
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands |
Total |
Common Stock [Member] |
Additional Paid-In Capital [Member] |
Accumulated Deficit [Member] |
Balance at Dec. 31, 2022 |
$ 270,312
|
$ 27
|
$ 608,426
|
$ (338,141)
|
Balance (in shares) at Dec. 31, 2022 |
|
26,555
|
|
|
Net Income (Loss) |
50,754
|
|
|
50,754
|
Share-based compensation expense |
8,182
|
|
8,182
|
|
Balance at Mar. 31, 2023 |
329,248
|
$ 27
|
616,608
|
(287,387)
|
Balance (in shares) at Mar. 31, 2023 |
|
26,555
|
|
|
Balance at Dec. 31, 2022 |
270,312
|
$ 27
|
608,426
|
(338,141)
|
Balance (in shares) at Dec. 31, 2022 |
|
26,555
|
|
|
Net Income (Loss) |
(1,796)
|
|
|
|
Balance at Jun. 30, 2023 |
285,175
|
$ 27
|
625,085
|
(339,937)
|
Balance (in shares) at Jun. 30, 2023 |
|
26,574
|
|
|
Balance at Mar. 31, 2023 |
329,248
|
$ 27
|
616,608
|
(287,387)
|
Balance (in shares) at Mar. 31, 2023 |
|
26,555
|
|
|
Net Income (Loss) |
(52,550)
|
|
|
(52,550)
|
Share-based compensation expense |
8,383
|
|
8,383
|
|
Issuance of common stock upon exercise of stock options |
94
|
|
94
|
|
Issuance of common stock upon exercise of stock options (in shares) |
|
19
|
|
|
Balance at Jun. 30, 2023 |
285,175
|
$ 27
|
625,085
|
(339,937)
|
Balance (in shares) at Jun. 30, 2023 |
|
26,574
|
|
|
Balance at Dec. 31, 2023 |
278,513
|
$ 27
|
646,352
|
(367,866)
|
Balance (in shares) at Dec. 31, 2023 |
|
26,828
|
|
|
Net Income (Loss) |
(26,817)
|
|
|
(26,817)
|
Share-based compensation expense |
10,088
|
|
10,088
|
|
Issuance of common stock upon exercise of stock options |
2,188
|
|
2,188
|
|
Issuance of common stock upon exercise of stock options (in shares) |
|
89
|
|
|
Balance at Mar. 31, 2024 |
263,972
|
$ 27
|
658,628
|
(394,683)
|
Balance (in shares) at Mar. 31, 2024 |
|
26,917
|
|
|
Balance at Dec. 31, 2023 |
278,513
|
$ 27
|
646,352
|
(367,866)
|
Balance (in shares) at Dec. 31, 2023 |
|
26,828
|
|
|
Net Income (Loss) |
(44,033)
|
|
|
|
Balance at Jun. 30, 2024 |
258,583
|
$ 27
|
670,455
|
(411,899)
|
Balance (in shares) at Jun. 30, 2024 |
|
27,042
|
|
|
Balance at Mar. 31, 2024 |
263,972
|
$ 27
|
658,628
|
(394,683)
|
Balance (in shares) at Mar. 31, 2024 |
|
26,917
|
|
|
Net Income (Loss) |
(17,216)
|
|
|
(17,216)
|
Share-based compensation expense |
9,424
|
|
9,424
|
|
Issuance of common stock upon exercise of stock options |
2,403
|
|
2,403
|
|
Issuance of common stock upon exercise of stock options (in shares) |
|
125
|
|
|
Balance at Jun. 30, 2024 |
$ 258,583
|
$ 27
|
$ 670,455
|
$ (411,899)
|
Balance (in shares) at Jun. 30, 2024 |
|
27,042
|
|
|
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v3.24.2.u1
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Operating activities |
|
|
Net loss |
$ (44,033)
|
$ (1,796)
|
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |
|
|
Depreciation and amortization |
1,813
|
1,315
|
Share-based compensation expense |
19,512
|
16,565
|
Foreign currency translation loss |
441
|
160
|
Gain on debt extinguishment |
|
(33,953)
|
Other non-cash expenses |
|
502
|
Changes in assets and liabilities: |
|
|
Accounts receivable |
7,979
|
(35)
|
Prepaid expense and other assets |
(73)
|
4,712
|
Right-of-use assets |
2,703
|
1,992
|
Accounts payable |
8,626
|
5,593
|
Accrued liabilities |
2,631
|
(2,983)
|
Deferred revenue |
(33,619)
|
24,969
|
Lease liabilities |
(1,679)
|
(2,105)
|
Net cash (used in) provided by operating activities |
(35,699)
|
14,936
|
Investing activities |
|
|
Acquisition of property and equipment |
(568)
|
(1,045)
|
Net cash used in investing activities |
(568)
|
(1,045)
|
Financing activities |
|
|
Proceeds from exercise of stock options |
4,591
|
94
|
Payments on debt obligations |
|
(27,364)
|
Net cash provided by (used in) financing activities |
4,591
|
(27,270)
|
Net decrease in cash, cash equivalents and restricted cash |
(31,676)
|
(13,379)
|
Cash, cash equivalents and restricted cash at beginning of the period |
348,890
|
393,977
|
Cash, cash equivalents and restricted cash at end of the period |
317,214
|
380,598
|
Supplemental disclosure of cash flow information |
|
|
Cash paid for interest |
|
2,102
|
Non-cash investing activities |
|
|
Non-cash asset disposal |
473
|
|
Right-of-use assets acquired through operating leases |
$ 2,736
|
|
Purchase of property and equipment in accounts payable and accrued expenses |
|
$ 577
|
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v3.24.2.u1
Pay vs Performance Disclosure - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Mar. 31, 2024 |
Jun. 30, 2023 |
Mar. 31, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Pay vs Performance Disclosure |
|
|
|
|
|
|
Net Income (Loss) |
$ (17,216)
|
$ (26,817)
|
$ (52,550)
|
$ 50,754
|
$ (44,033)
|
$ (1,796)
|
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v3.24.2.u1
Insider Trading Arrangements
|
3 Months Ended |
Jun. 30, 2024
shares
|
Trading Arrangements, by Individual |
|
Material Terms of Trading Arrangement |
Rule 10b5-1 Trading Arrangements During the three months ended June 30, 2024, none of our directors or officers adopted or terminated a "Rule 10b5-1 trading arrangement" (as defined in Item 408 of Regulation S-K of the Exchange Act) intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act, other than as follows: •Lance Kurata, our Chief Legal Officer, adopted a Rule 10b5-1 trading arrangement as of June 12, 2024. Mr. Kurata's trading arrangement provides for the exercise of up to an aggregate of 35,000 options to purchase shares of common stock and subsequent sale of such underlying shares of common stock, until June 12, 2025.
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|
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|
Rule 10b5-1 Arrangement Adopted |
false
|
Rule 10b5-1 Arrangement Terminated |
false
|
Lance Kurata [Member] |
|
Trading Arrangements, by Individual |
|
Name |
Lance Kurata
|
Title |
Chief Legal Officer
|
Rule 10b5-1 Arrangement Adopted |
true
|
Adoption Date |
June 12, 2024
|
Expiration Date |
June 12, 2025
|
Aggregate Available |
35,000
|
X |
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v3.24.2.u1
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies |
Note 1. Description of Business, Basis of Presentation and Summary of Significant Accounting Policies Description of Business Arcturus Therapeutics Holdings Inc. (the “Company” or "Arcturus") is a global messenger RNA medicines company focused on the development of infectious disease vaccines and significant addressing unmet medical needs within liver and respiratory rare diseases. The Company became a clinical stage company during 2020 when it announced that its Investigational New Drug (“IND”) application for ornithine transcarbamylase (“OTC”) deficiency and its Clinical Trial Application (“CTA”) for candidate LUNAR-COV19 were approved by applicable health authorities. Basis of Presentation The accompanying condensed consolidated financial statements include the accounts of Arcturus and its subsidiaries and are unaudited. All intercompany accounts and transactions have been eliminated in consolidation. These condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, the accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented. Interim financial results are not necessarily indicative of results anticipated for the full year. These condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2023. These condensed consolidated financial statements are prepared in accordance with GAAP, which requires management to make estimates and assumptions regarding the valuation of certain debt and equity instruments, share-based compensation, accruals for liabilities, income taxes, revenue and deferred revenue, leases, and other matters that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting periods. Although these estimates are based on management’s knowledge of current events and actions the Company may undertake in the future, actual results may ultimately differ from these estimates and assumptions. Joint Ventures, Equity Method Investments and Variable Interest Entities Investments for which the Company exercises significant influence, but does not have control are accounted for under the equity method. Equity method investment activity is related to the Company's joint venture in ARCALIS, Inc. with Axcelead, Inc. (“Axcelead”). The Company’s share of the investee's results is presented as either income or loss from equity-method investment in the accompanying condensed consolidated statements of operations and comprehensive loss. Liquidity The Company has incurred significant operating losses since its inception. As of June 30, 2024 and December 31, 2023, the Company had an accumulated deficit of $411.9 million and $367.9 million, respectively. The Company’s activities since inception have consisted principally of research and development activities, general and administrative activities, and raising capital. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before the Company achieves sustainable revenues and profit from operations. From the Company’s inception through June 30, 2024, the Company has funded its operations principally with the proceeds from revenues earned through collaboration agreements, the sale of capital stock, expense reimbursements from government contracts and proceeds from long-term debt. At June 30, 2024, the Company’s balance of cash and cash equivalents, including restricted cash, was $317.2 million. Management believes that it has sufficient working capital on hand to fund operations through at least the next twelve months from the date these condensed consolidated financial statements were available to be issued. There can be no assurance that the Company will be successful in securing additional funding, that the Company’s projections of its future working capital needs will prove accurate, or that any additional funding would be sufficient to continue operations in future years. Segment Information Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance. The Company and its chief operating decision-maker view the Company’s operations and manage its business in one operating segment, which is the research and development of medical applications for the Company’s nucleic acid-focused technology. Revenue Recognition At contract inception, the Company analyzes its collaboration arrangements to assess whether such arrangements involve joint operating activities performed by parties that are both active participants in the activities and exposed to significant risks and rewards dependent on the commercial success of such activities and therefore within the scope of Accounting Standards Codification (“ASC”) Topic 808, Collaborative Arrangements (“ASC 808”). For collaboration arrangements within the scope of ASC 808 that contain multiple elements, the Company first determines which elements of the collaboration reflect a vendor-customer relationship and are therefore within the scope of ASC 606. The Company determines revenue recognition for arrangements within the scope of ASC 606 by performing the following five steps: (i) identify the contract; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when, or as, the company satisfies a performance obligation. The terms of the Company’s revenue agreements include license fees, upfront payments, development or regulatory milestone payments, profit-sharing arrangements, reimbursement for research and development activities, option exercise fees, drug substance and drug product supply fees, consulting and related technology transfer fees and royalties on sales of commercialized products. The event-based milestone payments represent variable consideration, and the Company uses the most likely amount method to estimate this variable consideration because the Company will either receive the milestone payment or will not, which makes the potential milestone payment a binary event. The most likely amount method requires the Company to determine the likelihood of earning the milestone payment. Given the high degree of uncertainty around achievement of these milestones, the Company determines the milestone amounts to be fully constrained and does not recognize revenue until the uncertainty associated with these payments is resolved. The Company will recognize revenue from sales-based royalty payments when or as the sales occur. The Company will re-evaluate the transaction price in each reporting period as uncertain events are resolved and other changes in circumstances occur. A performance obligation is a promise in a contract to transfer a distinct good or service to the collaborative partner and is the unit of account in ASC 606. A contract’s transaction price is allocated to each distinct performance obligation based on relative standalone selling price and recognized as revenue when, or as, the performance obligation is satisfied. For performance obligations that are recognized over time, the Company measures the progress using an input method. The input methods used are based on the effort expended or costs incurred toward the satisfaction of the performance obligation. The Company estimates the amount of effort expended, including the time estimated it will take to complete the activities, or costs incurred in a given period, relative to the estimated total effort or costs to satisfy the performance obligation. This approach requires the Company to make numerous estimates and use significant judgment. If estimates or judgments change over the course of the collaboration, a cumulative catch up of revenue is recognized in the period such changes are identified. See “Note 2, Revenue” for specific details surrounding the Company’s arrangements. Leases The Company determines if an arrangement is a lease at inception. Lease right-of-use assets represent the Company's right to use an underlying asset for the lease term and lease liabilities represent the Company's obligation to make lease payments arising from the lease. For operating leases with an initial term greater than 12 months, the Company recognizes operating lease right-of-use assets and operating lease liabilities based on the present value of lease payments over the lease term at the commencement date. Operating lease right-of-use assets are comprised of the lease liability plus any lease payments made and excludes lease incentives. Lease terms include options to renew or terminate the lease when the Company is reasonably certain that the renewal option will be exercised or when it is reasonably certain that the termination option will not be exercised. For the Company's operating leases, if the interest rate used to determine the present value of future lease payments is not readily determinable, the Company estimates its incremental borrowing rate as the discount rate for the lease. The Company's incremental borrowing rate is estimated to approximate the interest rate on a collateralized basis with similar terms and payments, and in similar economic environments. Lease expense for lease payments is recognized on a straight-line basis over the lease term. The Company has elected the practical expedient to not separate lease and non-lease components. See “Note 9, Commitments and Contingencies” for specific details surrounding the Company’s leases. Research and Development Costs, Net All research and development costs are expensed as incurred. Research and development costs consist primarily of salaries, employee benefits, costs associated with preclinical studies and clinical trials (including amounts paid to clinical research organizations and other professional services), in-process research and development expenses, pre-launch inventory and license agreement expenses. Research and development expenses are presented net of any grants. Payments made prior to the receipt of goods or services to be used in research and development are capitalized until the goods are received or the services are performed. The Company records accruals for estimated research and development costs, comprising payments for work performed by third party contractors, laboratories, participating clinical trial sites, and others. Some of these contractors bill monthly based on actual services performed, while others bill periodically based upon achieving certain contractual milestones. For the latter, the Company accrues the expenses as goods or services are used or rendered. Clinical trial activities performed by third parties are accrued and expensed based upon estimates of the proportion of work completed over the life of the individual clinical trial and patient enrollment rates in accordance with agreements established with Clinical Research Organizations ("CROs") and clinical trial sites. Estimates are determined by reviewing contracts, vendor agreements and purchase orders, and through discussions with internal clinical personnel and external service providers as to the progress or stage of completion of trials or services and the agreed-upon fee to be paid for such services. Pre-Launch Inventory Prior to obtaining initial regulatory approval for an investigational product candidate, the Company expenses costs relating to production of inventory as research and development expense in its condensed consolidated statements of operations and comprehensive loss, in the period incurred. When the Company believes regulatory approval and subsequent commercialization of an investigational product candidate is probable, and the Company also expects future economic benefit from the sales of the investigational product candidate to be realized, it will then capitalize the costs of production as inventory. Restricted Cash Restricted cash includes collateral pledged and held at the Company’s securities accounts pursuant to a security agreement with Wells Fargo Bank, National Association (“Wells Fargo”) (Note 5). At June 30, 2024, such collateral amounted to $55.0 million. Restricted cash also includes cash required to be set aside as security for lease payments and to maintain a letter of credit for the benefit of the landlord for the Company’s offices. At June 30, 2024 and 2023, the Company had restricted cash of $1.9 million and $2.1 million, respectively, in conjunction with property leases in San Diego, California, and such restriction is expected to be removed at the end of the lease term. The following table provides a reconciliation of cash and cash equivalents and restricted cash reported within the unaudited condensed consolidated balance sheets that sum to the total of the same such amounts shown in the unaudited condensed consolidated statement of cash flows as of June 30, 2024 and 2023:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
June 30, 2023 |
|
Cash and cash equivalents |
|
$ |
260,329 |
|
|
$ |
323,471 |
|
Restricted cash |
|
|
55,000 |
|
|
|
55,000 |
|
Non-current restricted cash |
|
|
1,885 |
|
|
|
2,127 |
|
Total cash, cash equivalents and restricted cash shown in the statement of cash flows |
|
$ |
317,214 |
|
|
$ |
380,598 |
|
Net Loss per Share Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period, without consideration for common stock equivalents. Diluted net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock and dilutive common stock equivalents outstanding for the period determined using the treasury-stock method. Dilutive shares of common stock for the three and six months ended June 30, 2024 were comprised of stock options and restricted stock units. Dilutive shares of common stock for the three and six months ended June 30, 2023 were comprised of stock options. No dividends were declared or paid during the reported periods. Recently Issued Accounting Standards Not Yet Adopted From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board or other standard setting bodies and adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on the condensed consolidated financial statements and disclosures.
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- DefinitionThe entire disclosure for the general note to the financial statements for the reporting entity which may include, descriptions of the basis of presentation, business description, significant accounting policies, consolidations, reclassifications, new pronouncements not yet adopted and changes in accounting principles.
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v3.24.2.u1
Revenue
|
6 Months Ended |
Jun. 30, 2024 |
Revenue from Contract with Customer [Abstract] |
|
Revenue |
Note 2. Revenue The Company has entered into license agreements and collaborative research and development arrangements with pharmaceutical and biotechnology companies, as well as consulting, related technology transfer, product revenue and government grant agreements. Under these arrangements, the Company is entitled to receive license fees, consulting fees, product fees, technological transfer fees, upfront payments, milestone payments if and when certain research and development milestones, technology transfer milestones or success-based milestones are achieved, royalties on approved product sales and reimbursement for research and development activities. The Company’s costs of performing these services are included within research and development expenses. The Company’s milestone payments are typically defined by achievement of certain preclinical, clinical, and commercial success criteria. Preclinical milestones may include in vivo proof of concept in disease animal models, lead candidate identification, and completion of IND-enabling toxicology studies. Clinical milestones may, for example, include successful enrollment of the first patient in or completion of Phase 1, 2 and 3 clinical trials, and commercial milestones are often tiered based on net or aggregate sale amounts. The Company cannot guarantee the achievement of these milestones due to risks associated with preclinical and clinical activities required for development of nucleic acid medicine-based therapeutics and vaccines. The following table presents changes during the six months ended June 30, 2024 in the balances of contract assets and liabilities as compared to what was disclosed in the Company’s Annual Report.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(in thousands) |
|
December 31, 2023 |
|
|
Additions |
|
|
Deductions |
|
|
June 30, 2024 |
|
Contract Assets: |
|
|
|
|
|
|
|
|
|
|
|
|
Accounts receivable |
|
$ |
32,064 |
|
|
$ |
55,132 |
|
|
$ |
(63,111 |
) |
|
$ |
24,085 |
|
Contract Liabilities: |
|
|
|
|
|
|
|
|
|
|
|
|
Deferred revenue |
|
$ |
87,325 |
|
|
$ |
54,252 |
|
|
$ |
(87,871 |
) |
|
$ |
53,706 |
|
The following table summarizes the Company’s revenues for the periods indicated.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Three Months Ended June 30, |
|
|
For the Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Collaboration Revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
CSL Seqirus |
|
$ |
45,911 |
|
|
$ |
7,607 |
|
|
$ |
78,292 |
|
|
$ |
85,824 |
|
Janssen |
|
|
— |
|
|
|
170 |
|
|
|
— |
|
|
|
660 |
|
Other collaboration revenue |
|
|
65 |
|
|
|
1,788 |
|
|
|
282 |
|
|
|
2,810 |
|
Total collaboration revenue |
|
$ |
45,976 |
|
|
$ |
9,565 |
|
|
$ |
78,574 |
|
|
$ |
89,294 |
|
Grant revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
BARDA |
|
$ |
3,883 |
|
|
$ |
954 |
|
|
$ |
9,297 |
|
|
$ |
1,510 |
|
Total grant revenue |
|
$ |
3,883 |
|
|
$ |
954 |
|
|
$ |
9,297 |
|
|
$ |
1,510 |
|
The following paragraphs provide information regarding the nature and purpose of the Company’s most significant collaboration and grant arrangements. CSL Seqirus On November 1, 2022, the Company entered into a Collaboration and License Agreement (as amended, the “CSL Collaboration Agreement”) with Seqirus, Inc., a part of CSL Limited (“CSL Seqirus”), for the global exclusive rights to research, develop, manufacture, and commercialize vaccines. Under the terms of the CSL Collaboration Agreement, the Company provides CSL Seqirus with an exclusive global license to its mRNA technology (including STARR®) and LUNAR® lipid-mediated delivery, along with mRNA drug substance and drug product manufacturing process. CSL Seqirus will lead development and commercialization of vaccines under the collaboration. The collaboration plans to advance vaccines against SARS-CoV-2 (COVID-19), influenza, pandemic preparedness as well as three other respiratory infectious diseases. The Company received a $200.0 million upfront payment and is eligible to receive over $1.3 billion in development milestones if all products are registered in the licensed fields and entitled to potentially receive up to $3.0 billion in commercial milestones based on “net sale” of vaccines in the various fields. In addition, the Company is eligible to receive a 40% net profit share for COVID-19 vaccine products and up to low double-digit royalties for vaccines against flu, pandemic preparedness and three other respiratory pathogens. During the second quarter of 2024, the Company achieved a $17.0 million development milestone related to the CSL Collaboration Agreement which was included in accounts receivable as of June 30, 2024. In evaluating the CSL Collaboration Agreement in accordance with ASC 606, the Company concluded that CSL Seqirus is a customer. The Company identified all promised goods/services within the CSL Collaboration Agreement, and when combining certain promised goods/services, the Company concluded that there are five distinct performance obligations. The nature of the performance obligations consists of delivery of the vaccine license, research and development services for COVID and non-COVID vaccines and regulatory activities for COVID vaccines. For each performance obligation, the Company estimated the standalone selling price based on 1) in the case of the license, the fair value using costs to recreate plus margin method and 2) in the case of research and development services and regulatory activities, cost plus margin for estimated full-time equivalent (“FTE”) costs, direct costs including laboratory supplies, contractors, and other out-of-pocket expenses for research and development services and regulatory activities. As of June 30, 2024, the transaction price consisted of upfront consideration received and milestones achieved. Additional variable consideration was not included in the transaction price at June 30, 2024 because the Company could not conclude that it is probable that including the variable consideration will not result in a significant revenue reversal. The Company allocated the transaction price to the performance obligations in proportion to their standalone selling price. The vaccine license was recognized at the point in time it was transferred in 2022. The research and development and regulatory activities performance obligations are recognized over a period of time based on the percentage of services rendered using the input method, meaning actual costs incurred divided by total costs budgeted to satisfy the performance obligation. Any consideration related to sales-based royalties will be recognized when the amounts are probable of non-reversal, provided that the reported sales are reliably measurable and the Company has no remaining promised goods/services, as they are constrained and therefore have also been excluded from the transaction price. The revenue recognized in the second quarter of 2024 relates to the license delivered, milestones achieved and services performed through June 30, 2024. Total deferred revenue as of June 30, 2024 and December 31, 2023 for the CSL Collaboration Agreement was $53.7 million and $87.1 million, respectively. During 2023, the Company also received an advance payment of $23.6 million for the manufacturing and supply of ARCT-154 drug product. The advance payment was for specified manufacturing runs of ARCT-154 which include the drug substance utilized, as well as the reservation fees and related manufacturing requirements. The Company concluded that the promise to manufacture and supply ARCT-154 drug product is a customer option as part of the CSL Collaboration Agreement and is accounted for as a separate contract. The Company recognized $18.0 million in revenue related to this customer option during the second quarter of 2024. No amount related to this customer option remained in deferred revenue as of June 30, 2024. During 2023, the Company entered into an amendment to the CSL Collaboration Agreement, pursuant to which the Company agreed to sponsor and conduct a Phase 1 clinical study in the influenza field. As part of the amendment, the Company received $17.5 million from CSL Seqirus. The amendment also provides for up to $1.5 million in additional payments which are achievable upon meeting certain clinical milestones relating to the Phase 1 clinical study in the influenza field. The Company previously concluded that the expansion of research and development support services under the CSL Collaboration Agreement represented an option that was not a material right. Therefore the Company concluded the promise to sponsor and conduct the Phase 1 clinical study is a separate contract and the sole performance obligation under the new arrangement. During the quarter ended June 30, 2024, the Company recognized $3.0 million related to the performance obligation and the remaining amount of $9.8 million is included in deferred revenue. During the fourth quarter of 2023, the Company received an advance payment of $5.3 million from CSL Seqirus for manufacturing activities related to COVID-19 vaccine product. During the first quarter of 2024, the Company received an additional advance payment of $5.1 million from CSL Seqirus for manufacturing activities related to COVID-19 vaccine product. The Company concluded that the promise to perform manufacturing activities is a customer option as part of the CSL Collaboration Agreement and is accounted for as a separate contract. The advance payments are included in deferred revenue as of June 30, 2024 and will be recognized as revenue when the vaccine product is transferred to CSL Seqirus. In March 2024, the Company entered into an amendment to the CSL Collaboration Agreement, pursuant to which the parties agreed to, among other things, adjust (i) the development plans for certain product candidates, (ii) various development milestones related to such product candidates, (iii) provisions of the CSL Collaboration Agreement related to specific royalty payments, (iii) provisions of the CSL Collaboration Agreement related to distributors, and (iv) proprietary payment calculations related to the foregoing. BARDA Grant In August 2022, the Company entered into a cost reimbursement contract (the “BARDA Contract”) with the Biomedical Advanced Research and Development Authority ("BARDA"), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS) for an award of up to $63.2 million for the development of a pandemic influenza vaccine using the Company's STARR® self-amplifying mRNA vaccine platform technology. The Company earns grant revenue for performing tasks under the agreement. The Company determined that the BARDA Contract is not in the scope of ASC 808 or ASC 606. Applying International Accounting Standards No. 20 ("IAS 20"), Accounting for Government Grants and Disclosure of Government Assistance, by analogy, the Company recognizes grant revenue from the reimbursement of direct out-of-pocket expenses, overhead allocations and fringe benefits for research costs associated with the grant. The costs associated with these reimbursements are reflected as a component of research and development expense in the Company’s condensed consolidated statements of operations and comprehensive income (loss). The Company recognized $3.9 million and $1.0 million of revenue during the three months ended June 30, 2024 and 2023, respectively. As of June 30, 2024, the remaining available funding net of revenue earned was $44.5 million.
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v3.24.2.u1
Fair Value Measurements
|
6 Months Ended |
Jun. 30, 2024 |
Fair Value Disclosures [Abstract] |
|
Fair Value Measurements |
Note 3. Fair Value Measurements The Company establishes the fair value of its assets and liabilities using the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The Company established a fair value hierarchy based on the inputs used to measure fair value. The three levels of the fair value hierarchy are as follows: Level 1: Quoted prices in active markets for identical assets or liabilities. Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly. Level 3: Unobservable inputs in which little or no market data exists and are therefore determined using estimates and assumptions developed by the Company, which reflect those that a market participant would use. The carrying value of cash, restricted cash, accounts receivable, accounts payable and accrued liabilities approximate their respective fair values due to their relative short maturities. As of June 30, 2024 and December 31, 2023, all assets measured at fair value on a recurring basis consisted of cash equivalents and money market funds, which were classified within Level 1 of the fair value hierarchy. The fair value of these financial instruments was measured based on quoted prices.
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- DefinitionThe entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.
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v3.24.2.u1
Balance Sheet Details
|
6 Months Ended |
Jun. 30, 2024 |
Balance Sheet Related Disclosures [Abstract] |
|
Balance Sheet Details |
Note 4. Balance Sheet Details Property and equipment, net balances consisted of the following:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Research equipment |
|
$ |
16,784 |
|
|
$ |
16,046 |
|
Computers and software |
|
|
1,131 |
|
|
|
1,275 |
|
Office equipment and furniture |
|
|
703 |
|
|
|
958 |
|
Leasehold improvements |
|
|
2,644 |
|
|
|
2,655 |
|
Construction in progress |
|
|
— |
|
|
|
233 |
|
Total |
|
|
21,262 |
|
|
|
21,167 |
|
Less accumulated depreciation and amortization |
|
|
(10,080 |
) |
|
|
(8,740 |
) |
Property and equipment, net |
|
$ |
11,182 |
|
|
$ |
12,427 |
|
Depreciation and amortization expense was $0.9 million and $1.8 million for the three and six months ended June 30, 2024, respectively, and $0.7 million and $1.3 million for the three and six months ended June 30, 2023, respectively. Construction in progress is primarily comprised of research equipment not yet placed in service. Accrued liabilities consisted of the following:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Accrued compensation |
|
$ |
9,206 |
|
|
$ |
5,918 |
|
Cystic Fibrosis Foundation liability |
|
|
6,870 |
|
|
|
7,633 |
|
Income tax payable |
|
|
— |
|
|
|
641 |
|
Current portion of operating lease liability |
|
|
3,917 |
|
|
|
4,309 |
|
Clinical trial accruals |
|
|
968 |
|
|
|
2,333 |
|
Vinbiocare contractual liabilities |
|
|
2,514 |
|
|
|
2,514 |
|
Other accrued research and development expenses |
|
|
11,975 |
|
|
|
8,533 |
|
Total |
|
$ |
35,450 |
|
|
$ |
31,881 |
|
|
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- DefinitionThe entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity.
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v3.24.2.u1
Debt
|
6 Months Ended |
Jun. 30, 2024 |
Debt Disclosure [Abstract] |
|
Debt |
Note 5. Debt Wells Fargo Credit Agreement The Company’s wholly-owned subsidiary, Arcturus Therapeutics, Inc. (“Arcturus Therapeutics”) entered into a credit agreement with Wells Fargo Bank on April 21, 2023, and amended on June 26, 2024, whereby Wells Fargo will make a $50.0 million revolving credit line available to the Company (the “Loan”) and each draw on the Loan evidenced by a revolving line of credit note (the “Note”). Borrowings under the agreement will bear interest at a rate of 1.00% above either the Daily Simple SOFR or Term SOFR (as such terms are defined in the Note), with “SOFR” being the rate per annum equal to the secured overnight financing rate as administered by the Federal Reserve Bank of New York. If an Event of Default (as defined in the agreement) occurs, then all Loans shall bear interest at a rate equal to 2.00% above the interest rate applicable immediately prior to the occurrence of the Event of Default. The term of the agreement was originally two years, with an option for one-year renewals subject to Wells Fargo approval and Arcturus Therapeutics furnishing to Wells Fargo a non-refundable commitment fee equal to 0.25% of the Loan amount for each such renewal. There is no penalty for terminating the facility prior to the maturity date of the Note. As collateral, the Company has agreed to pledge $55.0 million in cash to be held at the Company’s securities accounts with Wells Fargo Securities, LLC, an affiliate of Wells Fargo, pursuant to a security agreement. In June 2024, Arcturus Therapeutics and Wells Fargo entered into an amendment to the Note, whereby the term of the Note was extended by one year to April 2026. No borrowings were outstanding as of June 30, 2024.
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v3.24.2.u1
Stockholders' Equity
|
6 Months Ended |
Jun. 30, 2024 |
Stockholders' Equity Note [Abstract] |
|
Stockholders' Equity |
Note 6. Stockholders’ Equity Net Loss per Share Potentially dilutive securities that were not included in the calculation of diluted net loss per share for the three and six months ended June 30, 2024 as they were anti-dilutive totaled 1.1 million and 1.3 million, respectively, and 1.0 million and 0.8 million for the three and six months ended June 30, 2023, respectively. Sales Agreement On December 23, 2022, the Company entered into a Controlled Equity Offering℠ Sales Agreement, which was amended on August 7, 2023 (as amended, the “Sales Agreement”) with Cantor Fitzgerald & Co. (“Cantor”),Wells Fargo Securities, LLC (“Wells Fargo Securities”), and William Blair & Company, L.L.C. (“William Blair”) relating to shares of the Company's common stock. In accordance with the terms of the Sales Agreement, the Company may offer and sell shares of its common stock having an aggregate offering price of up to $200,000,000 from time to time through Cantor, Wells Fargo Securities, or William Blair, each acting as the Company's sales agent. During the period ended June 30, 2024 the Company did not offer or sell any shares of common stock pursuant to the Sales Agreement.
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v3.24.2.u1
Share-Based Compensation Expense
|
6 Months Ended |
Jun. 30, 2024 |
Share-Based Payment Arrangement [Abstract] |
|
Share-Based Compensation Expense |
Note 7. Share-Based Compensation Expense In June 2024 at the Company’s 2024 Annual Meeting of Stockholders (the "2024 Annual Meeting"), the stockholders of the Company approved an amendment to the Company’s 2019 Omnibus Equity Incentive Plan (as amended, the “2019 Plan”) which, among other things, increased the aggregate number of shares authorized for use in making awards to eligible persons under the 2019 Plan by 2,000,000 shares, for a total of up to 10,750,000 shares available for issuance. As of June 30, 2024, following the 2024 Annual Meeting, a total of 2,236,360 shares remain available for future issuance under the 2019 Plan, subject to the terms of the 2019 Plan. In October 2021, the Company adopted the 2021 Inducement Equity Incentive Plan which covers the award of up to 1,000,000 shares of common stock (the “2021 Plan”) effective as of October 15, 2021. Approval of the Company’s stockholders is not required as a condition to the effectiveness of the 2021 Plan for so long as the plan is in compliance with applicable Nasdaq inducement plan rules. In April 2022, the compensation committee of the Company’s board of directors approved a proposal to reduce the total number of shares available for future issuance under the 2021 Plan to 130,000. As of June 30, 2024, a total of 124,697 shares remain available for future issuance under the 2021 Plan, subject to the terms of the 2021 Plan. Stock Options Share-based compensation expense included in the Company’s condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2024 and 2023 was as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Three Months Ended June 30, |
|
|
|
For the Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
|
2023 |
|
|
|
2024 |
|
|
|
2023 |
|
Research and development |
|
$ |
4,378 |
|
|
|
$ |
3,741 |
|
|
|
$ |
9,180 |
|
|
|
$ |
7,249 |
|
General and administrative |
|
|
5,046 |
|
|
|
|
4,642 |
|
|
|
|
10,332 |
|
|
|
|
9,316 |
|
Total |
|
$ |
9,424 |
|
|
|
$ |
8,383 |
|
|
|
$ |
19,512 |
|
|
|
$ |
16,565 |
|
|
X |
- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.24.2.u1
Income Taxes
|
6 Months Ended |
Jun. 30, 2024 |
Income Tax Disclosure [Abstract] |
|
Income Taxes |
Note 8. Income Taxes The Company is subject to taxation in the United States and various states. The Company computes its quarterly income tax provision by using a forecasted annual effective tax rate and adjusts for any discrete items arising during the quarter. The primary difference between the effective tax rate and the federal statutory tax rate is due to federal and state income tax expense offset by valuation allowance on the Company's deferred tax assets. For the three and six months ended June 30, 2024, the Company recorded $(0.2) million and $0.2 million of income tax expense, respectively. For the three and six months ended June 30, 2023, the Company recorded $0.6 million and $0.7 million of income tax expense, respectively. No tax benefit was provided for losses incurred in United States because those losses are offset by a full valuation allowance.
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- DefinitionThe entire disclosure for income tax.
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v3.24.2.u1
Commitments and Contingencies
|
6 Months Ended |
Jun. 30, 2024 |
Commitments and Contingencies Disclosure [Abstract] |
|
Commitments and Contingencies |
Note 9. Commitments and Contingencies Cystic Fibrosis Foundation Agreement On September 25, 2023, the Company amended its Development Program Letter Agreement, dated May 16, 2017 and as amended July 13, 2018 and August 1, 2019, with the Cystic Fibrosis Foundation (“CFF”). Pursuant to the amendment, CFF increased the amount it will award to advance LUNAR-CF to $24.6 million from approximately $15.6 million and the Company agreed to incur at least $15.0 million toward activities under the research plan. Total contra expense of $0.8 million was recognized during the three and six months ended June 30, 2024. For the three and six months ended June 30, 2023, the Company recognized no contra expense related to the agreement. As of June 30, 2024 and December 31, 2023, $6.9 million and $7.6 million, respectively, remained in accrued liabilities. Leases In October 2017, the Company entered into a non-cancellable operating lease agreement for office space adjacent to its previously occupied headquarters. The commencement of the lease began in March 2018 and the lease extends for approximately 84 months from the commencement date with a remaining lease term through March 2025. Monthly rental payments are due under the lease and there are escalating rent payments during the term of the lease. The Company is also responsible for its proportional share of operating expenses of the building and common areas. In conjunction with the new lease, the Company received free rent for four months and received a tenant improvement allowance of $0.1 million. In March 2024, the Company negotiated with the lessor to extend the lease through March 2027. The Company entered into an irrevocable standby letter of credit with the landlord for a security deposit of $0.1 million upon executing the lease which is included (along with additional funds required to secure the letter of credit) in the balance of non-current restricted cash. In February 2020, the Company entered into a second non-cancellable operating lease agreement for office space near its current headquarters. The lease extended for 13 months from the commencement date and included a right to extend the lease for one twelve-month period. In February 2021, the Company opted to extend the lease through March 2025 to coincide with the lease term of the Company’s headquarters. In January 2024, the Company vacated this office space with no intention of operating out of the location in the future. Because Arcturus was still engaged in the lease for the property and obligated to make the remaining lease payment through March 31, 2025, the Company recorded an impairment loss in the amount of $1.3 million during the three months ended March 31, 2024, as it would not receive any future economic benefit from the lease. In July 2024, the Company terminated the existing lease agreement, in accordance with its terms, thereby ending their contractual obligation to pay for premise. In September 2021, the Company entered into a third non-cancellable lease agreement for office, research and development, engineering and laboratory space near its current headquarters, and such lease term commenced during the second quarter of 2022. The initial term of this lease extends ten years and eight months from the date of possession, and the Company has the right to extend the term of the lease for an additional five-year period. When the lease term was determined for the operating lease right-of-use assets and lease liabilities, the extension option for the lease was not included. The lease has a monthly base rent ranging from $0.3 million to $0.4 million which escalates over the lease term. The Company received a free rent period of four months and also pays for various operating costs, including utilities and real property taxes. The Company entered into an irrevocable standby letter of credit with the landlord for a security deposit of $2.0 million upon executing the lease which is included (along with additional funds required to secure the letter of credit) in the balance of non-current restricted cash. Operating lease right-of-use asset and liability on the condensed consolidated balance sheets represent the present value of remaining lease payments over the remaining lease terms. The Company does not allocate lease payments to non-lease components; therefore, payments for common-area-maintenance and administrative services are not included in the operating lease right-of-use asset and liability. The Company uses its incremental borrowing rate to calculate the present value of the lease payments, as the implicit rate in the lease is not readily determinable. As of June 30, 2024, the remaining payments of the operating lease liability were as follows:
|
|
|
|
|
(in thousands) |
|
Remaining Lease Payments |
|
2024 |
|
$ |
2,838 |
|
2025 |
|
|
5,019 |
|
2026 |
|
|
5,274 |
|
Thereafter |
|
|
23,703 |
|
Total remaining lease payments |
|
|
36,834 |
|
Less: imputed interest |
|
|
(5,953 |
) |
Total operating lease liabilities |
|
$ |
30,881 |
|
Weighted-average remaining lease term |
|
|
7.5 |
|
Weighted-average discount rate |
|
|
4.8 |
% |
Operating lease costs consist of the fixed lease payments included in operating lease liability and are recorded on a straight-line basis over the lease terms. Operating lease costs were $1.5 million and $2.9 million for the three and six months ended June 30, 2024, respectively, and $1.4 million and $2.8 million for the three and six months ended June 30, 2023, respectively.
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- DefinitionThe entire disclosure for commitments and contingencies.
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v3.24.2.u1
Related Party Transactions
|
6 Months Ended |
Jun. 30, 2024 |
Related Party Transactions [Abstract] |
|
Related Party Transactions |
Note 10. Related Party Transactions
See “Note 1, Joint Ventures, Equity Method Investments and Variable Interest Entities” for specific details surrounding the Company’s agreement with Axcelead to form the joint venture entity, ARCALIS, Inc.
|
X |
- DefinitionThe entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.
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v3.24.2.u1
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies (Policies)
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Basis of Presentation |
Basis of Presentation The accompanying condensed consolidated financial statements include the accounts of Arcturus and its subsidiaries and are unaudited. All intercompany accounts and transactions have been eliminated in consolidation. These condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, the accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented. Interim financial results are not necessarily indicative of results anticipated for the full year. These condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2023. These condensed consolidated financial statements are prepared in accordance with GAAP, which requires management to make estimates and assumptions regarding the valuation of certain debt and equity instruments, share-based compensation, accruals for liabilities, income taxes, revenue and deferred revenue, leases, and other matters that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting periods. Although these estimates are based on management’s knowledge of current events and actions the Company may undertake in the future, actual results may ultimately differ from these estimates and assumptions.
|
Joint Ventures, Equity Method Investments and Variable Interest Entities |
Joint Ventures, Equity Method Investments and Variable Interest Entities Investments for which the Company exercises significant influence, but does not have control are accounted for under the equity method. Equity method investment activity is related to the Company's joint venture in ARCALIS, Inc. with Axcelead, Inc. (“Axcelead”). The Company’s share of the investee's results is presented as either income or loss from equity-method investment in the accompanying condensed consolidated statements of operations and comprehensive loss.
|
Liquidity |
Liquidity The Company has incurred significant operating losses since its inception. As of June 30, 2024 and December 31, 2023, the Company had an accumulated deficit of $411.9 million and $367.9 million, respectively. The Company’s activities since inception have consisted principally of research and development activities, general and administrative activities, and raising capital. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before the Company achieves sustainable revenues and profit from operations. From the Company’s inception through June 30, 2024, the Company has funded its operations principally with the proceeds from revenues earned through collaboration agreements, the sale of capital stock, expense reimbursements from government contracts and proceeds from long-term debt. At June 30, 2024, the Company’s balance of cash and cash equivalents, including restricted cash, was $317.2 million. Management believes that it has sufficient working capital on hand to fund operations through at least the next twelve months from the date these condensed consolidated financial statements were available to be issued. There can be no assurance that the Company will be successful in securing additional funding, that the Company’s projections of its future working capital needs will prove accurate, or that any additional funding would be sufficient to continue operations in future years.
|
Segment Information |
Segment Information Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance. The Company and its chief operating decision-maker view the Company’s operations and manage its business in one operating segment, which is the research and development of medical applications for the Company’s nucleic acid-focused technology.
|
Revenue Recognition |
Revenue Recognition At contract inception, the Company analyzes its collaboration arrangements to assess whether such arrangements involve joint operating activities performed by parties that are both active participants in the activities and exposed to significant risks and rewards dependent on the commercial success of such activities and therefore within the scope of Accounting Standards Codification (“ASC”) Topic 808, Collaborative Arrangements (“ASC 808”). For collaboration arrangements within the scope of ASC 808 that contain multiple elements, the Company first determines which elements of the collaboration reflect a vendor-customer relationship and are therefore within the scope of ASC 606. The Company determines revenue recognition for arrangements within the scope of ASC 606 by performing the following five steps: (i) identify the contract; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when, or as, the company satisfies a performance obligation. The terms of the Company’s revenue agreements include license fees, upfront payments, development or regulatory milestone payments, profit-sharing arrangements, reimbursement for research and development activities, option exercise fees, drug substance and drug product supply fees, consulting and related technology transfer fees and royalties on sales of commercialized products. The event-based milestone payments represent variable consideration, and the Company uses the most likely amount method to estimate this variable consideration because the Company will either receive the milestone payment or will not, which makes the potential milestone payment a binary event. The most likely amount method requires the Company to determine the likelihood of earning the milestone payment. Given the high degree of uncertainty around achievement of these milestones, the Company determines the milestone amounts to be fully constrained and does not recognize revenue until the uncertainty associated with these payments is resolved. The Company will recognize revenue from sales-based royalty payments when or as the sales occur. The Company will re-evaluate the transaction price in each reporting period as uncertain events are resolved and other changes in circumstances occur. A performance obligation is a promise in a contract to transfer a distinct good or service to the collaborative partner and is the unit of account in ASC 606. A contract’s transaction price is allocated to each distinct performance obligation based on relative standalone selling price and recognized as revenue when, or as, the performance obligation is satisfied. For performance obligations that are recognized over time, the Company measures the progress using an input method. The input methods used are based on the effort expended or costs incurred toward the satisfaction of the performance obligation. The Company estimates the amount of effort expended, including the time estimated it will take to complete the activities, or costs incurred in a given period, relative to the estimated total effort or costs to satisfy the performance obligation. This approach requires the Company to make numerous estimates and use significant judgment. If estimates or judgments change over the course of the collaboration, a cumulative catch up of revenue is recognized in the period such changes are identified. See “Note 2, Revenue” for specific details surrounding the Company’s arrangements.
|
Leases |
Leases The Company determines if an arrangement is a lease at inception. Lease right-of-use assets represent the Company's right to use an underlying asset for the lease term and lease liabilities represent the Company's obligation to make lease payments arising from the lease. For operating leases with an initial term greater than 12 months, the Company recognizes operating lease right-of-use assets and operating lease liabilities based on the present value of lease payments over the lease term at the commencement date. Operating lease right-of-use assets are comprised of the lease liability plus any lease payments made and excludes lease incentives. Lease terms include options to renew or terminate the lease when the Company is reasonably certain that the renewal option will be exercised or when it is reasonably certain that the termination option will not be exercised. For the Company's operating leases, if the interest rate used to determine the present value of future lease payments is not readily determinable, the Company estimates its incremental borrowing rate as the discount rate for the lease. The Company's incremental borrowing rate is estimated to approximate the interest rate on a collateralized basis with similar terms and payments, and in similar economic environments. Lease expense for lease payments is recognized on a straight-line basis over the lease term. The Company has elected the practical expedient to not separate lease and non-lease components. See “Note 9, Commitments and Contingencies” for specific details surrounding the Company’s leases.
|
Research and Development Costs, Net |
Research and Development Costs, Net All research and development costs are expensed as incurred. Research and development costs consist primarily of salaries, employee benefits, costs associated with preclinical studies and clinical trials (including amounts paid to clinical research organizations and other professional services), in-process research and development expenses, pre-launch inventory and license agreement expenses. Research and development expenses are presented net of any grants. Payments made prior to the receipt of goods or services to be used in research and development are capitalized until the goods are received or the services are performed. The Company records accruals for estimated research and development costs, comprising payments for work performed by third party contractors, laboratories, participating clinical trial sites, and others. Some of these contractors bill monthly based on actual services performed, while others bill periodically based upon achieving certain contractual milestones. For the latter, the Company accrues the expenses as goods or services are used or rendered. Clinical trial activities performed by third parties are accrued and expensed based upon estimates of the proportion of work completed over the life of the individual clinical trial and patient enrollment rates in accordance with agreements established with Clinical Research Organizations ("CROs") and clinical trial sites. Estimates are determined by reviewing contracts, vendor agreements and purchase orders, and through discussions with internal clinical personnel and external service providers as to the progress or stage of completion of trials or services and the agreed-upon fee to be paid for such services.
|
Pre-Launch Inventory |
Pre-Launch Inventory Prior to obtaining initial regulatory approval for an investigational product candidate, the Company expenses costs relating to production of inventory as research and development expense in its condensed consolidated statements of operations and comprehensive loss, in the period incurred. When the Company believes regulatory approval and subsequent commercialization of an investigational product candidate is probable, and the Company also expects future economic benefit from the sales of the investigational product candidate to be realized, it will then capitalize the costs of production as inventory.
|
Restricted Cash |
Restricted Cash Restricted cash includes collateral pledged and held at the Company’s securities accounts pursuant to a security agreement with Wells Fargo Bank, National Association (“Wells Fargo”) (Note 5). At June 30, 2024, such collateral amounted to $55.0 million. Restricted cash also includes cash required to be set aside as security for lease payments and to maintain a letter of credit for the benefit of the landlord for the Company’s offices. At June 30, 2024 and 2023, the Company had restricted cash of $1.9 million and $2.1 million, respectively, in conjunction with property leases in San Diego, California, and such restriction is expected to be removed at the end of the lease term. The following table provides a reconciliation of cash and cash equivalents and restricted cash reported within the unaudited condensed consolidated balance sheets that sum to the total of the same such amounts shown in the unaudited condensed consolidated statement of cash flows as of June 30, 2024 and 2023:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
June 30, 2023 |
|
Cash and cash equivalents |
|
$ |
260,329 |
|
|
$ |
323,471 |
|
Restricted cash |
|
|
55,000 |
|
|
|
55,000 |
|
Non-current restricted cash |
|
|
1,885 |
|
|
|
2,127 |
|
Total cash, cash equivalents and restricted cash shown in the statement of cash flows |
|
$ |
317,214 |
|
|
$ |
380,598 |
|
|
Net Loss per Share |
Net Loss per Share Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period, without consideration for common stock equivalents. Diluted net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock and dilutive common stock equivalents outstanding for the period determined using the treasury-stock method. Dilutive shares of common stock for the three and six months ended June 30, 2024 were comprised of stock options and restricted stock units. Dilutive shares of common stock for the three and six months ended June 30, 2023 were comprised of stock options. No dividends were declared or paid during the reported periods.
|
Recently Issued Accounting Standards Not Yet Adopted |
Recently Issued Accounting Standards Not Yet Adopted From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board or other standard setting bodies and adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on the condensed consolidated financial statements and disclosures.
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v3.24.2.u1
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Schedule of Cash and Cash Equivalents and Restricted Cash |
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
June 30, 2023 |
|
Cash and cash equivalents |
|
$ |
260,329 |
|
|
$ |
323,471 |
|
Restricted cash |
|
|
55,000 |
|
|
|
55,000 |
|
Non-current restricted cash |
|
|
1,885 |
|
|
|
2,127 |
|
Total cash, cash equivalents and restricted cash shown in the statement of cash flows |
|
$ |
317,214 |
|
|
$ |
380,598 |
|
|
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v3.24.2.u1
Revenue (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Revenue from Contract with Customer [Abstract] |
|
Summary of Changes in Balances of Receivables and Contract Liability |
The following table presents changes during the six months ended June 30, 2024 in the balances of contract assets and liabilities as compared to what was disclosed in the Company’s Annual Report.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(in thousands) |
|
December 31, 2023 |
|
|
Additions |
|
|
Deductions |
|
|
June 30, 2024 |
|
Contract Assets: |
|
|
|
|
|
|
|
|
|
|
|
|
Accounts receivable |
|
$ |
32,064 |
|
|
$ |
55,132 |
|
|
$ |
(63,111 |
) |
|
$ |
24,085 |
|
Contract Liabilities: |
|
|
|
|
|
|
|
|
|
|
|
|
Deferred revenue |
|
$ |
87,325 |
|
|
$ |
54,252 |
|
|
$ |
(87,871 |
) |
|
$ |
53,706 |
|
|
Schedule of Revenue |
The following table summarizes the Company’s revenues for the periods indicated.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Three Months Ended June 30, |
|
|
For the Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Collaboration Revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
CSL Seqirus |
|
$ |
45,911 |
|
|
$ |
7,607 |
|
|
$ |
78,292 |
|
|
$ |
85,824 |
|
Janssen |
|
|
— |
|
|
|
170 |
|
|
|
— |
|
|
|
660 |
|
Other collaboration revenue |
|
|
65 |
|
|
|
1,788 |
|
|
|
282 |
|
|
|
2,810 |
|
Total collaboration revenue |
|
$ |
45,976 |
|
|
$ |
9,565 |
|
|
$ |
78,574 |
|
|
$ |
89,294 |
|
Grant revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
BARDA |
|
$ |
3,883 |
|
|
$ |
954 |
|
|
$ |
9,297 |
|
|
$ |
1,510 |
|
Total grant revenue |
|
$ |
3,883 |
|
|
$ |
954 |
|
|
$ |
9,297 |
|
|
$ |
1,510 |
|
|
X |
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v3.24.2.u1
Balance Sheet Details (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Balance Sheet Related Disclosures [Abstract] |
|
Summary of Components of Property and Equipment, Net |
Property and equipment, net balances consisted of the following:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Research equipment |
|
$ |
16,784 |
|
|
$ |
16,046 |
|
Computers and software |
|
|
1,131 |
|
|
|
1,275 |
|
Office equipment and furniture |
|
|
703 |
|
|
|
958 |
|
Leasehold improvements |
|
|
2,644 |
|
|
|
2,655 |
|
Construction in progress |
|
|
— |
|
|
|
233 |
|
Total |
|
|
21,262 |
|
|
|
21,167 |
|
Less accumulated depreciation and amortization |
|
|
(10,080 |
) |
|
|
(8,740 |
) |
Property and equipment, net |
|
$ |
11,182 |
|
|
$ |
12,427 |
|
|
Schedule of Accrued Liabilities |
Accrued liabilities consisted of the following:
|
|
|
|
|
|
|
|
|
(in thousands) |
|
June 30, 2024 |
|
|
December 31, 2023 |
|
Accrued compensation |
|
$ |
9,206 |
|
|
$ |
5,918 |
|
Cystic Fibrosis Foundation liability |
|
|
6,870 |
|
|
|
7,633 |
|
Income tax payable |
|
|
— |
|
|
|
641 |
|
Current portion of operating lease liability |
|
|
3,917 |
|
|
|
4,309 |
|
Clinical trial accruals |
|
|
968 |
|
|
|
2,333 |
|
Vinbiocare contractual liabilities |
|
|
2,514 |
|
|
|
2,514 |
|
Other accrued research and development expenses |
|
|
11,975 |
|
|
|
8,533 |
|
Total |
|
$ |
35,450 |
|
|
$ |
31,881 |
|
|
X |
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v3.24.2.u1
Share-Based Compensation Expense (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Share-Based Payment Arrangement [Abstract] |
|
Schedule of Share-based Compensation Expenses |
Share-based compensation expense included in the Company’s condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2024 and 2023 was as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
For the Three Months Ended June 30, |
|
|
|
For the Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
|
2023 |
|
|
|
2024 |
|
|
|
2023 |
|
Research and development |
|
$ |
4,378 |
|
|
|
$ |
3,741 |
|
|
|
$ |
9,180 |
|
|
|
$ |
7,249 |
|
General and administrative |
|
|
5,046 |
|
|
|
|
4,642 |
|
|
|
|
10,332 |
|
|
|
|
9,316 |
|
Total |
|
$ |
9,424 |
|
|
|
$ |
8,383 |
|
|
|
$ |
19,512 |
|
|
|
$ |
16,565 |
|
|
X |
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Commitments and Contingencies (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Commitments and Contingencies Disclosure [Abstract] |
|
Remaining Payments of Operating Lease Liability |
As of June 30, 2024, the remaining payments of the operating lease liability were as follows:
|
|
|
|
|
(in thousands) |
|
Remaining Lease Payments |
|
2024 |
|
$ |
2,838 |
|
2025 |
|
|
5,019 |
|
2026 |
|
|
5,274 |
|
Thereafter |
|
|
23,703 |
|
Total remaining lease payments |
|
|
36,834 |
|
Less: imputed interest |
|
|
(5,953 |
) |
Total operating lease liabilities |
|
$ |
30,881 |
|
Weighted-average remaining lease term |
|
|
7.5 |
|
Weighted-average discount rate |
|
|
4.8 |
% |
|
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v3.24.2.u1
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies (Details Textual)
|
6 Months Ended |
|
|
|
Jun. 30, 2024
USD ($)
Segment
|
Jun. 30, 2023
USD ($)
|
Jun. 26, 2024
USD ($)
|
Dec. 31, 2023
USD ($)
|
Dec. 31, 2022
USD ($)
|
Summary Of Significant Accounting Policy [Line Items] |
|
|
|
|
|
Accumulated deficit |
$ 411,899,000
|
|
|
$ 367,866,000
|
|
Cash and cash equivalents, including restricted cash |
$ 317,214,000
|
$ 380,598,000
|
|
348,890,000
|
$ 393,977,000
|
Number of operating segment for research and development | Segment |
1
|
|
|
|
|
Non-current restricted cash |
$ 1,885,000
|
2,127,000
|
|
$ 1,885,000
|
|
Dividends declared or paid |
0
|
$ 0
|
|
|
|
Wells Fargo Credit Agreement [Member] |
|
|
|
|
|
Summary Of Significant Accounting Policy [Line Items] |
|
|
|
|
|
Debt instrument, collateral amount |
$ 55,000,000
|
|
$ 55,000,000
|
|
|
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v3.24.2.u1
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies - Schedule of Cash and Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Jun. 30, 2023 |
Dec. 31, 2022 |
Accounting Policies [Abstract] |
|
|
|
|
Cash and cash equivalents |
$ 260,329
|
$ 292,005
|
$ 323,471
|
|
Restricted cash |
55,000
|
|
55,000
|
|
Non-current restricted cash |
1,885
|
1,885
|
2,127
|
|
Total cash, cash equivalents and restricted cash shown in the statement of cash flows |
$ 317,214
|
$ 348,890
|
$ 380,598
|
$ 393,977
|
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v3.24.2.u1
Revenue - Summary of Changes in Balances of Receivables and Contract Liability (Details) $ in Thousands |
6 Months Ended |
Jun. 30, 2024
USD ($)
|
Revenue from Contract with Customer [Abstract] |
|
Accounts receivable, Balance |
$ 32,064
|
Additions |
55,132
|
Deductions |
(63,111)
|
Accounts receivable, Balance |
24,085
|
Deferred revenue, Balance |
87,325
|
Additions |
54,252
|
Deductions |
(87,871)
|
Deferred revenue, Balance |
$ 53,706
|
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v3.24.2.u1
Revenue - Summary of Revenues (Details) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Disaggregation Of Revenue [Line Items] |
|
|
|
|
Total revenue |
$ 49,859
|
$ 10,519
|
$ 87,871
|
$ 90,804
|
Collaboration Revenue [Member] |
|
|
|
|
Disaggregation Of Revenue [Line Items] |
|
|
|
|
Total revenue |
45,976
|
9,565
|
78,574
|
89,294
|
Grant Revenue [Member] |
|
|
|
|
Disaggregation Of Revenue [Line Items] |
|
|
|
|
Total revenue |
3,883
|
954
|
9,297
|
1,510
|
CSL Seqirus [Member] | Collaboration Revenue [Member] |
|
|
|
|
Disaggregation Of Revenue [Line Items] |
|
|
|
|
Total revenue |
45,911
|
7,607
|
78,292
|
85,824
|
Janssen [Member] | Collaboration Revenue [Member] |
|
|
|
|
Disaggregation Of Revenue [Line Items] |
|
|
|
|
Total revenue |
|
170
|
|
660
|
Other Collaboration Revenue [Member] | Collaboration Revenue [Member] |
|
|
|
|
Disaggregation Of Revenue [Line Items] |
|
|
|
|
Total revenue |
65
|
1,788
|
282
|
2,810
|
BARDA [Member] | Grant Revenue [Member] |
|
|
|
|
Disaggregation Of Revenue [Line Items] |
|
|
|
|
Total revenue |
$ 3,883
|
$ 954
|
$ 9,297
|
$ 1,510
|
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v3.24.2.u1
Revenue (Details Textual) - USD ($)
|
|
1 Months Ended |
3 Months Ended |
6 Months Ended |
12 Months Ended |
|
Nov. 01, 2022 |
Aug. 31, 2022 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Dec. 31, 2023 |
Mar. 31, 2024 |
Revenue [Line Items] |
|
|
|
|
|
|
|
Deferred revenue |
|
|
$ 53,706,000
|
|
$ 53,706,000
|
$ 87,325,000
|
|
Revenue recognized |
|
|
|
|
(87,871,000)
|
|
|
BARDA [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Revenue recognized |
|
|
3,900,000
|
$ 1,000,000
|
|
|
|
Total grant revenue |
|
$ 63,200,000
|
|
|
|
|
|
Grant revenue outstanding |
|
|
|
|
44,500,000
|
|
|
Research Collaboration And License Agreement [Member] | Seqirus Inc [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Upfront payment received |
$ 200,000,000
|
|
|
|
|
|
|
Research Collaboration And License Agreement [Member] | Seqirus Inc [Member] | COVID-19 Vaccine [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Net profits percentage |
40.00%
|
|
|
|
|
|
|
Development milestones received advance payment |
|
|
|
|
|
5,300,000
|
$ 5,100,000
|
Research Collaboration And License Agreement [Member] | Seqirus Inc [Member] | Manufacturing and Supply of ARCT-154 Drug Product [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Deferred revenue |
|
|
0
|
|
0
|
|
|
Revenue recognized |
|
|
18,000,000
|
|
|
|
|
Development milestones received advance payment |
|
|
|
|
|
23,600,000
|
|
Research Collaboration And License Agreement [Member] | Maximum [Member] | Seqirus Inc [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Eligible to receive development milestone payment |
$ 1,300,000,000
|
|
|
|
|
|
|
Eligible to receive commercial milestone payment |
$ 3,000,000,000
|
|
|
|
|
|
|
CSL Collaboration Agreement [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Development milestones achieved |
|
|
|
|
17,000,000
|
|
|
Deferred revenue |
|
|
53,700,000
|
|
53,700,000
|
87,100,000
|
|
CSL Collaboration Agreement [Member] | Phase I Clinical Study [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Deferred revenue |
|
|
9,800,000
|
|
9,800,000
|
|
|
Milestone payments |
|
|
|
|
|
17,500,000
|
|
Remaining performance obligation |
|
|
$ 3,000,000
|
|
$ 3,000,000
|
|
|
CSL Collaboration Agreement [Member] | Maximum [Member] | Phase I Clinical Study [Member] |
|
|
|
|
|
|
|
Revenue [Line Items] |
|
|
|
|
|
|
|
Additional payments upon meeting certain clinical milestones |
|
|
|
|
|
$ 1,500,000
|
|
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v3.24.2.u1
Balance Sheet Details - Summary of Components of Property and Equipment, Net (Details) - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Property Plant And Equipment [Line Items] |
|
|
Property and equipment, gross |
$ 21,262
|
$ 21,167
|
Less accumulated depreciation and amortization |
(10,080)
|
(8,740)
|
Property and equipment, net |
11,182
|
12,427
|
Research equipment [Member] |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property and equipment, gross |
16,784
|
16,046
|
Computer and software [Member] |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property and equipment, gross |
1,131
|
1,275
|
Office equipment and furniture [Member] |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property and equipment, gross |
703
|
958
|
Leasehold improvements [Member] |
|
|
Property Plant And Equipment [Line Items] |
|
|
Property and equipment, gross |
$ 2,644
|
2,655
|
Construction in progress [Member] |
|
|
Property Plant And Equipment [Line Items] |
|
|
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|
$ 233
|
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Balance Sheet Details - Schedule of Accrued Liabilities (Details) - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Accrued Liabilities, Current [Abstract] |
|
|
Accrued compensation |
$ 9,206
|
$ 5,918
|
Cystic Fibrosis Foundation liability |
6,870
|
7,633
|
Income tax payable |
|
641
|
Current portion of operating lease liability |
$ 3,917
|
$ 4,309
|
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] |
Total
|
Total
|
Clinical trial accruals |
$ 968
|
$ 2,333
|
Vinbiocare contractual liabilities |
2,514
|
2,514
|
Other accrued research and development expenses |
11,975
|
8,533
|
Total |
$ 35,450
|
$ 31,881
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|
|
1 Months Ended |
Jun. 26, 2024 |
Jun. 30, 2024 |
Debt Instrument [Line Items] |
|
|
Revolving credit line available |
$ 50,000,000
|
|
Loans interest rate, percentage |
2.00%
|
|
Term of agreement |
2 years
|
|
Extended term period |
|
1 year
|
Option for renewal term |
1 year
|
|
Non-refundable commitment fee, percentage |
0.25%
|
|
Long-term debt |
|
$ 0
|
Debt instrument, collateral amount |
$ 55,000,000
|
$ 55,000,000
|
SOFR [Member] |
|
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Debt Instrument [Line Items] |
|
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Loan accrued interest rate per annum, percentage |
1.00%
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v3.24.2.u1
Stockholders' Equity (Details Textual) - USD ($)
|
|
3 Months Ended |
6 Months Ended |
Dec. 23, 2022 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Class Of Stock [Line Items] |
|
|
|
|
|
Antidilutive securities excluded from computation of earnings per share |
|
1,100,000
|
1,000,000
|
1,300,000
|
800,000
|
Wells Fargo Credit Agreement [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Issuance of common stock |
|
|
|
0
|
|
Wells Fargo Credit Agreement [Member] | Maximum [Member] |
|
|
|
|
|
Class Of Stock [Line Items] |
|
|
|
|
|
Common stock issued, value |
$ 200,000,000
|
|
|
|
|
X |
- DefinitionSecurities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.
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v3.24.2.u1
Share-Based Compensation Expense (Details Textual) - shares
|
Jun. 30, 2024 |
Apr. 30, 2022 |
Oct. 15, 2021 |
2019 Omnibus Equity Incentive Plan [Member] |
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
Share-based compensation number of shares authorized |
2,000,000
|
|
|
2019 Omnibus Equity Incentive Plan [Member] | Maximum [Member] |
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
Share-based compensation number of shares authorized |
10,750,000
|
|
|
2019 Omnibus Equity Incentive Plan [Member] | Employee Stock Option [Member] |
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
Common stock reserved for future issuance |
2,236,360
|
|
|
2021 Inducement Equity Incentive Plan [Member] |
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
Reduction in number of common stock shares available for future issuance |
|
130,000
|
|
2021 Inducement Equity Incentive Plan [Member] | Maximum [Member] |
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
Number of shares available |
|
|
1,000,000
|
2021 Inducement Equity Incentive Plan [Member] | Employee Stock Option [Member] |
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
Common stock reserved for future issuance |
124,697
|
|
|
X |
- DefinitionReduction in number of common stock capital shares available for future issuance.
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v3.24.2.u1
Share-Based Compensation Expense (Details) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Share-based compensation expenses |
$ 9,424
|
$ 8,383
|
$ 19,512
|
$ 16,565
|
Research and Development [Member] |
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Share-based compensation expenses |
4,378
|
3,741
|
9,180
|
7,249
|
General and Administrative [Member] |
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Share-based compensation expenses |
$ 5,046
|
$ 4,642
|
$ 10,332
|
$ 9,316
|
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v3.24.2.u1
v3.24.2.u1
Commitments and Contingencies (Details Textual) - USD ($)
|
|
1 Months Ended |
3 Months Ended |
6 Months Ended |
12 Months Ended |
50 Months Ended |
|
Aug. 01, 2019 |
Sep. 30, 2021 |
Oct. 31, 2017 |
Jun. 30, 2024 |
Mar. 31, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Dec. 31, 2023 |
Sep. 25, 2023 |
Feb. 29, 2020 |
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Operating lease costs |
|
|
|
$ 1,500,000
|
|
$ 1,400,000
|
$ 2,900,000
|
$ 2,800,000
|
|
|
|
October 2017 Lease Amendment [Member] |
|
|
|
|
|
|
|
|
|
|
|
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Operating lease extended additional term |
|
|
84 months
|
|
|
|
|
|
|
|
|
Lessee, operating lease, term of contract |
|
|
4 months
|
|
|
|
|
|
|
|
|
Tenant improvement allowance |
|
|
$ 100,000
|
|
|
|
|
|
|
|
|
Security deposit |
|
|
$ 100,000
|
|
|
|
|
|
|
|
|
February 2020 Lease Agreement [Member] |
|
|
|
|
|
|
|
|
|
|
|
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Operating lease extended additional term |
|
|
|
|
|
|
|
|
|
|
13 months
|
Lessee, operating leases, option to extend |
|
|
|
|
|
|
the lease for one twelve-month period. In February 2021, the Company opted to extend the lease through March 2025 to coincide with the lease term of the Company’s headquarters.
|
|
|
|
|
Impairment loss |
|
|
|
|
$ 1,300,000
|
|
|
|
|
|
|
September 2021 Lease Agreement [Member] |
|
|
|
|
|
|
|
|
|
|
|
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Operating lease extended additional term |
|
10 years 8 months
|
|
|
|
|
|
|
|
|
|
Lessee, operating leases, option to extend |
|
|
|
|
|
|
the Company has the right to extend the term of the lease for an additional five-year period.
|
|
|
|
|
Security deposit |
|
$ 2,000,000
|
|
|
|
|
|
|
|
|
|
Underlying Agreement [Member] | Cystic Fibrosis Foundation [Member] |
|
|
|
|
|
|
|
|
|
|
|
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Contra expense remaining amount included in accrued expenses |
|
|
|
|
|
|
$ 6,900,000
|
|
$ 7,600,000
|
|
|
Minimum amount agreed to incur under research plan |
|
|
|
|
|
|
|
|
|
$ 15,000,000
|
|
Contra expense included in research and development expense |
|
|
|
$ 800,000
|
|
$ 0
|
$ 800,000
|
$ 0
|
|
|
|
Underlying Agreement [Member] | LUNAR-CF [Member] | Cystic Fibrosis Foundation [Member] |
|
|
|
|
|
|
|
|
|
|
|
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Payments for advance |
$ 15,600,000
|
|
|
|
|
|
|
|
|
$ 24,600,000
|
|
Maximum [Member] | September 2021 Lease Agreement [Member] |
|
|
|
|
|
|
|
|
|
|
|
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Monthly base rent |
|
400,000
|
|
|
|
|
|
|
|
|
|
Minimum [Member] | September 2021 Lease Agreement [Member] |
|
|
|
|
|
|
|
|
|
|
|
Commitment And Contingencies [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Monthly base rent |
|
$ 300,000
|
|
|
|
|
|
|
|
|
|
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Arcturus Therapeutics (NASDAQ:ARCT)
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Arcturus Therapeutics (NASDAQ:ARCT)
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