As filed with the U.S. Securities and Exchange
Commission on November 13, 2024
Registration No. 333-
UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
FORM S-3
REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OF 1933
Unicycive
Therapeutics, Inc.
(Exact
name of registrant as specified in its charter)
Delaware |
|
81-3638692 |
(State
or other jurisdiction of |
|
(I.R.S.
Employer |
incorporation
or organization) |
|
Identification
Number) |
4300
El Camino Real, Suite 210
Los
Altos, CA 94022
(650)
351-4495
(Address,
including zip code, and telephone number, including area code, of registrant’s principal executive offices)
Shalabh
Gupta, M.D.
Chief
Executive Officer
Unicycive
Therapeutics, Inc.
4300
El Camino Real, Suite 210
Los
Altos, CA 94022
(650)
351-4495
(Name,
address, including zip code, and telephone number, including area code, of agent for service)
With
copies to:
Jeffrey
J. Fessler, Esq.
Greg
Carney, Esq.
Sheppard,
Mullin, Richter & Hampton LLP
30
Rockefeller Plaza
New
York, NY 10112
Tel:
(212) 653-8700
Fax:
(212) 653-8701
Approximate
date of commencement of proposed sale to the public: From time to time, after the effective date of this registration statement.
If
the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check
the following box: ☐
If
any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following
box: ☒
If
this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the
following box and list the Securities Act registration statement number of the earlier effective registration statement for the same
offering. ☐
If
this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐
If
this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective
upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐
If
this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional
securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐
Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,”
“smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
|
Large
accelerated filer ☐ |
|
Accelerated
filer ☐ |
|
Non-accelerated
filer ☒ |
|
Smaller
reporting company ☒ |
|
|
|
Emerging
growth company ☒ |
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of Securities Act. ☐
The
registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the
registrant shall file a further amendment that specifically states that this registration statement shall thereafter become effective
in accordance with Section 8(a) of the Securities Act of 1933 or until this registration statement shall become effective on such date
as the Commission, acting pursuant to said Section 8(a), may determine.
PROSPECTUS
EXPLANATORY NOTE
This registration statement contains two prospectuses:
| ● | a base prospectus which covers the offering, issuance and sale by us
of up to $100 million in the aggregate, subject to certain limitations, of the securities identified above from time to time in one or
more offerings; and |
| ● | a sales agreement prospectus covering the offering, issuance and sale
by us of up to a maximum aggregate offering price of $50 million, subject to certain limitations, of our common stock that may be offered
and sold under a Sales Agreement (the “Sales Agreement”) with Guggenheim Securities, LLC. |
The base prospectus immediately follows this explanatory
note. The specific terms of any securities to be offered pursuant to the base prospectus will be specified in a prospectus supplement
to the base prospectus. The specific terms of the securities to be issued and sold under the Sales Agreement are specified in the sales
agreement prospectus that immediately follows the base prospectus.
The information in this prospectus is not complete
and may be changed. We may not sell these securities or accept an offer to buy these securities until the registration statement filed
with the U.S. Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and we are not
soliciting an offer to buy these securities in any state where the offer or sale is not permitted.
PRELIMINARY PROSPECTUS
Subject to completion, dated November 13, 2024
Unicycive
Therapeutics, Inc.
Common Stock
Preferred Stock
Debt Securities
Warrants
Units
We may offer and sell, from
time to time in one or more offerings, any combination of common stock, preferred stock, debt securities, warrants to purchase common
stock, preferred stock or debt securities, or any combination of the foregoing, either individually or as units comprised of one or more
of the other securities, having an aggregate initial offering price not exceeding $100 million, subject to certain limitations, as described
below.
This prospectus provides a
general description of the securities we may offer. Each time we sell a particular class or series of securities, we will provide
specific terms of the securities offered in a supplement to this prospectus. The prospectus supplement and any related free writing prospectus
may also add, update or change information contained in this prospectus. We may also authorize one or more free writing prospectuses to
be provided to you in connection with these offerings. You should read carefully this prospectus, the applicable prospectus supplement
and any related free writing prospectus, as well as any documents incorporated by reference herein or therein before you invest in any
of our securities.
The specific terms of any
securities to be offered, and the specific manner in which they may be offered, will be described in one or more supplements to this prospectus.
This prospectus may not be used to consummate sales of any of these securities unless it is accompanied by a prospectus supplement. Before
investing, you should carefully read this prospectus and any related prospectus supplement.
Our common stock is presently
listed on The Nasdaq Capital Market under the symbol “UNCY.” On November 8, 2024 the last reported sale price of our common
stock was $0.59 per share. The applicable prospectus supplement will contain information, where applicable, as to any other listing on
The Nasdaq Capital Market or any securities market or other exchange of the securities, if any, covered by the prospectus supplement.
Prospective purchasers of our securities are urged to obtain current information as to the market prices of our securities, where applicable.
These securities may be sold
directly by us, through dealers or agents designated from time to time, to or through underwriters, dealers, or through a combination
of these methods on a continuous or delayed basis. See “Plan of Distribution” in this prospectus. We may also
describe the plan of distribution for any particular offering of our securities in a prospectus supplement. If any agents, underwriters
or dealers are involved in the sale of any securities in respect of which this prospectus is being delivered, we will disclose their names
and the nature of our arrangements with them in a prospectus supplement. The price to the public of such securities and the net proceeds
we expect to receive from any such sale will also be included in a prospectus supplement.
Investing in our securities
involves various risks. See “Risk Factors” contained herein for more information on these risks. Additional risks will
be described in the related prospectus supplements under the heading “Risk Factors.” You should review that section
of the related prospectus supplements for a discussion of matters that investors in our securities should consider.
Neither the U.S. Securities
and Exchange Commission nor any state securities commission has approved or disapproved of these securities, or passed upon the adequacy
or accuracy of this prospectus or any accompanying prospectus supplement. Any representation to the contrary is a criminal offense.
The date of this prospectus is November , 2024.
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS
This prospectus is part of
a registration statement that we filed with the U.S. Securities and Exchange Commission, or SEC, using a “shelf” registration
process. Under this shelf registration statement, we may sell from time to time in one or more offerings of common stock and preferred
stock, various series of debt securities and/or warrants to purchase any of such securities, either individually or as units comprised
of a combination of one or more of the other securities in one or more offerings up to a total dollar amount of $100 million. This prospectus
provides you with a general description of the securities we may offer. Each time we sell any type or series of securities under this
prospectus, we will provide a prospectus supplement that will contain more specific information about the terms of that offering.
This prospectus does not contain
all of the information included in the registration statement. For a more complete understanding of the offering of the securities, you
should refer to the registration statement, including its exhibits. We may add, update or change, in a prospectus supplement or free writing
prospectus, any of the information contained in this prospectus or in the documents we have incorporated by reference into this prospectus.
We may also authorize one or more free writing prospectuses to be provided to you that may contain material information relating to these
offerings. This prospectus, together with the applicable prospectus supplement, any related free writing prospectus and the documents
incorporated by reference into this prospectus and the applicable prospectus supplement, will include all material information relating
to the applicable offering. You should carefully read both this prospectus and the applicable prospectus supplement and any related free
writing prospectus, together with the additional information described under “Where You Can Find More Information,”
before buying any of the securities being offered.
We have not authorized any
dealer, agent or other person to give any information or to make any representation other than those contained or incorporated by reference
in this prospectus, any accompanying prospectus supplement or any related free writing prospectus that we may authorize to be provided
to you. You must not rely upon any information or representation not contained or incorporated by reference in this prospectus or an accompanying
prospectus supplement, or any related free writing prospectus that we may authorize to be provided to you. This prospectus, the accompanying
prospectus supplement and any related free writing prospectus, if any, do not constitute an offer to sell or the solicitation of an offer
to buy any securities other than the registered securities to which they relate, nor do this prospectus, the accompanying prospectus supplement
or any related free writing prospectus, if any, constitute an offer to sell or the solicitation of an offer to buy securities in any jurisdiction
to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction. You should not assume that the information
contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus is accurate on any date subsequent
to the date set forth on the front of the document or that any information we have incorporated by reference is correct on any date subsequent
to the date of the document incorporated by reference (as our business, financial condition, results of operations and prospects may have
changed since that date), even though this prospectus, any applicable prospectus supplement or any related free writing prospectus is
delivered or securities are sold on a later date.
We further note that the
representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated
by reference in this prospectus were made solely for the benefit of the parties to such agreement, including, in some cases, for the purpose
of allocating risk among the parties to such agreements, and should not be deemed to be a representation, warranty or covenant to you.
Moreover, such representations, warranties or covenants were accurate only as of the date when made. Accordingly, such representations,
warranties and covenants should not be relied on as accurately representing the current state of our affairs.
This prospectus may not
be used to consummate sales of our securities, unless it is accompanied by a prospectus supplement. To the extent there are inconsistencies
between any prospectus supplement, this prospectus and any documents incorporated by reference, the document with the most recent date
will control.
As permitted by the rules and
regulations of the SEC, the registration statement, of which this prospectus forms a part, includes additional information not contained
in this prospectus. You may read the registration statement and the other reports we file with the SEC at the SEC’s web site or
at the SEC’s offices described below under the heading “Where You Can Find More Information.”
Company References
In this prospectus “the
Company,” “we,” “us,” and “our” refer to Unicycive Therapeutics, Inc., a Delaware corporation,
and its subsidiaries, unless the context otherwise requires.
SUMMARY
Overview
We are a biotechnology company
dedicated to developing treatments for certain medical conditions. Currently, two of our programs are focused on kidney disease, an area
we believe we have the potential to offer medical benefit. As we grow the company and build our team, we intend to focus on identifying
medical conditions within and outside of kidney disease. Our current development programs are focused on two novel therapies: Oxylanthanum
Carbonate (“OLC”), for treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis, and UNI 494, for
treatment of acute kidney injury (“AKI”). OLC and UNI 494 were initially developed by and licensed to us from Spectrum Pharmaceuticals
(“Spectrum”) and Sphaera Pharma (“Sphaera”), respectively. Spectrum conducted a Phase 1 clinical trial with OLC
in 2012, prior to the grant of our license in 2018. Sphaera conceived and performed initial characterization of various potential pro-drug
linkers, including the initial patent application, and performed some initial physiochemical characterization and preliminary animal pharmacokinetic
studies. As discussed herein, after completing IND enabling preclinical studies, we have conducted a Phase I clinical study in healthy
volunteers with UNI 494 in 2023.
Chronic kidney disease (“CKD”)
is the gradual loss of kidney (renal) function that can get worse over time leading to lasting damage and possibly Stage 5 or end-stage
renal disease (“ESRD”). Our initial focus is on developing drugs and getting them approved in the U.S., and then to partner
with global biopharmaceutical companies in the rest of the world. According to the United States Renal Data System (“USRDS”)
2022 Annual Data Report, 30 million (14%) of adults in the United States are estimated to have CKD and, of these, approximately 13 million
patients have advanced CKD (stage 3-5). Approximately 550,000 patients (ESRD) are on dialysis and of those, approximately 450,000 patients
(~80%) take phosphate binders to control hyperphosphatemia (too much phosphorus in their blood). The number of patients with ESRD in the
U.S. is increasing steadily and is projected to reach between 971,000 and 1,259,000 patients in 2030.
AKI is a sudden episode of
kidney failure or kidney damage (within the first 90 days of injury). After 90 days, the patient is considered to have progressed into
CKD. AKI affects more than 2 million U.S. patients and costs the healthcare system in excess of $9 billion per year. More than 300,000
patients per year in the U.S. die due to AKI that has many causes.
Our
business model is to license technologies and drugs in order to pursue development, regulatory approval, and commercialization of those
products in global markets. Many biotechnology companies utilize similar strategies of in-licensing and then developing and commercializing
drugs. We believe, however, that our management team’s broad network, expertise in the biopharmaceutical industry, and successful
track record gives us an advantage in identifying and bringing these assets into our company.
Pipeline
Our proprietary pipeline is comprised of our two
product candidates – OLC and UNI 494 – which are described below.
Figure 1 Unicycive Product Pipeline
Recent Developments
New Drug Application
On
September 3, 2024, we submitted a New Drug Application (“NDA”) to the U.S. Food and Drug Administration (“FDA”)
for OLC for the treatment of hyperphosphatemia in patients with CKD on dialysis. On November 11, 2024, we announced that the FDA has accepted
the NDA for OLC and has set a Prescription Drug User Fee Act (PDUFA) target action date of June 28, 2025.
Company Information
We were incorporated as a
Delaware corporation on August 18, 2016. Our principal executive offices are located at 5150 El Camino Real, Suite A-32, Los Altos, CA
94022 and our telephone number is (650) 351-4495. Our website address is http://www.unicycive.com. The information contained
on our website is not incorporated by reference into this prospectus, and you should not consider any information contained on, or that
can be accessed through, our website as part of this prospectus or in deciding whether to purchase our common stock. We have included
our website address as a factual reference and do not intend it to be an active link to our website.
The Securities We May Offer
We may offer shares of our
common stock and preferred stock, various series of debt securities and warrants to purchase any of such securities, either individually
or in units, from time to time under this prospectus, together with any applicable prospectus supplement and related free writing prospectus,
at prices and on terms to be determined by market conditions at the time of offering. If we issue any debt securities at a discount from
their original stated principal amount, then, for purposes of calculating the total dollar amount of all securities issued under this
prospectus, we will treat the initial offering price of the debt securities as the total original principal amount of the debt securities.
Each time we offer securities under this prospectus, we will provide offerees with a prospectus supplement that will describe the specific
amounts, prices and other important terms of the securities being offered, including, to the extent applicable:
| ● | designation or classification; |
| ● | aggregate principal amount or aggregate offering price; |
| ● | maturity, if applicable; |
| ● | original issue discount, if any; |
| ● | rates and times of payment of interest or dividends, if any; |
| ● | redemption, conversion, exchange or sinking fund terms, if
any; |
| ● | conversion or exchange prices or rates, if any, and, if applicable,
any provisions for changes to or adjustments in the conversion or exchange prices or rates and in the securities or other property receivable
upon conversion or exchange; |
| ● | restrictive covenants, if any; |
| ● | voting or other rights, if any; and |
| ● | important United States federal income tax considerations. |
A prospectus supplement and
any related free writing prospectus that we may authorize to be provided to you may also add, update, or change information contained
in this prospectus or in documents we have incorporated by reference. However, no prospectus supplement or free writing prospectus will
offer a security that is not registered and described in this prospectus at the time of the effectiveness of the registration statement
of which this prospectus is a part.
We may sell the securities
to or through underwriters, dealers or agents or directly to purchasers. We, as well as any agents acting on our behalf, reserve the sole
right to accept and to reject in whole or in part any proposed purchase of securities. Each prospectus supplement will set forth the names
of any underwriters, dealers or agents involved in the sale of securities described in that prospectus supplement and any applicable fee,
commission or discount arrangements with them, details regarding any over-allotment option granted to them, and net proceeds to us. The
following is a summary of the securities we may offer with this prospectus.
Common Stock
We currently have authorized
400,000,000 shares of common stock, par value $0.001 per share. As of November 13, 2024, 103,796,406 shares of common stock were issued
and outstanding. We may offer shares of our common stock either alone or underlying other registered securities convertible into or exercisable
for our common stock. Holders of our common stock are entitled to such dividends as our board of directors (the “Board of Directors”
or “Board”) may declare from time to time out of legally available funds, subject to the preferential rights of the holders
of any shares of our preferred stock that are outstanding or that we may issue in the future. Currently, we do not pay any dividends on
our common stock. Each holder of our common stock is entitled to one vote per share. In this prospectus, we provide a general description
of, among other things, the rights and restrictions that apply to holders of our common stock.
Preferred Stock
We currently have authorized
10,000,000 shares of preferred stock, par value $0.001, of which (i) (A) 21,400 shares of our preferred stock have been designated as
Series A-2 Prime Preferred Stock, (B) 25,900 have been designated as Series A-3 Preferred Stock, (C) 25,700 have been designated as Series
A-4 Preferred Stock, and (D) 51,600 have been designated as Series A-5 Preferred Stock (collectively, “Series A Preferred Stock”)
and (ii) (A) 50,000 shares of our preferred stock have been designated as Series B-1 Preferred Stock and (B) 50,000 have been designated
as Series B-2 Preferred Stock (collectively, “Series B Preferred Stock”). Our Board may establish the rights and preferences
of the preferred stock from time to time. As of November 13, 2024, there were 8,416.24 shares of Series A-2 Prime Preferred Stock issued
and outstanding, no shares of Series A-3 Preferred Stock issued and outstanding, no shares of Series A-4 Preferred Stock issued and outstanding,
no shares of Series A-5 Preferred Stock issued and outstanding; no shares of Series B-1 Preferred Stock issued and outstanding and 7,444
shares of Series B-2 Preferred Stock issued and outstanding.
Any authorized and undesignated
shares of preferred stock may be issued from time to time in one or more additional series pursuant to a resolution or resolutions providing
for such issue duly adopted by our Board of Directors (authority to do so being hereby expressly vested in the Board of Directors). The
Board of Directors is further authorized, subject to limitations prescribed by law, to fix by resolution or resolutions the designations,
powers, preferences and rights, and the qualifications, limitations or restrictions thereof, of any wholly unissued series of preferred
stock, including without limitation authority to fix by resolution or resolutions the dividend rights, dividend rate, conversion rights,
voting rights, rights and terms of redemption (including sinking fund provisions), redemption price or prices, and liquidation preferences
of any such series, and the number of shares constituting any such series and the designation thereof, or any of the foregoing.
The rights, preferences, privileges,
and restrictions granted to or imposed upon any series of preferred stock that we offer and sell under this prospectus and applicable
prospectus supplements will be set forth in a certificate of designation relating to the series. We will incorporate by reference into
the registration statement of which this prospectus is a part the form of any certificate of designation that describes the terms of the
series of preferred stock we are offering before the issuance of shares of that series of preferred stock. You should read any prospectus
supplement and any free writing prospectus that we may authorize to be provided to you related to the series of preferred stock being
offered, as well as the complete certificate of designation that contains the terms of the applicable series of preferred stock.
Debt Securities
We may offer general debt
obligations, which may be secured or unsecured, senior or subordinated, and convertible into shares of our common stock or preferred stock.
In this prospectus, we refer to the senior debt securities and the subordinated debt securities together as the “debt securities.”
We may issue debt securities under a note purchase agreement or under an indenture to be entered between us and a trustee. The indentures
do not limit the amount of securities that may be issued under it and provide that debt securities may be issued in one or more series.
The senior debt securities will have the same rank as all of our other indebtedness that is not subordinated. The subordinated debt securities
will be subordinated to our senior debt on terms set forth in the applicable prospectus supplement. In addition, the subordinated debt
securities will be effectively subordinated to creditors and preferred stockholders of our subsidiaries. Our Board of Directors will determine
the terms of each series of debt securities being offered. This prospectus contains only general terms and provisions of the debt securities.
The applicable prospectus supplement will describe the particular terms of the debt securities offered thereby. You should read any prospectus
supplement and any free writing prospectus that we may authorize to be provided to you related to the series of debt securities being
offered, as well as the complete note agreements and/or indentures that contain the terms of the debt securities. The forms of senior
and subordinated indentures have been filed as exhibits to the registration statement of which this prospectus is a part, and supplemental
indentures and forms of debt securities containing the terms of debt securities being offered will be incorporated by reference into the
registration statement of which this prospectus is a part from reports we file with the SEC.
Warrants
We may offer warrants for
the purchase of shares of our common stock or preferred stock or of debt securities. We may issue the warrants by themselves or together
with common stock, preferred stock or debt securities, and the warrants may be attached to or separate from any offered securities. Any
warrants issued under this prospectus may be evidenced by warrant certificates. Warrants may be issued under a separate warrant agreement
to be entered into between us and the investors or a warrant agent. Our Board of Directors will determine the terms of the warrants. This
prospectus contains only general terms and provisions of the warrants. The applicable prospectus supplement will describe the particular
terms of the warrants being offered thereby. You should read any prospectus supplement and any free writing prospectus that we may authorize
to be provided to you related to the series of warrants being offered, as well as the complete warrant agreements that contain the terms
of the warrants. Specific warrant agreements will contain additional important terms and provisions and will be incorporated by reference
into the registration statement of which this prospectus is a part from reports we file with the SEC.
Units
We may offer units consisting
of our common stock or preferred stock, debt securities and/or warrants to purchase any of these securities in one or more series. We
may evidence each series of units by unit certificates that we will issue under a separate agreement. We may enter into unit agreements
with a unit agent. Each unit agent will be a bank or trust company that we select. We will indicate the name and address of the unit agent
in the applicable prospectus supplement relating to a particular series of units. This prospectus contains only a summary of certain general
features of the units. The applicable prospectus supplement will describe the particular features of the units being offered thereby.
You should read any prospectus supplement and any free writing prospectus that we may authorize to be provided to you related to the series
of units being offered, as well as the complete unit agreements that contain the terms of the units. Specific unit agreements will contain
additional important terms and provisions and will be incorporated by reference into the registration statement of which this prospectus
is a part from reports we file with the SEC.
RISK FACTORS
An investment in our securities
involves a high degree of risk. This prospectus contains, and the prospectus supplement applicable to each offering of our securities
will contain, a discussion of the risks applicable to an investment in our securities. Prior to making a decision about investing in our
securities, you should carefully consider the specific factors discussed under the heading “Risk Factors” in this prospectus
and the applicable prospectus supplement, together with all of the other information contained or incorporated by reference in the prospectus
supplement or appearing or incorporated by reference in this prospectus. You should also consider the risks, uncertainties and assumptions
discussed under Item 1A, “Risk Factors,” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed
with the SEC on March 28, 2024, and any updates described in our Quarterly Reports on Form 10-Q, all of which are incorporated herein
by reference, and may be amended, supplemented or superseded from time to time by other reports we file with the SEC in the future and
any prospectus supplement related to a particular offering. The risks and uncertainties we have described are not the only ones we face.
Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also affect our operations. The
occurrence of any of these known or unknown risks might cause you to lose all or part of your investment in the offered securities.
DISCLOSURE REGARDING FORWARD-LOOKING STATEMENTS
This prospectus, any accompanying
prospectus supplement, any related free writing prospectus and the documents incorporated by reference herein or therein contain, in addition
to historical information, certain forward-looking statements within the meaning of Section 27A of the Securities Act or 1933, as amended
(the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”),
that include information relating to future events, future financial performance, strategies, expectations, competitive environment, regulation
and availability of resources. Such forward-looking statements include those that express plans, anticipation, intent, contingency, goals,
targets or future development and/or otherwise are not statements of historical fact. These forward-looking statements are based on our
current expectations and projections about future events and they are subject to risks and uncertainties known and unknown that could
cause actual results and developments to differ materially from those expressed or implied in such statements.
In some cases, you can identify
forward-looking statements by terminology, such as “expects,” “anticipates,” “intends,” “estimates,”
“plans,” “believes,” “seeks,” “may,” “should”, “could” or the
negative of such terms or other similar expressions. Accordingly, these statements involve estimates, assumptions and uncertainties that
could cause actual results to differ materially from those expressed in them. Any forward-looking statements are qualified in their entirety
by reference to the factors discussed throughout this prospectus, any accompanying prospectus supplement or incorporated herein by reference.
Risks, uncertainties and other
factors that may cause our actual results, performance or achievements to be different from those expressed or implied in our written
or oral forward-looking statements may be found in this prospectus and any accompanying prospectus supplement under the heading “Risk
Factors” and in our Annual Report on Form 10-K for the year ended December 31, 2023 under the headings “Risk Factors”
and “Business,” as updated in our Quarterly Report(s) on Form 10-Q.
Forward-looking statements
speak only as of the date they are made. You should not put undue reliance on any forward-looking statements. We assume no obligation
to update forward-looking statements to reflect actual results, changes in assumptions or changes in other factors affecting forward-looking
information, except to the extent required by applicable securities laws. If we do update one or more forward-looking statements, no inference
should be drawn that we will make additional updates with respect to those or other forward-looking statements.
New factors emerge from time
to time, and it is not possible for us to predict which factors will arise. In addition, we cannot assess the impact of each factor on
our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained
in any forward-looking statements. We qualify all of the information presented in this prospectus, any accompanying prospectus supplement
and incorporated herein by reference, and particularly our forward-looking statements, by these cautionary statements.
USE OF PROCEEDS
Except as described in any
prospectus supplement and any free writing prospectus in connection with a specific offering, we currently intend to use the net proceeds
from the sale of the securities offered under this prospectus for general corporate purposes, including the development and commercialization
of our products, research and development, general and administrative expenses, license or technology acquisitions, and working capital
and capital expenditures. We may also use the net proceeds to repay any debts and/or invest in or acquire complementary businesses, products,
or technologies, although we have no current commitments or agreements with respect to any such investments or acquisitions as of the
date of this prospectus. We have not determined the amount of net proceeds to be used specifically for the foregoing purposes. As a result,
our management will have broad discretion in the allocation of the net proceeds and investors will be relying on the judgment of our management
regarding the application of the proceeds of any sale of the securities. Pending use of the net proceeds, we intend to invest the proceeds
in short-term, investment-grade, interest-bearing instruments.
Each time we offer securities
under this prospectus, we will describe the intended use of the net proceeds from that offering in the applicable prospectus supplement.
The actual amount of net proceeds we spend on a particular use will depend on many factors, including, our future capital expenditures,
the amount of cash required by our operations, and our future revenue growth, if any. Therefore, we will retain broad discretion in the
use of the net proceeds.
DESCRIPTION OF CAPITAL STOCK
General
The following description
of our capital stock, together with any additional information we include in any applicable prospectus supplement or any related free
writing prospectus, summarizes the material terms and provisions of our common stock and the preferred stock that we may offer under this
prospectus. While the terms we have summarized below will apply generally to any future common stock or preferred stock that we may offer,
we will describe the particular terms of any class or series of these securities in more detail in the applicable prospectus supplement.
For the complete terms of our common stock and preferred stock, please refer to our amended and restated certificate of incorporation,
as amended (“Certificate of Incorporation”), and our bylaws that are incorporated by reference into the registration statement
of which this prospectus is a part or may be incorporated by reference in this prospectus or any applicable prospectus supplement. The
terms of these securities may also be affected by Delaware General Corporation Law (the “DGCL”). The summary below and that
contained in any applicable prospectus supplement or any related free writing prospectus are qualified in their entirety by reference
to our Certificate of Incorporation and our bylaws.
As of the date of this prospectus,
our authorized capital stock consisted of 400,000,000 shares of common stock, $0.001 par value per share, and 10,000,000 shares of preferred
stock, $0.001 par value per share of which (i) (A) 21,400 shares of our preferred stock have been designated as Series A-2 Prime Preferred
Stock, (B) 25,900 have been designated as Series A-3 Convertible Preferred Stock, (C) 25,700 have been designated as Series A-4 Convertible
Preferred Stock, and (D) 51,600 have been designated as Series A-5 Convertible Preferred Stock (collectively, “Series A Preferred
Stock”) and (ii) (A) 50,000 shares of our preferred stock have been designated as Series B-1 Preferred Stock and (B) 50,000 have
been designated as Series B-2 Preferred Stock (collectively, “Series B Preferred Stock”). Our Board may establish the rights
and preferences of the preferred stock from time to time. As of November 13, 2024, there were 103,796,406 shares of our common stock issued
and outstanding, 8,416.24 shares of Series A-2 Prime Preferred Stock issued and outstanding, no shares of Series A-3 Convertible Preferred
Stock issued and outstanding, no shares of Series A-4 Convertible Preferred Stock issued and outstanding, no shares of Series A-5 Convertible
Preferred Stock issued and outstanding; no shares of Series B-1 Preferred Stock issued and outstanding and 7,444 shares of Series B-2
Preferred Stock issued and outstanding.
Common Stock
We are authorized to issue
up to a total of 400,000,000 shares of common stock, par value $0.001 per share. Holders of our common stock are entitled to one vote
for each share held on all matters submitted to a vote of our stockholders. Holders of our common stock have no cumulative voting rights.
All shares of common stock offered hereby will, when issued, be fully paid and nonassessable, including shares of common stock issued
upon the exercise of common stock warrants or subscription rights, if any. Holders of our common stock are entitled, subject to the rights,
privileges, restrictions and conditions attaching to any other class of shares ranking in priority to the common stock, to receive any
dividend declared by our board of directors.
Further, holders of our common
stock have no preemptive or conversion rights or other subscription rights. Upon our liquidation, dissolution or winding- up, holders
of our common stock are entitled to share in all assets remaining after payment of all liabilities and the liquidation preferences of
any of our outstanding shares of preferred stock. Subject to preferences that may be applicable to any outstanding shares of preferred
stock, holders of our common stock are entitled to receive dividends, if any, as may be declared from time to time by our Board of Directors
out of our assets which are legally available. Such dividends, if any, are payable in cash, in property or in shares of capital stock.
The holders of a majority
of the shares of our capital stock, represented in person or by proxy, are necessary to constitute a quorum for the transaction of business
at any meeting. If a quorum is present, an action by stockholders entitled to vote on a matter is approved if the number of votes cast
in favor of the action exceeds the number of votes cast in opposition to the action, with the exception of the election of directors,
which requires a plurality of the votes cast.
Preferred Stock
Our Board of Directors has
the authority, without further action by the stockholders, to issue up to 10,000,000 shares of preferred stock in one or more series and
to fix the designations, powers, preferences, privileges, and relative participating, optional, or special rights as well as the qualifications,
limitations, or restrictions of the preferred stock, including dividend rights, conversion rights, voting rights, terms of redemption,
and liquidation preferences, any or all of which may be greater than the rights of the common stock. Our Board of Directors, without stockholder
approval, can issue preferred stock with voting, conversion, or other rights that could adversely affect the voting power and other rights
of the holders of common stock. Preferred stock could be issued quickly with terms calculated to delay or prevent a change of control
or make removal of management more difficult. Additionally, the issuance of preferred stock may have the effect of decreasing the market
price of our common stock, and may adversely affect the voting and other rights of the holders of common stock. At present, we have no
plans to issue any shares of preferred stock following this offering.
Series A Preferred Stock
Dividends. At
all times following the Issuance Date, while shares of Series A Preferred Stock are issued and outstanding, holders of Series A Preferred
Stock shall be entitled to receive, and the Company shall pay, dividends on shares of Series A Preferred Stock equal (on an as-if-converted-to-Common-Stock
basis and without regard to any limitations on conversion set forth herein or otherwise) to and in the same form as dividends (other than
dividends in the form of common stock, which shall be made in accordance with the terms of the Amended Certificate of Designation) actually
paid on shares of the common stock when, as and if such dividends (other than dividends in the form of common stock, which shall be made
in accordance with the terms of the Amended and Restated Certificate of Designation of Preferences, Rights And Limitations of Series A
Convertible Voting Preferred Stock (the “Amended Series A Certificate Designation”) are paid on shares of the common stock.
Voting
Rights. Subject to certain limitations described in the Amended Series A Certificate of Designation, the Series A Preferred
Stock is voting stock. Holders of the Series A Preferred Stock are entitled to vote together with the common stock on an as-if-converted-to-Common-Stock
basis. Holders of common stock are entitled to one vote for each share of common stock held on all matters submitted to a vote of stockholders.
Accordingly, holders of Series A Preferred Stock will be entitled to one vote for each whole share of common stock into which their Series
A Preferred Stock is then-convertible on all matters submitted to a vote of stockholders.
Liquidation.
Upon any Liquidation, the assets of the Company available for distribution to its stockholders shall be distributed among the holders
of the shares of Series A Preferred Stock and common stock, pro rata based on the number of shares held by each such holder, treating
for this purpose all shares of Series A Preferred Stock as if they had been converted to common stock pursuant to the terms of the Amended
Series A Certificate of Designation immediately prior to such Liquidation, without regard to any limitations on conversion set forth in
the Amended Series A Certificate of Designation or otherwise.
Conversion. Subject
to the limitations set forth in the Amended Series A Certificate of Designation, at the option of the holder, each share of Series A-2
Prime Preferred Stock, Series A-3 Convertible Preferred Stock, Series A-4 Convertible Preferred Stock or Series A-5 Convertible Preferred
Stock shall be convertible into a number shares of common stock obtained by dividing the Original Per Share Price ($1,000) of each such
share of Series A-2 Prime Preferred Stock, Series A-3 Convertible Preferred Stock, Series A-4 Convertible Preferred Stock or Series A-5
Convertible Preferred Stock by the applicable conversion price of $0.49, $0.54, $0.59 and $0.74 for the Series A-2 Prime Preferred Stock,
Series A-3 Convertible Preferred Stock, Series A-4 Convertible Preferred Stock or Series A-5 Convertible Preferred Stock, respectively.
The
foregoing summary of the terms of the Series A Preferred Stock is qualified in its entirety by reference to the text of the Amended
Series Certificate of Designation, which is filed hereto as Exhibit 3.3 and is incorporated herein by reference.
Series
B Preferred Stock
All
shares of Series B-1 Preferred Stock were converted into our common stock and/or Series B-2 Preferred Stock on July 5, 2024 following
stockholder approval on June 20, 2024. The terms of the Series B-2 Preferred Stock are as follows:
Stated
Value: The Series B Preferred Stock has a Stated Value of $1,000 per share.
Dividends. At
all times following the Issuance Date, while shares of Series B-2 Preferred Stock are issued and outstanding, holders of Series B Preferred
Stock shall be entitled to receive, and the Company shall pay, dividends on shares of Series B-2 Preferred Stock equal (on an as-if-converted-to-Common-Stock
basis and without regard to any limitations on conversion set forth herein or otherwise) to and in the same form as dividends (other than
dividends in the form of common stock, which shall be made in accordance with the terms of the Series B Certificate of Designation) actually
paid on shares of the common stock when, as and if such dividends (other than dividends in the form of common stock, which shall be made
in accordance with the terms of the Certificate of Designation of Preferences, Rights And Limitations of Series B Convertible Preferred
Stock (the “Series B Certificate of Designation”) are paid on shares of the common stock.
Voting
Rights. Subject to certain limitations described in the Series B Certificate of Designation, the Series B-2 Preferred Stock
is voting stock. Holders of the Series B-2 Preferred Stock are entitled to vote together with the common stock on an as-if-converted-to-Common-Stock
basis. Holders of common stock are entitled to one vote for each share of common stock held on all matters submitted to a vote of stockholders.
Accordingly, holders of Series B-2 Preferred Stock will be entitled to one vote for each whole share of common stock into which their
Series B-2 Preferred Stock is then-convertible on all matters submitted to a vote of stockholders.
Liquidation.
Upon any Liquidation, the assets of the Company available for distribution to its stockholders shall be distributed among the holders
of the shares of Series B-2 Preferred Stock and common stock, pro rata based on the number of shares held by each such holder, treating
for this purpose all shares of Series B-2 Preferred Stock as if they had been converted to common stock pursuant to the terms of the Certificate
of Designation immediately prior to such Liquidation, without regard to any limitations on conversion set forth in the Series B Certificate
of Designation or otherwise.
Conversion.
Subject to the limitations set forth in the Series B-2 Certificate of Designation,
at the option of the holder, each share of Series B-2 Preferred Stock shall be convertible is convertible into the number of shares of
common stock equal to the quotient of (A) the stated value ($1,000), divided by (B) the conversion price on the applicable conversion
date, which is $1.00 as of the date of this registration statement.
The
foregoing summary of the terms of the Series B-2 Preferred Stock is qualified in its entirety by reference to the text of the Series B
Certificate of Designation, which is filed hereto as Exhibit 3.4 and is incorporated herein by reference.
Warrants
As of November 13, 2024, there
were outstanding warrants to purchase an aggregate of (i) 4,784,193 shares of our common stock at a weighted average exercise price of
$6.00 per share; (ii) 25,840.3122 shares of our Series A-3 Convertible Preferred Stock at an exercise price of $1,000 per share, which
shares Series A-3 Convertible Preferred Stock are convertible into 47,852,430 shares of our common stock; (iii) 25,666,30154 shares of
our Series A-4 Convertible Preferred Stock at an exercise price of $1,000 per share, which shares of Series A-4 Convertible Preferred
Stock are convertible into 43,502,206 shares of our common stock; and (iv) 51,506.61294 shares of our Series A-5 Convertible Preferred
Stock at an exercise price of $1,000 per share, which shares of Series A-5 Convertible Preferred Stock are convertible into 69,603,531
shares of our common stock
Anti-Takeover Effects of Certain Provisions
of our Certificate of Incorporation, Bylaws and the DGCL
We are governed by the provisions
of Section 203 of the DGCL. In general, Section 203 prohibits a publicly traded Delaware corporation from engaging in a business combination
with an interested stockholder for a period of three years after the date of the transaction in which the person became an interested
stockholder, unless the business combination is approved in a prescribed manner. A business combination includes mergers, asset sales
or other transactions resulting in a financial benefit to the stockholder. An interested stockholder is a person who, together with affiliates
and associates, owns (or within three years, did own) 15% or more of the corporation’s voting stock, subject to certain exceptions.
The statute could have the effect of delaying, deferring or preventing a change in control of our Company.
Our Certificate of Incorporation
and bylaws contain provisions that could have the effect of discouraging potential acquisition proposals or making a tender offer or delaying
or preventing a change in control, including changes a stockholder might consider favorable. In particular, our Certificate of Incorporation
and bylaws, as applicable, among other things:
| ● | provide our Board of Directors with the ability to alter our
bylaws without stockholder approval; and |
| ● | provide that vacancies on our Board of Directors may be filled
by a majority of directors in office, although less than a quorum. |
Such provisions may have the
effect of discouraging a third party from acquiring us, even if doing so would be beneficial to our stockholders. These provisions are
intended to enhance the likelihood of continuity and stability in the composition of our Board of Directors and in the policies formulated
by them, and to discourage some types of transactions that may involve an actual or threatened change in control of our Company. These
provisions are designed to reduce our vulnerability to an unsolicited acquisition proposal and to discourage some tactics that may be
used in proxy fights. We believe that the benefits of increased protection of our potential ability to negotiate with the proponent of
an unfriendly or unsolicited proposal to acquire or restructure our Company outweigh the disadvantages of discouraging such proposals
because, among other things, negotiation of such proposals could result in an improvement of their terms.
However, these provisions
could have the effect of discouraging others from making tender offers for our shares that could result from actual or rumored takeover
attempts. These provisions also may have the effect of preventing changes in our management.
Listing
Our common stock is listed
on The Nasdaq Capital Market under the trading symbol “UNCY.”
Transfer Agent and Registrar
The Transfer Agent and Registrar
for our common stock is Pacific Stock Transfer Company.
DESCRIPTION OF DEBT SECURITIES
The following description,
together with the additional information we include in any applicable prospectus supplements or free writing prospectuses, summarizes
the material terms and provisions of the debt securities that we may offer under this prospectus. We may issue debt securities, in one
or more series, as either senior or subordinated debt or as senior or subordinated convertible debt. While the terms we have summarized
below will apply generally to any future debt securities we may offer under this prospectus, we will describe the particular terms of
any debt securities that we may offer in more detail in the applicable prospectus supplement or free writing prospectus. The terms of
any debt securities we offer under a prospectus supplement may differ from the terms we describe below. However, no prospectus supplement
shall fundamentally change the terms that are set forth in this prospectus or offer a security that is not registered and described in
this prospectus at the time of its effectiveness. As of the date of this prospectus, we have no outstanding registered debt securities.
Unless the context requires otherwise, whenever we refer to the “indentures,” we also are referring to any supplemental indentures
that specify the terms of a particular series of debt securities.
We will issue any senior debt
securities under the senior indenture that we will enter into with the trustee named in the senior indenture. We will issue any subordinated
debt securities under the subordinated indenture and any supplemental indentures that we will enter into with the trustee named in the
subordinated indenture. We have filed forms of these documents as exhibits to the registration statement, of which this prospectus is
a part, and supplemental indentures and forms of debt securities containing the terms of the debt securities being offered will be filed
as exhibits to the registration statement of which this prospectus is a part or will be incorporated by reference from reports that we
file with the SEC.
The indentures will be qualified
under the Trust Indenture Act of 1939, as amended (the “Trust Indenture Act”). We use the term “trustee” to refer
to either the trustee under the senior indenture or the trustee under the subordinated indenture, as applicable.
The following summaries of
material provisions of the senior debt securities, the subordinated debt securities and the indentures are subject to, and qualified in
their entirety by reference to, all of the provisions of the indenture and any supplemental indentures applicable to a particular series
of debt securities. We urge you to read the applicable prospectus supplements and any related free writing prospectuses related to the
debt securities that we may offer under this prospectus, as well as the complete indentures that contains the terms of the debt securities.
Except as we may otherwise indicate, the terms of the senior indenture and the subordinated indenture are identical.
General
The terms of each series of
debt securities will be established by or pursuant to a resolution of our Board of Directors and set forth or determined in the manner
provided in an officers’ certificate or by a supplemental indenture. Debt securities may be issued in separate series without limitation
as to aggregate principal amount. We may specify a maximum aggregate principal amount for the debt securities of any series. We will describe
in the applicable prospectus supplement the terms of the series of debt securities being offered, including:
| ● | the principal amount being offered, and if a series, the total
amount authorized and the total amount outstanding; |
| ● | any limit on the amount that may be issued; |
| ● | whether or not we will issue the series of debt securities
in global form, and, if so, the terms and who the depositary will be; |
| ● | whether and under what circumstances, if any, we will pay
additional amounts on any debt securities held by a person who is not a United States person for tax purposes, and whether we can redeem
the debt securities if we have to pay such additional amounts; |
| ● | the annual interest rate, which may be fixed or variable,
or the method for determining the rate and the date interest will begin to accrue, the dates interest will be payable and the regular
record dates for interest payment dates or the method for determining such dates; |
| ● | whether or not the debt securities will be secured or unsecured,
and the terms of any secured debt; |
| ● | the terms of the subordination of any series of subordinated
debt; |
| ● | the place where payments will be made; |
| ● | restrictions on transfer, sale or other assignment, if any; |
| ● | our right, if any, to defer payment of interest and the maximum
length of any such deferral period; |
| ● | the date, if any, after which, and the price at which, we
may, at our option, redeem the series of debt securities pursuant to any optional or provisional redemption provisions and the terms
of those redemption provisions; |
| ● | provisions for a sinking fund purchase or other analogous
fund, if any, including the date, if any, on which, and the price at which we are obligated, pursuant thereto or otherwise, to redeem,
or at the holder’s option, to purchase, the series of debt securities and the currency or currency unit in which the debt securities
are payable; |
| ● | whether the indenture will restrict our ability or the ability
of our subsidiaries, if any, to: |
| ● | incur additional indebtedness; |
| ● | issue additional securities; |
| ● | pay dividends or make distributions in respect of our capital
stock or the capital stock of our subsidiaries; |
| ● | place restrictions on our subsidiaries’ ability to
pay dividends, make distributions or transfer assets; |
| ● | make investments or other restricted payments; |
| ● | sell or otherwise dispose of assets; |
| ● | enter into sale-leaseback transactions; |
| ● | engage in transactions with stockholders or affiliates; |
| ● | issue or sell stock of our subsidiaries; or |
| ● | effect a consolidation or merger; |
| ● | whether the indenture will require us to maintain any interest
coverage, fixed charge, cash flow-based, asset-based or other financial ratios; |
| ● | a discussion of certain material or special United States
federal income tax considerations applicable to the debt securities; |
| ● | information describing any book-entry features; |
| ● | the applicability of the provisions in the indenture on discharge; |
| ● | whether the debt securities are to be offered at a price such
that they will be deemed to be offered at an “original issue discount” as defined in paragraph (a) of Section 1273
of the Internal Revenue Code of 1986, as amended; |
| ● | the denominations in which we will issue the series of debt
securities, if other than denominations of $1,000 and any integral multiple thereof; |
| ● | the currency of payment of debt securities if other than U.S.
dollars and the manner of determining the equivalent amount in U.S. dollars; and |
| ● | any other specific terms, preferences, rights or limitations
of, or restrictions on, the debt securities, including any additional events of default or covenants provided with respect to the debt
securities, and any terms that may be required by us or advisable under applicable laws or regulations. |
Conversion or Exchange Rights
We will set forth in the applicable
prospectus supplement the terms under which a series of debt securities may be convertible into or exchangeable for our common stock,
our preferred stock or other securities (including securities of a third party). We will include provisions as to whether conversion or
exchange is mandatory, at the option of the holder or at our option. We may include provisions pursuant to which the number of shares
of our common stock, our preferred stock or other securities (including securities of a third party) that the holders of the series of
debt securities receive would be subject to adjustment.
Consolidation, Merger or Sale
Unless we provide
otherwise in the prospectus supplement applicable to a particular series of debt securities, the indentures will not contain any
covenant that restricts our ability to merge or consolidate, or sell, convey, transfer or otherwise dispose of all or substantially
all of our assets. However, any successor to or acquirer of such assets must assume all of our obligations under the indentures or
the debt securities, as appropriate. If the debt securities are convertible into or exchangeable for our other securities or
securities of other entities, the person with whom we consolidate or merge or to whom we sell all of our property must make
provisions for the conversion of the debt securities into securities that the holders of the debt securities would have received if
they had converted the debt securities before the consolidation, merger or sale.
Events of Default under the Indenture
Unless we provide otherwise
in the prospectus supplement applicable to a particular series of debt securities, the following are events of default under the indentures
with respect to any series of debt securities that we may issue:
| ● | if we fail to pay interest when due and payable and our failure
continues for 90 days and the time for payment has not been extended; |
| ● | if we fail to pay the principal, premium or sinking fund payment,
if any, when due and payable at maturity, upon redemption or repurchase or otherwise, and the time for payment has not been extended; |
| ● | if we fail to observe or perform any other covenant contained
in the debt securities or the indentures, other than a covenant specifically relating to another series of debt securities, and our failure
continues for 90 days after we receive notice from the trustee or we and the trustee receive notice from the holders of at least 25%
in aggregate principal amount of the outstanding debt securities of the applicable series; and |
| ● | if specified events of bankruptcy, insolvency or reorganization
occur. |
We will describe in each applicable
prospectus supplement any additional events of default relating to the relevant series of debt securities.
If an event of default with
respect to debt securities of any series occurs and is continuing, other than an event of default specified in the last bullet point above,
the trustee or the holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series, by notice
to us in writing, and to the trustee if notice is given by such holders, may declare the unpaid principal, premium, if any, and accrued
interest, if any, due and payable immediately. If an event of default arises due to the occurrence of certain specified bankruptcy, insolvency
or reorganization events, the unpaid principal, premium, if any, and accrued interest, if any, of each issue of debt securities then outstanding
shall be due and payable without any notice or other action on the part of the trustee or any holder.
The holders of a majority
in principal amount of the outstanding debt securities of an affected series may waive any default or event of default with respect to
the series and its consequences, except defaults or events of default regarding payment of principal, premium, if any, or interest, unless
we have cured the default or event of default in accordance with the indenture. Any waiver shall cure the default or event of default.
Subject to the terms of the
indentures, if an event of default under an indenture shall occur and be continuing, the trustee will be under no obligation to exercise
any of its rights or powers under such indenture at the request or direction of any of the holders of the applicable series of debt securities,
unless such holders have offered the trustee reasonable indemnity or security satisfactory to it against any loss, liability or expense.
The holders of a majority in principal amount of the outstanding debt securities of any series will have the right to direct the time,
method and place of conducting any proceeding for any remedy available to the trustee, or exercising any trust or power conferred on the
trustee, with respect to the debt securities of that series, provided that:
| ● | the direction so given by the holder is not in conflict with
any law or the applicable indenture; and |
| ● | subject to its duties under the Trust Indenture Act, the trustee
need not take any action that might involve it in personal liability or might be unduly prejudicial to the holders not involved in the
proceeding. |
The indentures will provide
that if an event of default has occurred and is continuing, the trustee will be required in the exercise of its powers to use the degree
of care that a prudent person would use in the conduct of its own affairs. The trustee, however, may refuse to follow any direction that
conflicts with law or the indenture, or that the trustee determines is unduly prejudicial to the rights of any other holder of the relevant
series of debt securities, or that would involve the trustee in personal liability. Prior to taking any action under the indentures, the
trustee will be entitled to indemnification against all costs, expenses and liabilities that would be incurred by taking or not taking
such action.
A holder of the debt securities
of any series will have the right to institute a proceeding under the indentures or to appoint a receiver or trustee, or to seek other
remedies only if:
| ● | the holder has given written notice to the trustee of a continuing
event of default with respect to that series; |
| ● | the holders of at least 25% in aggregate principal amount
of the outstanding debt securities of that series have made a written request and such holders have offered reasonable indemnity to the
trustee or security satisfactory to it against any loss, liability or expense or to be incurred in compliance with instituting the proceeding
as trustee; and |
| ● | the trustee does not institute the proceeding, and does not
receive from the holders of a majority in aggregate principal amount of the outstanding debt securities of that series other conflicting
directions within 90 days after the notice, request and offer. |
These limitations do not apply
to a suit instituted by a holder of debt securities if we default in the payment of the principal, premium, if any, or interest on, the
debt securities, or other defaults that may be specified in the applicable prospectus supplement.
We will periodically file
statements with the trustee regarding our compliance with specified covenants in the indentures.
The indentures will provide
that if a default occurs and is continuing and is actually known to a responsible officer of the trustee, the trustee must mail to each
holder notice of the default within the earlier of 90 days after it occurs and 30 days after it is known by a responsible officer of the
trustee or written notice of it is received by the trustee, unless such default has been cured or waived. Except in the case of a default
in the payment of principal or premium of, or interest on, any debt security or certain other defaults specified in an indenture, the
trustee shall be protected in withholding such notice if and so long as the Board of Directors, the executive committee or a trust committee
of directors, or responsible officers of the trustee, in good faith determine that withholding notice is in the best interests of holders
of the relevant series of debt securities.
Modification of Indenture; Waiver
Subject to the terms of the
indenture for any series of debt securities that we may issue, we and the trustee may change an indenture without the consent of any holders
with respect to the following specific matters:
| ● | to fix any ambiguity, defect or inconsistency in the indenture; |
| ● | to comply with the provisions described above under “Description
of Debt Securities — Consolidation, Merger or Sale;” |
| ● | to comply with any requirements of the SEC in connection with
the qualification of any indenture under the Trust Indenture Act; |
| ● | to add to, delete from or revise the conditions, limitations
and restrictions on the authorized amount, terms or purposes of issue, authentication and delivery of debt securities, as set forth in
the indenture; |
| ● | to provide for the issuance of, and establish the form and
terms and conditions of, the debt securities of any series as provided under “Description of Debt Securities — General,”
to establish the form of any certifications required to be furnished pursuant to the terms of the indenture or any series of debt securities,
or to add to the rights of the holders of any series of debt securities; |
| ● | to evidence and provide for the acceptance of appointment
hereunder by a successor trustee; |
| ● | to provide for uncertificated debt securities and to make
all appropriate changes for such purpose; |
| ● | to add such new covenants, restrictions, conditions or provisions
for the benefit of the holders, to make the occurrence, or the occurrence and the continuance, of a default in any such additional covenants,
restrictions, conditions or provisions an event of default or to surrender any right or power conferred to us in the indenture; or |
| ● | to change anything that does not adversely affect the interests
of any holder of debt securities of any series in any material respect. |
In addition, under the indentures,
the rights of holders of a series of debt securities may be changed by us and the trustee with the written consent of the holders of at
least a majority in aggregate principal amount of the outstanding debt securities of each series that is affected. However, subject to
the terms of the indenture for any series of debt securities that we may issue or otherwise provided in the prospectus supplement applicable
to a particular series of debt securities, we and the trustee may only make the following changes with the consent of each holder of any
outstanding debt securities affected:
| ● | extending the stated maturity of the series of debt securities; |
| ● | reducing the principal amount, reducing the rate of or extending
the time of payment of interest, or reducing any premium payable upon the redemption or repurchase of any debt securities; or |
| ● | reducing the percentage of debt securities, the holders of
which are required to consent to any amendment, supplement, modification or waiver. |
Discharge
Each indenture provides that,
subject to the terms of the indenture and any limitation otherwise provided in the prospectus supplement applicable to a particular series
of debt securities, we may elect to be discharged from our obligations with respect to one or more series of debt securities, except for
specified obligations, including obligations to:
| ● | register the transfer or exchange of debt securities of the
series; |
| ● | replace stolen, lost or mutilated debt securities of the series; |
| ● | maintain paying agencies; |
| ● | hold monies for payment in trust; |
| ● | recover excess money held by the trustee; |
| ● | compensate and indemnify the trustee; and |
| ● | appoint any successor trustee. |
In order to exercise our rights
to be discharged, we will deposit with the trustee money or government obligations sufficient to pay all the principal of, and any premium
and interest on, the debt securities of the series on the dates payments are due.
Form, Exchange and Transfer
We will issue the debt securities
of each series only in fully registered form without coupons and, unless we otherwise specify in the applicable prospectus supplement,
in denominations of $1,000 and any integral multiple thereof. The indentures will provide that we may issue debt securities of a series
in temporary or permanent global form and as book-entry securities that will be deposited with, or on behalf of, The Depository Trust
Company or another depositary named by us and identified in a prospectus supplement with respect to that series. See “Legal Ownership
of Securities” below for a further description of the terms relating to any book-entry securities.
At the option of the holder,
subject to the terms of the indentures and the limitations applicable to global securities described in the applicable prospectus supplement,
the holder of the debt securities of any series can exchange the debt securities for other debt securities of the same series, in any
authorized denomination and of like tenor and aggregate principal amount.
Subject to the terms of the
indentures and the limitations applicable to global securities set forth in the applicable prospectus supplement, holders of the debt
securities may present the debt securities for exchange or for registration of transfer, duly endorsed or with the form of transfer endorsed
thereon duly executed if so required by us or the security registrar, at the office of the security registrar or at the office of any
transfer agent designated by us for this purpose. Unless otherwise provided in the debt securities that the holder presents for transfer
or exchange, we will make no service charge for any registration of transfer or exchange, but we may require payment of any taxes or other
governmental charges.
We will name in the applicable
prospectus supplement the security registrar, and any transfer agent in addition to the security registrar, that we initially designate
for any debt securities. We may at any time designate additional transfer agents or rescind the designation of any transfer agent or approve
a change in the office through which any transfer agent acts, except that we will be required to maintain a transfer agent in each place
of payment for the debt securities of each series.
If we elect to redeem the
debt securities of any series, we will not be required to:
| ● | issue, register the transfer of, or exchange any debt securities
of that series during a period beginning at the opening of business 15 days before the day of mailing of a notice of redemption of any
debt securities that may be selected for redemption and ending at the close of business on the day of the mailing; or |
| ● | register the transfer of or exchange any debt securities so
selected for redemption, in whole or in part, except the unredeemed portion of any debt securities we are redeeming in part. |
Information Concerning the Trustee
The trustee, other than during
the occurrence and continuance of an event of default under an indenture, undertakes to perform only those duties as are specifically
set forth in the applicable indenture and is under no obligation to exercise any of the powers given it by the indentures at the request
of any holder of debt securities unless it is offered reasonable security and indemnity against the costs, expenses and liabilities that
it might incur. However, upon an event of default under an indenture, the trustee must use the same degree of care as a prudent person
would exercise or use in the conduct of his or her own affairs.
Payment and Paying Agents
Unless we otherwise indicate
in the applicable prospectus supplement, we will make payment of the interest on any debt securities on any interest payment date to the
person in whose name the debt securities, or one or more predecessor securities, are registered at the close of business on the regular
record date for the interest payment.
We will pay principal of and
any premium and interest on the debt securities of a particular series at the office of the paying agents designated by us, except that
unless we otherwise indicate in the applicable prospectus supplement, we will make interest payments by check that we will mail to the
holder or by wire transfer to certain holders. Unless we otherwise indicate in the applicable prospectus supplement, we will designate
the corporate trust office of the trustee as our sole paying agent for payments with respect to debt securities of each series. We will
name in the applicable prospectus supplement any other paying agents that we initially designate for the debt securities of a particular
series. We will maintain a paying agent in each place of payment for the debt securities of a particular series.
All money we pay to a paying
agent or the trustee for the payment of the principal of or any premium or interest on any debt securities that remains unclaimed at the
end of two years after such principal, premium or interest has become due and payable will be repaid to us, and the holder of the debt
security thereafter may look only to us for payment thereof.
Governing Law
The indentures and the debt
securities will be governed by and construed in accordance with the laws of the State of New York, except to the extent that the Trust
Indenture Act is applicable.
Ranking Debt Securities
The subordinated debt securities
will be unsecured and will be subordinate and junior in priority of payment to certain other indebtedness to the extent described in a
prospectus supplement. The subordinated indenture does not limit the amount of subordinated debt securities that we may issue. It also
does not limit us from issuing any other secured or unsecured debt.
The senior debt securities
will be unsecured and will rank equally in right of payment to all our other senior unsecured debt. The senior indenture does not limit
the amount of senior debt securities that we may issue. It also does not limit us from issuing any other secured or unsecured debt.
DESCRIPTION OF WARRANTS
The following description,
together with the additional information we may include in any applicable prospectus supplements and free writing prospectuses, summarizes
the material terms and provisions of the warrants that we may offer under this prospectus, which may consist of warrants to purchase common
stock, preferred stock or debt securities and may be issued in one or more series. Warrants may be offered independently or together with
common stock, preferred stock or debt securities offered by any prospectus supplement, and may be attached to or separate from those securities.
While the terms we have summarized below will apply generally to any warrants that we may offer under this prospectus, we will describe
the particular terms of any series of warrants that we may offer in more detail in the applicable prospectus supplement and any applicable
free writing prospectus. The terms of any warrants offered under a prospectus supplement may differ from the terms described below. However,
no prospectus supplement will fundamentally change the terms that are set forth in this prospectus or offer a security that is not registered
and described in this prospectus at the time of its effectiveness.
We may issue the warrants
under a warrant agreement that we will enter into with a warrant agent to be selected by us. If selected, the warrant agent will act solely
as an agent of ours in connection with the warrants and will not act as an agent for the holders or beneficial owners of the warrants.
If applicable, we will file as exhibits to the registration statement of which this prospectus is a part, or will incorporate by reference
from a Current Report on Form 8-K that we file with the SEC, the form of warrant agreement, including a form of warrant certificate,
that describes the terms of the particular series of warrants we are offering before the issuance of the related series of warrants. The
following summaries of material provisions of the warrants and the warrant agreements are subject to, and qualified in their entirety
by reference to, all the provisions of the warrant agreement and warrant certificate applicable to a particular series of warrants. We
urge you to read the applicable prospectus supplement and any applicable free writing prospectus related to the particular series of warrants
that we sell under this prospectus, as well as the complete warrant agreements and warrant certificates that contain the terms of the
warrants.
General
We will describe in the applicable
prospectus supplement the terms relating to a series of warrants, including:
| ● | the offering price and aggregate number of warrants offered; |
| ● | the currency for which the warrants may be purchased; |
| ● | if applicable, the designation and terms of the securities
with which the warrants are issued and the number of warrants issued with each such security or each principal amount of such security; |
| ● | if applicable, the date on and after which the warrants and
the related securities will be separately transferable; |
| ● | in the case of warrants to purchase debt securities, the principal
amount of debt securities purchasable upon exercise of one warrant and the price at, and currency in which, this principal amount of
debt securities may be purchased upon such exercise; |
| ● | in the case of warrants to purchase common stock or preferred
stock, the number of shares of common stock or preferred stock, as the case may be, purchasable upon the exercise of one warrant and
the price at which these shares may be purchased upon such exercise; |
| ● | the effect of any merger, consolidation, sale or other disposition
of our business on the warrant agreements and the warrants; |
| ● | the terms of any rights to redeem or call the warrants; |
| ● | any provisions for changes to or adjustments in the exercise
price or number of securities issuable upon exercise of the warrants; |
| ● | the dates on which the right to exercise the warrants will
commence and expire; |
| ● | the manner in which the warrant agreements and warrants may
be modified; |
| ● | United States federal income tax consequences of holding or
exercising the warrants; |
| ● | the terms of the securities issuable upon exercise of the
warrants; and |
| ● | any other specific terms, preferences, rights or limitations
of or restrictions on the warrants. |
Before exercising their warrants, holders of warrants
will not have any of the rights of holders of the securities purchasable upon such exercise, including:
| ● | in the case of warrants to purchase debt securities, the right
to receive payments of principal of, or premium, if any, or interest on, the debt securities purchasable upon exercise or to enforce
covenants in the applicable indenture; or |
| ● | in the case of warrants to purchase common stock or preferred
stock, the right to receive dividends, if any, or, payments upon our liquidation, dissolution or winding up or to exercise voting rights,
if any. |
Exercise of Warrants
Each warrant will entitle
the holder to purchase the securities that we specify in the applicable prospectus supplement at the exercise price that we describe in
the applicable prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement, holders of the warrants may
exercise the warrants at any time up to the specified time on the expiration date that we set forth in the applicable prospectus supplement.
After the close of business on the expiration date, unexercised warrants will become void.
Holders of the warrants may
exercise the warrants by delivering the warrant certificate representing the warrants to be exercised together with specified information,
and paying the required amount to the warrant agent in immediately available funds, as provided in the applicable prospectus supplement.
We will set forth on the reverse side of the warrant certificate and in the applicable prospectus supplement the information that the
holder of the warrant will be required to deliver to us or the warrant agent as applicable.
Upon receipt of the required
payment and the warrant certificate properly completed and duly executed at the corporate trust office of the warrant agent or any other
office indicated in the applicable prospectus supplement, we will issue and deliver the securities purchasable upon such exercise. If
fewer than all of the warrants represented by the warrant certificate are exercised, then we will issue a new warrant certificate for
the remaining amount of warrants. If we so indicate in the applicable prospectus supplement, holders of the warrants may surrender securities
as all or part of the exercise price for warrants.
Enforceability of Rights by Holders of Warrants
If selected, each warrant
agent will act solely as our agent under the applicable warrant agreement and will not assume any obligation or relationship of agency
or trust with any holder of any warrant. A single bank or trust company may act as warrant agent for more than one issue of warrants.
A warrant agent will have no duty or responsibility in case of any default by us under the applicable warrant agreement or warrant, including
any duty or responsibility to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a warrant may,
without the consent of the related warrant agent or the holder of any other warrant, enforce by appropriate legal action its right to
exercise, and receive the securities purchasable upon exercise of, its warrants.
DESCRIPTION OF UNITS
The following description,
together with the additional information we may include in any applicable prospectus supplements and free writing prospectuses, summarizes
the material terms and provisions of the units that we may offer under this prospectus.
While the terms we have summarized
below will apply generally to any units that we may offer under this prospectus, we will describe the particular terms of any series of
units in more detail in the applicable prospectus supplement. The terms of any units offered under a prospectus supplement may differ
from the terms described below. However, no prospectus supplement will fundamentally change the terms that are set forth in this prospectus
or offer a security that is not registered and described in this prospectus at the time of its effectiveness.
We will file as exhibits to
the registration statement of which this prospectus is a part, or will incorporate by reference from a Current Report on Form 8-K
that we file with the SEC, the form of unit agreement that describes the terms of the series of units we are offering, and any supplemental
agreements, before the issuance of the related series of units. The following summaries of material terms and provisions of the units
are subject to, and qualified in their entirety by reference to, all the provisions of the unit agreement and any supplemental agreements
applicable to a particular series of units. We urge you to read the applicable prospectus supplements related to the particular series
of units that we sell under this prospectus, as well as the complete unit agreement and any supplemental agreements that contain the terms
of the units.
General
We may issue units comprised
of one or more debt securities, shares of common stock, shares of preferred stock and warrants in any combination. Each unit will be issued
so that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights
and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide that the securities
included in the unit may not be held or transferred separately, at any time or at any time before a specified date.
We will describe in the applicable prospectus supplement
the terms of the series of units, including:
| ● | the designation and terms of the units and of the securities
comprising the units, including whether and under what circumstances those securities may be held or transferred separately; |
| ● | any provisions of the governing unit agreement that differ
from those described below; and |
| ● | any provisions for the issuance, payment, settlement, transfer
or exchange of the units or of the securities comprising the units. |
The provisions described in
this section, as well as those described under “Description of Capital Stock,” “Description of Debt Securities”
and “Description of Warrants” will apply to each unit and to any common stock, preferred stock, debt security or warrant
included in each unit, respectively.
Unit Agent
The name and address of
the unit agent, if any, for any units we offer will be set forth in the applicable prospectus supplement.
Issuance in Series
We may issue units in such
amounts and in numerous distinct series as we determine.
Enforceability of Rights by Holders of Units
Each unit agent will act solely
as our agent under the applicable unit agreement and will not assume any obligation or relationship of agency or trust with any holder
of any unit. A single bank or trust company may act as unit agent for more than one series of units. A unit agent will have no duty or
responsibility in case of any default by us under the applicable unit agreement or unit, including any duty or responsibility to initiate
any proceedings at law or otherwise, or to make any demand upon us. Any holder of a unit may, without the consent of the related unit
agent or the holder of any other unit, enforce by appropriate legal action its rights as holder under any security included in the unit.
We, the unit agents and any
of their agents may treat the registered holder of any unit certificate as an absolute owner of the units evidenced by that certificate
for any purpose and as the person entitled to exercise the rights attaching to the units so requested, despite any notice to the contrary.
See “Legal Ownership of Securities.”
LEGAL OWNERSHIP OF SECURITIES
We can issue securities in
registered form or in the form of one or more global securities. We describe global securities in greater detail below. We refer to those
persons who have securities registered in their own names on the books that we or any applicable trustee or depositary or warrant agent
maintain for this purpose as the “holders” of those securities. These persons are the legal holders of the securities. We
refer to those persons who, indirectly through others, own beneficial interests in securities that are not registered in their own names,
as “indirect holders” of those securities. As we discuss below, indirect holders are not legal holders, and investors in securities
issued in book-entry form or in street name will be indirect holders.
Book-Entry Holders
We may issue securities in
book-entry form only, as we will specify in the applicable prospectus supplement. This means securities may be represented by one or more
global securities registered in the name of a financial institution that holds them as depositary on behalf of other financial institutions
that participate in the depositary’s book-entry system. These participating institutions, which are referred to as participants,
in turn, hold beneficial interests in the securities on behalf of themselves or their customers.
Only the person in whose name
a security is registered is recognized as the holder of that security. Global securities will be registered in the name of the depositary
or its participants. Consequently, for global securities, we will recognize only the depositary as the holder of the securities, and we
will make all payments on the securities to the depositary. The depositary passes along the payments it receives to its participants,
which in turn pass the payments along to their customers who are the beneficial owners. The depositary and its participants do so under
agreements they have made with one another or with their customers; they are not obligated to do so under the terms of the securities.
As a result, investors in
a global security will not own securities directly. Instead, they will own beneficial interests in a global security, through a bank,
broker or other financial institution that participates in the depositary’s book-entry system or holds an interest through a participant.
As long as the securities are issued in global form, investors will be indirect holders, and not legal holders, of the securities.
Street Name Holders
We may terminate a global
security or issue securities that are not issued in global form. In these cases, investors may choose to hold their securities in their
own names or in “street name.” Securities held by an investor in street name would be registered in the name of a bank, broker
or other financial institution that the investor chooses, and the investor would hold only a beneficial interest in those securities through
an account he or she maintains at that institution.
For securities held in street
name, we or any applicable trustee or depositary will recognize only the intermediary banks, brokers and other financial institutions
in whose names the securities are registered as the holders of those securities, and we or any such trustee or depositary will make all
payments on those securities to them. These institutions pass along the payments they receive to their customers who are the beneficial
owners, but only because they agree to do so in their customer agreements or because they are legally required to do so. Investors who
hold securities in street name will be indirect holders, not legal holders, of those securities.
Legal Holders
Our obligations, as well as
the obligations of any applicable trustee or third party employed by us or a trustee, run only to the legal holders of the securities.
We do not have obligations to investors who hold beneficial interests in global securities, in street name or by any other indirect means.
This will be the case whether an investor chooses to be an indirect holder of a security or has no choice because we are issuing the securities
only in global form.
For example, once we make
a payment or give a notice to the holder, we have no further responsibility for the payment or notice even if that holder is required,
under agreements with its participants or customers or by law, to pass it along to the indirect holders but does not do so. Similarly,
we may want to obtain the approval of the holders to amend an indenture, to relieve us of the consequences of a default or of our obligation
to comply with a particular provision of an indenture, or for other purposes. In such an event, we would seek approval only from the legal
holders, and not the indirect holders, of the securities. Whether and how the legal holders contact the indirect holders is up to the
legal holders.
Special Considerations for Indirect Holders
If you hold securities through
a bank, broker or other financial institution, either in book-entry form because the securities are represented by one or more global
securities or in street name, you should check with your own institution to find out:
| ● | how it handles securities payments and notices; |
| ● | whether it imposes fees or charges; |
| ● | how it would handle a request for the holders’ consent,
if ever required; |
| ● | whether and how you can instruct it to send you securities
registered in your own name so you can be a legal holder, if that is permitted in the future; |
| ● | how it would exercise rights under the securities if there
were a default or other event triggering the need for holders to act to protect their interests; and |
| ● | if the securities are in book-entry form, how the depositary’s
rules and procedures will affect these matters. |
Global Securities
A global security is a security
that represents one or any other number of individual securities held by a depositary. Generally, all securities represented by the same
global securities will have the same terms.
Each security issued in book-entry
form will be represented by a global security that we issue to, deposit with and register in the name of a financial institution or its
nominee that we select. The financial institution that we select for this purpose is called the depositary. Unless we specify otherwise
in the applicable prospectus supplement, The Depository Trust Company, New York, NY, known as DTC, will be the depositary for all securities
issued in book-entry form.
A global security may not
be transferred to or registered in the name of anyone other than the depositary, its nominee or a successor depositary, unless special
termination situations arise. We describe those situations below under “— Special Situations When A Global Security Will
Be Terminated.” As a result of these arrangements, the depositary, or its nominee, will be the sole registered owner and legal
holder of all securities represented by a global security, and investors will be permitted to own only beneficial interests in a global
security. Beneficial interests must be held by means of an account with a broker, bank or other financial institution that in turn has
an account with the depositary or with another institution that does. Thus, an investor whose security is represented by a global security
will not be a legal holder of the security, but only an indirect holder of a beneficial interest in the global security.
If the prospectus supplement
for a particular security indicates that the security will be issued as a global security, then the security will be represented by a
global security at all times unless and until the global security is terminated. If termination occurs, we may issue the securities through
another book-entry clearing system or decide that the securities may no longer be held through any book-entry clearing system.
Special Considerations For Global Securities
As an indirect holder, an
investor’s rights relating to a global security will be governed by the account rules of the investor’s financial institution
and of the depositary, as well as general laws relating to securities transfers. We do not recognize an indirect holder as a holder of
securities and instead deal only with the depositary that holds the global security.
If securities are issued only
as global securities, an investor should be aware of the following:
| ● | an investor cannot cause the securities to be registered in
his or her name, and cannot obtain non-global certificates for his or her interest in the securities, except in the special situations
we describe below; |
| ● | an investor will be an indirect holder and must look to his
or her own bank or broker for payments on the securities and protection of his or her legal rights relating to the securities, as we
describe above; |
| ● | an investor may not be able to sell interests in the securities
to some insurance companies and to other institutions that are required by law to own their securities in non-book-entry form; |
| ● | an investor may not be able to pledge his or her interest
in the global security in circumstances where certificates representing the securities must be delivered to the lender or other beneficiary
of the pledge in order for the pledge to be effective; |
| ● | the depositary’s policies, which may change from time
to time, will govern payments, transfers, exchanges and other matters relating to an investor’s interest in the global security.
We and any applicable trustee have no responsibility for any aspect of the depositary’s actions or for its records of ownership
interests in the global security. We and the trustee also do not supervise the depositary in any way; |
| ● | the depositary may, and we understand that DTC will, require
that those who purchase and sell interests in the global security within its book-entry system use immediately available funds, and your
broker or bank may require you to do so as well; and |
| ● | financial institutions that participate in the depositary’s
book-entry system, and through which an investor holds its interest in the global security, may also have their own policies affecting
payments, notices and other matters relating to the securities. There may be more than one financial intermediary in the chain of ownership
for an investor. We do not monitor and are not responsible for the actions of any of those intermediaries. |
Special Situations When A Global Security Will
Be Terminated
In a few special situations
described below, a global security will terminate and interests in it will be exchanged for physical certificates representing those interests.
After that exchange, the choice of whether to hold securities directly or in street name will be up to the investor. Investors must consult
their own banks or brokers to find out how to have their interests in securities transferred to their own names, so that they will be
direct holders. We have described the rights of holders and street name investors above.
A global security will terminate
when the following special situations occur:
| ● | if the depositary notifies us that it is unwilling, unable
or no longer qualified to continue as depositary for that global security and we do not appoint another institution to act as depositary
within 90 days; |
| ● | if we notify any applicable trustee that we wish to terminate
that global security; or |
| ● | if an event of default has occurred with regard to securities
represented by that global security and has not been cured or waived. |
The applicable prospectus
supplement may also list additional situations for terminating a global security that would apply only to the particular series of securities
covered by the prospectus supplement. When a global security terminates, the depositary, and neither we, nor any applicable trustee, is
responsible for deciding the names of the institutions that will be the initial direct holders.
PLAN OF DISTRIBUTION
We may sell the securities being offered hereby
in one or more of the following ways from time to time:
| ● | through agents to the public or to investors; |
| ● | to underwriters for resale to the public or to investors; |
| ● | negotiated transactions; |
| ● | directly to investors; or |
| ● | through a combination of any of these methods of sale. |
As set forth in more detail below, the securities
may be distributed from time to time in one or more transactions:
| ● | at a fixed price or prices, which may be changed; |
| ● | at market prices prevailing at the time of sale; |
| ● | at prices related to such prevailing market prices; or |
We will set forth in a prospectus supplement the
terms of that particular offering of securities, including:
| ● | the name or names of any agents or underwriters; |
| ● | the purchase price of the securities being offered and the
proceeds we will receive from the sale; |
| ● | any over-allotment options under which underwriters may purchase
additional securities from us; |
| ● | any agency fees or underwriting discounts and other items
constituting agents’ or underwriters’ compensation; |
| ● | any initial public offering price; |
| ● | any discounts or concessions allowed or re-allowed or paid
to dealers; and |
| ● | any securities exchanges or markets on which such securities
may be listed. |
Only underwriters named in
an applicable prospectus supplement are underwriters of the securities offered by that prospectus supplement.
If underwriters are used in
an offering, we will execute an underwriting agreement with such underwriters and will specify the name of each underwriter and the terms
of the transaction (including any underwriting discounts and other terms constituting compensation of the underwriters and any dealers)
in a prospectus supplement. The securities may be offered to the public either through underwriting syndicates represented by managing
underwriters or directly by one or more investment banking firms or others, as designated. If an underwriting syndicate is used, the managing
underwriter(s) will be specified on the cover of the prospectus supplement. If underwriters are used in the sale, the offered securities
will be acquired by the underwriters for their own accounts and may be resold from time to time in one or more transactions, including
negotiated transactions, at a fixed public offering price or at varying prices determined at the time of sale. Any public offering price
and any discounts or concessions allowed or re-allowed or paid to dealers may be changed from time to time. Unless otherwise set forth
in the prospectus supplement, the obligations of the underwriters to purchase the offered securities will be subject to conditions precedent
and the underwriters will be obligated to purchase all of the offered securities if any are purchased.
We may grant to the underwriters
options to purchase additional securities to cover over-allotments, if any, at the public offering price, with additional underwriting
commissions or discounts, as may be set forth in a related prospectus supplement. The terms of any over-allotment option will be set forth
in the prospectus supplement for those securities.
If we use a dealer in the
sale of the securities being offered pursuant to this prospectus or any prospectus supplement, we will sell the securities to the dealer,
as principal. The dealer may then resell the securities to the public at varying prices to be determined by the dealer at the time
of resale. The names of the dealers and the terms of the transaction will be specified in a prospectus supplement.
We may sell the securities
directly or through agents we designate from time to time. We will name any agent involved in the offering and sale of securities
and we will describe any commissions we will pay the agent in the prospectus supplement. Unless the prospectus supplement states otherwise,
any agent will act on a best-efforts basis for the period of its appointment.
We may authorize agents or
underwriters to solicit offers by institutional investors to purchase securities from us at the public offering price set forth in the
prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on a specified date in the future. We
will describe the conditions to these contracts and the commissions we must pay for solicitation of these contracts in the prospectus
supplement.
In connection with the sale
of the securities, underwriters, dealers or agents may receive compensation from us or from purchasers of the common stock for whom they
act as agents in the form of discounts, concessions or commissions. Underwriters may sell the securities to or through dealers, and those
dealers may receive compensation in the form of discounts, concessions or commissions from the underwriters or commissions from the purchasers
for whom they may act as agents. Underwriters, dealers and agents that participate in the distribution of the securities, and any institutional
investors or others that purchase common stock directly and then resell the securities, may be deemed to be underwriters, and any discounts
or commissions received by them from us and any profit on the resale of the common stock by them may be deemed to be underwriting discounts
and commissions under the Securities Act.
We may provide agents and
underwriters with indemnification against particular civil liabilities, including liabilities under the Securities Act, or contribution
with respect to payments that the agents or underwriters may make with respect to such liabilities. Agents and underwriters may engage
in transactions with, or perform services for, us in the ordinary course of business.
We may engage in at the market
offerings into an existing trading market in accordance with Rule 415(a)(4) under the Securities Act. In addition, we may enter
into derivative transactions with third parties (including the writing of options), or sell securities not covered by this prospectus
to third parties in privately negotiated transactions. If the applicable prospectus supplement indicates, in connection with such a transaction,
the third parties may, pursuant to this prospectus and the applicable prospectus supplement, sell securities covered by this prospectus
and the applicable prospectus supplement. If so, the third party may use securities borrowed from us or others to settle such sales and
may use securities received from us to close out any related short positions. We may also loan or pledge securities covered by this prospectus
and the applicable prospectus supplement to third parties, who may sell the loaned securities or, in an event of default in the case of
a pledge, sell the pledged securities pursuant to this prospectus and the applicable prospectus supplement. The third party in such sale
transactions will be an underwriter and will be identified in the applicable prospectus supplement or in a post-effective amendment.
To facilitate an offering
of a series of securities, persons participating in the offering may engage in transactions that stabilize, maintain, or otherwise affect
the market price of the securities. This may include over-allotments or short sales of the securities, which involves the sale by persons
participating in the offering of more securities than have been sold to them by us. In those circumstances, such persons would cover such
over-allotments or short positions by purchasing in the open market or by exercising the over-allotment option granted to those persons.
In addition, those persons may stabilize or maintain the price of the securities by bidding for or purchasing securities in the open market
or by imposing penalty bids, whereby selling concessions allowed to underwriters or dealers participating in any such offering may be
reclaimed if securities sold by them are repurchased in connection with stabilization transactions. The effect of these transactions may
be to stabilize or maintain the market price of the securities at a level above that which might otherwise prevail in the open market.
Such transactions, if commenced, may be discontinued at any time. We make no representation or prediction as to the direction or magnitude
of any effect that the transactions described above, if implemented, may have on the price of our securities.
Unless otherwise specified
in the applicable prospectus supplement, each class or series of securities will be a new issue with no established trading market, other
than our common stock, which is listed on The Nasdaq Capital Market. We may elect to list any other class or series of securities on any
exchange or market, but we are not obligated to do so. It is possible that one or more underwriters may make a market in a class or series
of securities, but the underwriters will not be obligated to do so and may discontinue any market making at any time without notice. We
cannot give any assurance as to the liquidity of the trading market for any of the securities.
In order to comply with the
securities laws of some U.S. states or territories, if applicable, the securities offered pursuant to this prospectus will be sold in
those states only through registered or licensed brokers or dealers. In addition, in some states securities may not be sold unless they
have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement
is available and complied with.
Any underwriter may engage
in overallotment, stabilizing transactions, short covering transactions and penalty bids in accordance with Regulation M under the Exchange
Act. Overallotment involves sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids
to purchase the underlying security so long as the stabilizing bids do not exceed a specified maximum. Short covering transactions involve
purchases of the securities in the open market after the distribution is completed to cover short positions. Penalty bids permit the underwriters
to reclaim a selling concession from a dealer when the securities originally sold by the dealer are purchased in a covering transaction
to cover short positions. Those activities may cause the price of the securities to be higher than it would otherwise be. If commenced,
the underwriters may discontinue any of these activities at any time.
Any underwriters who are qualified
market makers on The Nasdaq Capital Market may engage in passive market making transactions in the securities on The Nasdaq Capital Market
in accordance with Rule 103 of Regulation M, during the business day prior to the pricing of the offering, before the commencement
of offers or sales of the securities. Passive market makers must comply with applicable volume and price limitations and must be identified
as passive market makers. In general, a passive market maker must display its bid at a price not in excess of the highest independent
bid for such security. If all independent bids are lowered below the passive market maker’s bid, however, the passive market maker’s
bid must then be lowered when certain purchase limits are exceeded.
LEGAL MATTERS
The validity of the issuance
of the securities offered hereby will be passed upon for us by Sheppard, Mullin, Richter & Hampton LLP, New York, NY. Additional
legal matters may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus
supplement.
EXPERTS
The Company’s financial
statements as of and for the year ended December 31, 2023, appearing in the Company’s Annual Report on Form 10-K for
the year ended December 31, 2023, have been audited by Grassi & Co., independent registered public accounting firm, as set
forth in their report, and have been incorporated herein by reference in reliance upon such report given on the authority of such firm
as experts in accounting and auditing, in giving said reports.
The Company’s financial
statements of as of and for the year ended December 31, 2022, appearing in the Company’s Annual Report on Form 10-K for
the year ended December 31, 2023, have been audited by CBIZ CPAs P.C. (formerly Mayer Hoffman McCann P.C.), independent registered
public accounting firm, as set forth in their report, and have been incorporated herein by reference in reliance upon such report given
on the authority of such firm as experts in accounting and auditing, in giving said reports.
WHERE YOU CAN FIND MORE INFORMATION
This prospectus constitutes
a part of the registration statement on Form S-3 that we have filed with the SEC under the Securities Act. As permitted
by the SEC’s rules, this prospectus and any accompanying prospectus supplement, which forms a part of the registration statement,
do not contain all of the information that is included in the registration statement. You will find additional information about us in
the registration statement. Any statement made in this prospectus or any accompanying prospectus supplement concerning legal documents
are not necessarily complete and you should read the documents that are filed as exhibits to the registration statement or otherwise filed
with the SEC for a more complete understanding of the document or matter.
We are subject to the reporting
requirements of the Exchange Act and file annual, quarterly and current reports, proxy statements and other information with the SEC.
You can read our SEC filings, including the registration statement, over the internet at the SEC’s website at http://www.sec.gov.
We also maintain a website at www.unicycive.com, at which you may access these materials free of charge as soon as reasonably
practicable after they are electronically filed with, or furnished to, the SEC. The information contained in, or that can be accessed
through, our website is not part of this prospectus.
You may also read and copy
any document we file with the SEC at its public reference facilities at 100 F Street, N.E., Room 1580, Washington, DC 20549. You may
also obtain copies of these documents at prescribed rates by writing to the Public Reference Section of the SEC at 100 F Street, N.E.,
Washington, D.C. 20549. Please call the SEC at 1-800-SEC-0330 for further information on the operation of the public reference facilities.
You may also request a copy of these filings, at no cost, by writing or telephoning us at: 4300 El Camino Real, Suite 210, Los Altos,
California, 94022, (650) 351-4495.
INCORPORATION OF DOCUMENTS BY REFERENCE
This prospectus is part of
the registration statement, but the registration statement includes and incorporates by reference additional information and exhibits.
The SEC permits us to “incorporate by reference” the information contained in documents we file with the SEC, which means
that we can disclose important information to you by referring you to those documents rather than by including them in this prospectus.
Information that is incorporated by reference is considered to be part of this prospectus and you should read it with the same care that
you read this prospectus and any subsequent prospectus supplement. Information that we file later with the SEC will automatically update
and supersede the information that is either contained, or incorporated by reference, in this prospectus, and will be considered to be
a part of this prospectus from the date those documents are filed.
We incorporate by reference
the documents listed below, all filings filed by us pursuant to the Exchange Act after the date of the registration statement of which
this prospectus and any accompanying prospectus supplement forms a part, and any future filings we make with the SEC under Sections 13(a),
13(c), 14 or 15(d) of the Exchange Act prior to the time that all securities covered by this prospectus have been sold; provided,
however, that we are not incorporating any information furnished under either Item 2.02 or Item 7.01 of any Current Report on Form 8-K:
| ● | our Annual Report on Form 10-K for the year ended December
31, 2023 filed with the SEC on March 28, 2024; |
| ● | our Quarterly Report on Form 10-Q for the quarter ended March
31, 2024 filed on May 13, 2024; |
| ● | our Quarterly Report on Form 10-Q for the quarter ended June
30, 2024 filed on August 14, 2024; |
| ● | our Quarterly Report on Form 10-Q for the quarter ended September
30, 2024 filed on November 13, 2024; |
| ● | our Current Reports on Form 8-K filed on February
21, 2024; March 14,
2024; March 14, 2024; June
20, 2024; June 26,
2024; July 2, 2024; July
15, 2024; July 15,
2024; September 25,
2024 and November 12, 2024; |
| ● | our definitive Proxy Statement on Schedule 14A for our 2024
Annual Meeting of Stockholders, filed with the SEC on April 26, 2024; and |
| ● | the description of our common stock contained in our Registration
Statement on Form 8-A filed with the Commission on July 6, 2021, including any amendments or reports filed with the SEC for the purposes
of updating such description. |
Any statements made in a
document incorporated by reference in this prospectus are deemed to be modified or superseded for purposes of this prospectus to the
extent that a statement in this prospectus or in any other subsequently filed document, which is also incorporated by reference, modifies
or supersedes the statement. Any statement made in this prospectus is deemed to be modified or superseded to the extent a statement in
any subsequently filed document, which is incorporated by reference in this prospectus, modifies or supersedes such statement. Any statement
so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of this prospectus.
The information relating
to us contained in this prospectus should be read together with the information in the documents incorporated by reference. In addition,
certain information, including financial information, contained in this prospectus or incorporated by reference in this prospectus should
be read in conjunction with documents we have filed with the SEC.
We will provide to each person,
including any beneficial holder, to whom a prospectus is delivered, at no cost, upon written or oral request, a copy of any or all of
the information that has been incorporated by reference in the prospectus but not delivered with the prospectus. Requests for documents
should be by writing to or telephoning us at the following address: Unicycive Therapeutics, Inc., 4300 El Camino Real, Suite 210, Los
Altos, California, 94022, (650) 351-4495. Exhibits to these filings will not be sent unless those exhibits have been specifically incorporated
by reference in such filings.
The information in this prospectus is not complete and may be changed.
We may not sell these securities or accept an offer to buy these securities until the registration statement filed with the U.S. Securities
and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and we are not soliciting an offer to
buy these securities in any state where the offer or sale is not permitted.
PRELIMINARY PROSPECTUS
Subject to completion, dated November 13, 2024
Up to $50,000,000
Common Stock
We have entered into a Sales
Agreement, or the Sales Agreement, with Guggenheim Securities, LLC, or Guggenheim Securities, dated November 13, 2024, relating to shares
of our common stock, par value $0.001 per share, offered by this prospectus. In accordance with the terms of the Sales Agreement, we may
offer and sell shares of our common stock having an aggregate offering price of up to $50 million, subject to certain limitations, as
described below, from time to time through or to Guggenheim Securities, acting as sales agent or principal.
Our common stock trades on
The Nasdaq Capital Market under the symbol “UNCY.” On November 8, 2024, the last reported sale price of our common stock on
The Nasdaq Capital Market was $0.59 per share.
Sales of our common stock,
if any, under this prospectus may be made in sales deemed to be an “at the market offering” as defined in Rule 415(a)(4) promulgated
under the Securities Act of 1933, as amended, or (the “Securities Act”). Guggenheim Securities is not required to sell any
specific number or dollar amount of securities, but will act as sales agent or principal on a best efforts basis and use commercially
reasonable efforts to sell on our behalf all of the shares of common stock requested to be sold by us, consistent with its normal trading
and sales practices, on mutually agreed terms between us and Guggenheim Securities. There is no arrangement for funds to be received in
any escrow, trust or similar arrangement.
Guggenheim Securities will
be entitled to compensation at a fixed commission rate equal to 3.0% of the gross sales price per common share sold under the Sales Agreement.
In connection with the sale of our common stock on our behalf, Guggenheim Securities will be deemed to be an “underwriter”
within the meaning of the Securities Act and the compensation of Guggenheim Securities will be deemed to be underwriting commissions or
discounts. We have also agreed to provide indemnification and contribution to Guggenheim Securities with respect to certain liabilities,
including liabilities under the Securities Act or the Securities Exchange Act of 1934, as amended or the Exchange Act.
As of the date of this prospectus
the aggregate market value of our outstanding common stock held by non-affiliates, or our public float, was approximately $51,608,469
based on 87,471,891 shares of outstanding common stock held by non-affiliates and a per share price of $0.59, the closing price of our
common stock on November 8, 2024, which is the highest closing price of our common stock on The Nasdaq Capital Market within the prior
60 days. Pursuant to General Instruction I.B.6 of Form S-3, in no event will we sell shares pursuant to this prospectus with a value
of more than one-third of the aggregate market value of our common stock held by non-affiliates in any 12-month period, so long as the
aggregate market value of our common stock held by non-affiliates is less than $75,000,000. During the 12-calendar month period that ends
on, and includes, the date of this prospectus (excluding this offering), we have not offered or sold shares of our common stock pursuant
to General Instruction I.B.6. of Form S-3 and, accordingly, may offer and sell additional shares of our common stock having an aggregate
offering price of up to $17,202,823 from time to time through Guggenheim Securities in accordance with the terms of the Sales Agreement.
If our public float increases such that we may sell additional amounts under the Sales Agreement and this prospectus, we will file an
amendment to the prospectus prior to making additional sales.
Investing in our common
stock involves a high degree of risk. See “Risk Factors” beginning on page S-7 of this prospectus, the accompanying prospectus,
and in the reports we file with the Securities and Exchange Commission pursuant to the Securities Exchange Act of 1934, as amended, incorporated
by reference into this prospectus before making a decision to invest in our common stock.
Neither the Securities
and Exchange Commission (the “SEC”) nor any state securities commission has approved or disapproved of these securities or
passed upon the adequacy or accuracy of this prospectus or the accompanying prospectus. Any representation to the contrary is a criminal
offense.
Guggenheim Securities
The date of this prospectus is November , 2024.
TABLE OF CONTENTS
PROSPECTUS
We are responsible for the information contained
and incorporated by reference in this prospectus, in any accompanying prospectus supplement, and in any related free writing prospectus
we prepare or authorize. We have not and Guggenheim Securities has not authorized anyone to give you any other information, and neither
we nor Guggenheim Securities take any responsibility for any other information that others may give you. If you are in a jurisdiction
where offers to sell, or solicitations of offers to purchase, the securities offered by this documentation are unlawful, or if you are
a person to whom it is unlawful to direct these types of activities, then the offer presented in this document does not extend to you.
The information contained in this document speaks only as of the date of this document, unless the information specifically indicates
that another date applies. Our business, financial condition, results of operations and prospects may have changed since those dates.
ABOUT THIS PROSPECTUS
This prospectus relates to
the offering of our common stock. Before buying any of the common stock that we are offering, we urge you to carefully read this prospectus,
together with the accompanying prospectus and the information incorporated by reference as described under the heading “Where You
Can Find More Information” and “Incorporation of Documents by Reference.” This prospectus is deemed a prospectus to
the accompanying prospectus contained in the registration statement of which this prospectus forms a part. These documents contain important
information that you should consider when making your investment decision.
This
prospectus is part of a “shelf” registration statement on Form S-3 that we filed with the Securities and Exchange
Commission (the “SEC”), using a “shelf” registration process. This prospectus describes the specific terms of
this offering of shares of common stock and also adds to and updates information contained in the documents incorporated by reference
into this prospectus.
This
prospectus relates only to an offering of up to $50,000,000 of shares of our common stock through Guggenheim Securities. These sales,
if any, will be made pursuant to the terms of the Sales Agreement entered into between us and Guggenheim Securities on November 13, 2024,
a copy of which is filed as an exhibit to the registration statement of which this prospectus is a part.
You should rely only on the
information contained or incorporated by reference in this prospectus and the accompanying prospectus or contained in any free writing
prospectus prepared by or on our behalf. We have not, and Guggenheim Securities has not, authorized anyone to provide you with different
information. The distribution of this prospectus and sale of these securities in certain jurisdictions may be restricted by law. We are
not, and Guggenheim Securities is not, making an offer to sell these securities in any jurisdiction where the offer or sale is not permitted.
You should assume that the information appearing in this prospectus, the accompanying prospectus and the documents incorporated by reference
in this prospectus, and in any free writing prospectus that we have authorized for use in connection with this offering, is accurate only
as of the date of those respective documents. Our business, financial condition, results of operations and prospects may have changed
since those dates.
Trademarks, service marks
or trade names of any other companies appearing in this prospectus are the property of their respective owners. Use or display by us
of trademarks, service marks or trade names owned by others is not intended to and does not imply a relationship between us and, or endorsement
or sponsorship by, the owners of the trademarks, service marks or trade names.
DISCLOSURE REGARDING FORWARD-LOOKING STATEMENTS
This prospectus, the accompanying
prospectus and the documents incorporated by reference herein and therein contain, in addition to historical information, certain forward-looking
statements within the meaning of Section 27A of the Securities Act and Section 21E of the Exchange Act that include information relating
to future events, future financial performance, strategies, expectations, competitive environment, regulation and availability of resources.
Such forward-looking statements include those that express plans, anticipation, intent, contingency, goals, targets or future development
and/or otherwise are not statements of historical fact. These forward-looking statements are based on our current expectations and projections
about future events and they are subject to risks and uncertainties known and unknown that could cause actual results and developments
to differ materially from those expressed or implied in such statements.
In some cases, you can
identify forward-looking statements by terminology, such as “expects,” “anticipates,” “intends,”
“estimates,” “plans,” “believes,” “seeks,” “may,” “should”, “could”
or the negative of such terms or other similar expressions. Accordingly, these statements involve estimates, assumptions and uncertainties
that could cause actual results to differ materially from those expressed in them. Any forward-looking statements are qualified in their
entirety by reference to the factors discussed throughout this prospectus or incorporated herein by reference.
Risks, uncertainties and
other factors that may cause our actual results, performance or achievements to be different from those expressed or implied in our written
or oral forward-looking statements may be found in this prospectus under the heading “Risk Factors” and in our Annual Report
on Form 10-K for the year ended December 31, 2023 under the headings “Risk Factors” and “Business,” as updated
in our Quarterly Report(s) on Form 10-Q.
Forward-looking statements
speak only as of the date they are made. You should not put undue reliance on any forward-looking statements. We assume no obligation
to update forward-looking statements to reflect actual results, changes in assumptions or changes in other factors affecting forward-looking
information, except to the extent required by applicable securities laws. If we do update one or more forward-looking statements, no
inference should be drawn that we will make additional updates with respect to those or other forward-looking statements.
New factors emerge from
time to time, and it is not possible for us to predict which factors will arise. In addition, we cannot assess the impact of each factor
on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those
contained in any forward-looking statements. We qualify all of the information presented in this prospectus and incorporated herein by
reference, and particularly our forward-looking statements, by these cautionary statements.
PROSPECTUS SUMMARY
The following summary highlights certain of
the information contained elsewhere in or incorporated by reference into this prospectus. Because this is only a summary, however, it
does not contain all the information you should consider before investing in our securities and it is qualified in its entirety by, and
should be read in conjunction with, the more detailed information included elsewhere in or incorporated by reference into this prospectus.
Before you make an investment decision, you should read this entire prospectus and the accompanying prospectus carefully, including the
risks of investing in our securities discussed under the section of this prospectus entitled “Risk Factors” and similar headings
in the other documents that are incorporated by reference into this prospectus. You should also carefully read the information incorporated
by reference into this prospectus, including our financial statements, and the exhibits to the registration statement of which this prospectus
is a part.
Unless the context otherwise requires, references
to “the Company,” “we,” “us,” and “our” refer to Unicycive Therapeutics, Inc., a Delaware
corporation, and its subsidiaries, unless the context otherwise requires.
Overview
We are a biotechnology company
dedicated to developing treatments for certain medical conditions. Currently, two of our programs are focused on kidney disease, an area
we believe we have the potential to offer medical benefit. As we grow the company and build our team, we intend to focus on identifying
medical conditions within and outside of kidney disease. Our current development programs are focused on two novel therapies: Oxylanthanum
Carbonate (“OLC), for treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis, and UNI 494, for treatment
of acute kidney injury (“AKI”). Oxylanthanum Carbonate and UNI 494 were initially developed by and licensed to us from Spectrum
Pharmaceuticals (“Spectrum”) and Sphaera Pharma (“Sphaera”), respectively. Spectrum conducted a Phase 1 clinical
trial with OLC in 2012, prior to the grant of our license in 2018. Sphaera conceived and performed initial characterization of various
potential pro-drug linkers, including the initial patent application, and performed some initial physiochemical characterization and preliminary
animal pharmacokinetic studies. As discussed herein, after completing IND enabling preclinical studies, we have conducted a Phase I clinical
study in healthy volunteers with UNI 494 in 2023.
Chronic kidney disease (CKD)
is the gradual loss of kidney (renal) function that can get worse over time leading to lasting damage and possibly Stage 5 or end-stage
renal disease (“ESRD”). Our initial focus is on developing drugs and getting them approved in the U.S., and then to partner
with global biopharmaceutical companies in the rest of the world. According to the United States Renal Data System (“USRDS”)
2022 Annual Data Report, 30 million (14%) of adults in the United States are estimated to have CKD and, of these, approximately 13 million
patients have advanced CKD (stage 3-5). Approximately 550,000 patients (ESRD) are on dialysis and of those, approximately 450,000 patients
(~80%) take phosphate binders to control hyperphosphatemia (too much phosphorus in their blood). The number of patients with ESRD in the
U.S. is increasing steadily and is projected to reach between 971,000 and 1,259,000 patients in 2030.
AKI is a sudden episode of
kidney failure or kidney damage (within the first 90 days of injury). After 90 days, the patient is considered to have progressed into
CKD. AKI affects more than 2 million U.S. patients and costs the healthcare system in excess of $9 billion per year. More than 300,000
patients per year in the U.S. die due to AKI that has many causes.
Our
business model is to license technologies and drugs in order to pursue development, regulatory approval, and commercialization of those
products in global markets. Many biotechnology companies utilize similar strategies of in-licensing and then developing and commercializing
drugs. We believe, however, that our management team’s broad network, expertise in the biopharmaceutical industry, and successful
track record gives us an advantage in identifying and bringing these assets into our company.
Pipeline
Our proprietary pipeline is comprised of our two product candidates
– OLC and UNI 494 – which are described below.
| ◦ | Figure 1 Unicycive Product Pipeline |
Recent Developments
New Drug Application
On
September 3, 2024, we submitted a New Drug Application, or NDA, to the U.S. Food and Drug Administration, or FDA, for OLC for the treatment
of hyperphosphatemia in patients with CKD on dialysis. On November 11, 2024, we announced that the FDA has accepted the NDA for OLC and
has set a Prescription Drug User Fee Act (PDUFA) target action date of June 28, 2025.
Company Information
We were incorporated as a
Delaware corporation on August 18, 2016. Our principal executive offices are located at 4300 El Camino Real, Suite 210, Los Altos, CA
94022 and our telephone number is (650) 351-4495. Our website address is http://www.unicycive.com. The information contained
on our website is not incorporated by reference into this prospectus, and you should not consider any information contained on, or that
can be accessed through, our website as part of this prospectus or in deciding whether to purchase our common stock. We have included
our website address as a factual reference and do not intend it to be an active link to our website.
THE OFFERING
Common stock offered by us: |
|
Shares of our common stock having an aggregate offering
price of up to $50,000,000. |
|
|
|
Common stock to be outstanding immediately after this offering: |
|
Up to 188,542,168 shares, assuming the
sale of up to 84,745,762 shares hereunder at a price of $0.59 per share, the closing price per share on The Nasdaq Capital Market
on November 8, 2024, for aggregate gross proceeds of $50,000,000. Actual shares issued will vary depending on the sales prices
under this offering. |
|
|
|
Manner of offering: |
|
“At the market offering” that may be
made from time to time on The Nasdaq Capital Market or other existing trading markets for our common stock through or to Guggenheim
Securities, acting as agent or principal. See “Plan of Distribution” on page S-13 of this prospectus. |
|
|
|
Use of Proceeds: |
|
Our management will retain broad discretion regarding the allocation
and use of the net proceeds. We currently intend to use the net proceeds from this offering for general corporate purposes, including
the development and commercialization of our products, research and development, general and administrative expenses, license or
technology acquisitions, and working capital and capital expenditures. We may also use a portion of the remaining net proceeds, if
any, to acquire or invest in complementary businesses, products and technologies, although we have no current commitments or agreements
with respect to any acquisitions as of the date hereof. See “Use of Proceeds” on page S-11. |
|
|
|
Risk factors: |
|
Investing in our common stock involves risks. See “Risk Factors”
beginning on page S-7 of this prospectus, the accompanying prospectus, and in our Form 10-K for the year ended December 31, 2023,
and in any updates to those risk factors in our reports on Form 10-Q or subsequent filings, incorporated by reference into this prospectus
for a discussion of factors you should carefully consider before deciding to invest in our common stock. |
|
|
|
Nasdaq Capital Market symbol: |
|
UNCY |
Unless we indicate otherwise, all information
in this prospectus is based on 103,796,406 shares of common stock outstanding as of November 13, 2024 and excludes as of that
date:
| ● | 13,671,140 shares of our common stock issuable upon exercise
of outstanding stock options under our stock incentive plans at a weighted average exercise price of $1.00 per share; |
| ● | 4,784,193 shares of our common stock issuable upon exercise
of outstanding warrants to purchase common stock at a weighted average exercise price of $6.00 per share; |
| ● | 17,176,000 shares of our common stock issuable upon conversion
of 8,416.24 shares Series A-2 Prime Preferred Stock; |
| ● | 47,852,430 shares of our common stock issuable upon conversion
of 25,840.3122 shares Series A-3 Convertible Preferred Stock issuable upon exercise of Tranche A Warrants; |
| ● | 43,502,206 shares of our common stock issuable upon conversion
of 25,666.30154 shares Series A-4 Convertible Preferred Stock issuable upon conversion of Tranche B Warrants; |
| ● | 69,603,531 shares of our common stock issuable upon conversion
of 51,506.61294 shares Series A-5 Convertible Preferred Stock issuable upon conversion of Tranche C Warrants; |
| ● | 7,444,000 shares of our common stock issuable upon conversion
of 7,444 shares of Series B-2 Preferred Stock; and |
| ● | 7,433,327 shares of common stock reserved for future grants
and awards under our stock incentive plans. |
RISK FACTORS
An investment in our common stock involves
a high degree of risk. Before deciding whether to invest in our common stock, you should consider carefully the risks described below
and discussed under the section captioned “Risk Factors” in our most recent Annual Report on Form 10-K and any subsequent
Quarterly Reports on Form 10-Q, which are each incorporated by reference in this prospectus and the accompanying prospectus in their
entirety, as well as any amendment or update to our risk factors reflected in subsequent filings with the SEC, together with other information
in this prospectus, the accompanying prospectus, and the information and documents incorporated by reference that we have authorized
for use in connection with this offering. If any of these risks actually occur, our business, financial condition, results of operations
or cash flows could be seriously harmed. This could cause the trading price of our common stock to decline, resulting in a loss of all
or part of your investment. The risks and uncertainties summarized and described below are not intended to be exhaustive and are not
the only ones we face. Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also impair
our business, prospects, financial condition and results of operations. Certain statements in this prospectus are forward-looking statements.
Please also see the section entitled “Disclosure Regarding Forward-Looking Statements.”
Risks Related to this Offering and Our Common
Stock
Our common stock price may be volatile and could fluctuate widely
in price, which could result in substantial losses for investors.
The market price of our common
stock historically has been, and we expect will continue to be, subject to significant fluctuations over short periods of time. For example,
since January 1, 2024, the closing price of our common stock ranged from a low of $0.2360 to a high of $1.79. These fluctuations may
be due to various factors, many of which are beyond our control, including:
| ● | technological
innovations or new products and services introduced by us or our competitors; |
| ● | clinical
trial results relating to our tests or those of our competitors; |
| ● | announcements
or press releases relating to the industry or to our own business or prospects; |
| ● | coverage
and reimbursement decisions by third party payors, such as Medicare and other managed care
organizations; |
| ● | regulation
and oversight of our product candidates and services, including by the FDA, Centers for Medicare
& Medicaid Services and comparable foreign agencies; |
| ● | the
establishment of partnerships with clinical reference laboratories; |
| ● | intellectual
property disputes; |
| ● | additions
or departures of key personnel; |
| ● | sales
of our common stock; |
| ● | our
ability to integrate operations, technology, products and services; |
| ● | our
ability to execute our business plan; |
| ● | operating
results below expectations; |
| ● | loss
of any strategic relationship; |
| ● | economic
and other external factors; |
| ● | catastrophic
weather and/or global disease outbreaks, such as the recent COVID-19 pandemic; and |
| ● | period-to-period
fluctuations in our financial results. |
In addition, market fluctuations,
as well as general political and economic conditions, could materially adversely affect the market price of our securities. Because we
are a development stage company with no revenue from operations to date, other than licensing, milestone and royalty income, you should
consider any one of these factors to be material. Our stock price may fluctuate widely as a result of any of the foregoing.
If you purchase our common stock in this
offering, you may incur immediate and substantial dilution in the net tangible book value of your shares.
The offering price per share
in this offering may exceed the net tangible book value per share of our common stock outstanding prior to this offering. Assuming that
an aggregate of 84,745,762 shares of our common stock are sold at a price of $0.59 per share, the last reported sale price of our common
stock on The Nasdaq Capital Market on November 8, 2024, for aggregate gross proceeds of approximately $50,000,000, and after deducting
commissions and estimated offering expenses payable by us, you would experience immediate dilution of $0.18 per share, representing the
difference between our pro forma as adjusted net tangible book value per share as of September 30, 2024 after giving effect to this offering
and the assumed public offering price. The exercise of outstanding stock options and warrants will result in further dilution of your
investment.
This dilution would be due
to the substantially lower price paid by some of our investors who purchased shares prior to this offering as compared to the assumed
price offered to the public in this offering and the exercise of stock options granted to our employees, directors and consultants as
well as the exercise of outstanding warrants and conversion of outstanding preferred stock. As a result of the dilution to investors
purchasing shares in this offering, investors may receive significantly less than the purchase price paid in this offering, if anything,
in the event of our liquidation. Further, because we expect we will need to raise additional capital to fund our future activities, we
may in the future sell substantial amounts of common stock or securities exercisable or convertible into or exchangeable for common stock.
Because we will have broad discretion and
flexibility in how the net proceeds from this offering are used, we may use the net proceeds in ways with which you disagree.
We intend to use the net
proceeds from this offering for general corporate purposes, including the development and commercialization of our products, research
and development, general and administrative expenses, license or technology acquisitions, and working capital and capital expenditures.
See “Use of Proceeds” on page S-11. We have not allocated specific amounts of the net proceeds from this offering for any
of the foregoing purposes. Accordingly, our management will have significant discretion and flexibility in applying the net proceeds
of this offering. You will be relying on the judgment of our management with regard to the use of these net proceeds, and you will not
have the opportunity, as part of your investment decision, to assess whether the net proceeds are being used appropriately. It is possible
that the net proceeds will be invested in a way that does not yield a favorable, or any, return for us. The failure of our management
to use such funds effectively could have a material adverse effect on our business, financial condition, operating results and cash flow.
You may experience future dilution as a
result of future equity offerings and other issuances of our securities. In addition, this offering and future equity offerings and other
issuances of our common stock or other securities may adversely affect our common stock price.
In order to raise additional
capital, we may in the future offer additional shares of our common stock or other securities exercisable or convertible into or exchangeable
for our common stock at prices that may not be the same as the price per share in this offering. We may not be able to sell shares or
other securities in any other offering at a price per share that is equal to or greater than the price per share paid by investors in
this offering, and investors purchasing shares or other securities in the future could have rights superior to existing stockholders.
The price per share at which we sell additional shares of our common stock or securities exercisable or convertible into common stock
in future transactions may be higher or lower than the price per share in this offering. You will incur dilution upon exercise of any
outstanding stock options or warrants, the conversion of any outstanding preferred stock or upon the issuance of shares of common stock
under our stock incentive programs. In addition, the sale of shares in this offering and any future sales of a substantial number of
shares of our common stock in the public market, or the perception that such sales may occur, could adversely affect the price of our
common stock. We cannot predict the effect, if any, that market sales of those shares of common stock or the availability of those shares
of common stock for sale will have on the market price of our common stock.
We have not paid dividends on our common
stock in the past and do not expect to pay dividends on our common stock for the foreseeable future. Any return on investment may be
limited to the value of our common stock.
We have never paid any cash
dividends on our common stock. We expect that any income received from operations will be devoted to our future operations and growth.
We do not expect to pay cash dividends on our common stock in the near future. Payment of dividends would depend upon our profitability
at the time, cash available for those dividends, and other factors that our Board of Directors may consider relevant. If we do not pay
dividends, our common stock may be less valuable because a return on an investor’s investment will only occur if our stock price
appreciates. Furthermore, the terms of any debt agreements may also preclude us from paying dividends. Investors in our common stock
should not rely on an investment in our company if they require dividend income. We expect that only appreciation of the price of our
common stock, if any, will provide a return to investors in this offering for the foreseeable future.
The common stock offered hereby will be
sold in “at the market” offerings, and investors who buy shares at different times will likely pay different prices.
Investors who purchase shares
in this offering at different times will likely pay different prices, and so may experience different outcomes in their investment results.
We will have discretion, subject to market demand, to vary the timing, prices, and numbers of shares sold, and there is no minimum or
maximum sales price. Investors may experience a decline in the value of their shares as a result of share sales made at prices lower
than the prices they paid.
The actual number of shares we will issue
under the Sales Agreement, at any one time or in total, is uncertain.
Subject to certain limitations
in the Sales Agreement and compliance with applicable law, we have the discretion to deliver placement notices to Guggenheim Securities
at any time throughout the term of the Sales Agreement. The number of shares that are sold by Guggenheim Securities after delivering a
placement notice will fluctuate based on the market price of the common stock during the sales period and limits we set with Guggenheim
Securities. Because the price per share of each share sold will fluctuate based on the market price of our common stock during the sales
period, it is not possible at this stage to predict the number of shares that will be ultimately issued.
We are a smaller reporting company, and
we cannot be certain if the reduced disclosure requirements applicable to smaller reporting companies will make our common stock less
attractive to investors.
We are currently a “smaller
reporting company,” as defined in Rule 405 under the Securities Act. As a smaller reporting company, we take advantage of certain
exemptions from various reporting requirements that are applicable to other public companies that are not “smaller reporting companies,”
including, but not limited to, reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements
and exemptions from the provisions of Section 404(b) of the Sarbanes-Oxley Act of 2002, as amended, requiring that independent registered
public accounting firms provide an attestation report on the effectiveness of internal control over financial reporting. Decreased disclosures
in our SEC filings due to our status as a “smaller reporting company” may make it harder for investors to analyze our results
of operations and financial prospects. We cannot predict if investors will find our common stock less attractive if we rely on these
exemptions. If some investors find our common stock less attractive as a result, there may be a less active trading market for our common
stock and our share price may be more volatile.
If we fail to
comply with the continued listing requirements of The Nasdaq Capital Market, our common stock may be delisted and the price of our common
stock and our ability to access the capital markets could be negatively impacted.
Our common stock is currently
listed on The Nasdaq Capital Market and the continued listing of our common stock on The Nasdaq Capital Market is contingent on our continued
compliance with a number of listing requirements. If we are unable to comply with the continued listing requirements of The Nasdaq Capital
Market, our common stock would be delisted from The Nasdaq Capital Market, which would limit investors’ ability to effect transactions
in our common stock and subject us to additional trading restrictions. In order to maintain our listing, we must maintain certain share
prices, financial and share distribution targets, including maintaining a minimum amount of stockholders’ equity and a minimum number
of public stockholders, as well as satisfy other listing requirements of The Nasdaq Capital Market. In addition to these objective standards,
Nasdaq Capital Market may delist the securities of any issuer for other reasons involving the judgment of Nasdaq Capital Market.
On July 9, 2024, we received
written notice from The Nasdaq Stock Market, LLC (“Nasdaq”) that we were not in compliance with Nasdaq Listing
Rule 5550(a)(2), as the minimum bid price of our common stock had been below $1.00 per share for 30 consecutive business days. In
accordance with Nasdaq Listing Rule 5810, we have a period of 180 calendar days, or until January 6, 2025, to regain compliance with
the minimum bid price requirement and market value of common stock requirement. To regain compliance with The Nasdaq bid price requirement,
the closing bid price of our common stock must meet or exceed $1.00 per share for at least 10 consecutive business days during this 180
calendar day period. In the event we do not regain compliance by January 6, 2025, we may be eligible for an additional 180 calendar day
grace period; however, there can be no assurance that we will regain compliance with The Nasdaq continued listing requirements.
In addition, on July 11, 2024,
the Company received Notice from Nasdaq notifying the Company that for the last 30 consecutive business days prior to the date of the
Notice, the Company’s minimum Market Value of Listed Securities was below the minimum of $35 million required for continued listing
on The Nasdaq Capital Market pursuant to Nasdaq Listing Rule 5550(b)(2) (the “MVLS Requirement”). In accordance with Nasdaq
Listing Rule 5810(c)(3)(C), Nasdaq has provided the Company with 180 calendar days, or until January 7, 2025 (the “Compliance Date”),
to regain compliance with the MVLS Requirement. If the Company regains compliance with the MVLS Requirement, Nasdaq will provide written
confirmation to the Company and close the matter. Nasdaq has determined that for the last 10 consecutive business days, from September
10 to September 23, 2024, the Company’s market value of listed securities has been $35,000,000 or greater. On September 24, 2024,
the Company received notice from Nasdaq that the Company has regained compliance with the minimum market value requirement for continued
listing on The Nasdaq Capital Market.
There is no assurance that
we will be able to maintain compliance with The Nasdaq Capital Market continued listing standards and/or continue our listing on The Nasdaq
Capital Market in the future.
If The Nasdaq Capital Market
delists our common stock from trading on its exchange and we are not able to list our securities on another national securities exchange,
we expect the common stock would qualify to be quoted on an over-the-counter market. If this were to occur, we could face significant
material adverse consequences, including:
| ● | a
limited availability of market quotations for our securities; |
| ● | reduced
liquidity for our securities; |
| | |
| ● | substantially
impair our ability to raise additional funds; |
| | |
| ● | the
loss of institutional investor interest and a decreased ability to issue additional securities
or obtain additional financing in the future; |
| | |
| ● | a determination that our common stock is a “penny stock,”
which will require brokers trading in our common stock to adhere to more stringent rules and possibly result in a reduced level of trading
activity in the secondary trading market for our securities; |
| | |
| ● | a
limited amount of news and analyst coverage; and |
| | |
| ● | potential
breaches of representations or covenants of our agreements pursuant to which we made representations
or covenants relating to our compliance with applicable listing requirements, which, regardless
of merit, could result in costly litigation, significant liabilities and diversion of our
management’s time and attention and could have a material adverse effect on our financial
condition, business and results of operations. |
USE OF PROCEEDS
We may issue and sell shares
of our common stock having aggregate sales proceeds of up to $50,000,000 from time to time. Because there is no minimum offering amount
required as a condition to close this offering, the actual total public offering amount, commissions and proceeds to us, if any, are not
determinable at this time. There can be no assurance that we will sell any shares under or fully utilize our Sales Agreement with Guggenheim
Securities as a source of financing.
We intend to use the net
proceeds from the sale of the shares for general corporate purposes, including the development and commercialization of our products,
research and development, general and administrative expenses, license or technology acquisitions, and working capital and capital expenditures.
The expected use of the net proceeds from this offering represents our intentions based upon our current plans and business conditions,
which could change in the future as our plans and business conditions evolve. The amounts and timing of our actual expenditures will
depend on numerous factors, including the factors described under “Risk Factors” in this prospectus and in the documents
incorporated by reference herein, as well as the amount of cash used in our operations. We may find it necessary or advisable to use
the net proceeds for other purposes, and we will have broad discretion in the application of the net proceeds. We may also use a portion
of the remaining net proceeds, if any, to acquire or invest in complementary businesses, products and technologies, although we have
no current commitments or agreements with respect to any acquisitions as of the date hereof. Pending the uses described above, we plan
to invest the net proceeds from this offering in short- and intermediate-term, interest-bearing obligations, investment-grade instruments,
certificates of deposit or direct or guaranteed obligations of the U.S. government.
DILUTION
If you invest in our common
stock in this offering, your ownership interest will be immediately diluted to the extent of the difference between the public offering
price per share and the as adjusted net tangible book value per share after this offering. As of September 30, 2024, our net tangible
book value was $27.9 million, or $0.28 per share. Net tangible book value per share represents our total tangible assets (excluding deferred
issuance costs) less our total liabilities, divided by the number of shares outstanding. Dilution with respect to net tangible book value
per share represents the difference between the amount per share paid by purchasers of shares of common stock in this offering and the
net tangible book value per share of our common stock immediately after this offering.
Our pro forma net tangible
book value on September 30, 2024 was approximately $27.9 million, or $0.27 per share, after giving effect to (i) the issuance of an aggregate
of 5,500,000 shares of our common stock upon the conversion of outstanding Series A-2 Prime Preferred Stock; and (ii) 438,000 shares
of our common stock upon the conversion of outstanding shares of Series B-2 Preferred Stock. “Net tangible book value” is
total assets minus the sum of liabilities and intangible assets. “Net tangible book value per share” is net tangible book
value divided by the total number of shares outstanding.
After giving effect to the
sale of 84,745,762 shares of common stock in this offering at an assumed public offering price of $0.59 per share, the last reported sale
price of our common stock on The Nasdaq Capital Market on November 8, 2024, and after deducting commissions and estimated aggregate offering
expenses payable by us, our pro forma as adjusted net tangible book value as of September 30, 2024 would have been approximately $77.9
million, or approximately $0.41 per share of common stock. This represents an immediate increase in pro forma as adjusted net tangible
book value of $0.14 per share to our existing stockholders and an immediate dilution in net tangible book value of $0.18 per share to
investors participating in this offering at the assumed public offering price.
Assumed public offering price per share | |
| | | |
$ | 0.59 | |
Pro forma net tangible book value per share as of September 30, 2024 | |
$ | 0.27 | | |
| | |
Increase in pro forma net tangible
per share attributable to this offering | |
| 0.14 | | |
| | |
Pro forma as adjusted net tangible
book value per share as of September 30, 2024, after giving effect to this offering | |
| | | |
| 0.41 | |
Dilution in pro forma net tangible
book value per share to investors participating in this offering | |
| | | |
$ | 0.18 | |
The information discussed
above is illustrative only and will adjust based on the actual public offering price and other terms of this offering determined at pricing.
The above discussion and
table is based on 97,858,406 shares of common stock outstanding as of September 30, 2024 and excludes as of that date:
| ● | 13,671,140 shares of our common stock issuable upon exercise
of outstanding stock options under our stock incentive plans at a weighted average exercise price of $1.00 per share; |
| ● | 4,784,193 shares of our common stock issuable upon exercise
of outstanding warrants to purchase common stock at a weighted average exercise price of $6.00 per share; |
| ● | 22,676,000 shares of our common stock issuable upon conversion of 11,111.24
shares Series A-2 Prime Preferred Stock; |
| ● | 47,852,430 shares of our common stock issuable upon conversion
of 25,840.3122 shares Series A-3 Convertible Preferred Stock issuable upon exercise of Tranche A Warrants; |
| ● | 43,502,206 shares of our common stock issuable upon conversion
of 25,666.30154 shares Series A-4 Convertible Preferred Stock issuable upon conversion of Tranche B Warrants; |
| ● | 69,603,531 shares of our common stock issuable upon conversion
of 51,506.61294_ shares Series A-5 Convertible Preferred Stock issuable upon conversion of Tranche C Warrants; |
| ● | 7,882,000 shares of our common stock issuable upon conversion of 7,882
shares of Series B-2 Preferred Stock; and |
| ● | 7,433,327 shares of common stock reserved for future grants
and awards under our stock incentive plans. |
PLAN OF DISTRIBUTION
We have entered into the Sales
Agreement with Guggenheim Securities, under which we may offer and sell up to $50,000,000 of our shares of common stock from time to time
through or to Guggenheim Securities acting as agent or principal. Sales of our shares of common stock, if any, under this prospectus will
be made by any method that is deemed to be an “at the market offering” as defined in Rule 415(a)(4) under the Securities Act.
Each time we wish to issue
and sell shares of common stock under the Sales Agreement, we will notify Guggenheim Securities of the number of shares to be issued,
the dates on which such sales are anticipated to be made, any limitation on the number of shares to be sold in any one day and any minimum
price below which sales may not be made. Once we have so instructed Guggenheim Securities, unless Guggenheim Securities declines to accept
the terms of such notice, Guggenheim Securities has agreed to use its commercially reasonable efforts consistent with its normal trading
and sales practices to sell such shares up to the amount specified on such terms. The obligations of Guggenheim Securities under the Sales
Agreement to sell our shares of common stock are subject to a number of conditions that we must meet.
The settlement of sales of
shares between us and Guggenheim Securities is generally anticipated to occur on the first trading day following the date on which the
sale was made. Sales of our shares of common stock as contemplated in this prospectus will be settled through the facilities of The Depository
Trust Company or by such other means as we and Guggenheim Securities may agree upon. There is no arrangement for funds to be received
in an escrow, trust or similar arrangement.
We will pay Guggenheim Securities
a commission equal to 3.0% of the aggregate gross proceeds we receive from each sale of our shares of common stock. Because there is no
minimum offering amount required as a condition to close this offering, the actual total public offering amount, commissions and proceeds
to us, if any, are not determinable at this time. In addition, we have agreed to reimburse Guggenheim Securities for the fees and disbursements
of its counsel, payable upon execution of the Sales Agreement, in an amount not to exceed $75,000. Additionally, pursuant to the terms
of the Sales Agreement, we agreed to reimburse Guggenheim Securities for the documented fees and costs of its legal counsel reasonably
incurred in connection with Guggenheim Securities’ ongoing diligence arising from the transactions contemplated by the Sales Agreement
in an amount not to exceed $25,000 per calendar quarter, in addition to certain ongoing disbursements of its legal counsel, unless we
and Guggenheim Securities otherwise agree. We estimate that the total expenses for the offering, excluding any commissions or expense
reimbursement payable to Guggenheim Securities under the terms of the Sales Agreement, will be approximately $[ ]. The remaining sale
proceeds, after deducting any other transaction fees, will equal our net proceeds from the sale of such shares.
Guggenheim Securities will
provide written confirmation to us before the open on The Nasdaq Capital Market on the day following each day on which our shares of common
stock are sold under the Sales Agreement. Each confirmation will include the number of shares sold on that day, the aggregate gross proceeds
of such sales and the proceeds to us.
In connection with the sale
of our shares of common stock on our behalf, Guggenheim Securities will be deemed to be an “underwriter” within the meaning
of the Securities Act, and the compensation of Guggenheim Securities will be deemed to be underwriting commissions or discounts. We have
agreed to indemnify Guggenheim Securities against certain civil liabilities, including liabilities under the Securities Act. We have also
agreed to contribute to payments Guggenheim Securities may be required to make in respect of such liabilities.
This offering of our shares
of common stock pursuant to the Sales Agreement will terminate upon the earlier of (i) the sale of all shares of common stock subject
to the Sales Agreement and (ii) the termination of the Sales Agreement as permitted therein.
This summary of the material
provisions of the Sales Agreement does not purport to be a complete statement of its terms and conditions. A copy of the Sales Agreement
is filed as an exhibit to the registration statement of which this prospectus forms a part.
Guggenheim Securities and
its affiliates may in the future provide various investment banking, commercial banking, financial advisory and other financial services
for us and our affiliates, for which services they may in the future receive customary fees. In the course of its business, Guggenheim
Securities may actively trade our securities for its own account or for the accounts of customers, and, accordingly, Guggenheim Securities
may at any time hold long or short positions in such securities.
A prospectus supplement and
the accompanying prospectus in electronic format may be made available on a website maintained by Guggenheim Securities, and Guggenheim
Securities may distribute the prospectus supplement and the accompanying prospectus electronically.
LEGAL MATTERS
The validity of the securities
offered hereby will be passed upon for us by Sheppard, Mullin, Richter & Hampton LLP, New York, New York. Guggenheim Securities is
being represented in connection with this offering by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., Boston, Massachusetts.
EXPERTS
The Company’s financial
statements as of and for the year ended December 31, 2023, appearing in the Company’s Annual Report on Form 10-K for
the year ended December 31, 2023, have been audited by Grassi & Co., independent registered public accounting firm, as set forth
in their report, and have been incorporated herein by reference in reliance upon such report given on the authority of such firm as experts
in accounting and auditing, in giving said reports.
The Company’s financial
statements of as of and for the year ended December 31, 2022, appearing in the Company’s Annual Report on Form 10-K for
the year ended December 31, 2023, have been audited by CBIZ CPAs P.C. (formerly Mayer Hoffman McCann P.C.), independent registered
public accounting firm, as set forth in their report, and have been incorporated herein by reference in reliance upon such report given
on the authority of such firm as experts in accounting and auditing, in giving said reports.
WHERE YOU CAN FIND MORE INFORMATION
This prospectus constitutes
a part of the registration statement on Form S-3 that we have filed with the SEC under the Securities Act. As permitted
by the SEC’s rules, this prospectus and any accompanying prospectus, which forms a part of the registration statement, do not contain
all of the information that is included in the registration statement. You will find additional information about us in the registration
statement. Any statement made in this prospectus or any accompanying prospectus concerning legal documents are not necessarily complete
and you should read the documents that are filed as exhibits to the registration statement or otherwise filed with the SEC for a more
complete understanding of the document or matter.
We are subject to the reporting
requirements of the Exchange Act and file annual, quarterly and current reports, proxy statements and other information with the SEC.
You can read our SEC filings, including the registration statement, over the internet at the SEC’s website at http://www.sec.gov.
We also maintain a website at www.unicycive.com, at which you may access these materials free of charge as soon as reasonably
practicable after they are electronically filed with, or furnished to, the SEC. The information contained in, or that can be accessed
through, our website is not part of this prospectus.
You may also read and copy
any document we file with the SEC at its public reference facilities at 100 F Street, N.E., Room 1580, Washington, DC 20549. You may
also obtain copies of these documents at prescribed rates by writing to the Public Reference Section of the SEC at 100 F Street, N.E.,
Washington, D.C. 20549. Please call the SEC at 1-800-SEC-0330 for further information on the operation of the public reference facilities.
You may also request a copy of these filings, at no cost, by writing or telephoning us at: Unicycive Therapeutics, Inc., 4300 El Camino
Real, Suite 210, Los Altos, California, 94022; (650) 351-4495.
INCORPORATION OF DOCUMENTS BY REFERENCE
The SEC permits us to “incorporate
by reference” the information contained in documents we file with the SEC, which means that we can disclose important information
to you by referring you to those documents rather than by including them in this prospectus. Information that is incorporated by reference
is considered to be part of this prospectus and you should read it with the same care that you read this prospectus and the accompanying
prospectus. Information that we file later with the SEC will automatically update and supersede the information that is either contained,
or incorporated by reference, in this prospectus, and will be considered to be a part of this prospectus from the date those documents
are filed.
We incorporate by reference
the documents listed below, all filings filed by us pursuant to the Exchange Act after the date of the registration statement of which
this prospectus and the accompanying prospectus forms a part, and any future filings we make with the SEC under Sections 13(a), 13(c),
14 or 15(d) of the Exchange Act prior to the time that all securities covered by this prospectus have been sold; provided, however,
that we are not incorporating any information furnished under either Item 2.02 or Item 7.01 of any Current Report on Form 8-K:
| ● | our Annual Report on Form 10-K for the year ended December
31, 2023 filed with the SEC on March 28, 2024; |
| ● | our Quarterly Report on Form 10-Q for the quarter ended March
31, 2024 filed on May 13, 2024; |
| ● | our Quarterly Report on Form 10-Q for the quarter ended June
30, 2024 filed on August 14, 2024; |
| ● | our Quarterly Report on Form 10-Q for the quarter ended September
30, 2024 filed on November 13, 2024 |
| ● | our Current Reports on Form 8-K filed on February
21, 2024, March 14,
2024, March 14, 2024; June
20, 2024; June 26,
2024; July 2, 2024; July
15, 2024; July 15,
2024; September 25,
2024; and November 12, 2024; |
| ● | our definitive Proxy Statement on Schedule 14A for our 2024
Annual Meeting of Stockholders, filed with the SEC on April 26, 2024; and |
| ● | the description of our common stock contained in our Registration
Statement on Form 8-A filed with the Commission on July 6, 2021, including any amendments or reports filed with the SEC for the purposes
of updating such description. |
Any statements made in a
document incorporated by reference in this prospectus are deemed to be modified or superseded for purposes of this prospectus to the
extent that a statement in this prospectus or in any other subsequently filed document, which is also incorporated by reference, modifies
or supersedes the statement. Any statement made in this prospectus is deemed to be modified or superseded to the extent a statement in
any subsequently filed document, which is incorporated by reference in this prospectus, modifies or supersedes such statement. Any statement
so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of this prospectus.
The information relating
to us contained in this prospectus should be read together with the information in the documents incorporated by reference. In addition,
certain information, including financial information, contained in this prospectus, the accompanying prospectus or incorporated by reference
in this prospectus and the accompanying prospectus should be read in conjunction with documents we have filed with the SEC.
We will provide to each person,
including any beneficial holder, to whom a prospectus is delivered, at no cost, upon written or oral request, a copy of any or all of
the information that has been incorporated by reference in the prospectus but not delivered with the prospectus. Requests for documents
should be by writing to or telephoning us at the following address: Unicycive Therapeutics, Inc., 4300 El Camino Real, Suite 210, Los
Altos, California, 94022; (650) 351-4495. Exhibits to these filings will not be sent unless those exhibits have been specifically incorporated
by reference in such filings.
Up to $50,000,000
Shares of Common Stock
PROSPECTUS
Guggenheim Securities
November [ ], 2024
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 14. Other Expenses of Issuance and Distribution.
The following table sets
forth an estimate of the fees and expenses relating to the issuance and distribution of the securities being registered hereby, other
than underwriting discounts and commissions, all of which shall be borne by the registrant.
All of such fees and expenses are estimated:
| |
Amount | |
SEC registration fee | |
$ | 15,310.00 | |
FINRA filing fee | |
| 15,500.00 | |
Accounting fees and expenses | |
| ** | |
Legal fees and expenses | |
| ** | |
Miscellaneous fees and expenses | |
| ** | |
Total expenses | |
$ | ** | |
| ** | These fees and expenses
depend on the securities offered and the number of issuances and accordingly cannot be estimated
at this time. |
Item 15. Indemnification of Directors and
Officers.
Section 102 of the DGCL
permits a corporation to eliminate the personal liability of directors of a corporation to the corporation or its stockholders for monetary
damages for a breach of fiduciary duty as a director, except where the director breached his duty of loyalty, failed to act in good faith,
engaged in intentional misconduct or knowingly violated a law, authorized the payment of a dividend or approved a stock repurchase in
violation of Delaware corporate law or obtained an improper personal benefit. Our amended and restated certificate of incorporation provides
that no director of the Company shall be personally liable to it or its stockholders for monetary damages for any breach of fiduciary
duty as a director, notwithstanding any provision of law imposing such liability, except to the extent that the DGCL prohibits the elimination
or limitation of liability of directors for breaches of fiduciary duty.
Section 145 of the DGCL provides
that a corporation has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving at the
request of the corporation for another corporation, partnership, joint venture, trust or other enterprise in related capacities against
expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person
in connection with an action, suit or proceeding to which he was or is a party or is threatened to be made a party to any threatened,
ending or completed action, suit or proceeding by reason of such position, if such person acted in good faith and in a manner he reasonably
believed to be in or not opposed to the best interests of the corporation, and, in any criminal action or proceeding, had no reasonable
cause to believe his conduct was unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification
shall be made with respect to any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation
unless and only to the extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability
but in view of all of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which
the Court of Chancery or such other court shall deem proper.
Our amended and restated
certificate of incorporation and amended and restated bylaws will provide indemnification for our directors and officers to the fullest
extent permitted by the DGCL. We will indemnify each person who was or is a party or is threatened to be made a party to any threatened
or pending action by or in the right of us by reason of the fact that he or she is or was, or has agreed to become, a director or officer,
or is or was serving, or has agreed to serve, at our request as a director, officer, partner, employee or trustee of, or in a similar
capacity with, another corporation, partnership, joint venture, trust or other enterprise (all such persons being referred to as an “Indemnitee”),
or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees),
judgments, fines and amounts paid in settlement actually and reasonably incurred in connection with such action, suit or proceeding and
any appeal therefrom, if such Indemnitee acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to,
our best interests, and, with respect to any criminal action or proceeding, he or she had no reasonable cause to believe his or her conduct
was unlawful. Our amended and restated certificate of incorporation, as amended, and bylaws provide that we will indemnify any Indemnitee
who was or is a party to an action or suit by or in the right of us to procure a judgment in our favor by reason of the fact that the
Indemnitee is or was, or has agreed to become, a director or officer, or is or was serving, or has agreed to serve, at our request as
a director, officer, partner, employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture,
trust or other enterprise, or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including
attorneys’ fees) and, to the extent permitted by law, amounts paid in settlement actually and reasonably incurred in connection
with such action, suit or proceeding, and any appeal therefrom, if the Indemnitee acted in good faith and in a manner he or she reasonably
believed to be in, or not opposed to, our best interests, except that no indemnification shall be made with respect to any claim, issue
or matter as to which such person shall have been adjudged to be liable to us, unless a court determines that, despite such adjudication
but in view of all of the circumstances, he or she is entitled to indemnification of such expenses. Notwithstanding the foregoing, to
the extent that any Indemnitee has been successful, on the merits or otherwise, he or she will be indemnified by us against all expenses
(including attorneys’ fees) actually and reasonably incurred in connection therewith. Expenses must be advanced to an Indemnitee
under certain circumstances.
We maintain a general liability
insurance policy that covers certain liabilities of directors and officers of our corporation arising out of claims based on acts or
omissions in their capacities as directors or officers.
Insofar as indemnification
for liabilities arising under the Securities Act of 1933, as amended (the “Securities Act”) may be permitted to our directors,
officers and controlling persons pursuant to the foregoing provisions, or otherwise, we have been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will,
unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the
final adjudication of such issue.
Item 16. Exhibits.
Exhibit Number |
|
Description |
1.1** |
|
Sales Agreement, dated as of November 13, 2024, between the Company and Guggenheim Securities, LLC |
|
|
|
3.1 |
|
Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.4 to Amendment No. 2 to Form S-1 filed on June 21, 2021) |
|
|
|
3.2 |
|
Amended and Restated Bylaws (incorporated by reference to Exhibit 3.5 to Amendment No. 2 to Form S-1 filed on June 21, 2021) |
|
|
|
3.3 |
|
Amended and Restated Certificate of Designation of Preferences, Rights and Limitations of the Series A Convertible Voting Preferred Stock (incorporated by reference to Exhibit 3.6 to Form 8-K filed on March 14, 2024. |
|
|
|
3.4 |
|
Certificate
of Designation of Preferences, Rights and Limitations of the Series B Convertible Preferred Stock (incorporated by reference to
Exhibit 3.1 to Form 8-K filed on March 14, 2024). |
|
|
|
3.5 |
|
Certificate of Amendment to Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to Form 8-K filed on June 26, 2024). |
| * | To the extent applicable, to be filed by an amendment or as
an exhibit to a document filed under the Securities Exchange Act of 1934, as amended, and incorporated by reference herein. |
Item 17. Undertakings.
(a) The undersigned registrant hereby undertakes:
(1) to file, during any period in which
offers or sales are being made, a post-effective amendment to this registration statement:
(i) to include any prospectus required by
Section 10(a)(3) of the Securities Act;
(ii) to reflect in the prospectus any facts
or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding
the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed
that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the
form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent
no more than 20% change in the maximum aggregate offering price set forth in the “Calculation of Filing Fee Table” table in
the effective registration statement; and
(iii) to include any material information
with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information
in the registration statement;
provided, however, that paragraphs (a)(1)(i),
(a)(1)(ii) and (a)(1)(iii) do not apply if the information required to be included in a post-effective amendment by those paragraphs
is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Exchange
Act that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule
424(b) that is part of the registration statement;
(2) that, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof;
(3) to remove from registration by means
of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering;
(4) That, for the purpose of determining liability
under the Securities Act of 1933 to any purchaser:
(i) Each prospectus filed by the registrant pursuant
to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and
included in the registration statement; and
(ii) Each prospectus required to be filed pursuant
to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant
to Rule 415(a)(l)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the Securities Act shall
be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used
after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided
in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be
a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus
relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof; provided, however,
that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated
or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as
to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration
statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective
date;
(5) That, for the purpose of determining liability
of the registrant under the Securities Act to any purchaser in the initial distribution of the securities, the undersigned registrant
undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless
of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means
of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer
or sell such securities to such purchaser:
(i) Any preliminary prospectus or prospectus
of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;
(ii) Any free writing prospectus relating to
the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;
(iii) The portion of any other free writing prospectus
relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf
of the undersigned registrant; and
(iv) Any other communication that is an offer
in the offering made by the undersigned registrant to the purchaser.
(6) That, for purposes of determining any liability
under the Securities Act, each filing of the registrant’s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange
Act (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Exchange Act)
that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(7) Insofar as indemnification for
liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant
pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director,
officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director,
officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.
(8) To file an application for the purpose of
determining the eligibility of the trustee to act under subsection (a) of Section 310 of the Trust Indenture Act of 1939 in accordance
with the rules and regulations prescribed by the Securities and Exchange Commission under Section 305(b)(2) of the Trust Indenture Act
of 1939.
SIGNATURES
Pursuant to the requirements
of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Los Altos, State of California, on November 13, 2024.
|
UNICYCIVE THERAPEUTICS, INC. |
|
|
|
By: |
/s/
Shalabh Gupta |
|
|
Shalabh Gupta |
|
|
Chief Executive Officer |
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and appoints Shalabh Gupta, his true and lawful attorney-in-fact
and agent with full power of substitution and re-substitution, for him and in his name, place and stead, in any and all capacities to
sign any or all amendments (including, without limitation, post-effective amendments) to this registration statement, any related registration
statement filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended, and any or all pre- or post-effective amendments
thereto, and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorney-in-fact and agent, full power and authority to do and perform each and every act and thing requisite
and necessary to be done in and about the premises, as fully for all intents and purposes as he or she might or could do in person, hereby
ratifying and confirming that said attorney-in-fact and agent, or any substitute or substitutes for him, may lawfully do or cause to
be done by virtue hereof.
Pursuant to the requirements
of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates
indicated.
Signature |
|
Title |
|
Date |
|
|
|
|
|
/s/ Shalabh
Gupta |
|
Chief Executive Officer, President and Chairman
of the Board of Directors |
|
November 13, 2024 |
Shalabh Gupta |
|
(Principal Executive Officer) |
|
|
|
|
|
|
|
/s/ John Townsend |
|
Chief Financial Officer |
|
November 13, 2024 |
John Townsend |
|
(Principal Financial and Accounting Officer) |
|
|
|
|
|
|
|
/s/ Saraswati
Kenkare-Mitra., Ph.D. |
|
Director |
|
November 13, 2024 |
Saraswati Kenkare-Mitra., Ph.D. |
|
|
|
|
|
|
|
|
|
/s/ Sandeep
Laumas, M.D. |
|
Director |
|
November 13, 2024 |
Sandeep Laumas, M.D.
|
|
|
|
|
/s/ Gaurav
Aggarwal, M.D. |
|
Director |
|
November 13, 2024 |
Gaurav Aggarwal, M.D. |
|
|
|
|
Exhibit 1.1
Execution Version
UNICYCIVE THERAPEUTICS, INC.
Shares of Common Stock
($0.001 par value per share)
SALES AGREEMENT
November 13, 2024
Guggenheim Securities, LLC
330 Madison Avenue
New York, New York 10017
Ladies and Gentlemen:
Unicycive Therapeutics, Inc., a Delaware corporation (the “Company”),
confirms its agreement (this “Agreement”) with Guggenheim Securities, LLC (the “Agent”),
as follows:
1. Issuance and Sale of Shares. The Company agrees that, from
time to time during the term of this Agreement, on the terms and subject to the conditions set forth herein, it may issue and sell through
the Agent up to $50,000,000 of shares of common stock, $0.001 par value per share, of the Company (the “Common Stock”),
subject to the limitations set forth in Section 5(c) (the “Placement Shares”). Notwithstanding anything to the
contrary contained herein, the parties hereto agree that compliance with the limitation set forth in this Section 1 on the aggregate gross
sales price of Placement Shares that may be issued and sold under this Agreement from time to time shall be the sole responsibility of
the Company, and that the Agent shall have no obligation in connection with such compliance. The issuance and sale of Placement Shares
through the Agent will be effected pursuant to the Registration Statement (as defined below) to be filed by the Company with the Securities
and Exchange Commission (the “Commission”) on November 13, 2024 and to be declared effective by the Commission,
although nothing in this Agreement shall be construed as requiring the Company to issue any Placement Shares.
The Company has prepared and will file, in accordance with the provisions
of the Securities Act of 1933, as amended, and the rules and regulations thereunder (collectively, the “Securities Act”),
with the Commission a registration statement on Form S-3, including (a) a base prospectus, relating to certain securities, including the
Common Stock, to be issued from time to time by the Company, and which incorporates by reference documents that the Company has filed
or will file in accordance with the provisions of the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder
(collectively, the “Exchange Act”), and (b) a prospectus supplement specifically relating to the Placement Shares
to be issued from time to time pursuant to this Agreement (the “Prospectus Supplement”) to the base prospectus
included as part of such registration statement. The Company will furnish to the Agent, for use by the Agent, copies of the base prospectus
included as part of such registration statement at the time it becomes effective, as supplemented by the Prospectus Supplement. Except
where the context otherwise requires, such registration statement, including all documents filed as part thereof or incorporated by reference
therein, and including any information contained in a Prospectus (as defined below) subsequently filed with the Commission pursuant to
Rule 424(b) under the Securities Act or deemed to be a part of such registration statement pursuant to Rule 430B or Rule 462(b) under
the Securities Act, is herein called the “Registration Statement.” The base prospectus, including all documents
incorporated therein by reference, included in the Registration Statement, as it may be supplemented by the Prospectus Supplement, in
the form in which such prospectus and/or Prospectus Supplement have most recently been filed by the Company with the Commission pursuant
to Rule 424(b) under the Securities Act, together with any “issuer free writing prospectus” (as used herein, as defined in
Rule 433 under the Securities Act (“Rule 433”)), relating to the Placement Shares that (i) is required to be
filed with the Commission by the Company or (ii) is exempt from filing pursuant to Rule 433(d)(5)(i), in each case, in the form filed
or required to be filed with the Commission or, if not required to be filed, in the form retained in the Company’s records pursuant
to Rule 433(g), is herein called the “Prospectus.”
Any reference herein to the Registration Statement, the Prospectus
Supplement, the Prospectus or any issuer free writing prospectus shall be deemed to refer to and include the documents, if any, that are
or are deemed to be incorporated by reference therein (the “Incorporated Documents”), including, unless the
context otherwise requires, the documents, if any, filed as exhibits to such Incorporated Documents. Any reference herein to the terms
“amend,” “amendment” or “supplement” with respect to the Registration Statement, the Prospectus Supplement,
the Prospectus or any issuer free writing prospectus shall be deemed to refer to and include the filing of any document under the Exchange
Act on or after the most-recent effective date of the Registration Statement, or the respective dates of the Prospectus Supplement, Prospectus
or such issuer free writing prospectus, as the case may be, and incorporated therein by reference. For purposes of this Agreement, all
references to the Registration Statement, the Prospectus or any amendment or supplement thereto shall be deemed to include the most recent
copy filed with the Commission pursuant to its Electronic Data Gathering Analysis and Retrieval System or, if applicable, the Interactive
Data Electronic Application system when used by the Commission (collectively, “EDGAR”).
2. Placements. Each time that the Company wishes to issue and
sell any Placement Shares through the Agent hereunder (each, a “Placement”), it will notify the Agent by email
notice (or other method mutually agreed to in writing by the parties) (each such notice, a “Placement Notice”)
containing the parameters in accordance with which it desires such Placement Shares to be sold, which at a minimum shall include the maximum
number or amount of Placement Shares to be sold, the time period during which sales are requested to be made, any limitation on the number
or amount of Placement Shares that may be sold in any one Trading Day (as defined in Section 3) and any minimum price below which sales
may not be made, a form of which containing such minimum sales parameters is attached hereto as Schedule 1. The Placement
Notice must originate from one of the individuals authorized to act on behalf of the Company and set forth on Schedule 2
(with a copy to each of the other individuals from the Company listed on such Schedule 2), and shall be addressed to each
of the recipients from the Agent set forth on Schedule 2, as such Schedule 2 may be updated by either party
from time to time by sending a written notice containing a revised Schedule 2 to the other party in the manner provided
in Section 12 (including by email correspondence to each of the individuals of the Company set forth on Schedule 2, if receipt
of such correspondence is actually acknowledged by any of the individuals to whom the notice is sent, other than via auto-reply). The
Placement Notice shall be effective upon receipt by the Agent unless and until (i) in accordance with the notice requirements set forth
in Section 4, the Agent declines to accept the terms contained therein for any reason, in its sole discretion, within one Trading Day
of the date the Agent receives the Placement Notice, (ii) in accordance with the notice requirements set forth in Section 4, the Agent
suspends sales under the Placement Notice for any reason in its sole discretion, (iii) the entire amount of the Placement Shares has been
sold pursuant to this Agreement, (iv) in accordance with the notice requirements set forth in Section 4, the Company suspends sales under
or terminates the Placement Notice for any reason in its sole discretion, (v) the Company issues a subsequent Placement Notice and explicitly
indicates that its parameters supersede those contained in the earlier dated Placement Notice or (vi) this Agreement has been terminated
pursuant to the provisions of Section 11. The amount of any discount, commission or other compensation to be paid by the Company to the
Agent in connection with the sale of the Placement Shares effected through the Agent shall be calculated in accordance with the terms
set forth in Schedule 3. It is expressly acknowledged and agreed that neither the Company nor the Agent will have any obligation
whatsoever with respect to a Placement or any Placement Shares unless and until the Company delivers a Placement Notice to the Agent and
the Agent does not decline such Placement Notice pursuant to the terms set forth above, and then only upon the terms specified therein
and herein. In the event of a conflict between the terms of this Agreement and the terms of a Placement Notice, the terms of the Placement
Notice will control with respect to the matters covered thereby.
3. Sale of Placement Shares by the Agent. On the basis of the
representations and warranties herein contained and subject to the terms and conditions herein set forth, including Section 5(c), upon
the Agent’s acceptance of the terms of a Placement Notice as provided in Section 2, and unless the sale of the Placement Shares
described therein has been declined, suspended or otherwise terminated in accordance with the terms of this Agreement, the Agent, for
the period specified in the Placement Notice, will use its commercially reasonable efforts consistent with its normal trading and sales
practices and applicable state and federal laws, rules and regulations and the rules of the Nasdaq Capital Market (“Nasdaq”)
to sell such Placement Shares up to the number or amount specified in, and otherwise in accordance with the terms of, such Placement Notice.
The Agent will provide written confirmation to the Company (including by email correspondence to each of the individuals of the Company
set forth on Schedule 2, if receipt of such correspondence is actually acknowledged by any of the individuals to whom the
notice is sent, other than via auto-reply) no later than the opening of the Trading Day (as defined below) immediately following the Trading
Day on which it has made sales of Placement Shares hereunder setting forth the number or amount of Placement Shares sold on such Trading
Day, the volume-weighted average price of the Placement Shares sold and the Net Proceeds (as defined below) payable to the Company. Unless
otherwise specified by the Company in a Placement Notice, the Agent may sell Placement Shares by any method permitted by law deemed to
be an “at the market offering” as defined in Rule 415 of the Securities Act, including sales made directly on or through Nasdaq,
on or through any other existing trading market for the Common Stock or to or through a market maker. If expressly authorized by the Company
(including in a Placement Notice), the Agent may also sell Placement Shares in negotiated transactions. Notwithstanding the provisions
of Section 6(tt), except as may be otherwise agreed by the Company and the Agent, the Agent shall not purchase Placement Shares on a principal
basis pursuant to this Agreement unless the Company and the Agent enter into a separate written agreement setting forth the terms of such
sale. The Company acknowledges and agrees that (i) there can be no assurance that the Agent will be successful in selling Placement Shares,
(ii) the Agent will incur no liability or obligation to the Company or any other person or entity if it does not sell Placement Shares
for any reason other than a failure by the Agent to use its commercially reasonable efforts consistent with its normal trading and sales
practices and applicable state and federal laws, rules and regulations and the rules of Nasdaq to sell such Placement Shares as required
under this Agreement and (iii) the Agent shall be under no obligation to purchase Placement Shares on a principal basis pursuant to this
Agreement unless the Company and the Agent enter into a separate written agreement setting forth the terms of such sale. For the purposes
hereof, “Trading Day” means any day on which the Common Stock is purchased and sold on Nasdaq. In the event
the Company engages the Agent for a sale of Placement Shares that would constitute a “block” within the meaning of Rule 10b-18(a)(5)
under the Exchange Act (a “Block Sale”), the Company will provide the Agent, at the Agent’s request and
upon reasonable advance notice to the Company, on or prior to the Settlement Date (as defined below), the opinions of counsel, comfort
letter and officers’ certificates set forth in Section 7 hereof, each dated the Settlement Date, and such other documents and information
as the Agent shall reasonably request.
4. Suspension of Sales.
(a) The Company or the Agent may, upon notice to the other party in
writing (including by email correspondence to each of the individuals of the other party set forth on Schedule 2, if receipt
of such correspondence is actually acknowledged by any of the individuals to whom the notice is sent, other than via auto-reply) or by
telephone (confirmed immediately by email correspondence to each of the individuals of the other party set forth on Schedule 2),
suspend any sale of Placement Shares; provided, however, that such suspension shall not affect or impair either party’s
obligations with respect to any Placement Shares sold hereunder prior to the receipt of such notice. Each of the parties agrees that no
such notice under this Section 4 shall be effective against the other party unless notice is sent by one of the individuals named on Schedule
2 hereto to the other party in writing (including by email correspondence to each of the individuals of the other party set forth
on Schedule 2, if receipt of such correspondence is actually acknowledged by any of the individuals to whom the notice is
sent, other than via auto-reply).
(b) Notwithstanding any other provision of this Agreement, during any
period in which the Company is in possession of material non-public information, the Company and the Agent agree that (i) the Company
shall not request the sale of any Placement Shares and shall suspend or cancel any effective Placement Notices instructing the Agent to
make any sales and (ii) the Agent shall not be obligated to sell or offer to sell any Placement Shares.
5. Settlement and Delivery of the Placement Shares.
(a) Settlement of Placement Shares. Unless otherwise specified
in the applicable Placement Notice, settlement for sales of Placement Shares will occur on the first Trading Day (or such earlier day
as is industry practice or as is required for regular-way trading) following the date on which such sales are made (each, a “Settlement
Date”). The amount of proceeds to be delivered to the Company on a Settlement Date against receipt of the Placement Shares
sold (the “Net Proceeds”) will be equal to the aggregate gross sales price received by the Agent at which such
Placement Shares were sold, after deduction of (i) the Agent’s commission, discount or other compensation for such sales payable
by the Company pursuant to Section 2 hereof, (ii) any other amounts due and payable by the Company to the Agent hereunder pursuant to
Section 7(g) hereof and (iii) any transaction fees imposed by any governmental or self-regulatory organization in respect of such sales.
(b) Delivery of Placement Shares. On or before each Settlement
Date, against payment of the Net Proceeds, the Company will issue the Placement Shares being sold on such date and will, or will cause
its transfer agent to, electronically transfer such Placement Shares by crediting the Agent’s or its designee’s account (provided
the Agent shall have given the Company written notice of such designee prior to the Settlement Date) at The Depository Trust Company through
its Deposit and Withdrawal at Custodian System (“DWAC”) or by such other means of delivery as may be mutually
agreed upon by the parties hereto, which in all cases shall be duly authorized, freely tradeable, transferable, registered shares of Common
Stock in good deliverable form. On each Settlement Date, the Agent will deliver the related Net Proceeds in same day funds to an account
designated by the Company on or prior to the Settlement Date. The Agent shall be responsible for providing DWAC instructions or other
instructions for delivery by other means with regard to the transfer of the Placement Shares being sold. In addition to and in no way
limiting the rights and obligations set forth in Section 9(a) hereto, the Company agrees that if the Company or its transfer agent (if
applicable), defaults in its obligation to deliver duly authorized, freely tradeable, transferable, registered Placement Shares in good
deliverable form by 2:30 P.M., New York City time, on a Settlement Date (other than as a result of a failure by the Agent to provide instructions
for delivery), the Company will (i) take all necessary action to cause the full amount of any Net Proceeds that were delivered to the
Company’s account with respect to such settlement, together with any costs incurred by the Agent and/or its clearing firm in connection
with recovering such Net Proceeds, to be immediately returned to the Agent or its clearing firm no later than 5:00 P.M., New York City
time, on such Settlement Date, by wire transfer of immediately available funds to an account designated by the Agent or its clearing firm,
(ii) indemnify and hold the Agent and its clearing firm harmless against any loss, claim, damage, or expense (including reasonable legal
fees and expenses), as incurred, arising out of or in connection with such default by the Company or its transfer agent (if applicable)
(excluding any amounts paid pursuant to subclause (b)(i) above) and (iii) pay to the Agent any commission, discount or other compensation
to which it would otherwise have been entitled absent such default. Certificates for the Placement Shares, if any, shall be in such denominations
and registered in such names as the Agent may request in writing one Business Day (as defined below) before the applicable Settlement
Date. Certificates for the Placement Shares, if any, will be made available by the Company for examination and packaging by the Agent
in New York City not later than 12:00 P.M., New York City time, on the Business Day prior to the applicable Settlement Date; provided,
that the Agent shall have provided the Company with the requested denominations and names for such certificates.
(c) Limitations on Offering Size. Under no circumstances shall
the Company cause or request the offer or sale of any Placement Shares if, after giving effect to the sale of such Placement Shares, the
aggregate number or gross sales proceeds of Placement Shares sold pursuant to this Agreement would exceed the lesser of: (i) the number
or dollar amount of shares of Common Stock registered pursuant to, and available for offer and sale under, the Registration Statement
pursuant to which the offering of Placement Shares is being made, (ii) the number of authorized but unissued shares of Common Stock of
the Company (less shares of Common Stock issuable upon exercise, conversion or exchange of any outstanding securities of the Company or
otherwise reserved from the Company’s authorized capital stock), (iii) the number or dollar amount of shares of Common Stock permitted
to be offered and sold by the Company under Form S-3 (including General Instruction I.B.6. thereof, if such instruction is applicable),
(iv) the number or dollar amount of shares of Common Stock that the Company’s board of directors or a duly authorized committee
thereof or authorized executive officers of the Company are authorized to issue and sell from time to time, and notified to the Agent
in writing, or (v) the dollar amount of shares of Common Stock for which the Company has filed the Prospectus Supplement. Under no circumstances
shall the Company cause or request the offer or sale of any Placement Shares pursuant to this Agreement at a price lower than the minimum
price authorized from time to time by the Company’s board of directors or a duly authorized committee thereof or authorized executive
officers of the Company, and notified to the Agent in writing. Notwithstanding anything to the contrary contained herein, the parties
hereto acknowledge and agree that compliance with the limitations set forth in this Section 5(c) on the number or dollar amount of Placement
Shares that may be issued and sold under this Agreement from time to time shall be the sole responsibility of the Company, and that the
Agent shall have no obligation in connection with such compliance.
6. Representations and Warranties of the Company. The Company
represents and warrants to, and agrees with, the Agent that, unless such representation or warranty specifies a different time, as of
the date of this Agreement, and as of (i) each Representation Date (as defined in Section 7(m)), (ii) each date on which a Placement Notice
is given, (iii) the date and time of each sale of any Placement Shares pursuant to this Agreement and (iv) each Settlement Date (each
such time or date referred to in clauses (i) through (iv), an “Applicable Time”):
(a) The Company and the transactions contemplated by this Agreement
meet the requirements for and comply with the conditions for the use of Form S-3 (including General Instructions I.A and I.B.1.) under
the Securities Act. The Registration Statement will be filed with the Commission and will be declared effective by the Commission under
the Securities Act prior to the issuance of any Placement Notices by the Company. At the time the Registration Statement originally became
effective and at the time the Company’s most recent Annual Report on Form 10-K was filed with the Commission, the Company met the
then-applicable requirements for use of Form S-3 (including General Instructions I.A and I.B.1.) under the Securities Act. The Registration
Statement meets, and the offering and sale of Placement Shares as contemplated hereby comply with, the requirements of Rule 415(a)(1)(x)
under the Securities Act. The Agent is named as the agent engaged by the Company in the section entitled “Plan of Distribution”
in the Prospectus Supplement. The Company has not received, and has no notice from the Commission of, any notice pursuant to Rule 401(g)(1)
under the Securities Act objecting to the use of the shelf registration statement form. No stop order of the Commission preventing or
suspending the use of the base prospectus, the Prospectus Supplement or the Prospectus, or the effectiveness of the Registration Statement,
has been issued, and no proceedings for such purpose are pending before or, to the knowledge of the Company, threatened by the Commission.
At the time of the initial filing of the Registration Statement, the Company paid the required Commission filing fees relating to the
securities covered by the Registration Statement, including the Placement Shares that may be sold pursuant to this Agreement, in accordance
with Rule 457(o) under the Securities Act. Copies of the Registration Statement, the Prospectus, any such amendments or supplements to
any of the foregoing and all Incorporated Documents that were filed with the Commission on or prior to the date of this Agreement have
been delivered, or are available through EDGAR, to the Agent and its counsel.
(b) Each of the Registration Statement and any post-effective amendment
thereto, at the time it became or becomes effective, at each deemed effective date with respect to the Agent pursuant to Rule 430B(f)(2)
under the Securities Act and as of each Applicable Time, complied, complies and will comply in all material respects with the requirements
of the Securities Act and did not, does not and will not contain any untrue statement of a material fact or omit to state a material fact
required to be stated therein or necessary to make the statements therein not misleading, except that the representations and warranties
set forth in this sentence do not apply to Agent’s Information (as defined below). The Prospectus and any amendment or supplement
thereto, when so filed with the Commission under Rule 424(b) under the Securities Act, complied, complies and as of each Applicable Time
will comply in all material respects with the requirements of the Securities Act, and each Prospectus Supplement, Prospectus or issuer
free writing prospectus (or any amendments or supplements to any of the foregoing) furnished to the Agent for use in connection with the
offering of the Placement Shares was identical to the electronically transmitted copies thereof filed with the Commission pursuant to
EDGAR, except to the extent permitted by Regulation S-T. Neither the Prospectus nor any amendment or supplement thereto, as of its date
and as of each Applicable Time, included, includes or will include an untrue statement of a material fact or omitted, omits or will omit
to state a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made,
not misleading, except that the representations and warranties set forth in this sentence do not apply to Agent’s Information. Each
Incorporated Document heretofore filed, when it was filed (or, if any amendment with respect to any such document was filed, when such
amendment was filed), conformed in all material respects with the requirements of the Exchange Act and were filed on a timely basis with
the Commission, and any further Incorporated Documents so filed and incorporated after the date of this Agreement will be filed on a timely
basis and, when so filed, will conform in all material respects with the requirements of the Exchange Act; no such Incorporated Document
when it was filed (or, if an amendment with respect to any such document was filed, when such amendment was filed), contained an untrue
statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements
therein, in the light of the circumstances under which they were made, not misleading; and no such Incorporated Document, when it is filed,
will contain an untrue statement of a material fact or will omit to state a material fact required to be stated therein or necessary in
order to make the statements therein, in light of the circumstances under which they were made, not misleading.
(c) (i) At the time of filing the Registration Statement and (ii) at
the time of the execution of this Agreement (with such date being used as the determination date for purposes of this clause (ii)), the
Company was not and is not an “ineligible issuer” (as defined in Rule 405), without taking account of any determination by
the Commission pursuant to Rule 405 that it is not necessary that the Company be considered an ineligible issuer.
(d) From the time of the initial filing of the Company’s first
registration statement with the Commission through the date hereof, the Company has been and is an “emerging growth company,”
as defined in Section 2(a) of the Securities Act (an “Emerging Growth Company”).
(e) Each issuer free writing prospectus, as of its issue date and as
of each Applicable Time, did not, does not and will not include any information that conflicted, conflicts or will conflict with the information
contained in the Registration Statement or the Prospectus, including any Incorporated Document deemed to be a part thereof that has not
been superseded or modified. Each issuer free writing prospectus that the Company has filed, or is required to file, pursuant to Rule
433 or that was prepared by or on behalf of or used by the Company complies or will comply in all material respects with the requirements
of the Securities Act.
(f) The Company has not distributed and, prior to the later to occur
of each Settlement Date and completion of the Agent’s distribution of the Placement Shares under this Agreement, will not distribute
any offering material in connection with the offering and sale of the Placement Shares other than the Registration Statement, the Prospectus
or any Permitted Free Writing Prospectus (as defined below).
(g) The interactive data in eXtensible Business Reporting Language
included or incorporated by reference in the Registration Statement and the Prospectus fairly presents the information called for in all
material respects and has been prepared in accordance with the Commission’s rules and guidelines applicable thereto.
(h) The Company is subject to and in compliance in all material respects
with the reporting requirements of Section 13 or Section 15(d) of the Exchange Act. The Common Stock is registered pursuant to Section
12(b) of the Exchange Act and is listed on Nasdaq, and the Company has taken no action designed to, or reasonably likely to have the effect
of, terminating the registration of the Common Stock under the Exchange Act or delisting the Common Stock from Nasdaq, except as disclosed
in the Registration Statement, the Prospectus Supplement and the Prospectus nor has the Company received any notification that the Commission
or Nasdaq is contemplating terminating such registration or listing, except as disclosed in the Registration Statement or Prospectus.
Except as disclosed in the Registration Statement, the Prospectus Supplement and the Prospectus, the Company is in compliance with the
current listing standards of Nasdaq in all material respects. The Company has filed a Notification of Listing of Additional Shares with
Nasdaq with respect to the Placement Shares.
(i) No person (as such term is defined in Rule 1-02 of Regulation S-X
promulgated under the Securities Act) has the right to act as an underwriter or as a financial advisor to the Company in connection with
the offer and sale of the Placement Shares hereunder, whether as a result of the filing or effectiveness of the Registration Statement
or the sale of the Placement Shares as contemplated hereby or otherwise. Except for the Agent, there is no broker, finder or other party
that is entitled to receive from the Company any brokerage or finder’s fee or other fee or commission as a result of any transactions
contemplated by this Agreement.
(j) The Company has been duly incorporated and is validly existing
as a corporation in good standing under the laws of the State of Delaware, with full corporate power and authority to acquire, own, lease
and operate its properties, and to lease the same to others, and to conduct its business as described in the Registration Statement and
the Prospectus and to enter into and perform its obligations under this Agreement. The Company is duly qualified to transact business
as a foreign corporation and is in good standing in the State of California and under the laws of each other jurisdiction that requires
such qualification, whether by reason of the ownership or leasing of property or the conduct of business, except to the extent that the
failure to be so qualified or in good standing could not reasonably be expected, individually or in the aggregate, to have a Material
Adverse Effect on the condition (financial or otherwise), earnings, results of operations, business, properties, operations, assets, liabilities
or prospects of the Company, taken as a whole, whether or not arising from transactions in the ordinary course of business (a “Material
Adverse Effect”).
(k) The Company does not have any “subsidiaries” (for purposes
of this Agreement, as defined in Rule 405 under the Securities Act).
(l) The Company has the authorized and outstanding capitalization as
set forth in the Registration Statement and Prospectus, as of the dates referred to therein (subject, in each case, to the issuance of
Placement Shares under this Agreement, the issuance of shares of Common Stock upon exercise of share options and warrants disclosed as
outstanding in the Registration Statement and the Prospectus and the grant of options under existing share option plans described in the
Registration Statement and the Prospectus). The Common Stock conforms in all material respects to the description thereof contained in
the Registration Statement and the Prospectus, including under the heading “Description of Capital Stock.” All of the issued
and outstanding share capital or other equity or ownership interest of the Company (including the Common Stock) have been duly authorized
and validly issued and is fully paid and nonassessable, have been issued in compliance with all federal, state and local securities laws
and are free and clear of any security interest, mortgage, pledge, lien, encumbrance or adverse claim. None of the outstanding shares
of capital stock of the Company were issued in violation of any preemptive rights, rights of first refusal or other similar rights to
subscribe for or purchase securities of the Company. There are no authorized or outstanding options, warrants, preemptive rights, rights
of first refusal or other rights to purchase or subscribe for, or equity or debt securities convertible into or exchangeable or exercisable
for, any share capital of the Company other than those described in the Registration Statement and the Prospectus. The descriptions of
the Company’s equity incentive plan, stock option plans and other stock plans or arrangements described in the Prospectus and in
effect as of the date hereof (collectively, the “Stock Plans”) and the options or other rights granted thereunder,
set forth in the Registration Statement and the Prospectus accurately and fairly present, in all material respects, the information required
to be shown with respect to such Stock Plans and the options or other rights granted thereunder.
(m) The Placement Shares have been duly authorized for issuance and
sale pursuant to this Agreement and, when issued and delivered by the Company against payment therefor pursuant to this Agreement, will
be validly issued, fully paid and nonassessable and will conform in all material respects to the description thereof contained in the
Prospectus. The issuance and sale of the Placement Shares as contemplated hereby shall not be subject to any preemptive rights, rights
of first refusal or other similar rights to subscribe for or purchase the Placement Shares. When issued and delivered by the Company against
payment therefor pursuant to this Agreement, the purchasers of the Placement Shares issued and sold hereunder will acquire good, marketable
and valid title to such Placement Shares, free and clear of all pledges, liens, security interests, charges, claims or encumbrances. The
issuance and sale of the Placement Shares as contemplated hereby will not cause any holder of any share capital, securities convertible
into or exchangeable or exercisable for share capital or options, warrants or other rights to purchase share capital or any other securities
of the Company to have any right to acquire any preferred shares of the Company. There are no restrictions upon the voting or transfer
of the Common Stock under the Company’s amended and restated certificate of incorporation or amended and restated bylaws or any
agreement or other instrument to which the Company is a party or otherwise filed as an exhibit to the Registration Statement.
(n) There are no contracts or documents which are required to be described
in the Registration Statement or the Prospectus or to be filed as exhibits to the Registration Statement which have not been so described
and filed as required.
(o) This Agreement has been duly and validly authorized, executed and
delivered by the Company and constitutes a valid and legally binding obligation of the Company, enforceable against the Company in accordance
with its terms, except as enforceability, including rights of indemnification, may be limited by bankruptcy, insolvency, fraudulent conveyance,
reorganization, moratorium and other similar laws relating to or affecting creditors’ rights generally and by general principles
of equity.
(p) The Company is not and, after giving effect to the offering and
sale of the Placement Shares and the application of the proceeds thereof as described in the Prospectus, will not be an “investment
company” as defined in the Investment Company Act of 1940, as amended.
(q) No consent, approval, license, permit, qualification, authorization
or other order or decree of, or registration or filing with, any court or other governmental, taxing or regulatory authority or agency,
is required for the Company’s execution, delivery and performance of this Agreement or consummation of the transactions contemplated
hereby or by the Registration Statement and the Prospectus (including the issuance and sale of the Placement Shares hereunder), except
such as have been already obtained or made or as may be required under the Securities Act, applicable state securities or Blue Sky laws,
applicable rules of Nasdaq, or Rule 5110 of the Financial Industry Regulatory Authority, Inc. (“FINRA”).
(r) Neither the execution and delivery by the Company of, nor the performance
of the Company of its obligations under, this Agreement will conflict with, result in a breach or violation of, or result in the creation
or imposition of any lien, charge or encumbrance upon any property or assets of the Company pursuant to: (i) the certificate or articles
of incorporation, charter, bylaws, articles of association, limited liability company agreement, certificate or agreement of limited or
general partnership or other similar organizational documents, as the case may be, of such entity, (ii) the terms of any indenture, contract,
license, lease, mortgage, deed of trust, note agreement, agreement or other instrument, obligation, condition, covenant or instrument
to which it is a party or bound or to which its property or assets is subject or (iii) any statute, law, rule, regulation, judgment, order
or decree applicable to the Company of any court, regulatory body, administrative agency, governmental body, arbitrator or other authority
having jurisdiction over the Company, or any of its respective properties or assets, as applicable, except, in the case of clauses (ii)
and (iii) above, for any such conflict, breach, violation or default that would not, individually or in the aggregate, have a Material
Adverse Effect.
(s) Subsequent to the respective dates as of which information is given
in the Registration Statement and the Prospectus: (i) there has been no material adverse change, or any development that could reasonably
be expected to result in a material adverse change, in the condition (financial or otherwise), earnings, results of operations, business,
properties, operations, assets, liabilities or prospects of the Company, taken as a whole, whether or not arising from transactions in
the ordinary course of business; (ii) the Company has not (A) incurred any material liability or obligation, indirect, direct or contingent,
including without limitation any losses or interference with its business from fire, explosion, flood, earthquakes, accident or other
calamity, whether or not covered by insurance, or from any strike, labor dispute or court or governmental action, order or decree, that
are material, individually or in the aggregate, to the Company, considered as one entity, or (B) entered into any material transactions
not in the ordinary course of business; and (iii) there has not been any material decrease in the share capital or any material increase
in any short-term or long-term indebtedness of the Company and there has been no dividend or distribution of any kind declared, paid or
made by the Company or, except for dividends paid to the Company, on any class of shares, or any repurchase or redemption by the Company
of any class of shares.
(t) There are no persons (as such term is defined in Rule 1-02 of Regulation
S-X promulgated under the Securities Act) with registration or other similar rights to have any equity or debt securities of the Company
registered for sale under the Registration Statement or included in the offering contemplated by this Agreement, except for such rights
as have been duly waived in a writing previously furnished to the Agent.
(u) The financial statements included or incorporated by reference
in the Registration Statement and the Prospectus, together with the related notes and schedules, present fairly, in all material respects,
the consolidated financial position of the Company as of the dates indicated and the consolidated results of operations, cash flows and
changes in stockholders’ equity of the Company for the periods specified and have been prepared in compliance with the requirements
of the Securities Act and Exchange Act and in conformity with United States generally accepted accounting principles (“GAAP”)
applied on a consistent basis during the periods involved, except as may be expressly stated in the related notes thereto. To the extent
applicable, any pro forma financial statements, information or data included or incorporated by reference in the Registration Statement
and the Prospectus comply with the requirements of Regulation S-X of the Securities Act, including, without limitation, Article 11 thereof,
fairly present the information set forth herein, and the assumptions used in the preparation of such pro forma financial statements and
data are reasonable, the pro forma adjustments used therein are appropriate to give effect to the circumstances referred to therein and
the pro forma adjustments have been properly applied to the historical amounts in the compilation of those statements and data. The other
financial data set forth or incorporated by reference in the Registration Statement and the Prospectus is accurately and fairly presented
and prepared on a basis consistent with the financial statements and books and records of the Company. There are no financial statements
(historical or pro forma) that are required to be included or incorporated by reference in the Registration Statement or the Prospectus
that are not included or incorporated by reference therein as required. The Company does not have any material liabilities or obligations,
direct or contingent (including any off-balance sheet obligations or any “variable interest entities” as that term is used
in Accounting Standards Codification Paragraph 810-10-25-20, not disclosed in the Registration Statement and the Prospectus. All disclosures
contained in the Registration Statement or the Prospectus that contain “non-GAAP financial measures” (as such term is defined
by the rules and regulations of the Commission) comply, in all material respects, with Regulation G under the Exchange Act and Item 10
of Regulation S-K under the Securities Act, to the extent applicable. The statistical, industry-related and market-related data included
or incorporated by reference in the Registration Statement and the Prospectus were obtained or derived from sources which the Company
reasonably and in good faith believes are reliable and accurate, such data agree with the sources from which they are derived, and the
Company has obtained the written consent to the use of such data from such sources to the extent required. To the Company’s knowledge,
no person who has been suspended or barred from being associated with a registered public accounting firm, or who has failed to comply
with any sanction pursuant to Rule 5300 promulgated by the Public Company Accounting Oversight Board (“PCAOB”),
has participated in or otherwise aided the preparation of, or audited, the financial statements, supporting schedules or other financial
data filed with the Commission as a part of the Registration Statement and the Prospectus.
(v) There are no actions, suits, claims, investigations or proceedings
pending or, to the Company’s knowledge, threatened to which the Company is or would be a party, or of which any of the respective
properties or assets of the Company is or would be subject, at law or in equity, before any court or arbitral body or by or before any
federal, state, local or foreign governmental or regulatory commission, board, body, authority or agency, that (i) are required to be
described in the Registration Statement or the Prospectus and are not so described, (ii) could reasonably be expected to have a Material
Adverse Effect on the ability of the Company to perform its obligations under this Agreement or on the consummation of any of the transactions
contemplated hereby or (iii) could reasonably be expected to have a Material Adverse Effect. The aggregate of all pending legal or governmental
proceedings to which the Company is a party or of which any of their respective properties or assets is the subject which are not described
in the Prospectus, including ordinary routine litigation incidental to the Company’s business, could not reasonably be expected
to (A) result in a Material Adverse Effect or (B) have a Material Adverse Effect on the ability of the Company to perform its obligations
under this Agreement or the consummation of any of the transactions contemplated hereby.
(w) The Company owns or leases all such real properties as are necessary
to the conduct of its operations as presently conducted in all material respects.
(x) The Company is not in violation or default of (i) any provision
of its certificate or articles of incorporation, charter, bylaws, articles of association, limited liability company agreement, certificate
or agreement of limited or general partnership, or other similar organizational documents, as the case may be, of such entity, (ii) the
terms of any indenture, contract, lease, mortgage, deed of trust, note agreement, loan agreement or other agreement, obligation, condition,
covenant or instrument to which it is a party or bound or to which its property or assets is subject, or (iii) any statute, law, rule,
regulation, judgment, order or decree of any court, regulatory body, administrative agency, governmental body, arbitrator or other authority
having jurisdiction over the Company or any of its respective properties or assets, as applicable, except, in the case of clauses (ii)
and (iii) above, for any such default or violation that would not, individually or in the aggregate, have a Material Adverse Effect.
(y) Each of CBIZ CPAs P.C., which previously served as the Company’s
independent registered public accounting firm until August 14, 2023, and Grassi & Co, CPAs, P.C. which was appointed to serve as the
Company’s independent registered public accounting firm on August 28, 2023, whose reports on the consolidated financial statements
of the Company are filed with the Commission as part of the Company’s most recent annual report on Form 10-K filed with the Commission
and incorporated by reference in the Registration Statement and the Prospectus, is (i) an independent registered public accounting firm
as required by the Securities Act, the Exchange Act and the rules of the PCAOB, (ii) in compliance with the applicable requirements relating
to the qualification of accountants under Rule 2-01 of Regulation S-X under the Securities Act and (iii) a registered public accounting
firm as defined by the PCAOB whose registration has not been suspended or revoked and who has not requested such registration to be withdrawn.
Each of CBIZ CPAs P.C. and Grassi & Co, CPAs, P.C. has not been engaged by the Company to perform any “prohibited activities”
or provided to the Company any “non-audit services” (as defined in Section 10A of the Exchange Act).
(z) There are no transfer taxes or other similar fees or charges under
federal law, the laws of any state, any foreign law, or any political subdivision thereof, required to be paid in connection with the
execution and delivery of this Agreement or the issuance by the Company or sale by the Company of the Placement Shares.
(aa) All United States federal income tax returns of the Company required
by law to be filed have been filed or extensions thereof have been requested, and all taxes shown by such returns or otherwise assessed,
which are due and payable, have been paid, except assessments that are being contested in good faith and as to which adequate reserves
have been provided under GAAP, except as otherwise disclosed in the Registration Statement and Prospectus, or where the failure to pay
or file any such taxes would not have a Material Adverse Effect. The Company has no knowledge of any material tax deficiency which has
been or is likely to be threatened or asserted against the Company. The Company has filed all foreign, state, provincial, local or other
tax returns that are required to have been filed pursuant to applicable foreign, state, provincial, local or other law except insofar
as the failure to file such returns would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse
Effect, and paid all taxes due pursuant to such returns or pursuant to any assessment received by the Company, except for such taxes,
if any, as are being contested in good faith and as to which adequate reserves have been provided and except for such taxes or assessments
the nonpayment of which would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse Effect. The
charges, accruals and reserves on the books of the Company in respect of any income or other tax liability for any years not finally determined
are adequate to meet any assessments or re-assessments for additional tax for any years not finally determined, except to the extent of
any inadequacy that would not reasonably be expected to result in a Material Adverse Effect. All material taxes which the Company are
required by law to withhold or to collect for payment have been duly withheld and collected and have been paid to the appropriate governmental
authority or agency or have been accrued, reserved against and entered on the books of the Company.
(bb) No labor dispute with the employees of the Company exists or,
to the Company’s knowledge, is threatened or imminent, and the Company is not aware of any existing, threatened or imminent labor
disturbance by the employees of any of its principal suppliers, manufacturers, contractors or customers, in each case that would have
a Material Adverse Effect.
(cc) The Company is insured by recognized and reputable institutions
with policies in such amounts and with such deductibles and covering such risks as are generally deemed adequate and customary for their
businesses including, but not limited to, policies covering real and personal property owned or leased by the Company against theft, damage,
destruction, acts of vandalism and policies covering the Company for clinical trial liability claims. The Company has no reason to believe
that it will not be able (i) to renew its existing insurance coverage as and when such policies expire or (ii) to obtain comparable coverage
from similar institutions as may be necessary or appropriate to conduct its business as now conducted and at a cost that could not reasonably
be expected to have a Material Adverse Effect. The Company has not been denied any material insurance coverage which it has sought or
for which it has applied.
(dd) The Company has good and marketable title in fee simple to all
real property owned by them and good and marketable title to all personal property owned by them that is material to their business (except
with respect to intellectual property, which is addressed exclusively in Section 6(pp), Section 6(qq) and Section 6(ggg) below), in each
case free and clear of all liens, encumbrances and defects except such as do not materially affect the value of such property and do not
interfere with the use made and proposed to be made of such property by the Company; and any real property and buildings held under lease
by the Company are held by them under valid, subsisting and enforceable leases (subject to the effects of (A) bankruptcy, insolvency,
fraudulent conveyance, fraudulent transfer, reorganization, moratorium or other similar laws relating to or affecting the rights or remedies
of creditors generally; (B) the application of general principles of equity (including, without limitation, concepts of materiality, reasonableness,
good faith and fair dealing, regardless of whether enforcement is considered in proceedings at law or in equity); and (C) applicable law
and public policy with respect to rights to indemnity and contribution) with such exceptions as are not material and do not interfere
with the use made and proposed to be made of such property and buildings by the Company.
(ee) The Company possess and is operating in compliance with such valid
and current material certificates, authorizations or permits required by United States federal, state or foreign regulatory agencies or
bodies to conduct its business as currently conducted and as described in the Registration Statement and the Prospectus (collectively,
“Permits”). The Company is not in violation of, or in default under, any of the Permits or has not received
any written notice of proceedings relating to the revocation or modification of, or non-compliance with, any such certificate, authorization
or permit, which, individually or in the aggregate, if the subject of an unfavorable decision, ruling or finding, could reasonably be
expected to result in a Material Adverse Effect.
(ff) The Company makes and keeps accurate books and records and maintains
a system of internal accounting controls designed, and which the Company believes is sufficient to provide reasonable assurance that:
(i) transactions are executed in accordance with management’s general or specific authorization; (ii) transactions are recorded
as necessary to permit preparation of financial statements in conformity with GAAP and to maintain accountability for assets; (iii) access
to assets is permitted only in accordance with management’s general or specific authorization; (iv) the recorded accountability
for assets is compared with existing assets at reasonable intervals and appropriate action is taken with respect to any differences; and
(v) the interactive data in eXtensible Business Reporting Language included or incorporated by reference in the Registration Statement
and the Prospectus fairly presents the information called for in all material respects and is prepared in accordance with the Commission’s
rules and guidelines applicable thereto.
(gg) Except as set forth in the Registration Statement and the Prospectus,
the Company has established and maintains disclosure controls and procedures (as defined in Rules 13a-15 and 15d-15 under the Exchange
Act), which (i) are designed to ensure that information relating to the Company, is made known to the Company’s principal executive
officer and its principal financial officer by others within those entities; (ii) have been evaluated by management of the Company for
effectiveness as of the end of the Company’s most recent fiscal quarter; and (iii) are effective in all material respects to perform
the functions for which they were established. Except as set forth in the Registration Statement and the Prospectus, since the end of
the Company’s most recent audited fiscal year, there has been no material weakness in the Company’s internal control over
financial reporting (whether or not remediated) and no change in the Company’s internal control over financial reporting, including
any corrective actions with regard to significant deficiencies or material weaknesses. The Company is not aware of any change in its internal
control over financial reporting that has occurred during its most recent fiscal quarter that has materially affected, or is reasonably
likely to materially affect, the Company’s internal control over financial reporting.
(hh) Neither the Company, nor to the knowledge of the Company, any
of its respective directors, officers or controlling persons has taken, directly or indirectly, without giving effect to any actions taken
by the Agent, (i) any action designed to or that might constitute or reasonably be expected to cause or result in, under the Exchange
Act or otherwise, stabilization or manipulation of the price of any security of the Company to facilitate the sale or resale of the Placement
Shares or (ii) any action designed to or that might constitute or reasonably be expected to cause or result in a violation of Regulation
M under the Exchange Act.
(ii) Except as could not reasonably be expected, individually or in
the aggregate, to have a Material Adverse Effect: (i) the Company is not in violation of any United States federal, state or local, or
any foreign, statute, law, rule, regulation, ordinance, code, policy or rule of common law or any judicial or administrative interpretation
thereof, including any judicial or administrative order, consent, decree or judgment, relating to pollution or protection of human health,
the environment (including, without limitation, ambient air, surface water, groundwater, land surface or subsurface strata) or wildlife,
including, without limitation, laws and regulations relating to the emissions, discharges, release or threatened release of chemicals,
pollutants, contaminants, wastes, toxic substances, hazardous substances, petroleum or petroleum products (collectively, “Hazardous
Materials”) or otherwise related to the manufacture, processing, distribution, use, treatment, storage, disposal, transport
or handling of Hazardous Materials (collectively, “Environmental Laws”), which violation includes, but is not
limited to, noncompliance with any permits or other governmental authorizations required for the operation of the business of the Company
under applicable Environmental Laws, or noncompliance with the terms and conditions thereof, nor has the Company received any written
communication, whether from a governmental authority, citizens group, employee or otherwise, that alleges that the Company is in violation
of any Environmental Law; (ii) the Company has all material permits, authorizations and approvals required under any applicable Environmental
Laws and are in compliance with their requirements; (iii) there are no pending or, to the Company’s knowledge, threatened administrative,
regulatory or judicial actions, suits, demands, demand letters, claims, liens, notices of noncompliance or violation, investigation or
proceedings relating to any Environmental Law against the Company, or any investigation with respect to which the Company has received
written notice or any written notice by any person or entity alleging potential liability for investigatory costs, cleanup costs, governmental
responses costs, natural resources damages, property damages, personal injuries, attorneys’ fees or penalties arising out of, based
on or resulting from the presence, or release into the environment, of any Hazardous Materials at any location owned, leased or operated
by the Company; and (iv) to the Company’s knowledge, there are no past or present actions, activities, events, conditions, incidents
or circumstances that might reasonably be expected to result in a violation of any Environmental Law or form the basis of an order for
clean-up or remediation, or an action, suit, investigation or proceeding by any private party or governmental body or agency, against
or affecting the Company relating to Hazardous Materials or any Environmental Laws.
(jj) There are no costs or liabilities associated with Environmental
Laws (including, without limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance
with Environmental Laws or any permit, license or approval, any related constraints on operating activities and any potential liabilities
to third parties) which would, singly or in the aggregate, have a Material Adverse Effect on the Company, taken as a whole.
(kk) The Company is in material compliance with, and there is and has
been no failure on the part of the Company and, to the Company’s knowledge, any of the Company’s directors or officers, in
their capacities as such, to comply with, any provision of the Sarbanes-Oxley Act of 2002 and all rules and regulations promulgated thereunder
or implementing the provisions thereof (the “Sarbanes-Oxley Act”) and the rules and regulations promulgated
in connection therewith, including Section 402 relating to loans.
(ll) Neither the Company, nor, to the knowledge of the Company, any
of its respective directors, officers, agents, employees or affiliates, has taken or will take any action in furtherance of an offer,
payment, promise to pay, or authorization or approval of the unlawful payment or giving of money, property, gifts or anything else of
value, directly or indirectly, to any “government official” (including any officer or employee of a government or government-owned
or controlled entity or of a public international organization, or any person acting in an official capacity for or on behalf of any of
the foregoing, or any political party or party official or candidate for political office) to influence official action or secure an improper
advantage; and the Company, and, to the Company’s knowledge, each of their respective affiliates have conducted their businesses
in compliance with applicable anti-corruption laws.
(mm) Neither the Company nor any director or officer of the Company,
nor to the knowledge of the Company, any employee, agent, affiliate or other person acting on behalf of the Company has, in the course
of its actions for, or on behalf of, the Company (i) used any corporate funds for any unlawful contribution, gift, entertainment or other
unlawful expenses relating to political activity; (ii) made or taken any act in furtherance of an offer, promise, or authorization of
any direct or indirect unlawful payment or benefit to any foreign or domestic government official or employee, including of any government-owned
or controlled entity or public international organization, or any political party, party official, or candidate for political office;
(iii) violated or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended (the “FCPA”),
the UK Bribery Act 2010, or any other applicable anti-bribery or anti-corruption law; or (iv) made, offered, authorized, requested, or
taken an act in furtherance of any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment or benefit. The
Company and, to the knowledge of the Company, the Company’s affiliates have conducted their respective businesses in compliance
with the FCPA and have instituted and maintain policies and procedures designed to ensure, and which are reasonably expected to continue
to ensure, continued compliance therewith.
(nn) The operations of the Company are and have been conducted at all
times in compliance with applicable financial recordkeeping and reporting requirements, including those of the Bank Secrecy Act, as amended
by Title III of the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act
of 2001 (USA PATRIOT Act), and the money laundering statutes and the rules and regulations thereunder and any related or similar rules,
regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the “Money Laundering
Laws”) and no action, suit, investigation or proceeding by or before any court or governmental agency, authority or body
or any arbitrator involving the Company with respect to the Money Laundering Laws is pending or, to the best of the Company’s knowledge,
threatened.
(oo) Neither the Company nor any director or officer thereof, nor,
to the Company’s knowledge, any employee, agent, affiliate or representative of the Company, is currently or is owned or controlled
by an individual or entity that is subject to any sanctions administered or enforced by the United States government (including, without
limitation, the Office of Foreign Assets Control of the United States Department of the Treasury), the United Nations Security Council,
the European Union, His Majesty’s Treasury or other relevant sanctions authority (collectively, “Sanctions”)
or is located, organized or resident in a country or territory that is the subject or target of Sanctions; and the Company will not directly
or indirectly use the proceeds of the sale of the Placement Shares, or lend, contribute or otherwise make available such proceeds to any
joint venture partner or other person or entity, for the purpose of financing or facilitating the activities of or business of any person
or entity, or in any country or territory, that currently or at the time of such financing or facilitation is the subject of any Sanctions
or in any other manner that will result in a violation by any person or entity (including any person participating in the transactions
contemplated by this Agreement) of any Sanctions. For the past five years, the Company has not engaged in and is not now engaged in any
dealings or transactions with any person or entity, or in any country or territory, that at the time of the dealing or transaction is
or was the subject of Sanctions.
(pp) Except as set forth in the Registration Statement and the Prospectus,
the Company owns or possesses the right to use all inventions, patent applications, patents, trademarks, trade names, service names, domain
names, copyrights, trade secrets, know-how and other intellectual property (collectively, “Intellectual Property”)
as are (i) necessary or material for the conduct of their respective businesses as currently conducted or as currently proposed to be
conducted and as described in the Registration Statement and the Prospectus and (ii) necessary or material for the commercialization of
the products described in the Registration Statement and the Prospectus as being under development. There is no pending or, to the Company’s
knowledge, threatened (i) action, suit, proceeding, or claim by others challenging the rights of the Company in or to any such Intellectual
Property that, if decided adversely to the Company would, individually or in the aggregate, have a Material Adverse Effect, and the Company
is unaware of any facts which would form a reasonable basis for any such claim; (ii) action, suit, proceeding, or claim by others that
the Company infringes, misappropriates, or otherwise violates any Intellectual Property of others that, if decided adversely to the Company
would, individually or in the aggregate, have a Material Adverse Effect, and the Company is unaware of any facts which would form a reasonable
basis for any such claim; or (iii) action, suit, proceeding, or claim by others challenging the validity, scope, or enforceability of
any such Intellectual Property owned or licensed by the Company and the Company is unaware of any facts which would form a reasonable
basis for any such claim. To the best of the Company’s knowledge, the operation of the business of the Company as now conducted,
and as described in the Prospectus, and in connection with the development and commercialization of the products described in the Prospectus
does not infringe, misappropriate, conflict with or otherwise violate any claim of any patent of any other person or entity. There is
no prior art of which the Company is aware that may render any patent owned or licensed by the Company invalid or any patent application
owned or licensed by the Company and material to the Company’s operations, unpatentable which has not been disclosed to the applicable
government patent office. The Company’s granted or issued patents (owned or licensed in), registered trademarks and registered copyrights
have been duly maintained and are in full force and effect, and none of the patents, trademarks and copyrights have been adjudged invalid
or unenforceable in whole or in part. The Company knows of no infringement, misappropriation or violation by others of any Intellectual
Property owned or licensed by the Company which would reasonably be expected to have a Material Adverse Effect. The Company is not a party
to or bound by any options, licenses or agreements with respect to the Intellectual Property of any other person or entity that are required
to be set forth in the Prospectus and that are not described therein in all material respects. The Company has taken all reasonable steps
necessary to secure its interests in the Intellectual Property of the Company from their employees and contractors and to protect the
confidentiality of all of their confidential information and trade secrets. None of the technology or intellectual property used by the
Company in its business has been obtained or is being used by the Company in violation of any contractual obligation binding on the Company,
or, to the Company’s knowledge, any of its officers, directors or employees or otherwise in violation of the rights of any persons.
No third party has been granted by the Company rights to the Intellectual Property of the Company, including any rights that, if exercised,
could enable such party to develop products competitive to those of the Company as described in the Registration Statement and the Prospectus.
All Intellectual Property owned or exclusively licensed by the Company is free and clear of all liens, encumbrances, defects or other
restrictions (other than non-exclusive licenses granted in the ordinary course of business), except those that could not reasonably be
expected, individually or in the aggregate, to have a Material Adverse Effect. The Company is not subject to any judgment, order, writ,
injunction or decree of any court or any federal, state, local, foreign or other governmental department, commission, board, bureau, agency
or instrumentality, domestic or foreign, or any arbitrator, nor has it entered into or is it a party to any agreement made in settlement
of any pending or threatened litigation, which materially restricts or impairs their use of any Intellectual Property.
(qq) All patent and patent applications owned by or licensed to the
Company have been duly and properly filed, prosecuted and maintained in all material respects; to the knowledge of the Company, the parties
prosecuting the patent applications owned or co-owned by, or licensed to the Company and patent applications from which patents owned
or co-owned by, or licensed to the Company have issued have complied with their duty of candor and disclosure to the U.S. Patent and Trademark
Office in connection with such applications; and the Company is not aware of any facts required to be disclosed to the USPTO that were
not disclosed to the USPTO and which would preclude the grant of a patent in connection with any such application or would reasonably
be expected to form the basis of a finding of invalidity with respect to any patents that have been issued with respect to such applications.
(rr) There is no legal or governmental proceeding to which the Company
is a party or of which any property or assets of the Company is the subject, including any proceeding before the U.S. Food and Drug Administration
(“FDA”), the European Medicines Agency (“EMA”) or any foreign, local, national or
other governmental agency with jurisdiction over the types of products being developed by the Company that is required to be described
in the Registration Statement or the Prospectus and is not described therein, or which, singularly or in the aggregate, if determined
adversely to the Company, could reasonably be expected to have a Material Adverse Effect; and no such proceedings are threatened or contemplated
by governmental or regulatory authorities or threatened by others. The Company (i) has not received notice of any claim, action, suit,
proceeding, hearing, enforcement, investigation, arbitration or other action from any governmental authority or third party alleging that
any product operation or activity is in violation of any Applicable Laws (as defined below) or Governmental Permits (as defined below)
and have no knowledge that any such governmental authority or third party is considering any such claim, litigation, arbitration, action,
suit, investigation or proceeding and (ii) has not received notice that any governmental authority has taken, is taking or intends to
take action to limit, suspend, modify or revoke any Governmental Permits and the Company has no knowledge that any such governmental authority
is considering such action.
(ss) The research, non-clinical pre-clinical studies and clinical studies
and tests conducted or being conducted by or on behalf of the Company or in which any of their respective product candidates have participated
and, to the Company’s knowledge, the preclinical studies and clinical trials directed or sponsored by the Company’s collaborators
(collectively, the “Studies”) that are described in, or the results of which are referred to in, the Registration
Statement and the Prospectus were and, if still pending, are being conducted with reasonable care and in all material respects in accordance
with the protocols, procedures and controls pursuant to all Applicable Laws and Governmental Permits and with standard medical and scientific
research procedures; each description of the results of such Studies is accurate and complete in all material respects and fairly presents
the data derived from such Studies, and the Company has no knowledge of any other research, non-clinical studies or tests the results
of which are inconsistent with, or otherwise call into question, the results described or referred to in the Registration Statement and
the Prospectus; the Company has made all such filings and obtained all such approvals as may be required by the EMA, the FDA or any committee
thereof or from any other United States or foreign government agency with jurisdiction over the types of products being developed by the
Company; the Company has received any notice of, or correspondence from, any governmental authority requiring the termination, suspension
or modification of any Study; and the Company has operated and currently is in compliance in all material respects with all applicable
rules, regulations and policies of all governmental authorities. There have been no material serious adverse events resulting from any
Study. To the Company’s knowledge, the manufacturing facilities and operations of its suppliers are operated in compliance in all
material respects with all Applicable Laws and Governmental Permits.
(tt) None of the Company, any of its officers, directors or managing
employees (as defined in 42 U.S.C. § 1320a-5(b)) or, to the knowledge of the Company, agents, is or has been excluded, suspended
or debarred from participation in any state or federal health care program, or made subject to any pending or, to the Company’s
knowledge, threatened or contemplated action which could reasonably be expected to result in such exclusion, suspension or debarment.
The Company is not a party to or has any ongoing reporting obligations pursuant to any corporate integrity agreement, deferred or non-prosecution
agreement, monitoring agreement, consent decree, settlement order, plan of correction or similar agreement imposed by any governmental
authority.
(uu) Other than with respect to this agreement and as disclosed in
the Company’s filings with the Commission, the Company is not a party to any agreement with an agent or underwriter for any other
“at the market” or continuous equity transaction.
(vv) The Company is not required to register as a “broker”
or “dealer” in accordance with the provisions of the Exchange Act and does not, directly or indirectly through one or more
intermediaries, control or have any other association with (within the meaning of Article I of the By-laws of FINRA) any member firm of
FINRA. No relationship, direct or indirect, exists between or among the Company, on the one hand, and the directors, officers or shareholders
of the Company, on the other hand, which is required by the rules of FINRA to be described in the Registration Statement and the Prospectus,
which is not so described. All of the information (including, but not limited to, information regarding affiliations, security ownership
and trading activity) provided to the Agent or its counsel by the Company, its officers and directors and the holders of any securities
(debt or equity) or warrants, options or rights to acquire any securities of the Company in connection with the filing to be made and
other supplemental information to be provided to FINRA pursuant to FINRA Rule 5110 in connection with the transactions contemplated by
this Agreement is true, complete and correct.
(ww) Neither the issuance, sale and delivery of the Placement Shares
nor the application of the proceeds thereof by the Company as described in the Registration Statement and the Prospectus will violate
Regulation T, U or X of the Board of Governors of the Federal Reserve System or any other regulation of such Board of Governors.
(xx) Each of the independent directors (or independent director nominees,
once appointed, if applicable) named in the Registration Statement and Prospectus satisfies the independence standards established by
Nasdaq and, with respect to members of the Company’s audit committee, the enhanced independence standards contained in Rule 10A-3(b)(1)
promulgated by the Commission under the Exchange Act.
(yy) Neither the Company nor, to the Company’s knowledge, any
of its affiliates (within the meaning of Rule 144 under the Securities Act) has, prior to the date hereof, made any offer or sale of any
securities which could be “integrated” (within the meaning of the Securities Act) with the offer and sale of the Placement
Shares hereunder.
(zz) The Company has not (i) failed to pay any dividend or sinking
fund installment on preferred stock or (ii) defaulted on any installment or payment due on indebtedness for borrowed money or on any rental
on one or more long-term leases, which defaults, individually or in the aggregate, could reasonably be expected to result in a Material
Adverse Effect.
(aaa) Each financial or operational projection or other “forward-looking
statement” (as defined by Section 27A of the Securities Act or Section 21E of the Exchange Act) contained in the Registration Statement
or the Prospectus (i) was so included by the Company in good faith and with reasonable basis after due consideration by the Company of
the underlying assumptions, estimates and other applicable facts and circumstances and (ii) as required, is accompanied by meaningful
cautionary statements identifying those factors that could cause actual results to differ materially from those in such forward-looking
statement. No such statement was made with the knowledge of a director or senior manager of the Company that was false or misleading.
(bbb) There are no relationships, direct or indirect, or related party
transactions involving the Company or any other person (including any director, officer, stockholder, customer or supplier of the Company)
required to be described in the Registration Statement or the Prospectus that have not been described as required. There are no material
outstanding loans, advances (except normal advances for business expenses in the ordinary course of business) or guarantees of indebtedness
by the Company to or for the benefit of any of the officers or directors of the Company, or any of the family members of any of such persons.
(ccc) The Company is not in or subject to a bankruptcy or insolvency
proceeding in any jurisdiction.
(ddd) Except as would not have a Material Adverse Effect, the Company
has not breached and is not currently in breach of any provision of any license, contract or other agreement governing the use by the
Company of Intellectual Property owned by third parties (collectively, the “Licenses”) and no third party has
alleged any such breach and the Company is unaware of any facts that would form a reasonable basis for such a claim. To the Company’s
knowledge, no other party to the Licenses has breached or is currently in breach of any provision of the Licenses. Each of the Licenses
is in full force and effect and constitutes a valid and binding agreement between the parties thereto, enforceable in accordance with
its terms, and there has not occurred any breach or default under any such Licenses or any event that, with the giving of notice or lapse
of time, would constitute a breach or default thereunder. Except as would not have a Material Adverse Effect, the Company has not been
and is not currently involved in any disputes regarding the Licenses. To the Company’s knowledge, all patents licensed to the Company
pursuant to the Licenses are valid, enforceable and being duly maintained. To the Company’s knowledge, all patent applications licensed
to the Company pursuant to the Licenses are being duly prosecuted.
(eee) The Company does not have any securities rated by any “nationally
recognized statistical rating organization,” as such term is defined in Section 3(a)(62) of the Exchange Act.
(fff) The Company and any “employee benefit plan” (as defined
under the Employee Retirement Income Security Act of 1974, as amended, and the regulations and published interpretations thereunder (collectively,
“ERISA”)) established or maintained by the Company, or its “ERISA Affiliates” (as defined below)
are in compliance in all material respects with ERISA. “ERISA Affiliates” means, with respect to the Company, any member of
any group of organizations described in Sections 414(b), (c), (m) or (o) of the Internal Revenue Code of 1986, as amended, and the regulations
and published interpretations thereunder (the “Code”) of which the Company is a member. No “reportable
event” (as defined under ERISA) has occurred or is reasonably expected to occur with respect to any “employee benefit plan”
established or maintained by the Company, or any of its ERISA Affiliates. No “employee benefit plan” established or maintained
by the Company or any of its ERISA Affiliates, if such “employee benefit plan” were terminated, would have any “amount
of unfunded benefit liabilities” (as defined under ERISA). Neither the Company nor any of its ERISA Affiliates has incurred or reasonably
expects to incur any liability under (i) Title IV of ERISA with respect to termination of, or withdrawal from, any “employee benefit
plan” or (ii) Sections 412, 4971, 4975 or 4980B of the Code. Each “employee benefit plan” established or maintained
by the Company or any of its ERISA Affiliates that is intended to be qualified under Section 401(a) of the Code is so qualified and nothing
has occurred, whether by action or failure to act, which would cause the loss of such qualification.
(ggg) The Company (i) is and has at all times been in full compliance
with all laws, statutes, rules, regulations or guidance applicable to the Company and the ownership, testing, development, manufacture,
packaging, processing, use, distribution, marketing, advertising, labeling, promotion, sale, offer for sale, storage, import, export or
disposal of any pharmaceuticals or biohazardous substances, materials or any other products developed, manufactured or distributed by
the Company (including, without limitation, from the FDA, EMA and any local or other governmental or regulatory authority performing functions
similar to those performed by the FDA or EMA) (collectively, “Applicable Laws”), except as could not, individually
or in the aggregate, reasonably be expected to result in a Material Adverse Effect, (ii) has not received any notice of adverse finding,
warning letter, untitled letter or other correspondence or notice from the FDA or any other federal, state or foreign governmental authority
having authority over the Company, or its activities alleging or asserting noncompliance with any Applicable Laws or any licenses, certificates,
approvals, clearances, authorizations, permits and supplements or amendments thereto required by any such Applicable Laws (collectively,
the “Governmental Permits”), (iii) has made all filings with, the appropriate local, or other governmental or
regulatory agencies or bodies that are necessary for the ownership or lease of their respective properties or the conduct of their respective
businesses as described in the Registration Statement and the Prospectus, except where any failures to possess or make the same would
not, singularly or in the aggregate, have a Material Adverse Effect, (iv) possesses all material Governmental Permits necessary to conduct
its respective businesses as described in the Registration Statement and the Prospectus, and such Governmental Permits are valid and in
full force and effect and are not in violation of any term of any such Governmental Permits, (v) has filed, obtained, maintained or submitted
all material reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as required
by any Applicable Laws or Governmental Permits and that all such reports, documents, forms, notices, applications, records, claims, submissions
and supplements or amendments were complete and correct in all material respects on the date filed (or were corrected or supplemented
by a subsequent submission), and (vi) is not a party to any corporate integrity agreements, monitoring agreements, consent decrees, settlement
orders or similar agreements with or imposed by any governmental authority. All Governmental Permits are valid and in full force and effect,
except where the validity or failure to be in full force and effect would not, singularly or in the aggregate, have a Material Adverse
Effect. The Company has not received notification of any revocation, modification, suspension, termination or invalidation (or proceedings
related thereto) of any such Governmental Permit and the Company has no reason to believe that any such Governmental Permit will not be
renewed. Neither the Company, nor, to the Company’s knowledge, any of its respective directors, officers, employees or agents has
been convicted of any crime under any Applicable Laws or has been the subject of an FDA debarment proceeding. The Company has not been
nor is now subject to the FDA’s Application Integrity Policy. To the Company’s knowledge, neither the Company, nor any of
its directors, officers, employees or agents has made, or caused the making of, any false statements on, or material omissions from, any
other records or documentation prepared or maintained to comply with the requirements of the FDA or any other governmental authority.
(hhh) None of the Company’s product candidates have received
marketing approval from the FDA or any other federal, state, local or foreign governmental or regulatory authority.
(iii) The Company acknowledges and agrees that the Agent has informed
the Company that the Agent may, to the extent permitted under the Securities Act and the Exchange Act, purchase and sell shares of Common
Stock for its own account while this Agreement is in effect; provided, that (i) no such purchase or sales shall take place while
a Placement Notice is in effect (except to the extent the Agent may engage in sales of Placement Shares purchased or deemed purchased
from the Company as a “riskless principal” or in a similar capacity) and (ii) the Company shall not be deemed to have authorized
or consented to any such purchases or sales by the Agent, except as may be otherwise agreed by the Company and the Agent.
(jjj) The Company’s information technology assets and equipment,
computers, systems, networks, hardware, software, websites, applications, and databases (collectively, “IT Systems”)
are adequate for, and operate and perform, in each case, in all material respects, as required in connection with the operation of the
business of the Company as currently conducted, free and clear of all material bugs, errors, defects, Trojan horses, time bombs, malware
and other corruptants. The Company has implemented and maintained commercially reasonable physical, technical and administrative controls,
policies, procedures, and safeguards to maintain and protect their material confidential information and the integrity, continuous operation,
redundancy and security of all IT Systems and data, including “Personal Data,” used in connection with their businesses. “Personal
Data” means (i) a natural person’s name, street address, telephone number, e-mail address, photograph, social security
number or tax identification number, driver’s license number, passport number, credit card number, bank information, or customer
or account number; (ii) any information which would qualify as “personally identifying information” under the Federal Trade
Commission Act, as amended; (iii) “personal data” as defined by GDPR (as defined below); (iv) any information which would
qualify as “protected health information” under the Health Insurance Portability and Accountability Act of 1996, as amended
by the Health Information Technology for Economic and Clinical Health Act (collectively, “HIPAA”); and (v) any
other piece of information that allows the identification of such natural person, or his or her family, or permits the collection or analysis
of any data related to an identified person’s health or sexual orientation. There have been no breaches, violations, outages or
unauthorized uses of or accesses to same, except for those that have been remedied without material cost or liability or the duty to notify
any other person, nor any incidents under internal review or investigations relating to the same. The Company is presently in material
compliance with all applicable laws or statutes and all judgments, orders, rules and regulations of any court or arbitrator or governmental
or regulatory authority, internal policies and contractual obligations relating to the privacy and security of IT Systems and Personal
Data and to the protection of such IT Systems and Personal Data from unauthorized use, access, misappropriation or modification.
(kkk) The Company is, and at all prior times was, in material compliance
with all applicable state and federal data privacy and security laws and regulations, including without limitation HIPAA, and the Company
has taken commercially reasonable actions to prepare to comply with, and since May 25, 2018, has been and currently is in compliance with,
the European Union General Data Protection Regulation (“GDPR”) (EU 2016/679) (collectively, the “Privacy Laws”).
To ensure compliance with the Privacy Laws, the Company has in place, complies with, and takes appropriate steps reasonably designed to
ensure compliance in all material respects with its policies and procedures relating to data privacy and security and the collection,
storage, use, disclosure, handling, and analysis of Personal Data (the “Policies”). The Company has at all times
made all disclosures to users or customers required by applicable laws and regulatory rules or requirements, and none of such disclosures
made or contained in any Policy have, to the knowledge of the Company, been inaccurate or in violation of any applicable laws and regulatory
rules or requirements in any material respect. The Company further certifies that: (i) it has not received notice of any actual or potential
liability under or relating to, or actual or potential violation of, any of the Privacy Laws, and has no knowledge of any event or condition
that would reasonably be expected to result in any such notice; (ii) it is not currently conducting or paying for, in whole or in part,
any investigation, remediation, or other corrective action pursuant to any Privacy Law; or (iii) it is not a party to any order, decree,
or agreement that imposes any obligation or liability under any Privacy Law.
Any certificate signed by any officer of the Company and delivered
to the Agent or its counsel in connection with the offering of the Placement Shares shall be deemed a representation and warranty by the
Company, as to matters covered thereby, to the Agent.
7. Covenants of the Company. The Company covenants and agrees
with the Agent that:
(a) Registration Statement Amendments. After the date of this
Agreement and during any period in which the Prospectus relating to any Placement Shares is required to be delivered by the Agent under
the Securities Act (including in circumstances where such requirement may be satisfied pursuant to Rule 172 under the Securities Act or
a similar rule); (i) the Company will notify the Agent promptly of the time when any subsequent amendment to the Registration Statement,
other than Incorporated Documents, has been filed with the Commission and/or has become effective or any subsequent supplement to the
Prospectus, other than Incorporated Documents, has been filed and of any request by the Commission for any amendment or supplement to
the Registration Statement or Prospectus or for additional information; (ii) the Company will prepare and file with the Commission, promptly
upon the Agent’s request, any amendments or supplements to the Registration Statement or Prospectus that, in the Agent’s reasonable
opinion, may be necessary or advisable in connection with the distribution of the Placement Shares by the Agent (provided, however, that
the failure of the Agent to make such request shall not relieve the Company of any obligation or liability hereunder, or affect the Agent’s
right to rely on the representations and warranties made by the Company in this Agreement and provided, further, that the only remedy
the Agent shall have with respect to the failure by the Company to make such filing (but without limiting the Agent’s rights under
Section 9 hereof) will be to cease making sales under this Agreement until such amendment or supplement is filed); (iii) the Company will
not file any amendment or supplement to the Registration Statement or Prospectus, other than Incorporated Documents, relating to the Placement
Shares or a security convertible into or exchangeable or exercisable for the Placement Shares unless a copy thereof has been submitted
to the Agent within a reasonable period of time before the filing and the Agent has not reasonably objected thereto (provided, however,
that (A) the failure of the Agent to make such objection shall not relieve the Company of any obligation or liability hereunder, or affect
the Agent’s right to rely on the representations and warranties made by the Company in this Agreement and (B) the Company has no
obligation to provide the Agent any advance copy of such filing or to provide the Agent an opportunity to object to such filing if the
filing does not name the Agent or does not relate to the transaction herein provided; and provided, further, that the only remedy the
Agent shall have with respect to the Company’s making such filing notwithstanding the Agent’s objection (but without limiting
the Agent’s rights under Section 9 hereof) will be to cease making sales under this Agreement) and the Company will furnish to the
Agent at the time of filing thereof a copy of any Incorporated Document, except for those documents available via EDGAR; and (iv) the
Company will cause each amendment or supplement to the Prospectus, other than Incorporated Documents, to be filed with the Commission
as required pursuant to the applicable paragraph of Rule 424(b) of the Securities Act and, in the case of any Incorporated Document, to
be filed with the Commission as required pursuant to the Exchange Act, within the time period prescribed (the determination to file or
not file any amendment or supplement with the Commission under this Section 7(a), based on the Company’s reasonable opinion or objections,
shall be made exclusively by the Company).
(b) Notice of Commission Stop Orders. The Company will advise
the Agent, promptly after it receives notice or obtains knowledge thereof, of the issuance or threatened issuance by the Commission of
any stop order suspending the effectiveness of the Registration Statement, of the suspension of the qualification of the Placement Shares
for offering or sale in any jurisdiction or of the initiation or threatening of any proceeding for any such purpose; and it will promptly
use its commercially reasonable efforts to prevent the issuance of any stop order or to obtain its withdrawal if such a stop order should
be issued. The Company will advise the Agent promptly after it receives any request by the Commission for any amendments to the Registration
Statement related to the Placement Shares or any amendment or supplements to the Prospectus or for additional information related to the
offering of the Placement Shares or for additional information related to the Registration Statement or the Prospectus, in each case,
with respect to the Placement Shares.
(c) Delivery of Prospectus; Subsequent Changes. During any period
in which the Prospectus relating to the Placement Shares is required to be delivered by the Agent under the Securities Act with respect
to the offer and sale of the Placement Shares (including in circumstances where such requirement may be satisfied pursuant to Rule 172
under the Securities Act or a similar rule), the Company will comply in all material respects with all requirements imposed upon it by
the Securities Act, as from time to time in force, and will file on or before their respective due dates (taking into account any extensions
available under the Exchange Act) all reports and any definitive proxy or information statements required to be filed by the Company with
the Commission pursuant to Sections 13(a), 13(c), 14, 15(d) or any other provision of or under the Exchange Act. If during such period
any event occurs as a result of which the Prospectus as then amended or supplemented would include an untrue statement of a material fact
or omit to state a material fact necessary to make the statements therein, in the light of the circumstances then existing, not misleading,
or if during such period it is necessary to amend or supplement the Registration Statement or Prospectus to comply with the Securities
Act, the Company will promptly notify the Agent to suspend the offering of Placement Shares during such period and the Company will promptly
amend or supplement the Registration Statement or Prospectus (at the expense of the Company) so as to correct such statement or omission
or effect such compliance; provided, however, that the Company may delay the filing of any amendment or supplement, if in the judgment
of the Company, it is in the best interests of the Company; provided, however, that Company will promptly notify the Agent of such decision
to delay. If the Company has omitted any information with respect to the Placement Shares from the Registration Statement pursuant to
Rule 430B under the Securities Act, it will use its reasonable best efforts to comply with the provisions thereof and make all requisite
filings with the Commission pursuant to said Rule 430B and to notify the Agent promptly of all such filings if not available on EDGAR.
(d) Listing of Placement Shares. During any period in which
the Prospectus relating to the Placement Shares is required to be delivered by the Agent under the Securities Act with respect to the
offer and sale of the Placement Shares (including in circumstances where such requirement may be satisfied pursuant to Rule 172 under
the Securities Act or a similar rule), the Company will use its commercially reasonable efforts to cause the Placement Shares to be listed
on Nasdaq. The Company will timely file with Nasdaq all material documents and notices required by Nasdaq of companies that have or will
issue securities that are traded on Nasdaq.
(e) Delivery of Registration Statement and Prospectus. The Company
will furnish to the Agent and its counsel (at the expense of the Company) copies of the Registration Statement, the Prospectus (including
all Incorporated Documents) and all amendments and supplements to the Registration Statement or Prospectus that are filed with the Commission
during any period in which the Prospectus relating to the Placement Shares is required to be delivered under the Securities Act (including
all Incorporated Documents filed with the Commission during such period), in each case as soon as reasonably practicable and in such quantities
as the Agent may from time to time reasonably request and, at the Agent’s request, will also furnish copies of the Prospectus to
each exchange or market on which sales of the Placement Shares may be made; provided, however, that the Company shall not
be required to furnish any document (other than the Prospectus) to the Agent to the extent such document is available on EDGAR.
(f) Earnings Statement. The Company will make generally available
to its security holders and to the Agent as soon as practicable, but in any event not later than 15 months after the end of the Company’s
current fiscal quarter, an earnings statement covering a 12-month period that satisfies the provisions of Section 11(a) of and Rule 158
under the Securities Act. The Company shall be deemed to have satisfied this Section 7(f) through public filings if made by the Company
using the EDGAR system.
(g) Expenses. The Company, whether or not the transactions contemplated
hereunder are consummated or this Agreement is terminated in accordance with the provisions of Section 11 hereunder, will pay all expenses
incident to the performance of its obligations hereunder, including expenses relating to (i) the preparation, printing and filing of the
Registration Statement and each amendment and supplement thereto, of the Prospectus and of each amendment and supplement thereto and of
this Agreement and such other documents as may be required in connection with the offering, purchase, sale, issuance or delivery of the
Placement Shares, (ii) the preparation, issuance, sale and delivery of the Placement Shares and any taxes due or payable in connection
therewith, (iii) the qualification of the Placement Shares under securities laws in accordance with the provisions of Section 7(w) of
this Agreement, including filing fees (provided, however, that any fees or disbursements of counsel for the Agent in connection therewith
shall be paid by the Agent except as set forth in clauses (vii) and (viii) below), (iv) the printing and delivery to the Agent and its
counsel of copies of the Prospectus and any amendments or supplements thereto, and of this Agreement, (v) the fees and expenses incurred
in connection with the listing or qualification of the Placement Shares for trading on Nasdaq, (vi) the filing fees and expenses, if any,
owed to the Commission or FINRA and the fees and expenses of any transfer agent or registrar for the Placement Shares, (vii) the fees
and associated expenses of the Agent’s outside legal counsel for filings with the FINRA Corporate Financing Department in an amount
not to exceed $15,000 (excluding the FINRA filing fees referred to in clause (vi) above and in addition to the fees and disbursements
referred to in clause (viii) below), and (viii) the reasonable fees and disbursements of the Agent’s outside legal counsel (A) in
an amount not to exceed $75,000 arising out of executing this Agreement and the Company’s delivery of the initial certificate pursuant
to Section 7(m) and (B) in an amount not to exceed $25,000 in connection with each Representation Date (as defined below) on which the
Company is required to provide a certificate pursuant to Section 7(m) or the last sentence of Section 3 (in addition to the fees and associated
expenses referred to in clause (vii) above).
(h) Use of Proceeds. The Company will use the Net Proceeds as
described in the Prospectus in the section entitled “Use of Proceeds.”
(i) Notice of Other Sales. Without the prior written consent
of the Agent, the Company will not, directly or indirectly, offer to sell, sell, contract to sell, grant any option to sell or otherwise
dispose of any shares of Common Stock (other than the Placement Shares offered pursuant to this Agreement) or securities convertible into
or exchangeable or exercisable for shares of Common Stock, warrants or any rights to purchase or acquire shares of Common Stock during
the period beginning on the date on which any Placement Notice is delivered to Agent hereunder and ending on the second Trading Day immediately
following the final Settlement Date with respect to Placement Shares sold pursuant to such Placement Notice (or, if the Placement Notice
has been terminated or suspended prior to the sale of all Placement Shares covered by a Placement Notice, the date of such suspension
or termination); and will not directly or indirectly in any other “at the market offering” or continuous equity transaction
offer to sell, sell, contract to sell, grant any option to sell or otherwise dispose of any shares of Common Stock (other than the Placement
Shares offered pursuant to this Agreement) or securities convertible into or exchangeable or exercisable for shares of Common Stock, warrants
or any rights to purchase or acquire, shares of Common Stock prior to the termination of this Agreement; provided, however,
that such restrictions will not be required in connection with the Company’s issuance or sale of (i) shares of Common Stock, options
to purchase shares of Common Stock, other securities under the Company’s existing equity incentive plans, or shares of Common Stock
issuable upon the exercise of options or vesting of other securities, pursuant to any employee or director stock option or benefits plan,
stock ownership plan or dividend reinvestment plan (but not shares of Common Stock subject to a waiver to exceed plan limits in its dividend
reinvestment plan) of the Company whether now in effect or hereafter implemented, (ii) shares of Common Stock issuable upon conversion
of securities or the exercise of warrants, options or other rights in effect or outstanding, and disclosed in filings by the Company available
on EDGAR or otherwise in writing to the Agent, (iii) shares of Common Stock or securities convertible into or exchangeable for shares
of Common Stock as consideration for mergers, acquisitions, other business combinations or strategic alliances occurring after the date
of this Agreement which are not issued for capital raising purposes and (iv) issue Common Stock to employees, directors, officers, consultants
and advisors as compensation for employment or services in the ordinary course of business.
(j) Change of Circumstances. The Company will, at any time during
the pendency of a Placement Notice, advise the Agent promptly after it shall have received notice or obtained knowledge of any information
or fact that would alter or affect in any material respect any opinion, certificate, letter or other document provided or required to
be provided to the Agent pursuant to this Agreement.
(k) Due Diligence Cooperation. During the term of this Agreement,
the Company will cooperate with any reasonable due diligence review conducted by the Agent, its affiliates agents and counsel from time
to time in connection with the transactions contemplated hereby, including providing information and making available documents and senior
corporate officers, during regular business hours and at the Company’s principal offices, as the Agent may reasonably request.
(l) Required Filings Relating to Placement of Placement Shares.
The Company agrees that on or prior to such dates as the Securities Act shall require, the Company will (i) file a prospectus supplement
with the Commission under the applicable paragraph of Rule 424(b) under the Securities Act, which prospectus supplement will set forth,
within the relevant period, the number or amount of Placement Shares sold through the Agent, the Net Proceeds to the Company and the compensation
payable by the Company to the Agent with respect to such Placement Shares, and (ii) deliver such number of copies of each such prospectus
supplement to each exchange or market on which such sales were effected as may be required by the rules or regulations of such exchange
or market; provided, that, unless a prospectus supplement containing such information is required to be filed under the Securities
Act, the requirement of this Section 7(l) may be satisfied by Company’s inclusion in the Company’s Form 10-K or Form 10-Q,
as applicable, of the number or amount of Placement Shares sold through the Agent, the Net Proceeds to the Company and the compensation
payable by the Company to the Agent with respect to such Placement Shares during the relevant period.
(m) Representation Dates; Certificate. On or prior to the date
on which the Company first delivers a Placement Notice pursuant to this agreement (the “First Placement Notice Date”)
and each time the Company:
(i) amends or supplements (other than a prospectus supplement relating
solely to an offering of securities other than the Placement Shares) the Registration Statement or the Prospectus relating to the Placement
Shares (other than a prospectus supplement filed in accordance with Section 7(l) of this Agreement) by means of a post-effective amendment,
sticker or supplement but not by means of incorporation of document(s) by reference into the Registration Statement or the Prospectus
relating to the Placement Shares;
(ii) files an annual report on Form 10-K under the Exchange Act (including
any Form 10-K/A containing amended financial information or a material amendment to the previously filed Form 10-K);
(iii) files a quarterly report on Form 10-Q under the Exchange Act;
or
(iv) files a current report on Form 8-K containing amended financial
information (other than an earnings release that is “furnished” pursuant to Item 2.02 or Item 7.01 of Form 8-K or to provide
disclosure pursuant to Item 8.01 of Form 8-K relating to the reclassification of certain properties as discontinued operations in accordance
with Statement of Financial Accounting Standards No. 144) under the Exchange Act (each date of filing of one or more of the documents
referred to in clauses (i) through (iv) shall be a “Representation Date”), the Company shall furnish the Agent
(but in the case of clause (iv) above, only if a Placement Notice is pending or in effect, with a certificate, in the form attached hereto
as Exhibit 7(m) (modified, as necessary, to relate to the Registration Statement and the Prospectus as then amended or supplemented),
within five Trading Days of any Representation Date. The requirement to provide a certificate under this Section 7(m) shall be waived
for any Representation Date occurring at a time at which no Placement Notice is pending or in effect, which waiver shall continue until
the earlier to occur of (1) the date the Company delivers a Placement Notice hereunder (which for such calendar quarter shall be considered
a Representation Date) and (2) the next occurring Representation Date. Notwithstanding the foregoing, if the Company subsequently decides
to sell Placement Shares following a Representation Date on which the Company relied on the waiver referred to in the previous sentence
and did not provide the Agent with a certificate under this Section 7(m), then before the Company delivers a Placement Notice or the Agent
sells any Placement Shares pursuant thereto, the Company shall provide the Agent with a certificate, in the form attached hereto as Exhibit
7(m), dated the date of such Placement Notice. Within two Trading Days of each Representation Date, the Company shall have furnished
to the Agent such further information, certificates and documents as the Agent may reasonably request.
(n) Legal Opinions. On or prior to the First Placement Notice
Date and on any date which the Company is obligated to deliver a certificate pursuant to Section 7(m) for which no waiver is applicable,
the Company shall cause to be furnished to the Agent the written opinion and negative assurance letter of Sheppard, Mullin, Richter &
Hampton LLP, counsel to the Company, or such other counsel reasonably satisfactory to the Agent (“Company Counsel”),
in form and substance satisfactory to the Agent and its counsel, dated the date that the opinion and negative assurance letter are required
to be delivered, modified, as necessary, to relate to the Registration Statement and the Prospectus as then amended or supplemented; provided,
however, that in lieu of such opinion and negative assurance letter for subsequent Representation Dates, Company Counsel may furnish
the Agent with a letter to the effect that the Agent may rely on a prior opinion or negative assurance letter delivered by such counsel
under this Section 7(n) to the same extent as if it were dated the date of such letter (except that statements in such prior opinion or
negative assurance letter shall be deemed to relate to the Registration Statement and the Prospectus as amended or supplemented at such
Representation Date).
(o) Intellectual Property Opinions. On or prior to the First
Placement Notice Date and on any date which the Company is obligated to deliver a certificate pursuant to Section 7(m) for which no waiver
is applicable, the Company shall cause to be furnished to the Agent the written opinions of Goodwin Procter LLP and Squire Patton Boggs
(US) LLP, counsels for the Company with respect to intellectual property matters, or such other intellectual property counsel satisfactory
to the Agent (collectively, the “Intellectual Property Counsels”), in forms and substance satisfactory to the
Agent and its counsel, dated the date that the opinion letters are required to be delivered, modified, as necessary, to relate to the
Registration Statement and the Prospectus as then amended or supplemented; provided, however, that in lieu of such written
opinion for subsequent Representation Dates, the Intellectual Property Counsels may furnish the Agent with letters to the effect that
the Agent may rely on the prior opinion letter delivered by each such counsel under this Section 7(o) to the same extent as if it were
dated the date of each such opinion letter (except that statements in each such prior opinion letter shall be deemed to relate to the
Registration Statement and the Prospectus as amended or supplemented at such Representation Date).
(p) Comfort Letter. On or prior to the First Placement Notice
Date and on any date which the Company is obligated to deliver a certificate pursuant to Section 7(m) for which no waiver is applicable,
the Company shall cause its independent registered public accounting firm (and any other independent accountants whose report is included
in the Registration Statement or the Prospectus) to furnish the Agent letters (the “Comfort Letters”), dated
the date the Comfort Letter is delivered, which shall meet the requirements set forth in this Section 7(p); provided, that if requested
by the Agent, the Company shall cause a Comfort Letter to be furnished to the Agent within 10 Trading Days of the occurrence of any material
transaction or event that necessitates the filing of additional, pro forma, amended or revised financial statements (including any restatement
of previously issued financial statements). Each Comfort Letter shall be in form and substance satisfactory to the Agent and each Comfort
Letter from the Company’s independent registered public accounting firm shall (i) confirm that they are an independent registered
public accounting firm within the meaning of the Securities Act and the PCAOB, (ii) state, as of such date, the conclusions and findings
of such firm with respect to the financial information and other matters ordinarily covered by accountants’ “comfort letters”
to underwriters in connection with registered public offerings (the first such letter, the “Initial Comfort Letter”)
and (iii) update the Initial Comfort Letter with any information that would have been included in the Initial Comfort Letter had it been
given on such date and modified as necessary to relate to the Registration Statement and the Prospectus, as amended and supplemented to
the date of such letter.
(q) Market Activities. The Company will not, directly or indirectly,
and will cause its officers, and directors not to (i) take any action designed to cause or result in, or that constitutes or might reasonably
be expected to constitute, the stabilization or manipulation of the price of any security of the Company to facilitate the sale or resale
of shares of Common Stock or (ii) sell, bid for, or purchase shares of Common Stock in violation of Regulation M, or pay anyone any compensation
for soliciting purchases of the Placement Shares other than the Agent; provided, however, that the Company may bid for and
purchase shares of Common Stock in accordance with Rule 10b-18 under the Exchange Act.
(r) Insurance. The Company shall maintain, or cause to be maintained,
insurance in such amounts and covering such risks as is reasonable and customary for the business for which it is engaged.
(s) Compliance with Laws. The Company shall maintain, or cause
to be maintained, all material environmental certificates, authorizations or permits required by federal, state and local law in order
to conduct their businesses as described in the Prospectus (collectively, “Permits”), and the Company shall conduct
its businesses, or cause its businesses to be conducted, in substantial compliance with such Permits and with applicable Environmental
Laws, except where the failure to maintain or be in compliance with such Permits could not reasonably be expected to result in a Material
Adverse Effect.
(t) Investment Company Act. The Company will conduct its affairs
in such a manner so as to reasonably ensure that it will not be or become, at any time prior to the termination of this Agreement, an
“investment company,” as such term is defined in the Investment Company Act.
(u) Securities Act and Exchange Act. The Company will use its
reasonable best efforts to comply with all requirements imposed upon it by the Securities Act and the Exchange Act as from time to time
in force, so far as necessary to permit the sales of, or dealings in, the Placement Shares as contemplated by the provisions hereof and
the Prospectus.
(v) No Offer to Sell. Other than a free writing prospectus (as
defined in Rule 405 under the Securities Act) approved in advance by the Company and the Agent, neither the Agent nor the Company (including
its agents and representatives, other than the Agent in its capacity as agent) will make, use, prepare, authorize, approve or refer to
any written communication (as defined in Rule 405 under the Securities Act), required to be filed with the Commission, that constitutes
an offer to sell or solicitation of an offer to buy Placement Shares hereunder.
(w) Blue Sky and Other Qualifications. The Company will use
its commercially reasonable efforts, in cooperation with the Agent, to qualify the Placement Shares for offering and sale, or to obtain
an exemption for the Placement Shares to be offered and sold, under the applicable securities laws of such states and other jurisdictions
(domestic or foreign) as the Agent may designate and to maintain such qualifications and exemptions in effect for so long as required
for the distribution of the Placement Shares (but in no event for less than one year from the date of this Agreement); provided, however,
that the Company shall not be obligated to file any general consent to service of process or to qualify as a foreign corporation or as
a dealer in securities in any jurisdiction in which it is not so qualified or to subject itself to taxation in respect of doing business
in any jurisdiction in which it is not otherwise so subject. In each jurisdiction in which the Placement Shares have been so qualified
or exempt, the Company will file such statements and reports as may be required by the laws of such jurisdiction to continue such qualification
or exemption, as the case may be, in effect for so long as required for the distribution of the Placement Shares (but in no event for
less than one year from the date of this Agreement).
(x) Sarbanes-Oxley Act. The Company will maintain and keep accurate
books and records reflecting its assets and maintain internal accounting controls in a manner designed to provide reasonable assurance
regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with
GAAP and including those policies and procedures that (i) pertain to the maintenance of records that in reasonable detail accurately and
fairly reflect the transactions and dispositions of the assets of the Company, (ii) provide reasonable assurance that transactions are
recorded as necessary to permit the preparation of the Company’s financial statements in accordance with GAAP, (iii) that receipts
and expenditures of the Company are being made only in accordance with management’s and the Company’s directors’ authorization,
and (iv) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the
Company’s assets that could have a material effect on its financial statements. The Company will use commercially reasonable efforts
to maintain such controls and other procedures, including, without limitation, those required by Sections 302 and 906 of the Sarbanes-Oxley
Act, and the applicable regulations thereunder that are designed to ensure that information required to be disclosed by the Company in
the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified
in the Commission’s rules and forms, including, without limitation, controls and procedures designed to ensure that information
required to be disclosed by the Company in the reports that it files or submits under the Exchange Act is accumulated and communicated
to the Company’s management, including its principal executive officer and principal financial officer, or persons performing similar
functions, as appropriate to allow timely decisions regarding required disclosure and to ensure that material information relating to
the Company is made known to it by others within the Company, particularly during the period in which such periodic reports are being
prepared.
(y) Emerging Growth Company. The Company will promptly notify
the Agent if the Company ceases to be an Emerging Growth Company at any time prior to the completion of the Agent’s distribution
of the Placement Shares pursuant to this Agreement.
(z) Renewal of Registration
Statement. If, immediately prior to the third anniversary of the initial effective date of the Registration Statement (the
“Renewal Date”), any of the Placement Shares remain unsold, this Agreement has not been terminated and a
Placement Notice is pending or in effect, the Company will, prior to the Renewal Date, file a new shelf registration statement or,
if applicable, an automatic shelf registration statement relating to the Common Stock that may be offered and sold pursuant to this
Agreement (which shall include a prospectus reflecting the number or amount of Placement Shares that may be offered and sold
pursuant to this Agreement), in a form satisfactory to the Agent and its counsel, and, if such registration statement is not an
automatic shelf registration statement, will use its best efforts to cause such registration statement to be declared effective
within 180 days after the Renewal Date. The Company will take all other reasonable actions necessary or appropriate to permit the
public offer and sale of the Placement Shares to continue as contemplated in the expired registration statement and this Agreement.
From and after the effective date thereof, references herein to the “Registration Statement” shall include such new
shelf registration statement or such new automatic shelf registration statement, as the case may be.
(aa) General Instruction I.B.6. of Form S-3. If, from and after
the date of this Agreement, the Company is no longer eligible to use Form S-3 (including pursuant to General Instruction I.B.6.) at the
time it files with the Commission an annual report on Form 10-K or any post-effective amendment to the Registration Statement, then it
shall promptly notify the Agent and, within two Business Days after the date of filing of such annual report on Form 10-K or amendment
to the Registration Statement, the Company shall file a new prospectus supplement with the Commission reflecting the number of shares
of Common Stock available to be offered and sold by the Company under this Agreement pursuant to General Instruction I.B.6. of Form S-3;
provided, however, that the Company may delay the filing of any such prospectus supplement for up to 30 days if, in the
reasonable judgment of the Company, it is in the best interest of the Company to do so, provided that no Placement Notice is in effect
or pending during such time. Until such time as the Company shall have corrected such misstatement or omission or effected such compliance,
the Company shall not notify the Agent to resume the offering of Placement Shares.
(bb) Tax Indemnity. The Company will indemnify and hold harmless
the Agent against any documentary, stamp or similar issue tax, including any interest and penalties, on the issue and sale of the Placement
Shares.
(cc) Transfer Agent. The Company has engaged and will maintain,
at its sole expense, a transfer agent and registrar for the Common Stock.
8. Conditions to the Agent’s Obligations. The obligations
of the Agent hereunder with respect to a Placement will be subject to the continuing accuracy and completeness of the representations
and warranties made by the Company herein (other than those representations and warranties made as of a specified later date), to the
due performance by the Company of its obligations hereunder, to the completion by the Agent of a due diligence review satisfactory to
the Agent in its reasonable judgment, and to the continuing satisfaction (or waiver by the Agent in its sole discretion) of the following
additional conditions:
(a) Registration Statement Effective. The Registration Statement
shall be effective and shall be available for all offers and sales of Placement Shares (i) that have been issued pursuant to all prior
Placement Notices and (ii) that will be issued pursuant to any Placement Notice.
(b) Prospectus Supplement. The Company shall have filed with
the Commission the Prospectus Supplement pursuant to Rule 424(b) under the Securities Act not later than the Commission’s close
of business on the second Business Day following the date of this Agreement.
(c) No Material Notices. None of the following events shall
have occurred and be continuing: (i) receipt by the Company of any request for additional information from the Commission or any other
federal or state governmental authority during the period of effectiveness of the Registration Statement, the response to which would
require any post-effective amendments or supplements to the Registration Statement or the Prospectus; (ii) the issuance by the Commission
or any other federal or state governmental authority of any stop order suspending the effectiveness of the Registration Statement or the
initiation of any proceedings for that purpose; (iii) receipt by the Company of any notification with respect to the suspension of the
qualification or exemption from qualification of any of the Placement Shares for sale in any jurisdiction or the initiation or threatening
of any proceeding for such purpose; or (iv) the occurrence of any event that makes any material statement made in the Registration Statement
or the Prospectus or any material Incorporated Document untrue in any material respect or that requires the making of any changes in the
Registration Statement, the Prospectus or Incorporated Documents so that, in the case of the Registration Statement, it will not contain
any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements
therein not misleading and, in the case of the Prospectus, so that it will not contain any untrue statement of a material fact or omit
to state any material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances
under which they were made, not misleading.
(d) No Misstatement or Material Omission. The Agent shall not
have advised the Company that the Registration Statement or Prospectus, or any amendment or supplement thereto, contains any untrue statement
of fact that in the Agent’s opinion is material, or omits to state a fact that in the Agent’s reasonable opinion is material
and is required to be stated therein or is necessary to make the statements therein not misleading.
(e) Material Changes. Except as contemplated in the Prospectus,
or disclosed in the Company’s reports filed with the Commission, there shall not have been any material adverse change, on a consolidated
basis, in the authorized capital stock of the Company or any Material Adverse Effect or any development that could reasonably be expected
to result in a Material Adverse Effect, or any downgrading in or withdrawal of the rating assigned to any of the Company’s securities
(other than asset backed securities), if any, by any rating organization or a public announcement by any rating organization that it has
under surveillance or review its rating of any of the Company’s securities (other than asset backed securities), if any, the effect
of which, in the reasonable judgment of the Agent (without relieving the Company of any obligation or liability it may otherwise have),
is so material as to make it impracticable or inadvisable to proceed with the offering of the Placement Shares on the terms and in the
manner contemplated in the Prospectus.
(f) Company Counsel Legal Opinions. The Agent shall have received
the opinions and negative assurance letters, as applicable, of Company Counsel and the Intellectual Property Counsels required to be delivered
pursuant to Section 7(n) and Section 7(o), as applicable, on or before the date on which such delivery of such opinions and negative assurance
letters are required pursuant to Section 7(n) and Section 7(o), as applicable.
(g) Agent’s Counsel Legal Opinion. The Agent shall have
received from Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel for the Agent, such opinion or opinions, on or before the date
on which the delivery of the Company Counsel legal opinion is required pursuant to Section 7(n), with respect to such matters as the Agent
may reasonably require, and the Company shall have furnished to such counsel such documents as they may request to enable them to pass
upon such matters.
(h) Comfort Letter. The Agent shall have received the Comfort
Letter required to be delivered pursuant to Section 7(p) on or before the date on which such delivery of such Comfort Letter is required
pursuant to Section 7(p).
(i) Representation Certificate. The Agent shall have received
the certificate required to be delivered pursuant to Section 7(m) on or before the date on which delivery of such certificate is required
pursuant to Section 7(m).
(j) Secretary’s Certificate. On or prior to the First
Placement Notice Date, the Agent shall have received a certificate, signed on behalf of the Company by the Secretary of the Company and
attested to by an executive officer of the Company, dated as of such date and in form and substance satisfactory to the Agent and its
counsel, certifying as to (i) the amended and restated certificate of incorporation of the Company, (ii) the amended and restated bylaws
of the Company, (iii) the resolutions of the board of directors of the Company or duly authorized committee thereof authorizing the execution,
delivery and performance of this Agreement and the issuance and sale of the Placement Shares and (iv) the incumbency of the officers of
the Company duly authorized to execute this Agreement and the other documents contemplated by this Agreement (including each of the officers
set forth on Schedule 2).
(k) No Suspension. The Common Stock shall be duly listed, and
admitted and authorized for trading, subject to official notice of issuance, on Nasdaq. Trading in the Common Stock shall not have been
suspended on, and the Common Stock shall not have been delisted from, Nasdaq.
(l) Other Materials. On each date on which the Company is required
to deliver a certificate pursuant to Section 7(m), the Company shall have furnished to the Agent such appropriate further information,
opinions, certificates, letters and other documents as the Agent may have reasonably requested. All such information, opinions, certificates,
letters and other documents shall have been in compliance with the provisions hereof. The Company shall have furnished the Agent with
conformed copies of such opinions, certificates, letters and other documents as the Agent may have reasonably requested.
(m) Securities Act Filings Made. All filings with the Commission
required by Rule 424(b) or Rule 433 under the Securities Act to have been filed prior to the issuance of any Placement Notice hereunder
shall have been made within the applicable time period prescribed for such filing by Rule 424(b) (without reliance on Rule 424(b)(8) of
the Securities Act) or Rule 433, as applicable.
(n) Approval for Listing. Either (i) the Placement Shares shall
have been approved for listing on Nasdaq, subject only to notice of issuance, or (ii) the Company shall have filed an application for
listing of the Placement Shares on Nasdaq at, or prior to, the First Placement Notice Date and Nasdaq shall have reviewed such application
and not provided any objections thereto.
(o) FINRA. FINRA shall have raised no objection to the terms
of the offering contemplated hereby and the amount of compensation allowable or payable to the Agent as described in the Prospectus.
(p) No Termination Event. There shall not have occurred any
event that would permit the Agent to terminate this Agreement pursuant to Section 11(a).
9. Indemnification and Contribution.
(a) Company Indemnification. The Company agrees to indemnify
and hold harmless the Agent, its affiliates and their respective partners, members, directors, officers, employees and agents, and each
person, if any, who (i) controls the Agent within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act or
(ii) is controlled by or is under common control with the Agent, in each case from and against any and all losses, claims, liabilities,
expenses and damages (including any and all investigative, legal and other expenses reasonably incurred in connection with, and any and
all amounts paid in settlement (in accordance with this Section 9), any action, suit, investigation or proceeding between any of the indemnified
parties and any indemnifying parties or between any indemnified party and any third party (including any governmental or self-regulatory
authority, or otherwise, or any claim asserted or threatened), as and when incurred, to which the Agent, or any such other person may
become subject under the Securities Act, the Exchange Act or other federal or state statutory law or regulation, at common law or otherwise,
insofar as such losses, claims, liabilities, expenses or damages arise out of or are based, directly or indirectly, on (x) any untrue
statement or alleged untrue statement of a material fact contained in the Registration Statement or the Prospectus (or any amendment or
supplement to the Registration Statement or the Prospectus) or in any free writing prospectus or in any application or other document
executed by or on behalf of the Company or based on written information furnished by or on behalf of the Company filed in any jurisdiction
in order to qualify the Common Stock under the securities laws thereof or filed with the Commission, (y) the omission or alleged omission
to state in any such document a material fact required to be stated therein or necessary to make the statements therein (solely with respect
to the Prospectus, in light of the circumstances under which they were made) not misleading or (z) any breach by any of the indemnifying
parties of any of their respective representations, warranties or agreements contained in this Agreement; provided, however,
that this indemnity agreement shall not apply to the extent that such loss, claim, liability, expense or damage arises from the sale of
the Placement Shares pursuant to this Agreement and is caused, directly or indirectly, by an untrue statement or omission, or alleged
untrue statement or omission, made in reliance upon and in conformity with the Agent’s Information. This indemnity agreement will
be in addition to any liability that the Company might otherwise have.
(b) Agent Indemnification. The Agent agrees to indemnify and
hold harmless the Company and its directors and each officer of the Company who signed the Registration Statement, and each person, if
any, who (i) controls the Company within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act or (ii) is
controlled by or is under common control with the Company against any and all loss, liability, claim, damage and expense described in
the indemnity contained in Section 9(a), as incurred, but only with respect to untrue statements or omissions, or alleged untrue statements
or omissions, made in the Registration Statement (or any amendments thereto) or the Prospectus (or any amendment or supplement thereto)
in reliance upon and in conformity with the Agent’s Information.
(c) Procedure. Any party that proposes to assert the right to
be indemnified under this Section 9 will, promptly after receipt of notice of commencement of any action against such party in respect
of which a claim is to be made against an indemnifying party or parties under this Section 9, notify each such indemnifying party of the
commencement of such action, enclosing a copy of all papers served, but the omission so to notify such indemnifying party will not relieve
the indemnifying party from (i) any liability that it might have to any indemnified party otherwise than under this Section 9 and (ii)
any liability that it may have to any indemnified party under the foregoing provision of this Section 9 unless, and only to the extent
that, such omission results in the forfeiture of substantive rights or defenses by the indemnifying party. If any such action is brought
against any indemnified party and it notifies the indemnifying party of its commencement, the indemnifying party will be entitled to participate
in and, to the extent that it elects by delivering written notice to the indemnified party promptly after receiving notice of the commencement
of the action from the indemnified party, jointly with any other indemnifying party similarly notified, to assume the defense of the action,
with counsel reasonably satisfactory to the indemnified party, and after notice from the indemnifying party to the indemnified party of
its election to assume the defense, the indemnifying party will not be liable to the indemnified party for any other legal expenses except
as provided below and except for the reasonable costs of investigation subsequently incurred by the indemnified party in connection with
the defense. The indemnified party will have the right to employ its own counsel in any such action, but the fees, expenses and other
charges of such counsel will be at the expense of such indemnified party unless (1) the employment of counsel by the indemnified party
has been authorized in writing by the indemnifying party, (2) the indemnified party has concluded (based on advice of counsel) that there
may be legal defenses available to it or other indemnified parties that are different from or in addition to those available to the indemnifying
party, (3) a conflict or potential conflict exists (based on advice of counsel to the indemnified party) between the indemnified party
and the indemnifying party (in which case the indemnifying party will not have the right to direct the defense of such action on behalf
of the indemnified party) or (4) the indemnifying party has not in fact employed counsel reasonably satisfactory to the indemnified party
to assume the defense of such action within a reasonable time after receiving notice of the commencement of the action, in each of which
cases the reasonable fees, disbursements and other charges of counsel will be at the expense of the indemnifying party or parties. It
is understood that the indemnifying party or parties shall not, in connection with any proceeding or related proceedings in the same jurisdiction,
be liable for the reasonable fees, disbursements and other charges of more than one separate firm (plus local counsel) admitted to practice
in such jurisdiction at any one time for all such indemnified party or parties. All such fees, disbursements and other charges will be
reimbursed by the indemnifying party promptly after the indemnifying party receives a written invoice relating to such fees, disbursements
and other charges in reasonable detail. An indemnifying party will not, in any event, be liable for any settlement of any action or claim
effected without its written consent. No indemnifying party shall, without the prior written consent of each indemnified party, settle
or compromise or consent to the entry of any judgment in any pending or threatened claim, action or proceeding relating to the matters
contemplated by this Section 9 (whether or not any indemnified party is a party thereto), unless such settlement, compromise or consent
(1) includes an unconditional release of each indemnified party, in form and substance reasonably satisfactory to such indemnified party,
from all liability arising out of such claim, action or proceeding and (2) does not include a statement as to or an admission of fault,
culpability or a failure to act by or on behalf of any indemnified party.
(d) Settlement Without Consent if Failure to Reimburse. If
an indemnified party shall have requested an indemnifying party to reimburse the indemnified party for reasonable fees and expenses of
counsel for which it is entitled to be reimbursed under this Section 9, such indemnifying party agrees that it shall be liable for any
settlement of the nature contemplated by Section 9(a) effected without its written consent if (i) such settlement is entered into more
than 45 days after receipt by such indemnifying party of the aforesaid request, (ii) such indemnifying party shall have received notice
of the terms of such settlement at least 30 days prior to such settlement being entered into and (iii) such indemnifying party shall not
have reimbursed such indemnified party in accordance with such request prior to the date of such settlement.
(e) Contribution. In order to provide for just and equitable
contribution in circumstances in which the indemnification provided for in the foregoing paragraphs of this Section 9 is applicable in
accordance with its terms but for any reason is held to be unavailable or insufficient from the Company or the Agent, the Company and
the Agent will contribute to the total losses, claims, liabilities, expenses and damages (including any investigative, legal and other
expenses reasonably incurred in connection with, and any amount paid in settlement of, any action, suit, investigation or proceeding or
any claim asserted) to which the Company and the Agent may be subject in such proportion as shall be appropriate to reflect the relative
benefits received by the Company on the one hand and the Agent on the other hand. The relative benefits received by the Company on the
one hand and the Agent on the other hand shall be deemed to be in the same proportion as the total Net Proceeds from the sale of the Placement
Shares (before deducting expenses) received by the Company bear to the total compensation received by the Agent from the sale of Placement
Shares on behalf of the Company. If, but only if, the allocation provided by the foregoing sentence is not permitted by applicable law,
the allocation of contribution shall be made in such proportion as is appropriate to reflect not only the relative benefits referred to
in the foregoing sentence but also the relative fault of the Company, on the one hand, and the Agent, on the other hand, with respect
to the statements or omission that resulted in such loss, claim, liability, expense or damage, or action, suit, investigation or proceeding
in respect thereof, as well as any other relevant equitable considerations with respect to such offering. Such relative fault shall be
determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or omission or alleged
omission to state a material fact relates to information supplied by the Company or the Agent, the intent of the parties and their relative
knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and the Agent agree that
it would not be just and equitable if contributions pursuant to this Section 9(e) were to be determined by pro rata allocation
or by any other method of allocation that does not take into account the equitable considerations referred to herein. The amount paid
or payable by an indemnified party as a result of the loss, claim, liability, expense or damage, or action, suit, investigation or proceeding
in respect thereof, referred to above in this Section 9(e) shall be deemed to include, for the purpose of this Section 9(e), any legal
or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action, suit, investigation,
proceeding or claim to the extent consistent with this Section 9. Notwithstanding the foregoing provisions of this Section 9(e), the Agent
shall not be required to contribute any amount in excess of the commissions received by it under this Agreement and no person found guilty
of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any
person who was not guilty of such fraudulent misrepresentation. For purposes of this Section 9(e), any person who controls a party to
this Agreement within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, any affiliates of the Agent,
any partners, members, directors, officers, employees and agents of the Agent and each person that is controlled by or under common control
with the Agent will have the same rights to contribution as that party, and each officer of the Company who signed the Registration Statement
will have the same rights to contribution as the Company, subject in each case to the provisions hereof. Any party entitled to contribution,
promptly after receipt of notice of commencement of any action against such party in respect of which a claim for contribution may be
made under this Section 9(e), will notify any such party or parties from whom contribution may be sought, but the omission to so notify
will not relieve that party or parties from whom contribution may be sought from any other obligation it or they may have under this Section
9(e) except to the extent that the failure to so notify such other party materially prejudiced the substantive rights or defenses of the
party from whom contribution is sought. Except for a settlement entered into pursuant to the last sentence of Section 9(c) hereof or pursuant
to Section 9(d) hereof, no party will be liable for contribution with respect to any action or claim settled without its written consent
if such consent is required pursuant to Section 9(c) hereof.
10. Representations and Agreements to Survive Delivery. The
indemnity and contribution agreements contained in Section 9 of this Agreement and all representations and warranties of the Company herein
or in certificates delivered pursuant hereto shall survive, as of their respective dates, regardless of (i) any investigation made by
or on behalf of the Agent, any controlling persons, or the Company (or any of their respective officers, directors, employees or controlling
persons), (ii) delivery and acceptance of the Placement Shares and payment therefor or (iii) any termination of this Agreement.
11. Termination.
(a) The Agent shall have the right, by giving notice as hereinafter
specified, at any time to terminate this Agreement if (i) any Material Adverse Effect, or any development that could reasonably be expected
to result in a Material Adverse Effect, has occurred that, in the judgment of the Agent, may materially impair the ability of the Agent
to sell the Placement Shares hereunder, (ii) the Company shall have failed, refused or been unable to perform any agreement on its part
to be performed hereunder; provided, however, in the case of any failure of the Company to deliver (or cause another person
to deliver) any certification, opinion or letter required under Section 7(m), Section 7(n), Section 7(o) or Section 7(p), the Agent’s
right to terminate shall not arise unless such failure to deliver (or cause to be delivered) continues for more than 30 calendar days
from the date such delivery was required, (iii) any other condition of the Agent’s obligations hereunder is not fulfilled, (iv)
any suspension or limitation of trading in the Placement Shares or in securities generally on Nasdaq shall have occurred, (v) a general
banking moratorium shall have been declared by any of United States federal or New York authorities, or (vi) there shall have occurred
any outbreak or escalation of national or international hostilities or any crisis or calamity, or any change in the United States or international
financial markets, or any substantial change or development involving a prospective substantial change in United States or international
political, financial or economic conditions that, in the judgment of the Agent, may materially impair the ability of the Agent to sell
the Placement Shares hereunder or to enforce contracts for the sale of securities. Any such termination shall be without liability of
any party to any other party except that the provisions of Section 7(g), Section 9, Section 10, Section 16 and Section 17 hereof shall
remain in full force and effect notwithstanding such termination. If the Agent elects to terminate this Agreement as provided in this
Section 11(a), the Agent shall provide the required notice as specified in Section 12.
(b) The Company shall have the right, by giving five days’ prior
notice as hereinafter specified, to terminate this Agreement in its sole discretion at any time after the date of this Agreement. Any
such termination shall be without liability of any party to any other party except that the provisions of Section 7(g), Section 9, Section
10, Section 11(f), Section 16 and Section 17 hereof shall remain in full force and effect notwithstanding such termination.
(c) The Agent shall have the right, by giving five days’ prior
notice as hereinafter specified, to terminate this Agreement in its sole discretion at any time after the date of this Agreement. Any
such termination shall be without liability of any party to any other party except that the provisions of Section 7(g), Section 9, Section
10, Section 11(f), Section 16 and Section 17 hereof shall remain in full force and effect notwithstanding such termination.
(d) Unless earlier terminated pursuant to this Section 11, this Agreement
shall automatically terminate upon the issuance and sale of all of the Placement Shares through the Agent on the terms and subject to
the conditions set forth herein; provided that the provisions of Section 7(g), Section 9, Section 10, Section 11(f), Section 16
and Section 17 hereof shall remain in full force and effect notwithstanding such termination.
(e) This Agreement shall remain in full force and effect unless terminated
pursuant to Sections 11(a), (b), (c), or (d) above or otherwise by mutual agreement of the parties; provided, however, that
any such termination by mutual agreement shall in all cases be deemed to provide that Section 7(g), Section 9, Section 10, Section 11(f),
Section 16 and Section 17 shall remain in full force and effect.
(f) Any termination of this Agreement shall be effective on the date
specified in such notice of termination; provided, however, that such termination shall not be effective until the close of business
on the date of receipt of such notice by the Agent or the Company, as the case may be. If such termination shall occur prior to the Settlement
Date for any sale of Placement Shares, such Placement Shares shall settle in accordance with the provisions of this Agreement. Upon termination
of this Agreement, the Company shall not be required to pay to the Agent any discount or commission with respect to any Placement Shares
not otherwise sold by the Agent under this Agreement; provided, however, that the Company shall remain obligated to reimburse
the Agent’s expenses incurred through the date of termination pursuant to Section 7(g).
12. Notices. All notices or other communications required or
permitted to be given by any party to any other party pursuant to the terms of this Agreement shall be in writing, unless otherwise specified
in this Agreement, and if sent to the Agent, shall be delivered to:
Guggenheim Securities, LLC
330 Madison Avenue
New York, NY 10017
Attention: Jordan Bliss, with a copy to: General Counsel
E-mail: Jordan.Bliss@guggenheimpartners.com
with a copy (which shall not constitute notice) to:
Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
One Financial Center
Boston, MA 02111
Attention: William C. Hicks and John T. Rudy
Email: WCHicks@mintz.com and JRudy@mintz.com
and if to the Company, shall be delivered to:
Unicycive Therapeutics, Inc.
4300 El Camino Real, Suite #210
Los Altos, CA 94022
Attention: Shalabh Gupta
E-mail: Shalabh.Gupta@unicycive.com
with copies (which shall not constitute notice) to:
Sheppard, Mullin, Richter & Hampton LLP
30 Rockefeller Plaza
New York, NY 10112
Attention: Jeffrey Fessler
E-mail: JFessler@sheppardmullin.com
Each party to this Agreement may change such address for notices by
sending to the parties to this Agreement written notice of a new address for such purpose. Each such notice or other communication shall
be deemed given (i) when delivered personally on or before 4:30 P.M., New York City time, on a Business Day, or, if such day is not a
Business Day, on the next succeeding Business Day, (ii) by Electronic Notice as set forth in the next paragraph, (iii) on the next Business
Day after timely delivery to a nationally-recognized overnight courier or (iv) on the Business Day actually received if deposited in the
U.S. mail (certified or registered mail, return receipt requested, postage prepaid). For purposes of this Agreement, “Business
Day” shall mean any day on which the Nasdaq and commercial banks in the City of New York are open for business.
An electronic communication (“Electronic Notice”)
shall be deemed written notice for purposes of this Section 12 if sent to the electronic mail address specified by the receiving party
in Section 12. Electronic Notice shall be deemed received at the time the party sending Electronic Notice receives actual acknowledgment
of receipt from the person whom the notice is sent, other than via auto-reply. Any party receiving Electronic Notice may request and shall
be entitled to receive the notice on paper, in a nonelectronic form (“Nonelectronic Notice”), which shall be
sent to the requesting party within 10 days of receipt of the written request for Nonelectronic Notice.
13. Successors and Assigns. This Agreement shall inure to the
benefit of and be binding upon the Company and the Agent and their respective successors and the affiliates, controlling persons, officers,
directors and other persons referred to in Section 9 hereof. References to any of the parties contained in this Agreement shall be deemed
to include the successors and permitted assigns of each such party. Nothing in this Agreement, express or implied, is intended to confer
upon any party other than the parties hereto, the persons referred to in the preceding sentence and their respective successors and permitted
assigns any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement.
Neither party may assign its rights or obligations under this Agreement without the prior written consent of the other party; provided,
however, that the Agent may assign its rights and obligations hereunder to an affiliate of the Agent without obtaining the Company’s
consent, so long as such affiliate is a registered broker-dealer.
14. Adjustments for Share Splits. The parties acknowledge and
agree that all share-related numbers contained in this Agreement shall be adjusted to take into account any share split, share dividend
or similar event effected with respect to the Common Stock.
15. Entire Agreement; Amendment; Severability; Waiver. This
Agreement (including all schedules (as amended pursuant to this Agreement) and exhibits attached hereto and Placement Notices issued pursuant
hereto) constitutes the entire agreement and supersedes all other prior and contemporaneous agreements and undertakings, both written
and oral, among the parties hereto with regard to the subject matter hereof. Neither this Agreement nor any term hereof may be amended
except pursuant to a written instrument executed by the Company and the Agent; provided, however, that Schedule 2
of this Agreement may be amended by either party from time to time by sending a notice containing a revised Schedule 2 to
the other party in the manner provided in Section 12 and, upon such amendment, all references herein to Schedule 2 shall
automatically be deemed to refer to such amended Schedule 2. In the event that any one or more of the provisions contained
herein, or the application thereof in any circumstance, is held invalid, illegal or unenforceable as written by a court of competent jurisdiction,
then such provision shall be given full force and effect to the fullest possible extent that it is valid, legal and enforceable, and the
remainder of the terms and provisions herein shall be construed as if such invalid, illegal or unenforceable term or provision was not
contained herein, but only to the extent that giving effect to such provision and the remainder of the terms and provisions hereof shall
be in accordance with the intent of the parties as reflected in this Agreement. No implied waiver by a party shall arise in the absence
of a waiver in writing signed by such party. No failure or delay in exercising any right, power, or privilege hereunder shall operate
as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of
any right, power, or privilege hereunder.
16. GOVERNING LAW AND TIME; WAIVER OF JURY TRIAL. THIS AGREEMENT
SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS
OF LAWS. SPECIFIED TIMES OF DAY REFER TO NEW YORK CITY TIME. EACH PARTY HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY
APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS
CONTEMPLATED HEREBY.
17. Consent to Jurisdiction. Each party hereby irrevocably submits
to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan, for the adjudication
of any dispute hereunder or in connection with any of the transactions contemplated hereby, and hereby irrevocably waives, and agrees
not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that
such suit, action or proceeding is brought in an inconvenient forum, or that the venue of such suit, action or proceeding is improper.
Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding
by mailing a copy (certified or registered mail, return receipt requested) to such party at the address in effect for notices under Section
12 of this Agreement and agrees that such service shall constitute good and sufficient notice of process and notice thereof. Nothing contained
herein shall be deemed to limit in any way any right to serve process in any manner permitted by law.
18. Construction.
(a) The section and exhibit headings herein are for convenience only
and shall not affect the construction hereof.
(b) Words defined in the singular shall have a comparable meaning when
used in the plural, and vice versa.
(c) The words “hereof,” “hereto,” “herein”
and “hereunder” and words of similar import, when used in this Agreement, shall refer to this Agreement as a whole and not
to any particular provision of this Agreement.
(d) Wherever the word “include,” “includes”
or “including” is used in this Agreement, it shall be deemed to be followed by the words “without limitation.”
(e) References herein to any gender shall include each other gender.
(f) References herein to any law, statute, ordinance, code, regulation,
rule or other requirement of any governmental authority shall be deemed to refer to such law, statute, ordinance, code, regulation, rule
or other requirement of any governmental authority as amended, reenacted, supplemented or superseded in whole or in part and in effect
from time to time and also to all rules and regulations promulgated thereunder.
19. Permitted Free Writing Prospectuses. Each of the Company
and the Agent represents, warrants and agrees that, unless it obtains the prior written consent of the other party, which consent shall
not be unreasonably withheld, conditioned or delayed, it has not made and will not make any offer relating to the Placement Shares that
would constitute an issuer free writing prospectus, or that would otherwise constitute a free writing prospectus (as defined in Rule 405),
required to be filed with the Commission. Any such free writing prospectus consented to by the Agent or by the Company, as the case may
be, is hereinafter referred to as a “Permitted Free Writing Prospectus.” The Company represents and warrants
that it has treated and agrees that it will treat each Permitted Free Writing Prospectus as an issuer free writing prospectus, and that
it has complied and will comply with the requirements of Rule 433 applicable to any Permitted Free Writing Prospectus, including timely
filing with the Commission where required, legending and record keeping.
20. Absence of Fiduciary Relationship. The Company acknowledges
and agrees that:
(a) the Agent has been retained to act as sales agent in connection
with the sale of the Placement Shares, the Agent has acted at arms’ length and no fiduciary or advisory relationship between the
Company or any of its respective affiliates, stockholders (or other equity holders), creditors or employees or any other party, on the
one hand, and the Agent, on the other hand, has been or will be created in respect of any of the transactions contemplated by this Agreement,
irrespective of whether the Agent has advised or is advising the Company on other matters and the Agent has no duties or obligations to
the Company with respect to the transactions contemplated by this Agreement except the obligations expressly set forth herein;
(b) the Company is capable of evaluating, and understanding and understands
and accepts, the terms, risks and conditions of the transactions contemplated by this Agreement;
(c) neither the Agent nor its affiliates have provided any legal, accounting,
regulatory or tax advice with respect to the transactions contemplated by this Agreement and it has consulted its own legal, accounting,
regulatory and tax advisors to the extent it has deemed appropriate;
(d) the Company has been advised and is aware that the Agent and its
affiliates are engaged in a broad range of transactions which may involve interests that differ from those of the Company and that the
Agent and its affiliates have no obligation to disclose such interests and transactions to the Company by virtue of any fiduciary, advisory
or agency relationship or otherwise, provided that the Agent hereby agrees not to engage in any such transaction which would be prohibited
under Regulation M; and
(e) the Company waives, to the fullest extent permitted by law, any
claims it may have against the Agent or its affiliates for breach of fiduciary duty or alleged breach of fiduciary duty in connection
with the transactions contemplated by this Agreement and agrees that the Agent and its affiliates shall have no liability (whether direct
or indirect) to the Company in respect of such a fiduciary claim or to any person asserting a fiduciary duty claim on behalf of or in
right of the Company, including stockholders (or other equity holders), creditors or employees of the Company.
21. Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Delivery
of an executed Agreement by one party to the other may be made by facsimile or electronic transmission. Counterparts may be delivered
via facsimile, electronic mail (including any electronic signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions
Act, the Electronic Signatures and Records Act or other applicable law, e.g.,www.docusign.com) or other transmission method and any counterpart
so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.
22. Agent’s Information. As used in this Agreement, “Agent’s
Information” means solely the following information in the Registration Statement and the Prospectus: the first sentence
of the sixth paragraph and the ninth paragraph under the heading “Plan of Distribution” in the Prospectus Supplement.
All references in this Agreement to the Registration Statement, the
Prospectus or any amendment or supplement to any of the foregoing shall be deemed to include the copy filed with the Commission pursuant
to EDGAR. All references in this Agreement to financial statements and schedules and other information that is “contained,”
“included” or “stated” in the Registration Statement or the Prospectus (and all other references of like import)
shall be deemed to mean and include all such financial statements and schedules and other information that is incorporated by reference
in the Registration Statement or the Prospectus, as the case may be.
All references in this Agreement to “supplements” to the
Prospectus shall include any supplements, “wrappers” or similar materials prepared in connection with any offering, sale or
private placement of any Placement Shares by the Agent outside of the United States.
[Remainder of Page Intentionally Blank]
If the foregoing correctly sets forth the understanding between the
Company and the Agent, please so indicate in the space provided below for that purpose, whereupon this letter shall constitute a binding
agreement between the Company and the Agent.
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Very truly yours, |
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UNICYCIVE THERAPEUTICS, INC. |
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By: |
/s/ Shalabh Gupta |
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Name: |
Shalabh Gupta |
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Title: |
Chief Executive Officer |
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ACCEPTED as of the date first-above written: |
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GUGGENHEIM SECURITIES, LLC |
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By: |
/s/ Jordan Bliss |
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Name: |
Jordan Bliss |
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Title: |
Senior Managing Director |
[Signature Page to Sales Agreement]
SCHEDULE 1
FORM OF PLACEMENT NOTICE
From: |
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[ ] |
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[TITLE] |
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UNICYCIVE THERAPEUTICS, INC. |
Cc: |
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[ ] |
To: |
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Guggenheim Securities, LLC |
Subject: |
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Guggenheim Securities, LLC—At the Market Offering—Placement Notice |
Ladies and Gentlemen:
Pursuant to the terms and subject to the conditions contained in the
Sales Agreement, dated November 13, 2024 (the “Agreement”), by and between Unicycive Therapeutics, Inc., a Delaware
corporation (the “Company”), and Guggenheim Securities, LLC (“Guggenheim”), I hereby
request on behalf of the Company that Guggenheim sell up to [ ] shares of common stock, $0.001 par value per share, of the Company (the
“Shares”), at a minimum market price of $ per share [; provided that no more than [ ] Shares shall be
sold in any one Trading Day (as such term is defined in Section 3 of the Agreement)]. Sales should begin [on the date of this Placement
Notice] and end on [DATE] [until all Shares that are the subject of this Placement Notice are sold].
SCHEDULE 2
The Company
Shalabh Gupta - Shalabh Gupta <Shalabh.Gupta@unicycive.com>
John Townsend - John Townsend <john.townsend@unicycive.com>
Guggenheim Securities, LLC
Jordan Bliss – Jordan.Bliss@guggenheimpartners.com
Eric Guzman – Eric.Guzman@guggenheimpartners.com
James Lee - James.Lee@guggenheimpartners.com
Michael Jiang - Michael.Jiang@guggenheimpartners.com
SCHEDULE 3
Compensation
The Company shall pay Guggenheim Securities, LLC compensation in cash
equal to 3.0% of the gross proceeds from the sales of Placement Shares pursuant to the terms of the Sales Agreement of which this Schedule
3 forms a part.
Exhibit 7(m)
OFFICERS’ CERTIFICATE
Each of Shalabh Gupta, the duly qualified
and elected Chief Executive Officer of Unicycive Therapeutics, Inc., a Delaware corporation (the “Company”),
and John Townsend, the duly qualified and elected Chief Financial Officer of the Company, does hereby certify in his respective capacity
and on behalf of the Company, pursuant to Section 7(m) of the Sales Agreement, dated November 13, 2024 (the “Sales Agreement”),
by and between the Company and Guggenheim Securities, LLC, that, after due inquiry, to the best of the knowledge of the undersigned:
(i)
The representations and warranties of the Company in Section 6 of the Sales Agreement (A) to the extent such
representations and warranties are subject to qualifications and exceptions contained therein relating to materiality or Material
Adverse Effect, are true and correct on and as of the date hereof with the same force and effect as if expressly made on and as of
the date hereof, and (B) to the extent such representations and warranties are not subject to any qualifications or exceptions
relating to materiality or Material Adverse Effect, are true and correct in all material respects as of the date hereof as if made
on and as of the date hereof with the same force and effect as if expressly made on and as of the date hereof.
(ii)
The Company has complied with all agreements and satisfied all conditions on its part to be performed or satisfied pursuant to the
Sales Agreement at or prior to the date hereof.
(iii)
As of the date hereof, (A) the Registration Statement complies in all material respects with the requirements of the Securities
Act and does not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary in order to make the statements therein not misleading, (B) the Prospectus complies in all material respects with the
requirements of the Securities Act does not contain any untrue statement of a material fact or omit to state a material fact
required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they
were made, not misleading and (C) no event has occurred as a result of which it is necessary to amend or supplement the
Registration Statement or the Prospectus in order to make the statements therein not untrue or misleading or for clauses
(A) and (B) above, to be true and correct.
(iv)
There has been no material adverse change, or any development that could reasonably be expected to result in a material adverse
change, in the condition (financial or otherwise), earnings, results of operations, business, properties, operations, assets,
liabilities or prospects of the Company, taken as a whole, whether or not arising from transactions in the ordinary course of
business, since the date as of which information is given in the Prospectus, as amended or supplemented to the date hereof.
(v)
The Company does not possess any material non-public information.
(vi)
The maximum amount of Placement Shares that may be sold pursuant to the Sales Agreement has been duly authorized by the
Company’s board of directors or a duly authorized committee thereof pursuant to a resolution or unanimous written consent in
accordance with the Company’s amended and restated articles of incorporation, amended and restated bylaws and applicable
law.
Capitalized terms used
but not defined herein shall have the meanings ascribed to them in the Sales Agreement.
IN WITNESS WHEREOF, each
of the undersigned, in such individual’s respective capacity as Chief Executive Officer or Chief Financial Officer of the Company,
has executed this Officers’ Certificate on behalf of the Company.
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Name: |
Shalabh Gupta |
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Title: |
Chief Executive Officer, President and Chairman |
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Date: |
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By: |
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Name: |
John Townsend |
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Title: |
Chief Financial Officer |
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Date: |
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Exhibit 4.3
UNICYCIVE THERAPEUTICS, INC.,
ISSUER
AND
[TRUSTEE],
TRUSTEE
INDENTURE
DATED AS OF , 20__
SENIOR DEBT SECURITIES
TABLE OF CONTENTS
|
|
Page |
ARTICLE I DEFINITIONS |
1 |
Section 1.1 |
Definitions of Terms |
1 |
ARTICLE II ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES |
4 |
Section 2.1 |
Designation and Terms of Securities |
4 |
Section 2.2 |
Form of Securities and Trustee’s Certificate |
5 |
Section 2.3 |
Denominations: Provisions for Payment |
5 |
Section 2.4 |
Execution and Authentications |
6 |
Section 2.5 |
Registration of Transfer and Exchange |
7 |
Section 2.6 |
Temporary Securities |
8 |
Section 2.7 |
Mutilated, Destroyed, Lost or Stolen Securities |
8 |
Section 2.8 |
Cancellation |
8 |
Section 2.9 |
Benefits of Indenture |
9 |
Section 2.10 |
Authenticating Agent |
9 |
Section 2.11 |
Global Securities |
9 |
ARTICLE III REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS |
10 |
Section 3.1 |
Redemption |
10 |
Section 3.2 |
Notice of Redemption |
10 |
Section 3.3 |
Payment Upon Redemption |
11 |
Section 3.4 |
Sinking Fund |
11 |
Section 3.5 |
Satisfaction of Sinking Fund Payments with Securities |
11 |
Section 3.6 |
Redemption of Securities for Sinking Fund |
11 |
ARTICLE IV COVENANTS |
12 |
Section 4.1 |
Payment of Principal, Premium and Interest |
12 |
Section 4.2 |
Maintenance of Office or Agency |
12 |
Section 4.3 |
Paying Agents |
12 |
Section 4.4 |
Appointment to Fill Vacancy in Office of Trustee |
13 |
Section 4.5 |
Compliance with Consolidation Provisions |
13 |
ARTICLE V SECURITYHOLDERS’ LISTS AND REPORTS BY THE COMPANY AND THE TRUSTEE |
13 |
Section 5.1 |
Company to Furnish Trustee Names and Addresses of Securityholders |
13 |
Section 5.2 |
Preservation Of Information; Communications With Securityholders |
13 |
Section 5.3 |
Reports by the Company |
13 |
Section 5.4 |
Reports by the Trustee |
14 |
ARTICLE VI REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT |
14 |
Section 6.1 |
Events of Default |
14 |
Section 6.2 |
Collection of Indebtedness and Suits for Enforcement by Trustee |
15 |
Section 6.3 |
Application of Moneys Collected |
16 |
Section 6.4 |
Limitation on Suits |
16 |
Section 6.5 |
Rights and Remedies Cumulative; Delay or Omission Not Waiver |
17 |
Section 6.6 |
Control by Securityholders |
17 |
Section 6.7 |
Undertaking to Pay Costs |
17 |
ARTICLE VII CONCERNING THE TRUSTEE |
18 |
Section 7.1 |
Certain Duties and Responsibilities of Trustee |
18 |
Section 7.2 |
Certain Rights of Trustee |
18 |
Section 7.3 |
Trustee Not Responsible for Recitals or Issuance or Securities |
19 |
Section 7.4 |
May Hold Securities |
19 |
Section 7.5 |
Moneys Held in Trust |
19 |
Section 7.6 |
Compensation and Reimbursement |
20 |
Section 7.7 |
Reliance on Officer’s Certificate |
20 |
Section 7.8 |
Disqualification; Conflicting Interests |
20 |
Section 7.9 |
Corporate Trustee Required; Eligibility |
20 |
Section 7.10 |
Resignation and Removal; Appointment of Successor |
20 |
Section 7.11 |
Acceptance of Appointment By Successor |
21 |
Section 7.12 |
Merger, Conversion, Consolidation or Succession to Business |
22 |
Section 7.13 |
Preferential Collection of Claims Against the Company |
22 |
Section 7.14 |
Notice of Default |
22 |
ARTICLE VIII CONCERNING THE SECURITYHOLDERS |
23 |
Section 8.1 |
Evidence of Action by Securityholders |
23 |
Section 8.2 |
Proof of Execution by Securityholders |
23 |
Section 8.3 |
Who May be Deemed Owners |
23 |
Section 8.4 |
Certain Securities Owned by Company Disregarded |
23 |
Section 8.5 |
Actions Binding on Future Securityholders |
24 |
ARTICLE IX SUPPLEMENTAL INDENTURES |
24 |
Section 9.1 |
Supplemental Indentures Without the Consent of Securityholders |
24 |
Section 9.2 |
Supplemental Indentures With Consent of Securityholders |
25 |
Section 9.3 |
Effect of Supplemental Indentures |
25 |
Section 9.4 |
Securities Affected by Supplemental Indentures |
25 |
Section 9.5 |
Execution of Supplemental Indentures |
25 |
ARTICLE X SUCCESSOR ENTITY |
26 |
Section 10.1 |
Company May Consolidate, Etc |
26 |
Section 10.2 |
Successor Entity Substituted |
26 |
Section 10.3 |
Evidence of Consolidation, Etc |
26 |
ARTICLE XI SATISFACTION AND DISCHARGE |
27 |
Section 11.1 |
Satisfaction and Discharge of Indenture |
27 |
Section 11.2 |
Discharge of Obligations |
27 |
Section 11.3 |
Deposited Moneys to be Held in Trust |
27 |
Section 11.4 |
Payment of Moneys Held by Paying Agents |
27 |
Section 11.5 |
Repayment to Company |
28 |
ARTICLE XII IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS AND DIRECTORS |
28 |
Section 12.1 |
No Recourse |
28 |
ARTICLE XIII MISCELLANEOUS PROVISIONS |
28 |
Section 13.1 |
Effect on Successors and Assigns |
28 |
Section 13.2 |
Actions by Successor |
28 |
Section 13.3 |
Surrender of Company Powers |
28 |
Section 13.4 |
Notices |
28 |
Section 13.5 |
Governing Law |
29 |
Section 13.6 |
Treatment of Securities as Debt |
29 |
Section 13.7 |
Certificates and Opinions as to Conditions Precedent |
29 |
Section 13.8 |
Payments on Business Days |
29 |
Section 13.9 |
Conflict with Trust Indenture Act |
29 |
Section 13.10 |
Counterparts |
29 |
Section 13.11 |
Separability |
29 |
Section 13.12 |
Compliance Certificates |
29 |
INDENTURE
INDENTURE,
dated as of [●], among Unicycive Therapeutics, Inc., a Delaware corporation (the “Company”), and [TRUSTEE], as trustee
(the “Trustee”):
WHEREAS,
for its lawful corporate purposes, the Company has duly authorized the execution and delivery of this Indenture to provide for the issuance
of debt securities (hereinafter referred to as the “Securities”), in an unlimited aggregate principal amount to be issued from
time to time in one or more series as in this Indenture provided, as registered Securities without coupons, to be authenticated by the
certificate of the Trustee;
WHEREAS,
to provide the terms and conditions upon which the Securities are to be authenticated, issued and delivered, the Company has duly authorized
the execution of this Indenture; and
WHEREAS,
all things necessary to make this Indenture a valid agreement of the Company, in accordance with its terms, have been done.
NOW,
THEREFORE, in consideration of the premises and the purchase of the Securities by the holders thereof, it is mutually covenanted and
agreed as follows for the equal and ratable benefit of the holders of Securities:
ARTICLE
I
DEFINITIONS
Section
1.1 Definitions of Terms.
The terms defined in this Section (except as in
this Indenture or any indenture supplemental hereto otherwise expressly provided or unless the context otherwise requires) for all purposes
of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section and shall include
the plural as well as the singular. All other terms used in this Indenture that are defined in the Trust Indenture Act of 1939, as amended,
or that are by reference in such Act defined in the Securities Act of 1933, as amended (except as herein or any indenture supplemental
hereto otherwise expressly provided or unless the context otherwise requires), shall have the meanings assigned to such terms in said
Trust Indenture Act and in said Securities Act as in force at the date of the execution of this instrument.
“Authenticating Agent” means an authenticating
agent with respect to all or any of the series of Securities appointed by the Trustee pursuant to Section 2.10.
“Bankruptcy Law” means Title 11, U.S.
Code, or any similar federal or state law for the relief of debtors.
“Board of Directors” means the Board
of Directors of the Company or any duly authorized committee of such Board.
“Board Resolution” means a copy of a
resolution certified by the Secretary or an Assistant Secretary of the Company to have been duly adopted by the Board of Directors and
to be in full force and effect on the date of such certification.
“Business Day” means, with respect to
any series of Securities, any day other than a day on which federal or state banking institutions in the Borough of Manhattan, the City
of New York, or in the city of the Corporate Trust Office of the Trustee, are authorized or obligated by law, executive order or regulation
to close.
“Certificate” means a certificate signed
by any Officer. The Certificate need not comply with the provisions of Section 13.07.
“Company” means Unicycive Therapeutics,
Inc., a corporation duly organized and existing under the laws of the State of Delaware, and, subject to the provisions of Article Ten,
shall also include its successors and assigns.
“Corporate Trust Office” means the office
of the Trustee at which, at any particular time, its corporate trust business shall be principally administered, which office at the date
hereof is located at .
“Custodian” means any receiver, trustee,
assignee, liquidator or similar official under any Bankruptcy Law.
“Default” means any event, act or condition
that with notice or lapse of time, or both, would constitute an Event of Default.
“Defaulted Interest” has the meaning
set forth in Section 2.03.
“Depositary” means, with respect to
Securities of any series for which the Company shall determine that such Securities will be issued as a Global Security, The Depository
Trust Company, another clearing agency, or any successor registered as a clearing agency under the Exchange Act, or other applicable statute
or regulation, which, in each case, shall be designated by the Company pursuant to either Section 2.01 or 2.11.
“Event of Default” means, with respect
to Securities of a particular series, any event specified in Section 6.01, continued for the period of time, if any, therein designated.
“Exchange Act” means the Securities
and Exchange Act of 1934, as amended.
“Global Security” means, with respect
to any series of Securities, a Security executed by the Company and delivered by the Trustee to the Depositary or pursuant to the Depositary’s
instruction, all in accordance with the Indenture, which shall be registered in the name of the Depositary or its nominee.
“Governmental Obligations” means securities
that are (a) direct obligations of the United States of America for the payment of which its full faith and credit is pledged or (b) obligations
of a Person controlled or supervised by and acting as an agency or instrumentality of the United States of America, the payment of which
is unconditionally guaranteed as a full faith and credit obligation by the United States of America that, in either case, are not callable
or redeemable at the option of the issuer thereof at any time prior to the stated maturity of the Securities, and shall also include a
depositary receipt issued by a bank or trust company as custodian with respect to any such Governmental Obligation or a specific payment
of principal of or interest on any such Governmental Obligation held by such custodian for the account of the holder of such depositary
receipt; provided, however, that (except as required by law) such custodian is not authorized to make any deduction from the amount payable
to the holder of such depositary receipt from any amount received by the custodian in respect of the Governmental Obligation or the specific
payment of principal of or interest on the Governmental Obligation evidenced by such depositary receipt.
“herein”, “hereof” and “hereunder”,
and other words of similar import, refer to this Indenture as a whole and not to any particular Article, Section or other subdivision.
“Indenture” means this instrument as
originally executed or as it may from time to time be supplemented or amended by one or more indentures supplemental hereto entered into
in accordance with the terms hereof.
“Interest Payment Date”, when used with
respect to any installment of interest on a Security of a particular series, means the date specified in such Security or in a Board Resolution
or in an indenture supplemental hereto with respect to such series as the fixed date on which an installment of interest with respect
to Securities of that series is due and payable.
“Officer” means, with respect to the
Company, the chairman of the Board of Directors, a chief executive officer, a president, a chief financial officer, a chief operating
officer, any executive vice president, any senior vice president, any vice president, the treasurer or any assistant treasurer, the controller
or any assistant controller or the secretary or any assistant secretary.
“Officer’s Certificate” means a certificate
signed by any Officer. Each such certificate shall include the statements provided for in Section 13.07, if and to the extent required
by the provisions thereof.
“Opinion of Counsel” means an opinion
in writing subject to customary exceptions of legal counsel, who may be an employee of or counsel for the Company, that is delivered to
the Trustee in accordance with the terms hereof. Each such opinion shall include the statements provided for in Section 13.07, if and
to the extent required by the provisions thereof.
“Outstanding”, when used with
reference to Securities of any series, means, subject to the provisions of Section 8.04, as of any particular time, all Securities
of that series theretofore authenticated and delivered by the Trustee under this Indenture, except (a) Securities theretofore
canceled by the Trustee or any paying agent, or delivered to the Trustee or any paying agent for cancellation or that have
previously been canceled; (b) Securities or portions thereof for the payment or redemption of which moneys or Governmental
Obligations in the necessary amount shall have been deposited in trust with the Trustee or with any paying agent (other than the
Company) or shall have been set aside and segregated in trust by the Company (if the Company shall act as its own paying agent);
provided, however, that if such Securities or portions of such Securities are to be redeemed prior to the maturity thereof, notice
of such redemption shall have been given as provided in Article Three, or provision satisfactory to the Trustee shall have been made
for giving such notice; and (c) Securities in lieu of or in substitution for which other Securities shall have been authenticated
and delivered pursuant to the terms of Section 2.07.
“Person” means any individual, corporation,
partnership, joint venture, joint-stock company, limited liability company, association, trust, unincorporated organization, any other
entity or organization, including a government or political subdivision or an agency or instrumentality thereof.
“Predecessor Security” of any particular
Security means every previous Security evidencing all or a portion of the same debt as that evidenced by such particular Security; and,
for the purposes of this definition, any Security authenticated and delivered under Section 2.07 in lieu of a lost, destroyed or stolen
Security shall be deemed to evidence the same debt as the lost, destroyed or stolen Security.
“Responsible Officer” when used with
respect to the Trustee means the chairman of its board of directors, the chief executive officer, the president, any vice president, the
secretary, the treasurer, any trust officer, any corporate trust officer or any other officer or assistant officer of the Trustee customarily
performing functions similar to those performed by the Persons who at the time shall be such officers, respectively, or to whom any corporate
trust matter is referred because of his or her knowledge of and familiarity with the particular subject.
“Securities” means the debt Securities
authenticated and delivered under this Indenture.
“Securityholder”, “holder of Securities”,
“registered holder”, or other similar term, means the Person or Persons in whose name or names a particular Security shall be
registered on the books of the Company kept for that purpose in accordance with the terms of this Indenture.
“Security Register” and “Security
Registrar” shall have the meanings as set forth in Section 2.05.
“Subsidiary” means, with respect to
any Person, (i) any corporation at least a majority of whose outstanding Voting Stock shall at the time be owned, directly or indirectly,
by such Person or by one or more of its Subsidiaries or by such Person and one or more of its Subsidiaries, (ii) any general partnership,
joint venture or similar entity, at least a majority of whose outstanding partnership or similar interests shall at the time be owned
by such Person, or by one or more of its Subsidiaries, or by such Person and one or more of its Subsidiaries and (iii) any limited partnership
of which such Person or any of its Subsidiaries is a general partner.
“Trustee” means , and, subject to the
provisions of Article Seven, shall also include its successors and assigns, and, if at any time there is more than one Person acting in
such capacity hereunder, “Trustee” shall mean each such Person. The term “Trustee” as used with respect to a particular
series of the Securities shall mean the trustee with respect to that series.
“Trust Indenture Act” means the Trust
Indenture Act of 1939, as amended.
“Voting Stock”, as applied to stock
of any Person, means shares, interests, participations or other equivalents in the equity interest (however designated) in such Person
having ordinary voting power for the election of a majority of the directors (or the equivalent) of such Person, other than shares, interests,
participations or other equivalents having such power only by reason of the occurrence of a contingency.
ARTICLE II
ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION
AND EXCHANGE OF SECURITIES
Section 2.1 Designation and Terms of Securities.
(a) The aggregate principal amount of Securities
that may be authenticated and delivered under this Indenture is unlimited. The Securities may be issued in one or more series up to the
aggregate principal amount of Securities of that series from time to time authorized by or pursuant to a Board Resolution or pursuant
to one or more indentures supplemental hereto. Prior to the initial issuance of Securities of any series, there shall be established in
or pursuant to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental hereto:
(i) the title of the Securities of the series (which
shall distinguish the Securities of that series from all other Securities);
(ii) any limit upon the aggregate principal amount
of the Securities of that series that may be authenticated and delivered under this Indenture (except for Securities authenticated and
delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities of that series);
(iii) the date or dates on which the principal of
the Securities of the series is payable, any original issue discount that may apply to the Securities of that series upon their issuance,
the principal amount due at maturity, and the place(s) of payment;
(iv) the rate or rates at which the Securities of
the series shall bear interest or the manner of calculation of such rate or rates, if any;
(v) the date or dates from which such interest shall
accrue, the Interest Payment Dates on which such interest will be payable or the manner of determination of such Interest Payment Dates,
the place(s) of payment, and the record date for the determination of holders to whom interest is payable on any such Interest Payment
Dates or the manner of determination of such record dates;
(vi) the right, if any, to extend the interest payment
periods and the duration of such extension;
(vii) the period or periods within which, the price
or prices at which and the terms and conditions upon which Securities of the series may be redeemed, in whole or in part, at the option
of the Company;
(viii) the obligation, if any, of the Company to
redeem or purchase Securities of the series pursuant to any sinking fund, mandatory redemption, or analogous provisions (including payments
made in cash in satisfaction of future sinking fund obligations) or at the option of a holder thereof and the period or periods within
which, the price or prices at which, and the terms and conditions upon which, Securities of the series shall be redeemed or purchased,
in whole or in part, pursuant to such obligation;
(ix) the form of the Securities of the series including
the form of the Certificate of Authentication for such series;
(x) if other than denominations of one thousand
U.S. dollars ($1,000) or any integral multiple thereof, the denominations in which the Securities of the series shall be issuable;
(xi) any and all other terms (including terms, to
the extent applicable, relating to any auction or remarketing of the Securities of that series and any security for the obligations of
the Company with respect to such Securities) with respect to such series (which terms shall not be inconsistent with the terms of this
Indenture, as amended by any supplemental indenture) including any terms which may be required by or advisable under United States laws
or regulations or advisable in connection with the marketing of Securities of that series;
(xii) whether the Securities are issuable as a Global
Security and, in such case, the terms and the identity of the Depositary for such series;
(xiii) whether the Securities will be convertible
into or exchangeable for shares of common stock, preferred stock or other securities of the Company or any other Person and, if so, the
terms and conditions upon which such Securities will be so convertible or exchangeable, including the conversion or exchange price, as
applicable, or how it will be calculated and may be adjusted, any mandatory or optional (at the Company’s option or the holders’ option)
conversion or exchange features, and the applicable conversion or exchange period;
(xiv) if other than the principal amount thereof,
the portion of the principal amount of Securities of the series which shall be payable upon declaration of acceleration of the maturity
thereof pursuant to Section 6.01;
(xv) any additional or different Events of Default
or restrictive covenants (which may include, among other restrictions, restrictions on the Company’s ability or the ability of the Company’s
Subsidiaries to: incur additional indebtedness; issue additional securities; create liens; pay dividends or make distributions in respect
of the capital stock of the Company or the Company’s Subsidiaries; redeem capital stock; place restrictions on the Company’s Subsidiaries’
ability to pay dividends, make distributions or transfer assets; make investments or other restricted payments; sell or otherwise dispose
of assets; enter into sale- leaseback transactions; engage in transactions with stockholders or affiliates; issue or sell stock of the
Company’s Subsidiaries; or effect a consolidation or merger) or financial covenants (which may include, among other financial covenants,
financial covenants that require the Company and its Subsidiaries to maintain specified interest coverage, fixed charge, cash flow-based,
asset-based or other financial ratios) provided for with respect to the Securities of the series;
(xvi) if other than dollars, the coin or currency
in which the Securities of the series are denominated (including, but not limited to, foreign currency);
(xvii) the terms and conditions, if any, upon which
the Company shall pay amounts in addition to the stated interest, premium, if any and principal amounts of the Securities of the series
to any Securityholder that is not a “United States person” for federal tax purposes; and
(xviii) any restrictions on transfer, sale or assignment
of the Securities of the series.
All Securities of any one series shall be substantially
identical except as may otherwise be provided in or pursuant to any such Board Resolution or in any indentures supplemental hereto.
If any of the terms of the series are established
by action taken pursuant to a Board Resolution of the Company, a copy of an appropriate record of such action shall be certified by the
secretary or an assistant secretary of the Company and delivered to the Trustee at or prior to the delivery of the Officer’s Certificate
of the Company setting forth the terms of the series.
Securities of any particular series may be issued
at various times, with different dates on which the principal or any installment of principal is payable, with different rates of interest,
if any, or different methods by which rates of interest may be determined, with different dates on which such interest may be payable
and with different redemption dates.
Section 2.2 Form of Securities and Trustee’s
Certificate.
The Securities of any series and the Trustee’s
certificate of authentication to be borne by such Securities shall be substantially of the tenor and purport as set forth in one or more
indentures supplemental hereto or as provided in a Board Resolution, and set forth in an Officer’s Certificate, and they may have such
letters, numbers or other marks of identification or designation and such legends or endorsements printed, lithographed or engraved thereon
as the Company may deem appropriate and as are not inconsistent with the provisions of this Indenture, or as may be required to comply
with any law or with any rule or regulation made pursuant thereto or with any rule or regulation of any securities exchange on which Securities
of that series may be listed, or to conform to usage.
Section 2.3 Denominations: Provisions for Payment.
The Securities shall be issuable as registered
Securities and in the denominations of one thousand U.S. dollars ($1,000) or any integral multiple thereof, subject to Section 2.01(a)(10).
The Securities of a particular series shall bear
interest payable on the dates and at the rate specified with respect to that series. Subject to Section 2.01(a)(16), the principal of
and the interest on the Securities of any series, as well as any premium thereon in case of redemption thereof prior to maturity, shall
be payable in the coin or currency of the United States of America that at the time is legal tender for public and private debt, at the
office or agency of the Company maintained for that purpose.
Each Security shall be dated the date of its authentication. Interest
on the Securities shall be computed on the basis of a 360-day year composed of twelve 30-day months.
The interest installment on any Security that
is payable, and is punctually paid or duly provided for, on any Interest Payment Date for Securities of that series shall be paid to the
Person in whose name said Security (or one or more Predecessor Securities) is registered at the close of business on the regular record
date for such interest installment. In the event that any Security of a particular series or portion thereof is called for redemption
and the redemption date is subsequent to a regular record date with respect to any Interest Payment Date and prior to such Interest Payment
Date, interest on such Security will be paid upon presentation and surrender of such Security as provided in Section 3.03.
Any interest on any Security that is payable,
but is not punctually paid or duly provided for, on any Interest Payment Date for Securities of the same series (herein called “Defaulted
Interest”) shall forthwith cease to be payable to the registered holder on the relevant regular record date by virtue of having been
such holder; and such Defaulted Interest shall be paid by the Company, at its election, as provided in clause (1) or clause (2) below:
(i) The Company may make payment of any Defaulted
Interest on Securities to the Persons in whose names such Securities (or their respective Predecessor Securities) are registered at the
close of business on a special record date for the payment of such Defaulted Interest, which shall be fixed in the following manner: the
Company shall notify the Trustee in writing of the amount of Defaulted Interest proposed to be paid on each such Security and the date
of the proposed payment, and at the same time the Company shall deposit with the Trustee an amount of money equal to the aggregate amount
proposed to be paid in respect of such Defaulted Interest or shall make arrangements satisfactory to the Trustee for such deposit prior
to the date of the proposed payment, such money when deposited to be held in trust for the benefit of the Persons entitled to such Defaulted
Interest as in this clause provided. Thereupon the Trustee shall fix a special record date for the payment of such Defaulted Interest
which shall not be more than 15 nor less than 10 days prior to the date of the proposed payment and not less than 10 days after the receipt
by the Trustee of the notice of the proposed payment. The Trustee shall promptly notify the Company of such special record date and, in
the name and at the expense of the Company, shall cause notice of the proposed payment of such Defaulted Interest and the special record
date therefor to be mailed, first class postage prepaid, to each Securityholder at his or her address as it appears in the Security Register
(as hereinafter defined), not less than 10 days prior to such special record date. Notice of the proposed payment of such Defaulted Interest
and the special record date therefor having been mailed as aforesaid, such Defaulted Interest shall be paid to the Persons in whose names
such Securities (or their respective Predecessor Securities) are registered on such special record date.
(ii) The Company may make payment of any Defaulted
Interest on any Securities in any other lawful manner not inconsistent with the requirements of any securities exchange on which such
Securities may be listed, and upon such notice as may be required by such exchange, if, after notice given by the Company to the Trustee
of the proposed payment pursuant to this clause, such manner of payment shall be deemed practicable by the Trustee.
Unless otherwise set forth in a Board Resolution
or one or more indentures supplemental hereto establishing the terms of any series of Securities pursuant to Section 2.01 hereof, the
term “regular record date” as used in this Section with respect to a series of Securities and any Interest Payment Date for
such series shall mean either the fifteenth day of the month immediately preceding the month in which an Interest Payment Date established
for such series pursuant to Section 2.01 hereof shall occur, if such Interest Payment Date is the first day of a month, or the first day
of the month in which an Interest Payment Date established for such series pursuant to Section 2.01 hereof shall occur, if such Interest
Payment Date is the fifteenth day of a month, whether or not such date is a Business Day.
Subject to the foregoing provisions of this Section,
each Security of a series delivered under this Indenture upon transfer of or in exchange for or in lieu of any other Security of such
series shall carry the rights to interest accrued and unpaid, and to accrue, that were carried by such other Security.
Section 2.4 Execution and Authentications.
The Securities shall be signed on behalf of the
Company by one of its Officers. Signatures may be in the form of a manual or facsimile signature.
The Company may use the facsimile signature of
any Person who shall have been an Officer, notwithstanding the fact that at the time the Securities shall be authenticated and delivered
or disposed of such Person shall have ceased to be such an officer of the Company. The Securities may contain such notations, legends
or endorsements required by law, stock exchange rule or usage. Each Security shall be dated the date of its authentication by the Trustee.
A Security shall not be valid until authenticated
manually by an authorized signatory of the Trustee, or by an Authenticating Agent. Such signature shall be conclusive evidence that the
Security so authenticated has been duly authenticated and delivered hereunder and that the holder is entitled to the benefits of this
Indenture. At any time and from time to time after the execution and delivery of this Indenture, the Company may deliver Securities of
any series executed by the Company to the Trustee for authentication, together with a written order of the Company for the authentication
and delivery of such Securities, signed by an Officer, and the Trustee in accordance with such written order shall authenticate and deliver
such Securities.
In authenticating such Securities and accepting
the additional responsibilities under this Indenture in relation to such Securities, the Trustee shall be entitled to receive, if requested,
and (subject to Section 7.01) shall be fully protected in relying upon, an Opinion of Counsel stating that the form and terms thereof
have been established in conformity with the provisions of this Indenture.
The Trustee shall not be required to authenticate
such Securities if the issue of such Securities pursuant to this Indenture will affect the Trustee’s own rights, duties or immunities
under the Securities and this Indenture or otherwise in a manner that is not reasonably acceptable to the Trustee.
Section 2.5 Registration of Transfer and Exchange.
(a) Securities of any series may be exchanged
upon presentation thereof at the office or agency of the Company designated for such purpose, for other Securities of such series of authorized
denominations, and for a like aggregate principal amount, upon payment of a sum sufficient to cover any tax or other governmental charge
in relation thereto, all as provided in this Section. In respect of any Securities so surrendered for exchange, the Company shall execute,
the Trustee shall authenticate and such office or agency shall deliver in exchange therefor the Security or Securities of the same series
that the Securityholder making the exchange shall be entitled to receive, bearing numbers not contemporaneously outstanding.
(b) The Company shall keep, or cause to be kept,
at its office or agency designated for such purpose a register or registers (herein referred to as the “Security Register”)
in which, subject to such reasonable regulations as it may prescribe, the Company shall register the Securities and the transfers of Securities
as in this Article provided and which at all reasonable times shall be open for inspection by the Trustee. The registrar for the purpose
of registering Securities and transfer of Securities as herein provided shall be appointed as authorized by Board Resolution (the “Security
Registrar”).
Upon surrender for transfer of any Security at
the office or agency of the Company designated for such purpose, the Company shall execute, the Trustee shall authenticate and such office
or agency shall deliver in the name of the transferee or transferees a new Security or Securities of the same series as the Security presented
for a like aggregate principal amount.
All Securities presented or surrendered for exchange
or registration of transfer, as provided in this Section, shall be accompanied (if so required by the Company or the Security Registrar)
by a written instrument or instruments of transfer, in form satisfactory to the Company or the Security Registrar, duly executed by the
registered holder or by such holder’s duly authorized attorney in writing.
(c) Except as provided pursuant to Section 2.01
pursuant to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental to this
Indenture, no service charge shall be made for any exchange or registration of transfer of Securities, or issue of new Securities in case
of partial redemption of any series, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge
in relation thereto, other than exchanges pursuant to Section 2.06, Section 3.03(b) and Section 9.04 not involving any transfer.
(d) The Company shall not be required (i) to issue,
exchange or register the transfer of any Securities during a period beginning at the opening of business 15 days before the day of the
mailing of a notice of redemption of less than all the Outstanding Securities of the same series and ending at the close of business on
the day of such mailing, nor (ii) to register the transfer of or exchange any Securities of any series or portions thereof called for
redemption, other than the unredeemed portion of any such Securities being redeemed in part. The provisions of this Section 2.05 are,
with respect to any Global Security, subject to Section 2.11 hereof.
Section 2.6 Temporary Securities.
Pending the preparation of definitive Securities
of any series, the Company may execute, and the Trustee shall authenticate and deliver, temporary Securities (printed, lithographed or
typewritten) of any authorized denomination. Such temporary Securities shall be substantially in the form of the definitive Securities
in lieu of which they are issued, but with such omissions, insertions and variations as may be appropriate for temporary Securities, all
as may be determined by the Company. Every temporary Security of any series shall be executed by the Company and be authenticated by the
Trustee upon the same conditions and in substantially the same manner, and with like effect, as the definitive Securities of such series.
Without unnecessary delay the Company will execute and will furnish definitive Securities of such series and thereupon any or all temporary
Securities of such series may be surrendered in exchange therefor (without charge to the holders), at the office or agency of the Company
designated for the purpose, and the Trustee shall authenticate and such office or agency shall deliver in exchange for such temporary
Securities an equal aggregate principal amount of definitive Securities of such series, unless the Company advises the Trustee to the
effect that definitive Securities need not be executed and furnished until further notice from the Company. Until so exchanged, the temporary
Securities of such series shall be entitled to the same benefits under this Indenture as definitive Securities of such series authenticated
and delivered hereunder.
Section 2.7 Mutilated, Destroyed, Lost or Stolen
Securities.
In case any temporary or definitive Security shall
become mutilated or be destroyed, lost or stolen, the Company (subject to the next succeeding sentence) shall execute, and upon the Company’s
request the Trustee (subject as aforesaid) shall authenticate and deliver, a new Security of the same series, bearing a number not contemporaneously
outstanding, in exchange and substitution for the mutilated Security, or in lieu of and in substitution for the Security so destroyed,
lost or stolen. In every case the applicant for a substituted Security shall furnish to the Company and the Trustee such security or indemnity
as may be required by them to save each of them harmless, and, in every case of destruction, loss or theft, the applicant shall also furnish
to the Company and the Trustee evidence to their satisfaction of the destruction, loss or theft of the applicant’s Security and of the
ownership thereof. The Trustee may authenticate any such substituted Security and deliver the same upon the written request or authorization
of any officer of the Company. Upon the issuance of any substituted Security, the Company may require the payment of a sum sufficient
to cover any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses
of the Trustee) connected therewith.
In case any Security that has matured or is about
to mature shall become mutilated or be destroyed, lost or stolen, the Company may, instead of issuing a substitute Security, pay or authorize
the payment of the same (without surrender thereof except in the case of a mutilated Security) if the applicant for such payment shall
furnish to the Company and the Trustee such security or indemnity as they may require to save them harmless, and, in case of destruction,
loss or theft, evidence to the satisfaction of the Company and the Trustee of the destruction, loss or theft of such Security and of the
ownership thereof.
Every replacement Security issued pursuant to
the provisions of this Section shall constitute an additional contractual obligation of the Company whether or not the mutilated, destroyed,
lost or stolen Security shall be found at any time, or be enforceable by anyone, and shall be entitled to all the benefits of this Indenture
equally and proportionately with any and all other Securities of the same series duly issued hereunder. All Securities shall be held and
owned upon the express condition that the foregoing provisions are exclusive with respect to the replacement or payment of mutilated,
destroyed, lost or stolen Securities, and shall preclude (to the extent lawful) any and all other rights or remedies, notwithstanding
any law or statute existing or hereafter enacted to the contrary with respect to the replacement or payment of negotiable instruments
or other securities without their surrender.
Section 2.8 Cancellation.
All Securities surrendered for the purpose of
payment, redemption, exchange or registration of transfer shall, if surrendered to the Company or any paying agent, be delivered to the
Trustee for cancellation, or, if surrendered to the Trustee, shall be cancelled by it, and no Securities shall be issued in lieu thereof
except as expressly required or permitted by any of the provisions of this Indenture. On request of the Company at the time of such surrender,
the Trustee shall deliver to the Company canceled Securities held by the Trustee. In the absence of such request the Trustee may dispose
of canceled Securities in accordance with its standard procedures and deliver a certificate of disposition to the Company. If the Company
shall otherwise acquire any of the Securities, however, such acquisition shall not operate as a redemption or satisfaction of the indebtedness
represented by such Securities unless and until the same are delivered to the Trustee for cancellation.
Section 2.9 Benefits of Indenture.
Nothing in this Indenture or in the Securities,
express or implied, shall give or be construed to give to any Person, other than the parties hereto and the holders of the Securities
any legal or equitable right, remedy or claim under or in respect of this Indenture, or under any covenant, condition or provision herein
contained; all such covenants, conditions and provisions being for the sole benefit of the parties hereto and of the holders of the Securities.
Section 2.10 Authenticating Agent.
So long as any of the Securities of any series
remain Outstanding there may be an Authenticating Agent for any or all such series of Securities which the Trustee shall have the right
to appoint. Said Authenticating Agent shall be authorized to act on behalf of the Trustee to authenticate Securities of such series issued
upon exchange, transfer or partial redemption thereof, and Securities so authenticated shall be entitled to the benefits of this Indenture
and shall be valid and obligatory for all purposes as if authenticated by the Trustee hereunder. All references in this Indenture to the
authentication of Securities by the Trustee shall be deemed to include authentication by an Authenticating Agent for such series. Each
Authenticating Agent shall be acceptable to the Company and shall be a corporation that has a combined capital and surplus, as most recently
reported or determined by it, sufficient under the laws of any jurisdiction under which it is organized or in which it is doing business
to conduct a trust business, and that is otherwise authorized under such laws to conduct such business and is subject to supervision or
examination by federal or state authorities. If at any time any Authenticating Agent shall cease to be eligible in accordance with these
provisions, it shall resign immediately.
Any Authenticating Agent may at any time resign
by giving written notice of resignation to the Trustee and to the Company. The Trustee may at any time (and upon request by the Company
shall) terminate the agency of any Authenticating Agent by giving written notice of termination to such Authenticating Agent and to the
Company. Upon resignation, termination or cessation of eligibility of any Authenticating Agent, the Trustee may appoint an eligible successor
Authenticating Agent acceptable to the Company. Any successor Authenticating Agent, upon acceptance of its appointment hereunder, shall
become vested with all the rights, powers and duties of its predecessor hereunder as if originally named as an Authenticating Agent pursuant
hereto.
Section 2.11 Global Securities.
(a) If the Company shall establish pursuant to
Section 2.01 that the Securities of a particular series are to be issued as a Global Security, then the Company shall execute and the
Trustee shall, in accordance with Section 2.04, authenticate and deliver, a Global Security that (i) shall represent, and shall be denominated
in an amount equal to the aggregate principal amount of, all of the Outstanding Securities of such series, (ii) shall be registered in
the name of the Depositary or its nominee, (iii) shall be delivered by the Trustee to the Depositary or pursuant to the Depositary’s instruction
and (iv) shall bear a legend substantially to the following effect: “Except as otherwise provided in Section 2.11 of the Indenture,
this Security may be transferred, in whole but not in part, only to another nominee of the Depositary or to a successor Depositary or
to a nominee of such successor Depositary.”
(b) Notwithstanding the provisions of Section
2.05, the Global Security of a series may be transferred, in whole but not in part and in the manner provided in Section 2.05, only to
another nominee of the Depositary for such series, or to a successor Depositary for such series selected or approved by the Company or
to a nominee of such successor Depositary.
(c) If at any time the Depositary for a
series of the Securities notifies the Company that it is unwilling or unable to continue as Depositary for such series or if at any
time the Depositary for such series shall no longer be registered or in good standing under the Exchange Act, or other applicable
statute or regulation, and a successor Depositary for such series is not appointed by the Company within 90 days after the Company
receives such notice or becomes aware of such condition, as the case may be, or if an Event of Default has occurred and is
continuing and the Company has received a request from the Depositary or from the Trustee, this Section 2.11 shall no longer be
applicable to the Securities of such series and the Company will execute, and subject to Section 2.04, the Trustee will authenticate
and deliver the Securities of such series in definitive registered form without coupons, in authorized denominations, and in an
aggregate principal amount equal to the principal amount of the Global Security of such series in exchange for such Global Security.
In addition, the Company may at any time determine that the Securities of any series shall no longer be represented by a Global
Security and that the provisions of this Section 2.11 shall no longer apply to the Securities of such series. In such event the
Company will execute and, subject to Section 2.04, the Trustee, upon receipt of an Officer’s Certificate evidencing such
determination by the Company, will authenticate and deliver the Securities of such series in definitive registered form without
coupons, in authorized denominations, and in an aggregate principal amount equal to the principal amount of the Global Security of
such series in exchange for such Global Security. Upon the exchange of the Global Security for such Securities in definitive
registered form without coupons, in authorized denominations, the Global Security shall be canceled by the Trustee. Such Securities
in definitive registered form issued in exchange for the Global Security pursuant to this Section 2.11(c) shall be registered in
such names and in such authorized denominations as the Depositary, pursuant to instructions from its direct or indirect participants
or otherwise, shall instruct the Trustee. The Trustee shall deliver such Securities to the Depositary for delivery to the Persons in
whose names such Securities are so registered.
ARTICLE III
REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS
Section 3.1 Redemption.
The Company may redeem the Securities of any series
issued hereunder on and after the dates and in accordance with the terms established for such series pursuant to Section 2.01 hereof.
Section 3.2 Notice of Redemption.
(a) In case the Company shall desire to exercise
such right to redeem all or, as the case may be, a portion of the Securities of any series in accordance with any right the Company reserved
for itself to do so pursuant to Section 2.01 hereof, the Company shall, or shall cause the Trustee to, give notice of such redemption
to holders of the Securities of such series to be redeemed by mailing, first class postage prepaid, a notice of such redemption not less
than 30 days and not more than 90 days before the date fixed for redemption of that series to such holders at their last addresses as
they shall appear upon the Security Register, unless a shorter period is specified in the Securities to be redeemed. Any notice that is
mailed in the manner herein provided shall be conclusively presumed to have been duly given, whether or not the registered holder receives
the notice. In any case, failure duly to give such notice to the holder of any Security of any series designated for redemption in whole
or in part, or any defect in the notice, shall not affect the validity of the proceedings for the redemption of any other Securities of
such series or any other series. In the case of any redemption of Securities prior to the expiration of any restriction on such redemption
provided in the terms of such Securities or elsewhere in this Indenture, the Company shall furnish the Trustee with an Officer’s Certificate
evidencing compliance with any such restriction.
Each such notice of redemption shall specify the
date fixed for redemption and the redemption price at which Securities of that series are to be redeemed, and shall state that payment
of the redemption price of such Securities to be redeemed will be made at the office or agency of the Company, upon presentation and surrender
of such Securities, that interest accrued to the date fixed for redemption will be paid as specified in said notice, that from and after
said date interest will cease to accrue and that the redemption is from a sinking fund, if such is the case. If less than all the Securities
of a series are to be redeemed, the notice to the holders of Securities of that series to be redeemed in part shall specify the particular
Securities to be so redeemed.
In case any Security is to be redeemed in part
only, the notice that relates to such Security shall state the portion of the principal amount thereof to be redeemed, and shall state
that on and after the redemption date, upon surrender of such Security, a new Security or Securities of such series in principal amount
equal to the unredeemed portion thereof will be issued.
(b) If less than all the Securities of a series
are to be redeemed, the Company shall give the Trustee at least 45 days’ notice (unless a shorter notice shall be satisfactory to the
Trustee) in advance of the date fixed for redemption as to the aggregate principal amount of Securities of the series to be redeemed,
and thereupon the Trustee shall select, by lot or in such other manner as it shall deem appropriate and fair in its discretion and that
may provide for the selection of a portion or portions (equal to one thousand U.S. dollars ($1,000) or any integral multiple thereof)
of the principal amount of such Securities of a denomination larger than $1,000, the Securities to be redeemed and shall thereafter promptly
notify the Company in writing of the numbers of the Securities to be redeemed, in whole or in part. The Company may, if and whenever it
shall so elect, by delivery of instructions signed on its behalf by an Officer, instruct the Trustee or any paying agent to call all or
any part of the Securities of a particular series for redemption and to give notice of redemption in the manner set forth in this Section,
such notice to be in the name of the Company or its own name as the Trustee or such paying agent may deem advisable. In any case in which
notice of redemption is to be given by the Trustee or any such paying agent, the Company shall deliver or cause to be delivered to, or
permit to remain with, the Trustee or such paying agent, as the case may be, such Security Register, transfer books or other records,
or suitable copies or extracts therefrom, sufficient to enable the Trustee or such paying agent to give any notice by mail that may be
required under the provisions of this Section.
Section 3.3 Payment Upon Redemption.
(a) If the giving of notice of redemption shall
have been completed as above provided, the Securities or portions of Securities of the series to be redeemed specified in such notice
shall become due and payable on the date and at the place stated in such notice at the applicable redemption price, together with interest
accrued to the date fixed for redemption and interest on such Securities or portions of Securities shall cease to accrue on and after
the date fixed for redemption, unless the Company shall default in the payment of such redemption price and accrued interest with respect
to any such Security or portion thereof. On presentation and surrender of such Securities on or after the date fixed for redemption at
the place of payment specified in the notice, said Securities shall be paid and redeemed at the applicable redemption price for such series,
together with interest accrued thereon to the date fixed for redemption (but if the date fixed for redemption is an interest payment date,
the interest installment payable on such date shall be payable to the registered holder at the close of business on the applicable record
date pursuant to Section 2.03).
(b) Upon presentation of any Security of such
series that is to be redeemed in part only, the Company shall execute and the Trustee shall authenticate and the office or agency where
the Security is presented shall deliver to the holder thereof, at the expense of the Company, a new Security of the same series of authorized
denominations in principal amount equal to the unredeemed portion of the Security so presented.
Section 3.4 Sinking Fund.
The provisions of Sections 3.04, 3.05 and 3.06
shall be applicable to any sinking fund for the retirement of Securities of a series, except as otherwise specified as contemplated by
Section 2.01 for Securities of such series.
The minimum amount of any sinking fund payment
provided for by the terms of Securities of any series is herein referred to as a “mandatory sinking fund payment,” and any payment
in excess of such minimum amount provided for by the terms of Securities of any series is herein referred to as an “optional sinking
fund payment”. If provided for by the terms of Securities of any series, the cash amount of any sinking fund payment may be subject
to reduction as provided in Section 3.05. Each sinking fund payment shall be applied to the redemption of Securities of any series as
provided for by the terms of Securities of such series.
Section 3.5 Satisfaction of Sinking Fund Payments with
Securities.
The Company (i) may deliver Outstanding Securities
of a series and (ii) may apply as a credit Securities of a series that have been redeemed either at the election of the Company pursuant
to the terms of such Securities or through the application of permitted optional sinking fund payments pursuant to the terms of such Securities,
in each case in satisfaction of all or any part of any sinking fund payment with respect to the Securities of such series required to
be made pursuant to the terms of such Securities as provided for by the terms of such series, provided that such Securities have not been
previously so credited. Such Securities shall be received and credited for such purpose by the Trustee at the redemption price specified
in such Securities for redemption through operation of the sinking fund and the amount of such sinking fund payment shall be reduced accordingly.
Section 3.6 Redemption of Securities for Sinking Fund.
Not less than 45 days prior to each sinking fund
payment date for any series of Securities (unless a shorter period shall be satisfactory to the Trustee), the Company will deliver to
the Trustee an Officer’s Certificate specifying the amount of the next ensuing sinking fund payment for that series pursuant to the terms
of the series, the portion thereof, if any, that is to be satisfied by delivering and crediting Securities of that series pursuant to
Section 3.05 and the basis for such credit and will, together with such Officer’s Certificate, deliver to the Trustee any Securities to
be so delivered. Not less than 30 days before each such sinking fund payment date the Trustee shall select the Securities to be redeemed
upon such sinking fund payment date in the manner specified in Section 3.02 and cause notice of the redemption thereof to be given in
the name of and at the expense of the Company in the manner provided in Section 3.02. Such notice having been duly given, the redemption
of such Securities shall be made upon the terms and in the manner stated in Section 3.03.
ARTICLE IV
COVENANTS
Section 4.1 Payment of Principal, Premium and Interest.
The Company will duly and punctually pay or cause
to be paid the principal of (and premium, if any) and interest on the Securities of that series at the time and place and in the manner
provided herein and established with respect to such Securities. Payments of principal on the Securities may be made at the time provided
herein and established with respect to such Securities by U.S. dollar check drawn on and mailed to the address of the Securityholder entitled
thereto as such address shall appear in the Security Register, or U.S. dollar wire transfer to, a U.S. dollar account (such wire transfer
to be made only to a Securityholder of an aggregate principal amount of Securities of the applicable series in excess of U.S. $2,000,000
and only if such Securityholder shall have furnished wire instructions to the Trustee no later than 15 days prior to the relevant payment
date). Payments of interest on the Securities may be made at the time provided herein and established with respect to such Securities
by U.S. dollar check mailed to the address of the Securityholder entitled thereto as such address shall appear in the Security Register,
or U.S. dollar wire transfer to, a U.S. dollar account (such a wire transfer to be made only to a Securityholder of an aggregate principal
amount of Securities of the applicable series in excess of U.S. $2,000,000 and only if such Securityholder shall have furnished wire instructions
in writing to the Security Registrar and the Trustee no later than 15 days prior to the relevant payment date.
Section 4.2 Maintenance of Office or Agency.
So long as any series of the Securities remain
Outstanding, the Company agrees to maintain an office or agency with respect to each such series and at such other location or locations
as may be designated as provided in this Section 4.02, where (i) Securities of that series may be presented for payment, (ii) Securities
of that series may be presented as herein above authorized for registration of transfer and exchange, and (iii) notices and demands to
or upon the Company in respect of the Securities of that series and this Indenture may be given or served, such designation to continue
with respect to such office or agency until the Company shall, by written notice signed by any officer authorized to sign an Officer’s
Certificate and delivered to the Trustee, designate some other office or agency for such purposes or any of them. If at any time the Company
shall fail to maintain any such required office or agency or shall fail to furnish the Trustee with the address thereof, such presentations,
notices and demands may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the Trustee as
its agent to receive all such presentations, notices and demands. The Company initially appoints the Corporate Trust Office of the Trustee
as its paying agent with respect to the Securities.
Section 4.3 Paying Agents.
(a) If the Company shall appoint one or more paying
agents for all or any series of the Securities, other than the Trustee, the Company will cause each such paying agent to execute and deliver
to the Trustee an instrument in which such agent shall agree with the Trustee, subject to the provisions of this Section:
(i) that it will hold all sums held by it as such
agent for the payment of the principal of (and premium, if any) or interest on the Securities of that series (whether such sums have been
paid to it by the Company or by any other obligor of such Securities) in trust for the benefit of the Persons entitled thereto;
(ii) that it will give the Trustee notice of any
failure by the Company (or by any other obligor of such Securities) to make any payment of the principal of (and premium, if any) or interest
on the Securities of that series when the same shall be due and payable;
(iii) that it will, at any time during the continuance
of any failure referred to in the preceding paragraph (a)(2) above, upon the written request of the Trustee, forthwith pay to the Trustee
all sums so held in trust by such paying agent; and
(iv) that it will perform all other duties of paying
agent as set forth in this Indenture.
(b) If the Company shall act as its own
paying agent with respect to any series of the Securities, it will on or before each due date of the principal of (and premium, if
any) or interest on Securities of that series, set aside, segregate and hold in trust for the benefit of the Persons entitled
thereto a sum sufficient to pay such principal (and premium, if any) or interest so becoming due on Securities of that series until
such sums shall be paid to such Persons or otherwise disposed of as herein provided and will promptly notify the Trustee of such
action, or any failure (by it or any other obligor on such Securities) to take such action. Whenever the Company shall have one or
more paying agents for any series of Securities, it will, prior to each due date of the principal of (and premium, if any) or
interest on any Securities of that series, deposit with the paying agent a sum sufficient to pay the principal (and premium, if any)
or interest so becoming due, such sum to be held in trust for the benefit of the Persons entitled to such principal, premium or
interest, and (unless such paying agent is the Trustee) the Company will promptly notify the Trustee of this action or failure so to
act.
(c) Notwithstanding anything in this Section to
the contrary, (i) the agreement to hold sums in trust as provided in this Section is subject to the provisions of Section 11.05, and (ii)
the Company may at any time, for the purpose of obtaining the satisfaction and discharge of this Indenture or for any other purpose, pay,
or direct any paying agent to pay, to the Trustee all sums held in trust by the Company or such paying agent, such sums to be held by
the Trustee upon the same terms and conditions as those upon which such sums were held by the Company or such paying agent; and, upon
such payment by the Company or any paying agent to the Trustee, the Company or such paying agent shall be released from all further liability
with respect to such money.
Section 4.4 Appointment to Fill Vacancy in Office of Trustee.
The Company, whenever necessary to avoid or fill
a vacancy in the office of Trustee, will appoint, in the manner provided in Section 7.10, a Trustee, so that there shall at all times
be a Trustee hereunder.
Section 4.5 Compliance with Consolidation Provisions.
The Company will not, while any of the Securities
remain Outstanding, consolidate with or merge into any other Person, in either case where the Company is not the survivor of such transaction,
or sell or convey all or substantially all of its property to any other Person unless the provisions of Article Ten hereof are complied
with.
ARTICLE V
SECURITYHOLDERS’ LISTS AND REPORTS BY
THE COMPANY AND THE TRUSTEE
Section 5.1 Company to Furnish Trustee Names and Addresses
of Securityholders.
The Company will furnish or cause to be furnished
to the Trustee (a) within 15 days after each regular record date (as defined in Section 2.03) a list, in such form as the Trustee may
reasonably require, of the names and addresses of the holders of each series of Securities as of such regular record date, provided that
the Company shall not be obligated to furnish or cause to furnish such list at any time that the list shall not differ in any respect
from the most recent list furnished to the Trustee by the Company and (b) at such other times as the Trustee may request in writing within
30 days after the receipt by the Company of any such request, a list of similar form and content as of a date not more than 15 days prior
to the time such list is furnished; provided, however, that, in either case, no such list need be furnished for any series for which the
Trustee shall be the Security Registrar.
Section 5.2 Preservation
Of Information; Communications With Securityholders.
(a) The Trustee shall preserve, in as current
a form as is reasonably practicable, all information as to the names and addresses of the holders of Securities contained in the most
recent list furnished to it as provided in Section 5.01 and as to the names and addresses of holders of Securities received by the Trustee
in its capacity as Security Registrar (if acting in such capacity).
(b) The Trustee may destroy any list furnished
to it as provided in Section 5.01 upon receipt of a new list so furnished.
(c) Securityholders may communicate as provided
in Section 312(b) of the Trust Indenture Act with other Securityholders with respect to their rights under this Indenture or under the
Securities, and, in connection with any such communications, the Trustee shall satisfy its obligations under Section 312(b) of the Trust
Indenture Act in accordance with the provisions of Section 312(b) of the Trust Indenture Act.
Section 5.3 Reports by the Company.
The Company covenants and agrees to provide
(which delivery may be via electronic mail) to the Trustee, after the Company files the same with the Securities and Exchange
Commission, copies of the annual reports and of the information, documents and other reports (or copies of such portions of any of
the foregoing as the Securities and Exchange Commission may from time to time by rules and regulations prescribe) that the Company
files with the Securities and Exchange Commission pursuant to Section 13 or Section 15(d) of the Exchange Act; provided, however,
the Company shall not be required to deliver to the Trustee any materials for which the Company has sought and received confidential
treatment by the Securities and Exchange Commission; and provided further, so long as such filings by the Company are available on
the Securities and Exchange Commission’s Electronic Data Gathering, Analysis and Retrieval System (EDGAR), such filings shall be
deemed to have been filed with the Trustee for purposes of this Section 5.03 without any further action required by the Company.
Section 5.4 Reports by the Trustee.
(a) If required by Section 313(a) of the Trust
Indenture Act, the Trustee, within sixty (60) days after each May 1, shall transmit by mail, first class postage prepaid, to the Securityholders,
as their names and addresses appear upon the Security Register, a brief report dated as of such May 1, which complies with Section 313(a)
of the Trust Indenture Act.
(b) The Trustee shall comply with Section 313(b)
and 313(c) of the Trust Indenture Act.
(c) A copy of each such report shall, at the time
of such transmission to Securityholders, be filed by the Trustee with the Company, with each securities exchange upon which any Securities
are listed (if so listed) and also with the Securities and Exchange Commission. The Company agrees to notify the Trustee when any Securities
become listed on any securities exchange.
ARTICLE VI
REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS
ON EVENT OF DEFAULT
Section 6.1 Events of Default.
(a) Whenever used herein with respect to Securities
of a particular series, “Event of Default” means any one or more of the following events that has occurred and is continuing:
(i) the Company defaults in the payment of any installment
of interest upon any of the Securities of that series, as and when the same shall become due and payable, and such default continues for
a period of 90 days; provided, however, that a valid extension of an interest payment period by the Company in accordance with the terms
of any indenture supplemental hereto shall not constitute a default in the payment of interest for this purpose;
(ii) the Company defaults in the payment of the
principal of (or premium, if any, on) any of the Securities of that series as and when the same shall become due and payable whether at
maturity, upon redemption, by declaration or otherwise, or in any payment required by any sinking or analogous fund established with respect
to that series; provided, however, that a valid extension of the maturity of such Securities in accordance with the terms of any indenture
supplemental hereto shall not constitute a default in the payment of principal or premium, if any;
(iii) the Company fails to observe or perform any
other of its covenants or agreements with respect to that series contained in this Indenture or otherwise established with respect to
that series of Securities pursuant to Section 2.01 hereof (other than a covenant or agreement that has been expressly included in this
Indenture solely for the benefit of one or more series of Securities other than such series) for a period of 90 days after the date on
which written notice of such failure, requiring the same to be remedied and stating that such notice is a “Notice of Default”
hereunder, shall have been given to the Company by the Trustee, by registered or certified mail, or to the Company and the Trustee by
the holders of at least 25% in principal amount of the Securities of that series at the time Outstanding;
(iv) the Company pursuant to or within the meaning
of any Bankruptcy Law (i) commences a voluntary case, (ii) consents to the entry of an order for relief against it in an involuntary case,
(iii) consents to the appointment of a Custodian of it or for all or substantially all of its property or (iv) makes a general assignment
for the benefit of its creditors; or
(v) a court of competent jurisdiction enters an
order under any Bankruptcy Law that (i) is for relief against the Company in an involuntary case, (ii) appoints a Custodian of the Company
for all or substantially all of its property or (iii) orders the liquidation of the Company, and the order or decree remains unstayed
and in effect for 90 days.
(b) In each and every such case (other than an
Event of Default specified in clause (4) or clause (5) above), unless the principal of all the Securities of that series shall have already
become due and payable, either the Trustee or the holders of not less than 25% in aggregate principal amount of the Securities of that
series then Outstanding hereunder, by notice in writing to the Company (and to the Trustee if given by such Securityholders), may declare
the principal of (and premium, if any, on) and accrued and unpaid interest on all the Securities of that series to be due and payable
immediately, and upon any such declaration the same shall become and shall be immediately due and payable. If an Event of Default specified
in clause (4) or clause (5) above occurs, the principal of and accrued and unpaid interest on all the Securities of that series shall
automatically be immediately due and payable without any declaration or other act on the part of the Trustee or the holders of the Securities.
(c) At any time after the principal of (and premium,
if any, on) and accrued and unpaid interest on the Securities of that series shall have been so declared due and payable, and before any
judgment or decree for the payment of the moneys due shall have been obtained or entered as hereinafter provided, the holders of a majority
in aggregate principal amount of the Securities of that series then Outstanding hereunder, by written notice to the Company and the Trustee,
may rescind and annul such declaration and its consequences if: (i) the Company has paid or deposited with the Trustee a sum sufficient
to pay all matured installments of interest upon all the Securities of that series and the principal of (and premium, if any, on) any
and all Securities of that series that shall have become due otherwise than by acceleration (with interest upon such principal and premium,
if any, and, to the extent that such payment is enforceable under applicable law, upon overdue installments of interest, at the rate per
annum expressed in the Securities of that series to the date of such payment or deposit) and the amount payable to the Trustee under Section
7.06, and (ii) any and all Events of Default under the Indenture with respect to such series, other than the nonpayment of principal on
(and premium, if any, on) and accrued and unpaid interest on Securities of that series that shall not have become due by their terms,
shall have been remedied or waived as provided in Section 6.06.
No such rescission and annulment shall extend
to or shall affect any subsequent default or impair any right consequent thereon.
(d) In case the Trustee shall have proceeded to
enforce any right with respect to Securities of that series under this Indenture and such proceedings shall have been discontinued or
abandoned because of such rescission or annulment or for any other reason or shall have been determined adversely to the Trustee, then
and in every such case, subject to any determination in such proceedings, the Company and the Trustee shall be restored respectively to
their former positions and rights hereunder, and all rights, remedies and powers of the Company and the Trustee shall continue as though
no such proceedings had been taken.
Section 6.2 Collection of Indebtedness and Suits for Enforcement
by Trustee.
(a) The Company covenants that (i) in case it
shall default in the payment of any installment of interest on any of the Securities of a series, or in any payment required by any sinking
or analogous fund established with respect to that series as and when the same shall have become due and payable, and such default shall
have continued for a period of 90 days, or (ii) in case it shall default in the payment of the principal of (or premium, if any, on) any
of the Securities of a series when the same shall have become due and payable, whether upon maturity of the Securities of a series or
upon redemption or upon declaration or otherwise then, upon demand of the Trustee, the Company will pay to the Trustee, for the benefit
of the holders of the Securities of that series, the whole amount that then shall have been become due and payable on all such Securities
for principal (and premium, if any) or interest, or both, as the case may be, with interest upon the overdue principal (and premium, if
any) and (to the extent that payment of such interest is enforceable under applicable law) upon overdue installments of interest at the
rate per annum expressed in the Securities of that series; and, in addition thereto, such further amount as shall be sufficient to cover
the costs and expenses of collection, and the amount payable to the Trustee under Section 7.06.
(b) If the Company shall fail to pay such amounts
forthwith upon such demand, the Trustee, in its own name and as trustee of an express trust, shall be entitled and empowered to institute
any action or proceedings at law or in equity for the collection of the sums so due and unpaid, and may prosecute any such action or proceeding
to judgment or final decree, and may enforce any such judgment or final decree against the Company or other obligor upon the Securities
of that series and collect the moneys adjudged or decreed to be payable in the manner provided by law or equity out of the property of
the Company or other obligor upon the Securities of that series, wherever situated.
(c) In case of any receivership, insolvency,
liquidation, bankruptcy, reorganization, readjustment, arrangement, composition or judicial proceedings affecting the Company, or
its creditors or property, the Trustee shall have power to intervene in such proceedings and take any action therein that may be
permitted by the court and shall (except as may be otherwise provided by law) be entitled to file such proofs of claim and other
papers and documents as may be necessary or advisable in order to have the claims of the Trustee and of the holders of Securities of
such series allowed for the entire amount due and payable by the Company under the Indenture at the date of institution of such
proceedings and for any additional amount that may become due and payable by the Company after such date, and to collect and receive
any moneys or other property payable or deliverable on any such claim, and to distribute the same after the deduction of the amount
payable to the Trustee under Section 7.06; and any receiver, assignee or trustee in bankruptcy or reorganization is hereby
authorized by each of the holders of Securities of such series to make such payments to the Trustee, and, in the event that the
Trustee shall consent to the making of such payments directly to such Securityholders, to pay to the Trustee any amount due it under
Section 7.06.
(d) All rights of action and of asserting claims
under this Indenture, or under any of the terms established with respect to Securities of that series, may be enforced by the Trustee
without the possession of any of such Securities, or the production thereof at any trial or other proceeding relative thereto, and any
such suit or proceeding instituted by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of
judgment shall, after provision for payment to the Trustee of any amounts due under Section 7.06, be for the ratable benefit of the holders
of the Securities of such series.
In case of an Event of Default hereunder, the
Trustee may in its discretion proceed to protect and enforce the rights vested in it by this Indenture by such appropriate judicial proceedings
as the Trustee shall deem most effectual to protect and enforce any of such rights, either at law or in equity or in bankruptcy or otherwise,
whether for the specific enforcement of any covenant or agreement contained in the Indenture or in aid of the exercise of any power granted
in this Indenture, or to enforce any other legal or equitable right vested in the Trustee by this Indenture or by law.
Nothing contained herein shall be deemed to authorize
the Trustee to authorize or consent to or accept or adopt on behalf of any Securityholder any plan of reorganization, arrangement, adjustment
or composition affecting the Securities of that series or the rights of any holder thereof or to authorize the Trustee to vote in respect
of the claim of any Securityholder in any such proceeding.
Section 6.3 Application of Moneys Collected.
Any moneys collected by the Trustee pursuant to
this Article with respect to a particular series of Securities shall be applied in the following order, at the date or dates fixed by
the Trustee and, in case of the distribution of such moneys on account of principal (or premium, if any) or interest, upon presentation
of the Securities of that series, and notation thereon of the payment, if only partially paid, and upon surrender thereof if fully paid:
FIRST: To the payment of reasonable costs and
expenses of collection and of all amounts payable to the Trustee under Section 7.06;
SECOND: To the payment of the amounts then due
and unpaid upon Securities of such series for principal (and premium, if any) and interest, in respect of which or for the benefit of
which such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on
such Securities for principal (and premium, if any) and interest, respectively; and
THIRD: To the payment of the remainder, if any,
to the Company or any other Person lawfully entitled thereto.
Section 6.4 Limitation on Suits.
No holder of any Security of any series shall
have any right by virtue or by availing of any provision of this Indenture to institute any suit, action or proceeding in equity or at
law upon or under or with respect to this Indenture or for the appointment of a receiver or trustee, or for any other remedy hereunder,
unless (i) such holder previously shall have given to the Trustee written notice of an Event of Default and of the continuance thereof
with respect to the Securities of such series specifying such Event of Default, as hereinbefore provided; (ii) the holders of not less
than 25% in aggregate principal amount of the Securities of such series then Outstanding shall have made written request upon the Trustee
to institute such action, suit or proceeding in its own name as Trustee hereunder; (iii) such holder or holders shall have offered to
the Trustee such reasonable indemnity as it may require against the costs, expenses and liabilities to be incurred therein or thereby;
(iv) the Trustee for 90 days after its receipt of such notice, request and offer of indemnity, shall have failed to institute any such
action, suit or proceeding and (v) during such 90 day period, the holders of a majority in principal amount of the Securities of that
series do not give the Trustee a direction inconsistent with the request.
Notwithstanding anything contained herein to
the contrary or any other provisions of this Indenture, the right of any holder of any Security to receive payment of the principal
of (and premium, if any) and interest on such Security, as therein provided, on or after the respective due dates expressed in such
Security (or in the case of redemption, on the redemption date), or to institute suit for the enforcement of any such payment on or
after such respective dates or redemption date, shall not be impaired or affected without the consent of such holder and by
accepting a Security hereunder it is expressly understood, intended and covenanted by the taker and holder of every Security of such
series with every other such taker and holder and the Trustee, that no one or more holders of Securities of such series shall have
any right in any manner whatsoever by virtue or by availing of any provision of this Indenture to affect, disturb or prejudice the
rights of the holders of any other of such Securities, or to obtain or seek to obtain priority over or preference to any other such
holder, or to enforce any right under this Indenture, except in the manner herein provided and for the equal, ratable and common
benefit of all holders of Securities of such series. For the protection and enforcement of the provisions of this Section, each and
every Securityholder and the Trustee shall be entitled to such relief as can be given either at law or in equity.
Section 6.5 Rights and Remedies Cumulative; Delay or Omission
Not Waiver.
(a) Except as otherwise provided in Section 2.07,
all powers and remedies given by this Article to the Trustee or to the Securityholders shall, to the extent permitted by law, be deemed
cumulative and not exclusive of any other powers and remedies available to the Trustee or the holders of the Securities, by judicial proceedings
or otherwise, to enforce the performance or observance of the covenants and agreements contained in this Indenture or otherwise established
with respect to such Securities.
(b) No delay or omission of the Trustee or of
any holder of any of the Securities to exercise any right or power accruing upon any Event of Default occurring and continuing as aforesaid
shall impair any such right or power, or shall be construed to be a waiver of any such default or an acquiescence therein; and, subject
to the provisions of Section 6.04, every power and remedy given by this Article or by law to the Trustee or the Securityholders may be
exercised from time to time, and as often as shall be deemed expedient, by the Trustee or by the Securityholders.
Section 6.6 Control by Securityholders.
The holders of a majority in aggregate principal
amount of the Securities of any series at the time Outstanding, determined in accordance with Section 8.04, shall have the right to direct
the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred
on the Trustee with respect to such series; provided, however, that such direction shall not be in conflict with any rule of law or with
this Indenture. Subject to the provisions of Section 7.01, the Trustee shall have the right to decline to follow any such direction if
the Trustee in good faith shall, by a Responsible Officer or officers of the Trustee, determine that the proceeding so directed, subject
to the Trustee’s duties under the Trust Indenture Act, would involve the Trustee in personal liability or might be unduly prejudicial
to the Securityholders not involved in the proceeding. The holders of a majority in aggregate principal amount of the Securities of any
series at the time Outstanding affected thereby, determined in accordance with Section 8.04, may on behalf of the holders of all of the
Securities of such series waive any past default in the performance of any of the covenants contained herein or established pursuant to
Section 2.01 with respect to such series and its consequences, except a default in the payment of the principal of, or premium, if any,
or interest on, any of the Securities of that series as and when the same shall become due by the terms of such Securities otherwise than
by acceleration (unless such default has been cured and a sum sufficient to pay all matured installments of interest and principal and
any premium has been deposited with the Trustee (in accordance with Section 6.01(c)). Upon any such waiver, the default covered thereby
shall be deemed to be cured for all purposes of this Indenture and the Company, the Trustee and the holders of the Securities of such
series shall be restored to their former positions and rights hereunder, respectively; but no such waiver shall extend to any subsequent
or other default or impair any right consequent thereon.
Section 6.7 Undertaking to Pay Costs.
All parties to this Indenture agree, and each
holder of any Securities by such holder’s acceptance thereof shall be deemed to have agreed, that any court may in its discretion require,
in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken or
omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and that such
court may in its discretion assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having
due regard to the merits and good faith of the claims or defenses made by such party litigant; but the provisions of this Section shall
not apply to any suit instituted by the Trustee, to any suit instituted by any Securityholder, or group of Securityholders, holding more
than 10% in aggregate principal amount of the Outstanding Securities of any series, or to any suit instituted by any Securityholder for
the enforcement of the payment of the principal of (or premium, if any) or interest on any Security of such series, on or after the respective
due dates expressed in such Security or established pursuant to this Indenture.
ARTICLE VII
CONCERNING THE TRUSTEE
Section 7.1 Certain Duties and Responsibilities
of Trustee.
(a) The Trustee, prior to the occurrence of an
Event of Default with respect to the Securities of a series and after the curing of all Events of Default with respect to the Securities
of that series that may have occurred, shall undertake to perform with respect to the Securities of such series such duties and only such
duties as are specifically set forth in this Indenture, and no implied covenants shall be read into this Indenture against the Trustee.
In case an Event of Default with respect to the Securities of a series has occurred (that has not been cured or waived), the Trustee shall
exercise with respect to Securities of that series such of the rights and powers vested in it by this Indenture, and use the same degree
of care and skill in their exercise, as a prudent man would exercise or use under the circumstances in the conduct of his own affairs.
(b) No provision of this Indenture shall be construed
to relieve the Trustee from liability for its own negligent action, its own negligent failure to act, or its own willful misconduct, except
that:
(1) prior to the occurrence of an Event of Default
with respect to the Securities of a series and after the curing or waiving of all such Events of Default with respect to that series that
may have occurred: (A) the duties and obligations of the Trustee shall with respect to the Securities of such series be determined solely
by the express provisions of this Indenture, and the Trustee shall not be liable with respect to the Securities of such series except
for the performance of such duties and obligations as are specifically set forth in this Indenture, and no implied covenants or obligations
shall be read into this Indenture against the Trustee; and (B) in the absence of bad faith on the part of the Trustee, the Trustee may
with respect to the Securities of such series conclusively rely, as to the truth of the statements and the correctness of the opinions
expressed therein, upon any certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture; but
in the case of any such certificates or opinions that by any provision hereof are specifically required to be furnished to the Trustee,
the Trustee shall be under a duty to examine the same to determine whether or not they conform to the requirements of this Indenture;
(2) the Trustee shall not be liable for any error
of judgment made in good faith by a Responsible Officer or Responsible Officers of the Trustee, unless it shall be proved that the Trustee
was negligent in ascertaining the pertinent facts;
(3) the Trustee shall not be liable with respect
to any action taken or omitted to be taken by it in good faith in accordance with the direction of the holders of not less than a majority
in principal amount of the Securities of any series at the time Outstanding relating to the time, method and place of conducting any proceeding
for any remedy available to the Trustee, or exercising any trust or power conferred upon the Trustee under this Indenture with respect
to the Securities of that series; and
(4) none of the provisions contained in this Indenture
shall require the Trustee to expend or risk its own funds or otherwise incur personal financial liability in the performance of any of
its duties or in the exercise of any of its rights or powers if there is reasonable ground for believing that the repayment of such funds
or liability is not reasonably assured to it under the terms of this Indenture or adequate indemnity against such risk is not reasonably
assured to it.
Section 7.2 Certain Rights of Trustee.
Except as otherwise provided in Section 7.01:
(a) The Trustee may rely and shall be protected
in acting or refraining from acting upon any resolution, certificate, statement, instrument, opinion, report, notice, request, consent,
order, approval, bond, security or other paper or document believed by it to be genuine and to have been signed or presented by the proper
party or parties;
(b) Any request, direction, order or demand of
the Company mentioned herein shall be sufficiently evidenced by a Board Resolution or an instrument signed in the name of the Company
by any authorized officer of the Company (unless other evidence in respect thereof is specifically prescribed herein);
(c) The Trustee may consult with counsel and the
written advice of such counsel or, if requested, any Opinion of Counsel shall be full and complete authorization and protection in respect
of any action taken or suffered or omitted hereunder in good faith and in reliance thereon;
(d) The Trustee shall be under no obligation to
exercise any of the rights or powers vested in it by this Indenture at the request, order or direction of any of the Securityholders pursuant
to the provisions of this Indenture, unless such Securityholders shall have offered to the Trustee reasonable security or indemnity against
the costs, expenses and liabilities that may be incurred therein or thereby; nothing contained herein shall, however, relieve the Trustee
of the obligation, upon the occurrence of an Event of Default with respect to a series of the Securities (that has not been cured or waived),
to exercise with respect to Securities of that series such of the rights and powers vested in it by this Indenture, and to use the same
degree of care and skill in their exercise, as a prudent man would exercise or use under the circumstances in the conduct of his own affairs;
(e) The Trustee shall not be liable for any action
taken or omitted to be taken by it in good faith and believed by it to be authorized or within the discretion or rights or powers conferred
upon it by this Indenture;
(f) The Trustee shall not be bound to make any
investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report, notice, request,
consent, order, approval, bond, security, or other papers or documents, unless requested in writing so to do by the holders of not less
than a majority in principal amount of the Outstanding Securities of the particular series affected thereby (determined as provided in
Section 8.04); provided, however, that if the payment within a reasonable time to the Trustee of the costs, expenses or liabilities likely
to be incurred by it in the making of such investigation is, in the opinion of the Trustee, not reasonably assured to the Trustee by the
security afforded to it by the terms of this Indenture, the Trustee may require reasonable indemnity against such costs, expenses or liabilities
as a condition to so proceeding. The reasonable expense of every such examination shall be paid by the Company or, if paid by the Trustee,
shall be repaid by the Company upon demand; and
(g) The Trustee may execute any of the trusts
or powers hereunder or perform any duties hereunder either directly or by or through agents or attorneys and the Trustee shall not be
responsible for any misconduct or negligence on the part of any agent or attorney appointed with due care by it hereunder.
In addition, the Trustee shall not be deemed to
have knowledge of any Default or Event of Default except (1) any Event of Default occurring pursuant to Sections 6.01(a)(1) and 6.01(a)(2)
or (2) any Default or Event of Default of which the Trustee shall have received written notification in the manner set forth in this Indenture
or a Responsible Officer of the Trustee shall have obtained actual knowledge. Delivery of reports, information and documents to the Trustee
under Section 5.03 is for informational purposes only and the information and the Trustee’s receipt of the foregoing shall not constitute
constructive notice of any information contained therein, or determinable from information contained therein including the Company’s compliance
with any of their covenants thereunder (as to which the Trustee is entitled to rely exclusively on an Officer’s Certificate).
Section 7.3 Trustee Not Responsible
for Recitals or Issuance or Securities.
(a) The recitals contained herein and in the Securities
shall be taken as the statements of the Company, and the Trustee assumes no responsibility for the correctness of the same.
(b) The Trustee makes no representations as to
the validity or sufficiency of this Indenture or of the Securities.
(c) The Trustee shall not be accountable for the
use or application by the Company of any of the Securities or of the proceeds of such Securities, or for the use or application of any
moneys paid over by the Trustee in accordance with any provision of this Indenture or established pursuant to Section 2.01, or for the
use or application of any moneys received by any paying agent other than the Trustee.
Section 7.4 May Hold Securities.
The Trustee or any paying agent or Security Registrar,
in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if it were not
Trustee, paying agent or Security Registrar.
Section 7.5 Moneys Held in Trust.
Subject to the provisions of Section 11.05, all
moneys received by the Trustee shall, until used or applied as herein provided, be held in trust for the purposes for which they were
received, but need not be segregated from other funds except to the extent required by law. The Trustee shall be under no liability for
interest on any moneys received by it hereunder except such as it may agree with the Company to pay thereon.
Section 7.6 Compensation and Reimbursement.
(a) The Company covenants and agrees to pay to
the Trustee, and the Trustee shall be entitled to, such reasonable compensation (which shall not be limited by any provision of law in
regard to the compensation of a trustee of an express trust) as the Company and the Trustee may from time to time agree in writing, for
all services rendered by it in the execution of the trusts hereby created and in the exercise and performance of any of the powers and
duties hereunder of the Trustee, and, except as otherwise expressly provided herein, the Company will pay or reimburse the Trustee upon
its request for all reasonable expenses, disbursements and advances incurred or made by the Trustee in accordance with any of the provisions
of this Indenture (including the reasonable compensation and the expenses and disbursements of its counsel and of all Persons not regularly
in its employ), except any such expense, disbursement or advance as may arise from its negligence or bad faith and except as the Company
and Trustee may from time to time agree in writing. The Company also covenants to indemnify the Trustee (and its officers, agents, directors
and employees) for, and to hold it harmless against, any loss, liability or expense incurred without negligence or bad faith on the part
of the Trustee and arising out of or in connection with the acceptance or administration of this trust, including the reasonable costs
and expenses of defending itself against any claim of liability in the premises.
(b) The obligations of the Company under this
Section to compensate and indemnify the Trustee and to pay or reimburse the Trustee for reasonable expenses, disbursements and advances
shall constitute additional indebtedness hereunder. Such additional indebtedness shall be secured by a lien prior to that of the Securities
upon all property and funds held or collected by the Trustee as such, except funds held in trust for the benefit of the holders of particular
Securities.
Section 7.7 Reliance on Officer’s
Certificate.
Except as otherwise provided in Section 7.01,
whenever in the administration of the provisions of this Indenture the Trustee shall deem it reasonably necessary or desirable that a
matter be proved or established prior to taking or suffering or omitting to take any action hereunder, such matter (unless other evidence
in respect thereof be herein specifically prescribed) may, in the absence of negligence or bad faith on the part of the Trustee, be deemed
to be conclusively proved and established by an Officer’s Certificate delivered to the Trustee and such certificate, in the absence of
negligence or bad faith on the part of the Trustee, shall be full warrant to the Trustee for any action taken, suffered or omitted to
be taken by it under the provisions of this Indenture upon the faith thereof.
Section 7.8 Disqualification; Conflicting Interests.
If the Trustee has or shall acquire any “conflicting
interest” within the meaning of Section 310(b) of the Trust Indenture Act, the Trustee and the Company shall in all respects comply
with the provisions of Section 310(b) of the Trust Indenture Act.
Section 7.9 Corporate Trustee Required;
Eligibility.
There shall at all times be a Trustee with respect
to the Securities issued hereunder which shall at all times be a corporation organized and doing business under the laws of the United
States of America or any state or territory thereof or of the District of Columbia, or a corporation or other Person permitted to act
as trustee by the Securities and Exchange Commission, authorized under such laws to exercise corporate trust powers, having a combined
capital and surplus of at least fifty million U.S. dollars ($50,000,000), and subject to supervision or examination by federal, state,
territorial, or District of Columbia authority.
If such corporation or other Person publishes
reports of condition at least annually, pursuant to law or to the requirements of the aforesaid supervising or examining authority, then
for the purposes of this Section, the combined capital and surplus of such corporation or other Person shall be deemed to be its combined
capital and surplus as set forth in its most recent report of condition so published. The Company may not, nor may any Person directly
or indirectly controlling, controlled by, or under common control with the Company, serve as Trustee. In case at any time the Trustee
shall cease to be eligible in accordance with the provisions of this Section, the Trustee shall resign immediately in the manner and with
the effect specified in Section 7.10.
Section 7.10 Resignation and Removal; Appointment of Successor.
(a) The Trustee or any successor
hereafter appointed may at any time resign with respect to the Securities of one or more series by giving written notice thereof to the
Company and by transmitting notice of resignation by mail, first class postage prepaid, to the Securityholders of such series, as their
names and addresses appear upon the Security Register. Upon receiving such notice of resignation, the Company shall promptly appoint
a successor trustee with respect to Securities of such series by written instrument, in duplicate, executed by order of the Board of
Directors, one copy of which instrument shall be delivered to the resigning Trustee and one copy to the successor trustee. If no successor
trustee shall have been so appointed and have accepted appointment within 30 days after the mailing of such notice of resignation, the
resigning Trustee may petition any court of competent jurisdiction for the appointment of a successor trustee with respect to Securities
of such series, or any Securityholder of that series who has been a bona fide holder of a Security or Securities for at least six months
may on behalf of himself and all others similarly situated, petition any such court for the appointment of a successor trustee. Such
court may thereupon after such notice, if any, as it may deem proper and prescribe, appoint a successor trustee.
(b) In case at any time any one of the following
shall occur:
(1) the Trustee shall fail to comply with the provisions
of Section 7.08 after written request therefor by the Company or by any Securityholder who has been a bona fide holder of a Security or
Securities for at least six months; or
(2) the Trustee shall cease to be eligible in accordance
with the provisions of Section 7.09 and shall fail to resign after written request therefor by the Company or by any such Securityholder;
or
(3) the Trustee shall become incapable of acting,
or shall be adjudged a bankrupt or insolvent, or commence a voluntary bankruptcy proceeding, or a receiver of the Trustee or of its property
shall be appointed or consented to, or any public officer shall take charge or control of the Trustee or of its property or affairs for
the purpose of rehabilitation, conservation or liquidation; then, in any such case, the Company may remove the Trustee with respect to
all Securities and appoint a successor trustee by written instrument, in duplicate, executed by order of the Board of Directors, one copy
of which instrument shall be delivered to the Trustee so removed and one copy to the successor trustee, or any Securityholder who has
been a bona fide holder of a Security or Securities for at least six months may, on behalf of that holder and all others similarly situated,
petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor trustee. Such court may
thereupon after such notice, if any, as it may deem proper and prescribe, remove the Trustee and appoint a successor trustee.
(c) The holders of a majority in aggregate principal
amount of the Securities of any series at the time Outstanding may at any time remove the Trustee with respect to such series by so notifying
the Trustee and the Company and may appoint a successor Trustee for such series with the consent of the Company.
(d) Any resignation or removal of the Trustee
and appointment of a successor trustee with respect to the Securities of a series pursuant to any of the provisions of this Section shall
become effective upon acceptance of appointment by the successor trustee as provided in Section 7.11.
(e) Any successor trustee appointed pursuant to
this Section may be appointed with respect to the Securities of one or more series or all of such series, and at any time there shall
be only one Trustee with respect to the Securities of any particular series.
Section 7.11 Acceptance of Appointment By Successor.
(a) In case of the appointment hereunder of a
successor trustee with respect to all Securities, every such successor trustee so appointed shall execute, acknowledge and deliver to
the Company and to the retiring Trustee an instrument accepting such appointment, and thereupon the resignation or removal of the retiring
Trustee shall become effective and such successor trustee, without any further act, deed or conveyance, shall become vested with all the
rights, powers, trusts and duties of the retiring Trustee; but, on the request of the Company or the successor trustee, such retiring
Trustee shall, upon payment of its charges, execute and deliver an instrument transferring to such successor trustee all the rights, powers,
and trusts of the retiring Trustee and shall duly assign, transfer and deliver to such successor trustee all property and money held by
such retiring Trustee hereunder.
(b) In case of the appointment hereunder of
a successor trustee with respect to the Securities of one or more (but not all) series, the Company, the retiring Trustee and each
successor trustee with respect to the Securities of one or more series shall execute and deliver an indenture supplemental hereto
wherein each successor trustee shall accept such appointment and which (i) shall contain such provisions as shall be necessary or
desirable to transfer and confirm to, and to vest in, each successor trustee all the rights, powers, trusts and duties of the
retiring Trustee with respect to the Securities of that or those series to which the appointment of such successor trustee relates,
(ii) shall contain such provisions as shall be deemed necessary or desirable to confirm that all the rights, powers, trusts and
duties of the retiring Trustee with respect to the Securities of that or those series as to which the retiring Trustee is not
retiring shall continue to be vested in the retiring Trustee, and (iii) shall add to or change any of the provisions of this
Indenture as shall be necessary to provide for or facilitate the administration of the trusts hereunder by more than one Trustee, it
being understood that nothing herein or in such supplemental indenture shall constitute such Trustees co-trustees of the same trust,
that each such Trustee shall be trustee of a trust or trusts hereunder separate and apart from any trust or trusts hereunder
administered by any other such Trustee and that no Trustee shall be responsible for any act or failure to act on the part of any
other Trustee hereunder; and upon the execution and delivery of such supplemental indenture the resignation or removal of the
retiring Trustee shall become effective to the extent provided therein, such retiring Trustee shall with respect to the Securities
of that or those series to which the appointment of such successor trustee relates have no further responsibility for the exercise
of rights and powers or for the performance of the duties and obligations vested in the Trustee under this Indenture, and each such
successor trustee, without any further act, deed or conveyance, shall become vested with all the rights, powers, trusts and duties
of the retiring Trustee with respect to the Securities of that or those series to which the appointment of such successor trustee
relates; but, on request of the Company or any successor trustee, such retiring Trustee shall duly assign, transfer and deliver to
such successor trustee, to the extent contemplated by such supplemental indenture, the property and money held by such retiring
Trustee hereunder with respect to the Securities of that or those series to which the appointment of such successor trustee
relates.
(c) Upon request of any such successor trustee,
the Company shall execute any and all instruments for more fully and certainly vesting in and confirming to such successor trustee all
such rights, powers and trusts referred to in paragraph (a) or (b) of this Section, as the case may be.
(d) No successor trustee shall accept its appointment
unless at the time of such acceptance such successor trustee shall be qualified and eligible under this Article.
(e) Upon acceptance of appointment by a successor
trustee as provided in this Section, the Company shall transmit notice of the succession of such trustee hereunder by mail, first class
postage prepaid, to the Securityholders, as their names and addresses appear upon the Security Register. If the Company fails to transmit
such notice within ten days after acceptance of appointment by the successor trustee, the successor trustee shall cause such notice to
be transmitted at the expense of the Company.
Section 7.12 Merger, Conversion, Consolidation or Succession
to Business.
Any corporation into which the Trustee may be
merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to
which the Trustee shall be a party, or any corporation succeeding to the corporate trust business of the Trustee, including the administration
of the trust created by this Indenture, shall be the successor of the Trustee hereunder, provided that such corporation shall be qualified
under the provisions of Section 7.08 and eligible under the provisions of Section 7.09, without the execution or filing of any paper or
any further act on the part of any of the parties hereto, anything herein to the contrary notwithstanding. In case any Securities shall
have been authenticated, but not delivered, by the Trustee then in office, any successor by merger, conversion or consolidation to such
authenticating Trustee may adopt such authentication and deliver the Securities so authenticated with the same effect as if such successor
Trustee had itself authenticated such Securities.
Section 7.13 Preferential Collection of Claims Against
the Company.
The Trustee shall comply with Section 311(a) of
the Trust Indenture Act, excluding any creditor relationship described in Section 311(b) of the Trust Indenture Act. A Trustee who has
resigned or been removed shall be subject to Section 311(a) of the Trust Indenture Act to the extent included therein.
Section 7.14 Notice of Default
If any Default or any Event of Default occurs
and is continuing and if such Default or Event of Default is known to a Responsible Officer of the Trustee, the Trustee shall mail to
each Securityholder in the manner and to the extent provided in Section 313(c) of the Trust Indenture Act notice of the Default or Event
of Default within the earlier of 90 days after it occurs and 30 days after it is known to a Responsible Officer of the Trustee or written
notice of it is received by the Trustee, unless such Default or Event of Default has been cured; provided, however, that, except in the
case of a default in the payment of the principal of (or premium, if any) or interest on any Security, the Trustee shall be protected
in withholding such notice if and so long as the board of directors, the executive committee or a trust committee of directors and/or
Responsible Officers of the Trustee in good faith determine that the withholding of such notice is in the interest of the Securityholders.
ARTICLE VIII
CONCERNING THE SECURITYHOLDERS
Section 8.1 Evidence of Action by Securityholders.
Whenever in this Indenture it is provided that
the holders of a majority or specified percentage in aggregate principal amount of the Securities of a particular series may take any
action (including the making of any demand or request, the giving of any notice, consent or waiver or the taking of any other action),
the fact that at the time of taking any such action the holders of such majority or specified percentage of that series have joined therein
may be evidenced by any instrument or any number of instruments of similar tenor executed by such holders of Securities of that series
in person or by agent or proxy appointed in writing.
If the Company shall solicit from the Securityholders
of any series any request, demand, authorization, direction, notice, consent, waiver or other action, the Company may, at its option,
as evidenced by an Officer’s Certificate, fix in advance a record date for such series for the determination of Securityholders entitled
to give such request, demand, authorization, direction, notice, consent, waiver or other action, but the Company shall have no obligation
to do so. If such a record date is fixed, such request, demand, authorization, direction, notice, consent, waiver or other action may
be given before or after the record date, but only the Securityholders of record at the close of business on the record date shall be
deemed to be Securityholders for the purposes of determining whether Securityholders of the requisite proportion of Outstanding Securities
of that series have authorized or agreed or consented to such request, demand, authorization, direction, notice, consent, waiver or other
action, and for that purpose the Outstanding Securities of that series shall be computed as of the record date; provided, however, that
no such authorization, agreement or consent by such Securityholders on the record date shall be deemed effective unless it shall become
effective pursuant to the provisions of this Indenture not later than six months after the record date.
Section 8.2 Proof of Execution by Securityholders.
Subject to the provisions of Section 7.01, proof
of the execution of any instrument by a Securityholder (such proof will not require notarization) or his agent or proxy and proof of the
holding by any Person of any of the Securities shall be sufficient if made in the following manner:
(a) The fact and date of the execution by any
such Person of any instrument may be proved in any reasonable manner acceptable to the Trustee.
(b) The ownership of Securities shall be proved
by the Security Register of such Securities or by a certificate of the Security Registrar thereof.
The Trustee may require such additional proof
of any matter referred to in this Section as it shall deem necessary.
Section 8.3 Who May be Deemed Owners.
Prior to the due presentment for registration
of transfer of any Security, the Company, the Trustee, any paying agent and any Security Registrar may deem and treat the Person in whose
name such Security shall be registered upon the books of the Company as the absolute owner of such Security (whether or not such Security
shall be overdue and notwithstanding any notice of ownership or writing thereon made by anyone other than the Security Registrar) for
the purpose of receiving payment of or on account of the principal of, premium, if any, and (subject to Section 2.03) interest on such
Security and for all other purposes; and neither the Company nor the Trustee nor any paying agent nor any Security Registrar shall be
affected by any notice to the contrary.
Section 8.4 Certain Securities Owned by Company Disregarded.
In determining whether the holders of the
requisite aggregate principal amount of Securities of a particular series have concurred in any direction, consent or waiver under
this Indenture, the Securities of that series that are owned by the Company or any other obligor on the Securities of that series or
by any Person directly or indirectly controlling or controlled by or under common control with the Company or any other obligor on
the Securities of that series shall be disregarded and deemed not to be Outstanding for the purpose of any such determination,
except that for the purpose of determining whether the Trustee shall be protected in relying on any such direction, consent or
waiver, only Securities of such series that the Trustee actually knows are so owned shall be so disregarded. The Securities so owned
that have been pledged in good faith may be regarded as Outstanding for the purposes of this Section, if the pledgee shall establish
to the satisfaction of the Trustee the pledgee’s right so to act with respect to such Securities and that the pledgee is not a
Person directly or indirectly controlling or controlled by or under direct or indirect common control with the Company or any such
other obligor. In case of a dispute as to such right, any decision by the Trustee taken upon the advice of counsel shall be full
protection to the Trustee.
Section 8.5 Actions Binding on Future
Securityholders.
At any time prior to (but not after) the evidencing
to the Trustee, as provided in Section 8.01, of the taking of any action by the holders of the majority or percentage in aggregate principal
amount of the Securities of a particular series specified in this Indenture in connection with such action, any holder of a Security of
that series that is shown by the evidence to be included in the Securities the holders of which have consented to such action may, by
filing written notice with the Trustee, and upon proof of holding as provided in Section 8.02, revoke such action so far as concerns such
Security. Except as aforesaid any such action taken by the holder of any Security shall be conclusive and binding upon such holder and
upon all future holders and owners of such Security, and of any Security issued in exchange therefor, on registration of transfer thereof
or in place thereof, irrespective of whether or not any notation in regard thereto is made upon such Security. Any action taken by the
holders of the majority or percentage in aggregate principal amount of the Securities of a particular series specified in this Indenture
in connection with such action shall be conclusively binding upon the Company, the Trustee and the holders of all the Securities of that
series.
ARTICLE IX
SUPPLEMENTAL INDENTURES
Section 9.1 Supplemental Indentures Without
the Consent of Securityholders.
In addition to any supplemental indenture otherwise
authorized by this Indenture, the Company and the Trustee may from time to time and at any time enter into an indenture or indentures
supplemental hereto (which shall conform to the provisions of the Trust Indenture Act as then in effect), without the consent of the Securityholders,
for one or more of the following purposes:
(a) to cure any ambiguity, defect, or inconsistency
herein or in the Securities of any series;
(b) to comply with Article Ten;
(c) to provide for uncertificated Securities in
addition to or in place of certificated Securities;
(d) to add to the covenants, restrictions, conditions
or provisions relating to the Company for the benefit of the holders of all or any series of Securities (and if such covenants, restrictions,
conditions or provisions are to be for the benefit of less than all series of Securities, stating that such covenants, restrictions, conditions
or provisions are expressly being included solely for the benefit of such series), to make the occurrence, or the occurrence and the continuance,
of a default in any such additional covenants, restrictions, conditions or provisions an Event of Default, or to surrender any right or
power herein conferred upon the Company;
(e) to add to, delete from, or revise the conditions,
limitations, and restrictions on the authorized amount, terms, or purposes of issue, authentication, and delivery of Securities, as herein
set forth;
(f) to make any change that does not adversely
affect the rights of any Securityholder in any material respect;
(g) to provide for the issuance of and establish
the form and terms and conditions of the Securities of any series as provided in Section 2.01, to establish the form of any certifications
required to be furnished pursuant to the terms of this Indenture or any series of Securities, or to add to the rights of the holders of
any series of Securities;
(h) to evidence and provide for the acceptance
of appointment hereunder by a successor trustee; or
(i) to comply with any requirements of the Securities
and Exchange Commission or any successor in connection with the qualification of this Indenture under the Trust Indenture Act.
The Trustee is hereby authorized to join
with the Company in the execution of any such supplemental indenture, and to make any further appropriate agreements and
stipulations that may be therein contained, but the Trustee shall not be obligated to enter into any such supplemental indenture
that affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise.
Any supplemental indenture authorized by the provisions
of this Section may be executed by the Company and the Trustee without the consent of the holders of any of the Securities at the time
Outstanding, notwithstanding any of the provisions of Section 9.02.
Section 9.2 Supplemental Indentures With Consent of Securityholders.
With the consent (evidenced as provided in Section
8.01) of the holders of not less than a majority in aggregate principal amount of the Securities of each series affected by such supplemental
indenture or indentures at the time Outstanding, the Company, when authorized by a Board Resolution, and the Trustee may from time to
time and at any time enter into an indenture or indentures supplemental hereto (which shall conform to the provisions of the Trust Indenture
Act as then in effect) for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of this
Indenture or of any supplemental indenture or of modifying in any manner not covered by Section 9.01 the rights of the holders of the
Securities of such series under this Indenture; provided, however, that no such supplemental indenture shall, without the consent of the
holders of each Security then Outstanding and affected thereby, (a) extend the fixed maturity of any Securities of any series, or reduce
the principal amount thereof, or reduce the rate or extend the time of payment of interest thereon, or reduce any premium payable upon
the redemption thereof or (b) reduce the aforesaid percentage of Securities, the holders of which are required to consent to any such
supplemental indenture.
It shall not be necessary for the consent of the
Securityholders of any series affected thereby under this Section to approve the particular form of any proposed supplemental indenture,
but it shall be sufficient if such consent shall approve the substance thereof.
Section 9.3 Effect of Supplemental Indentures.
Upon the execution of any supplemental indenture
pursuant to the provisions of this Article or of Section 10.01, this Indenture shall, with respect to such series, be and be deemed to
be modified and amended in accordance therewith and the respective rights, limitations of rights, obligations, duties and immunities under
this Indenture of the Trustee, the Company and the holders of Securities of the series affected thereby shall thereafter be determined,
exercised and enforced hereunder subject in all respects to such modifications and amendments, and all the terms and conditions of any
such supplemental indenture shall be and be deemed to be part of the terms and conditions of this Indenture for any and all purposes.
Section 9.4 Securities Affected by Supplemental Indentures.
Securities of any series affected by a supplemental
indenture, authenticated and delivered after the execution of such supplemental indenture pursuant to the provisions of this Article or
of Section 10.01, may bear a notation in form approved by the Company, provided such form meets the requirements of any securities exchange
upon which such series may be listed, as to any matter provided for in such supplemental indenture. If the Company shall so determine,
new Securities of that series so modified as to conform, in the opinion of the Board of Directors, to any modification of this Indenture
contained in any such supplemental indenture may be prepared by the Company, authenticated by the Trustee and delivered in exchange for
the Securities of that series then Outstanding.
Section 9.5 Execution of Supplemental Indentures.
Upon the request of the Company, accompanied by
its Board Resolutions authorizing the execution of any such supplemental indenture, and upon the filing with the Trustee of evidence of
the consent of Securityholders required to consent thereto as aforesaid, the Trustee shall join with the Company in the execution of such
supplemental indenture unless such supplemental indenture affects the Trustee’s own rights, duties or immunities under this Indenture
or otherwise, in which case the Trustee may in its discretion but shall not be obligated to enter into such supplemental indenture. The
Trustee, subject to the provisions of Section 7.01, may receive an Officer’s Certificate or, if requested, an Opinion of Counsel as conclusive
evidence that any supplemental indenture executed pursuant to this Article is authorized or permitted by, and conforms to, the terms of
this Article and that it is proper for the Trustee under the provisions of this Article to join in the execution thereof; provided, however,
that such Officer’s Certificate or Opinion of Counsel need not be provided in connection with the execution of a supplemental indenture
that establishes the terms of a series of Securities pursuant to Section 2.01 hereof.
Promptly after the execution by the Company and
the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Trustee shall transmit by mail, first class
postage prepaid, a notice, setting forth in general terms the substance of such supplemental indenture, to the Securityholders of all
series affected thereby as their names and addresses appear upon the Security Register. Any failure of the Trustee to mail such notice,
or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture.
ARTICLE X
SUCCESSOR ENTITY
Section 10.1 Company May Consolidate, Etc.
Except as provided pursuant to Section 2.01 pursuant
to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental to this Indenture,
nothing contained in this Indenture shall prevent any consolidation or merger of the Company with or into any other Person (whether or
not affiliated with the Company) or successive consolidations or mergers in which the Company or its successor or successors shall be
a party or parties, or shall prevent any sale, conveyance, transfer or other disposition of the property of the Company or its successor
or successors as an entirety, or substantially as an entirety, to any other corporation (whether or not affiliated with the Company or
its successor or successors) authorized to acquire and operate the same; provided, however, (a) the Company hereby covenants and agrees
that, upon any such consolidation or merger (in each case, if the Company is not the survivor of such transaction), sale, conveyance,
transfer or other disposition, the due and punctual payment of the principal of (premium, if any) and interest on all of the Securities
of all series in accordance with the terms of each series, according to their tenor, and the due and punctual performance and observance
of all the covenants and conditions of this Indenture with respect to each series or established with respect to such series pursuant
to Section 2.01 to be kept or performed by the Company shall be expressly assumed, by supplemental indenture (which shall conform to the
provisions of the Trust Indenture Act, as then in effect) reasonably satisfactory in form to the Trustee executed and delivered to the
Trustee by the entity formed by such consolidation, or into which the Company shall have been merged, or by the entity which shall have
acquired such property and (b) in the event that the Securities of any series then Outstanding are convertible into or exchangeable for
shares of common stock or other securities of the Company, such entity shall, by such supplemental indenture, make provision so that the
Securityholders of Securities of that series shall thereafter be entitled to receive upon conversion or exchange of such Securities the
number of securities or property to which a holder of the number of shares of common stock or other securities of the Company deliverable
upon conversion or exchange of those Securities would have been entitled had such conversion or exchange occurred immediately prior to
such consolidation, merger, sale, conveyance, transfer or other disposition.
Section 10.2 Successor Entity Substituted.
(a) In case of any such consolidation, merger,
sale, conveyance, transfer or other disposition and upon the assumption by the successor entity by supplemental indenture, executed and
delivered to the Trustee and satisfactory in form to the Trustee, of the obligations set forth under Section 10.01 on all of the Securities
of all series Outstanding, such successor entity shall succeed to and be substituted for the Company with the same effect as if it had
been named as the Company herein, and thereupon the predecessor corporation shall be relieved of all obligations and covenants under this
Indenture and the Securities.
(b) In case of any such consolidation, merger,
sale, conveyance, transfer or other disposition, such changes in phraseology and form (but not in substance) may be made in the Securities
thereafter to be issued as may be appropriate.
(c) Nothing contained in this Article shall require
any action by the Company in the case of a consolidation or merger of any Person into the Company where the Company is the survivor of
such transaction, or the acquisition by the Company, by purchase or otherwise, of all or any part of the property of any other Person
(whether or not affiliated with the Company).
Section 10.3 Evidence of Consolidation, Etc. to Trustee.
The Trustee, subject to the provisions of Section
7.01, may receive an Officer’s Certificate and, if requested, an Opinion of Counsel as conclusive evidence that any such consolidation,
merger, sale, conveyance, transfer or other disposition, and any such assumption, comply with the provisions of this Article.
ARTICLE XI
SATISFACTION AND DISCHARGE
Section 11.1 Satisfaction and Discharge of
Indenture.
If at any time: (a) the Company shall have delivered
to the Trustee for cancellation all Securities of a series theretofore authenticated and not delivered to the Trustee for cancellation
(other than any Securities that shall have been destroyed, lost or stolen and that shall have been replaced or paid as provided in Section
2.07 and Securities for whose payment money or Governmental Obligations have theretofore been deposited in trust or segregated and held
in trust by the Company and thereupon repaid to the Company or discharged from such trust, as provided in Section 11.05); or (b) all such
Securities of a particular series not theretofore delivered to the Trustee for cancellation shall have become due and payable, or are
by their terms to become due and payable within one year or are to be called for redemption within one year under arrangements satisfactory
to the Trustee for the giving of notice of redemption, and the Company shall deposit or cause to be deposited with the Trustee as trust
funds the entire amount in moneys or Governmental Obligations or a combination thereof, sufficient in the opinion of a nationally recognized
firm of independent public accountants expressed in a written certification thereof delivered to the Trustee, to pay at maturity or upon
redemption all Securities of that series not theretofore delivered to the Trustee for cancellation, including principal (and premium,
if any) and interest due or to become due to such date of maturity or date fixed for redemption, as the case may be, and if the Company
shall also pay or cause to be paid all other sums payable hereunder with respect to such series by the Company then this Indenture shall
thereupon cease to be of further effect with respect to such series except for the provisions of Sections 2.03, 2.05, 2.07, 4.01, 4.02,
4.03 and 7.10, that shall survive until the date of maturity or redemption date, as the case may be, and Sections 7.06 and 11.05, that
shall survive to such date and thereafter, and the Trustee, on demand of the Company and at the cost and expense of the Company shall
execute proper instruments acknowledging satisfaction of and discharging this Indenture with respect to such series.
Section 11.2 Discharge of Obligations.
If at any time all such Securities of a particular
series not heretofore delivered to the Trustee for cancellation or that have not become due and payable as described in Section 11.01
shall have been paid by the Company by depositing irrevocably with the Trustee as trust funds moneys or an amount of Governmental Obligations
sufficient to pay at maturity or upon redemption all such Securities of that series not theretofore delivered to the Trustee for cancellation,
including principal (and premium, if any) and interest due or to become due to such date of maturity or date fixed for redemption, as
the case may be, and if the Company shall also pay or cause to be paid all other sums payable hereunder by the Company with respect to
such series, then after the date such moneys or Governmental Obligations, as the case may be, are deposited with the Trustee the obligations
of the Company under this Indenture with respect to such series shall cease to be of further effect except for the provisions of Sections
2.03, 2.05, 2.07, 4,01, 4.02, 4,03, 7.06, 7.10 and 11.05 hereof that shall survive until such Securities shall mature and be paid.
Thereafter, Sections 7.06 and 11.05 shall survive.
Section 11.3 Deposited Moneys to be Held in Trust.
All moneys or Governmental Obligations deposited
with the Trustee pursuant to Sections 11.01 or 11.02 shall be held in trust and shall be available for payment as due, either directly
or through any paying agent (including the Company acting as its own paying agent), to the holders of the particular series of Securities
for the payment or redemption of which such moneys or Governmental Obligations have been deposited with the Trustee.
Section 11.4 Payment of Moneys Held by Paying Agents.
In connection with the satisfaction and discharge
of this Indenture all moneys or Governmental Obligations then held by any paying agent under the provisions of this Indenture shall, upon
demand of the Company, be paid to the Trustee and thereupon such paying agent shall be released from all further liability with respect
to such moneys or Governmental Obligations.
Section 11.5 Repayment to Company.
Any moneys or Governmental Obligations deposited
with any paying agent or the Trustee, or then held by the Company, in trust for payment of principal of or premium, if any, or interest
on the Securities of a particular series that are not applied but remain unclaimed by the holders of such Securities for at least two
years after the date upon which the principal of (and premium, if any) or interest on such Securities shall have respectively become due
and payable, or such other shorter period set forth in applicable escheat or abandoned or unclaimed property law, shall be repaid to the
Company on May 31 of each year or upon the Company’s request or (if then held by the Company) shall be discharged from such trust; and
thereupon the paying agent and the Trustee shall be released from all further liability with respect to such moneys or Governmental Obligations,
and the holder of any of the Securities entitled to receive such payment shall thereafter, as a general creditor, look only to the Company
for the payment thereof.
ARTICLE XII
IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS
AND DIRECTORS
Section 12.1 No Recourse.
No recourse under or upon any obligation, covenant
or agreement of this Indenture, or of any Security, or for any claim based thereon or otherwise in respect thereof, shall be had against
any incorporator, stockholder, officer or director, past, present or future as such, of the Company or of any predecessor or successor
corporation, either directly or through the Company or any such predecessor or successor corporation, whether by virtue of any constitution,
statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that this Indenture
and the obligations issued hereunder are solely corporate obligations, and that no such personal liability whatever shall attach to, or
is or shall be incurred by, the incorporators, stockholders, officers or directors as such, of the Company or of any predecessor or successor
corporation, or any of them, because of the creation of the indebtedness hereby authorized, or under or by reason of the obligations,
covenants or agreements contained in this Indenture or in any of the Securities or implied therefrom; and that any and all such personal
liability of every name and nature, either at common law or in equity or by constitution or statute, of, and any and all such rights and
claims against, every such incorporator, stockholder, officer or director as such, because of the creation of the indebtedness hereby
authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture or in any of the Securities
or implied therefrom, are hereby expressly waived and released as a condition of, and as a consideration for, the execution of this Indenture
and the issuance of such Securities.
ARTICLE XIII
MISCELLANEOUS PROVISIONS
Section 13.1 Effect on Successors and Assigns.
All the covenants, stipulations, promises and
agreements in this Indenture made by or on behalf of the Company shall bind its successors and assigns, whether so expressed or not.
Section 13.2 Actions by Successor .
Any act or proceeding by any provision of this
Indenture authorized or required to be done or performed by any board, committee or officer of the Company shall and may be done and performed
with like force and effect by the corresponding board, committee or officer of any corporation that shall at the time be the lawful successor
of the Company.
Section 13.3 Surrender of Company Powers.
The Company by instrument in writing executed
by authority of its Board of Directors and delivered to the Trustee may surrender any of the powers reserved to the Company, and thereupon
such power so surrendered shall terminate both as to the Company and as to any successor corporation.
Section 13.4 Notices.
Except as otherwise expressly provided
herein, any notice, request or demand that by any provision of this Indenture is required or permitted to be given, made or served
by the Trustee or by the holders of Securities or by any other Person pursuant to this Indenture to or on the Company may be given
or served by being deposited in first class mail, postage prepaid, addressed (until another address is filed in writing by the
Company with the Trustee), as follows:
Any notice, election, request or demand by the
Company or any Securityholder or by any other Person pursuant to this Indenture to or upon the Trustee shall be deemed to have been sufficiently
given or made, for all purposes, if given or made in writing at the Corporate Trust Office of the Trustee.
Section 13.5 Governing Law.
This Indenture and each Security shall be deemed
to be a contract made under the internal laws of the State of New York, and for all purposes shall be construed in accordance with the
laws of said State, except to the extent that the Trust Indenture Act is applicable.
Section 13.6 Treatment of Securities as Debt.
It is intended that the Securities will be treated
as indebtedness and not as equity for federal income tax purposes. The provisions of this Indenture shall be interpreted to further this
intention.
Section 13.7 Certificates and Opinions as to Conditions
Precedent.
(a) Upon any application or demand by the Company
to the Trustee to take any action under any of the provisions of this Indenture, the Company shall furnish to the Trustee an Officer’s
Certificate stating that all conditions precedent provided for in this Indenture (other than the certificate to be delivered pursuant
to Section 13.12) relating to the proposed action have been complied with and, if requested, an Opinion of Counsel stating that in the
opinion of such counsel all such conditions precedent have been complied with, except that in the case of any such application or demand
as to which the furnishing of such documents is specifically required by any provision of this Indenture relating to such particular application
or demand, no additional certificate or opinion need be furnished.
(b) Each certificate or opinion provided for in
this Indenture and delivered to the Trustee with respect to compliance with a condition or covenant in this Indenture shall include (i)
a statement that the Person making such certificate or opinion has read such covenant or condition; (ii) a brief statement as to the nature
and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based;
(iii) a statement that, in the opinion of such Person, he has made such examination or investigation as is reasonably necessary to enable
him to express an informed opinion as to whether or not such covenant or condition has been complied with; and (iv) a statement as to
whether or not, in the opinion of such Person, such condition or covenant has been complied with.
Section 13.8 Payments on Business Days.
Except as provided pursuant to Section 2.01 pursuant
to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental to this Indenture,
in any case where the date of maturity of interest or principal of any Security or the date of redemption of any Security shall not be
a Business Day, then payment of interest or principal (and premium, if any) may be made on the next succeeding Business Day with the same
force and effect as if made on the nominal date of maturity or redemption, and no interest shall accrue for the period after such nominal
date.
Section 13.9 Conflict with Trust Indenture Act.
If and to the extent that any provision of this
Indenture limits, qualifies or conflicts with the duties imposed by Sections 310 to 317, inclusive, of the Trust Indenture Act, such imposed
duties shall control.
Section 13.10 Counterparts.
This Indenture may be executed in any number of
counterparts, each of which shall be an original, but such counterparts shall together constitute but one and the same instrument.
Section 13.11 Separability.
In case any one or more of the provisions
contained in this Indenture or in the Securities of any series shall for any reason be held to be invalid, illegal or unenforceable
in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Indenture or of such
Securities, but this Indenture and such Securities shall be construed as if such invalid or illegal or unenforceable provision had
never been contained herein or therein.
Section 13.12 Compliance Certificates.
The Company shall deliver to the Trustee, within
120 days after the end of each fiscal year during which any Securities of any series were outstanding, an officer’s certificate stating
whether or not the signers know of any Default or Event of Default that occurred during such fiscal year. Such certificate shall contain
a certification from the principal executive officer, principal financial officer or principal accounting officer of the Company that
a review has been conducted of the activities of the Company and the Company’s performance under this Indenture and that the Company has
complied with all conditions and covenants under this Indenture. For purposes of this Section 13.12, such compliance shall be determined
without regard to any period of grace or requirement of notice provided under this Indenture. If the officer of the Company signing such
certificate has knowledge of such a Default or Event of Default, the certificate shall describe any such Default or Event of Default and
its status.
IN WITNESS WHEREOF, the parties hereto have caused
this Indenture to be duly executed all as of the day and year first above written.
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UNICYCIVE THERAPEUTICS, INC. |
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By: |
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Name: |
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Title: |
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[TRUSTEE], as Trustee |
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By: |
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Title: |
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-30-
Exhibit 4.4
UNICYCIVE THERAPEUTICS, INC.,
ISSUER
AND
[TRUSTEE],
TRUSTEE
INDENTURE
DATED AS OF , 20__
SUBORDINATED DEBT SECURITIES
TABLE OF CONTENTS
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Page |
ARTICLE 1 DEFINITIONS |
1 |
Section 1.01 Definitions of Terms |
1 |
ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES |
4 |
Section 2.01 Designation and Terms of Securities |
4 |
Section 2.02 Form of Securities and Trustee’s Certificate |
5 |
Section 2.03 Denominations: Provisions for Payment |
5 |
Section 2.04 Execution and Authentications |
6 |
Section 2.05 Registration of Transfer and Exchange |
7 |
Section 2.06 Temporary Securities |
8 |
Section 2.07 Mutilated, Destroyed, Lost or Stolen Securities |
8 |
Section 2.08 Cancellation |
8 |
Section 2.09 Benefits of Indenture |
8 |
Section 2.10 Authenticating Agent |
9 |
Section 2.11 Global Securities |
9 |
ARTICLE 3 REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS |
10 |
Section 3.01 Redemption |
10 |
Section 3.02 Notice of Redemption |
10 |
Section 3.03 Payment Upon Redemption |
11 |
Section 3.04 Sinking Fund |
11 |
Section 3.05 Satisfaction of Sinking Fund Payments with Securities |
11 |
Section 3.06 Redemption of Securities for Sinking Fund |
11 |
ARTICLE 4 COVENANTS |
11 |
Section 4.01 Payment of Principal, Premium and Interest |
11 |
Section 4.02 Maintenance of Office or Agency |
12 |
Section 4.03 Paying Agents |
12 |
Section 4.04 Appointment to Fill Vacancy in Office of Trustee |
13 |
Section 4.05 Compliance with Consolidation Provisions |
13 |
ARTICLE 5 SECURITYHOLDERS’ LISTS AND REPORTS BY THE COMPANY AND THE TRUSTEE |
13 |
Section 5.01 Company to Furnish Trustee Names and Addresses of Securityholders |
13 |
Section 5.02 Preservation Of Information; Communications With Securityholders |
13 |
Section 5.03 Reports by the Company |
13 |
Section 5.04 Reports by the Trustee |
14 |
ARTICLE 6 REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT |
14 |
Section 6.01 Events of Default |
14 |
Section 6.02 Collection of Indebtedness and Suits for Enforcement by Trustee |
15 |
Section 6.03 Application of Moneys Collected |
16 |
Section 6.04 Limitation on Suits |
16 |
Section 6.05 Rights and Remedies Cumulative; Delay or Omission Not Waiver |
17 |
Section 6.06 Control by Securityholders |
17 |
Section 6.07 Undertaking to Pay Costs |
17 |
ARTICLE 7 CONCERNING THE TRUSTEE |
18 |
Section 7.01 Certain Duties and Responsibilities of Trustee |
18 |
Section 7.02 Certain Rights of Trustee |
18 |
Section 7.03 Trustee Not Responsible for Recitals or Issuance or Securities |
19 |
Section 7.04 May Hold Securities |
19 |
Section 7.05 Moneys Held in Trust |
20 |
Section 7.06 Compensation and Reimbursement |
20 |
Section 7.07 Reliance on Officer’s Certificate |
20 |
Section 7.08 Disqualification; Conflicting Interests |
20 |
Section 7.09 Corporate Trustee Required; Eligibility |
20 |
Section 7.10 Resignation and Removal; Appointment of Successor |
21 |
Section 7.11 Acceptance of Appointment By Successor |
21 |
Section 7.12 Merger, Conversion, Consolidation or Succession to Business |
22 |
Section 7.13 Preferential Collection of Claims Against the Company |
22 |
Section 7.14 Notice of Default |
22 |
ARTICLE 8 CONCERNING THE SECURITYHOLDERS |
23 |
Section 8.01 Evidence of Action by Securityholders |
23 |
Section 8.02 Proof of Execution by Securityholders |
23 |
Section 8.03 Who May be Deemed Owners |
23 |
Section 8.04 Certain Securities Owned by Company Disregarded |
24 |
Section 8.05 Actions Binding on Future Securityholders |
24 |
ARTICLE 9 SUPPLEMENTAL INDENTURES |
24 |
Section 9.01 Supplemental Indentures Without the Consent of Securityholders |
24 |
Section 9.02 Supplemental Indentures With Consent of Securityholders |
25 |
Section 9.03 Effect of Supplemental Indentures |
25 |
Section 9.04 Securities Affected by Supplemental Indentures |
25 |
Section 9.05 Execution of Supplemental Indentures |
25 |
ARTICLE 10 SUCCESSOR ENTITY |
26 |
Section 10.01 Company May Consolidate, Etc |
26 |
Section 10.02 Successor Entity Substituted |
26 |
Section 10.03 Evidence of Consolidation, Etc |
27 |
ARTICLE 11 SATISFACTION AND DISCHARGE |
27 |
Section 11.01 Satisfaction and Discharge of Indenture |
27 |
Section 11.02 Discharge of Obligations |
27 |
Section 11.03 Deposited Moneys to be Held in Trust |
27 |
Section 11.04 Payment of Moneys Held by Paying Agents |
27 |
Section 11.05 Repayment to Company |
28 |
ARTICLE 12 IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS AND DIRECTORS |
28 |
Section 12.01 No Recourse |
28 |
ARTICLE 13 MISCELLANEOUS PROVISIONS |
28 |
Section 13.01 Effect on Successors and Assigns |
28 |
Section 13.02 Actions by Successor |
28 |
Section 13.03 Surrender of Company Powers |
28 |
Section 13.04 Notices |
29 |
Section 13.05 Governing Law |
29 |
Section 13.06 Treatment of Securities as Debt |
29 |
Section 13.07 Certificates and Opinions as to Conditions Precedent |
29 |
Section 13.08 Payments on Business Days |
29 |
Section 13.09 Conflict with Trust Indenture Act |
30 |
Section 13.10 Counterparts |
30 |
Section 13.11 Separability |
30 |
Section 13.12 Compliance Certificates |
30 |
ARTICLE 14 SUBORDINATION OF SECURITIES |
30 |
Section 14.01 Subordination Terms |
30 |
| (1) | This Table of Contents does not constitute part of the Indenture
and shall not have any bearing on the interpretation of any of its terms or provisions. |
INDENTURE
INDENTURE , dated as of
[ ● ], among Unicycive Therapeutics, Inc. , a Delaware corporation (the “Company”), and [ TRUSTEE ],
as trustee (the “Trustee”):
WHEREAS, for its lawful corporate purposes, the
Company has duly authorized the execution and delivery of this Indenture to provide for the issuance of subordinated debt securities (hereinafter
referred to as the “Securities”), in an unlimited aggregate principal amount to be issued from time to time in one or more series
as in this Indenture provided, as registered Securities without coupons, to be authenticated by the certificate of the Trustee;
WHEREAS, to provide the terms and conditions upon
which the Securities are to be authenticated, issued and delivered, the Company has duly authorized the execution of this Indenture; and
WHEREAS, all things necessary to make this Indenture
a valid agreement of the Company, in accordance with its terms, have been done.
NOW, THEREFORE, in consideration of the premises
and the purchase of the Securities by the holders thereof, it is mutually covenanted and agreed as follows for the equal and ratable benefit
of the holders of Securities:
ARTICLE 1
DEFINITIONS
Section 1.01 Definitions of Terms .
The terms defined in this Section (except as in
this Indenture or any indenture supplemental hereto otherwise expressly provided or unless the context otherwise requires) for all purposes
of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section and shall include
the plural as well as the singular. All other terms used in this Indenture that are defined in the Trust Indenture Act of 1939, as amended,
or that are by reference in such Act defined in the Securities Act of 1933, as amended (except as herein or any indenture supplemental
hereto otherwise expressly provided or unless the context otherwise requires), shall have the meanings assigned to such terms in said
Trust Indenture Act and in said Securities Act as in force at the date of the execution of this instrument.
“Authenticating Agent” means an authenticating
agent with respect to all or any of the series of Securities appointed by the Trustee pursuant to Section 2.10.
“Bankruptcy Law” means Title 11, U.S.
Code, or any similar federal or state law for the relief of debtors.
“Board of Directors” means the Board
of Directors of the Company or any duly authorized committee of such Board.
“Board Resolution” means a copy of a
resolution certified by the Secretary or an Assistant Secretary of the Company to have been duly adopted by the Board of Directors and
to be in full force and effect on the date of such certification.
“Business Day” means, with respect to
any series of Securities, any day other than a day on which federal or state banking institutions in the Borough of Manhattan, the City
of New York, or in the city of the Corporate Trust Office of the Trustee, are authorized or obligated by law, executive order or regulation
to close.
“Certificate” means a certificate signed
by any Officer. The Certificate need not comply with the provisions of Section 13.07.
“Company” means Unicycive Therapeutics,
Inc., a corporation duly organized and existing under the laws of the State of Delaware, and, subject to the provisions of Article Ten,
shall also include its successors and assigns.
“Corporate Trust Office” means the office
of the Trustee at which, at any particular time, its corporate trust business shall be principally administered, which office at the date
hereof is located at .
“Custodian” means any receiver, trustee,
assignee, liquidator or similar official under any Bankruptcy Law.
“Default” means any event, act or condition
that with notice or lapse of time, or both, would constitute an Event of Default.
“Defaulted Interest” has the meaning
set forth in Section 2.03.
“Depositary” means, with respect to
Securities of any series for which the Company shall determine that such Securities will be issued as a Global Security, The Depository
Trust Company, another clearing agency, or any successor registered as a clearing agency under the Exchange Act, or other applicable statute
or regulation, which, in each case, shall be designated by the Company pursuant to either Section 2.01 or 2.11.
“Event of Default” means, with respect
to Securities of a particular series, any event specified in Section 6.01, continued for the period of time, if any, therein designated.
“Exchange Act” means the Securities
and Exchange Act of 1934, as amended.
“Global Security” means, with respect
to any series of Securities, a Security executed by the Company and delivered by the Trustee to the Depositary or pursuant to the Depositary’s
instruction, all in accordance with the Indenture, which shall be registered in the name of the Depositary or its nominee.
“Governmental Obligations” means securities
that are (a) direct obligations of the United States of America for the payment of which its full faith and credit is pledged or (b) obligations
of a Person controlled or supervised by and acting as an agency or instrumentality of the United States of America, the payment of which
is unconditionally guaranteed as a full faith and credit obligation by the United States of America that, in either case, are not callable
or redeemable at the option of the issuer thereof at any time prior to the stated maturity of the Securities, and shall also include a
depositary receipt issued by a bank or trust company as custodian with respect to any such Governmental Obligation or a specific payment
of principal of or interest on any such Governmental Obligation held by such custodian for the account of the holder of such depositary
receipt; provided, however, that (except as required by law) such custodian is not authorized to make any deduction from the amount payable
to the holder of such depositary receipt from any amount received by the custodian in respect of the Governmental Obligation or the specific
payment of principal of or interest on the Governmental Obligation evidenced by such depositary receipt.
“herein”, “hereof” and “hereunder”,
and other words of similar import, refer to this Indenture as a whole and not to any particular Article, Section or other subdivision.
“Indenture” means this instrument as
originally executed or as it may from time to time be supplemented or amended by one or more indentures supplemental hereto entered into
in accordance with the terms hereof.
“Interest Payment Date”, when used with
respect to any installment of interest on a Security of a particular series, means the date specified in such Security or in a Board Resolution
or in an indenture supplemental hereto with respect to such series as the fixed date on which an installment of interest with respect
to Securities of that series is due and payable.
“Officer” means, with respect to the
Company, the chairman of the Board of Directors, a chief executive officer, a president, a chief financial officer, a chief operating
officer, any executive vice president, any senior vice president, any vice president, the treasurer or any assistant treasurer, the controller
or any assistant controller or the secretary or any assistant secretary.
“Officer’s Certificate” means a certificate
signed by any Officer. Each such certificate shall include the statements provided for in Section 13.07, if and to the extent required
by the provisions thereof.
“Opinion of Counsel” means an opinion
in writing subject to customary exceptions of legal counsel, who may be an employee of or counsel for the Company, that is delivered to
the Trustee in accordance with the terms hereof. Each such opinion shall include the statements provided for in Section 13.07, if and
to the extent required by the provisions thereof.
“Outstanding”,
when used with reference to Securities of any series, means, subject to the provisions of Section 8.04, as of any particular time,
all Securities of that series theretofore authenticated and delivered by the Trustee under this Indenture, except (a) Securities
theretofore canceled by the Trustee or any paying agent, or delivered to the Trustee or any paying agent for cancellation or that
have previously been canceled; (b) Securities or portions thereof for the payment or redemption of which moneys or Governmental
Obligations in the necessary amount shall have been deposited in trust with the Trustee or with any paying agent (other than the
Company) or shall have been set aside and segregated in trust by the Company (if the Company shall act as its own paying agent);
provided, however, that if such Securities or portions of such Securities are to be redeemed prior to the maturity thereof, notice
of such redemption shall have been given as provided in Article Three, or provision satisfactory to the Trustee shall have been made
for giving such notice; and (c) Securities in lieu of or in substitution for which other Securities shall have been authenticated
and delivered pursuant to the terms of Section 2.07.
“Person” means any individual, corporation,
partnership, joint venture, joint-stock company, limited liability company, association, trust, unincorporated organization, any other
entity or organization, including a government or political subdivision or an agency or instrumentality thereof.
“Predecessor Security” of any particular
Security means every previous Security evidencing all or a portion of the same debt as that evidenced by such particular Security; and,
for the purposes of this definition, any Security authenticated and delivered under Section 2.07 in lieu of a lost, destroyed or stolen
Security shall be deemed to evidence the same debt as the lost, destroyed or stolen Security.
“Responsible Officer” when used with
respect to the Trustee means the chairman of its board of directors, the chief executive officer, the president, any vice president, the
secretary, the treasurer, any trust officer, any corporate trust officer or any other officer or assistant officer of the Trustee customarily
performing functions similar to those performed by the Persons who at the time shall be such officers, respectively, or to whom any corporate
trust matter is referred because of his or her knowledge of and familiarity with the particular subject.
“Securities” means the debt Securities
authenticated and delivered under this Indenture.
“Securityholder”, “holder of Securities”,
“registered holder”, or other similar term, means the Person or Persons in whose name or names a particular Security shall be
registered on the books of the Company kept for that purpose in accordance with the terms of this Indenture.
“Security Register” and “Security
Registrar” shall have the meanings as set forth in Section 2.05.
“Subsidiary” means, with respect to
any Person, (i) any corporation at least a majority of whose outstanding Voting Stock shall at the time be owned, directly or indirectly,
by such Person or by one or more of its Subsidiaries or by such Person and one or more of its Subsidiaries, (ii) any general partnership,
joint venture or similar entity, at least a majority of whose outstanding partnership or similar interests shall at the time be owned
by such Person, or by one or more of its Subsidiaries, or by such Person and one or more of its Subsidiaries and (iii) any limited partnership
of which such Person or any of its Subsidiaries is a general partner.
“Trustee” means , and, subject to the
provisions of Article Seven, shall also include its successors and assigns, and, if at any time there is more than one Person acting in
such capacity hereunder, “Trustee” shall mean each such Person. The term “Trustee” as used with respect to a particular
series of the Securities shall mean the trustee with respect to that series.
“Trust Indenture Act” means the Trust
Indenture Act of 1939, as amended.
“Voting Stock”, as applied to stock
of any Person, means shares, interests, participations or other equivalents in the equity interest (however designated) in such Person
having ordinary voting power for the election of a majority of the directors (or the equivalent) of such Person, other than shares, interests,
participations or other equivalents having such power only by reason of the occurrence of a contingency.
ARTICLE 2
ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION
AND
EXCHANGE OF SECURITIES
Section 2.01 Designation and Terms of Securities
..
(a) The aggregate principal amount of Securities
that may be authenticated and delivered under this Indenture is unlimited. The Securities may be issued in one or more series up to the
aggregate principal amount of Securities of that series from time to time authorized by or pursuant to a Board Resolution or pursuant
to one or more indentures supplemental hereto. Prior to the initial issuance of Securities of any series, there shall be established in
or pursuant to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental hereto:
(1) the title of the Securities of the series (which
shall distinguish the Securities of that series from all other Securities);
(2) any limit upon the aggregate principal amount
of the Securities of that series that may be authenticated and delivered under this Indenture (except for Securities authenticated and
delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities of that series);
(3) the date or dates on which the principal of
the Securities of the series is payable, any original issue discount that may apply to the Securities of that series upon their issuance,
the principal amount due at maturity, and the place(s) of payment;
(4) the rate or rates at which the Securities of
the series shall bear interest or the manner of calculation of such rate or rates, if any;
(5) the date or dates from which such interest shall
accrue, the Interest Payment Dates on which such interest will be payable or the manner of determination of such Interest Payment Dates,
the place(s) of payment, and the record date for the determination of holders to whom interest is payable on any such Interest Payment
Dates or the manner of determination of such record dates;
(6) the right, if any, to extend the interest payment
periods and the duration of such extension;
(7) the period or periods within which, the price
or prices at which and the terms and conditions upon which Securities of the series may be redeemed, in whole or in part, at the option
of the Company;
(8) the obligation, if any, of the Company to redeem
or purchase Securities of the series pursuant to any sinking fund, mandatory redemption, or analogous provisions (including payments made
in cash in satisfaction of future sinking fund obligations) or at the option of a holder thereof and the period or periods within which,
the price or prices at which, and the terms and conditions upon which, Securities of the series shall be redeemed or purchased, in whole
or in part, pursuant to such obligation;
(9) the form of the Securities of the series including
the form of the Certificate of Authentication for such series;
(10) if other than denominations of one thousand
U.S. dollars ($1,000) or any integral multiple thereof, the denominations in which the Securities of the series shall be issuable;
(11) any and all other terms (including terms, to
the extent applicable, relating to any auction or remarketing of the Securities of that series and any security for the obligations of
the Company with respect to such Securities) with respect to such series (which terms shall not be inconsistent with the terms of this
Indenture, as amended by any supplemental indenture) including any terms which may be required by or advisable under United States laws
or regulations or advisable in connection with the marketing of Securities of that series;
(12) whether the Securities are issuable as a Global
Security and, in such case, the terms and the identity of the Depositary for such series;
(13) whether the Securities will be convertible
into or exchangeable for shares of common stock, preferred stock or other securities of the Company or any other Person and, if so, the
terms and conditions upon which such Securities will be so convertible or exchangeable, including the conversion or exchange price, as
applicable, or how it will be calculated and may be adjusted, any mandatory or optional (at the Company’s option or the holders’ option)
conversion or exchange features, and the applicable conversion or exchange period;
(14) if other than the principal amount thereof,
the portion of the principal amount of Securities of the series which shall be payable upon declaration of acceleration of the maturity
thereof pursuant to Section 6.01;
(15) any additional or different Events of Default
or restrictive covenants (which may include, among other restrictions, restrictions on the Company’s ability or the ability of the Company’s
Subsidiaries to: incur additional indebtedness; issue additional securities; create liens; pay dividends or make distributions in respect
of the capital stock of the Company or the Company’s Subsidiaries; redeem capital stock; place restrictions on the Company’s Subsidiaries’
ability to pay dividends, make distributions or transfer assets; make investments or other restricted payments; sell or otherwise dispose
of assets; enter into sale-leaseback transactions; engage in transactions with stockholders or affiliates; issue or sell stock of the
Company’s Subsidiaries; or effect a consolidation or merger) or financial covenants (which may include, among other financial covenants,
financial covenants that require the Company and its Subsidiaries to maintain specified interest coverage, fixed charge, cash flow-based,
asset-based or other financial ratios) provided for with respect to the Securities of the series;
(16) if other than dollars, the coin or currency
in which the Securities of the series are denominated (including, but not limited to, foreign currency);
(17) the terms and conditions, if any, upon which
the Company shall pay amounts in addition to the stated interest, premium, if any and principal amounts of the Securities of the series
to any Securityholder that is not a “United States person” for federal tax purposes;
(18) any restrictions on transfer, sale or assignment
of the Securities of the series; and
(19) the subordination terms of the Securities of
the series.
All Securities of any one series shall be substantially
identical except as may otherwise be provided in or pursuant to any such Board Resolution or in any indentures supplemental hereto.
If any of the terms of the series are established
by action taken pursuant to a Board Resolution of the Company, a copy of an appropriate record of such action shall be certified by the
secretary or an assistant secretary of the Company and delivered to the Trustee at or prior to the delivery of the Officer’s Certificate
of the Company setting forth the terms of the series.
Securities of any particular series may be issued
at various times, with different dates on which the principal or any installment of principal is payable, with different rates of interest,
if any, or different methods by which rates of interest may be determined, with different dates on which such interest may be payable
and with different redemption dates.
Section 2.02 Form of Securities and Trustee’s
Certificate .
The Securities of any series and the Trustee’s
certificate of authentication to be borne by such Securities shall be substantially of the tenor and purport as set forth in one or more
indentures supplemental hereto or as provided in a Board Resolution, and set forth in an Officer’s Certificate, and they may have such
letters, numbers or other marks of identification or designation and such legends or endorsements printed, lithographed or engraved thereon
as the Company may deem appropriate and as are not inconsistent with the provisions of this Indenture, or as may be required to comply
with any law or with any rule or regulation made pursuant thereto or with any rule or regulation of any securities exchange on which Securities
of that series may be listed, or to conform to usage.
Section 2.03 Denominations: Provisions for
Payment .
The Securities shall be
issuable as registered Securities and in the denominations of one thousand U.S. dollars ($1,000) or any integral multiple thereof,
subject to Section 2.01(a)(10). The Securities of a particular series shall bear interest payable on the dates and at the rate
specified with respect to that series. Subject to Section 2.01(a)(16), the principal of and the interest on the Securities of any
series, as well as any premium thereon in case of redemption thereof prior to maturity, shall be payable in the coin or currency of
the United States of America that at the time is legal tender for public and private debt, at the office or agency of the Company
maintained for that purpose. Each Security shall be dated the date of its authentication. Interest on the Securities shall be
computed on the basis of a 360-day year composed of twelve 30-day months.
The interest installment on any Security that
is payable, and is punctually paid or duly provided for, on any Interest Payment Date for Securities of that series shall be paid to the
Person in whose name said Security (or one or more Predecessor Securities) is registered at the close of business on the regular record
date for such interest installment. In the event that any Security of a particular series or portion thereof is called for redemption
and the redemption date is subsequent to a regular record date with respect to any Interest Payment Date and prior to such Interest Payment
Date, interest on such Security will be paid upon presentation and surrender of such Security as provided in Section 3.03.
Any interest on any Security that is payable,
but is not punctually paid or duly provided for, on any Interest Payment Date for Securities of the same series (herein called “Defaulted
Interest”) shall forthwith cease to be payable to the registered holder on the relevant regular record date by virtue of having been
such holder; and such Defaulted Interest shall be paid by the Company, at its election, as provided in clause (1) or clause (2) below:
(1) The Company may make payment of any Defaulted
Interest on Securities to the Persons in whose names such Securities (or their respective Predecessor Securities) are registered at the
close of business on a special record date for the payment of such Defaulted Interest, which shall be fixed in the following manner: the
Company shall notify the Trustee in writing of the amount of Defaulted Interest proposed to be paid on each such Security and the date
of the proposed payment, and at the same time the Company shall deposit with the Trustee an amount of money equal to the aggregate amount
proposed to be paid in respect of such Defaulted Interest or shall make arrangements satisfactory to the Trustee for such deposit prior
to the date of the proposed payment, such money when deposited to be held in trust for the benefit of the Persons entitled to such Defaulted
Interest as in this clause provided. Thereupon the Trustee shall fix a special record date for the payment of such Defaulted Interest
which shall not be more than 15 nor less than 10 days prior to the date of the proposed payment and not less than 10 days after the receipt
by the Trustee of the notice of the proposed payment. The Trustee shall promptly notify the Company of such special record date and, in
the name and at the expense of the Company, shall cause notice of the proposed payment of such Defaulted Interest and the special record
date therefor to be mailed, first class postage prepaid, to each Securityholder at his or her address as it appears in the Security Register
(as hereinafter defined), not less than 10 days prior to such special record date. Notice of the proposed payment of such Defaulted Interest
and the special record date therefor having been mailed as aforesaid, such Defaulted Interest shall be paid to the Persons in whose names
such Securities (or their respective Predecessor Securities) are registered on such special record date.
(2) The Company may make payment of any Defaulted
Interest on any Securities in any other lawful manner not inconsistent with the requirements of any securities exchange on which such
Securities may be listed, and upon such notice as may be required by such exchange, if, after notice given by the Company to the Trustee
of the proposed payment pursuant to this clause, such manner of payment shall be deemed practicable by the Trustee.
Unless otherwise set forth in a Board Resolution
or one or more indentures supplemental hereto establishing the terms of any series of Securities pursuant to Section 2.01 hereof, the
term “regular record date” as used in this Section with respect to a series of Securities and any Interest Payment Date for
such series shall mean either the fifteenth day of the month immediately preceding the month in which an Interest Payment Date established
for such series pursuant to Section 2.01 hereof shall occur, if such Interest Payment Date is the first day of a month, or the first day
of the month in which an Interest Payment Date established for such series pursuant to Section 2.01 hereof shall occur, if such Interest
Payment Date is the fifteenth day of a month, whether or not such date is a Business Day.
Subject to the foregoing provisions of this Section,
each Security of a series delivered under this Indenture upon transfer of or in exchange for or in lieu of any other Security of such
series shall carry the rights to interest accrued and unpaid, and to accrue, that were carried by such other Security.
Section 2.04 Execution and Authentications
..
The Securities shall be signed on behalf of the
Company by one of its Officers. Signatures may be in the form of a manual or facsimile signature.
The Company may use the facsimile signature of
any Person who shall have been an Officer, notwithstanding the fact that at the time the Securities shall be authenticated and delivered
or disposed of such Person shall have ceased to be such an officer of the Company. The Securities may contain such notations, legends
or endorsements required by law, stock exchange rule or usage. Each Security shall be dated the date of its authentication by the Trustee.
A Security shall not be valid until authenticated
manually by an authorized signatory of the Trustee, or by an Authenticating Agent. Such signature shall be conclusive evidence that the
Security so authenticated has been duly authenticated and delivered hereunder and that the holder is entitled to the benefits of this
Indenture. At any time and from time to time after the execution and delivery of this Indenture, the Company may deliver Securities of
any series executed by the Company to the Trustee for authentication, together with a written order of the Company for the authentication
and delivery of such Securities, signed by an Officer, and the Trustee in accordance with such written order shall authenticate and deliver
such Securities.
In authenticating such Securities and accepting
the additional responsibilities under this Indenture in relation to such Securities, the Trustee shall be entitled to receive, if requested,
and (subject to Section 7.01) shall be fully protected in relying upon, an Opinion of Counsel stating that the form and terms thereof
have been established in conformity with the provisions of this Indenture.
The Trustee shall not be required to authenticate
such Securities if the issue of such Securities pursuant to this Indenture will affect the Trustee’s own rights, duties or immunities
under the Securities and this Indenture or otherwise in a manner that is not reasonably acceptable to the Trustee.
Section 2.05 Registration of Transfer and Exchange
..
(a) Securities of any series may be exchanged
upon presentation thereof at the office or agency of the Company designated for such purpose, for other Securities of such series of authorized
denominations, and for a like aggregate principal amount, upon payment of a sum sufficient to cover any tax or other governmental charge
in relation thereto, all as provided in this Section. In respect of any Securities so surrendered for exchange, the Company shall execute,
the Trustee shall authenticate and such office or agency shall deliver in exchange therefor the Security or Securities of the same series
that the Securityholder making the exchange shall be entitled to receive, bearing numbers not contemporaneously outstanding.
(b) The Company shall keep, or cause to be kept,
at its office or agency designated for such purpose a register or registers (herein referred to as the “Security Register”)
in which, subject to such reasonable regulations as it may prescribe, the Company shall register the Securities and the transfers of Securities
as in this Article provided and which at all reasonable times shall be open for inspection by the Trustee. The registrar for the purpose
of registering Securities and transfer of Securities as herein provided shall be appointed as authorized by Board Resolution (the “Security
Registrar”).
Upon surrender for transfer of any Security at
the office or agency of the Company designated for such purpose, the Company shall execute, the Trustee shall authenticate and such office
or agency shall deliver in the name of the transferee or transferees a new Security or Securities of the same series as the Security presented
for a like aggregate principal amount.
All Securities presented or surrendered for exchange
or registration of transfer, as provided in this Section, shall be accompanied (if so required by the Company or the Security Registrar)
by a written instrument or instruments of transfer, in form satisfactory to the Company or the Security Registrar, duly executed by the
registered holder or by such holder’s duly authorized attorney in writing.
(c) Except as provided pursuant to Section 2.01
pursuant to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental to this
Indenture, no service charge shall be made for any exchange or registration of transfer of Securities, or issue of new Securities in case
of partial redemption of any series, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge
in relation thereto, other than exchanges pursuant to Section 2.06, Section 3.03(b) and Section 9.04 not involving any transfer.
(d) The Company shall not be required (i) to issue,
exchange or register the transfer of any Securities during a period beginning at the opening of business 15 days before the day of the
mailing of a notice of redemption of less than all the Outstanding Securities of the same series and ending at the close of business on
the day of such mailing, nor (ii) to register the transfer of or exchange any Securities of any series or portions thereof called for
redemption, other than the unredeemed portion of any such Securities being redeemed in part. The provisions of this Section 2.05 are,
with respect to any Global Security, subject to Section 2.11 hereof.
Section 2.06 Temporary Securities .
Pending the preparation of definitive
Securities of any series, the Company may execute, and the Trustee shall authenticate and deliver, temporary Securities (printed,
lithographed or typewritten) of any authorized denomination. Such temporary Securities shall be substantially in the form of the
definitive Securities in lieu of which they are issued, but with such omissions, insertions and variations as may be appropriate for
temporary Securities, all as may be determined by the Company. Every temporary Security of any series shall be executed by the
Company and be authenticated by the Trustee upon the same conditions and in substantially the same manner, and with like effect, as
the definitive Securities of such series. Without unnecessary delay the Company will execute and will furnish definitive Securities
of such series and thereupon any or all temporary Securities of such series may be surrendered in exchange therefor (without charge
to the holders), at the office or agency of the Company designated for the purpose, and the Trustee shall authenticate and such
office or agency shall deliver in exchange for such temporary Securities an equal aggregate principal amount of definitive
Securities of such series, unless the Company advises the Trustee to the effect that definitive Securities need not be executed and
furnished until further notice from the Company. Until so exchanged, the temporary Securities of such series shall be entitled to
the same benefits under this Indenture as definitive Securities of such series authenticated and delivered hereunder.
Section 2.07 Mutilated, Destroyed, Lost or
Stolen Securities .
In case any temporary or definitive Security shall
become mutilated or be destroyed, lost or stolen, the Company (subject to the next succeeding sentence) shall execute, and upon the Company’s
request the Trustee (subject as aforesaid) shall authenticate and deliver, a new Security of the same series, bearing a number not contemporaneously
outstanding, in exchange and substitution for the mutilated Security, or in lieu of and in substitution for the Security so destroyed,
lost or stolen. In every case the applicant for a substituted Security shall furnish to the Company and the Trustee such security or indemnity
as may be required by them to save each of them harmless, and, in every case of destruction, loss or theft, the applicant shall also furnish
to the Company and the Trustee evidence to their satisfaction of the destruction, loss or theft of the applicant’s Security and of the
ownership thereof. The Trustee may authenticate any such substituted Security and deliver the same upon the written request or authorization
of any officer of the Company. Upon the issuance of any substituted Security, the Company may require the payment of a sum sufficient
to cover any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses
of the Trustee) connected therewith.
In case any Security that has matured or is about
to mature shall become mutilated or be destroyed, lost or stolen, the Company may, instead of issuing a substitute Security, pay or authorize
the payment of the same (without surrender thereof except in the case of a mutilated Security) if the applicant for such payment shall
furnish to the Company and the Trustee such security or indemnity as they may require to save them harmless, and, in case of destruction,
loss or theft, evidence to the satisfaction of the Company and the Trustee of the destruction, loss or theft of such Security and of the
ownership thereof.
Every replacement Security issued pursuant to
the provisions of this Section shall constitute an additional contractual obligation of the Company whether or not the mutilated, destroyed,
lost or stolen Security shall be found at any time, or be enforceable by anyone, and shall be entitled to all the benefits of this Indenture
equally and proportionately with any and all other Securities of the same series duly issued hereunder. All Securities shall be held and
owned upon the express condition that the foregoing provisions are exclusive with respect to the replacement or payment of mutilated,
destroyed, lost or stolen Securities, and shall preclude (to the extent lawful) any and all other rights or remedies, notwithstanding
any law or statute existing or hereafter enacted to the contrary with respect to the replacement or payment of negotiable instruments
or other securities without their surrender.
Section 2.08 Cancellation .
All Securities surrendered for the purpose of
payment, redemption, exchange or registration of transfer shall, if surrendered to the Company or any paying agent, be delivered to the
Trustee for cancellation, or, if surrendered to the Trustee, shall be cancelled by it, and no Securities shall be issued in lieu thereof
except as expressly required or permitted by any of the provisions of this Indenture. On request of the Company at the time of such surrender,
the Trustee shall deliver to the Company canceled Securities held by the Trustee. In the absence of such request the Trustee may dispose
of canceled Securities in accordance with its standard procedures and deliver a certificate of disposition to the Company. If the Company
shall otherwise acquire any of the Securities, however, such acquisition shall not operate as a redemption or satisfaction of the indebtedness
represented by such Securities unless and until the same are delivered to the Trustee for cancellation.
Section 2.09 Benefits of Indenture .
Nothing in this
Indenture or in the Securities, express or implied, shall give or be construed to give to any Person, other than the parties hereto
and the holders of the Securities (and, with respect to the provisions of Article Fourteen, the holders of any indebtedness of the
Company to which the Securities of any series are subordinated) any legal or equitable right, remedy or claim under or in respect of
this Indenture, or under any covenant, condition or provision herein contained; all such covenants, conditions and provisions being
for the sole benefit of the parties hereto and of the holders of the Securities (and, with respect to the provisions of Article
Fourteen, the holders of any indebtedness of the Company to which the Securities of any series are subordinated).
Section 2.10 Authenticating Agent .
So long as any of the Securities of any series
remain Outstanding there may be an Authenticating Agent for any or all such series of Securities which the Trustee shall have the right
to appoint. Said Authenticating Agent shall be authorized to act on behalf of the Trustee to authenticate Securities of such series issued
upon exchange, transfer or partial redemption thereof, and Securities so authenticated shall be entitled to the benefits of this Indenture
and shall be valid and obligatory for all purposes as if authenticated by the Trustee hereunder. All references in this Indenture to the
authentication of Securities by the Trustee shall be deemed to include authentication by an Authenticating Agent for such series. Each
Authenticating Agent shall be acceptable to the Company and shall be a corporation that has a combined capital and surplus, as most recently
reported or determined by it, sufficient under the laws of any jurisdiction under which it is organized or in which it is doing business
to conduct a trust business, and that is otherwise authorized under such laws to conduct such business and is subject to supervision or
examination by federal or state authorities. If at any time any Authenticating Agent shall cease to be eligible in accordance with these
provisions, it shall resign immediately.
Any Authenticating Agent may at any time resign
by giving written notice of resignation to the Trustee and to the Company. The Trustee may at any time (and upon request by the Company
shall) terminate the agency of any Authenticating Agent by giving written notice of termination to such Authenticating Agent and to the
Company. Upon resignation, termination or cessation of eligibility of any Authenticating Agent, the Trustee may appoint an eligible successor
Authenticating Agent acceptable to the Company. Any successor Authenticating Agent, upon acceptance of its appointment hereunder, shall
become vested with all the rights, powers and duties of its predecessor hereunder as if originally named as an Authenticating Agent pursuant
hereto.
Section 2.11 Global Securities
..
(a) If the Company shall establish pursuant to
Section 2.01 that the Securities of a particular series are to be issued as a Global Security, then the Company shall execute and the
Trustee shall, in accordance with Section 2.04, authenticate and deliver, a Global Security that (i) shall represent, and shall be denominated
in an amount equal to the aggregate principal amount of, all of the Outstanding Securities of such series, (ii) shall be registered in
the name of the Depositary or its nominee, (iii) shall be delivered by the Trustee to the Depositary or pursuant to the Depositary’s instruction
and (iv) shall bear a legend substantially to the following effect: “Except as otherwise provided in Section 2.11 of the Indenture,
this Security may be transferred, in whole but not in part, only to another nominee of the Depositary or to a successor Depositary or
to a nominee of such successor Depositary.”
(b) Notwithstanding the provisions of Section
2.05, the Global Security of a series may be transferred, in whole but not in part and in the manner provided in Section 2.05, only to
another nominee of the Depositary for such series, or to a successor Depositary for such series selected or approved by the Company or
to a nominee of such successor Depositary.
(c) If at any time the
Depositary for a series of the Securities notifies the Company that it is unwilling or unable to continue as Depositary for such
series or if at any time the Depositary for such series shall no longer be registered or in good standing under the Exchange Act, or
other applicable statute or regulation, and a successor Depositary for such series is not appointed by the Company within 90 days
after the Company receives such notice or becomes aware of such condition, as the case may be, or if an Event of Default has
occurred and is continuing and the Company has received a request from the Depositary or from the Trustee, this Section 2.11 shall
no longer be applicable to the Securities of such series and the Company will execute, and subject to Section 2.04, the Trustee will
authenticate and deliver the Securities of such series in definitive registered form without coupons, in authorized denominations,
and in an aggregate principal amount equal to the principal amount of the Global Security of such series in exchange for such Global
Security. In addition, the Company may at any time determine that the Securities of any series shall no longer be represented by a
Global Security and that the provisions of this Section 2.11 shall no longer apply to the Securities of such series. In such event
the Company will execute and, subject to Section 2.04, the Trustee, upon receipt of an Officer’s Certificate evidencing such
determination by the Company, will authenticate and deliver the Securities of such series in definitive registered form without
coupons, in authorized denominations, and in an aggregate principal amount equal to the principal amount of the Global Security of
such series in exchange for such Global Security. Upon the exchange of the Global Security for such Securities in definitive
registered form without coupons, in authorized denominations, the Global Security shall be canceled by the Trustee. Such Securities
in definitive registered form issued in exchange for the Global Security pursuant to this Section 2.11(c) shall be registered in
such names and in such authorized denominations as the Depositary, pursuant to instructions from its direct or indirect participants
or otherwise, shall instruct the Trustee. The Trustee shall deliver such Securities to the Depositary for delivery to the Persons in
whose names such Securities are so registered.
ARTICLE 3
REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS
Section 3.01 Redemption.
The Company may redeem the Securities of any series
issued hereunder on and after the dates and in accordance with the terms established for such series pursuant to Section 2.01 hereof.
Section 3.02 Notice of Redemption .
(a) In case the Company shall desire to exercise
such right to redeem all or, as the case may be, a portion of the Securities of any series in accordance with any right the Company reserved
for itself to do so pursuant to Section 2.01 hereof, the Company shall, or shall cause the Trustee to, give notice of such redemption
to holders of the Securities of such series to be redeemed by mailing, first class postage prepaid, a notice of such redemption not less
than 30 days and not more than 90 days before the date fixed for redemption of that series to such holders at their last addresses as
they shall appear upon the Security Register, unless a shorter period is specified in the Securities to be redeemed. Any notice that is
mailed in the manner herein provided shall be conclusively presumed to have been duly given, whether or not the registered holder receives
the notice. In any case, failure duly to give such notice to the holder of any Security of any series designated for redemption in whole
or in part, or any defect in the notice, shall not affect the validity of the proceedings for the redemption of any other Securities of
such series or any other series. In the case of any redemption of Securities prior to the expiration of any restriction on such redemption
provided in the terms of such Securities or elsewhere in this Indenture, the Company shall furnish the Trustee with an Officer’s Certificate
evidencing compliance with any such restriction.
Each such notice of redemption shall specify the
date fixed for redemption and the redemption price at which Securities of that series are to be redeemed, and shall state that payment
of the redemption price of such Securities to be redeemed will be made at the office or agency of the Company, upon presentation and surrender
of such Securities, that interest accrued to the date fixed for redemption will be paid as specified in said notice, that from and after
said date interest will cease to accrue and that the redemption is from a sinking fund, if such is the case. If less than all the Securities
of a series are to be redeemed, the notice to the holders of Securities of that series to be redeemed in part shall specify the particular
Securities to be so redeemed.
In case any Security is to be redeemed in part
only, the notice that relates to such Security shall state the portion of the principal amount thereof to be redeemed, and shall state
that on and after the redemption date, upon surrender of such Security, a new Security or Securities of such series in principal amount
equal to the unredeemed portion thereof will be issued.
(b) If less than all the
Securities of a series are to be redeemed, the Company shall give the Trustee at least 45 days’ notice (unless a shorter notice shall
be satisfactory to the Trustee) in advance of the date fixed for redemption as to the aggregate principal amount of Securities of the
series to be redeemed, and thereupon the Trustee shall select, by lot or in such other manner as it shall deem appropriate and fair in
its discretion and that may provide for the selection of a portion or portions (equal to one thousand U.S. dollars ($1,000) or any integral
multiple thereof) of the principal amount of such Securities of a denomination larger than $1,000, the Securities to be redeemed and
shall thereafter promptly notify the Company in writing of the numbers of the Securities to be redeemed, in whole or in part. The Company
may, if and whenever it shall so elect, by delivery of instructions signed on its behalf by an Officer, instruct the Trustee or any paying
agent to call all or any part of the Securities of a particular series for redemption and to give notice of redemption in the manner
set forth in this Section, such notice to be in the name of the Company or its own name as the Trustee or such paying agent may deem
advisable. In any case in which notice of redemption is to be given by the Trustee or any such paying agent, the Company shall deliver
or cause to be delivered to, or permit to remain with, the Trustee or such paying agent, as the case may be, such Security Register,
transfer books or other records, or suitable copies or extracts therefrom, sufficient to enable the Trustee or such paying agent to give
any notice by mail that may be required under the provisions of this Section.
Section 3.03 Payment Upon Redemption .
(a) If the giving of notice of redemption shall
have been completed as above provided, the Securities or portions of Securities of the series to be redeemed specified in such notice
shall become due and payable on the date and at the place stated in such notice at the applicable redemption price, together with interest
accrued to the date fixed for redemption and interest on such Securities or portions of Securities shall cease to accrue on and after
the date fixed for redemption, unless the Company shall default in the payment of such redemption price and accrued interest with respect
to any such Security or portion thereof. On presentation and surrender of such Securities on or after the date fixed for redemption at
the place of payment specified in the notice, said Securities shall be paid and redeemed at the applicable redemption price for such series,
together with interest accrued thereon to the date fixed for redemption (but if the date fixed for redemption is an interest payment date,
the interest installment payable on such date shall be payable to the registered holder at the close of business on the applicable record
date pursuant to Section 2.03).
(b) Upon presentation of any Security of such
series that is to be redeemed in part only, the Company shall execute and the Trustee shall authenticate and the office or agency where
the Security is presented shall deliver to the holder thereof, at the expense of the Company, a new Security of the same series of authorized
denominations in principal amount equal to the unredeemed portion of the Security so presented.
Section 3.04 Sinking Fund .
The provisions of Sections 3.04, 3.05 and 3.06
shall be applicable to any sinking fund for the retirement of Securities of a series, except as otherwise specified as contemplated by
Section 2.01 for Securities of such series.
The minimum amount of any sinking fund payment
provided for by the terms of Securities of any series is herein referred to as a “mandatory sinking fund payment,” and any payment
in excess of such minimum amount provided for by the terms of Securities of any series is herein referred to as an “optional sinking
fund payment”. If provided for by the terms of Securities of any series, the cash amount of any sinking fund payment may be subject
to reduction as provided in Section 3.05. Each sinking fund payment shall be applied to the redemption of Securities of any series as
provided for by the terms of Securities of such series.
Section 3.05 Satisfaction of Sinking Fund Payments
with Securities .
The Company (i) may deliver Outstanding Securities
of a series and (ii) may apply as a credit Securities of a series that have been redeemed either at the election of the Company pursuant
to the terms of such Securities or through the application of permitted optional sinking fund payments pursuant to the terms of such Securities,
in each case in satisfaction of all or any part of any sinking fund payment with respect to the Securities of such series required to
be made pursuant to the terms of such Securities as provided for by the terms of such series, provided that such Securities have not been
previously so credited. Such Securities shall be received and credited for such purpose by the Trustee at the redemption price specified
in such Securities for redemption through operation of the sinking fund and the amount of such sinking fund payment shall be reduced accordingly.
Section 3.06 Redemption of Securities for Sinking
Fund .
Not less than 45 days prior to each sinking fund
payment date for any series of Securities (unless a shorter period shall be satisfactory to the Trustee), the Company will deliver to
the Trustee an Officer’s Certificate specifying the amount of the next ensuing sinking fund payment for that series pursuant to the terms
of the series, the portion thereof, if any, that is to be satisfied by delivering and crediting Securities of that series pursuant to
Section 3.05 and the basis for such credit and will, together with such Officer’s Certificate, deliver to the Trustee any Securities to
be so delivered. Not less than 30 days before each such sinking fund payment date the Trustee shall select the Securities to be redeemed
upon such sinking fund payment date in the manner specified in Section 3.02 and cause notice of the redemption thereof to be given in
the name of and at the expense of the Company in the manner provided in Section 3.02. Such notice having been duly given, the redemption
of such Securities shall be made upon the terms and in the manner stated in Section 3.03.
ARTICLE 4
COVENANTS
Section 4.01 Payment of Principal, Premium
and Interest .
The Company will duly
and punctually pay or cause to be paid the principal of (and premium, if any) and interest on the Securities of that series at the
time and place and in the manner provided herein and established with respect to such Securities. Payments of principal on the
Securities may be made at the time provided herein and established with respect to such Securities by U.S. dollar check drawn on and
mailed to the address of the Securityholder entitled thereto as such address shall appear in the Security Register, or U.S. dollar
wire transfer to, a U.S. dollar account (such wire transfer to be made only to a Securityholder of an aggregate principal amount of
Securities of the applicable series in excess of U.S. $2,000,000 and only if such Securityholder shall have furnished wire
instructions to the Trustee no later than 15 days prior to the relevant payment date). Payments of interest on the Securities may be
made at the time provided herein and established with respect to such Securities by U.S. dollar check mailed to the address of the
Securityholder entitled thereto as such address shall appear in the Security Register, or U.S. dollar wire transfer to, a U.S.
dollar account (such a wire transfer to be made only to a Securityholder of an aggregate principal amount of Securities of the
applicable series in excess of U.S. $2,000,000 and only if such Securityholder shall have furnished wire instructions in writing to
the Security Registrar and the Trustee no later than 15 days prior to the relevant payment date.
Section 4.02 Maintenance of Office
or Agency .
So long as any series of the Securities remain Outstanding, the Company
agrees to maintain an office or agency with respect to each such series and at such other location or locations as may be designated as
provided in this Section 4.02, where (i) Securities of that series may be presented for payment, (ii) Securities of that series may be
presented as herein above authorized for registration of transfer and exchange, and (iii) notices and demands to or upon the Company in
respect of the Securities of that series and this Indenture may be given or served, such designation to continue with respect to such
office or agency until the Company shall, by written notice signed by any officer authorized to sign an Officer’s Certificate and delivered
to the Trustee, designate some other office or agency for such purposes or any of them. If at any time the Company shall fail to maintain
any such required office or agency or shall fail to furnish the Trustee with the address thereof, such presentations, notices and demands
may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the Trustee as its agent to receive
all such presentations, notices and demands. The Company initially appoints the Corporate Trust Office of the Trustee as its paying agent
with respect to the Securities.
Section 4.03 Paying Agents .
(a) If the Company shall appoint one or more paying
agents for all or any series of the Securities, other than the Trustee, the Company will cause each such paying agent to execute and deliver
to the Trustee an instrument in which such agent shall agree with the Trustee, subject to the provisions of this Section:
(1) that it will hold all sums held by it as such
agent for the payment of the principal of (and premium, if any) or interest on the Securities of that series (whether such sums have been
paid to it by the Company or by any other obligor of such Securities) in trust for the benefit of the Persons entitled thereto;
(2) that it will give the Trustee notice of any
failure by the Company (or by any other obligor of such Securities) to make any payment of the principal of (and premium, if any) or interest
on the Securities of that series when the same shall be due and payable;
(3) that it will, at any time during the continuance
of any failure referred to in the preceding paragraph (a)(2) above, upon the written request of the Trustee, forthwith pay to the Trustee
all sums so held in trust by such paying agent; and
(4) that it will perform all other duties of paying
agent as set forth in this Indenture.
(b) If the Company shall
act as its own paying agent with respect to any series of the Securities, it will on or before each due date of the principal of (and
premium, if any) or interest on Securities of that series, set aside, segregate and hold in trust for the benefit of the Persons entitled
thereto a sum sufficient to pay such principal (and premium, if any) or interest so becoming due on Securities of that series until such
sums shall be paid to such Persons or otherwise disposed of as herein provided and will promptly notify the Trustee of such action, or
any failure (by it or any other obligor on such Securities) to take such action. Whenever the Company shall have one or more paying agents
for any series of Securities, it will, prior to each due date of the principal of (and premium, if any) or interest on any Securities
of that series, deposit with the paying agent a sum sufficient to pay the principal (and premium, if any) or interest so becoming due,
such sum to be held in trust for the benefit of the Persons entitled to such principal, premium or interest, and (unless such paying
agent is the Trustee) the Company will promptly notify the Trustee of this action or failure so to act.
(c) Notwithstanding anything in this Section to
the contrary, (i) the agreement to hold sums in trust as provided in this Section is subject to the provisions of Section 11.05, and (ii)
the Company may at any time, for the purpose of obtaining the satisfaction and discharge of this Indenture or for any other purpose, pay,
or direct any paying agent to pay, to the Trustee all sums held in trust by the Company or such paying agent, such sums to be held by
the Trustee upon the same terms and conditions as those upon which such sums were held by the Company or such paying agent; and, upon
such payment by the Company or any paying agent to the Trustee, the Company or such paying agent shall be released from all further liability
with respect to such money.
Section 4.04 Appointment to Fill
Vacancy in Office of Trustee .
The Company, whenever necessary to avoid or fill
a vacancy in the office of Trustee, will appoint, in the manner provided in Section 7.10, a Trustee, so that there shall at all times
be a Trustee hereunder.
Section 4.05 Compliance with Consolidation
Provisions .
The Company will not, while any of the Securities
remain Outstanding, consolidate with or merge into any other Person, in either case where the Company is not the survivor of such transaction,
or sell or convey all or substantially all of its property to any other Person unless the provisions of Article Ten hereof are complied
with.
ARTICLE 5
SECURITYHOLDERS’ LISTS AND REPORTS BY THE COMPANY
AND THE TRUSTEE
Section 5.01 Company to Furnish Trustee Names
and Addresses of Securityholders .
The Company will furnish or cause to be furnished
to the Trustee (a) within 15 days after each regular record date (as defined in Section 2.03) a list, in such form as the Trustee may
reasonably require, of the names and addresses of the holders of each series of Securities as of such regular record date, provided that
the Company shall not be obligated to furnish or cause to furnish such list at any time that the list shall not differ in any respect
from the most recent list furnished to the Trustee by the Company and (b) at such other times as the Trustee may request in writing within
30 days after the receipt by the Company of any such request, a list of similar form and content as of a date not more than 15 days prior
to the time such list is furnished; provided, however, that, in either case, no such list need be furnished for any series for which the
Trustee shall be the Security Registrar.
Section 5.02 Preservation Of Information; Communications
With Securityholders .
(a) The Trustee shall preserve, in as current
a form as is reasonably practicable, all information as to the names and addresses of the holders of Securities contained in the most
recent list furnished to it as provided in Section 5.01 and as to the names and addresses of holders of Securities received by the Trustee
in its capacity as Security Registrar (if acting in such capacity).
(b) The Trustee may destroy any list furnished
to it as provided in Section 5.01 upon receipt of a new list so furnished.
(c) Securityholders may communicate as provided
in Section 312(b) of the Trust Indenture Act with other Securityholders with respect to their rights under this Indenture or under the
Securities, and, in connection with any such communications, the Trustee shall satisfy its obligations under Section 312(b) of the Trust
Indenture Act in accordance with the provisions of Section 312(b) of the Trust Indenture Act.
Section 5.03 Reports by the Company .
The Company covenants and agrees to provide
(which delivery may be via electronic mail) to the Trustee, after the Company files the same with the Securities and Exchange
Commission, copies of the annual reports and of the information, documents and other reports (or copies of such portions of any of
the foregoing as the Securities and Exchange Commission may from time to time by rules and regulations prescribe) that the Company
files with the Securities and Exchange Commission pursuant to Section 13 or Section 15(d) of the Exchange Act; provided, however,
the Company shall not be required to deliver to the Trustee any materials for which the Company has sought and received confidential
treatment by the Securities and Exchange Commission; and provided further, so long as such filings by the Company are available on
the Securities and Exchange Commission’s Electronic Data Gathering, Analysis and Retrieval System (EDGAR), such filings shall be
deemed to have been filed with the Trustee for purposes of this Section 5.03 without any further action required by the Company.
Section 5.04 Reports by the Trustee
..
(a) If required by Section 313(a) of the Trust
Indenture Act, the Trustee, within sixty (60) days after each May 1, shall transmit by mail, first class postage prepaid, to the Securityholders,
as their names and addresses appear upon the Security Register, a brief report dated as of such May 1, which complies with Section 313(a)
of the Trust Indenture Act.
(b) The Trustee shall comply with Section 313(b)
and 313(c) of the Trust Indenture Act.
(c) A copy of each such report shall, at the time
of such transmission to Securityholders, be filed by the Trustee with the Company, with each securities exchange upon which any Securities
are listed (if so listed) and also with the Securities and Exchange Commission. The Company agrees to notify the Trustee when any Securities
become listed on any securities exchange.
ARTICLE 6
REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS
ON EVENT OF DEFAULT
Section 6.01 Events of Default .
(a) Whenever used herein with respect to Securities
of a particular series, “Event of Default” means any one or more of the following events that has occurred and is continuing:
(1) the Company defaults in the payment of any installment
of interest upon any of the Securities of that series, as and when the same shall become due and payable, and such default continues for
a period of 90 days; provided, however, that a valid extension of an interest payment period by the Company in accordance with the terms
of any indenture supplemental hereto shall not constitute a default in the payment of interest for this purpose;
(2) the Company defaults in the payment of the principal
of (or premium, if any, on) any of the Securities of that series as and when the same shall become due and payable whether at maturity,
upon redemption, by declaration or otherwise, or in any payment required by any sinking or analogous fund established with respect to
that series; provided, however, that a valid extension of the maturity of such Securities in accordance with the terms of any indenture
supplemental hereto shall not constitute a default in the payment of principal or premium, if any;
(3) the Company fails to observe or perform any
other of its covenants or agreements with respect to that series contained in this Indenture or otherwise established with respect to
that series of Securities pursuant to Section 2.01 hereof (other than a covenant or agreement that has been expressly included in this
Indenture solely for the benefit of one or more series of Securities other than such series) for a period of 90 days after the date on
which written notice of such failure, requiring the same to be remedied and stating that such notice is a “Notice of Default”
hereunder, shall have been given to the Company by the Trustee, by registered or certified mail, or to the Company and the Trustee by
the holders of at least 25% in principal amount of the Securities of that series at the time Outstanding;
(4) the Company pursuant to or within the meaning
of any Bankruptcy Law (i) commences a voluntary case, (ii) consents to the entry of an order for relief against it in an involuntary case,
(iii) consents to the appointment of a Custodian of it or for all or substantially all of its property or (iv) makes a general assignment
for the benefit of its creditors; or
(5) a court of competent jurisdiction enters an
order under any Bankruptcy Law that (i) is for relief against the Company in an involuntary case, (ii) appoints a Custodian of the Company
for all or substantially all of its property or (iii) orders the liquidation of the Company, and the order or decree remains unstayed
and in effect for 90 days.
(b) In each and every such
case (other than an Event of Default specified in clause (4) or clause (5) above), unless the principal of all the Securities of
that series shall have already become due and payable, either the Trustee or the holders of not less than 25% in aggregate principal
amount of the Securities of that series then Outstanding hereunder, by notice in writing to the Company (and to the Trustee if given
by such Securityholders), may declare the principal of (and premium, if any, on) and accrued and unpaid interest on all the
Securities of that series to be due and payable immediately, and upon any such declaration the same shall become and shall be
immediately due and payable. If an Event of Default specified in clause (4) or clause (5) above occurs, the principal of and accrued
and unpaid interest on all the Securities of that series shall automatically be immediately due and payable without any declaration
or other act on the part of the Trustee or the holders of the Securities.
(c) At any time after the principal of (and premium,
if any, on) and accrued and unpaid interest on the Securities of that series shall have been so declared due and payable, and before any
judgment or decree for the payment of the moneys due shall have been obtained or entered as hereinafter provided, the holders of a majority
in aggregate principal amount of the Securities of that series then Outstanding hereunder, by written notice to the Company and the Trustee,
may rescind and annul such declaration and its consequences if: (i) the Company has paid or deposited with the Trustee a sum sufficient
to pay all matured installments of interest upon all the Securities of that series and the principal of (and premium, if any, on) any
and all Securities of that series that shall have become due otherwise than by acceleration (with interest upon such principal and premium,
if any, and, to the extent that such payment is enforceable under applicable law, upon overdue installments of interest, at the rate per
annum expressed in the Securities of that series to the date of such payment or deposit) and the amount payable to the Trustee under Section
7.06, and (ii) any and all Events of Default under the Indenture with respect to such series, other than the nonpayment of principal on
(and premium, if any, on) and accrued and unpaid interest on Securities of that series that shall not have become due by their terms,
shall have been remedied or waived as provided in Section 6.06.
No such rescission and annulment shall extend
to or shall affect any subsequent default or impair any right consequent thereon.
(d) In case the Trustee shall have proceeded to
enforce any right with respect to Securities of that series under this Indenture and such proceedings shall have been discontinued or
abandoned because of such rescission or annulment or for any other reason or shall have been determined adversely to the Trustee, then
and in every such case, subject to any determination in such proceedings, the Company and the Trustee shall be restored respectively to
their former positions and rights hereunder, and all rights, remedies and powers of the Company and the Trustee shall continue as though
no such proceedings had been taken.
Section 6.02 Collection of Indebtedness and
Suits for Enforcement by Trustee .
(a) The Company covenants that (i) in case it
shall default in the payment of any installment of interest on any of the Securities of a series, or in any payment required by any sinking
or analogous fund established with respect to that series as and when the same shall have become due and payable, and such default shall
have continued for a period of 90 days, or (ii) in case it shall default in the payment of the principal of (or premium, if any, on) any
of the Securities of a series when the same shall have become due and payable, whether upon maturity of the Securities of a series or
upon redemption or upon declaration or otherwise then, upon demand of the Trustee, the Company will pay to the Trustee, for the benefit
of the holders of the Securities of that series, the whole amount that then shall have been become due and payable on all such Securities
for principal (and premium, if any) or interest, or both, as the case may be, with interest upon the overdue principal (and premium, if
any) and (to the extent that payment of such interest is enforceable under applicable law) upon overdue installments of interest at the
rate per annum expressed in the Securities of that series; and, in addition thereto, such further amount as shall be sufficient to cover
the costs and expenses of collection, and the amount payable to the Trustee under Section 7.06.
(b) If the Company shall fail to pay such amounts
forthwith upon such demand, the Trustee, in its own name and as trustee of an express trust, shall be entitled and empowered to institute
any action or proceedings at law or in equity for the collection of the sums so due and unpaid, and may prosecute any such action or proceeding
to judgment or final decree, and may enforce any such judgment or final decree against the Company or other obligor upon the Securities
of that series and collect the moneys adjudged or decreed to be payable in the manner provided by law or equity out of the property of
the Company or other obligor upon the Securities of that series, wherever situated.
(c) In case of any
receivership, insolvency, liquidation, bankruptcy, reorganization, readjustment, arrangement, composition or judicial proceedings
affecting the Company, or its creditors or property, the Trustee shall have power to intervene in such proceedings and take any
action therein that may be permitted by the court and shall (except as may be otherwise provided by law) be entitled to file such
proofs of claim and other papers and documents as may be necessary or advisable in order to have the claims of the Trustee and of
the holders of Securities of such series allowed for the entire amount due and payable by the Company under the Indenture at the
date of institution of such proceedings and for any additional amount that may become due and payable by the Company after such
date, and to collect and receive any moneys or other property payable or deliverable on any such claim, and to distribute the same
after the deduction of the amount payable to the Trustee under Section 7.06; and any receiver, assignee or trustee in bankruptcy or
reorganization is hereby authorized by each of the holders of Securities of such series to make such payments to the Trustee, and,
in the event that the Trustee shall consent to the making of such payments directly to such Securityholders, to pay to the Trustee
any amount due it under Section 7.06.
(d) All rights of action and of asserting claims
under this Indenture, or under any of the terms established with respect to Securities of that series, may be enforced by the Trustee
without the possession of any of such Securities, or the production thereof at any trial or other proceeding relative thereto, and any
such suit or proceeding instituted by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of
judgment shall, after provision for payment to the Trustee of any amounts due under Section 7.06, be for the ratable benefit of the holders
of the Securities of such series.
In case of an Event of Default hereunder, the
Trustee may in its discretion proceed to protect and enforce the rights vested in it by this Indenture by such appropriate judicial proceedings
as the Trustee shall deem most effectual to protect and enforce any of such rights, either at law or in equity or in bankruptcy or otherwise,
whether for the specific enforcement of any covenant or agreement contained in the Indenture or in aid of the exercise of any power granted
in this Indenture, or to enforce any other legal or equitable right vested in the Trustee by this Indenture or by law.
Nothing contained herein shall be deemed to authorize
the Trustee to authorize or consent to or accept or adopt on behalf of any Securityholder any plan of reorganization, arrangement, adjustment
or composition affecting the Securities of that series or the rights of any holder thereof or to authorize the Trustee to vote in respect
of the claim of any Securityholder in any such proceeding.
Section 6.03 Application of Moneys Collected
..
Any moneys collected by the Trustee pursuant to
this Article with respect to a particular series of Securities shall be applied in the following order, at the date or dates fixed by
the Trustee and, in case of the distribution of such moneys on account of principal (or premium, if any) or interest, upon presentation
of the Securities of that series, and notation thereon of the payment, if only partially paid, and upon surrender thereof if fully paid:
FIRST: To the payment of all indebtedness of the
Company to which such series of Securities is subordinated to the extent required by Section 7.06 and Article Fourteen;
SECOND: To the payment of the amounts then due
and unpaid upon Securities of such series for principal (and premium, if any) and interest, in respect of which or for the benefit of
which such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on
such Securities for principal (and premium, if any) and interest, respectively; and
THIRD: To the payment of the remainder, if any,
to the Company or any other Person lawfully entitled thereto.
Section 6.04 Limitation on Suits .
No holder of any Security of any series shall
have any right by virtue or by availing of any provision of this Indenture to institute any suit, action or proceeding in equity or at
law upon or under or with respect to this Indenture or for the appointment of a receiver or trustee, or for any other remedy hereunder,
unless (i) such holder previously shall have given to the Trustee written notice of an Event of Default and of the continuance thereof
with respect to the Securities of such series specifying such Event of Default, as hereinbefore provided; (ii) the holders of not less
than 25% in aggregate principal amount of the Securities of such series then Outstanding shall have made written request upon the Trustee
to institute such action, suit or proceeding in its own name as Trustee hereunder; (iii) such holder or holders shall have offered to
the Trustee such reasonable indemnity as it may require against the costs, expenses and liabilities to be incurred therein or thereby;
(iv) the Trustee for 90 days after its receipt of such notice, request and offer of indemnity, shall have failed to institute any such
action, suit or proceeding and (v) during such 90 day period, the holders of a majority in principal amount of the Securities of that
series do not give the Trustee a direction inconsistent with the request.
Notwithstanding
anything contained herein to the contrary or any other provisions of this Indenture, the right of any holder of any Security to
receive payment of the principal of (and premium, if any) and interest on such Security, as therein provided, on or after the
respective due dates expressed in such Security (or in the case of redemption, on the redemption date), or to institute suit for the
enforcement of any such payment on or after such respective dates or redemption date, shall not be impaired or affected without the
consent of such holder and by accepting a Security hereunder it is expressly understood, intended and covenanted by the taker and
holder of every Security of such series with every other such taker and holder and the Trustee, that no one or more holders of
Securities of such series shall have any right in any manner whatsoever by virtue or by availing of any provision of this Indenture
to affect, disturb or prejudice the rights of the holders of any other of such Securities, or to obtain or seek to obtain priority
over or preference to any other such holder, or to enforce any right under this Indenture, except in the manner herein provided and
for the equal, ratable and common benefit of all holders of Securities of such series. For the protection and enforcement of the
provisions of this Section, each and every Securityholder and the Trustee shall be entitled to such relief as can be given either at
law or in equity.
Section 6.05 Rights and Remedies Cumulative;
Delay or Omission Not Waiver .
(a) Except as otherwise provided in Section 2.07,
all powers and remedies given by this Article to the Trustee or to the Securityholders shall, to the extent permitted by law, be deemed
cumulative and not exclusive of any other powers and remedies available to the Trustee or the holders of the Securities, by judicial proceedings
or otherwise, to enforce the performance or observance of the covenants and agreements contained in this Indenture or otherwise established
with respect to such Securities.
(b) No delay or omission of the Trustee or of
any holder of any of the Securities to exercise any right or power accruing upon any Event of Default occurring and continuing as aforesaid
shall impair any such right or power, or shall be construed to be a waiver of any such default or an acquiescence therein; and, subject
to the provisions of Section 6.04, every power and remedy given by this Article or by law to the Trustee or the Securityholders may be
exercised from time to time, and as often as shall be deemed expedient, by the Trustee or by the Securityholders.
Section 6.06 Control by Securityholders
..
The holders of a majority in aggregate principal
amount of the Securities of any series at the time Outstanding, determined in accordance with Section 8.04, shall have the right to direct
the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred
on the Trustee with respect to such series; provided, however, that such direction shall not be in conflict with any rule of law or with
this Indenture. Subject to the provisions of Section 7.01, the Trustee shall have the right to decline to follow any such direction if
the Trustee in good faith shall, by a Responsible Officer or officers of the Trustee, determine that the proceeding so directed, subject
to the Trustee’s duties under the Trust Indenture Act, would involve the Trustee in personal liability or might be unduly prejudicial
to the Securityholders not involved in the proceeding. The holders of a majority in aggregate principal amount of the Securities of any
series at the time Outstanding affected thereby, determined in accordance with Section 8.04, may on behalf of the holders of all of the
Securities of such series waive any past default in the performance of any of the covenants contained herein or established pursuant to
Section 2.01 with respect to such series and its consequences, except a default in the payment of the principal of, or premium, if any,
or interest on, any of the Securities of that series as and when the same shall become due by the terms of such Securities otherwise than
by acceleration (unless such default has been cured and a sum sufficient to pay all matured installments of interest and principal and
any premium has been deposited with the Trustee (in accordance with Section 6.01(c)). Upon any such waiver, the default covered thereby
shall be deemed to be cured for all purposes of this Indenture and the Company, the Trustee and the holders of the Securities of such
series shall be restored to their former positions and rights hereunder, respectively; but no such waiver shall extend to any subsequent
or other default or impair any right consequent thereon.
Section 6.07 Undertaking to Pay Costs
..
All parties to this Indenture agree, and each
holder of any Securities by such holder’s acceptance thereof shall be deemed to have agreed, that any court may in its discretion require,
in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken or
omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and that such
court may in its discretion assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having
due regard to the merits and good faith of the claims or defenses made by such party litigant; but the provisions of this Section shall
not apply to any suit instituted by the Trustee, to any suit instituted by any Securityholder, or group of Securityholders, holding more
than 10% in aggregate principal amount of the Outstanding Securities of any series, or to any suit instituted by any Securityholder for
the enforcement of the payment of the principal of (or premium, if any) or interest on any Security of such series, on or after the respective
due dates expressed in such Security or established pursuant to this Indenture.
ARTICLE 7
CONCERNING THE TRUSTEE
Section 7.01 Certain Duties and Responsibilities
of Trustee .
(a) The Trustee, prior to the occurrence of an
Event of Default with respect to the Securities of a series and after the curing of all Events of Default with respect to the Securities
of that series that may have occurred, shall undertake to perform with respect to the Securities of such series such duties and only such
duties as are specifically set forth in this Indenture, and no implied covenants shall be read into this Indenture against the Trustee.
In case an Event of Default with respect to the Securities of a series has occurred (that has not been cured or waived), the Trustee shall
exercise with respect to Securities of that series such of the rights and powers vested in it by this Indenture, and use the same degree
of care and skill in their exercise, as a prudent man would exercise or use under the circumstances in the conduct of his own affairs.
(b) No provision of this Indenture shall be construed
to relieve the Trustee from liability for its own negligent action, its own negligent failure to act, or its own willful misconduct, except
that:
(i) prior to the occurrence of an Event of Default
with respect to the Securities of a series and after the curing or waiving of all such Events of Default with respect to that series that
may have occurred:(A) the duties and obligations of the Trustee shall with respect to the Securities of such series be determined solely
by the express provisions of this Indenture, and the Trustee shall not be liable with respect to the Securities of such series except
for the performance of such duties and obligations as are specifically set forth in this Indenture, and no implied covenants or obligations
shall be read into this Indenture against the Trustee; and (B) in the absence of bad faith on the part of the Trustee, the Trustee may
with respect to the Securities of such series conclusively rely, as to the truth of the statements and the correctness of the opinions
expressed therein, upon any certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture; but
in the case of any such certificates or opinions that by any provision hereof are specifically required to be furnished to the Trustee,
the Trustee shall be under a duty to examine the same to determine whether or not they conform to the requirements of this Indenture;
(ii) the Trustee shall not be liable for any error
of judgment made in good faith by a Responsible Officer or Responsible Officers of the Trustee, unless it shall be proved that the Trustee
was negligent in ascertaining the pertinent facts;
(iii) the Trustee shall not be liable with respect
to any action taken or omitted to be taken by it in good faith in accordance with the direction of the holders of not less than a majority
in principal amount of the Securities of any series at the time Outstanding relating to the time, method and place of conducting any proceeding
for any remedy available to the Trustee, or exercising any trust or power conferred upon the Trustee under this Indenture with respect
to the Securities of that series; and
(iv) None of the provisions contained in this
Indenture shall require the Trustee to expend or risk its own funds or otherwise incur personal financial liability in the performance
of any of its duties or in the exercise of any of its rights or powers if there is reasonable ground for believing that the repayment
of such funds or liability is not reasonably assured to it under the terms of this Indenture or adequate indemnity against such risk is
not reasonably assured to it.
Section 7.02 Certain Rights of Trustee
..
Except as otherwise provided in Section 7.01:
(a) The Trustee may rely and shall be protected
in acting or refraining from acting upon any resolution, certificate, statement, instrument, opinion, report, notice, request, consent,
order, approval, bond, security or other paper or document believed by it to be genuine and to have been signed or presented by the proper
party or parties;
(b) Any request, direction, order or demand of
the Company mentioned herein shall be sufficiently evidenced by a Board Resolution or an instrument signed in the name of the Company
by any authorized officer of the Company (unless other evidence in respect thereof is specifically prescribed herein);
(c) The Trustee may consult with counsel and the
written advice of such counsel or, if requested, any Opinion of Counsel shall be full and complete authorization and protection in respect
of any action taken or suffered or omitted hereunder in good faith and in reliance thereon;
(d) The Trustee shall be under no obligation to
exercise any of the rights or powers vested in it by this Indenture at the request, order or direction of any of the Securityholders pursuant
to the provisions of this Indenture, unless such Securityholders shall have offered to the Trustee reasonable security or indemnity against
the costs, expenses and liabilities that may be incurred therein or thereby; nothing contained herein shall, however, relieve the Trustee
of the obligation, upon the occurrence of an Event of Default with respect to a series of the Securities (that has not been cured or waived),
to exercise with respect to Securities of that series such of the rights and powers vested in it by this Indenture, and to use the same
degree of care and skill in their exercise, as a prudent man would exercise or use under the circumstances in the conduct of his own affairs;
(e) The Trustee shall not be liable for any action
taken or omitted to be taken by it in good faith and believed by it to be authorized or within the discretion or rights or powers conferred
upon it by this Indenture;
(f) The Trustee shall not be bound to make any
investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report, notice, request,
consent, order, approval, bond, security, or other papers or documents, unless requested in writing so to do by the holders of not less
than a majority in principal amount of the Outstanding Securities of the particular series affected thereby (determined as provided in
Section 8.04); provided, however, that if the payment within a reasonable time to the Trustee of the costs, expenses or liabilities likely
to be incurred by it in the making of such investigation is, in the opinion of the Trustee, not reasonably assured to the Trustee by the
security afforded to it by the terms of this Indenture, the Trustee may require reasonable indemnity against such costs, expenses or liabilities
as a condition to so proceeding. The reasonable expense of every such examination shall be paid by the Company or, if paid by the Trustee,
shall be repaid by the Company upon demand; and
(g) The Trustee may execute any of the trusts
or powers hereunder or perform any duties hereunder either directly or by or through agents or attorneys and the Trustee shall not be
responsible for any misconduct or negligence on the part of any agent or attorney appointed with due care by it hereunder.
In addition, the Trustee shall not be deemed to
have knowledge of any Default or Event of Default except (1) any Event of Default occurring pursuant to Sections 6.01(a)(1) and 6.01(a)(2)
or (2) any Default or Event of Default of which the Trustee shall have received written notification in the manner set forth in this Indenture
or a Responsible Officer of the Trustee shall have obtained actual knowledge. Delivery of reports, information and documents to the Trustee
under Section 5.03 is for informational purposes only and the information and the Trustee’s receipt of the foregoing shall not constitute
constructive notice of any information contained therein, or determinable from information contained therein including the Company’s compliance
with any of their covenants thereunder (as to which the Trustee is entitled to rely exclusively on an Officer’s Certificate).
Section 7.03 Trustee Not Responsible for Recitals
or Issuance or Securities .
(a) The recitals contained herein and in the Securities
shall be taken as the statements of the Company, and the Trustee assumes no responsibility for the correctness of the same.
(b) The Trustee makes no representations as to
the validity or sufficiency of this Indenture or of the Securities.
(c) The Trustee shall not be accountable for the
use or application by the Company of any of the Securities or of the proceeds of such Securities, or for the use or application of any
moneys paid over by the Trustee in accordance with any provision of this Indenture or established pursuant to Section 2.01, or for the
use or application of any moneys received by any paying agent other than the Trustee.
Section 7.04 May Hold Securities .
The Trustee or any paying agent or Security Registrar,
in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if it were
not Trustee, paying agent or Security Registrar.
Section 7.05 Moneys Held in Trust .
Subject to the provisions of Section 11.05, all
moneys received by the Trustee shall, until used or applied as herein provided, be held in trust for the purposes for which they were
received, but need not be segregated from other funds except to the extent required by law. The Trustee shall be under no liability for
interest on any moneys received by it hereunder except such as it may agree with the Company to pay thereon.
Section 7.06 Compensation and Reimbursement
..
(a) The Company covenants and agrees to pay to
the Trustee, and the Trustee shall be entitled to, such reasonable compensation (which shall not be limited by any provision of law in
regard to the compensation of a trustee of an express trust) as the Company and the Trustee may from time to time agree in writing, for
all services rendered by it in the execution of the trusts hereby created and in the exercise and performance of any of the powers and
duties hereunder of the Trustee, and, except as otherwise expressly provided herein, the Company will pay or reimburse the Trustee upon
its request for all reasonable expenses, disbursements and advances incurred or made by the Trustee in accordance with any of the provisions
of this Indenture (including the reasonable compensation and the expenses and disbursements of its counsel and of all Persons not regularly
in its employ), except any such expense, disbursement or advance as may arise from its negligence or bad faith and except as the Company
and Trustee may from time to time agree in writing. The Company also covenants to indemnify the Trustee (and its officers, agents, directors
and employees) for, and to hold it harmless against, any loss, liability or expense incurred without negligence or bad faith on the part
of the Trustee and arising out of or in connection with the acceptance or administration of this trust, including the reasonable costs
and expenses of defending itself against any claim of liability in the premises.
(b) The obligations of the Company under this
Section to compensate and indemnify the Trustee and to pay or reimburse the Trustee for reasonable expenses, disbursements and advances
shall constitute indebtedness of the Company to which the Securities are subordinated. Such additional indebtedness shall be secured by
a lien prior to that of the Securities upon all property and funds held or collected by the Trustee as such, except funds held in trust
for the benefit of the holders of particular Securities.
Section 7.07 Reliance on Officer’s Certificate
..
Except as otherwise provided in Section 7.01,
whenever in the administration of the provisions of this Indenture the Trustee shall deem it reasonably necessary or desirable that a
matter be proved or established prior to taking or suffering or omitting to take any action hereunder, such matter (unless other evidence
in respect thereof be herein specifically prescribed) may, in the absence of negligence or bad faith on the part of the Trustee, be deemed
to be conclusively proved and established by an Officer’s Certificate delivered to the Trustee and such certificate, in the absence of
negligence or bad faith on the part of the Trustee, shall be full warrant to the Trustee for any action taken, suffered or omitted to
be taken by it under the provisions of this Indenture upon the faith thereof.
Section 7.08 Disqualification; Conflicting
Interests .
If the Trustee has or shall acquire any “conflicting
interest” within the meaning of Section 310(b) of the Trust Indenture Act, the Trustee and the Company shall in all respects comply
with the provisions of Section 310(b) of the Trust Indenture Act.
Section 7.09 Corporate Trustee Required; Eligibility
..
There shall at all times be a Trustee with respect
to the Securities issued hereunder which shall at all times be a corporation organized and doing business under the laws of the United
States of America or any state or territory thereof or of the District of Columbia, or a corporation or other Person permitted to act
as trustee by the Securities and Exchange Commission, authorized under such laws to exercise corporate trust powers, having a combined
capital and surplus of at least fifty million U.S. dollars ($50,000,000), and subject to supervision or examination by federal, state,
territorial, or District of Columbia authority.
If such corporation or other
Person publishes reports of condition at least annually, pursuant to law or to the requirements of the aforesaid supervising or examining
authority, then for the purposes of this Section, the combined capital and surplus of such corporation or other Person shall be deemed
to be its combined capital and surplus as set forth in its most recent report of condition so published. The Company may not, nor may
any Person directly or indirectly controlling, controlled by, or under common control with the Company, serve as Trustee. In case at
any time the Trustee shall cease to be eligible in accordance with the provisions of this Section, the Trustee shall resign immediately
in the manner and with the effect specified in Section 7.10.
Section 7.10 Resignation and Removal; Appointment
of Successor .
(a) The Trustee or any successor hereafter appointed
may at any time resign with respect to the Securities of one or more series by giving written notice thereof to the Company and by transmitting
notice of resignation by mail, first class postage prepaid, to the Securityholders of such series, as their names and addresses appear
upon the Security Register. Upon receiving such notice of resignation, the Company shall promptly appoint a successor trustee with respect
to Securities of such series by written instrument, in duplicate, executed by order of the Board of Directors, one copy of which instrument
shall be delivered to the resigning Trustee and one copy to the successor trustee. If no successor trustee shall have been so appointed
and have accepted appointment within 30 days after the mailing of such notice of resignation, the resigning Trustee may petition any court
of competent jurisdiction for the appointment of a successor trustee with respect to Securities of such series, or any Securityholder
of that series who has been a bona fide holder of a Security or Securities for at least six months may on behalf of himself and all others
similarly situated, petition any such court for the appointment of a successor trustee. Such court may thereupon after such notice, if
any, as it may deem proper and prescribe, appoint a successor trustee.
(b) In case at any time any one of the following
shall occur:
(i) the Trustee shall fail to comply with the provisions
of Section 7.08 after written request therefor by the Company or by any Securityholder who has been a bona fide holder of a Security or
Securities for at least six months; or
(ii) the Trustee shall cease to be eligible in accordance
with the provisions of Section 7.09 and shall fail to resign after written request therefor by the Company or by any such Securityholder;
or
(iii) the Trustee shall become incapable of acting,
or shall be adjudged a bankrupt or insolvent, or commence a voluntary bankruptcy proceeding, or a receiver of the Trustee or of its property
shall be appointed or consented to, or any public officer shall take charge or control of the Trustee or of its property or affairs for
the purpose of rehabilitation, conservation or liquidation;
then, in any such case, the Company may remove
the Trustee with respect to all Securities and appoint a successor trustee by written instrument, in duplicate, executed by order of the
Board of Directors, one copy of which instrument shall be delivered to the Trustee so removed and one copy to the successor trustee, or
any Securityholder who has been a bona fide holder of a Security or Securities for at least six months may, on behalf of that holder and
all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor
trustee. Such court may thereupon after such notice, if any, as it may deem proper and prescribe, remove the Trustee and appoint a successor
trustee.
(c) The holders of a majority in aggregate principal
amount of the Securities of any series at the time Outstanding may at any time remove the Trustee with respect to such series by so notifying
the Trustee and the Company and may appoint a successor Trustee for such series with the consent of the Company.
(d) Any resignation or removal of the Trustee
and appointment of a successor trustee with respect to the Securities of a series pursuant to any of the provisions of this Section shall
become effective upon acceptance of appointment by the successor trustee as provided in Section 7.11.
(e) Any successor trustee appointed pursuant to
this Section may be appointed with respect to the Securities of one or more series or all of such series, and at any time there shall
be only one Trustee with respect to the Securities of any particular series.
Section 7.11 Acceptance of Appointment By Successor
..
(a) In case of the appointment hereunder of a
successor trustee with respect to all Securities, every such successor trustee so appointed shall execute, acknowledge and deliver to
the Company and to the retiring Trustee an instrument accepting such appointment, and thereupon the resignation or removal of the retiring
Trustee shall become effective and such successor trustee, without any further act, deed or conveyance, shall become vested with all the
rights, powers, trusts and duties of the retiring Trustee; but, on the request of the Company or the successor trustee, such retiring
Trustee shall, upon payment of its charges, execute and deliver an instrument transferring to such successor trustee all the rights, powers,
and trusts of the retiring Trustee and shall duly assign, transfer and deliver to such successor trustee all property and money held by
such retiring Trustee hereunder.
(b) In case of the appointment hereunder of a
successor trustee with respect to the Securities of one or more (but not all) series, the Company, the retiring Trustee and each successor
trustee with respect to the Securities of one or more series shall execute and deliver an indenture supplemental hereto wherein each successor
trustee shall accept such appointment and which (i) shall contain such provisions as shall be necessary or desirable to transfer and confirm
to, and to vest in, each successor trustee all the rights, powers, trusts and duties of the retiring Trustee with respect to the Securities
of that or those series to which the appointment of such successor trustee relates, (ii) shall contain such provisions as shall be deemed
necessary or desirable to confirm that all the rights, powers, trusts and duties of the retiring Trustee with respect to the Securities
of that or those series as to which the retiring Trustee is not retiring shall continue to be vested in the retiring Trustee, and (iii)
shall add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration of
the trusts hereunder by more than one Trustee, it being understood that nothing herein or in such supplemental indenture shall constitute
such Trustees co-trustees of the same trust, that each such Trustee shall be trustee of a trust or trusts hereunder separate and apart
from any trust or trusts hereunder administered by any other such Trustee and that no Trustee shall be responsible for any act or failure
to act on the part of any other Trustee hereunder; and upon the execution and delivery of such supplemental indenture the resignation
or removal of the retiring Trustee shall become effective to the extent provided therein, such retiring Trustee shall with respect to
the Securities of that or those series to which the appointment of such successor trustee relates have no further responsibility for the
exercise of rights and powers or for the performance of the duties and obligations vested in the Trustee under this Indenture, and each
such successor trustee, without any further act, deed or conveyance, shall become vested with all the rights, powers, trusts and duties
of the retiring Trustee with respect to the Securities of that or those series to which the appointment of such successor trustee relates;
but, on request of the Company or any successor trustee, such retiring Trustee shall duly assign, transfer and deliver to such successor
trustee, to the extent contemplated by such supplemental indenture, the property and money held by such retiring Trustee hereunder with
respect to the Securities of that or those series to which the appointment of such successor trustee relates.
(c) Upon request of any such successor trustee,
the Company shall execute any and all instruments for more fully and certainly vesting in and confirming to such successor trustee all
such rights, powers and trusts referred to in paragraph (a) or (b) of this Section, as the case may be.
(d) No successor trustee shall accept its appointment
unless at the time of such acceptance such successor trustee shall be qualified and eligible under this Article.
(e) Upon acceptance of appointment by a successor
trustee as provided in this Section, the Company shall transmit notice of the succession of such trustee hereunder by mail, first class
postage prepaid, to the Securityholders, as their names and addresses appear upon the Security Register. If the Company fails to transmit
such notice within ten days after acceptance of appointment by the successor trustee, the successor trustee shall cause such notice to
be transmitted at the expense of the Company.
Section 7.12 Merger, Conversion, Consolidation
or Succession to Business .
Any corporation into which the Trustee may be
merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to
which the Trustee shall be a party, or any corporation succeeding to the corporate trust business of the Trustee, including the administration
of the trust created by this Indenture, shall be the successor of the Trustee hereunder, provided that such corporation shall be qualified
under the provisions of Section 7.08 and eligible under the provisions of Section 7.09, without the execution or filing of any paper or
any further act on the part of any of the parties hereto, anything herein to the contrary notwithstanding. In case any Securities shall
have been authenticated, but not delivered, by the Trustee then in office, any successor by merger, conversion or consolidation to such
authenticating Trustee may adopt such authentication and deliver the Securities so authenticated with the same effect as if such successor
Trustee had itself authenticated such Securities.
Section 7.13 Preferential Collection of Claims
Against the Company .
The Trustee shall comply with Section 311(a) of
the Trust Indenture Act, excluding any creditor relationship described in Section 311(b) of the Trust Indenture Act. A Trustee who has
resigned or been removed shall be subject to Section 311(a) of the Trust Indenture Act to the extent included therein.
Section 7.14 Notice of Default
If any Default or any Event of Default
occurs and is continuing and if such Default or Event of Default is known to a Responsible Officer of the Trustee, the Trustee shall
mail to each Securityholder in the manner and to the extent provided in Section 313(c) of the Trust Indenture Act notice of the
Default or Event of Default within the earlier of 90 days after it occurs and 30 days after it is known to a Responsible Officer of
the Trustee or written notice of it is received by the Trustee, unless such Default or Event of Default has been cured; provided,
however, that, except in the case of a default in the payment of the principal of (or premium, if any) or interest on any Security,
the Trustee shall be protected in withholding such notice if and so long as the board of directors, the executive committee or a
trust committee of directors and/or Responsible Officers of the Trustee in good faith determine that the withholding of such notice
is in the interest of the Securityholders.
ARTICLE 8
CONCERNING THE SECURITYHOLDERS
Section 8.01 Evidence of Action by Securityholders
..
Whenever in this Indenture it is provided that
the holders of a majority or specified percentage in aggregate principal amount of the Securities of a particular series may take any
action (including the making of any demand or request, the giving of any notice, consent or waiver or the taking of any other action),
the fact that at the time of taking any such action the holders of such majority or specified percentage of that series have joined therein
may be evidenced by any instrument or any number of instruments of similar tenor executed by such holders of Securities of that series
in person or by agent or proxy appointed in writing.
If the Company shall solicit from the
Securityholders of any series any request, demand, authorization, direction, notice, consent, waiver or other action, the Company may,
at its option, as evidenced by an Officer’s Certificate, fix in advance a record date for such series for the determination of Securityholders
entitled to give such request, demand, authorization, direction, notice, consent, waiver or other action, but the Company shall have no
obligation to do so. If such a record date is fixed, such request, demand, authorization, direction, notice, consent, waiver or other
action may be given before or after the record date, but only the Securityholders of record at the close of business on the record date
shall be deemed to be Securityholders for the purposes of determining whether Securityholders of the requisite proportion of Outstanding
Securities of that series have authorized or agreed or consented to such request, demand, authorization, direction, notice, consent, waiver
or other action, and for that purpose the Outstanding Securities of that series shall be computed as of the record date; provided, however,
that no such authorization, agreement or consent by such Securityholders on the record date shall be deemed effective unless it shall
become effective pursuant to the provisions of this Indenture not later than six months after the record date.
Section 8.02 Proof of Execution by
Securityholders.
Subject to the provisions of Section 7.01, proof
of the execution of any instrument by a Securityholder (such proof will not require notarization) or his agent or proxy and proof of the
holding by any Person of any of the Securities shall be sufficient if made in the following manner:
(a) The fact and date of the execution by any
such Person of any instrument may be proved in any reasonable manner acceptable to the Trustee.
(b) The ownership of Securities shall be proved
by the Security Register of such Securities or by a certificate of the Security Registrar thereof.
The Trustee may require such additional proof of any matter referred
to in this Section as it shall deem necessary.
Section 8.03 Who May be Deemed Owners.
Prior to the due presentment
for registration of transfer of any Security, the Company, the Trustee, any paying agent and any Security Registrar may deem and treat
the Person in whose name such Security shall be registered upon the books of the Company as the absolute owner of such Security (whether
or not such Security shall be overdue and notwithstanding any notice of ownership or writing thereon made by anyone other than the Security
Registrar) for the purpose of receiving payment of or on account of the principal of, premium, if any, and (subject to Section 2.03)
interest on such Security and for all other purposes; and neither the Company nor the Trustee nor any paying agent nor any Security Registrar
shall be affected by any notice to the contrary.
Section 8.04 Certain Securities Owned
by Company Disregarded.
In determining whether the holders of the requisite
aggregate principal amount of Securities of a particular series have concurred in any direction, consent or waiver under this Indenture,
the Securities of that series that are owned by the Company or any other obligor on the Securities of that series or by any Person directly
or indirectly controlling or controlled by or under common control with the Company or any other obligor on the Securities of that series
shall be disregarded and deemed not to be Outstanding for the purpose of any such determination, except that for the purpose of determining
whether the Trustee shall be protected in relying on any such direction, consent or waiver, only Securities of such series that the Trustee
actually knows are so owned shall be so disregarded. The Securities so owned that have been pledged in good faith may be regarded as Outstanding
for the purposes of this Section, if the pledgee shall establish to the satisfaction of the Trustee the pledgee’s right so to act with
respect to such Securities and that the pledgee is not a Person directly or indirectly controlling or controlled by or under direct or
indirect common control with the Company or any such other obligor. In case of a dispute as to such right, any decision by the Trustee
taken upon the advice of counsel shall be full protection to the Trustee.
Section 8.05 Actions Binding on Future
Securityholders.
At any time prior to (but not after) the evidencing
to the Trustee, as provided in Section 8.01, of the taking of any action by the holders of the majority or percentage in aggregate principal
amount of the Securities of a particular series specified in this Indenture in connection with such action, any holder of a Security of
that series that is shown by the evidence to be included in the Securities the holders of which have consented to such action may, by
filing written notice with the Trustee, and upon proof of holding as provided in Section 8.02, revoke such action so far as concerns such
Security. Except as aforesaid any such action taken by the holder of any Security shall be conclusive and binding upon such holder and
upon all future holders and owners of such Security, and of any Security issued in exchange therefor, on registration of transfer thereof
or in place thereof, irrespective of whether or not any notation in regard thereto is made upon such Security. Any action taken by the
holders of the majority or percentage in aggregate principal amount of the Securities of a particular series specified in this Indenture
in connection with such action shall be conclusively binding upon the Company, the Trustee and the holders of all the Securities of that
series.
ARTICLE 9
SUPPLEMENTAL INDENTURES
Section 9.01 Supplemental Indentures Without
the Consent of Securityholders .
In addition to any supplemental indenture otherwise
authorized by this Indenture, the Company and the Trustee may from time to time and at any time enter into an indenture or indentures
supplemental hereto (which shall conform to the provisions of the Trust Indenture Act as then in effect), without the consent of the Securityholders,
for one or more of the following purposes:
(a) to cure any ambiguity, defect, or inconsistency
herein or in the Securities of any series;
(b) to comply with Article Ten;
(c) to provide for uncertificated Securities in
addition to or in place of certificated Securities;
(d) to add to the covenants, restrictions, conditions
or provisions relating to the Company for the benefit of the holders of all or any series of Securities (and if such covenants, restrictions,
conditions or provisions are to be for the benefit of less than all series of Securities, stating that such covenants, restrictions, conditions
or provisions are expressly being included solely for the benefit of such series), to make the occurrence, or the occurrence and the continuance,
of a default in any such additional covenants, restrictions, conditions or provisions an Event of Default, or to surrender any right or
power herein conferred upon the Company;
(e) to add to, delete from, or revise the conditions,
limitations, and restrictions on the authorized amount, terms, or purposes of issue, authentication, and delivery of Securities, as herein
set forth;
(f) to make any change that does not adversely
affect the rights of any Securityholder in any material respect;
(g) to provide for the issuance of and establish
the form and terms and conditions of the Securities of any series as provided in Section 2.01, to establish the form of any certifications
required to be furnished pursuant to the terms of this Indenture or any series of Securities, or to add to the rights of the holders of
any series of Securities;
(h) to evidence and provide for the acceptance
of appointment hereunder by a successor trustee; or
(i) to comply with any requirements of the Securities
and Exchange Commission or any successor in connection with the qualification of this Indenture under the Trust Indenture Act.
The Trustee is hereby authorized to join with
the Company in the execution of any such supplemental indenture, and to make any further appropriate agreements and stipulations that
may be therein contained, but the Trustee shall not be obligated to enter into any such supplemental indenture that affects the Trustee’s
own rights, duties or immunities under this Indenture or otherwise.
Any supplemental indenture authorized by the provisions
of this Section may be executed by the Company and the Trustee without the consent of the holders of any of the Securities at the time
Outstanding, notwithstanding any of the provisions of Section 9.02.
Section 9.02 Supplemental Indentures With Consent of
Securityholders.
With the consent (evidenced as provided in Section
8.01) of the holders of not less than a majority in aggregate principal amount of the Securities of each series affected by such supplemental
indenture or indentures at the time Outstanding, the Company, when authorized by a Board Resolution, and the Trustee may from time to
time and at any time enter into an indenture or indentures supplemental hereto (which shall conform to the provisions of the Trust Indenture
Act as then in effect) for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of this
Indenture or of any supplemental indenture or of modifying in any manner not covered by Section 9.01 the rights of the holders of the
Securities of such series under this Indenture; provided, however, that no such supplemental indenture shall, without the consent of the
holders of each Security then Outstanding and affected thereby, (a) extend the fixed maturity of any Securities of any series, or reduce
the principal amount thereof, or reduce the rate or extend the time of payment of interest thereon, or reduce any premium payable upon
the redemption thereof or (b) reduce the aforesaid percentage of Securities, the holders of which are required to consent to any such
supplemental indenture.
It shall not be necessary for the consent of the
Securityholders of any series affected thereby under this Section to approve the particular form of any proposed supplemental indenture,
but it shall be sufficient if such consent shall approve the substance thereof.
Section 9.03 Effect of Supplemental Indentures.
Upon the execution of any supplemental indenture
pursuant to the provisions of this Article or of Section 10.01, this Indenture shall, with respect to such series, be and be deemed to
be modified and amended in accordance therewith and the respective rights, limitations of rights, obligations, duties and immunities under
this Indenture of the Trustee, the Company and the holders of Securities of the series affected thereby shall thereafter be determined,
exercised and enforced hereunder subject in all respects to such modifications and amendments, and all the terms and conditions of any
such supplemental indenture shall be and be deemed to be part of the terms and conditions of this Indenture for any and all purposes.
Section 9.04 Securities Affected by Supplemental Indentures.
Securities of any series affected by a supplemental
indenture, authenticated and delivered after the execution of such supplemental indenture pursuant to the provisions of this Article or
of Section 10.01, may bear a notation in form approved by the Company, provided such form meets the requirements of any securities exchange
upon which such series may be listed, as to any matter provided for in such supplemental indenture. If the Company shall so determine,
new Securities of that series so modified as to conform, in the opinion of the Board of Directors, to any modification of this Indenture
contained in any such supplemental indenture may be prepared by the Company, authenticated by the Trustee and delivered in exchange for
the Securities of that series then Outstanding.
Section 9.05 Execution of Supplemental Indentures.
Upon the request of the
Company, accompanied by its Board Resolutions authorizing the execution of any such supplemental indenture, and upon the filing with
the Trustee of evidence of the consent of Securityholders required to consent thereto as aforesaid, the Trustee shall join with the
Company in the execution of such supplemental indenture unless such supplemental indenture affects the Trustee’s own rights, duties
or immunities under this Indenture or otherwise, in which case the Trustee may in its discretion but shall not be obligated to enter
into such supplemental indenture. The Trustee, subject to the provisions of Section 7.01, may receive an Officer’s Certificate or,
if requested, an Opinion of Counsel as conclusive evidence that any supplemental indenture executed pursuant to this Article is
authorized or permitted by, and conforms to, the terms of this Article and that it is proper for the Trustee under the provisions of
this Article to join in the execution thereof; provided, however, that such Officer’s Certificate or Opinion of Counsel need not be
provided in connection with the execution of a supplemental indenture that establishes the terms of a series of Securities pursuant
to Section 2.01 hereof.
Promptly after the execution by the Company and
the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Trustee shall transmit by mail, first class
postage prepaid, a notice, setting forth in general terms the substance of such supplemental indenture, to the Securityholders of all
series affected thereby as their names and addresses appear upon the Security Register. Any failure of the Trustee to mail such notice,
or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture.
ARTICLE 10
SUCCESSOR ENTITY
Section 10.01 Company May Consolidate, Etc
..
Except as provided pursuant to Section 2.01 pursuant
to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental to this Indenture,
nothing contained in this Indenture shall prevent any consolidation or merger of the Company with or into any other Person (whether or
not affiliated with the Company) or successive consolidations or mergers in which the Company or its successor or successors shall be
a party or parties, or shall prevent any sale, conveyance, transfer or other disposition of the property of the Company or its successor
or successors as an entirety, or substantially as an entirety, to any other corporation (whether or not affiliated with the Company or
its successor or successors) authorized to acquire and operate the same; provided, however, (a) the Company hereby covenants and agrees
that, upon any such consolidation or merger (in each case, if the Company is not the survivor of such transaction), sale, conveyance,
transfer or other disposition, the due and punctual payment of the principal of (premium, if any) and interest on all of the Securities
of all series in accordance with the terms of each series, according to their tenor, and the due and punctual performance and observance
of all the covenants and conditions of this Indenture with respect to each series or established with respect to such series pursuant
to Section 2.01 to be kept or performed by the Company shall be expressly assumed, by supplemental indenture (which shall conform to the
provisions of the Trust Indenture Act, as then in effect) reasonably satisfactory in form to the Trustee executed and delivered to the
Trustee by the entity formed by such consolidation, or into which the Company shall have been merged, or by the entity which shall have
acquired such property and (b) in the event that the Securities of any series then Outstanding are convertible into or exchangeable for
shares of common stock or other securities of the Company, such entity shall, by such supplemental indenture, make provision so that the
Securityholders of Securities of that series shall thereafter be entitled to receive upon conversion or exchange of such Securities the
number of securities or property to which a holder of the number of shares of common stock or other securities of the Company deliverable
upon conversion or exchange of those Securities would have been entitled had such conversion or exchange occurred immediately prior to
such consolidation, merger, sale, conveyance, transfer or other disposition.
Section 10.02 Successor Entity Substituted.
(a) In case of any such consolidation, merger,
sale, conveyance, transfer or other disposition and upon the assumption by the successor entity by supplemental indenture, executed and
delivered to the Trustee and satisfactory in form to the Trustee, of the obligations set forth under Section 10.01 on all of the Securities
of all series Outstanding, such successor entity shall succeed to and be substituted for the Company with the same effect as if it had
been named as the Company herein, and thereupon the predecessor corporation shall be relieved of all obligations and covenants under this
Indenture and the Securities.
(b) In case of any such consolidation, merger,
sale, conveyance, transfer or other disposition, such changes in phraseology and form (but not in substance) may be made in the Securities
thereafter to be issued as may be appropriate.
(c) Nothing contained in this Article shall require
any action by the Company in the case of a consolidation or merger of any Person into the Company where the Company is the survivor of
such transaction, or the acquisition by the Company, by purchase or otherwise, of all or any part of the property of any other Person
(whether or not affiliated with the Company).
Section 10.03 Evidence of Consolidation,
Etc. to Trustee.
The Trustee, subject to the provisions of Section
7.01, may receive an Officer’s Certificate and, if requested, an Opinion of Counsel as conclusive evidence that any such consolidation,
merger, sale, conveyance, transfer or other disposition, and any such assumption, comply with the provisions of this Article.
ARTICLE 11
SATISFACTION AND DISCHARGE
Section 11.01 Satisfaction and Discharge of
Indenture .
If at any time: (a) the Company shall have delivered
to the Trustee for cancellation all Securities of a series theretofore authenticated and not delivered to the Trustee for cancellation
(other than any Securities that shall have been destroyed, lost or stolen and that shall have been replaced or paid as provided in Section
2.07 and Securities for whose payment money or Governmental Obligations have theretofore been deposited in trust or segregated and held
in trust by the Company and thereupon repaid to the Company or discharged from such trust, as provided in Section 11.05); or (b) all such
Securities of a particular series not theretofore delivered to the Trustee for cancellation shall have become due and payable, or are
by their terms to become due and payable within one year or are to be called for redemption within one year under arrangements satisfactory
to the Trustee for the giving of notice of redemption, and the Company shall deposit or cause to be deposited with the Trustee as trust
funds the entire amount in moneys or Governmental Obligations or a combination thereof, sufficient in the opinion of a nationally recognized
firm of independent public accountants expressed in a written certification thereof delivered to the Trustee, to pay at maturity or upon
redemption all Securities of that series not theretofore delivered to the Trustee for cancellation, including principal (and premium,
if any) and interest due or to become due to such date of maturity or date fixed for redemption, as the case may be, and if the Company
shall also pay or cause to be paid all other sums payable hereunder with respect to such series by the Company then this Indenture shall
thereupon cease to be of further effect with respect to such series except for the provisions of Sections 2.03, 2.05, 2.07, 4.01, 4.02,
4.03 and 7.10, that shall survive until the date of maturity or redemption date, as the case may be, and Sections 7.06 and 11.05, that
shall survive to such date and thereafter, and the Trustee, on demand of the Company and at the cost and expense of the Company shall
execute proper instruments acknowledging satisfaction of and discharging this Indenture with respect to such series.
Section 11.02 Discharge of Obligations.
If at any time all such Securities of a particular
series not heretofore delivered to the Trustee for cancellation or that have not become due and payable as described in Section 11.01
shall have been paid by the Company by depositing irrevocably with the Trustee as trust funds moneys or an amount of Governmental Obligations
sufficient to pay at maturity or upon redemption all such Securities of that series not theretofore delivered to the Trustee for cancellation,
including principal (and premium, if any) and interest due or to become due to such date of maturity or date fixed for redemption, as
the case may be, and if the Company shall also pay or cause to be paid all other sums payable hereunder by the Company with respect to
such series, then after the date such moneys or Governmental Obligations, as the case may be, are deposited with the Trustee the obligations
of the Company under this Indenture with respect to such series shall cease to be of further effect except for the provisions of Sections
2.03, 2.05, 2.07, 4,01, 4.02, 4,03, 7.06, 7.10 and 11.05 hereof that shall survive until such Securities shall mature and be paid.
Thereafter, Sections 7.06 and 11.05 shall survive.
Section 11.03 Deposited Moneys to
be Held in Trust.
All moneys or Governmental Obligations deposited
with the Trustee pursuant to Sections 11.01 or 11.02 shall be held in trust and shall be available for payment as due, either directly
or through any paying agent (including the Company acting as its own paying agent), to the holders of the particular series of Securities
for the payment or redemption of which such moneys or Governmental Obligations have been deposited with the Trustee.
Section 11.04 Payment of Moneys Held
by Paying Agents.
In connection with the satisfaction and
discharge of this Indenture all moneys or Governmental Obligations then held by any paying agent under the provisions of this
Indenture shall, upon demand of the Company, be paid to the Trustee and thereupon such paying agent shall be released from all
further liability with respect to such moneys or Governmental Obligations.
Section 11.05 Repayment to Company.
Any moneys or Governmental Obligations deposited
with any paying agent or the Trustee, or then held by the Company, in trust for payment of principal of or premium, if any, or interest
on the Securities of a particular series that are not applied but remain unclaimed by the holders of such Securities for at least two
years after the date upon which the principal of (and premium, if any) or interest on such Securities shall have respectively become due
and payable, or such other shorter period set forth in applicable escheat or abandoned or unclaimed property law, shall be repaid to the
Company on May 31 of each year or upon the Company’s request or (if then held by the Company) shall be discharged from such trust; and
thereupon the paying agent and the Trustee shall be released from all further liability with respect to such moneys or Governmental Obligations,
and the holder of any of the Securities entitled to receive such payment shall thereafter, as a general creditor, look only to the Company
for the payment thereof.
ARTICLE 12
IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS
AND DIRECTORS
Section 12.01 No Recourse .
No recourse under or upon any obligation, covenant
or agreement of this Indenture, or of any Security, or for any claim based thereon or otherwise in respect thereof, shall be had against
any incorporator, stockholder, officer or director, past, present or future as such, of the Company or of any predecessor or successor
corporation, either directly or through the Company or any such predecessor or successor corporation, whether by virtue of any constitution,
statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that this Indenture
and the obligations issued hereunder are solely corporate obligations, and that no such personal liability whatever shall attach to, or
is or shall be incurred by, the incorporators, stockholders, officers or directors as such, of the Company or of any predecessor or successor
corporation, or any of them, because of the creation of the indebtedness hereby authorized, or under or by reason of the obligations,
covenants or agreements contained in this Indenture or in any of the Securities or implied therefrom; and that any and all such personal
liability of every name and nature, either at common law or in equity or by constitution or statute, of, and any and all such rights and
claims against, every such incorporator, stockholder, officer or director as such, because of the creation of the indebtedness hereby
authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture or in any of the Securities
or implied therefrom, are hereby expressly waived and released as a condition of, and as a consideration for, the execution of this Indenture
and the issuance of such Securities.
ARTICLE 13
MISCELLANEOUS PROVISIONS
Section 13.01 Effect on Successors and Assigns
..
All the covenants, stipulations, promises and
agreements in this Indenture made by or on behalf of the Company shall bind its successors and assigns, whether so expressed or not.
Section 13.02 Actions by Successor.
Any act or proceeding by any provision of this
Indenture authorized or required to be done or performed by any board, committee or officer of the Company shall and may be done and performed
with like force and effect by the corresponding board, committee or officer of any corporation that shall at the time be the lawful successor
of the Company.
Section 13.03 Surrender of Company
Powers.
The Company by instrument in writing executed
by authority of its Board of Directors and delivered to the Trustee may surrender any of the powers reserved to the Company, and thereupon
such power so surrendered shall terminate both as to the Company and as to any successor corporation.
Section 13.04 Notices.
Except as otherwise expressly provided herein,
any notice, request or demand that by any provision of this Indenture is required or permitted to be given, made or served by the Trustee
or by the holders of Securities or by any other Person pursuant to this Indenture to or on the Company may be given or served by being
deposited in first class mail, postage prepaid, addressed (until another address is filed in writing by the Company with the Trustee),
as follows: . Any notice, election, request or demand by the Company or any Securityholder or by any other Person pursuant to this Indenture
to or upon the Trustee shall be deemed to have been sufficiently given or made, for all purposes, if given or made in writing at the Corporate
Trust Office of the Trustee.
Section 13.05 Governing Law.
This Indenture and each Security shall be deemed
to be a contract made under the internal laws of the State of New York, and for all purposes shall be construed in accordance with the
laws of said State, except to the extent that the Trust Indenture Act is applicable.
Section 13.06 Treatment of Securities
as Debt.
It is intended that the Securities will be treated
as indebtedness and not as equity for federal income tax purposes. The provisions of this Indenture shall be interpreted to further this
intention.
Section 13.07 Certificates and Opinions
as to Conditions Precedent.
(a) Upon any application or demand by the Company
to the Trustee to take any action under any of the provisions of this Indenture, the Company shall furnish to the Trustee an Officer’s
Certificate stating that all conditions precedent provided for in this Indenture (other than the certificate to be delivered pursuant
to Section 13.12) relating to the proposed action have been complied with and, if requested, an Opinion of Counsel stating that in the
opinion of such counsel all such conditions precedent have been complied with, except that in the case of any such application or demand
as to which the furnishing of such documents is specifically required by any provision of this Indenture relating to such particular application
or demand, no additional certificate or opinion need be furnished.
(b) Each certificate or opinion provided for in
this Indenture and delivered to the Trustee with respect to compliance with a condition or covenant in this Indenture shall include (i)
a statement that the Person making such certificate or opinion has read such covenant or condition; (ii) a brief statement as to the nature
and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based;
(iii) a statement that, in the opinion of such Person, he has made such examination or investigation as is reasonably necessary to enable
him to express an informed opinion as to whether or not such covenant or condition has been complied with; and (iv) a statement as to
whether or not, in the opinion of such Person, such condition or covenant has been complied with.
Section 13.08 Payments on Business
Days.
Except as provided pursuant to Section 2.01 pursuant
to a Board Resolution, and set forth in an Officer’s Certificate, or established in one or more indentures supplemental to this Indenture,
in any case where the date of maturity of interest or principal of any Security or the date of redemption of any Security shall not be
a Business Day, then payment of interest or principal (and premium, if any) may be made on the next succeeding Business Day with the same
force and effect as if made on the nominal date of maturity or redemption, and no interest shall accrue for the period after such nominal
date.
Section 13.09 Conflict with Trust
Indenture Act.
If and to the extent that any provision of this
Indenture limits, qualifies or conflicts with the duties imposed by Sections 310 to 317, inclusive, of the Trust Indenture Act, such imposed
duties shall control.
Section 13.10 Counterparts.
This Indenture may be executed in any number of
counterparts, each of which shall be an original, but such counterparts shall together constitute but one and the same instrument.
Section 13.11 Separability.
In case any one or more of the provisions contained
in this Indenture or in the Securities of any series shall for any reason be held to be invalid, illegal or unenforceable in any respect,
such invalidity, illegality or unenforceability shall not affect any other provisions of this Indenture or of such Securities, but this
Indenture and such Securities shall be construed as if such invalid or illegal or unenforceable provision had never been contained herein
or therein.
Section 13.12 Compliance Certificates.
The Company shall deliver to the Trustee, within
120 days after the end of each fiscal year during which any Securities of any series were outstanding, an officer’s certificate stating
whether or not the signers know of any Default or Event of Default that occurred during such fiscal year. Such certificate shall contain
a certification from the principal executive officer, principal financial officer or principal accounting officer of the Company that
a review has been conducted of the activities of the Company and the Company’s performance under this Indenture and that the Company has
complied with all conditions and covenants under this Indenture. For purposes of this Section 13.12, such compliance shall be determined
without regard to any period of grace or requirement of notice provided under this Indenture. If the officer of the Company signing such
certificate has knowledge of such a Default or Event of Default, the certificate shall describe any such Default or Event of Default and
its status.
ARTICLE 14
SUBORDINATION OF SECURITIES
Section 14.01 Subordination Terms .
The payment by the Company
of the principal of, premium, if any, and interest on any series of Securities issued hereunder shall be subordinated to the extent set
forth in an indenture supplemental hereto relating to such series.
IN WITNESS WHEREOF , the parties
hereto have caused this Indenture to be duly executed all as of the day and year first above written.
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UNICYCIVE THERAPEUTICS, INC. |
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[ TRUSTEE ], as Trustee |
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-31-
Exhibit 5.1
November 13, 2024
VIA ELECTRONIC MAIL
Unicycive Therapeutics, Inc.
4300 El Camino Real, Suite 210
Los Altos, CA 94022
Re: |
Registration Statement on Form S-3 |
Ladies and Gentlemen:
We have acted as special counsel to Unicycive
Therapeutics, Inc., a Delaware corporation (the “Company”), in connection with the shelf Registration Statement on
Form S-3 (as amended or supplemented, the “Registration Statement”), filed by the Company on November 13, 2024 with
the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended (the “Securities
Act”). The Registration Statement relates to the proposed issuance and sale from time to time pursuant to Rule 415 under the
Securities Act, as set forth in the Registration Statement, the prospectus contained therein (the “Base Prospectus”)
and one or more supplements to the Base Prospectus (each, a “Prospectus Supplement”) and any free-writing prospectus(es)
of up to $100,000,000 aggregate offering proceeds, of the following securities of the Company (collectively, the “Securities”):
| ● | shares of common stock, par
value $0.001 per share, of the Company (the “Common Stock”); |
| ● | shares of preferred stock,
par value $0.001 par value, of the Company, in one or more series or classes (the “Preferred Stock”); |
| ● | debt securities, in one or
more series (the “Debt Securities”), which may be issued pursuant to an indenture to be dated on or about the date
of the first issuance of Debt Securities thereunder, but which may not be guaranteed by any affiliates of the Company or any other person,
by and between a trustee to be selected by the Company (the “Trustee”) and the Company, in the form filed as Exhibit
4.3 or Exhibit 4.4 to the Registration Statement (the “Indenture”); |
| ● | warrants to purchase Common
Stock, Preferred Stock or Debt Securities (the “Warrants”), which may be issued under warrant agreements (each, a
“Warrant Agreement”), to be dated on or about the date of the first issuance of the applicable Warrants thereunder,
by and between the Company and a warrant agent to be selected by the Company (the “Warrant Agent”); and |
| ● | units consisting of Common
Stock, Preferred Stock, Debt Securities, or Warrants (the “Units”), which may be issued under unit agreements (each,
a “Unit Agreement”), to be dated on or about the date of the first issuance of the applicable Units thereunder, by
and between the Company and the other parties thereto (the “Unit Parties”). |
We are also
acting as counsel for the Company in connection with the sales agreement prospectus included in the Registration Statement (the “Sales
Agreement Prospectus”) relating to the issuance and sale of shares of Common Stock having an aggregate offering price of up to $50,000,000
(the “Sales Agreement Shares”) under a Sales Agreement, dated November 12, 2024, between the Company and Guggenheim
Securities, LLC (the “Sales Agreement”).
We are delivering this opinion pursuant to the
requirements of Item 601(b)(5) of Regulation S-K under the Securities Act.
In connection with this opinion, we have examined
and relied upon originals, or copies certified to our satisfaction, of such records, documents, certificates, opinions, memoranda and
other instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. As to certain factual
matters, we have relied upon certificates of officers of the Company and have not independently sought to verify such matters.
In rendering this opinion, we have assumed (i)
the genuineness and authenticity of all signatures on original documents; (ii) the authenticity of all documents submitted to us as originals;
(iii) the conformity to originals of all documents submitted to us as copies; (iv) the accuracy, completeness and authenticity of certificates
of public officials; (v) the due authorization, execution and delivery of all documents where authorization, execution and delivery are
prerequisites to the effectiveness of such documents; (vi) that the Registration Statement and any required post-effective amendment thereto
have all become effective under the Securities Act and the Base Prospectus, other than for the Sales Agreement Shares, any and all Prospectus
Supplement(s) required by applicable laws and any and all free-writing prospectus(es) related to the offer and sale of the Securities
have been delivered and filed as required by such laws; (vii) that the issuance and sale of the Securities do not violate any applicable
law, are in conformity with the Company’s then operative Certificate of Incorporation (as defined below) and bylaws, do not result
in a default under or breach of any agreement or instrument binding upon the Company and comply with any applicable requirement or restriction
imposed by any court or governmental body having jurisdiction over the Company or its properties or assets; (viii) a prospectus supplement
will have been prepared and filed with the Commission describing the Securities offered thereby; (ix) other than for the Sales Agreement
Shares, a definitive purchase, underwriting or similar agreement with respect to any Securities offered will have been duly authorized
and validly executed and delivered by the Company and the other parties thereto, as applicable; and (x) if the holders of the Debt Securities
are granted rights to inspect corporate books and records and to vote in the election of directors or any matters on which stockholders
of the Company may vote, such rights will be set forth in the Certificate of Incorporation or the Certificate of Incorporation grants
to the Company’s Board of Directors the power to confer such voting or inspection rights and the Company’s Board of Directors
will have conferred such rights.
With respect to our opinion as to the Common Stock
or other Securities convertible into, exercisable for, or including Common Stock, we have been advised by the Company and for purposes
of this opinion we have assumed that, at the time of issuance and sale, a sufficient number of shares of Common Stock are authorized and
available for issuance and that the consideration for the issuance and sale of the Common Stock (or for Preferred Stock or Debt Securities
convertible into Common Stock, or for Warrants exercisable for Common Stock, or Units consisting of or including Common Stock) is in an
amount that is not less than the par value of the Common Stock. With respect to our opinion as to the Preferred Stock or other Securities
convertible into, exercisable for, or including Preferred Stock, we have assumed that, (a) at the time of issuance and sale, a sufficient
number of shares of Preferred Stock are authorized, designated and available for issuance and that the consideration for the issuance
and sale of the Preferred Stock (or for Debt Securities convertible into Preferred Stock, or for Warrants exercisable for Preferred Stock
or for Units consisting of or including Preferred Stock) is in an amount that is not less than the par value of the Preferred Stock, and
(b) the rights, preferences, privileges and restrictions, including voting rights, dividend rights, conversion rights, redemption privileges
and liquidation privileges of each series of Preferred Stock will be set forth in a certificate of designation to be approved by the Company’s
Board of Directors, or in an amendment to the Company’s then operative certificate of incorporation (the “Certificate of
Incorporation”), to be approved by the Company’s Board of Directors and stockholders, and that one or both of these documents
will be filed either as an exhibit to an amendment to the Registration Statement to be filed after the date of this opinion or as an exhibit
to a Current Report on Form 8-K to be filed after the Registration Statement has become effective. We have also assumed with respect to
the Debt Securities offered under the Registration Statement and the related Indenture, that such securities will be executed in the form
filed as an exhibit to the Registration Statement and that the Trustee under the Indenture shall have been qualified pursuant to the Trust
Indenture Act of 1939 at the time the Debt Securities are offered or issued (or such later time as may be permitted pursuant to the rules,
regulations, interpretations or positions of the Commission). We have also assumed that (i) with respect to Securities being issued upon
conversion of any convertible Preferred Stock, the applicable convertible Preferred Stock will be duly authorized, validly issued, fully
paid and nonassessable; and (ii) with respect to any Securities being issued upon conversion of any convertible Debt Securities or upon
exercise of any Warrants or relating to any Units, the applicable convertible Debt Securities or Warrants or Units will be valid and legally
binding obligations of the Company, enforceable against the Company in accordance with their terms, except as enforcement may be limited
by applicable bankruptcy, insolvency, reorganization, arrangement, moratorium or other similar laws affecting creditors’ rights,
and subject to general equity principles and to limitations on availability of equitable relief, including specific performance. We have
also assumed with respect to the Warrants offered under the Registration Statement, that (a) such Warrants will be issued pursuant to
a Warrant Agreement, (b) the Warrant Agreement will be filed either as an exhibit to an amendment to the Registration Statement to be
filed after the date of this opinion or as an exhibit to a Current Report on Form 8-K to be filed after the Registration Statement has
become effective, and (c) the particular terms of any series of Warrants will be set forth in a supplement to the prospectus forming a
part of the Registration Statement. We have also assumed with respect to the Units offered under the Registration Statement, that (a)
such Units will be issued pursuant to a Unit Agreement, (b) the Unit Agreement will be filed either as an exhibit to an amendment to the
Registration Statement to be filed after the date of this opinion or as an exhibit to a Current Report on Form 8-K to be filed after the
Registration Statement has become effective, and (c) the particular terms of any series of Units will be set forth in a supplement to
the prospectus forming a part of the Registration Statement.
Notwithstanding anything to the contrary, our
opinion herein is expressed solely with respect to the federal laws of the United States, the Delaware General Corporation Law and, as
to the Debt Securities constituting valid and legally binding obligations of the Company, solely with respect to the laws of the State
of New York. We express no opinion as to any provision of the Debt Securities that: (a) relates to the subject matter jurisdiction of
any federal court of the United States of America or any federal appellate court to adjudicate any controversy related to the Debt Securities
or (b) contains a waiver of an inconvenient forum. We express no opinion as to whether the laws of any jurisdiction are applicable to
the subject matter hereof. We are not rendering any opinion as to compliance with any federal or state law, rule or regulation relating
to securities, or to the sale or issuance thereof. We express no opinions concerning (i) the validity or enforceability of any provisions
contained in indentures that purport to waive or not give effect to rights to notices, defenses, subrogation or other rights or benefits
that cannot be effectively waived under applicable law; or (ii) the validity or enforceability of any provisions contained in Warrant
Agreements or Unit Agreements that purport to waive or not give effect to rights to notices, defenses, subrogation or other rights or
benefits that cannot be effectively waived under applicable law.
On the basis of the foregoing and in reliance thereon, and subject
to the qualifications herein stated, we are of the opinion that:
1. With respect to the Common Stock offered under
the Registration Statement, (other than the Sales Agreement Shares) provided that
(i) the issuance of the Common Stock has been duly authorized by all necessary corporate action on the part of the Company; and (ii) the
certificates for the Common Stock have been duly executed by the Company, countersigned by the transfer agent therefor and duly delivered
to the purchasers thereof against the requisite payment therefor, which the Company has received, the Common Stock, when issued and sold
as contemplated in the Registration Statement, the Base Prospectus and the related Prospectus Supplement(s) and any related free-writing
prospectus(es) and in accordance with any applicable duly authorized, executed and delivered purchase, underwriting or similar agreement,
or upon conversion of any convertible Preferred Stock or convertible Debt Securities in accordance with their terms, or upon exercise
of any Warrants in accordance with their terms, will be duly authorized, validly issued, fully paid and nonassessable.
2. With respect to the Preferred Stock offered
under the Registration Statement, provided that (i) the terms and issuance of the Preferred Stock have been duly authorized by all necessary
corporate action on the part of the Company; (ii) appropriate certificates of amendment to the then operative Certificate of Incorporation
relating to the terms and issuance of Preferred Stock have been duly approved by the Company’s Board of Directors and been filed
with and accepted by the State of Delaware; and (iii) the certificates for the Preferred Stock have been duly executed by the Company,
countersigned by the transfer agent therefor and duly delivered to the purchasers thereof against the requisite payment therefor, which
the Company has received, then the Preferred Stock, when issued and sold as contemplated in the Registration Statement, the Base Prospectus
and the related Prospectus Supplement(s) and any related free-writing prospectus(es) and in accordance with any applicable duly authorized,
executed and delivered purchase, underwriting or similar agreement, or upon conversion of any convertible Debt Securities in accordance
with their terms, or upon exercise of any Warrants in accordance with their terms, will be duly authorized, validly issued, fully paid
and nonassessable.
3. With respect to any series of the Debt Securities
issued under the Indenture and offered under the Registration Statement, provided that (i) the Indenture has been duly authorized by the
Company and the Trustee by all necessary corporate action; (ii) the Indenture in substantially the form filed as an exhibit to the Registration
Statement, has been duly executed and delivered by the Company and the Trustee; (iii) the terms of the Debt Securities and of their issuance
and sale have been duly authorized by the Company by all necessary corporate action; (iv) the terms of the Debt Securities and of their
issuance and sale have been duly established in conformity with the Indenture; and (v) the Debt Securities have been duly executed and
delivered by the Company and authenticated by the Trustee pursuant to the Indenture and delivered against the requisite payment therefor,
which the Company has received, then the Debt Securities, when issued and sold in accordance with the Indenture and as contemplated by
the Registration Statement, the Prospectus and the related Prospectus Supplement(s), and a duly authorized, executed and delivered purchase,
underwriting or similar agreement, will be valid and legally binding obligations of the Company, enforceable against the Company in accordance
with their terms, or upon exercise of any Warrants in accordance with their terms, except as enforcement thereof may be limited by applicable
bankruptcy, insolvency, reorganization, arrangement, moratorium or other similar laws affecting creditors’ rights, and subject to
general equity principles and to limitations on availability of equitable relief, including specific performance.
4. With respect to the Warrants issued under a
Warrant Agreement and offered under the Registration Statement, provided that (i) the Warrant Agreement has been duly authorized by the
Company and the Warrant Agent by all necessary corporate action; (ii) the Warrant Agreement has been duly executed and delivered by the
Company and the Warrant Agent as described in the Registration Statement, the Prospectus and the related Prospectus Supplement(s); (iii)
the issuance and terms of the Warrants have been duly authorized by the Company by all necessary corporate action; and (iv) the Warrants
have been duly executed and delivered by the Company and authenticated by the Warrant Agent pursuant to the Warrant Agreement and delivered
against the requisite payment therefor, which the Company has received, and assuming that the Warrants are then issued and sold as contemplated
in the Registration Statement, the Prospectus and the Prospectus Supplement(s), then the Warrants, when issued and sold in accordance
with the Warrant Agreement and a duly authorized, executed and delivered purchase, underwriting or similar agreement, will be valid and
legally binding obligations of the Company, enforceable against the Company in accordance with their terms, except as enforcement thereof
may be limited by applicable bankruptcy, insolvency, reorganization, arrangement, moratorium or other similar laws affecting creditors’
rights, and subject to general equity principles and to limitations on availability of equitable relief, including specific performance.
5. With respect to the Units issued under a Unit
Agreement and offered under the Registration Statement, provided that (i) the Unit Agreement has been duly authorized by the Company and
the Unit Parties by all necessary corporate action; (ii) the Unit Agreement has been duly executed and delivered by the Company and the
Unit Parties as described in the Registration Statement, the Prospectus and the related Prospectus Supplement(s); (iii) the issuance and
terms of the Units have been duly authorized by the Company by all necessary corporate action; and (iv) the Units have been duly executed
and delivered by the Company and authenticated by the Unit Parties pursuant to the Unit Agreement and delivered against the requisite
payment therefor, which the Company has received, and assuming that the Units are then issued and sold as contemplated in the Registration
Statement, the Prospectus and the Prospectus Supplement(s), then the Units, when issued and sold in accordance with the Unit Agreement
and a duly authorized, executed and delivered purchase, underwriting or similar agreement, will constitute valid and legally binding obligations
of the Company, enforceable against the Company in accordance with their terms, except as enforcement thereof may be limited by applicable
bankruptcy, insolvency, reorganization, arrangement, moratorium or other similar laws affecting creditors’ rights, and subject to
general equity principles and to limitations on availability of equitable relief, including specific performance.
6. With
respect to the Sales Agreement Shares, such Sales Agreement Shares have been duly authorized for issuance and, when the Sales Agreement
Shares have been issued and paid for in accordance with the terms and conditions of the Sales Agreement, the Sales Agreement Shares
will be validly issued, fully paid and non- assessable.
The foregoing opinions are qualified to the extent
that the enforceability of any document, instrument or the Securities may be limited by or subject to bankruptcy, insolvency, fraudulent
transfer or conveyance, reorganization, moratorium or other similar laws relating to or affecting creditors’ rights generally, and
general equitable or public policy principles.
We hereby consent to the filing of this opinion
as an exhibit to the above-referenced Registration Statement and to the use of our name wherever it appears in the Registration Statement,
the Base Prospectus, the Sales Agreement Prospectus and any Prospectus Supplement. In giving such consent, we do not believe that we are
“experts” within the meaning of such term as used in the Securities Act or the rules and regulations of the Commission issued
thereunder with respect to any part of the Registration Statement, including this opinion as an exhibit or otherwise.
This opinion is expressed as of the date hereof
unless otherwise expressly stated, and we disclaim any undertaking to advise you of any subsequent changes in the facts stated or assumed
herein or of any subsequent changes in applicable laws.
Very truly yours, |
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/s/ SHEPPARD, MULLIN, RICHTER & HAMPTON LLP |
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SHEPPARD, MULLIN, RICHTER & HAMPTON LLP |
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-4-
Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING
FIRM
We consent to the incorporation by reference in this
Registration Statement on Form S-3 and related prospectus of our report dated March 30, 2023, with respect to the financial statements
of Unicycive Therapeutics, Inc. as of and for the year ended December 31, 2022, included in the Company’s Annual Report on Form
10-K for the year ended December 31, 2023, and to the reference to us under the heading “Experts” in the prospectus which
is part of this Registration Statement.
/s/ CBIZ CPAs P.C. 1
San Diego, California
November 13, 2024
1 In certain jurisdictions,
CBIZ CPAs P.C. operates under its previous name, Mayer Hoffman McCann P.C.
Exhibit 23.2
Consent of Independent Registered Public Accounting
Firm
We hereby consent to the incorporation by reference
in this Registration Statement on Form S-3 of our report dated March 28, 2024 with respect to the audited financial statements of Unicycive
Therapeutics, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2023, filed with the Securities and Exchange
Commission. We also consent to the reference to our firm under the heading "Experts” appearing therein.
/s/ Grassi & Co, CPAs, P.C.
Grassi & Co., CPAs, P.C.
Jericho, New York
November 13, 2024
Exhibit 107
Calculation of Filing Fee Tables
FORM S-3
(Form Type)
UNICYCIVE THERAPEUTICS, INC.
(Exact Name of Registrant as Specified in its
Charter)
Table 1: Newly Registered Securities
| |
Security
Type | |
Security
Class Title | |
Fee Calculation Rule | |
Amount
Registered(1) | | |
Proposed Maximum Offering Price Per Share(1) | | |
Maximum Aggregate Offering Price(2) | | |
Fee Rate | | |
Amount of Registration Fee(3) | |
Fees to Be Paid | |
Equity Other Debt Other Unallocated (Universal Shelf) | |
Common Stock, par value $0.001 per share Preferred Stock, par value $0.001 per share Debt Securities Warrants Units (4) | |
457(o) | |
| (1 | ) | |
| (1 | ) | |
$ | 100,000,000 | | |
| 0.0001531 | | |
$ | 15,310 | |
| |
| |
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| | |
| |
Total Offering Amounts | | |
| | | |
| | | |
| | | |
$ | 15,310 | |
| |
Total Fees Previously Paid | | |
| | | |
| | | |
| | | |
| — | |
| |
Total Fee Offsets | | |
| | | |
| | | |
| | | |
$ | 4,627.70 | |
| |
Net Fee Due | | |
| | | |
| | | |
| | | |
$ | 10,682.30 | |
Table 2: Fee Offset Claims and Sources
| |
Registrant
or
Filer Name | |
Form
or Filing Type | |
File
Number | |
Initial
Filing Date | |
Filing
Date | |
Fee
Offset Claimed | |
Security
Type
Associated
with Fee
Offset
Claimed | | |
Security
Title Associated with Fee Offset Claimed | |
Unsold
Securities with Fee
Offset Claimed | | |
Unsold
Aggregate Offering Amount Associated with Fee Offset Claimed | | |
Fee
Paid with Fee Offset
Source | |
Rule
457(p) |
Fee
Offset Claims | |
Unicycive,
Therapeutics, Inc. | |
S-3 | |
333-266890 | |
August 16, 2022 | |
N/A | |
$4,627.70(5 | ) |
| Common Stock | | |
(6 | ) |
| (6 | ) | |
$ | 100,000,000 | (2) | |
| N/A | |
Fee
Offset Sources | |
Unicycive,
Therapeutics, Inc. | |
S-3 | |
333-266890 | |
N/A | |
August 16, 2022 | |
N/A | |
| N/A | | |
N/A | |
| N/A | | |
| N/A | | |
$ | 4,635 | (5) |
| (1) | An indeterminate number of securities
or aggregate principal amount, as the case may be, of common stock and preferred stock, such indeterminate principal amount of debt securities,
such indeterminate number of warrants to purchase common stock, preferred stock or debt securities, and such indeterminate number of
units, as shall have an aggregate initial offering price not to exceed $100,000,000. If any debt securities are issued at an original
issue discount, then the offering price of such debt securities shall be in such greater principal amount as shall result in an aggregate
offering price not to exceed $100,000,000 less the aggregate offering price of any securities previously issued hereunder. Any securities
issued hereunder may be sold separately or as units with other securities issued hereunder. The proposed maximum initial offering price
per unit will be determined, from time to time, by the registrant in connection with the issuance by the registrant of the securities
registered hereunder. The securities registered also include such indeterminate amounts and numbers of debt securities, common stock
and preferred stock as may be issuable upon conversion, redemption, exchange, exercise or settlement of any securities registered hereunder,
including under any applicable antidilution provisions. Pursuant to Rule 416(a) under the Securities Act of 1933, as amended
(the “Securities Act”), this registration statement shall be deemed to cover any additional number of securities as may be
offered or issued from time to time upon stock splits, stock dividends, recapitalizations or similar transactions. |
| (2) | The proposed maximum aggregate
offering price per unit will be determined from time to time by the registrant in connection with the sale and issuance by the registrant
of the securities registered hereunder and is not specified as to each class of security pursuant to General Instruction II.F. of
Form S-3 under the Securities Act. |
| (3) | Estimated solely for the purpose
of calculating the registration fee pursuant to Rule 457(o) under the Securities Act. |
| (4) | Any securities registered under the registration statement may
be sold separately or as units with other securities registered under the registration statement. |
| (5) | Pursuant to Rule 457(p), the Registrant has offset $4,627.70 of the
filing fee associated with the $100,000,000 maximum aggregate offering price. $4,627.70 represents the filing fee with respect to $49,921,226
of unsold securities under the Registrant’s Registration Statement on Form S-3 (Registration No. 333-266890) filed on August 16,
2022 ($4,635) and which has been terminated prior to the date of this registration statement. |
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