TIDMIMM

RNS Number : 2513B

Immupharma PLC

30 September 2022

RNS: RELEASE | 30 SEPTEMBER 2022

ImmuPharma PLC

("ImmuPharma" or the "Company")

INTERIM RESULTS

for the six months ended 30 June 2022

ImmuPharma PLC (LSE:IMM) , ("ImmuPharma" or the "Company"), the specialist drug discovery and development company, is pleased to announce its interim results for the six months ended 30 June 2022 (the "Period").

Key Highlights (including post Period review)

Financials

   --   Financial performance in line with expectations over the Period 

o Loss for the Period of GBP1.7m (30 June 2021: GBP3.7m)

o Research and development expenses of GBP1.0m (30 June 2021: GBP1.1m)

o Administrative expenses of GBP0.6m (30 June 2021: GBP0.9m)

o Share based expense of GBP0.1m (30 June 2021: GBP0.3m)

o Cash balance of GBP0.2m as at 30 June 2022 (31 December 2021: GBP1.6m)

o Derivative financial asset of GBP0.6m as at 30 June 2022 (31 December 2021: GBP0.9m)

o Incanthera financial asset of GBP0.6m (GBP1.2m at 31 December 2021) and warrants financial asset of GBPNil (GBP0.2m at 31 December 2021)

o Basic and diluted loss per share of 0.58p (30 June 2021: 1.46p)

o Reorganisation of share capital structure in June 2022

o Successful fundraising in August 2022 raising GBP2.04m (gross), including Lanstead subscription, placement and broker option

o Total proceeds of GBP0.3m from exercise of share options by L1 Capital in August 2022 and in September 2022

'Autoimmunity': Lupuzor(TM) ("P140")

-- P140 Pharmokinetic ("PK") study successfully completed with key endpoints met. P140 was safe and well tolerated across all doses and in all subjects

-- FDA Type C written response received on 14 September 2022: The FDA response was detailed and included significant guidance on next steps for the clinical programme. This included advice on the dosing regime and on study protocol that can be amended to improve the regulatory outcome

-- The Company is currently reviewing the written response with Avion and will make a further notification in due course

-- An adaptive Phase 2/3 clinical study protocol of P140 in CIDP is being finalised for IND submission. Commercial partnering discussions ongoing

'Anti-Infection'

   --    BioAMB - further pre-clinical studies are in preparation 
   --    BioCin - further pre-clinical studies are in preparation 

New website launched: www.immupharma.co.uk

Commenting on the statement and outlook, Tim McCarthy, CEO and Chairman, said :

"The last six months have been pivotal for the Company, positively concluding the PK study of Lupuzor(TM) ("P140") . Post the recent written response from the FDA, in respect to the Lupuzor(TM) Phase 3 protocol, we continue to have positive discussions with our partner, Avion, on the way forward.

The new fundraising, supported by existing and new shareholders, allows us to further invest in the other parts of our product portfolio, whilst being focused on preserving cash where required.

Moving forward, we remain focused on creating a robust and successful Company that, with a diversity of assets, will build future value for our shareholders.

The Board would like to take this opportunity to thank its shareholders for their continued patience and support, as well as its staff, corporate and scientific advisers and our partners including, CNRS and Avion".

Market Abuse Regulation (MAR) Disclosure

THIS ANNOUNCEMENT CONTAINS INSIDE INFORMATION AS STIPULATED UNDER THE UK VERSION OF THE MARKET ABUSE REGULATION NO 596/2014 WHICH IS PART OF UK LAW BY VIRTUE OF THE EUROPEAN UNION (WITHDRAWAL) ACT 2018, AS AMED. ON PUBLICATION OF THIS ANNOUNCEMENT VIA A REGULATORY INFORMATION SERVICE, THIS INFORMATION IS CONSIDERED TO BE IN THE PUBLIC DOMAIN.

 
 
    For further information please contact: 
      ImmuPharma PLC (www.immupharma.co.uk)                  + 44 (0) 2072 062650 
      Tim McCarthy, Chief Executive Officer and Chairman 
      Lisa Baderoon, Head of Investor Relations              + 44 (0) 7721 413496 
      SPARK Advisory Partners Limited (NOMAD) 
       Neil Baldwin                                          +44 (0) 203 36 8 8974 
 
       Stanford Capital Partners (Joint Broker) 
       Patrick Claridge, John Howes                           +44 (0) 203 815 8880 
 
       SI Capital (Joint Broker) 
       Nick Emerson                                           +44 (0) 1483 413500 
 

A copy of the interim report is available on the Company's website www.immupharma.co.uk

ImmuPharma plc

Chairman's Statement

INTERIM HIGHLIGHTS

The first half of 2022 up to the current date has seen a number of key developments for ImmuPharma, including completion of pharmacokinetic ("PK") study of Lupuzor(TM). In addition, in June 2022, our share capital structure has been reorganised and in August 2022, we concluded a successful fundraising.

Lupuzor(TM)

The Board is confident that there are a number of routes to market for Lupuzor(TM), including corporate collaborations. Such a collaboration was successfully completed at the end of November 2019, resulting in a signed exclusive Trademark, License and Development Agreement with Avion Pharmaceuticals ("Avion") in the US. Positive discussions with a number of potential commercial partners for Lupuzor(TM) in key territories outside of the US are continuing.

Lupuzor(TM) and Avion Pharmaceuticals | Background

On 28 November 2019, ImmuPharma and Avion signed an exclusive Trademark, License and Development Agreement for Lupuzor(TM), with Avion agreeing to fund a new international Phase 3 trial and commercialising Lupuzor(TM) in the US.

There have been many meetings following this agreement with both Avion and the FDA, which have been highlighted in numerous announcements.

As part of these discussions, the FDA requested that Avion and ImmuPharma develop and validate a bioanalytical assay in order to confirm the unique pharmacokinetic ("PK") profile of Lupuzor(TM)/ P140, principally to demonstrate that P140 shows a positive result within plasma at the subcutaneous level.

The P140 PK study was successfully completed, as announced on 13 April 2022, with all key endpoints requested by the FDA being met. The key highlights from the study were summarised as below.

Subcutaneous injection of P140 (in both 200 microgram ("mcg") and 800 mcg doses (note: 1mcg = 1 millionth of a gram) showed a clear time and dose-related PK profile, which is detectable in the blood of human volunteers and applicable for all potential clinical dosing regiments of P140.

The final group of subjects completed dosing on 30 March 2022. This was a group of subjects that received an intravenous injection of a 800 mcg dose of P140, which showed successful measurement of the absolute bioavailability of the drug (as a control). In line with all human dosing to date, P140 was safe and well tolerated across all doses and in all subjects.

Avion, our US partner, has been integral to the development, initiation and successful conclusion of this PK study.

On 27 June 2022 Avion submitted, via a Type C Meeting, the positive results from the Lupuzor(TM)/P140 PK study to the FDA.

The FDA response, reported on 14 September 2022 was detailed and included significant guidance on next steps for the clinical programme. This included advice on the dosing regime and on study protocol that can be amended to improve the regulatory outcome.

The Company is currently reviewing the written response with Avion and will make a further notification in due course.

Pipeline Overview

ImmuPharma's pipeline is focused on two core therapeutic areas:

   --    Autoimmunity & Inflammation 
   --    Anti-Infectives 

Autoimmunity & Inflammation

The increasing knowledge of P140's mode of action and its relevance to many autoimmune and inflammatory conditions provides a depth of disease states for ImmuPharma and its partners to explore in the near future. The therapeutic potential of P140 goes beyond just lupus, with Chronic Inflammatory Demyelinating Polyneuropathy ("CIDP") being the next step. This expanding insight is fundamentally driven by the excellent research partnership between the Company and Prof. Sylviane Muller, inventor of P140 and Emeritus Research Director CNRS, France. Key highlights within the progression of the P140 platform are summarized below:

o Lupuzor(TM) (P140) - successfully completed PK study

o P140 - CIDP a neurological disorder targeting the body's nerves. An adaptive Phase 2/3 clinical study protocol is being finalised for IND submission

o P140 - Other indications. Further clinical applications based on further preclinical investigation include asthma, Sjögrens syndrome, irritable bowel disease, periodontitis and gout

o P140 - Second generation. 'ImmuPharma Biotech' has commenced work to develop a pharmacologically improved version of P140, a second-generation product that aims to further strengthen the IP position and provide therapies with different improved administration modalities, yet still maintaining P140 as the active moiety

Anti-Infectives

The innovative peptide technology at ImmuPharma Biotech has been a huge success and very recently has given rise to a number of novel development programs, out of which we have identified two core programs, in pre-clinical development; BioAMB and BioCin, which we believe have the best commercial opportunity and speed to market.

o BioAMB, a novel peptide-based drug that offers a potential improvement on the limiting side effects and poor administration regime of current Amphotericin-B ("AMB") formulations. AMB is one of a last line of agents against serious and life-threatening fungal infections caused by the aspergillus family of fungi

o BioCin, a novel peptide-based drug based on an existing potent antibacterial used in high medical need cases and in many cases the last line of defense. BioCin has the potential to offer improved safety and/or administration benefits

Capital restructure

At the Annual General Meeting on 28 June 2022, the shareholders approved the subdivision of the Company's ordinary share capital, whereby each existing Ordinary Share with a nominal value of 10p was subdivided into 1 new Ordinary Share of 1p and 1 Deferred Share of 9p. The Deferred Shares have no significant rights attached to them and carry no right to vote or to participate in distribution of surplus assets and are not admitted to trading on the AIM market of the London Stock Exchange plc. The Deferred Shares effectively carry no value.

Capital subscription

In August 2022, ImmuPharma completed a successful fundraising totalling GBP2.04m (before expenses) through the issue of 40,818,182 new ordinary shares of 1p each in ImmuPharma, at a price of 5p per ordinary share ("Issue Price").

The highlights of the August 2022 fundraising are outlined below:

o Subscription for 20,000,000 new ordinary shares by Lanstead Capital Investors L.P. "Lanstead" to raise GBP1 million (at 5p per share)

o "Placing" of 1,818,182 new ordinary shares to raise GBP0.09 million at the price of 5p.

o "Broker Option" raised an additional GBP0.95 million, for 19 million shares at the price of 5p per share. Certain the Directors (Tim McCarthy, Dr Tim Franklin, Lisa Baderoon) subscribed to GBP0.1m in total in the Broker Option (GBP60,000, GBP20,000, GBP20,000 respectively).

o 200,000 new ordinary shares ("Fee Shares") at an issue price of 5p per share to SPARK Advisory Partners Limited, the Company's nominated adviser, in lieu of fees.

Lanstead subscription

The GBP1 million gross proceeds of the Lanstead subscription were followed by the Sharing Agreement with Lanstead for 100% of these shares with a reference price of 6.6667p per share ("Benchmark Price"). The Sharing Agreement is for a 24 month period and the Company will receive 24 equal monthly settlements, as measured against Benchmark Price. The actual consideration is variable depending upon ImmuPharma's share price, which needs to be on average (over the 24 months of the sharing agreement) at or above the Benchmark price for the Company to receive at least, or more than, the gross subscription of GBP1 million.

For example, if on a monthly settlement date the calculated "Measured Price" (average of twenty day ImmuPharma share VWAP) exceeds the Benchmark Price by 10 per cent, the settlement on that monthly settlement date will be 110 per cent of the amount due from Lanstead on that date. If on the monthly settlement date the calculated "Measured Price" is below the Benchmark Price by 10 per cent, the settlement on the monthly settlement date will be 90 per cent of the amount due on that date.

The Company also agreed to issue Lanstead 1,400,000 ordinary shares in connection with entering into the Sharing Agreement ("Value Payment Shares").

Impact on L1/Lind arrangement

The 25,640,254 options in the Company, held equally by L1 Capital Global Opportunities Master Fund "L1" and Lind Global Macro Fund, LP "Lind" issued on 11 June 2020, exercisable at any time up to 10 June 2023, at 11p have been amended, as a result of the August 2022 fundraising of issuing shares below 11p. The effect of the current fundraising is to amend the exercise price of this options from 11p to 5p and to increase the number of options held by L1 and Lind from 25,640,254 to 56,408,558.

Warrants

In August 2022, Lanstead was issued 30,000,000 warrants (for 10 years term), with an exercise price of 5.5p per share in return for foregoing the entitlement to increase the benchmark price by 50% (from 14.6667p to 22p) in relation to the 2021 sharing agreement (due to the amendment made to L1 and Lind option arrangements).

In August 2022, Stanford Capital Partners ("SCP"), the Company's broker, was issued 2,000,000 warrants with an exercise price of 5p per share for the period of 10 years, in lieu of fees.

In August 2022, SCP and SI Capital were issued 500,000 warrants each, for a period of 10 years, in lieu of fees, as part of the "Broker Option".

Exercise of options

On 24 August 2022, L1 has exercised options over 1,000,000 new ordinary shares of 1p each at an exercise price of 5p per share, for a consideration of GBP50,000.

On 30 August 2022, L1 has exercised options over 2,000,000 new ordinary shares of 1p each at an exercise price of 5p per share, for a consideration of GBP100,000.

On 7 September 2022, L1 has exercised options over 3,000,000 new ordinary shares of 1p each at an exercise price of 5p per share, for a consideration of GBP150,000.

Interest in Incanthera Plc

ImmuPharma has a 13.37% interest in Incanthera plc, which trades on Aquis Stock Exchange ("AQSE") under the ticker (TIDM:INC).

ImmuPharma also has 7,272,740 warrants options in Incanthera at an exercise price of 9.5p, being the price at which new shares have been issued in the Placing accompanying Incanthera's listing.

Please refer to Incanthera's website for further updates on the company ( www.incanthera.com ).

Financial Review

ImmuPharma's cash balance at 30 June 2022 was GBP0.2 million (GBP1.6 million at 31 December 2021, GBP4.2 million at 30 June 2021) with the decrease in the Period caused by the research and development expenditure related to PK study. Financial asset related to investment in Incanthera plc amounted to GBP0.6 million (GBP1.2 million at 31 December 2021, GBP1.2 million at 30 June 2021) and warrants (recognized under financial asset) decreased to GBPNil (GBP0.2 million at 31 December 2021 and GBP0.2 million at 30 June 2021). The decrease was due to the fair value loss on the investment in shares in the Incanthera plc, following the decrease in its share price to 6p at 30 June 2022 compared to 12.2p at 31 December 2021.

As a result of the Lanstead Sharing Agreements, the Company had a derivative financial asset of GBP0.6 million at 30 June 2022 (GBP0.9 million at 31 December 2021, GBP0.2 million at 30 June 2021). The decrease was a result of the fair value calculation performed at 30 June 2022, reflecting the decrease in ImmuPharma's share price. Current tax asset amounted to GBP0.6 million at 30 June 2022 (GBP0.8 million at 31 December 2021, GBP0.2 million at 30 June 2021) and it's related to research and development tax credit due. The convertible loans liability has been repaid in full in 2021, therefore it has a GBPNil balance (GBPNil at 31 December 2021, GBP0.7 million at 30 June 2021). Trade and other payables liability decreased to GBP0.9 million at 30 June 2022 (GBP1.6 million at 31 December 2021, GBP1.1 million at 30 June 2021) and was largely due to payments made for PK study related expenditures. Basic and diluted loss per share were 0.58p and 0.58p respectively (30 June 2021: 1.46p and 1.46p). In line with the Company's current policy, no interim dividend is proposed.

Operating loss for the Period was GBP1.7 million (GBP3.1 million for the six months ended 30 June 2021). Research and development expenditure in the Period was GBP1 million (GBP1.1 million for the six months ended 30 June 2021). Administrative expenses decreased to GBP0.6 million during the Period (GBP0.9 million for the six months ended 30 June 2021), largely due to savings made on corporate reorganization. The share based expense amounted to GBP0.1 million (GBP0.3 million for the six months ended 30 June 2021). Finance costs for the Period were GBP0.2 million (GBP0.9 million for the six months ended 30 June 2021). These arose largely due to the calculation of fair value of the derivative financial asset - "Lanstead Sharing Agreements", which resulted in a finance loss of GBP0.2 million (GBP0.8 million of finance loss for the six months ended 30 June 2021). The finance loss was significant for the six months ended 30 June 2021, due to the impact of the adjustment to the Lanstead Sharing Agreements' benchmark price from 13.33p to 20p. Finance income for the Period was GBP0.02 million (GBP0.1 million for the six months ended 30 June 2021). It primarily arose due to foreign exchange gain.

Given the stage of ImmuPharma's development, the fact that losses have continued to be made is to be expected since there is minimal revenue and business activity is concerned with significant investment in the form of clinical development expenditure, in addition to maintaining the infrastructure of the Company.

Current activities and outlook

The last six months have been pivotal for the Company, positively concluding the PK study of Lupuzor(TM) ("P140") . Post the recent written response from the FDA, in respect to the Lupuzor(TM) Phase 3 protocol, we continue to have positive discussions with our partner, Avion, on the way forward.

The new fundraising, supported by existing and new shareholders, allows us to further invest in the other parts of our product portfolio, whilst being focused on preserving cash where required.

Moving forward, we remain focused on creating a robust and successful Company that, with a diversity of assets, will build future value for our shareholders.

The Board would like to take this opportunity to thank its shareholders for their continued patience and support, as well as its staff, corporate and scientific advisers and our partners including, CNRS and Avion.

Tim McCarthy

Chairman & Chief Executive Officer

ImmuPharma plc

CONSOLIDATED INCOME STATEMENT

FOR THE PERIODED 30 JUNE 2022

 
                                               Unaudited         Audited        Unaudited 
                                                6 months      Year ended         6 months 
                                                   ended     31 December            ended 
                                     Note        30 June            2021          30 June 
                                                    2022                             2021 
                                                                                restated* 
                                                     GBP             GBP              GBP 
  Continuing operations 
  Revenue                                              -       118,350             23,531 
  Research and development 
   expenses                                  (1,042,917)     (3,650,400)      (1,054,875) 
  Administrative expenses                      (555,600)     (1,011,398)        (913,516) 
  Exceptional items                  6                 -     (1,427,084)        (846,792) 
  Share based expense                           (70,994)       (616,423)        (288,826) 
 
 
    Operating loss                           (1,669,511)     (6,586,955)      (3,080,478) 
 
  Finance costs                      4         (176,665)     (2,354,872)        (904,549) 
  Finance income                                  16,364           1,107           95,225 
 
 
  Loss before taxation                       (1,829,812)     (8,940,720)      (3,889,802) 
 
  Tax                                            166,024         766,815          229,919 
 
 
  Loss for the period                        (1,663,788)     (8,173,905)      (3,659,883) 
 
 
  Attributable to: 
  Equity holders of the parent 
   company                                   (1,663,788)     (8,173,905)      (3,659,883) 
 
 
  Loss per ordinary share 
 
  Basic and diluted                  2           (0.58)p         (3.25)p          (1.46)p 
 
 

* The presentation of the income statement for the comparative period ended 30 June 2021 has been restated to show exceptional items as a separate line, consistent with the presentation for the full year income statement for the year ended 31 December 2021.

ImmuPharma plc

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

FOR THE PERIODED 30 JUNE 2022

 
                                             Unaudited          Audited      Unaudited 
                                              6 months             Year       6 months 
                                                 ended            ended          ended 
                                               30 June      31 December        30 June 
                                                  2022             2021           2021 
                                                   GBP              GBP            GBP 
 
  Loss for the financial period            (1,663,788)      (8,173,905)    (3,659,883) 
 
 
  Other comprehensive income 
  Items that will not be reclassified 
   subsequently to profit or loss: 
  Fair value loss on investment              (614,068)        (584,355)      (555,633) 
  Fair value loss on warrants                (206,411)        (418,068)      (395,640) 
 
 
  Total items that will not be 
   reclassified subsequently to 
   profit or loss                            (820,479)      (1,002,423)      (951,273) 
 
 
  Items that may be reclassified 
   subsequently to profit or loss: 
  Exchange differences on translation 
   of foreign operations                        16,350         (36,177)       (20,357) 
 
 
  Total items that may be reclassified 
   subsequently to profit or loss               16,350         (36,177)       (20,357) 
 
  Other comprehensive loss for 
   the period                                (804,129)      (1,038,600)      (971,630) 
 
 
  Total comprehensive loss for 
   the period                              (2,467,917)      (9,212,505)    (4,631,513) 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

AS AT 30 JUNE 2022

 
                                    Note       Unaudited              Audited            Unaudited 
                                                6 months                 Year             6 months 
                                                   ended                ended                ended 
                                                 30 June          31 December              30 June 
                                                    2022                 2021                 2021 
                                                     GBP                  GBP                  GBP 
  Non-current assets 
  Intangible assets                              471,534              477,553              495,736 
  Property, plant and equipment                  330,835              352,996              369,700 
   Financial asset                               595,355            1,415,835            1,466,985 
  Derivative financial asset         4           196,488              405,489                    - 
 
 
  Total non-current assets                     1,594,212            2,651,873            2,332,421 
 
 
  Current assets 
  Trade and other receivables                    114,450              427,199              129,850 
  Cash and cash equivalents                      170,922            1,649,374            4,248,412 
  Current tax asset                              595,205              761,188              211,180 
  Derivative financial asset         4           400,306              508,167              160,436 
 
 
  Total current assets                         1,280,883            3,345,928            4,749,878 
 
 
  Current liabilities 
  Financial liabilities - 
   borrowings                                      (230)                (700)                (914) 
  Trade and other payables                     (858,291)          (1,583,604)          (1,113,465) 
  Convertible loans                                    -                    -            (655,811) 
 
 
  Total current liabilities                    (858,521)          (1,584,304)          (1,770,190) 
 
 
  Net current assets                             422,362            1,761,624            2,979,688 
 
 
 
 
  Net assets                                   2,016,574            4,413,497            5,312,109 
 
 
  EQUITY 
  Ordinary shares                    5         2,849,849           28,498,494           25,022,130 
  Deferred shares                    5        25,648,645                    -                    - 
  Share premium                               27,237,329           27,237,329           27,237,329 
  Merger reserve                                 106,148              106,148              106,148 
  Other reserves                               5,240,503            5,153,159            3,524,005 
  Retained earnings                         (59,065,900)         (56,581,633)         (50,577,503) 
 
 
  Total equity                                 2,016,574            4,413,497            5,312,109 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

FOR THE PERIODED 30 JUNE 2022

 
 
 
 
                                                                                                                               Other 
                                                                                                                            reserves 
                                                                                                               Other               - 
                                                                                  Other           Other     reserves     Convertible        Other 
                                                                               reserves        reserves       -Share          option     reserves 
                                                      Share      Merger               -               -        based         reserve            -        Retained 
                       Ordinary      Deferred       premium     Reserve     Acquisition     Translation      payment             GBP      Warrant         Earning          Total 
                         shares        shares           GBP         GBP         Reserve         Reserve      reserve                      reserve            GBPs         Equity 
                            GBP           GBP                                       GBP             GBP          GBP                          GBP                            GBP 
   At 1 January 
    2021             25,022,130             -    27,237,329     106,148     (3,541,203)     (1,308,480)    8,073,596          31,623            -    (45,966,347)      9,654,796 
   Loss for the 
    financial 
    period                    -             -             -           -               -               -            -               -                  (3,659,883)    (3,659,883) 
   Exchange 
    differences               -             -             -           -               -        (20,357)            -               -                            -       (20,537) 
   Share based 
    payments                  -             -             -           -               -               -      288,826               -                            -        288,826 
   Equity                     -             -             -           -               -               -            -               -                            -              - 
   component 
   of 
   convertible 
   loan notes 
   Fair value 
    loss 
    on 
    investments               -             -             -           -               -               -            -               -                    (555,633)      (555,633) 
   Fair value 
    loss 
    on warrants               -             -             -           -               -               -            -               -                    (395,640)      (395,640) 
   At 30 June 
    2021 
    unaudited        25,022,130             -    27,237,329     106,148     (3,541,203)     (1,328,837)    8,362,422          31,623            -    (50,577,503)      5,312,109 
 
   At 1 January 
    2021             25,022,130             -    27,237,329     106,148     (3,541,203)     (1,308,480)    8,073,596          31,623            -    (45,966,347)      9,654,796 
   Loss for the 
    financial 
    year                      -             -             -           -               -     -                      -               -                  (8,173,905)    (8,173,905) 
   Exchange 
    differences               -             -                         -               -        (36,177)            -               -                            -       (36,177) 
   Share based 
    payments                  -             -             -           -               -               -      616,423               -                            -        616,423 
   Settlement 
    of 
    convertible 
    loans 
    reserves                                                                                                                (31,623)                       31,623              - 
   New issue of 
    equity 
    capital           3,476,364             -       322,727           -               -               -            -               -                  (1,349,000)      2,450,091 
   Cost of new 
    issue of 
    equity 
    capital                   -             -     (322,727)           -               -               -            -               -                    (121,581)      (444,308) 
   Fair value 
    loss 
    o n 
    investments               -             -             -           -               -               -            -               -                    (584,355)      (584,355) 
   Fair value 
    loss 
    on warrants               -             -             -           -               -               -            -               -                    (418,068)      (418,068) 
   Issue of 
    warrants                                -                                                                                           1,349,000               -      1,349,000 
   At 31 
    December 
    2021 & 1 
    January 
    2022 
    audited         28,498,494              -    27,237,329     106,148     (3,541,203)     (1,344,657)    8,690,019               -    1,349,000    (56,581,633)      4,413,497 
 
   Loss for the 
    financial 
    period                    -             -             -           -               -               -            -               -            -     (1,663,788)    (1,663,788) 
   Exchange 
    differences               -             -             -           -               -          16,350            -               -                            -         16,350 
   Share split     (25,648,645)    25,648,645                                                                                                                                  - 
   Share based 
    payments                  -             -             -           -               -               -       70,994               -            -               -         70,994 
   Fair value 
    loss 
    on 
    investments               -             -             -           -               -               -            -               -            -       (614,068)      (614,068) 
   Fair value 
    loss 
    on warrants               -             -             -           -               -               -            -               -            -       (206,411)      (206,411) 
   At 30 June 
    2022 
    unaudited         2,849,849    25,648,645    27,237,329     106,148     (3,541,203)     (1,328,307)    8,761,013               -    1,349,000    (59,065,900)      2,016,574 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CASHFLOWS

FOR THE PERIODED 30 JUNE 2022

 
                                        Note      Unaudited         Audited        Unaudited 
                                                   6 months            Year         6 months 
                                                      ended           ended            ended 
                                                    30 June     31 December          30 June 
                                                       2022            2021             2021 
                                                        GBP             GBP              GBP 
  Cash flows from operating 
   activities 
  Cash used in operations                3      (1,966,598)     (5,222,446)      (2,068,937) 
 
    Tax received                                    343,246         392,217          390,418 
  Interest paid                                       (922)         (2,943)          (1,444) 
 
 
    Net cash used in operating 
    activities                                  (1,624,274)     (4,833,172)      (1,679,963) 
 
 
  Investing activities 
  Purchase of property, 
   plant and equipment                                    -        (50,934)         (48,014) 
  Purchase of intangibles                                 -               -          (4,756) 
  Interest received                                      63             651              215 
 
  Net cash (used in)/generated 
   from investing activities                             63        (50,283)         (52,555) 
 
 
  Financing activities 
  Decrease in bank overdraft                              -           (211)                5 
  New loans/(loan repayments)                         (470)         (6,028)          (5,751) 
  Settlements from Sharing 
   Agreement                                        143,273         328,495          261,116 
  Gross proceeds from issue                               -       3,550,000                - 
   of new share capital 
  Share capital issue costs                               -       (132,350)                - 
  Funds deferred per Sharing                              -     (2,200,000)                - 
   Agreement 
  Interest paid on convertible                            -       (121,120)                - 
   loan notes 
  Convertible loan notes repaid                           -       (716,739)                - 
 
 
  Net cash generated from financing 
   activities                                       142,803         702,047          255,370 
 
  Net (decrease) in cash and 
   cash equivalents                             (1,481,408)     (4,181,408)      (1,477,148) 
  Cash and cash equivalents 
   at start of period                             1,649,374       5,862,057        5,862,057 
 
    Effects of exchange rates 
    on cash and 
    cash equivalents                                  2,956        (31,275)        (136,497) 
 
 
    Cash and cash equivalents 
    at end of period                                170,922       1,649,374        4,248,412 
 
 
 

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIODED 30 JUNE 2022

   1          ACCOUNTING POLICIES 

Basis of preparation

The interim financial information in this report has been prepared using accounting policies consistent with IFRS as adopted by the United Kingdom. IFRS is subject to amendment and interpretation by the International Accounting Standards Board (IASB) and the IFRS Interpretations Committee and there is an ongoing process of review and endorsement by the UK Endorsement Board. The financial information has been prepared on the basis of IFRS expected to be adopted by the United Kingdom and applicable as at 31 December 2022. The Group has chosen not to adopt IAS 34 "Interim Financial Statements" in preparing the interim financial information.

The accounting policies applied are consistent with those that were applied to the financial statements for the year ended 31 December 2021.

Non-Statutory accounts

The financial information set out in this interim report does not constitute the Group's statutory accounts, within the meaning of Section 434 of the Companies Act 2006. The statutory accounts for the year ended 31 December 2021 have been filed with Registrar of Companies. The auditors reported on those accounts; their report was unqualified, did not contain a statement under either Section 498 (2) or Section 498 (3) of the Companies Act 2006 but did include emphasis of matter paragraph relating to the carrying value of Parent Company's investment in subsidiaries and receivables due from group undertakings, and a reference to which the auditor drew attention by way of emphasis without qualifying their report in respect of going concern.

Copies of this statement will be available on the Company's website - www.immupharma.co.uk.

   2              LOSS PER SHARE 
 
                                          Unaudited         Audited       Unaudited 
                                           6 months            Year        6 months 
                                              ended           ended           ended 
                                            30 June     31 December         30 June 
                                               2022            2021            2021 
                                                GBP             GBP             GBP 
 
  Loss 
  Loss for the purposes of basic 
   and diluted loss per share 
   being net loss attributable 
   to equity shareholders               (1,663,788)     (8,173,905)     (3,659,883) 
 
 
  Number of shares 
  Weighted average number of 
   ordinary shares for the purposes 
   of basic loss per share              284,984,933     251,164,361     250,221,297 
 
 
 
    Basic loss per share                    (0.58)p         (3.25)p         (1.46)p 
 
 
 
  Diluted loss per share                    (0.58)p         (3.25)p         (1.46)p 
 
 
 

There is no difference between basic loss per share and diluted loss per share as the share options and warrants are anti-dilutive. Deferred shares are excluded from the loss per share calculation as they have no attributable earnings.

 
  3                                 CASH USED IN OPERATIONS 
                                                 Unaudited          Audited        Unaudited 
                                                  6 months             Year         6 months 
                                                     ended            ended            ended 
                                                   30 June      31 December          30 June 
                                                      2022             2021             2021 
                                                       GBP              GBP              GBP 
 
   Operating loss                              (1,669,511)      (6,586,955)      (3,080,478) 
   Depreciation & amortisation                      37,212          114,119         86,639 
   Share based payments                             70,994          616,423        288,826 
   Decrease/(increase) in trade 
    & other receivables                            312,749        (265,201)           29,964 
   Increase/(decrease) in trade 
    & other payables                             (725,313)          896,798          511,100 
   Gain on foreign exchange                          7,271            2,370           95,012 
 
 
     Cash used in operations                   (1,966,598)      (5,222,446)      (2,068,937) 
 
 
 
 
  4    Derivative Financial Asset 
 
        As part of the placement completed in June 2019, the Company 
        issued 26,565,200 new ordinary shares to Lanstead Capital 
        Investors L.P. ("Lanstead") at a price of 10p per share 
        for an aggregate subscription price of GBP2.66m before expenses. 
        In the placement completed in March 2020, the Company issued 
        13,000,000 new ordinary shares to Lanstead at a price of 
        10p per share to raise GBP1.3m gross. In December 2021, 
        the Company issued 20,000,000 new ordinary shares to Lanstead 
        at a price of 11p per share to raise GBP2.2m before expenses. 
        All Subscriptions proceeds were pledged under the Sharing 
        Agreement, under which Lanstead made and will continue to 
        make, subject to the terms and conditions of that Sharing 
        Agreement, monthly settlements to the Company that are subject 
        to adjustment upwards or downwards depending on the Company's 
        share price performance. 
 
        In December 2021 the Company also issued 1,400,000 new ordinary 
        shares to Lanstead as value payments in connection with 
        the Share Subscription and the Sharing Agreement. Monthly 
        settlements under the Sharing Agreement from June 2019 completed 
        in September 2021. The settlements from remaining agreements 
        (March 2020 and December 2021) will continue until 2024, 
        completing in July 2022 and March 2024 respectively. 
 
        At the end of the accounting period the amount receivable 
        has been adjusted to fair value based upon the share price 
        of the Company at that date. Any change in the fair value 
        of the derivative financial asset is reflected in the income 
        statement. As at 30 June 2022, the Company completed a calculation 
        of fair value of the derivative financial asset that resulted 
        in a finance loss of GBP175,742 (GBP769,570 at 30 June 2021), 
        which was recorded in the income statement. The restatement 
        to fair value will be calculated at the end of each accounting 
        period during the course of the Sharing Agreement and will 
        vary according to the Company's share price performance. 
 
 
 
 
   5              Issued share capital 
 
  Allotted, called       30 June         31 December     30 June 2022     31 December 
   up and fully paid      2022            2021 No.        GBP              2021 GBP 
   Ordinary Shares        No. 
  At start of period 
   of GBP0.10 each 
   Split to deferred     284,984,933     250,221,297     28,498,494       25,022,130 
   shares of GBP0.09 
   each                   -               -               (25,648,645)     - 
   Shares issued 
   in the period          -               -               -                - 
 
   At end of period 
   of GBP0.01 each        284,984,933     250,221,297     2,849,849        25,022,130 
                       --------------  --------------  ---------------  ------------- 
 
 
  Allotted, called         30 June         31 December    30 June 2022    31 December 
   up and fully paid        2022            2021 No.       GBP             2021 GBP 
   Deferred Shares          No. 
  At start of period 
   Split from Ordinary     -               -              -               - 
   Shares of GBP0.09        284,984,933     -              25,648,645      - 
   each 
 
   At end of period 
   of GBP0.09 each          284,984,933     -              25,648,645      - 
                         --------------  -------------  --------------  ------------- 
 

Capital restructure

At Annual General Meeting on 28 June 2022 the shareholders approved the subdivision of the Company's ordinary share capital, whereby each existing Ordinary Share with a nominal value of 10p was subdivided into 1 new Ordinary Share of 1p and 1 Deferred Share of 9p. The Deferred Shares have no significant rights attached to them and carry no right to vote or to participate in distribution of surplus assets and are not admitted to trading on the AIM market of the London Stock Exchange plc. The Deferred Shares effectively carry no value.

   6.             Exceptional items 

There were no exceptional items in the Period (GBP1.4 million at 31 December 2021, GBP0.8 million at 30 June 2021). Exceptional items related to termination benefit packages paid out in 2021.

   7.             Subsequent events 

In August 2022 ImmuPharma secured successful fundraising totalling to GBP2.04m (before expenses) through the issue of 40,818,182 new ordinary shares of 1p each in ImmuPharma at a price of 5p per ordinary share ("Issue Price").

The highlights of the August 2022 fundraising are outlined below:

o -Subscription for 20,000,000 new ordinary shares by Lanstead Capital Investors L.P. "Lanstead" to raise GBP1 million (at 5p per share).

o -"Placing" of 1,818,182 new ordinary shares to raise GBP0.09 million at the price of 5p.

o -"Broker Option" raised an additional GBP0.95 million, for 19 million shares at the price of 5p per share. Certain of the Directors (Tim McCarthy, Dr Tim Franklin, Lisa Baderoon) subscribed GBP0.1m in total in the Broker Option (GBP60,000, GBP20,000, GBP20,000 respectively).

o -200,000 new ordinary shares ("Fee Shares") at an issue price of 5p per share to SPARK Advisory Partners Limited, the Company's nominated adviser, in lieu of fees.

Lanstead subscription

The GBP1 million gross proceeds of the Lanstead subscription was followed by the Sharing Agreement with Lanstead for 100% of these shares with a reference price of 6.6667p per share ("Benchmark Price"). The Sharing Agreement is for a 24 month period and the Company will receive 24 equal monthly settlements, as measured against Benchmark Price. The actual consideration is variable depending upon ImmuPharma's share price, which needs to be on average (over the 24 months of the sharing agreement) at or above the Benchmark price for the Company to receive at least, or more than, the gross subscription of GBP1 million.

For example, if on a monthly settlement date the calculated "Measured Price" (average of twenty day ImmuPharma share VWAP) exceeds the Benchmark Price by 10 per cent, the settlement on that monthly settlement date will be 110 per cent of the amount due from Lanstead on that date. If on the monthly settlement date the calculated "Measured Price" is below the Benchmark Price by 10 per cent, the settlement on the monthly settlement date will be 90 per cent of the amount due on that date.

The Company also agreed to issue Lanstead 1,400,000 ordinary shares in connection with entering into the Sharing Agreement ("Value Payment Shares").

Impact on L1/Lind arrangement

The 25,640,254 options in the Company, held equally by L1 and Lind, (issued in June 2020) exercisable at any time up to 10 June 2023, at 11p have been amended, as a result of the August 2022 fundraising of issuing shares below 11p. The effect of the current fundraising is to amend the exercise price of these options from 11p to 5p and to increase the number of options held by L1 and Lind from 25,640,254 to 56,408,558.

Warrants

In August 2022, Lanstead was issued 30,000,000 warrants (for 10 years term), with an exercise price of 5.5p per share in return for foregoing the entitlement to increase the benchmark price by 50% (from 14.6667p to 22p) in relation to the 2021 sharing agreement (due to the amendment made to L1 and Lind option arrangements).

In August 2022, Stanford Capital Partners "SCP"- the Company's broker was issued 2,000,000 warrants with an exercise price of 5p per share for the period of 10 years, in lieu of fees.

In August 2022, SCP and SI Capital were issued 500,000 warrants each, for the period of 10 years, in lieu of fees, as part of the "Broker Option".

Exercise of options

On 24 August 2022, L1 has exercised options over 1,000,000 new ordinary shares of 1p each at an exercise price of 5p per share, for a consideration of GBP50,000.

On 30 August 2022, L1 has exercised options over 2,000,000 new ordinary shares of 1p each at an exercise price of 5p per share, for a consideration of GBP100,000.

On 7 September 2022, L1 has exercised options over 3,000,000 new ordinary shares of 1p each at an exercise price of 5p per share, for a consideration of GBP150,000.

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END

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September 30, 2022 02:00 ET (06:00 GMT)

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