FORM 4 [X] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

GUY GEOFFREY W DR		 2. Issuer Name and Ticker or Trading Symbol

GW PHARMACEUTICALS PLC [ GWPH ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Executive Chairman
(Last)          (First)          (Middle)

SOVEREIGN HOUSE, VISION PARK, HISTON		 3. Date of Earliest Transaction (MM/DD/YYYY)

5/5/2021
(Street)

CAMBRIDGE, X0 CB24 9BZ
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Ordinary Shares 5/5/2021  D  4781521 D (1)(2)0 D  
Ordinary Shares 5/5/2021  D  25000 D (1)(2)0 I By wife 
Ordinary Shares 5/5/2021  D  103925 D (1)(2)0 I By personal pension plan 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Share Options $8.3767 5/5/2021  D     138672   (3)8/10/2027 Ordinary Shares 138672  (3)0 D  
Share Options $0.0017 5/5/2021  D     15336   (3)8/10/2027 Ordinary Shares 15336  (3)0 D  
Share Options $9.6092 5/5/2021  D     107352   (3)2/26/2028 Ordinary Shares 107352  (3)0 D  
Share Options $0.0017 5/5/2021  D     217572   (3)2/26/2028 Ordinary Shares 217572  (3)0 D  
Share Options $0.0017 5/5/2021  D     32616   (3)2/26/2028 Ordinary Shares 32616  (3)0 D  
Share Options $14.3342 5/5/2021  D     75252   (3)3/1/2029 Ordinary Shares 75252  (3)0 D  
Share Options $0.0017 5/5/2021  D     142824   (3)3/1/2029 Ordinary Shares 142824  (3)0 D  
Share Options $0.0017 5/5/2021  D     32112   (3)3/1/2029 Ordinary Shares 32112  (3)0 D  
Share Options $0.0017 5/5/2021  D     233604   (3)6/4/2030 Ordinary Shares 233604  (3)0 D  
Share Options $0.0017 5/5/2021  D     140160   (3)6/4/2030 Ordinary Shares 140160  (3)0 D  
Share Options $0.0017 5/5/2021  D     131712   (4)2/22/2031 Ordinary Shares 131712  (4)0 D  
Share Options $0.0017 5/5/2021  D     82320   (4)2/22/2031 Ordinary Shares 82320  (4)0 D  
Explanation of Responses:
(1) On May 5, 2021, Jazz Pharmaceuticals Public Limited Company, a public limited company incorporated in the Republic of Ireland ("Jazz"), Jazz Pharmaceuticals UK Holdings Limited, a private limited company incorporated in England and Wales and an indirect wholly owned subsidiary of Jazz ("Bidco") and the DR Nominee (as defined in the Transaction Agreement) acquired all outstanding ordinary shares, par value British Pound Sterling 0.001 per share, of GW Pharmaceuticals plc, a public limited company incorporated in England and Wales (the "Company"), by means of a scheme of arrangement under Part 26 of the UK Companies Act 2006 (the "Scheme of Arrangement") (continued in footnote 2).
(2) At the effective time of the Scheme of Arrangement, Scheme Shareholders (as defined in the Scheme of Arrangement) became entitled to receive for each Scheme Share (as defined in the Scheme of Arrangement) held by them an amount equal to $16.66 2/3 in cash plus 0.010030 ordinary shares, nominal value $0.0001 per share, of Jazz ("Jazz ordinary shares"). The transaction is more fully described in the Company's definitive proxy statement filed with the Securities and Exchange Commission on March 15, 2021.
(3) Pursuant to the Transaction Agreement, dated as of February 3, 2021 (the "Transaction Agreement"), by and among the Company, Jazz and Bidco, these share options vested (to the extent unvested) and were canceled in connection with the closing of the transactions contemplated by the Transaction Agreement in exchange for an all-cash payment equal to the value of the share options based on the value of the transaction consideration.
(4) Pursuant to the Transaction Agreement, one-third of these share options vested and were canceled in connection with the closing of the transactions contemplated by the Transaction Agreement in exchange for an all-cash payment equal to the value of the share options based on the value of the transaction consideration, and the remaining two-thirds were converted into an option to acquire Jazz ordinary shares (with any performance goals deemed fully satisfied), half of which will vest on March 2, 2022 and half of which will vest on March 2, 2023.
Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
GUY GEOFFREY W DR
SOVEREIGN HOUSE, VISION PARK, HISTON
CAMBRIDGE, X0 CB24 9BZ		X
Executive Chairman
Signatures
/s/ Dr. Geoffrey W. Guy5/7/2021
**Signature of Reporting PersonDate
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