RNS Number:1405S
Skyepharma PLC
17 November 2003

For Immediate Release                                           17 November 2003

                         SkyePharma PLC ("the Company")

                    Notification of Major Interest in Shares

In accordance with Part VI of the Companies Act 1985 (as amended) the Company
was informed today that on 14 November 2003 Standard Life Investments, on behalf
of the Standard Life Group, purchased 2,000,000 SkyePharma plc Ordinary Shares,
thus increasing their holding to 26,230,736 Ordinary Shares, representing 4.25%
of the issued share capital of the Company. These Ordinary Shares are registered
in the name of Stanlife Nominees Limited.


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